A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.
Prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.
Removal of bone marrow and evaluation of its histologic picture.
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Simple protein, one of the prolamines, derived from the gluten of wheat, rye, etc. May be separated into 4 discrete electrophoretic fractions. It is the toxic factor associated with CELIAC DISEASE.

Anti-tissue transglutaminase, anti-endomysium and anti-R1-reticulin autoantibodies-the antibody trinity of coeliac disease. (1/111)

Anti-tissue transglutaminase has been recently described as the predominant autoantigen in coeliac disease. We purified serum anti-tissue transglutaminase antibodies from three patients with coeliac disease by column chromatography and eluted tissue section-bound R1-anti-reticulin antibodies from sections of rat tissue for two of these. Lastly, we generated seven mouse MoAbs to guinea pig tissue transglutaminase. Each preparation was examined for anti-tissue transglutaminase, anti-endomysium, anti-R1 reticulin and anti-gliadin antibodies. Column-purified patient antibodies and 2/7 mouse MoAbs gave characteristic anti-endomysium/anti-R1 reticulin reactivity on rat, monkey and human tissue. All positive sera gave indistinguishable patterns of immunofluorescence on rat liver, kidney and stomach, monkey oesophagus, and human umbilical cord. Anti-R1-reticulin eluted from sections showed anti-tissue transglutaminase reactivity in 2/2 cases, but 0/2 showed anti-gliadin reactivity. In both, tissue section-eluted anti-R1 reticulin gave endomysial staining on monkey oesophagus. None of the mouse monoclonals, or any of the purified patient's anti-tissue transglutaminase or anti-R1-reticulin antibody showed any reactivity with gliadin. These data confirm tissue transglutaminase as the predominant autoantigen in coeliac disease and suggest that both anti-endomysium and anti-R1 reticulin reactivities seen in coeliac disease arise due to an immune response to tissue transglutaminase. Rigorous immunoabsorption was sufficient to abrogate reactivity in the tissue transglutaminase ELISA, but failed to completely absorb anti-endomysium and anti-reticulin activity. The possibility remains that some of the anti-endomysium and anti-reticulin activity was directed against antigens other than tissue transglutaminase.  (+info)

Changing jejunal gamma delta T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease. (2/111)

The function of jejunal intraepithelial gamma delta+ T cells is obscure, but they are commonly implicated as playing a role in inflammatory and autoimmune conditions. In coeliac disease (CoD), there are controversial reports as to gluten dependency of these cells. We have now studied the small bowel mucosal intraepithelial T cell densities, and the ratios of gamma delta+ to CD3+ T cells and gamma delta+ to alpha beta+ T cells during early disease development and on a gluten-free diet. Nine children initially excluded for CoD were followed up and rebiopsy after 0.8-4.5 years showed mucosal deterioration. Further, 21 biopsy specimens from newly diagnosed CoD patients were studied, together with 20 specimens taken from children on a gluten-free diet. During CoD development the density of gamma delta+ and alpha beta+ T cells as well as the ratios of gamma delta+ to CD3+ T cells and gamma delta+ to alpha beta+ T cells increased. In the latent stage of CoD when the small bowel mucosal architecture was still normal, two children had clearly normal densities of gamma delta+ (< 2.5 cells/100 epithelial cells) and alpha beta+ (< 25.0 cells/100 epithelial cells) T cells, and low ratios as well. In patients with newly diagnosed CoD the densities decreased significantly on a long-term gluten-free diet. We conclude that the density of intraepithelial gamma delta+ T cells as well as alphabeta+ T cells in CoD is gluten-dependent. CoD can develop in a child ingesting normal amounts of gluten and having normal jejunal mucosal morphology on biopsy and a normal density of gamma delta+ T cells.  (+info)

IgA anti-tissue transglutaminase as a diagnostic marker of gluten sensitive enteropathy. (3/111)

AIMS: To compare and contrast the sensitivity, specificity, and positive predictive values of IgA antibodies to guinea pig tissue transglutaminase (ELISA), endomysium, and reticulin (immunofluorescence), and gliadin (ELISA), and IgG antibodies to gliadin and tissue transglutaminase. METHODS: Sera from 27 newly diagnosed patients with coeliac disease, 65 biopsied gastrointestinal disease controls, and 50 consecutive blood donors were tested. All cases were adults. RESULTS: IgA anti-tissue transglutaminase showed a sensitivity of 85% (23/27 coeliac disease cases seropositive), specificity 97% (2/65 controls and one blood donor showing low titre positivity), and a positive predictive value of 92%. High titre anti-tissue transglutaminase was only seen in coeliac disease. Disease controls with mucosal damage unrelated to gluten enteropathy were IgA anti-tissue transglutaminase negative. Sensitivity, specificity, and positive predictive values for IgA anti-endomysial antibody (monkey oesophagus) were 100%, 100%, and 100%, respectively, and for IgA anti-gliadin, 93%, 95%, and 89%, respectively. CONCLUSIONS: Tissue transglutaminase is a major autoantigen in coeliac disease. IgA (but not IgG) anti-tissue transglutaminase, especially when in high titre, is closely associated with coeliac disease, but low titres may not be disease specific. In this small pilot study, the established IgA anti-endomysial assay was the superior test.  (+info)

