The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Facilities equipped to carry out investigative procedures.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
Method of making images on a sensitized surface by exposure to light or other radiant energy.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Elements of limited time intervals, contributing to particular results or situations.
Products resulting from the conversion of one language to another.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Methods of creating machines and devices.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Computer systems or networks designed to provide radiographic interpretive information.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Timing the acquisition of imaging data to specific points in the breathing cycle to minimize image blurring and other motion artifacts. The images are used diagnostically and also interventionally to coordinate radiation treatment beam on/off cycles to protect healthy tissues when they move into the beam field during different times in the breathing cycle.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Reference points located by visual inspection, palpation, or computer assistance, that are useful in localizing structures on or within the human body.
Sequential operating programs and data which instruct the functioning of a digital computer.
Records of nutrient intake over a specific period of time, usually kept by the patient.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)
Controlled operations of analytic or diagnostic processes, or systems by mechanical or electronic devices.
Systematic collections of factual data pertaining to the diet of a human population within a given geographic area.
A series of steps taken in order to conduct research.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Substances used to allow enhanced visualization of tissues.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
A verbal or nonverbal means of communicating ideas or feelings.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.
Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.
Making measurements by the use of stereoscopic photographs.
Chromatographic techniques in which the mobile phase is a liquid.
Method of analyzing chemicals using automation.
Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.
Measurement of the thickness of the CORNEA.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
The measurement of the dimensions of the HEAD.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
Assessments aimed at determining agreement in diagnostic test results among laboratories. Identical survey samples are distributed to participating laboratories, with results stratified according to testing methodologies.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
An examination of chemicals in the blood.
A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
The upper part of the human body, or the front or upper part of the body of an animal, typically separated from the rest of the body by a neck, and containing the brain, mouth, and sense organs.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
A rapid, low-dose, digital imaging system using a small intraoral sensor instead of radiographic film, an intensifying screen, and a charge-coupled device. It presents the possibility of reduced patient exposure and minimal distortion, although resolution and latitude are inferior to standard dental radiography. A receiver is placed in the mouth, routing signals to a computer which images the signals on a screen or in print. It includes digitizing from x-ray film or any other detector. (From MEDLINE abstracts; personal communication from Dr. Charles Berthold, NIDR)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)
Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.
An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
The development and use of techniques and equipment to study or perform chemical reactions, with small quantities of materials, frequently less than a milligram or a milliliter.
Radiographic techniques used in dentistry.
Measurements of joint flexibility (RANGE OF MOTION, ARTICULAR), usually by employing an angle-measuring device (arthrometer). Arthrometry is used to measure ligamentous laxity and stability. It is often used to evaluate the outcome of ANTERIOR CRUCIATE LIGAMENT replacement surgery.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
The position or attitude of the body.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
Use of various chemical separation and extraction methods, such as SOLID PHASE EXTRACTION; CHROMATOGRAPHY; and SUPERCRITICAL FLUID EXTRACTION; to prepare samples for analytical measurement of components.
Methods for assessing flow through a system by injection of a known quantity of an indicator, such as a dye, radionuclide, or chilled liquid, into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
1976 accidental release of DIOXINS from a manufacturing facility in Seveso, ITALY following an equipment failure.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.
A computer in a medical context is an electronic device that processes, stores, and retrieves data, often used in medical settings for tasks such as maintaining patient records, managing diagnostic images, and supporting clinical decision-making through software applications and tools.
Measuring and weighing systems and processes.
An involuntary or voluntary pause in breathing, sometimes accompanied by loss of consciousness.
Descriptive anatomy based on three-dimensional imaging (IMAGING, THREE-DIMENSIONAL) of the body, organs, and structures using a series of computer multiplane sections, displayed by transverse, coronal, and sagittal analyses. It is essential to accurate interpretation by the radiologist of such techniques as ultrasonic diagnosis, MAGNETIC RESONANCE IMAGING, and computed tomography (TOMOGRAPHY, X-RAY COMPUTED). (From Lane & Sharfaei, Modern Sectional Anatomy, 1992, Preface)
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.
Techniques used in studying bacteria.
Recording of change in the size of a part as modified by the circulation in it.
A method of three-dimensional morphometry in which contour maps are produced from the overlapping interference fringes created when an object is illuminated by beams of coherent light issuing from two different point sources.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Measurement of distances or movements by means of the phenomena caused by the interference of two rays of light (optical interferometry) or of sound (acoustic interferometry).
The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.
Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)
Application of computer programs designed to assist the physician in solving a diagnostic problem.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A technetium diagnostic aid used in renal function determination.
Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
A nontoxic radiopharmaceutical that is used in the clinical evaluation of hepatobiliary disorders in humans.
Small computers using LSI (large-scale integration) microprocessor chips as the CPU (central processing unit) and semiconductor memories for compact, inexpensive storage of program instructions and data. They are smaller and less expensive than minicomputers and are usually built into a dedicated system where they are optimized for a particular application. "Microprocessor" may refer to just the CPU or the entire microcomputer.
Any tests done on exhaled air.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.
The act of testing the software for compliance with a standard.
Systematic and thorough inspection of the patient for physical signs of disease or abnormality.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Data processing largely performed by automatic means.
A facial expression which may denote feelings of pleasure, affection, amusement, etc.
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Use of optic and geometric techniques to enhance radiographic image quality and interpretation. It includes use of microfocal X-ray tubes and intensifying fluoroscopic screens.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Techniques for measuring blood pressure.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
Screens which absorb the energy in the x-ray beam that has penetrated the patient and convert this energy into a light pattern which has as nearly as possible the same information as the original x-ray beam. The more light a screen produces for a given input of x-radiation, the less x-ray exposure and thus shorter exposure time are needed to expose the film. In most film-screen systems, the film is sandwiched between two screens in a cassette so that the emulsion on each side is exposed to the light from its contiguous screen.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
Examination of the angle of the anterior chamber of the eye with a specialized optical instrument (gonioscope) or a contact prism lens.
The pressure of the fluids in the eye.
Tumors or cancer of the human BREAST.
Measurement of the various properties of light.
Regular course of eating and drinking adopted by a person or animal.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.
The protein complement of an organism coded for by its genome.
Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with little or no loss of their catalytic activity. Since they can be reused continuously, immobilized enzymes have found wide application in the industrial, medical and research fields.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Timing the acquisition of imaging data to specific points in the cardiac cycle to minimize image blurring and other motion artifacts.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Hand-held tools or implements especially used by dental professionals for the performance of clinical tasks.
Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.
I'm sorry for any confusion, but "Brazil" is not a medical term or concept, it is a country located in South America, known officially as the Federative Republic of Brazil. If you have any questions related to health, medicine, or science, I'd be happy to help answer those!
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
The branch of medicine dealing with the fetus and infant during the perinatal period. The perinatal period begins with the twenty-eighth week of gestation and ends twenty-eight days after birth. (From Dorland, 27th ed)
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.

Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label. (1/49462)

A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair.  (+info)

Urinary lithium: distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry. (2/49462)

Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples. The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans. Urine samples obtained from male workers (n = 86) who had not been exposed to lithium were used for the determination of this element by ICPAES. The obtained concentrations were corrected using a specific gravity of 1.024. The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread. Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 microg/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 microg/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure. Calibration curves obtained for lithium standards had good sensitivity and linearity. Good reproducibility was assessed by lithium addition to urine samples. It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk.  (+info)

Transient and permanent deficits in motion perception after lesions of cortical areas MT and MST in the macaque monkey. (3/49462)

We examined the nature and the selectivity of the motion deficits produced by lesions of extrastriate areas MT and MST. Lesions were made by injecting ibotenic acid into the representation of the left visual field in two macaque monkeys. The monkeys discriminated two stimuli that differed either in stimulus direction or orientation. Direction and orientation discrimination were assessed by measuring thresholds with gratings and random-dots placed in the intact or lesioned visual fields. At the start of behavioral testing, we found pronounced, motion-specific deficits in thresholds for all types of moving stimuli, including pronounced elevations in contrast thresholds and in signal-to-noise thresholds measured with moving gratings, as well as deficits in direction range thresholds and motion coherence measured with random-dot stimuli. In addition, the accuracy of direction discrimination was reduced at smaller spatial displacements (i.e. step sizes), suggesting an increase in spatial scale of the residual directional mechanism. Subsequent improvements in thresholds were seen with all motion stimuli, as behavioral training progressed, and these improvements occurred only with extensive behavioral testing in the lesioned visual field. These improvements were particularly pronounced for stimuli not masked by noise. On the other hand, deficits in the ability to extract motion from noisy stimuli and in the accuracy of direction discrimination persisted despite extensive behavioral training. These results demonstrate the importance of areas MT and MST for the perception of motion direction, particularly in the presence of noise. In addition, they provide evidence for the importance of behavioral training for functional recovery after cortical lesions. The data also strongly support the idea of functional specialization of areas MT and MST for motion processing.  (+info)

Comparative efficacy of positron emission tomography with FDG and computed tomographic scanning in preoperative staging of non-small cell lung cancer. (4/49462)

OBJECTIVE: To determine the sensitivity, specificity, and accuracy of positron emission tomography with 2-fluorine-18-fluorodeoxyglucose (PET-FDG) in the preoperative staging (N and M staging) of patients with lung cancer. The authors wanted to compare the efficacy of PET scanning with currently used computed tomography (CT) scanning. MATERIALS AND METHODS: Results of whole-body PET-FDG imaging and CT scans were compared with histologic findings for the presence or absence of lymph node disease or metastatic sites. Sampling of mediastinal lymph nodes was performed using mediastinoscopy or thoracotomy. RESULTS: PET-FDG imaging was significantly more sensitive, specific, and accurate for detecting N disease than CT. PET changed N staging in 35% and M staging in 11% of patients. CT scans helped in accurate anatomic localization of 6/57 PET lymph node abnormalities. CONCLUSION: PET-FDG is a reliable method for preoperative staging of patients with lung cancer and would help to optimize management of these patients. Accurate lymph node staging of lung cancer may be ideally performed by simultaneous review of PET and CT scans.  (+info)

Permanent work incapacity, mortality and survival without work incapacity among occupations and social classes: a cohort study of ageing men in Geneva. (5/49462)

BACKGROUND: The objective of this retrospective cohort study was to investigate the burden of disability and death in men, from middle age to age of retirement, among occupational groups and classes in Geneva. METHODS: Men were included if they resided in the Canton of Geneva, were 45 years of age in 1970-1972, and were not receiving a disability pension at the start of the follow-up. The cohort of 5137 men was followed up for 20 years and linked to national registers of disability pension allowance and of causes of death. RESULTS: There was a steep upward trend in incidence of permanent work incapacity with lower social class for all causes as well as for the seven causes of disability studied. Compared with professional occupations (social class I), the relative risk (RR) of permanent work incapacity was 11.4 for partly skilled and unskilled occupations (class IV+V) (95% confidence interval [CI]: 5.2-28.0). The social class gradient in mortality was in the same direction as that in work incapacity although much less steep (RR class IV+V to class I = 1.6, 95% CI : 1.1-2.2). Survival without work incapacity at the time of the 65th birthday ranged from only 57% in construction workers and labourers to 89% in science and related professionals. Unemployment in Geneva was below 1.5% during almost all the study period. CONCLUSIONS: Medically-ascertained permanent work incapacity and survival without work incapacity have shown considerably greater socioeconomic differentials than the mortality differentials.  (+info)

A method for calculating age-weighted death proportions for comparison purposes. (6/49462)

OBJECTIVE: To introduce a method for calculating age-weighted death proportions (wDP) for comparison purposes. MATERIALS AND METHODS: A methodological study using secondary data from the municipality of Sao Paulo, Brazil (1980-1994) was carried out. First, deaths are weighted in terms of years of potential life lost before the age of 100 years. Then, in order to eliminate distortion of comparisons among proportions of years of potential life lost before the age of 100 years (pYPLL-100), the denominator is set to that of a standard age distribution of deaths for all causes. Conventional death proportions (DP), pYPLL-100, and wDP were calculated. RESULTS: Populations in which deaths from a particular cause occur at older ages exhibit lower wDP than those in which deaths occur at younger ages. The sum of all cause-specific wDP equals one only when the test population has exactly the same age distribution of deaths for all causes as that of the standard population. CONCLUSION: Age-weighted death proportions improve the information given by conventional DP, and are strongly recommended for comparison purposes.  (+info)

Comparison of active and cancer registry-based follow-up for breast cancer in a prospective cohort study. (7/49462)

The authors compared the relative effectiveness of two distinct follow-up designs in prospective cohort studies--the active approach, based on direct contact with study subjects, and the passive approach, based on record linkages with population-based cancer registries--utilizing available information from the New York University Women's Health Study (WHS) and the New York State Cancer Registry (NYSCR). The analyses were limited to breast cancer cases identified during the period 1985-1992, for which follow-up was considered reasonably complete by both the WHS and the NYSCR. Among 12,947 cohort members who reported a New York State address, 303 pathologically confirmed cases were identified through active follow-up and 284 through record linkage. Sixty-three percent of cancers were identified by both sources, 21% by the WHS only, and 16% by the NYSCR only. The agreement was appreciably better for invasive cancers. The percentage of cases identified only by the NYSCR was increased among subjects whose active follow-up was incomplete, as well as among nonwhites, obese patients, and parous patients. This suggests that relying on either type of follow-up alone may introduce certain biases in evaluating risk factors for breast cancer. Combining both approaches appears to be a better strategy in prospective cohort studies.  (+info)

Reliability of information on physical activity and other chronic disease risk factors among US women aged 40 years or older. (8/49462)

Data on chronic disease risk behaviors and related variables, including barriers to and attitudes toward physical activity, are lacking for women of some racial/ethnic groups. A test-retest study was conducted from July 1996 through June 1997 among US women (n = 199) aged 40 years or more who were white, black, American Indian/Alaska Native, or Hispanic. The sample was selected and interviews were conducted using a modified version of the methods of the Behavioral Risk Factor Surveillance System. For behavioral risk factors such as physical inactivity, smoking, and low fruit and vegetable consumption, group prevalences were generally similar between interviews 1 and 2. However, kappa values for selected physical activity variables ranged from 0.26 to 0.51 and tended to be lower for black women. Discordance was low for variables on cigarette smoking and exposure to environmental tobacco smoke (kappa = 0.64-0.92). Discordance was high (kappa = 0.33) for low consumption of fruits and vegetables. Additional variables for barriers to and access to exercise ranged widely across racial/ethnic groups and in terms of measures of agreement. These methods illustrate an efficient way to sample and assess the reliability of data collected from women of racial/ethnic minority groups.  (+info)

Reproducibility of results in a medical context refers to the ability to obtain consistent and comparable findings when a particular experiment or study is repeated, either by the same researcher or by different researchers, following the same experimental protocol. It is an essential principle in scientific research that helps to ensure the validity and reliability of research findings.

In medical research, reproducibility of results is crucial for establishing the effectiveness and safety of new treatments, interventions, or diagnostic tools. It involves conducting well-designed studies with adequate sample sizes, appropriate statistical analyses, and transparent reporting of methods and findings to allow other researchers to replicate the study and confirm or refute the results.

The lack of reproducibility in medical research has become a significant concern in recent years, as several high-profile studies have failed to produce consistent findings when replicated by other researchers. This has led to increased scrutiny of research practices and a call for greater transparency, rigor, and standardization in the conduct and reporting of medical research.

Observer variation, also known as inter-observer variability or measurement agreement, refers to the difference in observations or measurements made by different observers or raters when evaluating the same subject or phenomenon. It is a common issue in various fields such as medicine, research, and quality control, where subjective assessments are involved.

In medical terms, observer variation can occur in various contexts, including:

1. Diagnostic tests: Different radiologists may interpret the same X-ray or MRI scan differently, leading to variations in diagnosis.
2. Clinical trials: Different researchers may have different interpretations of clinical outcomes or adverse events, affecting the consistency and reliability of trial results.
3. Medical records: Different healthcare providers may document medical histories, physical examinations, or treatment plans differently, leading to inconsistencies in patient care.
4. Pathology: Different pathologists may have varying interpretations of tissue samples or laboratory tests, affecting diagnostic accuracy.

Observer variation can be minimized through various methods, such as standardized assessment tools, training and calibration of observers, and statistical analysis of inter-rater reliability.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

Computer-assisted image processing is a medical term that refers to the use of computer systems and specialized software to improve, analyze, and interpret medical images obtained through various imaging techniques such as X-ray, CT (computed tomography), MRI (magnetic resonance imaging), ultrasound, and others.

The process typically involves several steps, including image acquisition, enhancement, segmentation, restoration, and analysis. Image processing algorithms can be used to enhance the quality of medical images by adjusting contrast, brightness, and sharpness, as well as removing noise and artifacts that may interfere with accurate diagnosis. Segmentation techniques can be used to isolate specific regions or structures of interest within an image, allowing for more detailed analysis.

Computer-assisted image processing has numerous applications in medical imaging, including detection and characterization of lesions, tumors, and other abnormalities; assessment of organ function and morphology; and guidance of interventional procedures such as biopsies and surgeries. By automating and standardizing image analysis tasks, computer-assisted image processing can help to improve diagnostic accuracy, efficiency, and consistency, while reducing the potential for human error.

Reference standards in a medical context refer to the established and widely accepted norms or benchmarks used to compare, evaluate, or measure the performance, accuracy, or effectiveness of diagnostic tests, treatments, or procedures. These standards are often based on extensive research, clinical trials, and expert consensus, and they help ensure that healthcare practices meet certain quality and safety thresholds.

For example, in laboratory medicine, reference standards may consist of well-characterized samples with known concentrations of analytes (such as chemicals or biological markers) that are used to calibrate instruments and validate testing methods. In clinical practice, reference standards may take the form of evidence-based guidelines or best practices that define appropriate care for specific conditions or patient populations.

By adhering to these reference standards, healthcare professionals can help minimize variability in test results, reduce errors, improve diagnostic accuracy, and ensure that patients receive consistent, high-quality care.

Three-dimensional (3D) imaging in medicine refers to the use of technologies and techniques that generate a 3D representation of internal body structures, organs, or tissues. This is achieved by acquiring and processing data from various imaging modalities such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, or confocal microscopy. The resulting 3D images offer a more detailed visualization of the anatomy and pathology compared to traditional 2D imaging techniques, allowing for improved diagnostic accuracy, surgical planning, and minimally invasive interventions.

In 3D imaging, specialized software is used to reconstruct the acquired data into a volumetric model, which can be manipulated and viewed from different angles and perspectives. This enables healthcare professionals to better understand complex anatomical relationships, detect abnormalities, assess disease progression, and monitor treatment response. Common applications of 3D imaging include neuroimaging, orthopedic surgery planning, cancer staging, dental and maxillofacial reconstruction, and interventional radiology procedures.

"Quality control" is a term that is used in many industries, including healthcare and medicine, to describe the systematic process of ensuring that products or services meet certain standards and regulations. In the context of healthcare, quality control often refers to the measures taken to ensure that the care provided to patients is safe, effective, and consistent. This can include processes such as:

1. Implementing standardized protocols and guidelines for care
2. Training and educating staff to follow these protocols
3. Regularly monitoring and evaluating the outcomes of care
4. Making improvements to processes and systems based on data and feedback
5. Ensuring that equipment and supplies are maintained and functioning properly
6. Implementing systems for reporting and addressing safety concerns or errors.

The goal of quality control in healthcare is to provide high-quality, patient-centered care that meets the needs and expectations of patients, while also protecting their safety and well-being.

A laboratory (often abbreviated as lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurements may be performed. In the medical field, laboratories are specialized spaces for conducting diagnostic tests and analyzing samples of bodily fluids, tissues, or other substances to gain insights into patients' health status.

There are various types of medical laboratories, including:

1. Clinical Laboratories: These labs perform tests on patient specimens to assist in the diagnosis, treatment, and prevention of diseases. They analyze blood, urine, stool, CSF (cerebrospinal fluid), and other samples for chemical components, cell counts, microorganisms, and genetic material.
2. Pathology Laboratories: These labs focus on the study of disease processes, causes, and effects. Histopathology involves examining tissue samples under a microscope to identify abnormalities or signs of diseases, while cytopathology deals with individual cells.
3. Microbiology Laboratories: In these labs, microorganisms like bacteria, viruses, fungi, and parasites are cultured, identified, and studied to help diagnose infections and determine appropriate treatments.
4. Molecular Biology Laboratories: These labs deal with the study of biological molecules, such as DNA, RNA, and proteins, to understand their structure, function, and interactions. They often use techniques like PCR (polymerase chain reaction) and gene sequencing for diagnostic purposes.
5. Immunology Laboratories: These labs specialize in the study of the immune system and its responses to various stimuli, including infectious agents and allergens. They perform tests to diagnose immunological disorders, monitor immune function, and assess vaccine effectiveness.
6. Toxicology Laboratories: These labs analyze biological samples for the presence and concentration of chemicals, drugs, or toxins that may be harmful to human health. They help identify potential causes of poisoning, drug interactions, and substance abuse.
7. Blood Banks: Although not traditionally considered laboratories, blood banks are specialized facilities that collect, test, store, and distribute blood and its components for transfusion purposes.

Medical laboratories play a crucial role in diagnosing diseases, monitoring disease progression, guiding treatment decisions, and assessing patient outcomes. They must adhere to strict quality control measures and regulatory guidelines to ensure accurate and reliable results.

Reference values, also known as reference ranges or reference intervals, are the set of values that are considered normal or typical for a particular population or group of people. These values are often used in laboratory tests to help interpret test results and determine whether a patient's value falls within the expected range.

The process of establishing reference values typically involves measuring a particular biomarker or parameter in a large, healthy population and then calculating the mean and standard deviation of the measurements. Based on these statistics, a range is established that includes a certain percentage of the population (often 95%) and excludes extreme outliers.

It's important to note that reference values can vary depending on factors such as age, sex, race, and other demographic characteristics. Therefore, it's essential to use reference values that are specific to the relevant population when interpreting laboratory test results. Additionally, reference values may change over time due to advances in measurement technology or changes in the population being studied.

Computer-assisted image interpretation is the use of computer algorithms and software to assist healthcare professionals in analyzing and interpreting medical images. These systems use various techniques such as pattern recognition, machine learning, and artificial intelligence to help identify and highlight abnormalities or patterns within imaging data, such as X-rays, CT scans, MRI, and ultrasound images. The goal is to increase the accuracy, consistency, and efficiency of image interpretation, while also reducing the potential for human error. It's important to note that these systems are intended to assist healthcare professionals in their decision making process and not to replace them.

Diagnostic techniques in ophthalmology refer to the various methods and tests used by eye specialists (ophthalmologists) to examine, evaluate, and diagnose conditions related to the eyes and visual system. Here are some commonly used diagnostic techniques:

1. Visual Acuity Testing: This is a basic test to measure the sharpness of a person's vision. It typically involves reading letters or numbers from an eye chart at a specific distance.
2. Refraction Test: This test helps determine the correct lens prescription for glasses or contact lenses by measuring how light is bent as it passes through the cornea and lens.
3. Slit Lamp Examination: A slit lamp is a microscope that allows an ophthalmologist to examine the structures of the eye, including the cornea, iris, lens, and retina, in great detail.
4. Tonometry: This test measures the pressure inside the eye (intraocular pressure) to detect conditions like glaucoma. Common methods include applanation tonometry and non-contact tonometry.
5. Retinal Imaging: Several techniques are used to capture images of the retina, including fundus photography, fluorescein angiography, and optical coherence tomography (OCT). These tests help diagnose conditions like macular degeneration, diabetic retinopathy, and retinal detachments.
6. Color Vision Testing: This test evaluates a person's ability to distinguish between different colors, which can help detect color vision deficiencies or neurological disorders affecting the visual pathway.
7. Visual Field Testing: This test measures a person's peripheral (or side) vision and can help diagnose conditions like glaucoma, optic nerve damage, or brain injuries.
8. Pupillary Reactions Tests: These tests evaluate how the pupils respond to light and near objects, which can provide information about the condition of the eye's internal structures and the nervous system.
9. Ocular Motility Testing: This test assesses eye movements and alignment, helping diagnose conditions like strabismus (crossed eyes) or nystagmus (involuntary eye movement).
10. Corneal Topography: This non-invasive imaging technique maps the curvature of the cornea, which can help detect irregularities, assess the fit of contact lenses, and plan refractive surgery procedures.

