Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Laboratories: Facilities equipped to carry out investigative procedures.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Image Interpretation, Computer-Assisted: Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.Diagnostic Techniques, Ophthalmological: Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Calibration: Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.Automation: Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Tomography, Optical Coherence: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.Image Enhancement: Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Translations: Products resulting from the conversion of one language to another.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Equipment Design: Methods of creating machines and devices.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Radiographic Image Interpretation, Computer-Assisted: Computer systems or networks designed to provide radiographic interpretive information.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Respiratory-Gated Imaging Techniques: Timing the acquisition of imaging data to specific points in the breathing cycle to minimize image blurring and other motion artifacts. The images are used diagnostically and also interventionally to coordinate radiation treatment beam on/off cycles to protect healthy tissues when they move into the beam field during different times in the breathing cycle.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Phantoms, Imaging: Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)Anatomic Landmarks: Reference points located by visual inspection, palpation, or computer assistance, that are useful in localizing structures on or within the human body.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Diet Records: Records of nutrient intake over a specific period of time, usually kept by the patient.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Electrophoresis, Capillary: A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)Automation, Laboratory: Controlled operations of analytic or diagnostic processes, or systems by mechanical or electronic devices.Diet Surveys: Systematic collections of factual data pertaining to the diet of a human population within a given geographic area.Methods: A series of steps taken in order to conduct research.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Contrast Media: Substances used to allow enhanced visualization of tissues.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Pathology, Clinical: A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)Language: A verbal or nonverbal means of communicating ideas or feelings.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Optic Disk: The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.Limit of Detection: Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.Photogrammetry: Making measurements by the use of stereoscopic photographs.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Autoanalysis: Method of analyzing chemicals using automation.Tomography: Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Capillary Electrochromatography: A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.Corneal Pachymetry: Measurement of the thickness of the CORNEA.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Cephalometry: The measurement of the dimensions of the HEAD.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Laboratory Proficiency Testing: Assessments aimed at determining agreement in diagnostic test results among laboratories. Identical survey samples are distributed to participating laboratories, with results stratified according to testing methodologies.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Data Interpretation, Statistical: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Statistics as Topic: The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.Blood Chemical Analysis: An examination of chemicals in the blood.Pathology: A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Head: The upper part of the human body, or the front or upper part of the body of an animal, typically separated from the rest of the body by a neck, and containing the brain, mouth, and sense organs.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Equipment Failure Analysis: The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.Ultrasonography, Doppler: Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)Radiography, Dental, Digital: A rapid, low-dose, digital imaging system using a small intraoral sensor instead of radiographic film, an intensifying screen, and a charge-coupled device. It presents the possibility of reduced patient exposure and minimal distortion, although resolution and latitude are inferior to standard dental radiography. A receiver is placed in the mouth, routing signals to a computer which images the signals on a screen or in print. It includes digitizing from x-ray film or any other detector. (From MEDLINE abstracts; personal communication from Dr. Charles Berthold, NIDR)Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Tonometry, Ocular: Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Macula Lutea: An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)Artifacts: Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.Microchemistry: The development and use of techniques and equipment to study or perform chemical reactions, with small quantities of materials, frequently less than a milligram or a milliliter.Radiography, Dental: Radiographic techniques used in dentistry.Arthrometry, Articular: Measurements of joint flexibility (RANGE OF MOTION, ARTICULAR), usually by employing an angle-measuring device (arthrometer). Arthrometry is used to measure ligamentous laxity and stability. It is often used to evaluate the outcome of ANTERIOR CRUCIATE LIGAMENT replacement surgery.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Fourier Analysis: Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)Posture: The position or attitude of the body.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Ultrasonography, Prenatal: The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.Magnetic Resonance Imaging, Cine: A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.Cone-Beam Computed Tomography: Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.Analytic Sample Preparation Methods: Use of various chemical separation and extraction methods, such as SOLID PHASE EXTRACTION; CHROMATOGRAPHY; and SUPERCRITICAL FLUID EXTRACTION; to prepare samples for analytical measurement of components.Indicator Dilution Techniques: Methods for assessing flow through a system by injection of a known quantity of an indicator, such as a dye, radionuclide, or chilled liquid, into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)Seveso Accidental Release: 1976 accidental release of DIOXINS from a manufacturing facility in Seveso, ITALY following an equipment failure.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Oxygen Radioisotopes: Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.ComputersWeights and Measures: Measuring and weighing systems and processes.Breath Holding: An involuntary or voluntary pause in breathing, sometimes accompanied by loss of consciousness.Anatomy, Cross-Sectional: Descriptive anatomy based on three-dimensional imaging (IMAGING, THREE-DIMENSIONAL) of the body, organs, and structures using a series of computer multiplane sections, displayed by transverse, coronal, and sagittal analyses. It is essential to accurate interpretation by the radiologist of such techniques as ultrasonic diagnosis, MAGNETIC RESONANCE IMAGING, and computed tomography (TOMOGRAPHY, X-RAY COMPUTED). (From Lane & Sharfaei, Modern Sectional Anatomy, 1992, Preface)Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Fundus Oculi: The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)Radiographic Image Enhancement: Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.Bacteriological Techniques: Techniques used in studying bacteria.Plethysmography: Recording of change in the size of a part as modified by the circulation in it.Moire Topography: A method of three-dimensional morphometry in which contour maps are produced from the overlapping interference fringes created when an object is illuminated by beams of coherent light issuing from two different point sources.Gated Blood-Pool Imaging: Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).Interferometry: Measurement of distances or movements by means of the phenomena caused by the interference of two rays of light (optical interferometry) or of sound (acoustic interferometry).Perfusion Imaging: The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.Healthy Volunteers: Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from, accessed 2/14/2013)Diagnosis, Computer-Assisted: Application of computer programs designed to assist the physician in solving a diagnostic problem.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Colorimetry: Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Technetium Tc 99m Mertiatide: A technetium diagnostic aid used in renal function determination.Conductometry: Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Technetium Tc 99m Diethyl-iminodiacetic Acid: A nontoxic radiopharmaceutical that is used in the clinical evaluation of hepatobiliary disorders in humans.Microcomputers: Small computers using LSI (large-scale integration) microprocessor chips as the CPU (central processing unit) and semiconductor memories for compact, inexpensive storage of program instructions and data. They are smaller and less expensive than minicomputers and are usually built into a dedicated system where they are optimized for a particular application. "Microprocessor" may refer to just the CPU or the entire microcomputer.Breath Tests: Any tests done on exhaled air.Tomography, Emission-Computed: Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Software Validation: The act of testing the software for compliance with a standard.Physical Examination: Systematic and thorough inspection of the patient for physical signs of disease or abnormality.Anterior Chamber: The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)Automatic Data Processing: Data processing largely performed by automatic means.Smiling: A facial expression which may denote feelings of pleasure, affection, amusement, etc.DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Nucleic Acid Amplification Techniques: Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Radiographic Magnification: Use of optic and geometric techniques to enhance radiographic image quality and interpretation. It includes use of microfocal X-ray tubes and intensifying fluoroscopic screens.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Blood Pressure Determination: Techniques for measuring blood pressure.Molecular Diagnostic Techniques: MOLECULAR BIOLOGY techniques used in the diagnosis of disease.Single-Blind Method: A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.X-Ray Intensifying Screens: Screens which absorb the energy in the x-ray beam that has penetrated the patient and convert this energy into a light pattern which has as nearly as possible the same information as the original x-ray beam. The more light a screen produces for a given input of x-radiation, the less x-ray exposure and thus shorter exposure time are needed to expose the film. In most film-screen systems, the film is sandwiched between two screens in a cassette so that the emulsion on each side is exposed to the light from its contiguous screen.Pulsatile Flow: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.Gonioscopy: Examination of the angle of the anterior chamber of the eye with a specialized optical instrument (gonioscope) or a contact prism lens.Intraocular Pressure: The pressure of the fluids in the eye.Breast Neoplasms: Tumors or cancer of the human BREAST.Photometry: Measurement of the various properties of light.Diet: Regular course of eating and drinking adopted by a person or animal.Diagnostic Imaging: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.Paraffin Embedding: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Protein Array Analysis: Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Tissue Fixation: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.Proteome: The protein complement of an organism coded for by its genome.Enzymes, Immobilized: Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with little or no loss of their catalytic activity. Since they can be reused continuously, immobilized enzymes have found wide application in the industrial, medical and research fields.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Cardiac-Gated Imaging Techniques: Timing the acquisition of imaging data to specific points in the cardiac cycle to minimize image blurring and other motion artifacts.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Dental Instruments: Hand-held tools or implements especially used by dental professionals for the performance of clinical tasks.Photography, Dental: Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.BrazilMandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Perinatology: The branch of medicine dealing with the fetus and infant during the perinatal period. The perinatal period begins with the twenty-eighth week of gestation and ends twenty-eight days after birth. (From Dorland, 27th ed)Cyclopentolate: A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.Fluorine Radioisotopes: Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.Dental Caries Activity Tests: Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.

