"Research Support, U.S. Gov't, Non-P.H.S." is not a medical condition or diagnosis. Instead, it refers to a source of research funding from the United States Government, outside of the Public Health Service (PHS).

The National Library of Medicine's (NLM) controlled vocabulary thesaurus, MeSH (Medical Subject Headings), uses this term as a way to categorize and index biomedical literature. Specifically, it is used to describe research that has been supported by funds from the U.S. Government, but not through the PHS, which is a division of the U.S. Department of Health and Human Services (HHS).

Therefore, if you encounter this term in a medical paper or journal article, it indicates that the research was funded by the U.S. Government, but not specifically by the Public Health Service.

"Research Support, U.S. Gov't, P.H.S." is a grant category used in scientific research publications to denote funding support received from the U.S. Department of Health and Human Services (HHS), specifically from its agency, the Public Health Service (PHS). This type of funding indicates that the research was supported by grants or awards issued by the PHS, which may include organizations such as the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), or other HHS agencies. The support could be in the form of financial assistance, resources, or facilities provided to conduct the research project. It is essential to disclose this information to promote transparency and manage potential conflicts of interest in scientific research.

"Research Support, Non-U.S. Government" is a standard designation used in biomedical research funding and publication metadata to describe financial or material support for research that comes from sources outside of the United States government. This can include funding or resources provided by non-governmental organizations (NGOs), universities, hospitals, foundations, corporations, or other entities based in another country.

It's important to note that this designation is used to help readers understand any potential conflicts of interest or biases that may be associated with the funding source, and to ensure transparency in research reporting.

"Research Support, U.S. Government" is not a medical condition or term. It is a classification code used in research funding and publication metrics. This code is used to categorize research that has received financial support from the U.S. government, typically through agencies such as the National Institutes of Health (NIH), National Science Foundation (NSF), or Department of Defense (DOD).

This classification helps identify the source of funding for a research project and acknowledges the role of the U.S. government in supporting scientific investigation. It does not have any direct medical relevance but is important for transparency and accountability in research funding.

"Research Support, American Recovery and Reinvestment Act" is not a medical term or concept in and of itself. However, the American Recovery and Reinvestment Act (ARRA) of 2

"Research Support, N.I.H., Extramural" is not a medical condition or diagnosis. Instead, it refers to a type of funding support provided by the National Institutes of Health (NIH) in the United States.

The NIH is the primary agency of the U.S. government responsible for biomedical and public health research. It supports both intramural and extramural research. Intramural research refers to projects conducted within the NIH's own laboratories and research facilities, while extramural research refers to projects supported by NIH funding but carried out at universities, medical schools, hospitals, and other research institutions outside of the NIH.

"Research Support, N.I.H., Extramural" specifically refers to financial support provided by the NIH to extramural researchers through various grant mechanisms, such as research project grants (R01), small research grants (R03), and career development awards (K-awards). These grants enable investigators to conduct independent research projects that address important biomedical and public health questions, with the goal of advancing knowledge and improving human health.

"Research Support, N.I.H., Intramural" is a grant category used by the U.S. National Institutes of Health (NIH) to describe funding that supports research projects conducted by investigators within the NIH's own intramural research program. The NIH intramural research program is the internal research program carried out by the NIH's own scientists and staff at its campuses across the country. This funding mechanism supports a wide range of biomedical research projects conducted by NIH investigators, and it does not involve the awarding of funds to external researchers or institutions.

"Research Support as Topic" is not a specific medical term or diagnosis. However, in the context of medical literature and research, "research support" refers to the resources, funding, and infrastructure that enable and facilitate the conduct of scientific research. This can include financial support from various sources such as government agencies, private organizations, or institutions; access to laboratory facilities, equipment, and databases; and technical assistance in study design, data collection and analysis, and manuscript preparation.

When "research support" is designated as a topic in medical literature, it typically refers to articles that discuss the various aspects of research funding, ethics, and management, including best practices for grant writing, financial conflict of interest disclosures, and responsible conduct of research. It may also include studies that examine the impact of research support on the quality, quantity, and outcomes of scientific research.

Isosorbide dinitrate is a medication that belongs to a class of drugs called nitrates. It is primarily used in the prevention and treatment of angina pectoris, which is chest pain caused by reduced blood flow to the heart muscle.