Histological alterations in bone marrow in patients with late engraftment after autologous bone marrow transplantation. (4/111)

Bone marrow histology after bone marrow transplantation has rarely been studied. Here, we reviewed the pre- and post-transplant bone marrow biopsies (BMB) of 40 acute myelogenous leukemia (AML) patients autografted in our center, 28 with normal and 12 with delayed peripheral recovery. The two groups were comparable in terms of previous therapy, disease phase and the number of infused cells, and received the same conditioning regimen. In the former group, reduced bone marrow cellularity and mild reticulin abnormalities were usual histological findings; in the latter, five patients had the same pattern, but the other seven had an almost undetectable hematopoietic parenchyma and severe reticulin derangement. One of these seven patients died of reactivated hepatitis B virus infection; the others eventually achieved peripheral recovery, with none of them experiencing a relapse. Autografted AML patients are excellent subjects for histological investigations. They account for the majority of delayed engraftments, the contribution of extramedullary components to the timing of engraftment is minimal, and leukemia relapse cannot be ruled out. These results suggest that BMB is a useful investigation in the work-up of late engraftment. A high degree of reticulin derangement with an almost undetectable hematopoietic parenchyma appear to be the morphological hallmarks of late engraftment.  (+info)

Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer. (5/111)

To define the role of asymptomatic autoimmune thyroiditis in the cause of breast cancer, the presence of circulating thyroid autoantibodies was studied in two populations, one with a high risk of breast cancer (British women) and one with a low risk (Japanese women). Ostensibly healthy women and patients with breast cancer from both countries were studied. There was no difference in the incidence of thyroid autoantibodies between women with breast cancer and healthy women in either race. The incidence of thyroid autoantibodies in healthy British women, however, was two to three times that in healthy Japanese women. The incidence of reticulin antibodies, was considerably higher in both groups of Japanese women. No remarkable differences in the incidence of antinuclear, smooth-muscle, antimitochondrial, gastric parietal cell, or liver-kidney microsomal antibodies were found between women with breast cancer and healthy women or between the two races. Only the incidence of antinuclear antibodies was marginally higher in Japanese patients with advanced cancer. These results indicate that asymptomatic autoimmune thyroid disease is more prevalent among British than among Japanese women, but they fail to provide direct evidence that autoimmune thyroid disease is associated with breast cancer. Prospective studies of women with autoimmune thyroiditis and studies of young women from low-risk and high-risk populations are needed.  (+info)

Relevance and dynamics of myelofibrosis regarding hematopoietic reconstitution after allogeneic bone marrow transplantation in chronic myelogenous leukemia--a single center experience on 160 patients. (6/111)

A retrospective single center study was performed on 516 trephine biopsies derived from 160 patients with stable phase Ph+-CML and allogeneic BMT. Following morphometric quantification of reticulin-collagen fibers we tried to elucidate (1) the dynamics of bone marrow fibrosis in the post-transplant period; and (2) the influence of manifest myelofibrosis on relevant engraftment parameters. An evaluation of fiber density at standardized endpoints after BMT was carried out on a selected cohort of 124 patients (399 biopsy specimens). A manifest myelofibrosis (more than a three-fold increase compared to the normal fiber content) before BMT was found in 26% of our patients. Concentrating on bone marrow areas with reconstituting hematopoiesis, several findings emerged. Pretransplant myelofibrosis was associated with an initial regression following BMT, but insidiously recurred in the areas of regenerating hematopoiesis or developed in a few patients without increased pregraft fibers during the post-transplant period (mean observation time more than 4 months). Severe acute GVHD (grades III and IV) was significantly correlated with a greater amount of reticulin fibers in the early post-transplant period (9 to 30 days after BMT). Regarding engraftment parameters, a significant delay was detectable in the time to achieve transfusion independence for the patients with manifest myelofibrosis compared to those without pre-transplant fiber increase.  (+info)

Smooth muscle antibody in patients with warts. (7/111)

Sera from fifty-four patients with warts were tested for the presence of commonly found autoantibodies. Smooth muscle antibody (SMA) was detected at a significantly higher level than in a control group of healthy blood donors matched for age and sex, and was in the IgM class. The SMA-positive sera gave a microfilamentous staining pattern also in the IgM class, on fixed HEp2 tissue culture cells. Absorption of positive sera with smooth muscle removed both SMA staining and the anti-cellular staining.  (+info)

Reticulin antibodies in patients with coeliac disease and their relatives. (8/111)