*  can anyone believe your results? (reproducibility)

One Response to can anyone believe your results? (reproducibility). * Pingback: The GNU Scientific Library: An interview with ... can anyone believe your results? (reproducibility). Posted on 2011-06-11 by markgalassi ... I have the impression that a lot of papers I look at have results that are not reproducible. If the papers made a claim to a ... Much has been written about Fleischmann and Pons, but I have not found if their problem was lack of reproducibility (so they ...

*  Column Leaching Tests for groundwater risk assessment: concept, interpretation of results, and reproducibility

... ...

*  The IFCC Reference Measurement System for HbA1c: A 6-Year Progress Report | Clinical Chemistry

long-term trend, bias, and reproducibility results for network laboratories. Table 3⇓ shows the results of long-term evaluation ... long-term trend, bias, and reproducibility results for network laboratories. A single intercomparison study is the forum for ... reproducibility and stability of calibrators and controls. Long-term reproducibility is the cornerstone of the management of ... 1⇑ . Thirteen laboratories (5 HPLC-MS and 8 HPLC-capillary electrophoresis) submitted results. Twelve of these results were ...

*  Overexpression of thePHO84gene causes heavy metal accumulation and induces Ire1p-dependent unfolded protein response...

Reproducibility of the results. All experiments were repeated, independently, on three different days. For each individual ... Overexpressing PHO84 in ire1Δ cells results in enhanced metal accumulation. As the IRE1 gene disruption resulted in increased ... Results. Overexpression of PHO84 from a GAL1 promoter augments the heavy metal accumulation by yeast cells. Knockout pho84Δ ... 3b). The results were reproducible, and statistical analysis of data obtained from similar experiments performed on different ...