The medical definition of Isosorbide dinitrate is:

A soluble nitrate ester used in the prevention and treatment of anginal attacks. It acts by dilating coronary and peripheral arteries and veins, thereby reducing cardiac workload and increasing oxygen delivery to the heart muscle. Its therapeutic effects are attributed to its conversion to nitric oxide, a potent vasodilator, in the body. Isosorbide dinitrate is available in various forms, including tablets, capsules, and oral solutions, and is typically taken 2-3 times daily for optimal effect.

Hydralazine is an antihypertensive medication, which means it is used to treat high blood pressure. It works by relaxing and widening the blood vessels, making it easier for the heart to pump blood through the body. This can help reduce the workload on the heart and lower blood pressure. Hydralazine is available in oral tablet form and is typically prescribed to be taken several times a day.

Hydralazine belongs to a class of medications called vasodilators, which work by relaxing the muscle in the walls of the blood vessels, causing them to widen. This increases the amount of blood that can flow through the blood vessels and reduces the pressure within them. Hydralazine is often used in combination with other medications to treat high blood pressure.

It's important to note that hydralazine should be used under the close supervision of a healthcare provider, as it can cause side effects such as headache, dizziness, and rapid heartbeat. It may also interact with certain other medications, so it is important to inform your doctor of all medications you are taking before starting hydralazine.

Research, in the context of medicine, is a systematic and rigorous process of collecting, analyzing, and interpreting information in order to increase our understanding, develop new knowledge, or evaluate current practices and interventions. It can involve various methodologies such as observational studies, experiments, surveys, or literature reviews. The goal of medical research is to advance health care by identifying new treatments, improving diagnostic techniques, and developing prevention strategies. Medical research is typically conducted by teams of researchers including clinicians, scientists, and other healthcare professionals. It is subject to ethical guidelines and regulations to ensure that it is conducted responsibly and with the best interests of patients in mind.

I'm sorry for any confusion, but "United States" is a geopolitical entity, specifically the name of the country consisting of 50 states, and it is not a medical term or concept. Therefore, I can't provide a medical definition for it. If you have any questions related to health, medicine, or biology, I would be happy to try to help answer those!

A research design in medical or healthcare research is a systematic plan that guides the execution and reporting of research to address a specific research question or objective. It outlines the overall strategy for collecting, analyzing, and interpreting data to draw valid conclusions. The design includes details about the type of study (e.g., experimental, observational), sampling methods, data collection techniques, data analysis approaches, and any potential sources of bias or confounding that need to be controlled for. A well-defined research design helps ensure that the results are reliable, generalizable, and relevant to the research question, ultimately contributing to evidence-based practice in medicine and healthcare.

Research ethics refers to the principles and guidelines that govern the conduct of research involving human participants or animals. The overarching goal of research ethics is to ensure that research is conducted in a way that respects the autonomy, dignity, and well-being of all those involved. Research ethics are designed to prevent harm, promote fairness, and maintain trust between researchers and study participants.

Some key principles of research ethics include:

1. Respect for Persons: This means treating all individuals with respect and dignity, and recognizing their autonomy and right to make informed decisions about participating in research.
2. Beneficence: Researchers have a duty to maximize the benefits of research while minimizing potential harms.
3. Justice: Research should be conducted fairly, without discrimination or bias, and should benefit all those who are affected by it.
4. Confidentiality: Researchers must protect the privacy and confidentiality of study participants, including their personal information and data.
5. Informed Consent: Participants must give their voluntary and informed consent to participate in research, after being fully informed about the nature of the study, its risks and benefits, and their rights as a participant.

Research ethics are typically overseen by institutional review boards (IRBs) or research ethics committees (RECs), which review research proposals and monitor ongoing studies to ensure that they comply with ethical guidelines. Researchers who violate these guidelines may face sanctions, including loss of funding, suspension or revocation of their research privileges, or legal action.

Research personnel, in the context of medical and scientific research, refers to individuals who are involved in the design, conduct, or reporting of research studies. This can include, but is not limited to, principal investigators, co-investigators, research assistants, research coordinators, data managers, biostatisticians, and laboratory technicians. These individuals may have various levels of education, training, and expertise, and their roles and responsibilities will depend on the specific research study and their individual qualifications. It is important for research personnel to adhere to ethical guidelines and regulations in order to ensure the integrity and validity of research findings.