The sera of 69 index coeliac patients, 121 of their first-degree relatives, and 104 controls were screened for the presence of reticulin antibodies. Among the untreated coeliac patients 75% of adults and 93% of children had reticulin antibody in their serum. Reticulin antibody was not present in any adequately treated coeliac patient. Of the first-degree relatives, 21 were reticulin antibody positive; 17 of these were biopsied and 12 were shown to have coeliac disease. Sixty-five of the coeliac relatives who did not have reticulin antibodies in their sera were biopsied and two had coeliac disease. Of the 68 relatives and 63 controls with normal biopsies, five of the relatives and four of the controls were reticulin antibody positive.  (+info)

Reticulin is a type of protein fiber that forms part of the extracellular matrix in various connective tissues in the body. It is composed of collagenous and non-collagenous proteins, and it has a reticular or network-like structure when viewed under a microscope. In histology (the study of the microscopic structure of tissues), reticulin fibers are often stained to help identify certain types of cells or structures.

In particular, reticulin fibers are often found in close association with certain types of cells, such as hematopoietic stem cells and neurons. They provide structural support and help regulate the function of these cells. In addition, reticulin fibers play a role in the immune response, wound healing, and tissue repair.

Abnormal accumulations of reticulin fibers can be seen in various disease states, such as fibrosis (excessive scarring) and certain types of cancer. For example, increased reticulin fibers are often found in the liver in patients with cirrhosis, a condition characterized by extensive scarring and damage to the liver. Similarly, abnormal reticulin fiber deposition is seen in some forms of lymphoma, a type of cancer that affects the lymphatic system.

Primary myelofibrosis (PMF) is a rare, chronic bone marrow disorder characterized by the replacement of normal bone marrow tissue with fibrous scar tissue, leading to impaired production of blood cells. This results in cytopenias (anemia, leukopenia, thrombocytopenia), which can cause fatigue, infection susceptibility, and bleeding tendencies. Additionally, PMF is often accompanied by the proliferation of abnormal megakaryocytes (large, atypical bone marrow cells that produce platelets) and extramedullary hematopoiesis (blood cell formation outside the bone marrow, typically in the spleen and liver).

PMF is a type of myeloproliferative neoplasm (MPN), which is a group of clonal stem cell disorders characterized by excessive proliferation of one or more types of blood cells. PMF can present with various symptoms such as fatigue, weight loss, night sweats, abdominal discomfort due to splenomegaly (enlarged spleen), and bone pain. In some cases, PMF may progress to acute myeloid leukemia (AML).

The exact cause of PMF remains unclear; however, genetic mutations are known to play a significant role in its development. The Janus kinase 2 (JAK2), calreticulin (CALR), and MPL genes have been identified as commonly mutated in PMF patients. These genetic alterations contribute to the dysregulated production of blood cells and the activation of signaling pathways that promote fibrosis.

Diagnosis of PMF typically involves a combination of clinical evaluation, complete blood count (CBC), bone marrow aspiration and biopsy, cytogenetic analysis, and molecular testing to identify genetic mutations. Treatment options depend on the individual patient's symptoms, risk stratification, and disease progression. They may include observation, supportive care, medications to manage symptoms and control the disease (such as JAK inhibitors), and stem cell transplantation for eligible patients.

Celiac disease is a genetic autoimmune disorder in which the consumption of gluten, a protein found in wheat, barley, and rye, leads to damage in the small intestine. In people with celiac disease, their immune system reacts to gluten by attacking the lining of the small intestine, leading to inflammation and destruction of the villi - finger-like projections that help absorb nutrients from food.

This damage can result in various symptoms such as diarrhea, bloating, fatigue, anemia, and malnutrition. Over time, if left untreated, celiac disease can lead to serious health complications, including osteoporosis, infertility, neurological disorders, and even certain types of cancer.

The only treatment for celiac disease is a strict gluten-free diet, which involves avoiding all foods, beverages, and products that contain gluten. With proper management, individuals with celiac disease can lead healthy lives and prevent further intestinal damage and related health complications.

Dermatitis herpetiformis (DH) is a chronic, autoimmune blistering skin disorder that is characterized by the presence of symmetrical, pruritic (itchy), papulo-vesicular (papules and small fluid-filled blisters) eruptions on the extensor surfaces of the body, such as the elbows, knees, buttocks, and shoulders. It is often associated with gluten sensitivity or celiac disease, a condition that causes an abnormal immune response to gluten, a protein found in wheat, barley, and rye.

The exact cause of DH is not fully understood, but it is believed to result from the interaction between genetic, environmental, and immunological factors. The disorder is characterized by the presence of IgA antibodies in the skin, which trigger an immune response that leads to the formation of the characteristic rash.

DH is typically treated with a gluten-free diet, which can help to control the symptoms and prevent complications such as malabsorption and nutritional deficiencies. Medications such as dapsone may also be used to control the itching and blistering associated with the disorder. In some cases, topical corticosteroids or other anti-inflammatory medications may be prescribed to help manage symptoms.