*  SPEC CPU2000 Config files

the key to result reproducibility * the repository for all information unique to a vendor/system ... cd $SPEC mv result result_old mkdir result On NT, you could say: cd %SPEC% rename result result_old mkdir result E. Finding the ... result/*asc , head -1 ../result/CFP2000.111.asc % grep ++ ../result/CFP2000.111.asc ++ hi ++ Alex, ++ how ++ are ++ you? % You ... SPEC/result. (Unix) or %SPEC%\result. (NT) contains reports and log files. When you are doing a build, you will probably find ...

*  "The PCL: YV and recidivism in male and female juveniles: a follow-up into young adulthood" by Gina M....

Reproducibility of Results; Risk Assessment; Sex Factors; Violence ...

*  Where Should Automated Blood Pressures be Done in Primary Care Offices? - Full Text View -

Regression analysis will be undertaken to compare the measures and results will be adjusted for clustering effect. All tests ... using the results of our pilot study. We consider differences of less than 5 mm Hg in systolic blood pressure to be clinically ...

*  Optimisation of the membrane-assisted passive sampler and its comparison with solid phase extraction technique

Reproducibility of the passive sampler. Table 2 indicates the reproducibility results of the passive sampler in deionised water ... Reproducibility of the passive sampler. To test for reproducibility in wastewater and deionised water samples, 3 parallel ... The results indicate that the type of cover is very important as it can affect the mass transfer process to the sampler. In ... The same results were obtained from deionised water spiked with 20 mg·. -1 humic substances (Fig. 6). The differences seen in ...

*  Center for Theoretical & Mathematical Sciences » People

Reproducibility of Results • Respiration • Rhodobacter capsulatus • RNA, Messenger • S-Adenosylhomocysteine • S- ...

*  Diseño de una escala para evaluar calidad metodológica de estudios de pruebas diagnósticas. Estudio piloto

Palabras clave : Epidemiologic Methods; methodological quality; Reproducibility of Results; Reliability, scales. · resumen en ... Results: The created scale has 9 items grouped into three domains. The ICC observed was 1.0 for the domain 1, 0.90 for the ... Aim: To report the results of the generation of items and domains of a scale to determine MQ in studies of DT and to determine ...

*  Bias Associated With Self-Report of Prior Screening Mammography | Cancer Epidemiology, Biomarkers & Prevention

reproducibility of results. Introduction. National estimates of the use of cancer screening procedures are based primarily on ... We use a screening dissemination model to generate simulated results for the U.S. population and compare these results with ... Results. Figure 1 shows the percent of women who reported having a mammogram for any reason and specifically for screening in ... Results from the model are compared with national estimates of mammography use from the 2000 NHIS. A detailed description of ...

*  Patent US20030138674 - Electrochemical methods for generation of a biological proton motive force ... - Google Patents

Chemicals and Reproducibility of Results * [0082] All chemicals were reagent grade and gases were purchased from AGA Chemicals ... As the results presented in FIG. 13, the increased ethanol concentration adversely affected the reaction rate and resulted in a ... Our results also show that low biomass concentrations resulted in a significantly enhanced specific reaction rate (6.46 mg/L/ ... The results show that 0.13 g/L of the product was produced with 3 volt of electricity after 8 hour incubation, whereas only a ...

*  TRB@ | Cancer Genetics Web

RESULTS: High and middle dose JJR could postpone the growth of LC volume (P < 0.05), with equivalent liver index and thymus ... RESULTS: (1)When the DNA concentration was diluted to 50-100 ng/μl from 100-500 ng/μl, the proportion of the longest ... The results implicate that the uncoupled and aberrant V(D)J cleavages may contribute to double-strand break-mediated genome ... Loss of E2A results in enhanced proliferation and cell cycle progression via derepression of the protooncogene MYC and the cell ...

*  Cryopreservation of precision-cut tissue slices for application in drug metabolism research.

Reproducibility of Results. Tissue Banks. Tissue Fixation / methods*. Water. Chemical. Reg. No./Substance: 7732-18-5/Water ...

*  Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans.

Reproducibility of Results. Tetrazoles / administration & dosage, pharmacokinetics*, pharmacology. Valine / administration & ...

*  Early pregnancy diagnosis in goats by determination of pregnancy-associated glycoprotein concentrations in plasma samples.

Reproducibility of Results. Sensitivity and Specificity. Time Factors. Chemical. Reg. No./Substance: 0/Glycoproteins; 0/ ... 18382999 - Preliminary results of fetal rhc examination in plasma of pregnant women with anti-c.. 11890409 - Interrelationships ...

*  Grading of aortic valve stenosis at 64-slice spiral computed tomography: comparison with transthoracic echocardiography and...

Reproducibility of Results. Sensitivity and Specificity. Tomography, X-Ray Computed / methods*, standards. ... RESULTS: Series of AVA measurements correlated well between MSCT and TTE (r = 0.86) and between MSCT and CATH (r = 0.90). ...

*  Measuring the habitat as an indicator of socioeconomic position: methodology and its association with hypertension.

Reproducibility of Results. Residence Characteristics*. Social Class. Socioeconomic Factors. Switzerland. Comments/Corrections ... MAIN RESULTS: The SSH index was highly reproducible (kappa=0.8). Concordance of SSH with education or occupation was good for ...