"Evaluation studies" is a broad term that refers to the systematic assessment or examination of a program, project, policy, intervention, or product. The goal of an evaluation study is to determine its merits, worth, and value by measuring its effects, efficiency, and impact. There are different types of evaluation studies, including formative evaluations (conducted during the development or implementation of a program to provide feedback for improvement), summative evaluations (conducted at the end of a program to determine its overall effectiveness), process evaluations (focusing on how a program is implemented and delivered), outcome evaluations (assessing the short-term and intermediate effects of a program), and impact evaluations (measuring the long-term and broad consequences of a program).

In medical contexts, evaluation studies are often used to assess the safety, efficacy, and cost-effectiveness of new treatments, interventions, or technologies. These studies can help healthcare providers make informed decisions about patient care, guide policymakers in developing evidence-based policies, and promote accountability and transparency in healthcare systems. Examples of evaluation studies in medicine include randomized controlled trials (RCTs) that compare the outcomes of a new treatment to those of a standard or placebo treatment, observational studies that examine the real-world effectiveness and safety of interventions, and economic evaluations that assess the costs and benefits of different healthcare options.

In the context of medicine and medical devices, calibration refers to the process of checking, adjusting, or confirming the accuracy of a measurement instrument or system. This is typically done by comparing the measurements taken by the device being calibrated to those taken by a reference standard of known accuracy. The goal of calibration is to ensure that the medical device is providing accurate and reliable measurements, which is critical for making proper diagnoses and delivering effective treatment. Regular calibration is an important part of quality assurance and helps to maintain the overall performance and safety of medical devices.

Automation in the medical context refers to the use of technology and programming to allow machines or devices to operate with minimal human intervention. This can include various types of medical equipment, such as laboratory analyzers, imaging devices, and robotic surgical systems. Automation can help improve efficiency, accuracy, and safety in healthcare settings by reducing the potential for human error and allowing healthcare professionals to focus on higher-level tasks. It is important to note that while automation has many benefits, it is also essential to ensure that appropriate safeguards are in place to prevent accidents and maintain quality of care.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

An algorithm is not a medical term, but rather a concept from computer science and mathematics. In the context of medicine, algorithms are often used to describe step-by-step procedures for diagnosing or managing medical conditions. These procedures typically involve a series of rules or decision points that help healthcare professionals make informed decisions about patient care.

For example, an algorithm for diagnosing a particular type of heart disease might involve taking a patient's medical history, performing a physical exam, ordering certain diagnostic tests, and interpreting the results in a specific way. By following this algorithm, healthcare professionals can ensure that they are using a consistent and evidence-based approach to making a diagnosis.

Algorithms can also be used to guide treatment decisions. For instance, an algorithm for managing diabetes might involve setting target blood sugar levels, recommending certain medications or lifestyle changes based on the patient's individual needs, and monitoring the patient's response to treatment over time.

Overall, algorithms are valuable tools in medicine because they help standardize clinical decision-making and ensure that patients receive high-quality care based on the latest scientific evidence.

Optical coherence tomography (OCT) is a non-invasive imaging technique that uses low-coherence light to capture high-resolution cross-sectional images of biological tissues, particularly the retina and other ocular structures. OCT works by measuring the echo time delay of light scattered back from different depths within the tissue, creating a detailed map of the tissue's structure. This technique is widely used in ophthalmology to diagnose and monitor various eye conditions such as macular degeneration, diabetic retinopathy, and glaucoma.

Image enhancement in the medical context refers to the process of improving the quality and clarity of medical images, such as X-rays, CT scans, MRI scans, or ultrasound images, to aid in the diagnosis and treatment of medical conditions. Image enhancement techniques may include adjusting contrast, brightness, or sharpness; removing noise or artifacts; or applying specialized algorithms to highlight specific features or structures within the image.

The goal of image enhancement is to provide clinicians with more accurate and detailed information about a patient's anatomy or physiology, which can help inform medical decision-making and improve patient outcomes.

I'm sorry for any confusion, but "photography" is not a term typically used in medical definitions. Photography refers to the art, application, or process of creating images by recording light or other electromagnetic radiation, either electronically by means of an image sensor, or chemically by means of a light-sensitive material such as photographic film.

If you're looking for a medical term related to imaging, there are several terms that might be relevant, such as:

1. Radiography: This is a technique using X-rays to visualize the internal structures of the body.
2. Ultrasonography: Also known as ultrasound, this is a diagnostic imaging technique using high-frequency sound waves to create images of the inside of the body.
3. Computed Tomography (CT): A type of imaging that uses X-rays to create detailed cross-sectional images of the body.
4. Magnetic Resonance Imaging (MRI): A type of imaging that uses magnetic fields and radio waves to create detailed images of the organs and tissues within the body.
5. Nuclear Medicine: This is a branch of medical imaging that uses small amounts of radioactive material to diagnose and treat diseases.

If you have any questions related to medical definitions or topics, feel free to ask!

Reagent kits, diagnostic are prepackaged sets of chemical reagents and other components designed for performing specific diagnostic tests or assays. These kits are often used in clinical laboratories to detect and measure the presence or absence of various biomarkers, such as proteins, antibodies, antigens, nucleic acids, or small molecules, in biological samples like blood, urine, or tissues.

Diagnostic reagent kits typically contain detailed instructions for their use, along with the necessary reagents, controls, and sometimes specialized equipment or supplies. They are designed to simplify the testing process, reduce human error, and increase standardization, ensuring accurate and reliable results. Examples of diagnostic reagent kits include those used for pregnancy tests, infectious disease screening, drug testing, genetic testing, and cancer biomarker detection.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

I believe there may be some confusion in your question as "translations" is not a term that has a specific medical definition. However, if you are referring to the process of "translation" in the context of medicine and biomedical research, it refers to the process of converting scientific findings or medical information from one language to another, while maintaining accuracy, clarity, and the original meaning. This is particularly important in the field of international clinical trials, medical publications, and cross-cultural healthcare communication.

If you meant something different by 'translations', please provide more context so I can give a more accurate response.

Analysis of Variance (ANOVA) is a statistical technique used to compare the means of two or more groups and determine whether there are any significant differences between them. It is a way to analyze the variance in a dataset to determine whether the variability between groups is greater than the variability within groups, which can indicate that the groups are significantly different from one another.

ANOVA is based on the concept of partitioning the total variance in a dataset into two components: variance due to differences between group means (also known as "between-group variance") and variance due to differences within each group (also known as "within-group variance"). By comparing these two sources of variance, ANOVA can help researchers determine whether any observed differences between groups are statistically significant, or whether they could have occurred by chance.

ANOVA is a widely used technique in many areas of research, including biology, psychology, engineering, and business. It is often used to compare the means of two or more experimental groups, such as a treatment group and a control group, to determine whether the treatment had a significant effect. ANOVA can also be used to compare the means of different populations or subgroups within a population, to identify any differences that may exist between them.

Equipment design, in the medical context, refers to the process of creating and developing medical equipment and devices, such as surgical instruments, diagnostic machines, or assistive technologies. This process involves several stages, including:

1. Identifying user needs and requirements
2. Concept development and brainstorming
3. Prototyping and testing
4. Design for manufacturing and assembly
5. Safety and regulatory compliance
6. Verification and validation
7. Training and support

The goal of equipment design is to create safe, effective, and efficient medical devices that meet the needs of healthcare providers and patients while complying with relevant regulations and standards. The design process typically involves a multidisciplinary team of engineers, clinicians, designers, and researchers who work together to develop innovative solutions that improve patient care and outcomes.

The Predictive Value of Tests, specifically the Positive Predictive Value (PPV) and Negative Predictive Value (NPV), are measures used in diagnostic tests to determine the probability that a positive or negative test result is correct.

Positive Predictive Value (PPV) is the proportion of patients with a positive test result who actually have the disease. It is calculated as the number of true positives divided by the total number of positive results (true positives + false positives). A higher PPV indicates that a positive test result is more likely to be a true positive, and therefore the disease is more likely to be present.

Negative Predictive Value (NPV) is the proportion of patients with a negative test result who do not have the disease. It is calculated as the number of true negatives divided by the total number of negative results (true negatives + false negatives). A higher NPV indicates that a negative test result is more likely to be a true negative, and therefore the disease is less likely to be present.

The predictive value of tests depends on the prevalence of the disease in the population being tested, as well as the sensitivity and specificity of the test. A test with high sensitivity and specificity will generally have higher predictive values than a test with low sensitivity and specificity. However, even a highly sensitive and specific test can have low predictive values if the prevalence of the disease is low in the population being tested.

Computer-assisted radiographic image interpretation is the use of computer algorithms and software to assist and enhance the interpretation and analysis of medical images produced by radiography, such as X-rays, CT scans, and MRI scans. The computer-assisted system can help identify and highlight certain features or anomalies in the image, such as tumors, fractures, or other abnormalities, which may be difficult for the human eye to detect. This technology can improve the accuracy and speed of diagnosis, and may also reduce the risk of human error. It's important to note that the final interpretation and diagnosis is always made by a qualified healthcare professional, such as a radiologist, who takes into account the computer-assisted analysis in conjunction with their clinical expertise and knowledge.

Blood flow velocity is the speed at which blood travels through a specific part of the vascular system. It is typically measured in units of distance per time, such as centimeters per second (cm/s) or meters per second (m/s). Blood flow velocity can be affected by various factors, including cardiac output, vessel diameter, and viscosity of the blood. Measuring blood flow velocity is important in diagnosing and monitoring various medical conditions, such as heart disease, stroke, and peripheral vascular disease.

Respiratory-gated imaging techniques are medical imaging procedures that synchronize the data acquisition with the patient's respiratory cycle, in order to reduce motion artifacts and improve image quality. These techniques are often used in CT (computed tomography) and MR (magnetic resonance) imaging for thoracic and abdominal examinations, where respiratory motion can degrade the images and compromise diagnostic accuracy.

In a respiratory-gated imaging technique, the patient's breathing pattern is monitored using sensors such as pressure belts or navigators, which detect the movement of the diaphragm or chest wall. The imaging data are then acquired only during specific phases of the respiratory cycle, typically during the end-expiration phase when motion is minimal. This allows for the creation of sharp and detailed images that accurately represent the anatomy and pathology of interest.

Respiratory gating can be particularly useful in imaging patients with lung cancer, liver tumors, or other conditions that involve moving structures in the chest and abdomen. By reducing motion artifacts, these techniques can help ensure more accurate diagnosis, staging, and treatment planning.

A feasibility study is a preliminary investigation or analysis conducted to determine the viability of a proposed project, program, or product. In the medical field, feasibility studies are often conducted before implementing new treatments, procedures, equipment, or facilities. These studies help to assess the practicality and effectiveness of the proposed intervention, as well as its potential benefits and risks.

Feasibility studies in healthcare typically involve several steps:

1. Problem identification: Clearly define the problem that the proposed project, program, or product aims to address.
2. Objectives setting: Establish specific, measurable, achievable, relevant, and time-bound (SMART) objectives for the study.
3. Literature review: Conduct a thorough review of existing research and best practices related to the proposed intervention.
4. Methodology development: Design a methodology for data collection and analysis that will help answer the research questions and achieve the study's objectives.
5. Resource assessment: Evaluate the availability and adequacy of resources, including personnel, time, and finances, required to carry out the proposed intervention.
6. Risk assessment: Identify potential risks and challenges associated with the implementation of the proposed intervention and develop strategies to mitigate them.
7. Cost-benefit analysis: Estimate the costs and benefits of the proposed intervention, including direct and indirect costs, as well as short-term and long-term benefits.
8. Stakeholder engagement: Engage relevant stakeholders, such as patients, healthcare providers, administrators, and policymakers, to gather their input and support for the proposed intervention.
9. Decision-making: Based on the findings of the feasibility study, make an informed decision about whether or not to proceed with the proposed project, program, or product.

Feasibility studies are essential in healthcare as they help ensure that resources are allocated efficiently and effectively, and that interventions are evidence-based, safe, and beneficial for patients.

In the field of medical imaging, "phantoms" refer to physical objects that are specially designed and used for calibration, quality control, and evaluation of imaging systems. These phantoms contain materials with known properties, such as attenuation coefficients or spatial resolution, which allow for standardized measurement and comparison of imaging parameters across different machines and settings.

Imaging phantoms can take various forms depending on the modality of imaging. For example, in computed tomography (CT), a common type of phantom is the "water-equivalent phantom," which contains materials with similar X-ray attenuation properties as water. This allows for consistent measurement of CT dose and image quality. In magnetic resonance imaging (MRI), phantoms may contain materials with specific relaxation times or magnetic susceptibilities, enabling assessment of signal-to-noise ratio, spatial resolution, and other imaging parameters.

By using these standardized objects, healthcare professionals can ensure the accuracy, consistency, and reliability of medical images, ultimately contributing to improved patient care and safety.

Anatomic landmarks are specific, identifiable structures or features on the body that are used as references in medicine and surgery. These landmarks can include bones, muscles, joints, or other visible or palpable features that help healthcare professionals identify specific locations, orient themselves during procedures, or measure changes in the body.

Examples of anatomic landmarks include:

* The anterior iliac spine, a bony prominence on the front of the pelvis that can be used to locate the hip joint.
* The cubital fossa, a depression at the elbow where the median nerve and brachial artery can be palpated.
* The navel (umbilicus), which serves as a reference point for measuring distances in the abdomen.
* The xiphoid process, a small piece of cartilage at the bottom of the breastbone that can be used to locate the heart and other structures in the chest.

Anatomic landmarks are important for accurate diagnosis, treatment planning, and surgical procedures, as they provide reliable and consistent reference points that can help ensure safe and effective care.

I am not aware of a widely accepted medical definition for the term "software," as it is more commonly used in the context of computer science and technology. Software refers to programs, data, and instructions that are used by computers to perform various tasks. It does not have direct relevance to medical fields such as anatomy, physiology, or clinical practice. If you have any questions related to medicine or healthcare, I would be happy to try to help with those instead!

Diet records are documents used to track and record an individual's food and beverage intake over a specific period. These records may include details such as the type and quantity of food consumed, time of consumption, and any related observations or notes. Diet records can be used for various purposes, including assessing dietary habits and patterns, identifying potential nutritional deficiencies or excesses, and developing personalized nutrition plans. They are often used in research, clinical settings, and weight management programs.

Oligonucleotide Array Sequence Analysis is a type of microarray analysis that allows for the simultaneous measurement of the expression levels of thousands of genes in a single sample. In this technique, oligonucleotides (short DNA sequences) are attached to a solid support, such as a glass slide, in a specific pattern. These oligonucleotides are designed to be complementary to specific target mRNA sequences from the sample being analyzed.

During the analysis, labeled RNA or cDNA from the sample is hybridized to the oligonucleotide array. The level of hybridization is then measured and used to determine the relative abundance of each target sequence in the sample. This information can be used to identify differences in gene expression between samples, which can help researchers understand the underlying biological processes involved in various diseases or developmental stages.

It's important to note that this technique requires specialized equipment and bioinformatics tools for data analysis, as well as careful experimental design and validation to ensure accurate and reproducible results.

A questionnaire in the medical context is a standardized, systematic, and structured tool used to gather information from individuals regarding their symptoms, medical history, lifestyle, or other health-related factors. It typically consists of a series of written questions that can be either self-administered or administered by an interviewer. Questionnaires are widely used in various areas of healthcare, including clinical research, epidemiological studies, patient care, and health services evaluation to collect data that can inform diagnosis, treatment planning, and population health management. They provide a consistent and organized method for obtaining information from large groups or individual patients, helping to ensure accurate and comprehensive data collection while minimizing bias and variability in the information gathered.

Specimen handling is a set of procedures and practices followed in the collection, storage, transportation, and processing of medical samples or specimens (e.g., blood, tissue, urine, etc.) for laboratory analysis. Proper specimen handling ensures accurate test results, patient safety, and data integrity. It includes:

1. Correct labeling of the specimen container with required patient information.
2. Using appropriate containers and materials to collect, store, and transport the specimen.
3. Following proper collection techniques to avoid contamination or damage to the specimen.
4. Adhering to specific storage conditions (temperature, time, etc.) before testing.
5. Ensuring secure and timely transportation of the specimen to the laboratory.
6. Properly documenting all steps in the handling process for traceability and quality assurance.

Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.

Capillary electrophoresis (CE) is a laboratory technique used to separate and analyze charged particles such as proteins, nucleic acids, and other molecules based on their size and charge. In CE, the sample is introduced into a narrow capillary tube filled with a buffer solution, and an electric field is applied. The charged particles in the sample migrate through the capillary towards the electrode with the opposite charge, and the different particles become separated as they migrate based on their size and charge.

The separation process in CE is monitored by detecting the changes in the optical properties of the particles as they pass through a detector, typically located at the end of the capillary. The resulting data can be used to identify and quantify the individual components in the sample. Capillary electrophoresis has many applications in research and clinical settings, including the analysis of DNA fragments, protein identification and characterization, and the detection of genetic variations.

Automation in a laboratory refers to the use of technology and machinery to automatically perform tasks that were previously done manually by lab technicians or scientists. This can include tasks such as mixing and dispensing liquids, tracking and monitoring experiments, and analyzing samples. Automation can help increase efficiency, reduce human error, and allow lab personnel to focus on more complex tasks.

There are various types of automation systems used in laboratory settings, including:

1. Liquid handling systems: These machines automatically dispense precise volumes of liquids into containers or well plates, reducing the potential for human error and increasing throughput.
2. Robotic systems: Robots can be programmed to perform a variety of tasks, such as pipetting, centrifugation, and incubation, freeing up lab personnel for other duties.
3. Tracking and monitoring systems: These systems automatically track and monitor experiments, allowing scientists to remotely monitor their progress and receive alerts when an experiment is complete or if there are any issues.
4. Analysis systems: Automated analysis systems can quickly and accurately analyze samples, such as by measuring the concentration of a particular molecule or identifying specific genetic sequences.

Overall, automation in the laboratory can help improve accuracy, increase efficiency, and reduce costs, making it an essential tool for many scientific research and diagnostic applications.

A diet survey is a questionnaire or interview designed to gather information about an individual's eating habits and patterns. It typically includes questions about the types and quantities of foods and beverages consumed, meal frequency and timing, and any dietary restrictions or preferences. The purpose of a diet survey is to assess an individual's nutritional intake and identify areas for improvement or intervention in order to promote health and prevent or manage chronic diseases. Diet surveys may also be used in research settings to gather data on the eating habits of larger populations.

In the context of medical research, "methods" refers to the specific procedures or techniques used in conducting a study or experiment. This includes details on how data was collected, what measurements were taken, and what statistical analyses were performed. The methods section of a medical paper allows other researchers to replicate the study if they choose to do so. It is considered one of the key components of a well-written research article, as it provides transparency and helps establish the validity of the findings.

X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.

The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.

CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.

In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.

CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.

In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.

Gene expression profiling is a laboratory technique used to measure the activity (expression) of thousands of genes at once. This technique allows researchers and clinicians to identify which genes are turned on or off in a particular cell, tissue, or organism under specific conditions, such as during health, disease, development, or in response to various treatments.

The process typically involves isolating RNA from the cells or tissues of interest, converting it into complementary DNA (cDNA), and then using microarray or high-throughput sequencing technologies to determine which genes are expressed and at what levels. The resulting data can be used to identify patterns of gene expression that are associated with specific biological states or processes, providing valuable insights into the underlying molecular mechanisms of diseases and potential targets for therapeutic intervention.

In recent years, gene expression profiling has become an essential tool in various fields, including cancer research, drug discovery, and personalized medicine, where it is used to identify biomarkers of disease, predict patient outcomes, and guide treatment decisions.

High-performance liquid chromatography (HPLC) is a type of chromatography that separates and analyzes compounds based on their interactions with a stationary phase and a mobile phase under high pressure. The mobile phase, which can be a gas or liquid, carries the sample mixture through a column containing the stationary phase.

In HPLC, the mobile phase is a liquid, and it is pumped through the column at high pressures (up to several hundred atmospheres) to achieve faster separation times and better resolution than other types of liquid chromatography. The stationary phase can be a solid or a liquid supported on a solid, and it interacts differently with each component in the sample mixture, causing them to separate as they travel through the column.

HPLC is widely used in analytical chemistry, pharmaceuticals, biotechnology, and other fields to separate, identify, and quantify compounds present in complex mixtures. It can be used to analyze a wide range of substances, including drugs, hormones, vitamins, pigments, flavors, and pollutants. HPLC is also used in the preparation of pure samples for further study or use.

Contrast media are substances that are administered to a patient in order to improve the visibility of internal body structures or processes in medical imaging techniques such as X-rays, CT scans, MRI scans, and ultrasounds. These media can be introduced into the body through various routes, including oral, rectal, or intravenous administration.

Contrast media work by altering the appearance of bodily structures in imaging studies. For example, when a patient undergoes an X-ray examination, contrast media can be used to highlight specific organs, tissues, or blood vessels, making them more visible on the resulting images. In CT and MRI scans, contrast media can help to enhance the differences between normal and abnormal tissues, allowing for more accurate diagnosis and treatment planning.

There are several types of contrast media available, each with its own specific properties and uses. Some common examples include barium sulfate, which is used as a contrast medium in X-ray studies of the gastrointestinal tract, and iodinated contrast media, which are commonly used in CT scans to highlight blood vessels and other structures.

While contrast media are generally considered safe, they can sometimes cause adverse reactions, ranging from mild symptoms such as nausea or hives to more serious complications such as anaphylaxis or kidney damage. As a result, it is important for healthcare providers to carefully evaluate each patient's medical history and individual risk factors before administering contrast media.

Nerve fibers are specialized structures that constitute the long, slender processes (axons) of neurons (nerve cells). They are responsible for conducting electrical impulses, known as action potentials, away from the cell body and transmitting them to other neurons or effector organs such as muscles and glands. Nerve fibers are often surrounded by supportive cells called glial cells and are grouped together to form nerve bundles or nerves. These fibers can be myelinated (covered with a fatty insulating sheath called myelin) or unmyelinated, which influences the speed of impulse transmission.

Clinical pathology is a medical specialty that focuses on the diagnosis of diseases through the examination of organs, tissues, and bodily fluids, such as blood and urine. It involves the use of laboratory tests to identify abnormalities in the body's cells, chemicals, and functions that may indicate the presence of a specific disease or condition. Clinical pathologists work closely with other healthcare professionals to help manage patient care, provide treatment recommendations, and monitor the effectiveness of treatments. They are responsible for supervising the laboratory testing process, ensuring accurate results, and interpreting the findings in the context of each patient's medical history and symptoms. Overall, clinical pathology plays a critical role in the diagnosis, treatment, and prevention of many different types of diseases and conditions.

In the context of medicine, particularly in neurolinguistics and speech-language pathology, language is defined as a complex system of communication that involves the use of symbols (such as words, signs, or gestures) to express and exchange information. It includes various components such as phonology (sound systems), morphology (word structures), syntax (sentence structure), semantics (meaning), and pragmatics (social rules of use). Language allows individuals to convey their thoughts, feelings, and intentions, and to understand the communication of others. Disorders of language can result from damage to specific areas of the brain, leading to impairments in comprehension, production, or both.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

Clinical laboratory techniques are methods and procedures used in medical laboratories to perform various tests and examinations on patient samples. These techniques help in the diagnosis, treatment, and prevention of diseases by analyzing body fluids, tissues, and other specimens. Some common clinical laboratory techniques include:

1. Clinical chemistry: It involves the analysis of bodily fluids such as blood, urine, and cerebrospinal fluid to measure the levels of chemicals, hormones, enzymes, and other substances in the body. These measurements can help diagnose various medical conditions, monitor treatment progress, and assess overall health.

2. Hematology: This technique focuses on the study of blood and its components, including red and white blood cells, platelets, and clotting factors. Hematological tests are used to diagnose anemia, infections, bleeding disorders, and other hematologic conditions.

3. Microbiology: It deals with the identification and culture of microorganisms such as bacteria, viruses, fungi, and parasites. Microbiological techniques are essential for detecting infectious diseases, determining appropriate antibiotic therapy, and monitoring the effectiveness of treatment.