Nursing research is a scientific investigation that systematically studies nursing phenomena and related outcomes to establish best practices, improve patient care, and advance the profession of nursing. It utilizes various research methods and theories to address questions and problems relevant to nursing practice, education, administration, and policy-making. The ultimate goal of nursing research is to generate evidence-based knowledge that informs nursing interventions, enhances patient outcomes, and contributes to the development of nursing science.

Health services research (HSR) is a multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies, and personal behaviors affect access to healthcare, the quality and cost of care, and ultimately, our health and well-being. The goal of HSR is to inform policy and practice, improve system performance, and enhance the health and well-being of individuals and communities. It involves the use of various research methods, including epidemiology, biostatistics, economics, sociology, management science, political science, and psychology, to answer questions about the healthcare system and how it can be improved.

Examples of HSR topics include:

* Evaluating the effectiveness and cost-effectiveness of different healthcare interventions and technologies
* Studying patient-centered care and patient experiences with the healthcare system
* Examining healthcare workforce issues, such as shortages of primary care providers or the impact of nurse-to-patient ratios on patient outcomes
* Investigating the impact of health insurance design and financing systems on access to care and health disparities
* Analyzing the organization and delivery of healthcare services in different settings, such as hospitals, clinics, and long-term care facilities
* Identifying best practices for improving healthcare quality and safety, reducing medical errors, and eliminating wasteful or unnecessary care.

Translational medical research, also known as "translational research," refers to the process of turning basic scientific discoveries into clinical interventions that improve human health and well-being. This type of research aims to "translate" findings from laboratory, animal, or cellular studies into practical applications for the prevention, diagnosis, and treatment of human diseases.

Translational medical research typically involves a multidisciplinary approach, bringing together researchers from various fields such as biology, chemistry, engineering, genetics, and medicine to work collaboratively on solving complex health problems. The process often includes several stages, including:

1. Identifying basic scientific discoveries that have the potential to be translated into clinical applications.
2. Developing and optimizing new diagnostic tools, drugs, or therapies based on these discoveries.
3. Conducting preclinical studies in the laboratory or with animal models to evaluate the safety and efficacy of these interventions.
4. Designing and implementing clinical trials to test the effectiveness and safety of the new interventions in human patients.
5. Disseminating research findings to the scientific community, healthcare providers, and the public to facilitate the adoption of new practices or treatments.

Translational medical research is essential for bridging the gap between basic scientific discoveries and clinical applications, ultimately improving patient care and outcomes.

"Gluten" is not strictly defined as a medical term, but it refers to a group of proteins found in certain grains, including wheat, barley, and rye. Gluten gives these grains their elasticity and helps them maintain their shape, making it possible to bake breads and other baked goods.

From a medical perspective, gluten is significant because some people have adverse reactions to it. The two main conditions related to gluten are celiac disease and non-celiac gluten sensitivity. In both cases, consuming gluten can lead to various symptoms such as gastrointestinal distress, fatigue, and skin rashes.

Celiac disease is an autoimmune disorder where the ingestion of gluten causes damage to the small intestine lining, impairing nutrient absorption. On the other hand, non-celiac gluten sensitivity does not involve an immune response or intestinal damage but can still cause uncomfortable symptoms in some individuals.

It is essential to understand that a gluten-free diet should be medically recommended and supervised by healthcare professionals for those diagnosed with celiac disease or non-celiac gluten sensitivity, as it may lead to nutritional deficiencies if not properly managed.

Celiac disease is a genetic autoimmune disorder in which the consumption of gluten, a protein found in wheat, barley, and rye, leads to damage in the small intestine. In people with celiac disease, their immune system reacts to gluten by attacking the lining of the small intestine, leading to inflammation and destruction of the villi - finger-like projections that help absorb nutrients from food.

This damage can result in various symptoms such as diarrhea, bloating, fatigue, anemia, and malnutrition. Over time, if left untreated, celiac disease can lead to serious health complications, including osteoporosis, infertility, neurological disorders, and even certain types of cancer.

The only treatment for celiac disease is a strict gluten-free diet, which involves avoiding all foods, beverages, and products that contain gluten. With proper management, individuals with celiac disease can lead healthy lives and prevent further intestinal damage and related health complications.

Gliadin is a protein fraction found in gluten, a complex protein that's present in certain grains such as wheat, barley, and rye. It is particularly known for its role in celiac disease, a disorder where the ingestion of gluten leads to an immune response that damages the lining of the small intestine.