*  CDH11 | Cancer Genetics Web

Our results for the first time indicate that miR-27b acting as an oncogene may play an important role in the progression of ... RESULTS: Using a fold-change of 1.4 or more, we found 132 and 125 differentially expressed proteins in whole-cell extracts and ... RESULTS: Comparative analysis showed higher gene expression of EPCAM, CD49f, CDH1 and KRTs for normal MEC lines; MES lines e.g ... The results obtained from this study may improve our understanding of the role of these candidate miRNAs and their target genes ...

*  Time series observation based InfraRed Epifluorescence Microscopic (TIREM) approach for accurate enumeration of...

Reproducibility of Results. Roseobacter / isolation & purification. Seawater / microbiology*. Sphingomonadaceae / isolation & ...

*  Thrombosis and subsequent recanalization of a ruptured intracranial aneurysm in 2 children, demonstrating the value of...

Reproducibility of Results. Subarachnoid Hemorrhage / radiography*. Tegmentum Mesencephali / blood supply, radiography. From ...

*  Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation.

Reproducibility of Results. Sulfonamides / blood, pharmacology*. Sumatriptan. Vasoconstrictor Agents / pharmacology. Chemical. ... METHODS AND RESULTS: Ten patients undergoing diagnostic coronary arteriography were studied with digital subtraction ...

*  Investigation of the value of a photographic tool to measure self-perception of enamel opacities.

Reproducibility of Results. Self Concept. Grant Support. ID/Acronym/Agency: DHCS/05/05/008//Department of Health ... RESULTS: The tool was feasible to use, with 74% of pupils making a response to the first question about the presence of white ... The results clearly demonstrate (see Table 2) that there is an association between the self-perception of the presence of ... Results The teams in three PCOs took part in additional activities to measure the effectiveness of the self-perception tool ...

*  Comparative predictive and diagnostic value of flow-mediated vasodilation in the brachial artery and intima media thickness of...

Reproducibility of Results. Severity of Illness Index*. Tunica Intima / ultrasonography. Tunica Media / ultrasonography. ... RESULTS: Seventy-three patients had significant CAD, and 30 patients showed no CAD (NL). FMD was significantly lower and IMT ...

*  MicroRNA miR-1271 | Cancer Genetics Web

RESULTS: The ovarian cancer tissue and cell lines showed low levels of miR-1271. Low levels of miR-1271 in ovarian cancer ... RESULTS: MiR-1271 was downregulated in both GC tissues and GC cell lines. The expression of miR-1271 was inversely correlated ... RESULTS: We found a significant up-regulation of miR-1247-5p in castration-resistant prostate cancer (CRPC) samples compared to ... In addition, our results showed that miR-1271 expression levels were decreased while ZEB1 and TWIST1 expression levels were ...