It is important to note that DH is a chronic condition that requires ongoing management and monitoring. People with DH should work closely with their healthcare provider to develop an appropriate treatment plan and monitor their progress over time.

"Gluten" is not strictly defined as a medical term, but it refers to a group of proteins found in certain grains, including wheat, barley, and rye. Gluten gives these grains their elasticity and helps them maintain their shape, making it possible to bake breads and other baked goods.

From a medical perspective, gluten is significant because some people have adverse reactions to it. The two main conditions related to gluten are celiac disease and non-celiac gluten sensitivity. In both cases, consuming gluten can lead to various symptoms such as gastrointestinal distress, fatigue, and skin rashes.

Celiac disease is an autoimmune disorder where the ingestion of gluten causes damage to the small intestine lining, impairing nutrient absorption. On the other hand, non-celiac gluten sensitivity does not involve an immune response or intestinal damage but can still cause uncomfortable symptoms in some individuals.

It is essential to understand that a gluten-free diet should be medically recommended and supervised by healthcare professionals for those diagnosed with celiac disease or non-celiac gluten sensitivity, as it may lead to nutritional deficiencies if not properly managed.

A bone marrow examination is a medical procedure in which a sample of bone marrow, the spongy tissue inside bones where blood cells are produced, is removed and examined. This test is used to diagnose or monitor various conditions affecting blood cell production, such as infections, leukemia, anemia, and other disorders of the bone marrow.

The sample is typically taken from the hipbone (iliac crest) or breastbone (sternum) using a special needle. The procedure may be done under local anesthesia or with sedation to minimize discomfort. Once the sample is obtained, it is examined under a microscope for the presence of abnormal cells, changes in cell size and shape, and other characteristics that can help diagnose specific conditions. Various stains, cultures, and other tests may also be performed on the sample to provide additional information.

Bone marrow examination is an important diagnostic tool in hematology and oncology, as it allows for a detailed assessment of blood cell production and can help guide treatment decisions for patients with various blood disorders.

Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN), a type of blood cancer characterized by the overproduction of platelets (thrombocytosis) in the bone marrow. In ET, there is an excessive proliferation of megakaryocytes, the precursor cells that produce platelets. This leads to increased platelet counts in the peripheral blood, which can increase the risk of blood clots (thrombosis) and bleeding episodes (hemorrhage).

The term "essential" is used to indicate that the cause of this condition is not known or idiopathic. ET is primarily a disease of older adults, but it can also occur in younger individuals. The diagnosis of essential thrombocythemia requires careful evaluation and exclusion of secondary causes of thrombocytosis, such as reactive conditions, inflammation, or other myeloproliferative neoplasms.

The clinical presentation of ET can vary widely among patients. Some individuals may be asymptomatic and discovered only during routine blood tests, while others may experience symptoms related to thrombosis or bleeding. Common symptoms include headaches, visual disturbances, dizziness, weakness, numbness, or tingling in the extremities, if there are complications due to blood clots in the brain or other parts of the body. Excessive bruising, nosebleeds, or blood in the stool can indicate bleeding complications.

Treatment for essential thrombocythemia is aimed at reducing the risk of thrombosis and managing symptoms. Hydroxyurea is a commonly used medication to lower platelet counts, while aspirin may be prescribed to decrease the risk of blood clots. In some cases, interferon-alpha or ruxolitinib might be considered as treatment options. Regular follow-up with a hematologist and monitoring of blood counts are essential for managing this condition and detecting potential complications early.

Bone marrow is the spongy tissue found inside certain bones in the body, such as the hips, thighs, and vertebrae. It is responsible for producing blood-forming cells, including red blood cells, white blood cells, and platelets. There are two types of bone marrow: red marrow, which is involved in blood cell production, and yellow marrow, which contains fatty tissue.

Red bone marrow contains hematopoietic stem cells, which can differentiate into various types of blood cells. These stem cells continuously divide and mature to produce new blood cells that are released into the circulation. Red blood cells carry oxygen throughout the body, white blood cells help fight infections, and platelets play a crucial role in blood clotting.

Bone marrow also serves as a site for immune cell development and maturation. It contains various types of immune cells, such as lymphocytes, macrophages, and dendritic cells, which help protect the body against infections and diseases.

Abnormalities in bone marrow function can lead to several medical conditions, including anemia, leukopenia, thrombocytopenia, and various types of cancer, such as leukemia and multiple myeloma. Bone marrow aspiration and biopsy are common diagnostic procedures used to evaluate bone marrow health and function.

Gliadin is a protein fraction found in gluten, a complex protein that's present in certain grains such as wheat, barley, and rye. It is particularly known for its role in celiac disease, a disorder where the ingestion of gluten leads to an immune response that damages the lining of the small intestine.