Gliadin, along with another protein fraction called glutenin, makes up gluten. Gliadin is responsible for the elastic properties of dough. When water is added to flour and mixed, these proteins form a sticky network that gives dough its characteristic texture and allows it to rise and maintain its shape during baking.

In individuals with celiac disease, the immune system recognizes gliadin as a foreign invader and mounts an immune response against it. This response leads to inflammation and damage in the small intestine, preventing the absorption of nutrients from food. Over time, this can lead to various health complications if not properly managed through a gluten-free diet.

A gluten-free diet is a diet that excludes the consumption of gluten, a protein found in wheat, barley, and rye. This type of diet is often recommended for individuals with celiac disease, non-celiac gluten sensitivity, or wheat allergies. Adhering to a strict gluten-free diet can help manage symptoms, heal intestinal damage, and prevent further complications associated with these conditions.

The medical definition of 'Diet, Gluten-Free' includes:

1. Celiac Disease: An autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. Following a gluten-free diet is crucial for individuals with celiac disease to prevent symptoms and associated health complications.
2. Non-Celiac Gluten Sensitivity (NCGS): A condition where individuals experience adverse reactions to gluten, but do not test positive for celiac disease or wheat allergy. A gluten-free diet can help alleviate symptoms in those with NCGS.
3. Wheat Allergy: An allergic reaction to proteins found in wheat, which may include gluten. Excluding gluten from the diet can help manage symptoms in individuals with wheat allergy.
4. Dermatitis Herpetiformis (DH): A skin manifestation of celiac disease characterized by an itchy, blistering rash. A gluten-free diet is often recommended to control DH symptoms and prevent intestinal damage.
5. Gluten Ataxia: A neurological disorder associated with celiac disease where gluten ingestion can cause issues with balance, coordination, and speech. A gluten-free diet may help improve these symptoms in individuals with gluten ataxia.

It is essential to consult a healthcare professional or a registered dietitian for guidance on following a gluten-free diet to ensure proper nutrition and to avoid cross-contamination from gluten sources.

Wheat hypersensitivity is a general term that refers to adverse reactions to wheat proteins. It can be divided into two main types: food allergies and non-celiac gluten or wheat sensitivity (NCGWS).

1. Food Allergy: This is an immune-mediated reaction to one or more wheat proteins, such as gliadin, glutenin, albumin, and globulin. In this case, the body's immune system mistakenly identifies these proteins as harmful and produces antibodies (IgE) against them. This can lead to symptoms like hives, swelling, itching, difficulty breathing, or anaphylaxis shortly after ingesting wheat.

2. Non-Celiac Gluten or Wheat Sensitivity: This is a non-immune mediated reaction to wheat proteins, where the body does not produce IgE antibodies. The exact mechanisms are not fully understood, but it's believed that other components of wheat, such as fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) or amylase-trypsin inhibitors (ATIs), may contribute to the symptoms. These can include gastrointestinal issues like bloating, diarrhea, and stomach pain, as well as non-gastrointestinal symptoms such as fatigue, headaches, and joint pain. Unlike celiac disease, NCGWS does not cause damage to the small intestine.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Dermatitis herpetiformis (DH) is a chronic, autoimmune blistering skin disorder that is characterized by the presence of symmetrical, pruritic (itchy), papulo-vesicular (papules and small fluid-filled blisters) eruptions on the extensor surfaces of the body, such as the elbows, knees, buttocks, and shoulders. It is often associated with gluten sensitivity or celiac disease, a condition that causes an abnormal immune response to gluten, a protein found in wheat, barley, and rye.

The exact cause of DH is not fully understood, but it is believed to result from the interaction between genetic, environmental, and immunological factors. The disorder is characterized by the presence of IgA antibodies in the skin, which trigger an immune response that leads to the formation of the characteristic rash.

DH is typically treated with a gluten-free diet, which can help to control the symptoms and prevent complications such as malabsorption and nutritional deficiencies. Medications such as dapsone may also be used to control the itching and blistering associated with the disorder. In some cases, topical corticosteroids or other anti-inflammatory medications may be prescribed to help manage symptoms.

It is important to note that DH is a chronic condition that requires ongoing management and monitoring. People with DH should work closely with their healthcare provider to develop an appropriate treatment plan and monitor their progress over time.