Generalizability theory: Generalizability theory, or G Theory, is a statistical framework for conceptualizing, investigating, and designing reliable observations. It is used to determine the reliability (i.Assay sensitivity: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.Image fusion: In computer vision, Multisensor Image fusion is the process of combining relevant information from two or more images into a single image.Haghighat, M.Certified reference materials: Certified Reference Materials (CRMs) are ‘controls’ or standards used to check the quality and metrological traceability of products, to validate analytical measurement methods, or for the calibration of instruments.Volume rendering: 250px|thumb| A volume rendered cadaver head using view-aligned [[texture mapping and diffuse reflection]]Analytical quality control: Analytical quality control, commonly shortened to AQC refers to all those processes and procedures designed to ensure that the results of laboratory analysis are consistent, comparable, accurate and within specified limits of precision.analytical quality control (AQC) program to ensure the highest level of confidence in reported data Constituents submitted to the analytical laboratory must be accurately described to avoid faulty interpretations, approximations, or incorrect results.Electron Microscopy Center: The Electron Microscopy Center is a scientific user facility at Argonne National Laboratory. The EMC works to solve materials problems using their unique capabilities for electron beam characterization.CalibrationXAP Home Automation protocol: xAP is an open protocol used for home automation and supports integration of telemetry and control devices primarily within the home. Common communications networks include RS232, RS485, Ethernet& wireless.HyperintensityClonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.Coherence theory: In physics, coherence theory is the study of optical effects arising from partially coherent light and radio sources. Partially coherent sources are sources where the coherence time or coherence length are limited by bandwidth, by thermal noise, or by other effect.Outline of photography: The following outline is provided as an overview of and topical guide to photography:Bioline Reagents: Bioline Reagents is a primary manufacturer and developerBioline: The PCR Company | Company Profile of a wide range of specialised molecular biology products for the life science industry and research markets. It manufactures reagents including ultra-pure nucleotides, DNA polymerases and mixes, DNA markers, competent cells, products for RNA analysis and other general reagents for molecular biology.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingBeta encoder: A beta encoder is an analog to digital conversion (A/D) system in which a real number in the unit interval is represented by a finite representation of a sequence in base beta, with beta being a real number between 1 and 2. Beta encoders are an alternative to traditional approaches to pulse code modulation.Superficial velocity: Superficial velocity (or superficial flow velocity), in engineering of multiphase flows and flows in porous media, is a hypothetical (artificial) flow velocity calculated as if the given phase or fluid were the only one flowing or present in a given cross sectional area. Other phases, particles, the skeleton of the porous medium, etc.Feasibility Study (The Outer Limits): "Feasibility Study" is an episode of The Outer Limits television show. It was first broadcast on 11 July 1997, during the third season.Imaging phantom: Phantom}}Mac OS X Server 1.0Cellular microarray: A cellular microarray is a laboratory tool that allows for the multiplex interrogation of living cells on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots.Closed-ended question: A closed-ended question is a question format that limits respondents with a list of answer choices from which they must choose to answer the question.Dillman D.Capillary electrophoresis–mass spectrometry: Capillary electrophoresis–mass spectrometry (CE-MS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry. CE-MS combines advantages of both CE and MS to provide high separation efficiency and molecular mass information in a single analysis.Journal of Laboratory Automation: The Journal of Laboratory Automation is a bimonthly peer-reviewed scientific journal published by the Society for Laboratory Automation and Screening in partnership with SAGE Publications. The journal's editor-in-chief is Dean Ho (University of California Los Angeles).Dense artery sign: In medicine, the dense artery sign or hyperdense artery sign is a radiologic sign seen on computer tomography (CT) scans suggestive of early ischemic stroke. In earlier studies of medical imaging in patients with strokes, it was the earliest sign of ischemic stroke in a significant minority of cases.Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?High-performance liquid chromatography: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material.Schering AGNerve fiber layer: The retinal nerve fiber layer (nerve fiber layer, stratum opticum, RNFL) is formed by the expansion of the fibers of the optic nerve; it is thickest near the porus opticus, gradually diminishing toward the ora serrata.Eggs per gram: Eggs per gram (EPG) is a laboratory test that determines the number of eggs per gram of feces in patients suspected of having a parasitological infection, such as schistosomiasis. EPG is the primary diagnostic method for schistosomiasis, as opposed to a blood test.Daniel Kane (linguist): Daniel Kane is an Australian linguist, one of the world's foremost authorities on the extinct Jurchen and Khitan languages and their scripts.Thermal cyclerCharles D. Phelps: Charles Dexter Phelps (September 16, 1937 – September 13, 1985) was a prominent American medical doctor, professor, and researcher in the field of ophthalmology. The clinical studies he oversaw contributed to significant advances in the scientific understanding and surgical and pharmacological treatment of glaucoma.Optic disc: The optic disc or optic nerve head is the point of exit for ganglion cell axons leaving the eye. BecausePhotogrammetry: Photogrammetry is the science of making measurements from photographs, especially for recovering the exact positions of surface points. Moreover, it may be used to recover the motion pathways of designated reference points located on any moving object, on its components and in the immediately adjacent environment.Kodak DCS 300 series: The Kodak DCS 300 series comprised two cameras, the DCS 315 and DCS 330. They were professional-level digital SLR cameras built by Eastman Kodak's Kodak Professional Imaging Solutions division.Electrical impedance tomography: Electrical Impedance Tomography (EIT) is a non-invasive medical imaging technique in which an image of the conductivity or permittivity of part of the body is inferred from surface electrode measurements. Electrical conductivity depends on free ion content and differs considerably between various biological tissues (absolute EIT) or different functional states of one and the same tissue or organ (relative or functional EIT).Avid Radiopharmaceuticals: Avid Radiopharmaceuticals is an American company, founded by Dr. Daniel Skovronsky, and based at the University City Science Center research campus in Philadelphia, Pennsylvania.Capillary electrochromatography: Capillary electrochromatography (CEC) is a chromatographic technique in which the mobile phase is driven through the chromatographic bed by electroosmosis. Capillary electrochromatography is a combination of two analytical techniques, High performance liquid chromatography and capillary electrophoresis.Atomic mass: right |thumb|200px|Stylized [[lithium-7 atom: 3 protons, 4 neutrons, & 3 electrons (total electrons are ~1/4300th of the mass of the nucleus). It has a mass of 7.Cephalogram: A cephalogram is an X-ray of the craniofacial area. A cephalometric analysis could be used as means for measuring growth in children.Knee pain: Knee pain is a common complaint for many people. There are several factors that can cause knee pain.Brain positron emission tomography: Positron emission tomography (PET) measures emissions from radioactively labeled metabolically active chemicals that have been injected into the bloodstream. The emission data are computer-processed to produce multi-dimensional images of the distribution of the chemicals throughout the brain.Regularized canonical correlation analysis: Regularized canonical correlation analysis is a way of using ridge regression to solve the singularity problem in the cross-covariance matrices of canonical correlation analysis. By converting \operatorname{cov}(X, X) and \operatorname{cov}(Y, Y) into \operatorname{cov}(X, X) + \lambda I_X and \operatorname{cov}(Y, Y) + \lambda I_Y, it ensures that the above matrices will have reliable inverses.Proteomics Standards Initiative: The Proteomics Standards Initiative (PSI) is a working group of Human Proteome Organization. It aims to define data standards for proteomics in order to facilitate data comparison, exchange and verification.Cable fault location: Cable fault location is the process of locating periodic faults, such as insulation faults in underground cables, and is an application of electrical measurement systems. In this process, mobile shock discharge generators are among the devices used.DBFS: Decibels relative to full scale, commonly abbreviated dBFS, measures decibel amplitude levels in digital systems such as pulse-code modulation (PCM) which have a defined maximum available peak level.Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Fluorescent glucose biosensor: Fluorescent glucose biosensors are devices that measure the concentration of glucose in diabetic patients by means of sensitive protein that relays the concentration by means of fluorescence, an alternative to amperometric sension of glucose. No device has yet entered the medical market,No fluorescent biosensor has yet entered the medical market, however, in the market for research tools several fluorescent biosensors are present, such as a kit using [Vibrio fischeri] but, due to the prevalence of diabetes, it is the prime drive in the construction of fluorescent biosensors.Imbert-Fick law: The Imbert-Fick "law" was invented by Hans Goldmann (1899–1991) to give his newly marketed tonometer (with the help of the Haag-Streit Company) a quasi-scientific basis; it is mentioned in the ophthalmic and optometric literature, but not in any books of physics. According to Goldmann,Goldmann H.Reference electrode: A reference electrode is an electrode which has a stable and well-known electrode potential. The high stability of the electrode potential is usually reached by employing a redox system with constant (buffered or saturated) concentrations of each participants of the redox reaction.EEGLAB: EEGLAB is a MATLAB toolbox distributed under the free GNU GPL license for processing data from electroencephalography (EEG), magnetoencephalography (MEG), and other electrophysiological signals. Along with all the basic processing tools, EEGLAB implements independent component analysis (ICA), time/frequency analysis, artifact rejection, and several modes of data visualization.Dental radiographyGoniometerAbdominal ultrasonographyDemodulation: Demodulation is the act of extracting the original information-bearing signal from a modulated carrier wave. A demodulator is an electronic circuit (or computer program in a software-defined radio) that is used to recover the information content from the modulated carrier wave.Fourier operator: The Fourier operator is the kernel of the Fredholm integral of the first kind that defines the continuous Fourier transform.Riding-like sittingCine Capari: The Cine Capari is a domesticated breed of sheep originating from Aydin Province in Turkey. In 1998, there were 300 Cine Capari and the population was decreasing.PlanmecaCatalytic cycle: A catalytic cycle in chemistry is a term for a multistep reaction mechanism that involves a catalyst.Kinetics of catalytic reactions 2005 M.Calculator: An electronic calculator is a small, portable electronic device used to perform both basic operations of arithmetic and complex mathematical operations.