Gliadin, along with another protein fraction called glutenin, makes up gluten. Gliadin is responsible for the elastic properties of dough. When water is added to flour and mixed, these proteins form a sticky network that gives dough its characteristic texture and allows it to rise and maintain its shape during baking.

In individuals with celiac disease, the immune system recognizes gliadin as a foreign invader and mounts an immune response against it. This response leads to inflammation and damage in the small intestine, preventing the absorption of nutrients from food. Over time, this can lead to various health complications if not properly managed through a gluten-free diet.

In pathology, the reticulin stain is a popular staining method in histology. It is used to visualize reticular fiber and used ...
The term reticulin was coined in 1892 by M. Siegfried. Today, the term reticulin or reticular fiber is restricted to referring ... Reticulin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) MedEd at Loyola Histo/practical/stains/hp2- ... However, during the pre-molecular era, there was confusion in the use of the term reticulin, which was used to describe two ... Reticular fibers crosslink to form a fine meshwork (reticulin). This network acts as a supporting mesh in soft tissues such as ...
Also, reticulin fibrosis is rare. There is a reported association between CNL and multiple myeloma, so the bone marrow biopsy ...
"There is dense intercellular reticulin staining. Tumor cells can be fibroblastic, myxoid, or pericytic. These tumors, in ...
Reticulin (+)-Laudanosine Papaverine has vasodilator and muscle relaxant properties. Laudanosine acts as a tetanic poison. The ... The benzylisoquinoline from this reaction may have different substituents, reticulin is an important intermediate. Entry on ...
The use of anagrelide was associated with a rapid increase in the degree of reticulin deposition (the mechanism by which ... Thus, patients on anagrelide may need to be monitored on a periodic basis for marrow reticulin scores, especially if anemia ... June 2009). "Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy". J. Clin ...
Hall, D.A.; Saxl, Hedwig (1961). "Studies of Human and Tunicate Cellulose and of their Relation to Reticulin". Proceedings of ...
The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is ... Reticulin stain Inflammatory hepatocellular adenoma Some authors feel that all hepatocellular adenoma should be resected, ... The hepatocytes are on a regular reticulin scaffold and less or equal to three cell thick. ...
Hall, D. A.; Saxl, H. (1961). "Studies of Human and Tunicate Cellulose and of their Relation to Reticulin". Proceedings of the ...
"Polarized light microscopy in the study of the molecular structure of collagen and reticulin". Histochemistry. 85 (1): 41-49. ...
Thin reticular fibers (reticulin) of reticular connective tissue form a supporting meshwork inside the node. The lymph node ...
... fibroblast secrete collagen and reticulin proteins that are collectively referred to as (fibrosis). These two pathological ...
Reticulin or collagen fibrosis grade 2 or 3 is a diagnostic criteria for primary myelofibrosis. Both pre-PMF and Essential ... The presence of Reticulin fibrosis in pre-PMF provides the clearest distinction between the two. Patients considered low risk ... Reticulin fibrosis which doesn't exceed grade 1. Grade 2 or 3 is a diagnostic criteria for primary myelofibrosis. Age-adjusted ...
With picric acid, in a van Gieson procedure, it can be used to stain collagen and reticulin. Western blot normalization "AMIDO ...
It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations. Symptoms and ... The giant-cell glioblastoma was originally termed "monstrocellular sarcoma", because of its stromal reticulin network, but the ...
Historically three other antibodies were measured: anti-reticulin (ARA), anti-gliadin (AGA) and anti-endomysial (EMA) ... Serology tests are based on indirect immunofluorescence (reticulin, gliadin and endomysium) or ELISA (gliadin or tissue ...
No evidence of myelofibrosis no collagen fibrosis and ≤ grade 2 reticulin fibrosis (using 0-4 scale) B6. No evidence of a ...
However, a bone marrow biopsy will show reticulin and/or collagen fibrosis with a grade 2 or 3. Anemia, splenomegaly, LDH above ... There should be no increase in reticulin fibers and the patient should not meet the criteria for other MPNs, in particular Pre- ... or MPL mutations and shows reticulin fibrosis no greater than grade 1. Anemia, splenomegaly, LDH above the upper limits and ...
Then, collagen and reticulin fibers are unstained by a reaction with phosphotungstic acid and stained in yellow by saffron. ...
... s are organised into plates separated by vascular channels (sinusoids), an arrangement supported by a reticulin ( ...
... reticulin). An in vitro study with native collagen demonstrated that fibronectin binds to type III collagen rather than other ...
... reticulin, tetrahydropapaveroline (THP), and tyramine (Kulkarni, 2001; Mantione et al., 2008; Zhu, 2008). Novak B, Hudlicky T, ...