4. Immunology: This technique involves studying the immune system and its response to various antigens, such as bacteria, viruses, and allergens. Immunological tests are used to diagnose autoimmune disorders, immunodeficiencies, and allergies.

5. Histopathology: It is the microscopic examination of tissue samples to identify any abnormalities or diseases. Histopathological techniques are crucial for diagnosing cancer, inflammatory conditions, and other tissue-related disorders.

6. Molecular biology: This technique deals with the study of DNA, RNA, and proteins at the molecular level. Molecular biology tests can be used to detect genetic mutations, identify infectious agents, and monitor disease progression.

7. Cytogenetics: It involves analyzing chromosomes and genes in cells to diagnose genetic disorders, cancer, and other diseases. Cytogenetic techniques include karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH).

8. Flow cytometry: This technique measures physical and chemical characteristics of cells or particles as they flow through a laser beam. Flow cytometry is used to analyze cell populations, identify specific cell types, and detect abnormalities in cells.

9. Diagnostic radiology: It uses imaging technologies such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound to diagnose various medical conditions.

10. Clinical chemistry: This technique involves analyzing body fluids, such as blood and urine, to measure the concentration of various chemicals and substances. Clinical chemistry tests are used to diagnose metabolic disorders, electrolyte imbalances, and other health conditions.

Glaucoma is a group of eye conditions that damage the optic nerve, often caused by an abnormally high pressure in the eye (intraocular pressure). This damage can lead to permanent vision loss or even blindness if left untreated. The most common type is open-angle glaucoma, which has no warning signs and progresses slowly. Angle-closure glaucoma, on the other hand, can cause sudden eye pain, redness, nausea, and vomiting, as well as rapid vision loss. Other less common types of glaucoma also exist. While there is no cure for glaucoma, early detection and treatment can help slow or prevent further vision loss.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

The optic disk, also known as the optic nerve head, is the point where the optic nerve fibers exit the eye and transmit visual information to the brain. It appears as a pale, circular area in the back of the eye, near the center of the retina. The optic disk has no photoreceptor cells (rods and cones), so it is insensitive to light. It is an important structure to observe during eye examinations because changes in its appearance can indicate various ocular diseases or conditions, such as glaucoma, optic neuritis, or papilledema.

The 'Limit of Detection' (LOD) is a term used in laboratory medicine and clinical chemistry to describe the lowest concentration or quantity of an analyte (the substance being measured) that can be reliably distinguished from zero or blank value, with a specified level of confidence. It is typically expressed as a concentration or amount and represents the minimum amount of analyte that must be present in a sample for the assay to produce a response that is statistically different from a blank or zero calibrator.

The LOD is an important parameter in analytical method validation, as it helps to define the range of concentrations over which the assay can accurately and precisely measure the analyte. It is determined based on statistical analysis of the data generated during method development and validation, taking into account factors such as the variability of the assay and the signal-to-noise ratio.

It's important to note that LOD should not be confused with the 'Limit of Quantification' (LOQ), which is the lowest concentration or quantity of an analyte that can be measured with acceptable precision and accuracy. LOQ is typically higher than LOD, as it requires a greater level of confidence in the measurement.

Photogrammetry is not typically considered a medical term, but rather it is a technique used in various fields including engineering, architecture, and geology. However, it has found some applications in the medical field, particularly in orthopedics and wound care. Here's a definition that covers its general use as well as its medical applications:

Photogrammetry is the science of making measurements from photographs, especially for recovering the exact positions of surface points on an object. It involves the use of photography to accurately measure and map three-dimensional objects or environments. In the medical field, photogrammetry can be used to create 3D models of body parts (such as bones or wounds) by capturing multiple images from different angles and then processing them using specialized software. These 3D models can help healthcare professionals plan treatments, monitor progress, and assess outcomes in a more precise manner.

Liquid chromatography (LC) is a type of chromatography technique used to separate, identify, and quantify the components in a mixture. In this method, the sample mixture is dissolved in a liquid solvent (the mobile phase) and then passed through a stationary phase, which can be a solid or a liquid that is held in place by a solid support.

The components of the mixture interact differently with the stationary phase and the mobile phase, causing them to separate as they move through the system. The separated components are then detected and measured using various detection techniques, such as ultraviolet (UV) absorbance or mass spectrometry.

Liquid chromatography is widely used in many areas of science and medicine, including drug development, environmental analysis, food safety testing, and clinical diagnostics. It can be used to separate and analyze a wide range of compounds, from small molecules like drugs and metabolites to large biomolecules like proteins and nucleic acids.

"Autoanalysis" is not a term that is widely used in the medical field. However, in psychology and psychotherapy, "autoanalysis" refers to the process of self-analysis or self-examination, where an individual analyzes their own thoughts, feelings, behaviors, and experiences to gain insight into their unconscious mind and understand their motivations, conflicts, and emotional patterns.

Self-analysis can involve various techniques such as introspection, journaling, meditation, dream analysis, and reflection on past experiences. While autoanalysis can be a useful tool for personal growth and self-awareness, it is generally considered less reliable and comprehensive than professional psychotherapy or psychoanalysis, which involves a trained therapist or analyst who can provide objective feedback, interpretation, and guidance.

Tomography is a medical imaging technique used to produce cross-sectional images or slices of specific areas of the body. This technique uses various forms of radiation (X-rays, gamma rays) or sound waves (ultrasound) to create detailed images of the internal structures, such as organs, bones, and tissues. Common types of tomography include Computerized Tomography (CT), Positron Emission Tomography (PET), and Magnetic Resonance Imaging (MRI). The primary advantage of tomography is its ability to provide clear and detailed images of internal structures, allowing healthcare professionals to accurately diagnose and monitor a wide range of medical conditions.

Radiopharmaceuticals are defined as pharmaceutical preparations that contain radioactive isotopes and are used for diagnosis or therapy in nuclear medicine. These compounds are designed to interact specifically with certain biological targets, such as cells, tissues, or organs, and emit radiation that can be detected and measured to provide diagnostic information or used to destroy abnormal cells or tissue in therapeutic applications.

The radioactive isotopes used in radiopharmaceuticals have carefully controlled half-lives, which determine how long they remain radioactive and how long the pharmaceutical preparation remains effective. The choice of radioisotope depends on the intended use of the radiopharmaceutical, as well as factors such as its energy, range of emission, and chemical properties.

Radiopharmaceuticals are used in a wide range of medical applications, including imaging, cancer therapy, and treatment of other diseases and conditions. Examples of radiopharmaceuticals include technetium-99m for imaging the heart, lungs, and bones; iodine-131 for treating thyroid cancer; and samarium-153 for palliative treatment of bone metastases.

The use of radiopharmaceuticals requires specialized training and expertise in nuclear medicine, as well as strict adherence to safety protocols to minimize radiation exposure to patients and healthcare workers.

Capillary electrochromatography (CEC) is a separation technique that combines the principles of capillary electrophoresis and high-performance liquid chromatography (HPLC). In CEC, an electric field is applied to a liquid flowing through a narrow fused-silica capillary tube packed with a stationary phase.

The analytes (the substances being separated) are carried by the electroosmotic flow of the liquid and interact with the stationary phase as they migrate through the capillary, resulting in separation based on both charge and size/hydrophobicity. CEC offers high efficiency, resolution, and sensitivity for the separation of a wide range of analytes, including small molecules, peptides, proteins, and nucleic acids.

The medical definition of Capillary Electrochromatography is not commonly used as it is primarily employed in research settings for the analysis of various biological samples, pharmaceuticals, and environmental pollutants.

Corneal pachymetry is a medical measurement of the thickness of the cornea, which is the clear, dome-shaped surface at the front of the eye. This measurement is typically taken using a specialized instrument called a pachymeter. The procedure is quick, painless, and non-invasive.

Corneal pachymetry is an essential test in optometry and ophthalmology for various reasons. For instance, it helps assess the overall health of the cornea, identify potential abnormalities or diseases, and determine the correct intraocular lens power during cataract surgery. Additionally, corneal thickness is a crucial factor in determining a person's risk for developing glaucoma and monitoring the progression of the disease.

In some cases, such as with contact lens fitting, corneal pachymetry can help ensure proper fit and minimize potential complications. Overall, corneal pachymetry is an essential diagnostic tool in eye care that provides valuable information for maintaining eye health and ensuring appropriate treatment.

Mass spectrometry (MS) is an analytical technique used to identify and quantify the chemical components of a mixture or compound. It works by ionizing the sample, generating charged molecules or fragments, and then measuring their mass-to-charge ratio in a vacuum. The resulting mass spectrum provides information about the molecular weight and structure of the analytes, allowing for identification and characterization.

In simpler terms, mass spectrometry is a method used to determine what chemicals are present in a sample and in what quantities, by converting the chemicals into ions, measuring their masses, and generating a spectrum that shows the relative abundances of each ion type.

Cephalometry is a medical term that refers to the measurement and analysis of the skull, particularly the head face relations. It is commonly used in orthodontics and maxillofacial surgery to assess and plan treatment for abnormalities related to the teeth, jaws, and facial structures. The process typically involves taking X-ray images called cephalograms, which provide a lateral view of the head, and then using various landmarks and reference lines to make measurements and evaluate skeletal and dental relationships. This information can help clinicians diagnose problems, plan treatment, and assess treatment outcomes.

The knee joint, also known as the tibiofemoral joint, is the largest and one of the most complex joints in the human body. It is a synovial joint that connects the thighbone (femur) to the shinbone (tibia). The patella (kneecap), which is a sesamoid bone, is located in front of the knee joint and helps in the extension of the leg.

The knee joint is made up of three articulations: the femorotibial joint between the femur and tibia, the femoropatellar joint between the femur and patella, and the tibiofibular joint between the tibia and fibula. These articulations are surrounded by a fibrous capsule that encloses the synovial membrane, which secretes synovial fluid to lubricate the joint.

The knee joint is stabilized by several ligaments, including the medial and lateral collateral ligaments, which provide stability to the sides of the joint, and the anterior and posterior cruciate ligaments, which prevent excessive forward and backward movement of the tibia relative to the femur. The menisci, which are C-shaped fibrocartilaginous structures located between the femoral condyles and tibial plateaus, also help to stabilize the joint by absorbing shock and distributing weight evenly across the articular surfaces.

The knee joint allows for flexion, extension, and a small amount of rotation, making it essential for activities such as walking, running, jumping, and sitting.

Laboratory proficiency testing (PT) is a systematic process used to evaluate the performance of a laboratory in accurately and consistently performing specific tests or procedures. It involves the analysis of blinded samples with known or expected values, which are distributed by an independent proficiency testing provider to participating laboratories. The results from each laboratory are then compared to the target value or the range of acceptable values, allowing for the assessment of a laboratory's accuracy, precision, and consistency over time.

Proficiency testing is an essential component of quality assurance programs in clinical, research, and industrial laboratories. It helps laboratories identify and address sources of error, improve their analytical methods, and maintain compliance with regulatory requirements and accreditation standards. Regular participation in proficiency testing programs also promotes confidence in the accuracy and reliability of laboratory test results, ultimately benefiting patient care, research outcomes, and public health.

Positron-Emission Tomography (PET) is a type of nuclear medicine imaging that uses small amounts of radioactive material, called a radiotracer, to produce detailed, three-dimensional images. This technique measures metabolic activity within the body, such as sugar metabolism, to help distinguish between healthy and diseased tissue, identify cancerous cells, or examine the function of organs.

During a PET scan, the patient is injected with a radiotracer, typically a sugar-based compound labeled with a positron-emitting radioisotope, such as fluorine-18 (^18^F). The radiotracer accumulates in cells that are metabolically active, like cancer cells. As the radiotracer decays, it emits positrons, which then collide with electrons in nearby tissue, producing gamma rays. A special camera, called a PET scanner, detects these gamma rays and uses this information to create detailed images of the body's internal structures and processes.

PET is often used in conjunction with computed tomography (CT) or magnetic resonance imaging (MRI) to provide both functional and anatomical information, allowing for more accurate diagnosis and treatment planning. Common applications include detecting cancer recurrence, staging and monitoring cancer, evaluating heart function, and assessing brain function in conditions like dementia and epilepsy.

Statistical data interpretation involves analyzing and interpreting numerical data in order to identify trends, patterns, and relationships. This process often involves the use of statistical methods and tools to organize, summarize, and draw conclusions from the data. The goal is to extract meaningful insights that can inform decision-making, hypothesis testing, or further research.

In medical contexts, statistical data interpretation is used to analyze and make sense of large sets of clinical data, such as patient outcomes, treatment effectiveness, or disease prevalence. This information can help healthcare professionals and researchers better understand the relationships between various factors that impact health outcomes, develop more effective treatments, and identify areas for further study.

Some common statistical methods used in data interpretation include descriptive statistics (e.g., mean, median, mode), inferential statistics (e.g., hypothesis testing, confidence intervals), and regression analysis (e.g., linear, logistic). These methods can help medical professionals identify patterns and trends in the data, assess the significance of their findings, and make evidence-based recommendations for patient care or public health policy.

I'm sorry for any confusion, but "Linear Models" is actually a term from the field of statistics and machine learning, rather than medicine. A linear model is a type of statistical model that is used to analyze the relationship between two or more variables. In a linear model, the relationship between the dependent variable (the outcome or result) and the independent variable(s) (the factors being studied) is assumed to be linear, meaning that it can be described by a straight line on a graph.

The equation for a simple linear model with one independent variable (x) and one dependent variable (y) looks like this:

y = β0 + β1*x + ε

In this equation, β0 is the y-intercept or the value of y when x equals zero, β1 is the slope or the change in y for each unit increase in x, and ε is the error term or the difference between the actual values of y and the predicted values of y based on the linear model.

Linear models are widely used in medical research to study the relationship between various factors (such as exposure to a risk factor or treatment) and health outcomes (such as disease incidence or mortality). They can also be used to adjust for confounding variables, which are factors that may influence both the independent variable and the dependent variable, and thus affect the observed relationship between them.

Statistics, as a topic in the context of medicine and healthcare, refers to the scientific discipline that involves the collection, analysis, interpretation, and presentation of numerical data or quantifiable data in a meaningful and organized manner. It employs mathematical theories and models to draw conclusions, make predictions, and support evidence-based decision-making in various areas of medical research and practice.

Some key concepts and methods in medical statistics include:

1. Descriptive Statistics: Summarizing and visualizing data through measures of central tendency (mean, median, mode) and dispersion (range, variance, standard deviation).
2. Inferential Statistics: Drawing conclusions about a population based on a sample using hypothesis testing, confidence intervals, and statistical modeling.
3. Probability Theory: Quantifying the likelihood of events or outcomes in medical scenarios, such as diagnostic tests' sensitivity and specificity.
4. Study Designs: Planning and implementing various research study designs, including randomized controlled trials (RCTs), cohort studies, case-control studies, and cross-sectional surveys.
5. Sampling Methods: Selecting a representative sample from a population to ensure the validity and generalizability of research findings.
6. Multivariate Analysis: Examining the relationships between multiple variables simultaneously using techniques like regression analysis, factor analysis, or cluster analysis.
7. Survival Analysis: Analyzing time-to-event data, such as survival rates in clinical trials or disease progression.
8. Meta-Analysis: Systematically synthesizing and summarizing the results of multiple studies to provide a comprehensive understanding of a research question.
9. Biostatistics: A subfield of statistics that focuses on applying statistical methods to biological data, including medical research.
10. Epidemiology: The study of disease patterns in populations, which often relies on statistical methods for data analysis and interpretation.

Medical statistics is essential for evidence-based medicine, clinical decision-making, public health policy, and healthcare management. It helps researchers and practitioners evaluate the effectiveness and safety of medical interventions, assess risk factors and outcomes associated with diseases or treatments, and monitor trends in population health.

Blood chemical analysis, also known as clinical chemistry or chemistry panel, is a series of tests that measure the levels of various chemicals in the blood. These tests can help evaluate the function of organs such as the kidneys and liver, and can also detect conditions such as diabetes and heart disease.

The tests typically include:

* Glucose: to check for diabetes
* Electrolytes (such as sodium, potassium, chloride, and bicarbonate): to check the body's fluid and electrolyte balance
* Calcium: to check for problems with bones, nerves, or kidneys
* Creatinine: to check for kidney function
* Urea Nitrogen (BUN): to check for kidney function
* Albumin: to check for liver function and nutrition status
* ALT (Alanine Transaminase) and AST (Aspartate Transaminase): to check for liver function
* Alkaline Phosphatase: to check for liver or bone disease
* Total Bilirubin: to check for liver function and gallbladder function
* Cholesterol: to check for heart disease risk
* Triglycerides: to check for heart disease risk

These tests are usually ordered by a doctor as part of a routine check-up, or to help diagnose and monitor specific medical conditions. The results of the blood chemical analysis are compared to reference ranges provided by the laboratory performing the test, which take into account factors such as age, sex, and race.

Pathology is a significant branch of medical science that deals with the study of the nature of diseases, their causes, processes, development, and consequences. It involves the examination of tissues, organs, bodily fluids, and autopsies to diagnose disease and determine the course of treatment. Pathology can be divided into various sub-specialties such as anatomical pathology, clinical pathology, molecular pathology, and forensic pathology. Ultimately, pathology aims to understand the mechanisms of diseases and improve patient care through accurate diagnosis and effective treatment plans.

Analytical chemistry techniques are a collection of methods and tools used to identify and quantify the chemical composition of matter. These techniques can be used to analyze the presence and amount of various chemicals in a sample, including ions, molecules, and atoms. Some common analytical chemistry techniques include:

1. Spectroscopy: This technique uses the interaction between electromagnetic radiation and matter to identify and quantify chemical species. There are many different types of spectroscopy, including UV-Vis, infrared (IR), fluorescence, and nuclear magnetic resonance (NMR) spectroscopy.
2. Chromatography: This technique separates the components of a mixture based on their physical or chemical properties, such as size, charge, or polarity. Common types of chromatography include gas chromatography (GC), liquid chromatography (LC), and thin-layer chromatography (TLC).
3. Mass spectrometry: This technique uses the mass-to-charge ratio of ions to identify and quantify chemical species. It can be used in combination with other techniques, such as GC or LC, to provide structural information about unknown compounds.
4. Electrochemical methods: These techniques use the movement of electrons to measure the concentration of chemical species. Examples include potentiometry, voltammetry, and amperometry.
5. Thermal analysis: This technique uses changes in the physical or chemical properties of a sample as it is heated or cooled to identify and quantify chemical species. Examples include differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).

These are just a few examples of the many analytical chemistry techniques that are available. Each technique has its own strengths and limitations, and the choice of which to use will depend on the specific needs of the analysis.

In medical terms, the "head" is the uppermost part of the human body that contains the brain, skull, face, eyes, nose, mouth, and ears. It is connected to the rest of the body by the neck and is responsible for many vital functions such as sight, hearing, smell, taste, touch, and thought processing. The head also plays a crucial role in maintaining balance, speech, and eating.

Proteomics is the large-scale study and analysis of proteins, including their structures, functions, interactions, modifications, and abundance, in a given cell, tissue, or organism. It involves the identification and quantification of all expressed proteins in a biological sample, as well as the characterization of post-translational modifications, protein-protein interactions, and functional pathways. Proteomics can provide valuable insights into various biological processes, diseases, and drug responses, and has applications in basic research, biomedicine, and clinical diagnostics. The field combines various techniques from molecular biology, chemistry, physics, and bioinformatics to study proteins at a systems level.

Equipment Failure Analysis is a process of identifying the cause of failure in medical equipment or devices. This involves a systematic examination and evaluation of the equipment, its components, and operational history to determine why it failed. The analysis may include physical inspection, chemical testing, and review of maintenance records, as well as assessment of design, manufacturing, and usage factors that may have contributed to the failure.

The goal of Equipment Failure Analysis is to identify the root cause of the failure, so that corrective actions can be taken to prevent similar failures in the future. This is important in medical settings to ensure patient safety and maintain the reliability and effectiveness of medical equipment.

Ultrasonography, Doppler refers to a non-invasive diagnostic medical procedure that uses high-frequency sound waves to create real-time images of the movement of blood flow through vessels, tissues, or heart valves. The Doppler effect is used to measure the frequency shift of the ultrasound waves as they bounce off moving red blood cells, which allows for the calculation of the speed and direction of blood flow. This technique is commonly used to diagnose and monitor various conditions such as deep vein thrombosis, carotid artery stenosis, heart valve abnormalities, and fetal heart development during pregnancy. It does not use radiation or contrast agents and is considered safe with minimal risks.

Dental digital radiography is a type of medical imaging that uses digital sensors instead of traditional X-ray film to produce highly detailed images of the teeth, gums, and surrounding structures. This technology offers several advantages over conventional dental radiography, including:

1. Lower radiation exposure: Digital sensors require less radiation to produce an image compared to traditional film, making it a safer option for patients.
2. Instant results: The images captured by digital sensors are immediately displayed on a computer screen, allowing dentists to quickly assess the patient's oral health and discuss any findings with them during the appointment.
3. Improved image quality: Digital radiography produces clearer and more precise images compared to traditional film, enabling dentists to better detect issues such as cavities, fractures, or tumors.
4. Enhanced communication: The ability to easily manipulate and enhance digital images allows for better communication between dental professionals and improved patient education.
5. Environmentally friendly: Digital radiography eliminates the need for chemical processing and disposal of used film, making it a more environmentally conscious choice.
6. Easy storage and retrieval: Digital images can be stored electronically and accessed easily for future reference or consultation with other dental professionals.
7. Remote consultations: Digital images can be shared remotely with specialists or insurance companies, facilitating faster diagnoses and treatment planning.

A biological marker, often referred to as a biomarker, is a measurable indicator that reflects the presence or severity of a disease state, or a response to a therapeutic intervention. Biomarkers can be found in various materials such as blood, tissues, or bodily fluids, and they can take many forms, including molecular, histologic, radiographic, or physiological measurements.

In the context of medical research and clinical practice, biomarkers are used for a variety of purposes, such as:

1. Diagnosis: Biomarkers can help diagnose a disease by indicating the presence or absence of a particular condition. For example, prostate-specific antigen (PSA) is a biomarker used to detect prostate cancer.
2. Monitoring: Biomarkers can be used to monitor the progression or regression of a disease over time. For instance, hemoglobin A1c (HbA1c) levels are monitored in diabetes patients to assess long-term blood glucose control.
3. Predicting: Biomarkers can help predict the likelihood of developing a particular disease or the risk of a negative outcome. For example, the presence of certain genetic mutations can indicate an increased risk for breast cancer.
4. Response to treatment: Biomarkers can be used to evaluate the effectiveness of a specific treatment by measuring changes in the biomarker levels before and after the intervention. This is particularly useful in personalized medicine, where treatments are tailored to individual patients based on their unique biomarker profiles.

It's important to note that for a biomarker to be considered clinically valid and useful, it must undergo rigorous validation through well-designed studies, including demonstrating sensitivity, specificity, reproducibility, and clinical relevance.

Biosensing techniques refer to the methods and technologies used to detect and measure biological molecules or processes, typically through the use of a physical device or sensor. These techniques often involve the conversion of a biological response into an electrical signal that can be measured and analyzed. Examples of biosensing techniques include electrochemical biosensors, optical biosensors, and piezoelectric biosensors.

Electrochemical biosensors measure the electrical current or potential generated by a biochemical reaction at an electrode surface. This type of biosensor typically consists of a biological recognition element, such as an enzyme or antibody, that is immobilized on the electrode surface and interacts with the target analyte to produce an electrical signal.

Optical biosensors measure changes in light intensity or wavelength that occur when a biochemical reaction takes place. This type of biosensor can be based on various optical principles, such as absorbance, fluorescence, or surface plasmon resonance (SPR).

Piezoelectric biosensors measure changes in mass or frequency that occur when a biomolecule binds to the surface of a piezoelectric crystal. This type of biosensor is based on the principle that piezoelectric materials generate an electrical charge when subjected to mechanical stress, and this charge can be used to detect changes in mass or frequency that are proportional to the amount of biomolecule bound to the surface.

Biosensing techniques have a wide range of applications in fields such as medicine, environmental monitoring, food safety, and biodefense. They can be used to detect and measure a variety of biological molecules, including proteins, nucleic acids, hormones, and small molecules, as well as to monitor biological processes such as cell growth or metabolism.