(1/49462) Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label.

A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair.  (+info)

(2/49462) Urinary lithium: distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry.

Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples. The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans. Urine samples obtained from male workers (n = 86) who had not been exposed to lithium were used for the determination of this element by ICPAES. The obtained concentrations were corrected using a specific gravity of 1.024. The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread. Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 microg/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 microg/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure. Calibration curves obtained for lithium standards had good sensitivity and linearity. Good reproducibility was assessed by lithium addition to urine samples. It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk.  (+info)

(3/49462) Transient and permanent deficits in motion perception after lesions of cortical areas MT and MST in the macaque monkey.

We examined the nature and the selectivity of the motion deficits produced by lesions of extrastriate areas MT and MST. Lesions were made by injecting ibotenic acid into the representation of the left visual field in two macaque monkeys. The monkeys discriminated two stimuli that differed either in stimulus direction or orientation. Direction and orientation discrimination were assessed by measuring thresholds with gratings and random-dots placed in the intact or lesioned visual fields. At the start of behavioral testing, we found pronounced, motion-specific deficits in thresholds for all types of moving stimuli, including pronounced elevations in contrast thresholds and in signal-to-noise thresholds measured with moving gratings, as well as deficits in direction range thresholds and motion coherence measured with random-dot stimuli. In addition, the accuracy of direction discrimination was reduced at smaller spatial displacements (i.e. step sizes), suggesting an increase in spatial scale of the residual directional mechanism. Subsequent improvements in thresholds were seen with all motion stimuli, as behavioral training progressed, and these improvements occurred only with extensive behavioral testing in the lesioned visual field. These improvements were particularly pronounced for stimuli not masked by noise. On the other hand, deficits in the ability to extract motion from noisy stimuli and in the accuracy of direction discrimination persisted despite extensive behavioral training. These results demonstrate the importance of areas MT and MST for the perception of motion direction, particularly in the presence of noise. In addition, they provide evidence for the importance of behavioral training for functional recovery after cortical lesions. The data also strongly support the idea of functional specialization of areas MT and MST for motion processing.  (+info)

(4/49462) Comparative efficacy of positron emission tomography with FDG and computed tomographic scanning in preoperative staging of non-small cell lung cancer.

OBJECTIVE: To determine the sensitivity, specificity, and accuracy of positron emission tomography with 2-fluorine-18-fluorodeoxyglucose (PET-FDG) in the preoperative staging (N and M staging) of patients with lung cancer. The authors wanted to compare the efficacy of PET scanning with currently used computed tomography (CT) scanning. MATERIALS AND METHODS: Results of whole-body PET-FDG imaging and CT scans were compared with histologic findings for the presence or absence of lymph node disease or metastatic sites. Sampling of mediastinal lymph nodes was performed using mediastinoscopy or thoracotomy. RESULTS: PET-FDG imaging was significantly more sensitive, specific, and accurate for detecting N disease than CT. PET changed N staging in 35% and M staging in 11% of patients. CT scans helped in accurate anatomic localization of 6/57 PET lymph node abnormalities. CONCLUSION: PET-FDG is a reliable method for preoperative staging of patients with lung cancer and would help to optimize management of these patients. Accurate lymph node staging of lung cancer may be ideally performed by simultaneous review of PET and CT scans.  (+info)

(5/49462) Permanent work incapacity, mortality and survival without work incapacity among occupations and social classes: a cohort study of ageing men in Geneva.