Bone-marrow failure is caused by the accumulation of hairy cells and reticulin fibrosis in the bone marrow, as well as by the ...
... employ the use of a supravital dye such as new methylene blue to stain the red cells containing reticulin prior to counting. ...
Serology for anti-tTG antibodies has superseded older serological tests (anti-endomysium, anti-gliadin, and anti-reticulin) and ...
Pigmented fragments of metal within connective tissue Staining of reticulin fibers with silver salts A scattered arrangement of ...
These include: reticulin muscle protein collagen (a hard tissue protein), which survives even longer than the former tissue ...
These include type II collagen in the cartilaginous zones, type III collagen in the reticulin fibres of the vascular walls, ...
... collagen and reticulin) in them. Plate short ribs tend to be fattier than the other two types. Short ribs cut from the rib area ...
... physician and discoverer of reticulin Anamaria Nesteriuc (1993-), athlete Mihai Netea (1968-), physician and professor Victor ...
In pathology, the reticulin stain is a popular staining method in histology. It is used to visualize reticular fiber and used ...
... Jennifer MacDonald JMacDonald at mtsac.edu Thu Jul 21 14:51:41 CDT 2016 *Previous message (by thread ... Previous message (by thread): [Histonet] Reticulin Stain *Next message (by thread): [Histonet] Best semi-automated/automated ...
Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural ... "Reticulin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Reticulin" by people in this website by year, and whether " ... Below are the most recent publications written about "Reticulin" by people in Profiles. ...
Posts about reticulin written by Histology Reference Guide ... Tag: reticulin. Positive Control Slides (Amazing Prices). ...
Learn more about Reticulin on CHOMP. Find food with Reticulin. CHOMP helps you find foods that are compatible with your dietary ... Is Reticulin Vegan?. One of the structural elements (together with elastin and collagen) of skeletal muscle. ...
Grade 3 reticulin fibrosis with dense intersections and thick bundles as seen on reticulin stain. ... Grade 3 reticulin fibrosis with dense intersections and thick bundles as seen on reticulin stain. ...
Gomoris Reticulin Fiber. Reticulin fibers support the body and are common in the liver, spleen and kidneys. Characteristic ... Troubleshooting the Gomoris reticulin:. Silver solution should be made fresh with distilled water and clean glassware (acid ... Reticulin stains use silver and rely on the argyrophilic properties of the fibers. Argyrophilic cells can adsorb silver but ... reticulin patterns can help diagnose cirrhosis of the liver, early fibrosis in bone marrow, tumors including: hemangiosarcomas ...
2021 - 2023 Top 16 Pill for Adverse Reaction BONE MARROW RETICULIN FIBROSIS ...
In the reticulin stain, a complete reticular fiber appeared, and the thickness of the fiber was moderate and uniform. In 19 ... Rapid Reticulin Fiber Staining Method is Helpful for the Diagnosis of Pituitary Adenoma in Frozen Section. ENDOCR PATHOL 2015; ... The Ki-67 index of the patients ranged from 2% to 90%. The reticulin stain of 2 cases of normal adrenal cortex showed that the ... Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions. J ENDOCRINOL INVEST 2020;43;1571-1576. ...
The pleomorphic xanthoastrocytoma frequently exhibits pericellular reticulin. (Wilders reticulin, 40× original magnification.) ... The pleomorphic xanthoastrocytoma frequently exhibits pericellular reticulin. (Wilders reticulin, 40× original magnification.) ... 38] The reticulin corresponds to a basal lamina associated with each tumor cell. Lymphocytic and plasma cellular infiltrates ... The reticulin stain reveals a pericellular lamina around all of the cells in desmoplastic astrocytoma, not just the fibroblasts ...
The prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin fibrosis in essential thrombocythemia. ... Dive into the research topics of The prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin ... The prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin fibrosis in essential thrombocythemia. ... The prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin fibrosis in essential thrombocythemia. ...
Elastin-A dermal protein like collagen and reticulin. Applied topically, it is an excellent emollient that helps attract and ... Reticulin, Aloe Vera (For more information on these ingredients, see individual entries.). Eucalyptus-Antiseptic and ...
The adverse effects include hepatotoxicity, worsening of cataracts, and increased bone marrow reticulin fibers In the open- ...
Anti-Reticulin Antibodies.. 23. Apolipoprotein A1.. 24. Apolipoprotein B.. 25. Ascorbic Acid (ascorbate) Vitamin C. ...
Anti-Reticulin Antibodies.. 23. Apolipoprotein A1.. 24. Apolipoprotein B.. 25. Ascorbic Acid (ascorbate) Vitamin C. ...
Increase in reticulin fibers. Stains. Positive: Iron, CD68, PAS, TRAP, NSE. Negative: Sudan Black B, AFB ...
Categories: Reticulin Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 1 images ...