Ocular tonometry is a medical test used to measure the pressure inside the eye, also known as intraocular pressure (IOP). This test is an essential part of diagnosing and monitoring glaucoma, a group of eye conditions that can cause vision loss and blindness due to damage to the optic nerve from high IOP.

The most common method of ocular tonometry involves using a tonometer device that gently touches the front surface of the eye (cornea) with a small probe or prism. The device measures the amount of force required to flatten the cornea slightly, which correlates with the pressure inside the eye. Other methods of ocular tonometry include applanation tonometry, which uses a small amount of fluorescein dye and a blue light to measure the IOP, and rebound tonometry, which uses a lightweight probe that briefly touches the cornea and then bounces back to determine the IOP.

Regular ocular tonometry is important for detecting glaucoma early and preventing vision loss. It is typically performed during routine eye exams and may be recommended more frequently for individuals at higher risk of developing glaucoma, such as those with a family history of the condition or certain medical conditions like diabetes.

An electrode is a medical device that can conduct electrical currents and is used to transmit or receive electrical signals, often in the context of medical procedures or treatments. In a medical setting, electrodes may be used for a variety of purposes, such as:

1. Recording electrical activity in the body: Electrodes can be attached to the skin or inserted into body tissues to measure electrical signals produced by the heart, brain, muscles, or nerves. This information can be used to diagnose medical conditions, monitor the effectiveness of treatments, or guide medical procedures.
2. Stimulating nerve or muscle activity: Electrodes can be used to deliver electrical impulses to nerves or muscles, which can help to restore function or alleviate symptoms in people with certain medical conditions. For example, electrodes may be used to stimulate the nerves that control bladder function in people with spinal cord injuries, or to stimulate muscles in people with muscle weakness or paralysis.
3. Administering treatments: Electrodes can also be used to deliver therapeutic treatments, such as transcranial magnetic stimulation (TMS) for depression or deep brain stimulation (DBS) for movement disorders like Parkinson's disease. In these procedures, electrodes are implanted in specific areas of the brain and connected to a device that generates electrical impulses, which can help to regulate abnormal brain activity and improve symptoms.

Overall, electrodes play an important role in many medical procedures and treatments, allowing healthcare professionals to diagnose and treat a wide range of conditions that affect the body's electrical systems.

The macula lutea, often simply referred to as the macula or fovea centralis, is a part of the eye that is responsible for central vision and color perception. It's located in the center of the retina, the light-sensitive tissue at the back of the eye. The macula contains a high concentration of pigments called xanthophylls, which give it a yellowish color and protect the photoreceptor cells in this area from damage by blue light.

The central part of the macula is called the fovea, which is a small depression that contains only cones, the photoreceptor cells responsible for color vision and high visual acuity. The fovea is surrounded by the parafovea and the perifovea, which contain both cones and rods, the photoreceptor cells responsible for low-light vision and peripheral vision.

Damage to the macula can result in a loss of central vision and color perception, a condition known as age-related macular degeneration (AMD), which is a leading cause of blindness in older adults. Other conditions that can affect the macula include macular edema, macular holes, and macular pucker.

An artifact, in the context of medical terminology, refers to something that is created or introduced during a scientific procedure or examination that does not naturally occur in the patient or specimen being studied. Artifacts can take many forms and can be caused by various factors, including contamination, damage, degradation, or interference from equipment or external sources.

In medical imaging, for example, an artifact might appear as a distortion or anomaly on an X-ray, MRI, or CT scan that is not actually present in the patient's body. This can be caused by factors such as patient movement during the scan, metal implants or other foreign objects in the body, or issues with the imaging equipment itself.

Similarly, in laboratory testing, an artifact might refer to a substance or characteristic that is introduced into a sample during collection, storage, or analysis that can interfere with accurate results. This could include things like contamination from other samples, degradation of the sample over time, or interference from chemicals used in the testing process.

In general, artifacts are considered to be sources of error or uncertainty in medical research and diagnosis, and it is important to identify and account for them in order to ensure accurate and reliable results.

I'm sorry for any confusion, but "Microchemistry" is not a commonly used term in medicine. It is, however, a branch of chemistry that deals with the separation, identification, and analysis of chemical substances in minute quantities. This field can be applied in various scientific disciplines, including forensic science, environmental science, and materials science.

In the medical field, you might encounter similar concepts under terms like "microanalysis" or "clinical chemistry," which refer to the identification and measurement of chemical components in body fluids (like blood or urine) for diagnostic purposes. But again, "Microchemistry" is not a standard term used in this context.

Dental radiography is a specific type of imaging that uses radiation to produce detailed images of the teeth, bones, and soft tissues surrounding them. It is a crucial tool in dental diagnostics and treatment planning. There are several types of dental radiographs, including:

1. Intraoral Radiographs: These are taken inside the mouth and provide detailed images of individual teeth or small groups of teeth. They can help detect cavities, assess periodontal health, plan for restorations, and monitor tooth development in children. Common types of intraoral radiographs include bitewing, periapical, and occlusal radiographs.
2. Extraoral Radiographs: These are taken outside the mouth and provide images of larger areas, such as the entire jaw or skull. They can help diagnose issues related to the temporomandibular joint (TMJ), detect impacted teeth, assess bone health, and identify any abnormalities in the facial structure. Common types of extraoral radiographs include panoramic, cephalometric, and sialography radiographs.
3. Cone Beam Computed Tomography (CBCT): This is a specialized type of dental radiography that uses a cone-shaped X-ray beam to create detailed 3D images of the teeth, bones, and soft tissues. It is particularly useful in planning complex treatments such as dental implants, orthodontic treatment, and oral surgery.

Dental radiographs are typically taken using a specialized machine that emits a low dose of radiation. Patients are provided with protective lead aprons to minimize exposure to radiation. The frequency of dental radiographs depends on the patient's individual needs and medical history. Dentists follow strict guidelines to ensure that dental radiography is safe and effective for their patients.

Arthrometry is a measurement technique used in the field of orthopedics and rheumatology to assess the integrity and mobility of joints. When qualified with the term "articular," it specifically refers to the measurement of articular motion or range of motion (ROM) within a synovial joint.

Articular arthrometry involves using specialized instruments, such as goniometers, inclinometers, or digital devices like smartphone applications and wearable sensors, to quantify the degree of flexion, extension, abduction, adduction, rotation, or other movements in a joint. This information can help medical professionals evaluate joint function, diagnose injuries or conditions affecting joint mobility, monitor disease progression, and assess treatment outcomes.

In summary, articular arthrometry is the measurement of articular motion within synovial joints to evaluate joint health and function.

Ultrasonography, also known as sonography, is a diagnostic medical procedure that uses high-frequency sound waves (ultrasound) to produce dynamic images of organs, tissues, or blood flow inside the body. These images are captured in real-time and can be used to assess the size, shape, and structure of various internal structures, as well as detect any abnormalities such as tumors, cysts, or inflammation.

During an ultrasonography procedure, a small handheld device called a transducer is placed on the patient's skin, which emits and receives sound waves. The transducer sends high-frequency sound waves into the body, and these waves bounce back off internal structures and are recorded by the transducer. The recorded data is then processed and transformed into visual images that can be interpreted by a medical professional.

Ultrasonography is a non-invasive, painless, and safe procedure that does not use radiation like other imaging techniques such as CT scans or X-rays. It is commonly used to diagnose and monitor conditions in various parts of the body, including the abdomen, pelvis, heart, blood vessels, and musculoskeletal system.

Computer-assisted signal processing is a medical term that refers to the use of computer algorithms and software to analyze, interpret, and extract meaningful information from biological signals. These signals can include physiological data such as electrocardiogram (ECG) waves, electromyography (EMG) signals, electroencephalography (EEG) readings, or medical images.

The goal of computer-assisted signal processing is to automate the analysis of these complex signals and extract relevant features that can be used for diagnostic, monitoring, or therapeutic purposes. This process typically involves several steps, including:

1. Signal acquisition: Collecting raw data from sensors or medical devices.
2. Preprocessing: Cleaning and filtering the data to remove noise and artifacts.
3. Feature extraction: Identifying and quantifying relevant features in the signal, such as peaks, troughs, or patterns.
4. Analysis: Applying statistical or machine learning algorithms to interpret the extracted features and make predictions about the underlying physiological state.
5. Visualization: Presenting the results in a clear and intuitive way for clinicians to review and use.

Computer-assisted signal processing has numerous applications in healthcare, including:

* Diagnosing and monitoring cardiac arrhythmias or other heart conditions using ECG signals.
* Assessing muscle activity and function using EMG signals.
* Monitoring brain activity and diagnosing neurological disorders using EEG readings.
* Analyzing medical images to detect abnormalities, such as tumors or fractures.

Overall, computer-assisted signal processing is a powerful tool for improving the accuracy and efficiency of medical diagnosis and monitoring, enabling clinicians to make more informed decisions about patient care.

I'm sorry for any confusion, but Fourier Analysis is not a medical term. It is a mathematical concept used in various scientific fields, including physics, engineering, and signal processing.

Fourier Analysis is a method to decompose functions into sinusoidal components (sines and cosines) of different frequencies. This allows for the representation of a function or a signal as a sum of these frequency components. It's particularly useful in analyzing periodic functions, understanding signals, and solving partial differential equations.

If you have any medical terms you would like me to define, please let me know!

Posture is the position or alignment of body parts supported by the muscles, especially the spine and head in relation to the vertebral column. It can be described as static (related to a stationary position) or dynamic (related to movement). Good posture involves training your body to stand, walk, sit, and lie in positions where the least strain is placed on supporting muscles and ligaments during movement or weight-bearing activities. Poor posture can lead to various health issues such as back pain, neck pain, headaches, and respiratory problems.

Bacterial typing techniques are methods used to identify and differentiate bacterial strains or isolates based on their unique characteristics. These techniques are essential in epidemiological studies, infection control, and research to understand the transmission dynamics, virulence, and antibiotic resistance patterns of bacterial pathogens.

There are various bacterial typing techniques available, including:

1. **Bacteriophage Typing:** This method involves using bacteriophages (viruses that infect bacteria) to identify specific bacterial strains based on their susceptibility or resistance to particular phages.
2. **Serotyping:** It is a technique that differentiates bacterial strains based on the antigenic properties of their cell surface components, such as capsules, flagella, and somatic (O) and flagellar (H) antigens.
3. **Biochemical Testing:** This method uses biochemical reactions to identify specific metabolic pathways or enzymes present in bacterial strains, which can be used for differentiation. Commonly used tests include the catalase test, oxidase test, and various sugar fermentation tests.
4. **Molecular Typing Techniques:** These methods use genetic markers to identify and differentiate bacterial strains at the DNA level. Examples of molecular typing techniques include:
* **Pulsed-Field Gel Electrophoresis (PFGE):** This method uses restriction enzymes to digest bacterial DNA, followed by electrophoresis in an agarose gel under pulsed electrical fields. The resulting banding patterns are analyzed and compared to identify related strains.
* **Multilocus Sequence Typing (MLST):** It involves sequencing specific housekeeping genes to generate unique sequence types that can be used for strain identification and phylogenetic analysis.
* **Whole Genome Sequencing (WGS):** This method sequences the entire genome of a bacterial strain, providing the most detailed information on genetic variation and relatedness between strains. WGS data can be analyzed using various bioinformatics tools to identify single nucleotide polymorphisms (SNPs), gene deletions or insertions, and other genetic changes that can be used for strain differentiation.

These molecular typing techniques provide higher resolution than traditional methods, allowing for more accurate identification and comparison of bacterial strains. They are particularly useful in epidemiological investigations to track the spread of pathogens and identify outbreaks.

Prenatal ultrasonography, also known as obstetric ultrasound, is a medical diagnostic procedure that uses high-frequency sound waves to create images of the developing fetus, placenta, and amniotic fluid inside the uterus. It is a non-invasive and painless test that is widely used during pregnancy to monitor the growth and development of the fetus, detect any potential abnormalities or complications, and determine the due date.

During the procedure, a transducer (a small handheld device) is placed on the mother's abdomen and moved around to capture images from different angles. The sound waves travel through the mother's body and bounce back off the fetus, producing echoes that are then converted into electrical signals and displayed as images on a screen.

Prenatal ultrasonography can be performed at various stages of pregnancy, including early pregnancy to confirm the pregnancy and detect the number of fetuses, mid-pregnancy to assess the growth and development of the fetus, and late pregnancy to evaluate the position of the fetus and determine if it is head down or breech. It can also be used to guide invasive procedures such as amniocentesis or chorionic villus sampling.

Overall, prenatal ultrasonography is a valuable tool in modern obstetrics that helps ensure the health and well-being of both the mother and the developing fetus.

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic technique that uses a strong magnetic field and radio waves to create detailed cross-sectional images of the body's internal structures. In MRI, Cine is a specific mode of imaging that allows for the evaluation of moving structures, such as the heart, by acquiring and displaying a series of images in rapid succession. This technique is particularly useful in cardiac imaging, where it can help assess heart function, valve function, and blood flow. The term "Cine" refers to the continuous playback of these images, similar to watching a movie, allowing doctors to evaluate motion and timing within the heart.

Cone-beam computed tomography (CBCT) is a medical imaging technique that uses a cone-shaped X-ray beam to create detailed, cross-sectional images of the body. In dental and maxillofacial radiology, CBCT is used to produce three-dimensional images of the teeth, jaws, and surrounding bones.

CBCT differs from traditional computed tomography (CT) in that it uses a cone-shaped X-ray beam instead of a fan-shaped beam, which allows for a faster scan time and lower radiation dose. The X-ray beam is rotated around the patient's head, capturing data from multiple angles, which is then reconstructed into a three-dimensional image using specialized software.

CBCT is commonly used in dental implant planning, orthodontic treatment planning, airway analysis, and the diagnosis and management of jaw pathologies such as tumors and fractures. It provides detailed information about the anatomy of the teeth, jaws, and surrounding structures, which can help clinicians make more informed decisions about patient care.

However, it is important to note that CBCT should only be used when necessary, as it still involves exposure to ionizing radiation. The benefits of using CBCT must be weighed against the potential risks associated with radiation exposure.

Analytical sample preparation methods refer to the procedures and techniques used to manipulate and treat samples in order to make them suitable for analysis by an analytical instrument. The main goal of these methods is to isolate, concentrate, and purify the analytes of interest from a complex matrix, while also minimizing interference and improving the accuracy, precision, and sensitivity of the analysis.

Some common analytical sample preparation methods include:

1. Extraction: This involves separating the analyte from the sample matrix using a solvent or other medium. Examples include liquid-liquid extraction (LLE), solid-phase extraction (SPE), and microwave-assisted extraction (MAE).
2. Purification: This step is used to remove impurities and interfering substances from the sample. Common methods include column chromatography, gel permeation chromatography, and distillation.
3. Derivatization: This involves chemically modifying the analyte to improve its detectability or stability. Examples include silylation, acetylation, and esterification.
4. Digestion: This step is used to break down complex samples into smaller, more manageable components. Examples include acid digestion, dry ashing, and microwave digestion.
5. Concentration: This step is used to increase the amount of analyte in the sample, making it easier to detect. Examples include evaporation, lyophilization, and rotary evaporation.

These methods are widely used in various fields such as forensics, environmental science, food analysis, pharmaceuticals, and clinical diagnostics to ensure accurate and reliable results.

Indicator dilution techniques are a group of methods used in medicine and research to measure various physiological variables, such as cardiac output or cerebral blood flow. These techniques involve introducing a known quantity of an indicator substance (like a dye or a radioactive tracer) into the system being studied and then measuring its concentration over time at a specific location downstream.

The basic principle behind these techniques is that the concentration of the indicator substance will be inversely proportional to the flow rate of the fluid through which it is moving. By measuring the concentration of the indicator substance at different points in time, researchers can calculate the flow rate using mathematical formulas.

Indicator dilution techniques are widely used in clinical and research settings because they are relatively non-invasive and can provide accurate and reliable measurements of various physiological variables. Some common examples of indicator dilution techniques include thermodilution, dye dilution, and Fick principle-based methods.

A "Seveso accidental release" refers to an unintentional and sudden escape of hazardous substances that can lead to harmful impacts on human health and the environment. The term is derived from the Seveso Disaster, which occurred in 1976 in Seveso, Italy, when a chemical factory released toxic dioxin gas, leading to significant health and environmental consequences.

The Seveso accidental release is now used more broadly to refer to any industrial accident that results in the uncontrolled release of hazardous substances. The European Union (EU) has established a regulatory framework known as the "Seveso Directives" to prevent and mitigate such accidents, which requires industries handling dangerous substances to implement safety measures and emergency plans.

The Seveso accidental release is defined by the EU's Seveso III Directive (2012/18/EU) as "any sudden or non-sudden occurrence such as a fire, explosion or any other kind of accident resulting from uncontrolled developments in the course of the operation of any establishment covered by this Directive, and leading to a significant emission, fire, explosion or any other kind of accident."

A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.

Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.

It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.

Oxygen radioisotopes are unstable isotopes of the element oxygen that emit radiation as they decay to a more stable form. These isotopes can be used in medical imaging and treatment, such as positron emission tomography (PET) scans. Common oxygen radioisotopes used in medicine include oxygen-15 and oxygen-18. Oxygen-15 has a very short half-life of about 2 minutes, while oxygen-18 has a longer half-life of about 2 hours. These isotopes can be incorporated into molecules such as water or carbon dioxide, which can then be used to study blood flow, metabolism and other physiological processes in the body.

A computer is a programmable electronic device that can store, retrieve, and process data. It is composed of several components including:

1. Hardware: The physical components of a computer such as the central processing unit (CPU), memory (RAM), storage devices (hard drive or solid-state drive), and input/output devices (monitor, keyboard, and mouse).
2. Software: The programs and instructions that are used to perform specific tasks on a computer. This includes operating systems, applications, and utilities.
3. Input: Devices or methods used to enter data into a computer, such as a keyboard, mouse, scanner, or digital camera.
4. Processing: The function of the CPU in executing instructions and performing calculations on data.
5. Output: The results of processing, which can be displayed on a monitor, printed on paper, or saved to a storage device.

Computers come in various forms and sizes, including desktop computers, laptops, tablets, and smartphones. They are used in a wide range of applications, from personal use for communication, entertainment, and productivity, to professional use in fields such as medicine, engineering, finance, and education.

I'm sorry for any confusion, but "Weights and Measures" is not a term that has a specific medical definition. It is a term used in various fields, including science, engineering, and commerce, to refer to systems and standards used to measure weight, length, volume, and other physical quantities.

However, if you're asking about the use of weights and measures in a medical context, it might refer to the standardized units of measurement used to quantify various aspects of health, disease, and treatment. For example:

* Weight: Measured in kilograms (kg) or pounds (lb), this is a measure of a person's mass.
* Height: Measured in meters (m) or feet/inches (ft/in), this is a measure of a person's height.
* Blood pressure: Measured in millimeters of mercury (mmHg), this is a measure of the force exerted by blood on the walls of the arteries.
* Temperature: Measured in degrees Celsius (°C) or Fahrenheit (°F), this is a measure of body temperature.
* Laboratory values: Various substances in the body, such as glucose or cholesterol, are measured in standardized units, such as millimoles per liter (mmol/L) or milligrams per deciliter (mg/dL).

These measurements help healthcare professionals assess a person's health status, diagnose medical conditions, and monitor the effects of treatment.

Breath holding is a physiological response where an individual holds their breath, intentionally or unintentionally, for a period of time. This can occur in various situations such as during swimming underwater, while lifting heavy weights, or in response to emotional stress or pain. In some cases, it can also be associated with certain medical conditions like seizures or syncope (fainting).

In the context of medical terminology, breath holding is often described as "voluntary" or "involuntary." Voluntary breath-holding is when an individual consciously chooses to hold their breath, while involuntary breath-holding occurs unconsciously, usually in response to a trigger such as a sudden increase in carbon dioxide levels or a decrease in oxygen levels.

It's important to note that prolonged breath-holding can be dangerous and may lead to hypoxia (lack of oxygen) and hypercapnia (excessive carbon dioxide), which can cause dizziness, loss of consciousness, or even more severe consequences such as brain damage or death. Therefore, it's essential not to hold one's breath for extended periods and seek medical attention if experiencing any symptoms related to breath-holding.

Cross-sectional anatomy refers to the study and visualization of the internal structures of the body as if they were cut along a plane, creating a two-dimensional image. This method allows for a detailed examination of the relationships between various organs, tissues, and structures that may not be as easily appreciated through traditional observation or examination.

In cross-sectional anatomy, different imaging techniques such as computed tomography (CT) scans, magnetic resonance imaging (MRI), and ultrasound are used to create detailed images of the body's internal structures at various depths and planes. These images can help medical professionals diagnose conditions, plan treatments, and assess the effectiveness of interventions.

Cross-sectional anatomy is an important tool in modern medicine, as it provides a more comprehensive understanding of the human body than traditional gross anatomy alone. By allowing for a detailed examination of the internal structures of the body, cross-sectional anatomy can help medical professionals make more informed decisions about patient care.

Tandem mass spectrometry (MS/MS) is a technique used to identify and quantify specific molecules, such as proteins or metabolites, within complex mixtures. This method uses two or more sequential mass analyzers to first separate ions based on their mass-to-charge ratio and then further fragment the selected ions into smaller pieces for additional analysis. The fragmentation patterns generated in MS/MS experiments can be used to determine the structure and identity of the original molecule, making it a powerful tool in various fields such as proteomics, metabolomics, and forensic science.

An immunoassay is a biochemical test that measures the presence or concentration of a specific protein, antibody, or antigen in a sample using the principles of antibody-antigen reactions. It is commonly used in clinical laboratories to diagnose and monitor various medical conditions such as infections, hormonal disorders, allergies, and cancer.

Immunoassays typically involve the use of labeled reagents, such as enzymes, radioisotopes, or fluorescent dyes, that bind specifically to the target molecule. The amount of label detected is proportional to the concentration of the target molecule in the sample, allowing for quantitative analysis.

There are several types of immunoassays, including enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), fluorescence immunoassay (FIA), and chemiluminescent immunoassay (CLIA). Each type has its own advantages and limitations, depending on the sensitivity, specificity, and throughput required for a particular application.

Nonparametric statistics is a branch of statistics that does not rely on assumptions about the distribution of variables in the population from which the sample is drawn. In contrast to parametric methods, nonparametric techniques make fewer assumptions about the data and are therefore more flexible in their application. Nonparametric tests are often used when the data do not meet the assumptions required for parametric tests, such as normality or equal variances.

Nonparametric statistical methods include tests such as the Wilcoxon rank-sum test (also known as the Mann-Whitney U test) for comparing two independent groups, the Wilcoxon signed-rank test for comparing two related groups, and the Kruskal-Wallis test for comparing more than two independent groups. These tests use the ranks of the data rather than the actual values to make comparisons, which allows them to be used with ordinal or continuous data that do not meet the assumptions of parametric tests.

Overall, nonparametric statistics provide a useful set of tools for analyzing data in situations where the assumptions of parametric methods are not met, and can help researchers draw valid conclusions from their data even when the data are not normally distributed or have other characteristics that violate the assumptions of parametric tests.

"Fundus Oculi" is a medical term that refers to the back part of the interior of the eye, including the optic disc, macula, fovea, retinal vasculature, and peripheral retina. It is the area where light is focused and then transmitted to the brain via the optic nerve, forming visual images. Examinations of the fundus oculi are crucial for detecting various eye conditions such as diabetic retinopathy, macular degeneration, glaucoma, and other retinal diseases. The examination is typically performed using an ophthalmoscope or a specialized camera called a retinal camera.

Radiographic image enhancement refers to the process of improving the quality and clarity of radiographic images, such as X-rays, CT scans, or MRI images, through various digital techniques. These techniques may include adjusting contrast, brightness, and sharpness, as well as removing noise and artifacts that can interfere with image interpretation.

The goal of radiographic image enhancement is to provide medical professionals with clearer and more detailed images, which can help in the diagnosis and treatment of medical conditions. This process may be performed using specialized software or hardware tools, and it requires a strong understanding of imaging techniques and the specific needs of medical professionals.

Bacteriological techniques refer to the various methods and procedures used in the laboratory for the cultivation, identification, and study of bacteria. These techniques are essential in fields such as medicine, biotechnology, and research. Here are some common bacteriological techniques:

1. **Sterilization**: This is a process that eliminates or kills all forms of life, including bacteria, viruses, fungi, and spores. Common sterilization methods include autoclaving (using steam under pressure), dry heat (in an oven), chemical sterilants, and radiation.