BACKGROUND: The objective of this retrospective cohort study was to investigate the burden of disability and death in men, from middle age to age of retirement, among occupational groups and classes in Geneva. METHODS: Men were included if they resided in the Canton of Geneva, were 45 years of age in 1970-1972, and were not receiving a disability pension at the start of the follow-up. The cohort of 5137 men was followed up for 20 years and linked to national registers of disability pension allowance and of causes of death. RESULTS: There was a steep upward trend in incidence of permanent work incapacity with lower social class for all causes as well as for the seven causes of disability studied. Compared with professional occupations (social class I), the relative risk (RR) of permanent work incapacity was 11.4 for partly skilled and unskilled occupations (class IV+V) (95% confidence interval [CI]: 5.2-28.0). The social class gradient in mortality was in the same direction as that in work incapacity although much less steep (RR class IV+V to class I = 1.6, 95% CI : 1.1-2.2). Survival without work incapacity at the time of the 65th birthday ranged from only 57% in construction workers and labourers to 89% in science and related professionals. Unemployment in Geneva was below 1.5% during almost all the study period. CONCLUSIONS: Medically-ascertained permanent work incapacity and survival without work incapacity have shown considerably greater socioeconomic differentials than the mortality differentials.  (+info)

(6/49462) A method for calculating age-weighted death proportions for comparison purposes.

OBJECTIVE: To introduce a method for calculating age-weighted death proportions (wDP) for comparison purposes. MATERIALS AND METHODS: A methodological study using secondary data from the municipality of Sao Paulo, Brazil (1980-1994) was carried out. First, deaths are weighted in terms of years of potential life lost before the age of 100 years. Then, in order to eliminate distortion of comparisons among proportions of years of potential life lost before the age of 100 years (pYPLL-100), the denominator is set to that of a standard age distribution of deaths for all causes. Conventional death proportions (DP), pYPLL-100, and wDP were calculated. RESULTS: Populations in which deaths from a particular cause occur at older ages exhibit lower wDP than those in which deaths occur at younger ages. The sum of all cause-specific wDP equals one only when the test population has exactly the same age distribution of deaths for all causes as that of the standard population. CONCLUSION: Age-weighted death proportions improve the information given by conventional DP, and are strongly recommended for comparison purposes.  (+info)

(7/49462) Comparison of active and cancer registry-based follow-up for breast cancer in a prospective cohort study.

The authors compared the relative effectiveness of two distinct follow-up designs in prospective cohort studies--the active approach, based on direct contact with study subjects, and the passive approach, based on record linkages with population-based cancer registries--utilizing available information from the New York University Women's Health Study (WHS) and the New York State Cancer Registry (NYSCR). The analyses were limited to breast cancer cases identified during the period 1985-1992, for which follow-up was considered reasonably complete by both the WHS and the NYSCR. Among 12,947 cohort members who reported a New York State address, 303 pathologically confirmed cases were identified through active follow-up and 284 through record linkage. Sixty-three percent of cancers were identified by both sources, 21% by the WHS only, and 16% by the NYSCR only. The agreement was appreciably better for invasive cancers. The percentage of cases identified only by the NYSCR was increased among subjects whose active follow-up was incomplete, as well as among nonwhites, obese patients, and parous patients. This suggests that relying on either type of follow-up alone may introduce certain biases in evaluating risk factors for breast cancer. Combining both approaches appears to be a better strategy in prospective cohort studies.  (+info)

(8/49462) Reliability of information on physical activity and other chronic disease risk factors among US women aged 40 years or older.

Data on chronic disease risk behaviors and related variables, including barriers to and attitudes toward physical activity, are lacking for women of some racial/ethnic groups. A test-retest study was conducted from July 1996 through June 1997 among US women (n = 199) aged 40 years or more who were white, black, American Indian/Alaska Native, or Hispanic. The sample was selected and interviews were conducted using a modified version of the methods of the Behavioral Risk Factor Surveillance System. For behavioral risk factors such as physical inactivity, smoking, and low fruit and vegetable consumption, group prevalences were generally similar between interviews 1 and 2. However, kappa values for selected physical activity variables ranged from 0.26 to 0.51 and tended to be lower for black women. Discordance was low for variables on cigarette smoking and exposure to environmental tobacco smoke (kappa = 0.64-0.92). Discordance was high (kappa = 0.33) for low consumption of fruits and vegetables. Additional variables for barriers to and access to exercise ranged widely across racial/ethnic groups and in terms of measures of agreement. These methods illustrate an efficient way to sample and assess the reliability of data collected from women of racial/ethnic minority groups.  (+info)

sensitivity and specifi

  • Values of sensitivity and specificity consistent with our results are similar to previous validation studies of mammography. (
  • Another study used 34 patients to test the sensitivity and specificity if the MELISA test, and concluded that it is not useful for diagnosis of contact allergy to the metals gold, palladium and nickel, since a large number of false-positive results will be obtained. (