Reticulin staining (C-H) and Prolactin IHQ (I, J) of pituitary adenohypophysis from Rad51bWT/WT and Rad51bKI/KI. C, D Normal ... F Microadenoma from a Rad51bKI/KI showing a complete loss of reticulin staining pattern that is still persistent in the ... reticulin staining was performed automatically on the ArtisanTM Link Pro Special Staining System (Dako). Prolactin and ACTH ... neighbor misplaced adenohypophysis (magnified in F). G, H Macroadenoma from a Rad51bKI/KI showing total loss of reticulin ...
2B]). Interstitial stroma demonstrated presence of hyaline vessels and reticulin fibrils. Mitotic figures were lacking (, 1 ...
Reticulin = Black Collagen = Taupe Other = Counterstain method dependent. Gomori Stain. Demonstration of muscle cross- ...
Tumor within reticulin-rich areas is usually highly cellular and proliferatively active, whereas the reticulin-poor nodular ... Reticulin-free nodules of the desmoplastic variant are typically reactive for markers of neuronal lineage. Vimentin is usually ... Extensive stromal reticulin deposition may impart a firm consistency to the desmoplastic variant. Infiltration of the meninges ... variant that usually arises in a cerebellar hemisphere and is defined by the presence of a reticulin-rich stroma and reticulin- ...
MIB-1. What is your diagnosis?. Diagnosis: Primary diffuse large B cell lymphoma of the CNS. Discussion:. Primary diffuse large B-cell lymphoma of the central nervous system is a rare tumor that by definition, arises exclusively in the CNS with no obvious lymphoma elsewhere at diagnosis. It represents 5-10% of CNS neoplasms in patients ages 75+ (Hum Path 2003;34:1137). A majority of these neoplasms arise supratentorially within the white matter and in the periventricular area. They may be multifocal and may affect the leptomeninges, but primary leptomeningeal involvement is rare. At diagnosis, 20% have ocular involvement; and 80-90% of these patients develop contralateral tumors and intraparenchymal CNS lesions, with invasion of the subretinal pigment epithelial space and vitreous. Dissemination to extraneural sites such as bone marrow is extremely rare.. Radiologically, these tumors are generally solitary, homogeneously contrast enhancing and usually have no ring enhancement, in contrast to ...
Special stains such as reticulin can be used to highlight disruption of nested architecture. Immunohistochemical stains, ...
Rupture and loss of the perisinusoidal reticulin fibres lead to peliosis hepatis. In these cases liver biopsy might disclose ...
Systemic Mastocytosis : Bone Marrow - Reticulin. Mast Cell Leukemia. Mast Cell Leukemia. Systemic Mastocytosis : Spleen. ...
... including reticulin stain, glial fibrillary acidic protein, vimentin, pancytokeratin, neuron-specific nuclear protein, Olig2, ... neoplastic cells were individually surrounded by a reticulin-positive framework, which was immunoreactive with laminin. Viral ...
Reticulin stain shows moderate fibrosis within the lymphoid aggregate....so now Im seeing that B cells are less but more T ...
Marrow reticulin or collagen fibrosis. Childhood MDS with low blasts, hypocellular. , 5% in BM and , 2% in PB ...
Increased reticulin and collagen deposition in the bone marrow is the hallmark of MF. Reticulin and collagen are connective ... Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy. J Clin Oncol. 2009; ... Increased reticulin BMF has been reported in approximately 20% of patients with essential thrombocythemia and can also be seen ... However, BMF and reticulin deposition in the spleen occurred only in mice reconstituted with wild-type cells. Additionally, ...
  • In pathology, the reticulin stain is a popular staining method in histology. (wikipedia.org)
  • Grade 3 reticulin fibrosis with dense intersections and thick bundles as seen on reticulin stain. (hematology.org)
  • To investigate the diagnostic significance of reticulin stain in biopsy of adrenocortical carcinoma. (diagnosticpathology.eu)
  • 21 cases of adrenal mass biopsy specimens collected at Sun Yat-sen University Cancer Center from November 2008 to July 2021 which included 19 cases of adrenal cortical carcinoma (ACC) and 2 cases of normal adrenal cortical were evaluated for their histologic,immunohistochemical(IHC)and reticulin stain features, and relevant literature was reviewed. (diagnosticpathology.eu)
  • The reticulin stain of 2 cases of normal adrenal cortex showed that the reticular fibers were arranged regularly and completely wrapped the adrenal cortex cell. (diagnosticpathology.eu)
  • In the reticulin stain, a complete reticular fiber appeared, and the thickness of the fiber was moderate and uniform. (diagnosticpathology.eu)
  • Reticulin stain was an effective method for accurate diagnosis of adrenal cortical carcinoma. (diagnosticpathology.eu)
  • Reticulin stain shows moderate fibrosis within the lymphoid aggregate. (cancer.org)
  • Thin sections are cut and are stained, as a minimum, with haematoxylin and eosin and with a reticulin stain. (bmj.com)
  • Modest increases in reticulin fibers can be difficult to appreciate but can be confirmed with a silver impregnation technique, such as Gomori stain. (nih.gov)