2. **Aseptic Technique**: This refers to practices used to prevent contamination of sterile materials or environments with microorganisms. It includes the use of sterile equipment, gloves, and lab coats, as well as techniques such as flaming, alcohol swabbing, and using aseptic transfer devices.

3. **Media Preparation**: This involves the preparation of nutrient-rich substances that support bacterial growth. There are various types of media, including solid (agar), liquid (broth), and semi-solid (e.g., stab agar). The choice of medium depends on the type of bacteria being cultured and the purpose of the investigation.

4. **Inoculation**: This is the process of introducing a bacterial culture into a medium. It can be done using a loop, swab, or needle. The inoculum should be taken from a pure culture to avoid contamination.

5. **Incubation**: After inoculation, the bacteria are allowed to grow under controlled conditions of temperature, humidity, and atmospheric composition. This process is called incubation.

6. **Staining and Microscopy**: Bacteria are too small to be seen with the naked eye. Therefore, they need to be stained and observed under a microscope. Gram staining is a common method used to differentiate between two major groups of bacteria based on their cell wall composition.

7. **Biochemical Tests**: These are tests used to identify specific bacterial species based on their biochemical characteristics, such as their ability to ferment certain sugars, produce particular enzymes, or resist certain antibiotics.

8. **Molecular Techniques**: Advanced techniques like PCR and DNA sequencing can provide more precise identification of bacteria. They can also be used for genetic analysis and epidemiological studies.

Remember, handling microorganisms requires careful attention to biosafety procedures to prevent accidental infection or environmental contamination.

Plethysmography is a non-invasive medical technique used to measure changes in volume or blood flow within an organ or body part, typically in the lungs or extremities. There are several types of plethysmography, including:

1. **Whole Body Plethysmography (WBP):** This type of plethysmography is used to assess lung function and volumes by measuring changes in pressure within a sealed chamber that contains the patient's entire body except for their head. The patient breathes normally while wearing a nose clip, allowing technicians to analyze respiratory patterns, airflow, and lung volume changes.
2. **Segmental or Local Plethysmography:** This technique measures volume or blood flow changes in specific body parts, such as the limbs or digits. It can help diagnose and monitor conditions affecting peripheral circulation, like deep vein thrombosis, arterial occlusive disease, or Raynaud's phenomenon.
3. **Impedance Plethysmography (IPG):** This non-invasive method uses electrical impedance to estimate changes in blood volume within an organ or body part. By applying a small electrical current and measuring the opposition to flow (impedance), technicians can determine variations in blood volume, which can help diagnose conditions like deep vein thrombosis or heart failure.
4. **Optical Plethysmography:** This technique uses light to measure changes in blood volume, typically in the skin or mucous membranes. By shining a light on the area and analyzing the reflected or transmitted light, technicians can detect variations in blood volume related to cardiac output, respiration, or other physiological factors.

Overall, plethysmography is an essential tool for diagnosing and monitoring various medical conditions affecting circulation, respiratory function, and organ volumes.

I'm sorry for any confusion, but "Moire Topography" is not a recognized term in medical literature or anatomy. Moiré refers to a pattern created when two grids or patterns are overlaid, resulting in a new pattern of alternating light and dark lines. This phenomenon can be seen in various fields such as physics, mathematics, and graphic design. However, it is not typically used in the context of medical definitions related to anatomy or pathology. If you have any other questions or need information on a different topic, please let me know!

Gated Blood-Pool Imaging (GBPI) is a type of nuclear medicine test that uses radioactive material and a specialized camera to create detailed images of the heart and its function. In this procedure, a small amount of radioactive tracer is injected into the patient's bloodstream, which then accumulates in the heart muscle and the blood pool within the heart chambers.

The term "gated" refers to the use of an electrocardiogram (ECG) signal to synchronize the image acquisition with the heart's contractions. This allows for the visualization of the heart's motion during different phases of the cardiac cycle, providing valuable information about the size, shape, and contraction of the heart chambers, as well as the movement of the walls of the heart.

GBPI is often used to assess patients with known or suspected heart disease, such as valvular abnormalities, cardiomyopathies, or congenital heart defects. It can help diagnose and evaluate the severity of these conditions, guide treatment decisions, and monitor the effectiveness of therapy.

Interferometry is not specifically a medical term, but it is used in certain medical fields such as ophthalmology and optics research. Here is a general definition:

Interferometry is a physical method that uses the interference of waves to measure the differences in phase between two or more waves. In other words, it's a technique that combines two or more light waves to create an interference pattern, which can then be analyzed to extract information about the properties of the light waves, such as their wavelength, amplitude, and phase.

In ophthalmology, interferometry is used in devices like wavefront sensors to measure the aberrations in the eye's optical system. By analyzing the interference pattern created by the light passing through the eye, these devices can provide detailed information about the shape and curvature of the cornea and lens, helping doctors to diagnose and treat various vision disorders.

In optics research, interferometry is used to study the properties of light waves and materials that interact with them. By analyzing the interference patterns created by light passing through different materials or devices, researchers can gain insights into their optical properties, such as their refractive index, thickness, and surface roughness.

Perfusion imaging is a medical imaging technique used to evaluate the blood flow or perfusion in various organs and tissues of the body. It is often utilized in conjunction with computed tomography (CT), magnetic resonance imaging (MRI), or single-photon emission computed tomography (SPECT) scans.

During a perfusion imaging procedure, a contrast agent is introduced into the patient's bloodstream, and a series of images are captured to track the flow and distribution of the contrast agent over time. This information helps medical professionals assess tissue viability, identify areas of reduced or blocked blood flow, and detect various pathological conditions such as stroke, heart attack, pulmonary embolism, and tumors.

In summary, perfusion imaging is a valuable diagnostic tool for evaluating the circulatory function of different organs and tissues in the body.

"Healthy volunteers" are individuals who are free from any disease or illness and are typically used as controls in clinical trials or research studies. They are often required to have normal or stable laboratory test results, no significant medical history, and meet certain age and physical fitness criteria. Their role is to provide a baseline for comparison with subjects who have the condition or disease being studied. It's important to note that while healthy volunteers may not have any known health issues at the time of the study, this does not guarantee they will remain in good health throughout the duration of the trial.

Computer-assisted diagnosis (CAD) is the use of computer systems to aid in the diagnostic process. It involves the use of advanced algorithms and data analysis techniques to analyze medical images, laboratory results, and other patient data to help healthcare professionals make more accurate and timely diagnoses. CAD systems can help identify patterns and anomalies that may be difficult for humans to detect, and they can provide second opinions and flag potential errors or uncertainties in the diagnostic process.

CAD systems are often used in conjunction with traditional diagnostic methods, such as physical examinations and patient interviews, to provide a more comprehensive assessment of a patient's health. They are commonly used in radiology, pathology, cardiology, and other medical specialties where imaging or laboratory tests play a key role in the diagnostic process.

While CAD systems can be very helpful in the diagnostic process, they are not infallible and should always be used as a tool to support, rather than replace, the expertise of trained healthcare professionals. It's important for medical professionals to use their clinical judgment and experience when interpreting CAD results and making final diagnoses.

Diagnostic errors refer to inaccurate or delayed diagnoses of a patient's medical condition, which can lead to improper or unnecessary treatment and potentially serious harm to the patient. These errors can occur due to various factors such as lack of clinical knowledge, failure to consider all possible diagnoses, inadequate communication between healthcare providers and patients, and problems with testing or interpretation of test results. Diagnostic errors are a significant cause of preventable harm in medical care and have been identified as a priority area for quality improvement efforts.

An exercise test, also known as a stress test or an exercise stress test, is a medical procedure used to evaluate the heart's function and response to physical exertion. It typically involves walking on a treadmill or pedaling a stationary bike while being monitored for changes in heart rate, blood pressure, electrocardiogram (ECG), and sometimes other variables such as oxygen consumption or gas exchange.

During the test, the patient's symptoms, such as chest pain or shortness of breath, are also closely monitored. The exercise test can help diagnose coronary artery disease, assess the severity of heart-related symptoms, and evaluate the effectiveness of treatments for heart conditions. It may also be used to determine a person's safe level of physical activity and fitness.

There are different types of exercise tests, including treadmill stress testing, stationary bike stress testing, nuclear stress testing, and stress echocardiography. The specific type of test used depends on the patient's medical history, symptoms, and overall health status.

A biological assay is a method used in biology and biochemistry to measure the concentration or potency of a substance (like a drug, hormone, or enzyme) by observing its effect on living cells or tissues. This type of assay can be performed using various techniques such as:

1. Cell-based assays: These involve measuring changes in cell behavior, growth, or viability after exposure to the substance being tested. Examples include proliferation assays, apoptosis assays, and cytotoxicity assays.
2. Protein-based assays: These focus on measuring the interaction between the substance and specific proteins, such as enzymes or receptors. Examples include enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and pull-down assays.
3. Genetic-based assays: These involve analyzing the effects of the substance on gene expression, DNA structure, or protein synthesis. Examples include quantitative polymerase chain reaction (qPCR) assays, reporter gene assays, and northern blotting.

Biological assays are essential tools in research, drug development, and diagnostic applications to understand biological processes and evaluate the potential therapeutic efficacy or toxicity of various substances.

Colorimetry is the scientific measurement and quantification of color, typically using a colorimeter or spectrophotometer. In the medical field, colorimetry may be used in various applications such as:

1. Diagnosis and monitoring of skin conditions: Colorimeters can measure changes in skin color to help diagnose or monitor conditions like jaundice, cyanosis, or vitiligo. They can also assess the effectiveness of treatments for these conditions.
2. Vision assessment: Colorimetry is used in vision testing to determine the presence and severity of visual impairments such as color blindness or deficiencies. Special tests called anomaloscopes or color vision charts are used to measure an individual's ability to distinguish between different colors.
3. Environmental monitoring: In healthcare settings, colorimetry can be employed to monitor the cleanliness and sterility of surfaces or equipment by measuring the amount of contamination present. This is often done using ATP (adenosine triphosphate) bioluminescence assays, which emit light when they come into contact with microorganisms.
4. Medical research: Colorimetry has applications in medical research, such as studying the optical properties of tissues or developing new diagnostic tools and techniques based on color measurements.

In summary, colorimetry is a valuable tool in various medical fields for diagnosis, monitoring, and research purposes. It allows healthcare professionals to make more informed decisions about patient care and treatment plans.

Emission-Computed Tomography, Single-Photon (SPECT) is a type of nuclear medicine imaging procedure that generates detailed, three-dimensional images of the distribution of radioactive pharmaceuticals within the body. It uses gamma rays emitted by a radiopharmaceutical that is introduced into the patient's body, and a specialized gamma camera to detect these gamma rays and create tomographic images. The data obtained from the SPECT imaging can be used to diagnose various medical conditions, evaluate organ function, and guide treatment decisions. It is commonly used to image the heart, brain, and bones, among other organs and systems.

Technetium Tc 99m Mertiatide is a radiopharmaceutical used in nuclear medicine imaging procedures. It is a technetium-labeled compound, where the radioisotope technetium-99m (^99m^Tc) is bound to mercaptoacetyltriglycine (MAG3). The resulting complex is known as ^99m^Tc-MAG3 or Technetium Tc 99m Mertiatide.

This radiopharmaceutical is primarily used for renal function assessment, including evaluation of kidney blood flow, glomerular filtration rate (GFR), and detection of renal obstructions or other abnormalities. After intravenous administration, Technetium Tc 99m Mertiatide is rapidly excreted by the kidneys, allowing for visualization and quantification of renal function through gamma camera imaging.

It's important to note that the use of radiopharmaceuticals should be performed under the guidance of a qualified healthcare professional, as they involve the administration of radioactive materials for diagnostic purposes.

Conductometry is a method used to measure the electrical conductivity of a solution, which can change in the presence of certain ions or chemical reactions. In conductometry, a conductivity probe or electrode is placed in the solution and an electrical current is passed through it. The resistance of the solution is then measured and converted into a measurement of conductivity.

Conductometry is often used to monitor chemical reactions that produce or consume ions, such as acid-base titrations, oxidation-reduction reactions, and complexation reactions. By measuring changes in conductivity over time, researchers can gain insights into the rate and extent of these reactions.

In medical research, conductometry may be used to study the electrical properties of biological tissues, such as skin or blood, or to monitor chemical processes in the body, such as the metabolism of drugs or other substances. However, it is not a commonly used diagnostic tool in clinical medicine.

A "false positive reaction" in medical testing refers to a situation where a diagnostic test incorrectly indicates the presence of a specific condition or disease in an individual who does not actually have it. This occurs when the test results give a positive outcome, while the true health status of the person is negative or free from the condition being tested for.

False positive reactions can be caused by various factors including:

1. Presence of unrelated substances that interfere with the test result (e.g., cross-reactivity between similar molecules).
2. Low specificity of the test, which means it may detect other conditions or irrelevant factors as positive.
3. Contamination during sample collection, storage, or analysis.
4. Human errors in performing or interpreting the test results.

False positive reactions can have significant consequences, such as unnecessary treatments, anxiety, and increased healthcare costs. Therefore, it is essential to confirm any positive test result with additional tests or clinical evaluations before making a definitive diagnosis.

Technetium Tc 99m Diethyl-iminodiacetic Acid (Tc 99m DTPA) is a radiopharmaceutical agent used in medical imaging. It is a technetium-labeled compound, where the radioisotope technetium-99m is bound to diethyl-iminodiacetic acid (DTPA). This complex is used as a renal agent for performing nuclear medicine imaging studies to assess kidney function and structure.

Technetium-99m is a metastable isotope of technetium that emits gamma rays, making it suitable for medical imaging. When Tc 99m DTPA is injected into the patient's body, it is excreted primarily by the kidneys through glomerular filtration and tubular secretion. The gamma rays emitted by technetium-99m are detected by a gamma camera, which generates images of the distribution and excretion of the radiopharmaceutical within the kidneys. This information helps physicians evaluate kidney function, detect abnormalities such as obstructions or tumors, and monitor the effectiveness of treatments.

It is essential to handle and administer Tc 99m DTPA with care due to its radioactive nature, following proper safety guidelines and regulations to ensure patient and staff safety.

I'm sorry for any confusion, but "Microcomputers" is not a term commonly used in medical definitions. Microcomputers are small computers with a microprocessor as the central processing unit. They are widely used in various settings, including healthcare, to perform tasks such as data management, analysis, and patient record keeping. However, the term itself does not have a specific medical connotation. If you have any questions related to technology use in healthcare, I'd be happy to try to help with those!

A breath test is a medical or forensic procedure used to analyze a sample of exhaled breath in order to detect and measure the presence of various substances, most commonly alcohol. The test is typically conducted using a device called a breathalyzer, which measures the amount of alcohol in the breath and converts it into a reading of blood alcohol concentration (BAC).

In addition to alcohol, breath tests can also be used to detect other substances such as drugs or volatile organic compounds (VOCs) that may indicate certain medical conditions. However, these types of breath tests are less common and may not be as reliable or accurate as other diagnostic tests.

Breath testing is commonly used by law enforcement officers to determine whether a driver is impaired by alcohol and to establish probable cause for arrest. It is also used in some healthcare settings to monitor patients who are being treated for alcohol abuse or dependence.

Emission computed tomography (ECT) is a type of tomographic imaging technique in which an emission signal from within the body is detected to create cross-sectional images of that signal's distribution. In Emission-Computed Tomography (ECT), a radionuclide is introduced into the body, usually through injection, inhalation or ingestion. The radionuclide emits gamma rays that are then detected by external gamma cameras.

The data collected from these cameras is then used to create cross-sectional images of the distribution of the radiopharmaceutical within the body. This allows for the identification and quantification of functional information about specific organs or systems within the body, such as blood flow, metabolic activity, or receptor density.

One common type of Emission-Computed Tomography is Single Photon Emission Computed Tomography (SPECT), which uses a single gamma camera that rotates around the patient to collect data from multiple angles. Another type is Positron Emission Tomography (PET), which uses positron-emitting radionuclides and detects the coincident gamma rays emitted by the annihilation of positrons and electrons.

Overall, ECT is a valuable tool in medical imaging for diagnosing and monitoring various diseases, including cancer, heart disease, and neurological disorders.

Indicators and reagents are terms commonly used in the field of clinical chemistry and laboratory medicine. Here are their definitions:

1. Indicator: An indicator is a substance that changes its color or other physical properties in response to a chemical change, such as a change in pH, oxidation-reduction potential, or the presence of a particular ion or molecule. Indicators are often used in laboratory tests to monitor or signal the progress of a reaction or to indicate the end point of a titration. A familiar example is the use of phenolphthalein as a pH indicator in acid-base titrations, which turns pink in basic solutions and colorless in acidic solutions.

2. Reagent: A reagent is a substance that is added to a system (such as a sample or a reaction mixture) to bring about a chemical reaction, test for the presence or absence of a particular component, or measure the concentration of a specific analyte. Reagents are typically chemicals with well-defined and consistent properties, allowing them to be used reliably in analytical procedures. Examples of reagents include enzymes, antibodies, dyes, metal ions, and organic compounds. In laboratory settings, reagents are often prepared and standardized according to strict protocols to ensure their quality and performance in diagnostic tests and research applications.

Statistical models are mathematical representations that describe the relationship between variables in a given dataset. They are used to analyze and interpret data in order to make predictions or test hypotheses about a population. In the context of medicine, statistical models can be used for various purposes such as:

1. Disease risk prediction: By analyzing demographic, clinical, and genetic data using statistical models, researchers can identify factors that contribute to an individual's risk of developing certain diseases. This information can then be used to develop personalized prevention strategies or early detection methods.

2. Clinical trial design and analysis: Statistical models are essential tools for designing and analyzing clinical trials. They help determine sample size, allocate participants to treatment groups, and assess the effectiveness and safety of interventions.

3. Epidemiological studies: Researchers use statistical models to investigate the distribution and determinants of health-related events in populations. This includes studying patterns of disease transmission, evaluating public health interventions, and estimating the burden of diseases.

4. Health services research: Statistical models are employed to analyze healthcare utilization, costs, and outcomes. This helps inform decisions about resource allocation, policy development, and quality improvement initiatives.

5. Biostatistics and bioinformatics: In these fields, statistical models are used to analyze large-scale molecular data (e.g., genomics, proteomics) to understand biological processes and identify potential therapeutic targets.

In summary, statistical models in medicine provide a framework for understanding complex relationships between variables and making informed decisions based on data-driven insights.

Ophthalmology is a branch of medicine that deals with the diagnosis, treatment, and prevention of diseases and disorders of the eye and visual system. It is a surgical specialty, and ophthalmologists are medical doctors who complete additional years of training to become experts in eye care. They are qualified to perform eye exams, diagnose and treat eye diseases, prescribe glasses and contact lenses, and perform eye surgery. Some subspecialties within ophthalmology include cornea and external disease, glaucoma, neuro-ophthalmology, pediatric ophthalmology, retina and vitreous, and oculoplastics.

Software validation, in the context of medical devices and healthcare, is the process of evaluating software to ensure that it meets specified requirements for its intended use and that it performs as expected. This process is typically carried out through testing and other verification methods to ensure that the software functions correctly, safely, and reliably in a real-world environment. The goal of software validation is to provide evidence that the software is fit for its intended purpose and complies with relevant regulations and standards. It is an important part of the overall process of bringing a medical device or healthcare technology to market, as it helps to ensure patient safety and regulatory compliance.

A physical examination is a methodical and systematic process of evaluating a patient's overall health status. It involves inspecting, palpating, percussing, and auscultating different parts of the body to detect any abnormalities or medical conditions. The primary purpose of a physical examination is to gather information about the patient's health, identify potential health risks, diagnose medical conditions, and develop an appropriate plan for prevention, treatment, or further evaluation.

During a physical examination, a healthcare provider may assess various aspects of a patient's health, including their vital signs (such as blood pressure, heart rate, temperature, and respiratory rate), height, weight, body mass index (BMI), and overall appearance. They may also examine different organ systems, such as the cardiovascular, respiratory, gastrointestinal, neurological, musculoskeletal, and genitourinary systems, to identify any signs of disease or abnormalities.

Physical examinations are an essential part of preventive healthcare and are typically performed during routine check-ups, annual physicals, and when patients present with symptoms or concerns about their health. The specific components of a physical examination may vary depending on the patient's age, sex, medical history, and presenting symptoms.

The anterior chamber is the front portion of the eye, located between the cornea (the clear front "window" of the eye) and the iris (the colored part of the eye). It is filled with a clear fluid called aqueous humor that provides nutrients to the structures inside the eye and helps maintain its shape. The anterior chamber plays an important role in maintaining the overall health and function of the eye.

Automatic Data Processing (ADP) is not a medical term, but a general business term that refers to the use of computers and software to automate and streamline administrative tasks and processes. In a medical context, ADP may be used in healthcare settings to manage electronic health records (EHRs), billing and coding, insurance claims processing, and other data-intensive tasks.

The goal of using ADP in healthcare is to improve efficiency, accuracy, and timeliness of administrative processes, while reducing costs and errors associated with manual data entry and management. By automating these tasks, healthcare providers can focus more on patient care and less on paperwork, ultimately improving the quality of care delivered to patients.

I'm sorry for any confusion, but "smiling" is not typically considered a medical term. It's a part of normal human behavior and facial expression. A smile usually refers to the action of turning up the corners of the mouth to signal pleasure, affection, amusement, or approval. However, in a medical context, a person may be unable to smile due to various conditions, such as facial paralysis caused by Bell's palsy or a stroke. In such cases, the ability to smile can be an important part of rehabilitation and recovery.

DNA fingerprinting, also known as DNA profiling or genetic fingerprinting, is a laboratory technique used to identify and compare the unique genetic makeup of individuals by analyzing specific regions of their DNA. This method is based on the variation in the length of repetitive sequences of DNA called variable number tandem repeats (VNTRs) or short tandem repeats (STRs), which are located at specific locations in the human genome and differ significantly among individuals, except in the case of identical twins.

The process of DNA fingerprinting involves extracting DNA from a sample, amplifying targeted regions using the polymerase chain reaction (PCR), and then separating and visualizing the resulting DNA fragments through electrophoresis. The fragment patterns are then compared to determine the likelihood of a match between two samples.

DNA fingerprinting has numerous applications in forensic science, paternity testing, identity verification, and genealogical research. It is considered an essential tool for providing strong evidence in criminal investigations and resolving disputes related to parentage and inheritance.

Gas Chromatography-Mass Spectrometry (GC-MS) is a powerful analytical technique that combines the separating power of gas chromatography with the identification capabilities of mass spectrometry. This method is used to separate, identify, and quantify different components in complex mixtures.

In GC-MS, the mixture is first vaporized and carried through a long, narrow column by an inert gas (carrier gas). The various components in the mixture interact differently with the stationary phase inside the column, leading to their separation based on their partition coefficients between the mobile and stationary phases. As each component elutes from the column, it is then introduced into the mass spectrometer for analysis.

The mass spectrometer ionizes the sample, breaks it down into smaller fragments, and measures the mass-to-charge ratio of these fragments. This information is used to generate a mass spectrum, which serves as a unique "fingerprint" for each compound. By comparing the generated mass spectra with reference libraries or known standards, analysts can identify and quantify the components present in the original mixture.

GC-MS has wide applications in various fields such as forensics, environmental analysis, drug testing, and research laboratories due to its high sensitivity, specificity, and ability to analyze volatile and semi-volatile compounds.

A laser is not a medical term per se, but a physical concept that has important applications in medicine. The term "LASER" stands for "Light Amplification by Stimulated Emission of Radiation." It refers to a device that produces and amplifies light with specific characteristics, such as monochromaticity (single wavelength), coherence (all waves moving in the same direction), and high intensity.

In medicine, lasers are used for various therapeutic and diagnostic purposes, including surgery, dermatology, ophthalmology, and dentistry. They can be used to cut, coagulate, or vaporize tissues with great precision, minimizing damage to surrounding structures. Additionally, lasers can be used to detect and measure physiological parameters, such as blood flow and oxygen saturation.

It's important to note that while lasers are powerful tools in medicine, they must be used by trained professionals to ensure safe and effective treatment.