  • I have the impression that a lot of papers I look at have results that are not reproducible. (
  • I plan to discuss how these ideas play into good reproducible science and how one should program to guarantee reproducibility. (
  • The config file is one of the key ingredients in making results reproducible. (
  • MAIN RESULTS: The SSH index was highly reproducible (kappa=0.8). (
  • Record linkage can be done entirely without the aid of a computer, but the primary reasons computers are often used for record linkage are to reduce or eliminate manual review and to make results more easily reproducible. (


  • In addition to image collection management, the system facilitates common biological workflows typical of biological images: imaging, experimental annotation, repeated analysis and presentation of images and results. (
  • Reproducibility of experimental results is central to the scientific method. (
  • CK enables reproducibility of experimental results via community involvement similar to Wikipedia and Physics. (


  • Its products are focused to offer quality and the reproducibility of laboratory results. (


  • 2 laboratories showed significant bias, 1 poor reproducibility. (
  • The mean HbA 1c determined by laboratories performing mass spectrometry (MS) was the same as the mean determined by laboratories using capillary electrophoresis (CE), but the reproducibility at laboratories using CE was better. (
  • As a condition for publication, Nature asked for the results to be replicated by independent laboratories. (


  • Some of the observations made from this study are that there were twice as many negative as positive interactions, negative interactions were more informative than positive interactions, and genes with more connections were more likely to result in lethality when disrupted. (


  • If your collected data cannot be automatically linked (probably via metadata) to the exact instrument configuration at the time of collection, then you do not really have a scientific result: you have something suggestive but not convincing. (
  • Such unique identifier also enhances the reproducibility, an essential feature of scientific work. (
  • Open research computation also addresses the problem of reproducibility of scientific results. (
  • Clinical study design aims to ensure the scientific validity and reproducibility of the results. (


  • however, published efforts to explicitly model the conditional dependencies among the comparison attributes have not resulted in an improvement in record linkage quality. (
  • Computer matching has the advantages of allowing central supervision of processing, better quality control, speed, consistency, and better reproducibility of results. (


  • A disadvantage of DCMs is that they are based on arbitrarily chosen analytical methods, with results in arbitrary units. (


  • National estimates of the use of cancer screening procedures are based primarily on self-reported results from the National Health Interview Survey (NHIS) 9 and the Behavior Risk Factor Surveillance System (BRFSS), 10 These estimates are well-known to be subject to biases such as social response bias and recall bias ( 1 , 2 ). (


  • Much has been written about Fleischmann and Pons, but I have not found if their problem was lack of reproducibility (so they found a plot that looked good and just focused on that) or if there was something darker at work. (
  • The researchers found that a high frequency of positive results was obtained among healthy subjects with or without dental amalgam, and concluded that the test cannot be used as an objective test for mercury allergy. (
  • In 1991, Benveniste found the French Academy of Sciences willing to publish his latest results, obtained under the supervision of Alfred Spira, a statistician, in its weekly Proceedings. (
  • A 2007 paper published in the journal Scientometrics found that the results from the Shanghai rankings could not be reproduced from raw data using the method described by Liu and Cheng. (


  • With the cooperation of Benveniste's own team, the group failed to replicate the original results, and subsequent investigations did not support Benveniste's findings either. (


  • Very early on, it was realized that BisQue has to go schema-less to support the needs of diverse biological experiments-each experiment and analysis results are unique and slightly different. (


  • But it may be hard to compare results between systems, unless some formal audit is done to ensure that comparable work is done. (


  • Results: A total of 105 IFCC-RM data sets were evaluated: 95 were approved, 5 were not, and for 5 no data were submitted. (
  • These results along with a recent meta-analysis ( 2 ) suggest that national survey data overestimate mammography screening usage and do not capture important racial/ethnic differences in use. (
  • The data and analysis provenance is maintained for reproducibility of results. (


  • WBA strives to ensure objectivity, falsifiability and reproducibility of results. (


  • SPEC will normally not accept publication of CPU2000 results using modified source code, unless such modifications are unavoidable for the target environment, are submitted to SPEC, are made available to all users of the suite, and are formally approved by a vote. (
  • A week after publication of the article, Nature sent a team of three investigators to Benveniste's lab to attempt to replicate his results under controlled conditions. (


  • Analysis results are stored within the database for further querying and processing. (
  • More importantly, there was also a need for maintaining the analysis provenance for reproducing image analysis results. (


  • Biologists were puzzled by Benveniste's results, as only molecules of water, and no molecules of the original antibody, remained in these high dilutions. (


  • A recently signed Consensus Statement by the American Diabetes Organization, European Association for the Study of Diabetes, International Diabetes Federation, and IFCC states that the IFCC-RM represents the only valid anchor to implement standardization and also that HbA1c results be represented worldwide in IFCC Units (mmol/mol) and derived NGSP units (%) using the IFCC-NGSP master equation ( 15 ). (
  • As a result, units of measure could vary not only from location to location, but from person to person. (


  • The resulting image can be detected directly by the eye, imaged on a photographic plate, or captured digitally. (


  • This approach, among other advantages, provides manageable control over accuracy and precision of the results. (


  • To report the results of the generation of items and domains of a scale to determine MQ in studies of DT and to determine interobserver reliability of this scale. (
  • Results: Self-report estimates of mammography use in the prior 2 years from the Vermont Behavioral Risk Factor Surveillance System are 15 to 25 percentage points higher than actual screening rates across age groups. (