  • Reticulin stain was done to confirm the HA and to see whether it has progressed up to the hepatocellular carcinoma (HCC). (who.int)
  • Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
  • Bone marrow fibrosis (BMF) is characterized by the increased deposition of reticulin fibers and in some cases collagen fibers. (haematologica.org)
  • Bone marrow fibrosis is a lesion characterized by an increase of reticulin fibers or reticulin and collagen fibers, and/or proliferating fibroblasts. (nih.gov)
  • In addition, reticulin fibrosis is more likely to reverse than is collagen fibrosis after removal or successful treatment of the causative disorder. (nih.gov)
  • The clinical course of individuals with MF is characterized by constitutional symptoms (fevers, night sweats, and weight loss), bone marrow myeloproliferation and reticulin/collagen fibrosis, worsening cytopenias, thrombosis, and progressive symptomatic splenomegaly. (cancernetwork.com)
  • 7 Pathologically, MF is characterized by thickening and distortion of bony trabeculae, deposition of reticulin and collagen fibers, and megakaryocytic hyperplasia with atypical features. (haematologica.org)
  • In humans, increased reticulin fibers are associated with many benign and malignant conditions, while increased collagen is prominent in late stages of myeloproliferative diseases or following metastasis to the bone marrow. (nih.gov)
  • Special stains such as reticulin can be used to highlight disruption of nested architecture. (cap.org)
  • The amount of reticulin staining in the bone marrow often has no correlation with disease severity, while increases in collagen staining are associated with more severe disease and a poorer prognosis. (nih.gov)
  • Results: There was non significant increase in the reticulin level in bone marrow of any of the patients although platelet count was very highly significant (p-value 0.000) increased as regard day to day follow up after Romiplostim injection with maximum peak from day 15 till day 33 in most of the patients. (omicsonline.org)
  • Reticulin and CD34 staining outlined the dense reticular capillary network of the tumor, but the typical dense pericellular network found in schwannoma was not present. (surgicalneurologyint.com)
  • Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. (wakehealth.edu)
  • Interstitial stroma demonstrated presence of hyaline vessels and reticulin fibrils. (thieme-connect.com)
  • Yasir S , Chen ZE, Said S, Wu TT, Torbenson M. Biopsies of hepatocellular carcinoma with no reticulin loss: an important diagnostic pitfall. (mayoclinic.org)
  • Rupture and loss of the perisinusoidal reticulin fibres lead to peliosis hepatis. (springer.com)
  • Endomysial antibodies of the IgA subclass present in the serum bind to the reticulin component of the endomysium of the smooth muscle in monkey esophagus tissue and can be detected by indirect immunofluorescence. (cdc.gov)
  • A preliminary diagnose can be made by serology (Gliadin-, endomysium and reticulin-antibodies) but to get a firm diagnose a small bowel biopsy is needed. (gastrolab.net)
  • Reticulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions. (diagnosticpathology.eu)
  • DEN control group showed well-preserved reticulin framework of normal liver, which confirms that HA , has not yet progressed up to HCC. (who.int)
  • IgG class anti-gliadin and anti-reticulin antibodies were positive but IgA class of these antibodies were negative. (pediatriconcall.com)
  • The reticulin algorithm for adrenocortical tumor diagnosis: a multicentric validation study on 245 unpublished cases. (diagnosticpathology.eu)
  • This graph shows the total number of publications written about "Reticulin" by people in this website by year, and whether "Reticulin" was a major or minor topic of these publications. (wakehealth.edu)
  • Rapid Reticulin Fiber Staining Method is Helpful for the Diagnosis of Pituitary Adenoma in Frozen Section. (diagnosticpathology.eu)
  • Une anémie a été diagnostiquée chez 75 patients (37,5 %) en tout : 45 avaient une anémie hypochrome microcytaire, 18 une anémie normochrome normocytaire et 12 une anémie hyperchrome macrocytaire. (who.int)
  • Sur les 75 patients, 41 (54,7 %) avaient une carence en fer, 14 (18,7 %) avaient une carence en folates et 14 (18,7 %) avaient une thalassémie mineure. (who.int)
  • A comparison is made of the ability of these minerals to promote reticulin deposition in vivo following instillation into rats with the ability of each mineral to alter cell mat hydroxyproline levels in fibroblast cultures. (nih.gov)
  • 13. Bone marrow hyaluronan and reticulin in patients with malignant disorders. (nih.gov)
  • Endomysial antibodies of the IgA subclass present in the serum bind to the reticulin component of the endomysium of the smooth muscle in monkey esophagus tissue and can be detected by indirect immunofluorescence. (cdc.gov)
  • The amount of reticulin staining in the bone marrow often has no correlation with disease severity, while increases in collagen staining are associated with more severe disease and a poorer prognosis. (nih.gov)