Nucleic acid amplification techniques (NAATs) are medical laboratory methods used to increase the number of copies of a specific DNA or RNA sequence. These techniques are widely used in molecular biology and diagnostics, including the detection and diagnosis of infectious diseases, genetic disorders, and cancer.

The most commonly used NAAT is the polymerase chain reaction (PCR), which involves repeated cycles of heating and cooling to separate and replicate DNA strands. Other NAATs include loop-mediated isothermal amplification (LAMP), nucleic acid sequence-based amplification (NASBA), and transcription-mediated amplification (TMA).

NAATs offer several advantages over traditional culture methods for detecting pathogens, including faster turnaround times, increased sensitivity and specificity, and the ability to detect viable but non-culturable organisms. However, they also require specialized equipment and trained personnel, and there is a risk of contamination and false positive results if proper precautions are not taken.

Osteoarthritis (OA) of the knee is a degenerative joint disease that affects the articular cartilage and subchondral bone in the knee joint. It is characterized by the breakdown and eventual loss of the smooth, cushioning cartilage that covers the ends of bones and allows for easy movement within joints. As the cartilage wears away, the bones rub against each other, causing pain, stiffness, and limited mobility. Osteoarthritis of the knee can also lead to the formation of bone spurs (osteophytes) and cysts in the joint. This condition is most commonly found in older adults, but it can also occur in younger people as a result of injury or overuse. Risk factors include obesity, family history, previous joint injuries, and repetitive stress on the knee joint. Treatment options typically include pain management, physical therapy, and in some cases, surgery.

Radiographic magnification is a phenomenon that occurs during radiographic imaging where the image produced appears larger than the actual size of the object being imaged. This can occur due to several reasons, including the use of a focal distance that is shorter than the object-to-image receptor distance (SID), or when using a grid that is misaligned with the X-ray beam.

In some cases, radiographic magnification may be intentionally used as a technique to improve image quality for small structures or to enhance visualization of certain details in an image. However, it can also lead to distortion and decreased image sharpness if not properly controlled. Therefore, it is important to carefully consider the benefits and potential drawbacks of radiographic magnification when using this technique in medical imaging.

Cluster analysis is a statistical method used to group similar objects or data points together based on their characteristics or features. In medical and healthcare research, cluster analysis can be used to identify patterns or relationships within complex datasets, such as patient records or genetic information. This technique can help researchers to classify patients into distinct subgroups based on their symptoms, diagnoses, or other variables, which can inform more personalized treatment plans or public health interventions.

Cluster analysis involves several steps, including:

1. Data preparation: The researcher must first collect and clean the data, ensuring that it is complete and free from errors. This may involve removing outlier values or missing data points.
2. Distance measurement: Next, the researcher must determine how to measure the distance between each pair of data points. Common methods include Euclidean distance (the straight-line distance between two points) or Manhattan distance (the distance between two points along a grid).
3. Clustering algorithm: The researcher then applies a clustering algorithm, which groups similar data points together based on their distances from one another. Common algorithms include hierarchical clustering (which creates a tree-like structure of clusters) or k-means clustering (which assigns each data point to the nearest centroid).
4. Validation: Finally, the researcher must validate the results of the cluster analysis by evaluating the stability and robustness of the clusters. This may involve re-running the analysis with different distance measures or clustering algorithms, or comparing the results to external criteria.

Cluster analysis is a powerful tool for identifying patterns and relationships within complex datasets, but it requires careful consideration of the data preparation, distance measurement, and validation steps to ensure accurate and meaningful results.

Blood pressure determination is the medical procedure to measure and assess the force or pressure exerted by the blood on the walls of the arteries during a heartbeat cycle. It is typically measured in millimeters of mercury (mmHg) and is expressed as two numbers: systolic pressure (the higher number, representing the pressure when the heart beats and pushes blood out into the arteries) and diastolic pressure (the lower number, representing the pressure when the heart rests between beats). A normal blood pressure reading is typically around 120/80 mmHg. High blood pressure (hypertension) is defined as a consistently elevated blood pressure of 130/80 mmHg or higher, while low blood pressure (hypotension) is defined as a consistently low blood pressure below 90/60 mmHg. Blood pressure determination is an important vital sign and helps to evaluate overall cardiovascular health and identify potential health risks.

Molecular diagnostic techniques are a group of laboratory methods used to analyze biological markers in DNA, RNA, and proteins to identify specific health conditions or diseases at the molecular level. These techniques include various methods such as polymerase chain reaction (PCR), DNA sequencing, gene expression analysis, fluorescence in situ hybridization (FISH), and mass spectrometry.

Molecular diagnostic techniques are used to detect genetic mutations, chromosomal abnormalities, viral and bacterial infections, and other molecular changes associated with various diseases, including cancer, genetic disorders, infectious diseases, and neurological disorders. These techniques provide valuable information for disease diagnosis, prognosis, treatment planning, and monitoring of treatment response.

Compared to traditional diagnostic methods, molecular diagnostic techniques offer several advantages, such as higher sensitivity, specificity, and speed. They can detect small amounts of genetic material or proteins, even in early stages of the disease, and provide accurate results with a lower risk of false positives or negatives. Additionally, molecular diagnostic techniques can be automated, standardized, and performed in high-throughput formats, making them suitable for large-scale screening and research applications.

A single-blind method in medical research is a study design where the participants are unaware of the group or intervention they have been assigned to, but the researchers conducting the study know which participant belongs to which group. This is done to prevent bias from the participants' expectations or knowledge of their assignment, while still allowing the researchers to control the study conditions and collect data.

In a single-blind trial, the participants do not know whether they are receiving the active treatment or a placebo (a sham treatment that looks like the real thing but has no therapeutic effect), whereas the researcher knows which participant is receiving which intervention. This design helps to ensure that the participants' responses and outcomes are not influenced by their knowledge of the treatment assignment, while still allowing the researchers to assess the effectiveness or safety of the intervention being studied.

Single-blind methods are commonly used in clinical trials and other medical research studies where it is important to minimize bias and control for confounding variables that could affect the study results.

X-ray intensifying screens are medical imaging devices that contain phosphorescent materials, which emit light in response to the absorption of X-ray radiation. They are used in conjunction with X-ray film to enhance the visualization of radiographic images by converting X-rays into visible light. The screens are placed inside a cassette, along with the X-ray film, and exposed to X-rays during medical imaging procedures such as radiography or fluoroscopy.

The phosphorescent materials in the intensifying screens absorb most of the X-ray energy and re-emit it as visible light, which then exposes the X-ray film. This process increases the efficiency of the X-ray exposure, reducing the amount of radiation required to produce a diagnostic image. The use of intensifying screens can significantly improve the quality and detail of radiographic images while minimizing patient exposure to ionizing radiation.

Pulsatile flow is a type of fluid flow that occurs in a rhythmic, wave-like pattern, typically seen in the cardiovascular system. It refers to the periodic variation in the volume or velocity of a fluid (such as blood) that is caused by the regular beating of the heart. In pulsatile flow, there are periods of high flow followed by periods of low or no flow, which creates a distinct pattern on a graph or tracing. This type of flow is important for maintaining proper function and health in organs and tissues throughout the body.

Gonioscopy is a diagnostic procedure in ophthalmology used to examine the anterior chamber angle, which is the area where the iris and cornea meet. This examination helps to evaluate the drainage pathways of the eye for conditions such as glaucoma. A special contact lens called a goniolens is placed on the cornea during the procedure to allow the healthcare provider to visualize the angle using a biomicroscope. The lens may be coupled with a mirrored or prismatic surface to enhance the view of the angle. Gonioscopy can help detect conditions like narrow angles, closed angles, neovascularization, and other abnormalities that might contribute to glaucoma development or progression.

Intraocular pressure (IOP) is the fluid pressure within the eye, specifically within the anterior chamber, which is the space between the cornea and the iris. It is measured in millimeters of mercury (mmHg). The aqueous humor, a clear fluid that fills the anterior chamber, is constantly produced and drained, maintaining a balance that determines the IOP. Normal IOP ranges from 10-21 mmHg, with average values around 15-16 mmHg. Elevated IOP is a key risk factor for glaucoma, a group of eye conditions that can lead to optic nerve damage and vision loss if not treated promptly and effectively. Regular monitoring of IOP is essential in diagnosing and managing glaucoma and other ocular health issues.

Breast neoplasms refer to abnormal growths in the breast tissue that can be benign or malignant. Benign breast neoplasms are non-cancerous tumors or growths, while malignant breast neoplasms are cancerous tumors that can invade surrounding tissues and spread to other parts of the body.

Breast neoplasms can arise from different types of cells in the breast, including milk ducts, milk sacs (lobules), or connective tissue. The most common type of breast cancer is ductal carcinoma, which starts in the milk ducts and can spread to other parts of the breast and nearby structures.

Breast neoplasms are usually detected through screening methods such as mammography, ultrasound, or MRI, or through self-examination or clinical examination. Treatment options for breast neoplasms depend on several factors, including the type and stage of the tumor, the patient's age and overall health, and personal preferences. Treatment may include surgery, radiation therapy, chemotherapy, hormone therapy, or targeted therapy.

Photometry is the measurement and study of light, specifically its brightness or luminous intensity. In a medical context, photometry is often used in ophthalmology to describe diagnostic tests that measure the amount and type of light that is perceived by the eye. This can help doctors diagnose and monitor various eye conditions and diseases, such as cataracts, glaucoma, and retinal disorders. Photometry may also be used in other medical fields, such as dermatology, to evaluate the effects of different types of light on skin conditions.

A diet, in medical terms, refers to the planned and regular consumption of food and drinks. It is a balanced selection of nutrient-rich foods that an individual eats on a daily or periodic basis to meet their energy needs and maintain good health. A well-balanced diet typically includes a variety of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.

A diet may also be prescribed for therapeutic purposes, such as in the management of certain medical conditions like diabetes, hypertension, or obesity. In these cases, a healthcare professional may recommend specific restrictions or modifications to an individual's regular diet to help manage their condition and improve their overall health.

It is important to note that a healthy and balanced diet should be tailored to an individual's age, gender, body size, activity level, and any underlying medical conditions. Consulting with a healthcare professional, such as a registered dietitian or nutritionist, can help ensure that an individual's dietary needs are being met in a safe and effective way.

Diagnostic imaging is a medical specialty that uses various technologies to produce visual representations of the internal structures and functioning of the body. These images are used to diagnose injury, disease, or other abnormalities and to monitor the effectiveness of treatment. Common modalities of diagnostic imaging include:

1. Radiography (X-ray): Uses ionizing radiation to produce detailed images of bones, teeth, and some organs.
2. Computed Tomography (CT) Scan: Combines X-ray technology with computer processing to create cross-sectional images of the body.
3. Magnetic Resonance Imaging (MRI): Uses a strong magnetic field and radio waves to generate detailed images of soft tissues, organs, and bones.
4. Ultrasound: Employs high-frequency sound waves to produce real-time images of internal structures, often used for obstetrics and gynecology.
5. Nuclear Medicine: Involves the administration of radioactive tracers to assess organ function or detect abnormalities within the body.
6. Positron Emission Tomography (PET) Scan: Uses a small amount of radioactive material to produce detailed images of metabolic activity in the body, often used for cancer detection and monitoring treatment response.
7. Fluoroscopy: Utilizes continuous X-ray imaging to observe moving structures or processes within the body, such as swallowing studies or angiography.

Diagnostic imaging plays a crucial role in modern medicine, allowing healthcare providers to make informed decisions about patient care and treatment plans.

Paraffin embedding is a process in histology (the study of the microscopic structure of tissues) where tissue samples are impregnated with paraffin wax to create a solid, stable block. This allows for thin, uniform sections of the tissue to be cut and mounted on slides for further examination under a microscope.

The process involves fixing the tissue sample with a chemical fixative to preserve its structure, dehydrating it through a series of increasing concentrations of alcohol, clearing it in a solvent such as xylene to remove the alcohol, and then impregnating it with melted paraffin wax. The tissue is then cooled and hardened into a block, which can be stored, transported, and sectioned as needed.

Paraffin embedding is a commonly used technique in histology due to its relative simplicity, low cost, and ability to produce high-quality sections for microscopic examination.

Microbial sensitivity tests, also known as antibiotic susceptibility tests (ASTs) or bacterial susceptibility tests, are laboratory procedures used to determine the effectiveness of various antimicrobial agents against specific microorganisms isolated from a patient's infection. These tests help healthcare providers identify which antibiotics will be most effective in treating an infection and which ones should be avoided due to resistance. The results of these tests can guide appropriate antibiotic therapy, minimize the potential for antibiotic resistance, improve clinical outcomes, and reduce unnecessary side effects or toxicity from ineffective antimicrobials.

There are several methods for performing microbial sensitivity tests, including:

1. Disk diffusion method (Kirby-Bauer test): A standardized paper disk containing a predetermined amount of an antibiotic is placed on an agar plate that has been inoculated with the isolated microorganism. After incubation, the zone of inhibition around the disk is measured to determine the susceptibility or resistance of the organism to that particular antibiotic.
2. Broth dilution method: A series of tubes or wells containing decreasing concentrations of an antimicrobial agent are inoculated with a standardized microbial suspension. After incubation, the minimum inhibitory concentration (MIC) is determined by observing the lowest concentration of the antibiotic that prevents visible growth of the organism.
3. Automated systems: These use sophisticated technology to perform both disk diffusion and broth dilution methods automatically, providing rapid and accurate results for a wide range of microorganisms and antimicrobial agents.

The interpretation of microbial sensitivity test results should be done cautiously, considering factors such as the site of infection, pharmacokinetics and pharmacodynamics of the antibiotic, potential toxicity, and local resistance patterns. Regular monitoring of susceptibility patterns and ongoing antimicrobial stewardship programs are essential to ensure optimal use of these tests and to minimize the development of antibiotic resistance.

Protein array analysis is a high-throughput technology used to detect and measure the presence and activity of specific proteins in biological samples. This technique utilizes arrays or chips containing various capture agents, such as antibodies or aptamers, that are designed to bind to specific target proteins. The sample is then added to the array, allowing the target proteins to bind to their corresponding capture agents. After washing away unbound materials, a detection system is used to identify and quantify the bound proteins. This method can be used for various applications, including protein-protein interaction studies, biomarker discovery, and drug development. The results of protein array analysis provide valuable information about the expression levels, post-translational modifications, and functional states of proteins in complex biological systems.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

Tissue fixation is a process in histology (the study of the microscopic structure of tissues) where fixed tissue samples are prepared for further examination, typically through microscopy. The goal of tissue fixation is to preserve the original three-dimensional structure and biochemical composition of tissues and cells as much as possible, making them stable and suitable for various analyses.

The most common method for tissue fixation involves immersing the sample in a chemical fixative, such as formaldehyde or glutaraldehyde. These fixatives cross-link proteins within the tissue, creating a stable matrix that maintains the original structure and prevents decay. Other methods of tissue fixation may include freezing or embedding samples in various media to preserve their integrity.

Properly fixed tissue samples can be sectioned, stained, and examined under a microscope, allowing pathologists and researchers to study cellular structures, diagnose diseases, and understand biological processes at the molecular level.

The proteome is the entire set of proteins produced or present in an organism, system, organ, or cell at a certain time under specific conditions. It is a dynamic collection of protein species that changes over time, responding to various internal and external stimuli such as disease, stress, or environmental factors. The study of the proteome, known as proteomics, involves the identification and quantification of these protein components and their post-translational modifications, providing valuable insights into biological processes, functional pathways, and disease mechanisms.

Immobilized enzymes refer to enzymes that have been restricted or fixed in a specific location and are unable to move freely. This is typically achieved through physical or chemical methods that attach the enzyme to a solid support or matrix. The immobilization of enzymes can provide several advantages, including increased stability, reusability, and ease of separation from the reaction mixture.

Immobilized enzymes are widely used in various industrial applications, such as biotransformations, biosensors, and diagnostic kits. They can also be used for the production of pharmaceuticals, food additives, and other fine chemicals. The immobilization techniques include adsorption, covalent binding, entrapment, and cross-linking.

Adsorption involves physically attaching the enzyme to a solid support through weak forces such as van der Waals interactions or hydrogen bonding. Covalent binding involves forming chemical bonds between the enzyme and the support matrix. Entrapment involves encapsulating the enzyme within a porous matrix, while cross-linking involves chemically linking multiple enzyme molecules together to form a stable structure.

Overall, immobilized enzymes offer several advantages over free enzymes, including improved stability, reusability, and ease of separation from the reaction mixture, making them valuable tools in various industrial applications.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

Cardiac-gated imaging techniques are medical diagnostic procedures that involve synchronizing the acquisition of data with the electrical activity of the heart, typically the R-wave of the electrocardiogram (ECG). This allows for the capture of images during specific phases of the cardiac cycle, reducing motion artifacts and improving image quality. These techniques are commonly used in various imaging modalities such as echocardiography, cardiac magnetic resonance imaging (MRI), and nuclear medicine studies like myocardial perfusion imaging. By obtaining images at specific points in the cardiac cycle, these techniques help assess heart function, wall motion abnormalities, valve function, and myocardial perfusion, ultimately aiding in the diagnosis and management of various cardiovascular diseases.

A case-control study is an observational research design used to identify risk factors or causes of a disease or health outcome. In this type of study, individuals with the disease or condition (cases) are compared with similar individuals who do not have the disease or condition (controls). The exposure history or other characteristics of interest are then compared between the two groups to determine if there is an association between the exposure and the disease.

Case-control studies are often used when it is not feasible or ethical to conduct a randomized controlled trial, as they can provide valuable insights into potential causes of diseases or health outcomes in a relatively short period of time and at a lower cost than other study designs. However, because case-control studies rely on retrospective data collection, they are subject to biases such as recall bias and selection bias, which can affect the validity of the results. Therefore, it is important to carefully design and conduct case-control studies to minimize these potential sources of bias.

Dental instruments are specialized tools that dentists, dental hygienists, and other oral healthcare professionals use to examine, clean, and treat teeth and gums. These instruments come in various shapes and sizes, and each one is designed for a specific purpose. Here are some common dental instruments and their functions:

1. Mouth mirror: A small, handheld mirror used to help the dentist see hard-to-reach areas of the mouth and reflect light onto the teeth and gums.
2. Explorer: A sharp, hooked instrument used to probe teeth and detect cavities, tartar, or other dental problems.
3. Sickle scaler: A curved, sharp-edged instrument used to remove calculus (tartar) from the tooth surface.
4. Periodontal probe: A blunt, calibrated instrument used to measure the depth of periodontal pockets and assess gum health.
5. Dental syringe: A device used to inject local anesthesia into the gums before dental procedures.
6. High-speed handpiece: Also known as a dental drill, it is used to remove decay, shape teeth, or prepare them for fillings and other restorations.
7. Low-speed handpiece: A slower, quieter drill used for various procedures, such as placing crowns or veneers.
8. Suction tip: A thin tube that removes saliva, water, and debris from the mouth during dental procedures.
9. Cotton rolls: Small squares of cotton used to isolate teeth, absorb fluids, and protect soft tissues during dental treatments.
10. Dental forceps: Specialized pliers used to remove teeth or hold them in place while restorations are being placed.
11. Elevators: Curved, wedge-shaped instruments used to loosen or lift teeth out of their sockets.
12. Rubber dam: A thin sheet of rubber or latex that isolates a specific tooth or area during dental treatment, keeping it dry and free from saliva and debris.

These are just a few examples of the many dental instruments used in modern dentistry. Each one plays an essential role in maintaining oral health and providing effective dental care.

Dental photography is a type of clinical photography that focuses on documenting the condition and treatment of teeth and oral structures. It involves using specialized cameras, lenses, and lighting to capture high-quality images of the mouth and related areas. These images can be used for diagnostic purposes, patient education, treatment planning, communication with other dental professionals, and monitoring progress over time. Dental photography may include various types of shots, such as extraoral (outside the mouth) and intraoral (inside the mouth) views, close-ups of individual teeth or restorations, and full-face portraits. It requires a strong understanding of dental anatomy, lighting techniques, and image composition to produce accurate and informative images.

I apologize, but "Brazil" is not a medical term or condition. It is the largest country in both South America and Latin America by land area and population. If you have any questions related to medical terminology or health concerns, please provide more information and I will do my best to help.

The mandible, also known as the lower jaw, is the largest and strongest bone in the human face. It forms the lower portion of the oral cavity and plays a crucial role in various functions such as mastication (chewing), speaking, and swallowing. The mandible is a U-shaped bone that consists of a horizontal part called the body and two vertical parts called rami.

The mandible articulates with the skull at the temporomandibular joints (TMJs) located in front of each ear, allowing for movements like opening and closing the mouth, protrusion, retraction, and side-to-side movement. The mandible contains the lower teeth sockets called alveolar processes, which hold the lower teeth in place.

In medical terminology, the term "mandible" refers specifically to this bone and its associated structures.

Perinatology is a subspecialty of maternal-fetal medicine in obstetrics that focuses on the care of pregnant women and their unborn babies who are at high risk for complications due to various factors such as prematurity, fetal growth restriction, multiple gestations, congenital anomalies, and other medical conditions.

Perinatologists are trained to provide specialized care for these high-risk pregnancies, which may include advanced diagnostic testing, fetal monitoring, and interventions such as c-sections or medication management. They work closely with obstetricians, pediatricians, and other healthcare providers to ensure the best possible outcomes for both the mother and the baby.

Perinatology is also sometimes referred to as "maternal-fetal medicine" or "high-risk obstetrics."

Cyclopentolate is a medication that belongs to a class of drugs called anticholinergics. It is primarily used as an eye drop to dilate the pupils and prevent the muscles in the eye from focusing, which can help doctors to examine the back of the eye more thoroughly.

The medical definition of Cyclopentolate is:

A cycloplegic and mydriatic agent that is used topically to produce pupillary dilation and cyclospasm, and to paralyze accommodation. It is used in the diagnosis and treatment of various ocular conditions, including refractive errors, corneal injuries, and uveitis. The drug works by blocking the action of acetylcholine, a neurotransmitter that is involved in the regulation of pupil size and focus.

Cyclopentolate is available as an eye drop solution, typically at concentrations of 0.5% or 1%. It is usually administered one to two times, with the second dose given after about 5 to 10 minutes. The effects of the drug can last for several hours, depending on the dosage and individual patient factors.

While cyclopentolate is generally considered safe when used as directed, it can cause side effects such as stinging or burning upon instillation, blurred vision, photophobia (sensitivity to light), and dry mouth. In rare cases, more serious side effects such as confusion, agitation, or hallucinations may occur, particularly in children or older adults. It is important to follow the instructions of a healthcare provider when using cyclopentolate, and to report any unusual symptoms or side effects promptly.

Fluorine radioisotopes are radioactive isotopes or variants of the chemical element Fluorine (F, atomic number 9). These radioisotopes have an unstable nucleus that emits radiation in the form of alpha particles, beta particles, or gamma rays. Examples of Fluorine radioisotopes include Fluorine-18 and Fluorine-19.

Fluorine-18 is a positron-emitting radionuclide with a half-life of approximately 110 minutes, making it useful for medical imaging techniques such as Positron Emission Tomography (PET) scans. It is commonly used in the production of fluorodeoxyglucose (FDG), a radiopharmaceutical that can be used to detect cancer and other metabolic disorders.

Fluorine-19, on the other hand, is a stable isotope of Fluorine and does not emit radiation. However, it can be enriched and used as a non-radioactive tracer in medical research and diagnostic applications.

Dental caries activity tests are a group of diagnostic procedures used to measure or evaluate the activity and progression of dental caries (tooth decay). These tests help dentists and dental professionals determine the most appropriate treatment plan for their patients. Here are some commonly used dental caries activity tests:

1. **Bacterial Counts:** This test measures the number of bacteria present in a sample taken from the tooth surface. A higher bacterial count indicates a higher risk of dental caries.
2. **Sucrose Challenge Test:** In this test, a small amount of sucrose (table sugar) is applied to the tooth surface. After a set period, the presence and quantity of acid produced by bacteria are measured. Increased acid production suggests a higher risk of dental caries.
3. **pH Monitoring:** This test measures the acidity or alkalinity (pH level) of the saliva or plaque in the mouth. A lower pH level indicates increased acidity, which can lead to tooth decay.
4. **Dye Tests:** These tests use a special dye that stains active carious lesions on the tooth surface. The stained areas are then easily visible and can be evaluated for treatment.
5. **Transillumination Test:** A bright light is shone through the tooth to reveal any cracks, fractures, or areas of decay. This test helps identify early stages of dental caries that may not yet be visible during a routine dental examination.
6. **Laser Fluorescence Tests:** These tests use a handheld device that emits a laser beam to detect and quantify the presence of bacterial biofilm or dental plaque on the tooth surface. Increased fluorescence suggests a higher risk of dental caries.

It is important to note that these tests should be used as part of a comprehensive dental examination and not as standalone diagnostic tools. A dentist's clinical judgment, in conjunction with these tests, will help determine the best course of treatment for each individual patient.

The results of the Reproducibility Project might also affect public trust in psychology. Lay people who learned about the low ... The results of this collaboration were published in August 2015. Reproducibility is the ability to produce the same findings, ... "Reproducibility Project: Cancer Biology". www.cos.io. Center for Open Science. Retrieved 19 January 2022. Apple, Sam (22 ... The Reproducibility Project: Psychology was a crowdsourced collaboration of 270 contributing authors to repeat 100 published ...
In recent decades, there has been a rising concern that many published scientific results fail the test of reproducibility, ... With a narrower scope, reproducibility has been introduced in computational sciences: Any results should be documented by ... reproducibility - or is it the other way round?". Retrieved 2020-10-15. "IUPAC - reproducibility (R05305)". International Union ... evoking a reproducibility or replication crisis. The first to stress the importance of reproducibility in science was the Irish ...
JPSP is one of the journals analyzed in the Open Science Collaboration's Reproducibility Project after JPSP's publication of ... "How replicable are statistically significant results in social psychology? A replication and extension of Motyl et al. (in ... Open Science Collaboration (28 August 2015). "Estimating the reproducibility of psychological science". Science. 349 (6251): ... maintain the impression that research that is published in JPSP has been thoroughly vetted and is less likely to be the result ...
The results of the analysis should be the subject of the presentation. The clear documentation should provide reproducibility. ... As a result, some data may be destroyed after a legal hold has been issued by unknowing technicians performing their regular ... This resulted in significant sanctions against UBS. To establish authenticity, some archiving systems apply a unique code to ... Improper management of ESI can result in a finding of spoliation of evidence and the imposition of one or more sanctions, ...
Reproducibility and recovery). In order to ensure maximum reproducibility in gel pore size and to obtain a fully polymerized ... As a result, the prepared gel is homogeneous (in terms of homogeneous distribution of cross-links throughout the gel sample), ... forming covalent acrylamide adduction products that may result in multiple bands. Additionally, the time of polymerization of a ...
Woolston, Chris (October 29, 2014). "A blueprint to boost reproducibility of results". Nature. doi:10.1038/nature.2014.16222. ... He has led or co-led efforts to define and improve reproducibility in science, e.g. computational reproducibility, and to ... "PLOS ONE: Search Results". journals.plos.org. Archived from the original on February 18, 2022. Retrieved February 18, 2022. ... "Reproducibility in research: taming a "complex beast"". Elsevier Connect. Archived from the original on March 22, 2022. ...
Junk, Thomas; Lyons, Louis (2020-12-21). "Reproducibility and Replication of Experimental Particle Physics Results". Harvard ... More statistically significant results cannot be mere statistical flukes but can still result from experimental error or ... results from a BaBar experiment may suggest a surplus over Standard Model predictions of a type of particle decay ( B → D(*) τ ... Initial results from Fermilab's Muon g-2 experiment with a discrepancy of 4.2 standard deviations (σ) "strengthen evidence of ...
The different faces result in different growth rates and electronic properties. On the SiC(0001) face, large-area single ... These graphene layers do have a good reproducibility. In this case, the graphene layer grows not directly on top of the ... Using this technique, the resulting graphene consists of small grains with varying thickness (30-200 nm). These grains occur ... Because of their different possible orientations, sizes and thickness, the resulting graphene film contains misoriented grains ...
"Codecheck confirms reproducibility of COVID-19 model results". Mirage News. 2 June 2020. Retrieved 6 June 2020. Eglen SJ (29 ... Scheuber A, van Elsland SL (June 2020). "Codecheck confirms reproducibility of COVID-19 model results". Imperial News. Imperial ... The results obtained by Imperial using the model are consistent with other models that make similar assumptions. Calibration of ... A June 2020 editorial in Nature declared the original CovidSim codebase met the requirements of scientific reproducibility. ...
Part 1: reproducibility of results for the international intercomparison". Limnology and Oceanography: Methods. 10 (4): 234-251 ... Part of the Geotraces program is to ensure results for trace elements and isotopes collected on different cruises by different ...
The result was greatly increased reproducibility for antihydrogen production. In particular, this technique, dubbed SDREVC ( ... The result is a rotating electric field perpendicular to the axis of symmetry of the plasma. This field induces an electric ... Enhanced Control and Reproducibility of Non-Neutral Plasmas, Phys. Rev. Lett. 120, 025001 (2018). C. Amole, M. D. Ashkezari, M ... application of a rotating electric field at frequency results in the plasma spinning up to the applied frequency, namely fE = ...
The results are delivered through interactive and configurable interface. Results can be downloaded as publication ready ... All past releases are maintained for reproducibility and transparency. g:Profiler is freely available for all users at https:// ... MOET also displays the corresponding Bonferroni correction and odds ratio on the results page. It is simple to use, and results ... One base change has the potential to affect the protein that results from that gene being expressed; however, it also has the ...
A concern of Fiedler is the credibility gap of contemporary research manifesting itself in a lack of reproducible results; he ... is asking for scientific standards to demonstrate reproducibility. 2000, Leibniz Prize of the German Research Foundation (GRF) ...
Open research computation also addresses the problem of reproducibility of scientific results. The term "open science" does not ... Union, Publications Office of the European (2020). Reproducibility of scientific results in the EU : scoping report. ISBN 978- ... The resulting declaration calls for the use of digital tools such as open archives and open access journals, free of charge for ... "Reproducibility Project: Cancer Biology". www.cos.io. Center for Open Science. Retrieved 19 January 2022. Couchman, John R. (1 ...
"Search Results". PubMed.gov. Retrieved 17 December 2012. Carl Zimmer (August 14, 2012). "Good Scientist! You Get a Badge". ... "Reproducibility Initiative to Increase the Value of Biomedical Research". Bio IT World. August 17, 2012. Retrieved December 27 ... Iorns has been a longtime spokesperson on the issue of reproducibility in academic research. In August 2012 she helped launch ... for her role in launching the Reproducibility Initiative. In May 2013, Iorns was named, along with co-founders Ryan Abbott and ...
November 2010). "Reproducibility of interictal EEG-fMRI results in patients with epilepsy". Epilepsia. 52 (3): 433-442. doi: ... which automatically identifies noise components and results in a more thorough "scrubbing" of the BCG noise In principle, the ...
Reproducibility of experimental results is central to the scientific method. A standard system of units facilitates this. ... As a result, units of measure could vary not only from location to location but from person to person. Units not based on the ... When two different units are multiplied or divided, the result is a new unit, referred to by the combination of the units. For ... This accident was the result of both confusion due to the simultaneous use of metric and Imperial measures and confusion of ...
WBA strives to ensure objectivity, falsifiability and reproducibility of results. The result of a WBA is a why-because graph ( ... This process can be iterated for the newfound causes, and so on, until a satisfactory result has been achieved. At each node ( ...
They conclude "the main limitation...is the problem of reproducibility and lack of consistent results.". Various experimenters ... The resulting effects on crop growth depend nonspecifically upon multiple factors, including effects of the introduced EM ... Mayer, J.; Scheid, S.; Widmer, F.; Fließbach, A.; Oberholzer (2010). ""Effective microorganisms® (EM)"? Results from a field ...
Method and Data Sharing and Reproducibility of Scientific Results". Journal of Chemical Information and Modeling. 60 (12): 5868 ...
As a result of her interests, by age 20, Pockels devised a slide trough for making quantitative measurements on the surface ... She recognized that impurities can affect reproducibility of experimental findings. Pockels developed a refined method of ... Pockels pointed out that even airborne dust can affect results with her experimental apparatus. ... who with very homely appliances has arrived at valuable results respecting the behaviour of contaminated water surfaces. The ...
For instance, it has been shown that results of offline evaluations have low correlation with results from user studies or A/B ... find a common understanding of reproducibility, (3) identify and understand the determinants that affect reproducibility, (4) ... The topic of reproducibility seems to be a recurrent issue in some Machine Learning publication venues, but does not have a ... As a result, in December 2009, an anonymous Netflix user sued Netflix in Doe v. Netflix, alleging that Netflix had violated ...
Reproducibility has been defined as the ability of a result to be replicated through independent experiments within the same or ... These concerns are part of the larger reproducibility crisis in science. Some of the reasons for the lack of reproducibility in ... Erasmus Darwin was also impacted by the tragedy of the plagues and it resulted in the publication of his Zoonomia where he ... This resulted in several persistent misunderstandings of human anatomy. Another key early contributor to early comparative ...
With a view to improving reproducibility of scientific results, it has been suggested that research-funding agencies finance ... He counselled pursuing results with p values below 0.05 and not wasting time on results above that. Thus arose the idea that a ... A fundamental feature of the scientific enterprise is reproducibility of results. "For decades", writes Shannon Palus, "it has ... "These results," writes Oreskes, "parallel those of a 2018 study. An analysis of 126,000 rumor cascades on Twitter showed that ...
The data and analysis provenance is maintained for reproducibility of results. BisQue can be easily deployed in cloud computing ... These results are stored back into the system in the form of tags, graphical objects and/or images. Images or metadata are ... In the latter case, BisQue can automatically parallelize analysis over large image datasets and then collect the results in a ... In BisQue, sharing images, metadata and analysis results can be performed through the web. The system contains an export ...
Once the result is obtained it may be de-normalised to obtain the actual result. Using transmission-line theory, if a ... He felt it would have distinct advantages, particularly as regards reproducibility. With this in mind, he spoke to two of his ... The result gives λ = 375 m m {\displaystyle \lambda =375\ \mathrm {mm} \,} , making the position of the matching component 29.6 ... Thus most RF circuit analysis software includes a Smith chart option for the display of results and all but the simplest ...
Piette, Elizabeth R.; Moore, Jason H. (19 April 2017). "Improving the Reproducibility of Genetic Association Results Using ... Permutation testing makes it possible to generate an empirical p-value for the result. Replication in independent data may also ...
Research incorporating sex as a biological variable increases the rigor and reproducibility of results. After publishing the ... In 2001, they presented a report that sex is an important variable in designing studies and assessing results. The quality and ... To improve the rigor and reproducibility of research findings, the European Commission, Canadian Institutes of Health Research ... Research including SABV has strengthened the rigor and reproducibility of findings. Public research institutions including the ...
But when he finally presented his results he reported an excess heat of only one degree Celsius, a result that could be ... Reproducibility is one of the main principles of the scientific method, and its lack led most physicists to believe that the ... xi, 207-209 "The ratio of the worldwide positive results on cold fusion to negative results peaked at approximately 50% (...) ... concluding that results as of that date did not present convincing evidence that useful sources of energy would result from the ...
Frequently the symptom is a failure of the product or process to produce any results. (Nothing was printed, for example). ... Often considerable effort and emphasis in troubleshooting is placed on reproducibility ... on finding a procedure to reliably ... In electronics this often is the result of components that are thermally sensitive (since resistance of a circuit varies with ... However, many problems only occur as a result of multiple failures or errors. This is particularly true of fault tolerant ...
First clinical results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during ... First clinical results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during ... Results Out of 814 IWA measurement attempts, 462 WFMs could be obtained. The most successful readings (n=63) were achieved in ... Conclusions This is the first report addressing quality and reproducibility of WA in a large sample. IWA refraction in aphakia ...
Results. We identified 163 articles that reported 165 RCTs; 73 (44%) RCTs were registered, of which only 25 (15%) were ... Improving Transparency and Reproducibility Through Registration. The Status of Intervention Trials Published in Clinical ... Clinical psychology journals could improve transparency and reproducibility, as well as reduce bias, by requiring complete ...
The Reproducibility of Patient Self-reported Joint Counts in Rheumatoid Arthritis: A Closer Look at the Results of a Review. ... The Reproducibility of Patient Self-reported Joint Counts in Rheumatoid Arthritis: A Closer Look at the Results of a Review ... The Reproducibility of Patient Self-reported Joint Counts in Rheumatoid Arthritis: A Closer Look at the Results of a Review ... The Reproducibility of Patient Self-reported Joint Counts in Rheumatoid Arthritis: A Closer Look at the Results of a Review ...
The results obtained clearly demonstrate that comparability of community profiles established using different primer pairs is ... Overall our results indicate a rather limited comparability between community structures investigated and determined using ... does not necessarily reflect the results obtained in experimental approaches. In the latter, archaeal primer pair ArchV34 ... does not necessarily reflect the results obtained in experimental approaches. In the latter, archaeal primer pair ArchV34 ...
Similar results were found in the HERITAGE, ICQC, and TCQC data regarding the ICC values. For the most part, the results were ... Table 3 contains the results from the ICQC substudy on 55 subjects. There were similar results across the four trials, with the ... The reproducibility of V̇O2max in data from HERITAGE (Table 2), from the ICQC substudy (Table 3) and from the TCQC substudy ( ... Reproducibility of maximal exercise test data in the HERITAGE Family Study : Medicine & Science in Sports & Exercise. ...
Results: In the patient study, 75 patients, 25 in each group, were enrolled. The reproducibility of Grp2 (mean ± SD, 0.35 ± ... BSI reproducibility data for each predefined groups are detailed in Figure 2 and Table 3. The BSI reproducibility data of Grp2 ... RESULTS. Patient Study. Seventy-five patients with skeletal metastasis (BSI: mean, 0.61; IQR, 0.20-3.15) were enrolled in the ... The results of the simulation study independently verified the findings of the patient study, as the automated BSI values at ...
These results are similar to those reported for previous reproducibility studies of SUV measurements. The reproducibility of ... All reproducibility results using the Bland-Altman analysis, including lower and upper reproducibility limits (and associated ... of the same size as samples in previously published reproducibility studies (9-11). Although our reproducibility results were ... Results: The reproducibility of maximum and mean SUV was similar to that in previously reported studies, with a mean percentage ...
RESULTS. Phantom flow reproducibility. There was close agreement between the peak phantom flow and Doppler volumetric ... To ascertain the interobserver and intraobserver reproducibility, two observers (AKS and STK) blinded to each others results ... The reproducibility of any Doppler measurement is important, and we have shown that this measurement has good reproducibility ... Intraobserver reproducibility was assessed between two observations by the same observer. Interobserver reproducibility was ...
Pioneering live-code article allows scientists to play with each others results ... An ambitious project to test the reproducibility of biomedical experiments by Brazilian scientists is about to get under way. ... Brazilian biomedical science faces reproducibility test. Researchers at more than 60 Brazilian labs will assess the ... Pioneering live-code article allows scientists to play with each others results ...
New reporting standards for Nature journal authors are intended to improve transparency and reproducibility. ... checklist focuses on experimental and analytical design elements that are critical for the interpretation of research results ... Enhancing reproducibility. Nature Methods volume 10, page 367 (2013)Cite this article ... Improved reproducibility by assuring confidence in measurements in biomedical research *Anne L Plant ...
The CPSS has excellent reproducibility among prehospital personnel and physicians. It has good validity in identifying patients ... Results: A total of 860 scales were completed on a convenience sample of 171 patients from the emergency department and ... Cincinnati Prehospital Stroke Scale: reproducibility and validity Ann Emerg Med. 1999 Apr;33(4):373-8. doi: 10.1016/s0196-0644( ... The objective of this study was to validate and verify the reproducibility of the CPSS when used by prehospital providers. ...
... giving false positive results. Both intraobserver and interobserver reproducibility by QPRODIT 5.2 were good. With QPRODIT, ... While intraobserver reproducibility of both Ki-67 LI and area% was good (r = .96, r = .99), interobserver reproducibility of Ki ... Reproducibility of p53 and Ki-67 immunoquantitation in Barretts esophagus Anal Quant Cytol Histol. 1997 Jun;19(3):246-54. ... Results: Quantitation of p53 immunohistochemistry (IHC) by CAS was very reproducible by the same observer (r = .99), but its ...
The results of the Reproducibility Project might also affect public trust in psychology. Lay people who learned about the low ... The results of this collaboration were published in August 2015. Reproducibility is the ability to produce the same findings, ... "Reproducibility Project: Cancer Biology". www.cos.io. Center for Open Science. Retrieved 19 January 2022. Apple, Sam (22 ... The Reproducibility Project: Psychology was a crowdsourced collaboration of 270 contributing authors to repeat 100 published ...
Full reproducibility will be only achieved if an independent third party confirms that the results of the analytical processes ... Reproducibility of scientific research is an essential principle within science. Scientific results should stand the scrutiny ... The database is used to store the results of all the quality control processes performed with a timestamp of their result. It ... Upon receiving the results from a specific quality process, the server displays the quality report (success/ error message) to ...
New Results Vendor-neutral sequences and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI. ... Vendor-neutral sequences and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI ... Vendor-neutral sequences and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI ... Vendor-neutral sequences and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI ...
A recent roundtable discussion identifies challenges facing the scientific community regarding a lack of reproducible results ... DOROTHEUMThe gold standard for science is reproducibility. Ideally, research results are only worthy of attention, publication ... But for much of the scientific literature, results arent reproducible at all. The causes and remedies for this state of ... Sciences Reproducibility Problem. A recent roundtable discussion identifies challenges facing the scientific community ...
Reproducibility measures the dependence of the result on the inspector. If reproducibility variation is dependent, it means ... Reproducibility (inspector dependence). *Effects of gage variation on outgoing quality, estimates of the process performance ... Combination of the repeatability and reproducibility return the gages overall standard deviation, which is in turn reflected ... Measurement systems analysis (MSA) returns a gages repeatability and reproducibility in terms of standard deviations. Lower is ...
Results Bland-Altman plots showed negligible biases between test and retest sessions. ROI-based CVs revealed high ... Voxel-wise CV maps revealed high reproducibility for μA (CVs ~ 10%), but low reproducibility for OGSE metrics (CVs ~ 50%). ... The aims of this study were to characterize the test-retest reproducibility of in vivo OGSE and μA dMRI metrics in the mouse ... Bland-Altman plots and coefficients of variation (CV) were used to assess the reproducibility of OGSE and μA metrics. ...
To produce publication-quality results, these SPEC tools must be used. This helps ensure reproducibility of results by ... For results published on its web site, SPEC also requires that base results be published whenever peak results are published. ... 4. Results Disclosure. SPEC requires a full disclosure of results and configuration details sufficient to reproduce the results ... if the tester does not wish to have the result posted on the SPEC result pages, the result will not be posted. Nevertheless, as ...
Build Reproducibility is the ability to build software repeatedly, over time. The better reproducibility you can create, the ... That passion results in excellent discussions and lots of great ideas, especially… ...
Could an artificial intelligence-powered tool change the incentives to help fix the reproducibility crisis in biomedicine? ... the widespread irreproducibility of biomedical research results. Many factors contribute to irreproducible results and ... At the time, I well understood that reproducibility is truth. Without reproducibility, we cannot make significant progress in ... Ending the Reproducibility Crisis. By Shannon Brownlee, Bibiana Bielekova. Medical research that cant be replicated hinders ...
Methods and Results One thousand and thirty-three consecutive subjects undergoing health checkups were studied. CAVI was ... The purpose of this study was to evaluate the validity of CAVI compared with baPWV, the reproducibility of the measurement of ... The measurement of CAVI demonstrated good reproducibility and was not affected by the increase in BP during measurement. ...
D. Docampo, "Reproducibility of the Shanghai academic ranking of world universities results," Scientometrics, vol. 94, no. 2, ...
N2 - Replicability and reproducibility of experimental results are primary concerns in all the areas of science and IR is not ... AB - Replicability and reproducibility of experimental results are primary concerns in all the areas of science and IR is not ... abstract = Replicability and reproducibility of experimental results are primary concerns in all the areas of science and IR ... Breuer, T, Ferro, N, Fuhr, N, Maistro, M, Sakai, T, Schaer, P & Soboroff, I 2020, How to Measure the Reproducibility of System- ...
Results of search for su:{Reproducibility of results.} Refine your search. *. Availability. * Limit to currently available ... Results. Validation of analytical methods for food control : report of joint FAO/IAEA consultation, Vienna, Austria, 2-4 ... Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality : 10-year results ... Your search returned 5 results. Sort. Sort by:. Relevance. Popularity (most to least). Popularity (least to most). Author (A-Z) ...
Testing with prior batches as reference helps you obtain consistent results with the new batch relative to the previous batches ... we continue to strive for the highest quality measures to help meet the data reproducibility needs of your research. ... helping ensure that reagent builds provide consistent results to help give you assurance of experimental success and confidence ...
Moreover, the sensor exhibited good reproducibility and selectivity. Finally, the proposed sensor was efficiently used to ... This result indicates satisfactory reproducibility for the proposed electrode. ... The results obtained by the proposed method were certified with the MDA calibration curve. The results (Table 2) show that the ... According to this result, it can be said that the sensor is less sensitive at lower template concentrations, in agreement with ...
In the hunt for complex causes of the reproducibility crisis, universities and researchers may not be giving enough attention ... The Results of the Reproducibility Project Are In. Theyre Not Good. * New Center Hopes to Clean Up Sloppy Science and Bogus ... "There might be a limit to human lifespan, but we believe that their results provide no evidence," wrote a third, Adam Lenart ... A New Theory on How Researchers Can Solve the Reproducibility Crisis: Do the Math By Paul Basken ...
It speaks to the importance that SC gives to reproducibility and transparency in reproducing results." ... LLNL team wins SC21 Reproducibility Advancement Award. The 2021 International Conference for High Performance Computing, ... "SC has been a pioneer in the reproducibility effort, so getting an award in this field at SC is very exciting. ... The uncertainty and hesitancy of scientists to rely on the end results necessitates a better understanding of the performance ...
  • Measurement systems analysis (MSA) returns a gage's repeatability and reproducibility in terms of standard deviations. (complianceonline.com)
  • Combination of the repeatability and reproducibility return the gage's overall standard deviation, which is in turn reflected by its precision/tolerance (P/T) ratio. (complianceonline.com)
  • Three tests of a single vehicle model were conducted at three different test facilities, a total of nine tests, to evaluate repeatability and reproducibility. (sae.org)
  • Saunders, J. and Parent, D., "Repeatability and Reproducibility of Oblique Moving Deformable Barrier Test Procedure," SAE Technical Paper 2018-01-1055, 2018, https://doi.org/10.4271/2018-01-1055 . (sae.org)
  • 7 We have assessed the validity of volumetric measurements using a near focus transducer on a Doppler ultrasound phantom and determined the intraobserver and interobserver reproducibility of right common carotid artery (CCA) flow in newborn infants. (bmj.com)
  • Quantitation of p53 immunohistochemistry (IHC) by CAS was very reproducible by the same observer (r = .99), but its interobserver reproducibility was lower, and the measurement was time consuming (r = .81, 35 minutes). (nih.gov)
  • Both intraobserver and interobserver reproducibility by QPRODIT 5.2 were good. (nih.gov)
  • While intraobserver reproducibility of both Ki-67 LI and area% was good (r = .96, r = .99), interobserver reproducibility of Ki-67 LI was poorer than area% (r = .72 vs. r = .97). (nih.gov)
  • Few data are available regarding either the interobserver variability (reproducibility) of MR images in these circumstances or the correlation between images and the histopathologic appearances of the brain (accuracy). (ajnr.org)
  • For the assessment of interobserver reproducibility, it was applied twice within a 30-min interval by two different interviewers . (bvsalud.org)
  • The intraclass correlation coefficients for intraobserver and interobserver reproducibility were 0.95 and 0.90, respectively. (bvsalud.org)
  • Conclusions This is the first report addressing quality and reproducibility of WA in a large sample. (bmj.com)
  • To test the reproducibility and time effectiveness of two immunoquantitation and sampling methods in Barrett's esophagus (BE) mucosa. (nih.gov)
  • Ideally, research results are only worthy of attention, publication, and citation based if independent researchers can replicate them using a particular study's methods and materials. (the-scientist.com)
  • Methods and Results One thousand and thirty-three consecutive subjects undergoing health checkups were studied. (go.jp)
  • Moreover, we lack any reproducibility-oriented dataset, which would allow us to develop such methods. (ku.dk)
  • Thus, the acceptance of an article, particularly in journals that are very selective for high-impact findings, ends up depending not only on the research's methods but also on its results. (bvsalud.org)
  • The full description of methods is available in the Global Tuberculosis Report 2013 and the data sets are available from the WHO global TB database ( www.who.int/tb/country/en/ ). (who.int)
  • One of the signs of pseudoscience is a lack of reproducibility in their experiments. (rationalwiki.org)
  • Another point often related to the lack of reproducibility in biomedical research is the biased use of statistical models. (bvsalud.org)
  • Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). (snmjournals.org)
  • To assess the reproducibility of, and determine normative data for, flow volume measurements from the right common carotid artery (CCA) and its relation to left ventricular output (LVO) in stable term and preterm babies using Doppler ultrasound. (bmj.com)
  • Bland-Altman plots and coefficients of variation (CV) were used to assess the reproducibility of OGSE and μA metrics. (bepress.com)
  • The existence of such data did not alter the efforts of the Reproducibility Project to independently assess the reproducibility of the original studies. (elifesciences.org)
  • To assess inter-examiner reproducibility in the detection of 20 occlusal caries in permanent teeth using three diagnostic codes and criteria: WHO (1997), Nyvad and ICDAS-II. (bvsalud.org)
  • To assess the reproducibility and validity of the QUEFAC to children aged 7 to 10 years. (bvsalud.org)
  • After the development of instruments that assess food consumption, including the FFQ, it is necessary to evaluate their validity and reproducibility to determine sources of errors inherent to their use. (bvsalud.org)
  • The main cause attributed to the observations described above is a publication and incentive system that rewards the impact and novelty of scientific findings, but does not systematically assess their reproducibility, which is rarely considered in the evaluation of researchers (14,15). (bvsalud.org)
  • The CPSS has excellent reproducibility among prehospital personnel and physicians. (nih.gov)
  • RESULTS: Good to excellent reproducibility (intra-class correlation coefficients = 0.46-0.85) for MDT was found in controls at 22 degrees C. At 18 and 22 degrees C, pre-typing MDT differed between controls and cases by number of symptom sites marked on a hand-arm diagram (ANOVA, P or = 0.05), and by number of UEMSD case definitions met (ANOVA, P or = 0.05). (cdc.gov)
  • By comparison, better reproducibility was measured for some textural features describing local heterogeneity of tracer uptake, such as entropy and homogeneity, with a mean percentage difference of −2% ± 5.4% and 1.8% ± 11.5%, respectively. (snmjournals.org)
  • For the assessment of intraobserver reproducibility, it was applied again 15 days later by one of the interviewers . (bvsalud.org)
  • An ambitious project to test the reproducibility of biomedical experiments by Brazilian scientists is about to get under way. (nature.com)
  • Testing of the suggested model showed, that taking into account of initial state of bovine and carp spermatozoa and murine embryos increased reproducibility of results in average in 1.5 times, allowing the comparison of the results of various experiments. (org.ua)
  • Scientific experiments can also lack reproducibility, [2] but this just indicates either that the original experiment was flawed, that a better understanding of the problem is needed, or it is something that for its nature happens very often. (rationalwiki.org)
  • In contrast, academic journals are interested in novel experiments with significant results. (rationalwiki.org)
  • [4] A large-scale replication project was published in 2015 of the results of replication attempts of original published psychology experiments from 2008. (rationalwiki.org)
  • The results of the experiments are then published as a Replication Study, irrespective of the outcome, but subject to peer review to check that the designs and protocols contained in the Registered Report were followed. (elifesciences.org)
  • The experiments in the Reproducibility Project are typically powered to have an 80% probability of reproducing something that is true: this means that if we attempt to repeat three experiments from a paper, there is only a ~50% chance that all three experiments will yield significant p values, even if the original study was reproducible. (elifesciences.org)
  • Areas of concern that emerged during the peer review process included the limited budget for in vivo experiments and, in some cases, the possibility that the scope of the proposed experiments might not be sufficient to adequately explore the reproducibility of the original studies. (elifesciences.org)
  • As a first step, participants will carry out reproducibility experiments on a medical imaging application. (egi.eu)
  • However, some sources propose different uses of the two terms to distinguish the reproducibility of analyses based on the same data from those based on new experiments or observations (3). (bvsalud.org)
  • In the patient study, to evaluate the effect on BSI reproducibility, repeated bone scans were prospectively obtained from metastatic prostate cancer patients enrolled in 3 groups (Grp). (snmjournals.org)
  • The primary objective of this study was to evaluate the reproducibility of these heterogeneity measurements. (snmjournals.org)
  • The purpose of this study was to evaluate the validity of CAVI compared with baPWV, the reproducibility of the measurement of CAVI, and the effect of BP changes on CAVI and baPWV. (go.jp)
  • Training: How to evaluate and improve reproducibility? (egi.eu)
  • To cross-culturally adapt the Duke Activity Status Index (DASI) for use in Brazil and evaluate the reproducibility of the new (Brazilian Portuguese- language ) version. (bvsalud.org)
  • One factor holding back the development of new treatments is a complex and long-standing problem: the widespread irreproducibility of biomedical research results. (issues.org)
  • Indeed, of the approximately 1.5 million papers published in biomedical journals each year, researchers have estimated that at least half are so poorly designed, conducted, analyzed, or reported that the results cannot be replicated and therefore cannot be trusted. (issues.org)
  • As a writer and health policy expert with a long-standing interest in research integrity and the ethics of clinical studies, I (Shannon Brownlee) first became interested in reproducibility while writing a review of Richard Harris's 2017 book, Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions , in which he describes the reproducibility crisis in biomedical research. (issues.org)
  • abstract = 'Replicability and reproducibility of experimental results are primary concerns in all the areas of science and IR is not an exception. (ku.dk)
  • Nigéria, en décembre 2022 et publie depuis lors des rapports mensuels. (who.int)
  • Reproducibility was evaluated using technical errors, coefficients of variation (CV) for repeated measures, and intraclass correlation coefficients (ICC) for selected variables obtained on the main cohort, as well as on the ICQC and TCQC substudies. (lww.com)
  • If reproducibility variation is dependent, it means that inspector judgment (such as the definition of "finger tight" or how the inspector reads a dial gage) affects the outcome. (complianceonline.com)
  • Clinical psychology journals could improve transparency and reproducibility, as well as reduce bias, by requiring complete prospective trial registration for publication and by including trial registration numbers in all reports of RCTs. (rand.org)
  • New reporting standards for Nature journal authors are intended to improve transparency and reproducibility. (nature.com)
  • Ensuring systematic attention to reporting and transparency is only a small step toward solving the issues of reproducibility that have been highlighted across the life sciences. (nature.com)
  • However, its validity and reproducibility must be tested to assert that the instrument has a recognized quality. (bvsalud.org)
  • Only after evaluating the reproducibility and validity of the QUEFAC can the instrument is recognized as a quality tool to be used in the evaluation and monitoring of food consumption changes in longitudinal studies on lifestyle and health at school age. (bvsalud.org)
  • In this chapter, we will use "reproducibility" and "replicability" interchangeably, indicating that a similar result is obtained when collecting new data under conditions similar to those in the original study. (bvsalud.org)
  • A reproducibility crisis? (wikipedia.org)
  • The phenomenon is so widely recognized, it now has a name: the reproducibility crisis. (issues.org)
  • A recent headline-grabbing study about the limits of the human life span has drawn rebuttals with implications for how universities and scientists might approach the reproducibility crisis in research. (chronicle.com)
  • Universities, scientists, and advocacy groups may have overlooked the seriousness of that problem as they hunt for more complex or nefarious causes of the reproducibility crisis. (chronicle.com)
  • Lay people who learned about the low replication rate found in the Reproducibility Project subsequently reported a lower trust in psychology, compared to people who were told that a high number of the studies had replicated. (wikipedia.org)
  • The project is employing a Registered Report/Replication Study approach to publish its work and results. (elifesciences.org)
  • In 2015, the results of a large systematic replication of studies in cognitive and social psychology were released, which indicated success rates between 36% and 47% (9). (bvsalud.org)
  • In a paper published earlier in 2021 in the open peer review journal F1000 Research , we proposed a cost-effective, minimally intrusive solution for aligning the self-interest of researchers with the societal goal of maximizing research reproducibility and its value to human health. (issues.org)
  • Cross-cultural adaptation and assessment of reproducibility of the Duke Activity Status Index for COPD patients in Brazil. (bvsalud.org)
  • The results of their assessment have been published in the journal Cancer Epidemiology, Biomarkers & Prevention . (who.int)
  • Estimating the reproducibility of psychological science by B. A. Nosek et al. (rationalwiki.org)
  • Response to Comment on "Estimating the reproducibility of psychological science" , Anderson et al. (rationalwiki.org)
  • These concerns are even greater when data are pooled from several centers using the same procedures, as there might be differences in reproducibility across these centers. (lww.com)
  • For reproducibility, mean differences were observed for all nutrients investigated, correlation coefficients ranged from 0.12 to 0.54 and Kappa values from 0.01 to 0.39. (bvsalud.org)
  • Results Out of 814 IWA measurement attempts, 462 WFMs could be obtained. (bmj.com)
  • Measurement systems analysis (MSA), or gage reproducibility and repeatability (R&R) measures the precision. (complianceonline.com)
  • The measurement of CAVI demonstrated good reproducibility and was not affected by the increase in BP during measurement. (go.jp)
  • Our primary result is that the post-dive decrease in PC could be a predictor of decompression severity after diving. (who.int)
  • However, reproducing the "analytical phase" seems less difficult, as it would essentially require access to the primary and/or derived data and to the analytical tools used by the researchers to derive some result. (dlib.org)
  • We proposed a cost-effective, minimally intrusive solution for aligning the self-interest of researchers with the societal goal of maximizing research reproducibility and its value to human health. (issues.org)
  • Most scientific results that are shared today are just a summary of what researchers did and found. (crossref.org)
  • Researchers have shown that conerting waste plastics into graphene by rapid flash Joule heating also results in the production of hydrogen. (materialstoday.com)
  • This tutorial is aimed at all researchers interested in evaluating and improving the reproducibility of their research results. (egi.eu)
  • Calibrators were required to be within 15% of their nominal values for all assays in which results above the lower limit of detection were reported. (cdc.gov)
  • The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada. (lww.com)
  • Results were consistent for the main cohort, the ICQC sample, the TCQC sample, and across all four Clinical Centers. (lww.com)
  • Day-to-day variations are small and reproducibility is high for maximal values of heart rate, ventilation, V̇O 2 and V̇CO 2 at each of the four Clinical Centers of the HERITAGE Family Study. (lww.com)
  • Reproducibility is the ability to produce the same findings, using the same methodologies as the original work, but on a different dataset (for instance, collected from a different set of participants). (wikipedia.org)
  • Moreover, we also develop a reproducibility-oriented dataset, which allows us to validate our measures and which can also be used to develop future measures. (ku.dk)
  • Analytical reproducibility in scientific research has become a keenly discussed topic within scientific research organizations and acknowledged as an important and fundamental goal to strive for. (dlib.org)
  • Reproducibility of scientific research is an essential principle within science. (dlib.org)
  • Scientific results should stand the scrutiny of the research community and should be verifiable by peers. (dlib.org)
  • Failure to reproduce scientific results can have many causes. (dlib.org)
  • An important step in the generation of scientific results lies in the computational analysis of the primary data or derived secondary data. (dlib.org)
  • A recent roundtable discussion identifies challenges facing the scientific community regarding a lack of reproducible results in the literature. (the-scientist.com)
  • But for much of the scientific literature, results aren't reproducible at all. (the-scientist.com)
  • Cory Fournier, an adjunct instructor in mathematics at the University of Massachusetts at Lowell, came to that conclusion earlier this year, after he cobbled together $1,000 in scarce union funds to journey to a big national conference on scientific reproducibility. (chronicle.com)
  • Reproducibility is a key part of the scientific method and refers to the possibility of reproducing an experimental result by a third party following the same procedures as the original experimenter. (rationalwiki.org)
  • Our system leverages NSLS-II Bluesky for experimental data acquisition, captures analysis parameters, and enriches the search space with results from the scientific literature (Figure 1). (bnl.gov)
  • Within the ReproVIP project, we aim at evaluating and improving the reproducibility of scientific results obtained with VIP. (egi.eu)
  • The process of verification and correction of published science, however, occurs in a non systematic way, which means that reproducibility is not guaranteed by scientific publication in its current format. (bvsalud.org)
  • It should be noted that the reproducibility of a scientific finding can be defined in many ways, and that there is no consensus on the use of the terms "reproducible" and "replicable" (1,2). (bvsalud.org)
  • This leads to a literature that is full of positive and impacting results, but usually at the expense of selective or biased analyses and inflated effects, which distort our perception of the scientific problems under study (16). (bvsalud.org)
  • Thus, it appears feasible to strive for a more reduced version of reproducibility that we will refer to as "analytical reproducibility" in order to ensure that a third party researcher could reproduce the computational/statistical analysis performed on derived data to yield a particular conclusion, thereby being able to independently verify the results and research hypothesis. (dlib.org)
  • During the theoretical part, the audience will learn about several issues in computational reproducibility (across computing environments, libraries, versions) and how they can be handled through technical solutions. (egi.eu)
  • Furthermore, in-silico evaluation of primers, especially those for amplification of archaeal 16S rRNA gene regions, does not necessarily reflect the results obtained in experimental approaches. (frontiersin.org)
  • The checklist focuses on experimental and analytical design elements that are critical for the interpretation of research results but that are often reported incompletely. (nature.com)
  • The Reproducibility Project: Psychology was a crowdsourced collaboration of 270 contributing authors to repeat 100 published experimental and correlational psychological studies. (wikipedia.org)
  • The project pulled these studies from three different journals, Psychological Science, the Journal of Personality and Social Psychology, and the Journal of Experimental Psychology: Learning, Memory, and Cognition, published in 2008 to see if they could get the same results as the initial findings. (wikipedia.org)
  • Our manufacturing process adheres to standard operating procedures (SOPs) and guidelines, conforming to ISO requirements, and is strictly followed, helping ensure that reagent builds provide consistent results to help give you assurance of experimental success and confidence in your research. (bdbiosciences.com)
  • In experimental psychology, several warning signs about the low reproducibility of published findings emerged in the early 2010s (7,8). (bvsalud.org)
  • Reproducibility of maximal exercise test data in the HERITAG. (lww.com)
  • However, the mere availability of data is not enough to ensure analytical reproducibility. (dlib.org)
  • thus, we continue to strive for the highest quality measures to help meet the data reproducibility needs of your research. (bdbiosciences.com)
  • The advent of automated sensing technologies in crop science, in addition to the use of drones and cameras, has resulted in a flood of new data. (jmp.com)
  • The underlying data are not available, making it difficult to verify and replicate results. (crossref.org)
  • Addressing this error resulted in the removal of some records from various stored biospecimen data files between 1999 and 2018 that did not meet program standards. (cdc.gov)
  • In recent years, data on the reproducibility of published findings in some areas of research has become available. (bvsalud.org)
  • These tests, however, are usually applied flexibly after data collection and examination, and end up being reported selectively according to the results found (18,19). (bvsalud.org)
  • Several regional heterogeneity parameters such as variability in the intensity and size of regions of homogeneous activity distribution had reproducibility similar to that of SUV measurements, with 95% confidence intervals of −22.5% to 3.1% and −1.1% to 23.5%, respectively. (snmjournals.org)
  • Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach. (elifesciences.org)
  • The aim of the Reproducibility Project: Cancer Biology, which is a collaboration between the Center for Open Science and Science Exchange, is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally. (elifesciences.org)
  • Results Bland-Altman plots showed negligible biases between test and retest sessions. (bepress.com)
  • It will help attendees understand difference between calibration and precision, components of gage capability, procedure for a gage reproducibility and repeatability study and much more. (complianceonline.com)
  • The objective of this study was to validate and verify the reproducibility of the CPSS when used by prehospital providers. (nih.gov)
  • Together, these quality controls products can be utilized to verify test performance, track variations in results, follow lot-to-lot test kit reproducibility, monitor individual operator performance and determine aberrant long-term trends in laboratory results. (prweb.com)
  • Results: Of the 120 papers identified, only 14 were related to systematic reviews. (researchgate.net)
  • Two trained observers assessed reproducibility by examining multiple brain regions independently with current criteria and then defining and applying improved criteria. (ajnr.org)
  • In this study, we observed that the automated BSI accuracy and reproducibility were dependent on scanning speed but not on the vendor-specific γ-cameras. (snmjournals.org)
  • Rampes, et al 2 used the term reproducibility , which is part of the domain of reliability. (jrheum.org)
  • 9 , 10 , 11 Based on the results of the Quality Appraisal of Diagnostic Reliability (QAREL) checklist and Tables 1-3 in the study of Rampes, et al , 2 it could be assumed that the patient populations of the 14 included studies were representative of the population of interest, were stable, and contained some degree of heterogeneity. (jrheum.org)
  • The primary purpose of this consortium was to examine the reliability and reproducibility of fMRI results. (virginia.edu)
  • The responses of the vehicle and its occupants were evaluated using three different methodologies to quantify the repeatability within a single test facility and reproducibility among the three test facilities. (sae.org)
  • Overall, this test series demonstrated repeatable and reproducible results for the OMDB, vehicle, and driver occupant in the oblique offset test procedure. (sae.org)
  • Utilizing ZeptoMetrixâ„¢ NATtrolâ„¢ External Run Controls on a consistent basis helps to monitor testing performance to maximize additional confidence in a patient's reported results. (prweb.com)
  • The patient's results come back. (medscape.com)
  • In practice, however, reproducing or confirming previous research results can be a major challenge. (dlib.org)
  • In fact, meta-studies in psychology, medicine and also computer science have documented the challenges involved therein and they have empirically shown that the success rate in reproduction of research results is low. (dlib.org)
  • Conditions of reproducibility increase for cryobiological research results were examined with the proposed mathematical model. (org.ua)
  • It has been shown that increase of reproducibility of research results is provided with taking into account the initial state of biological material and the efficiency of its using. (org.ua)
  • Application of this mathematical model increases the reproducibility of research results up to 5 times that provides the obtaining significant result when reducing the biological material number to 25 times. (org.ua)
  • The authors emphasized that the findings reflect a problem that affects all of science and not just psychology, and that there is room to improve reproducibility in psychology. (wikipedia.org)
  • Psychology results evaporate upon further review: Surprising reports, findings with marginal statistical significance least likely to be reproduced, study concludes by Bruce Bower (2:00pm, August 27, 2015) Science News . (rationalwiki.org)
  • Criteria that provide substantial reproducibility and accuracy for the interpretation of MR imaging findings very early after birth asphyxia can be derived. (ajnr.org)
  • The aim of this study therefore was to examine the reproducibility of MR images obtained from a group of neonates soon after birth asphyxia and to compare MR imaging appearances with neuropathologic findings. (ajnr.org)
  • The panel findings, along with gestational age, can suggest a number of fetal abnormalities, depending on the results pattern. (medscape.com)
  • Scientists from the International Agency for Research on Cancer (IARC) and partner institutions assessed the intra-laboratory and inter-observer reproducibility of a rapid test for detection of high-risk human papillomavirus (HPV) types at three different levels of the health-care system in one urban region and one rural region in the United Republic of Tanzania. (who.int)
  • The aims of this study were to characterize the test-retest reproducibility of in vivo OGSE and μA dMRI metrics in the mouse brain at 9.4 Tesla and provide estimates of required sample sizes for future investigations. (bepress.com)
  • Test-retest reproducibility of in vivo oscillating gradient and microscopic anisotropy diffusion MRI in mice at 9.4 Tesla" PLoS ONE Vol. 16 Iss. (bepress.com)
  • Log into MyQuest ® to book or reschedule a lab visit, view test results, and more. (questdiagnostics.com)
  • We're excited to have you here for our debate: Should patients have immediate access to cancer test results via electronic health records (EHRs)? (medscape.com)
  • You know our patients are getting their test results and are misunderstanding them. (medscape.com)
  • The project has illustrated the growing problem of failed reproducibility in social science. (wikipedia.org)
  • This project has started a movement that has spread through the science world with the expanded testing of the reproducibility of published works. (wikipedia.org)
  • There have been multiple implications of the Reproducibility Project. (wikipedia.org)
  • The results of the Reproducibility Project might also affect public trust in psychology. (wikipedia.org)
  • At Bielefeld University, nine research project groups from varied disciplines have embarked on a "reproducibility" journey by collaborating on the Conquaire project as case study partners. (dlib.org)
  • As a result of this project, DeCS 2018 version was augmented by 3 descriptors related to Gender, 4 to Equity, 19 to Human Rights and 39 to Ethnicity, in addition to few in Universal Health Coverage and Universal Access, and in e-Health, two other themes of the Pan American Health Organization. (bvsalud.org)
  • The causes and remedies for this state of affairs was the topic of a recent panel discussion titled "Sense and Reproducibility," held at the annual meeting of the American Society for Cell Biology in San Francisco, California. (the-scientist.com)
  • In the reproducibility study, MR imaging agreement was moderate when current criteria were used ( k = .44). (ajnr.org)
  • The QUEFAC was not valid for evaluation of usual food consumption of the last three months in children aged 7 to 10 years in São Paulo and presented moderate reproducibility for energy, protein, calcium, phosphorus, iron, potassium, magnesium and vitamin B2. (bvsalud.org)
  • I was not surprised that few produced replicable results. (issues.org)
  • Build Reproducibility is the ability to build software repeatedly, over time. (activestate.com)
  • It is the extent to which a tool can produce the same result when used repeatedly under the same circumstances. (news-medical.net)
  • This study examines the reproducibility and accuracy of MR imaging soon after severe birth asphyxia. (ajnr.org)
  • The reproducibility of maximum and mean SUV was similar to that in previously reported studies, with a mean percentage difference of 4.7% ± 19.5% and 5.5% ± 21.2%, respectively. (snmjournals.org)
  • Until now, only a few studies have investigated the physiologic reproducibility of such measurements, almost exclusively focusing on SUVs ( 9 - 11 ) and more recently on MATV computed using different segmentation algorithms ( 12 , 13 ). (snmjournals.org)
  • Reproducibility studies were performed on 30 newborn infants by two observers. (bmj.com)
  • In their initial publications 97 of these 100 studies claimed to have significant results. (wikipedia.org)
  • Since the publication of the original studies, published and unpublished results from other labs have suggested that a number of the studies are reproducible, but there is concern that some of them may not be reproducible. (elifesciences.org)
  • Therapeutic studies - investigation of treatment results. (researchgate.net)
  • Since then, similar projects have found reproducibility rates between 30% and 85% in different samples of studies from the social and behavioral sciences (10-13). (bvsalud.org)
  • This creates a problematic conflict of interest for the authors, as career advancement depends on obtaining particular results, biasing the conduct and the analysis of studies (17). (bvsalud.org)
  • Glenn Begley, former head of research at Amgen and roundtable panel member, spoke of his March revelation that the biotech company's scientists were unable to replicate the results of 47 out of 53 papers that were seminal to launching drug-discovery programs. (the-scientist.com)
  • Whether one is considering the percentage difference in PET-derived parameters between successive scans or the absolute values on a baseline scan, the definition of thresholds to identify response or progressive disease requires, among others, an evaluation of their physiologic reproducibility. (snmjournals.org)
  • The reproducibility revealed precise answers in the occlusal caries lesions diagnosis according to the criteria used. (bvsalud.org)
  • dental diagnosis, tooth decay, reproducibility. (bvsalud.org)
  • We will all be using a checklist ( http://www.nature.com/authors/policies/checklist.pdf ) intended to prompt authors to disclose technical and statistical information in their submissions and to encourage referees to consider aspects important for research reproducibility. (nature.com)
  • As underscored in three Correspondences in this issue, statistical analysis of reproducibility itself is still immature. (nature.com)