REM Sleep Behavior Disorder: A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Sleep-Wake Transition Disorders: Parasomnias characterized by behavioral abnormalities that occur during the transition between wakefulness and sleep (or between sleep and wakefulness).Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.Dreams: A series of thoughts, images, or emotions occurring during sleep which are dissociated from the usual stream of consciousness of the waking state.Polysomnography: Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)REM Sleep Parasomnias: Abnormal behavioral or physiologic events that are associated with REM sleep, including REM SLEEP BEHAVIOR DISORDER.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Video Recording: The storing or preserving of video signals for television to be played back later via a transmitter or receiver. Recordings may be made on magnetic tape or discs (VIDEODISC RECORDING).Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Parasomnias: Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Parasomnias are generally divided into four groups: arousal disorders, sleep-wake transition disorders, parasomnias of REM sleep, and nonspecific parasomnias. (From Thorpy, Sleep Disorders Medicine, 1994, p191)Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.Cataplexy: A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)Attention Deficit and Disruptive Behavior Disorders: Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.Olfaction Disorders: Loss of or impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATORY TRACT INFECTIONS; CRANIOCEREBRAL TRAUMA; SMOKING; and other conditions.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Sleep Stages: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Guadeloupe: The name of two islands of the West Indies, separated by a narrow channel. Their capital is Basse-Terre. They were discovered by Columbus in 1493, occupied by the French in 1635, held by the British at various times between 1759 and 1813, transferred to Sweden in 1813, and restored to France in 1816. Its status was changed from colony to a French overseas department in 1946. Columbus named it in honor of the monastery of Santa Maria de Guadalupe in Spain. (From Webster's New Geographical Dictionary, 1988, p470 & Room, Brewer's Dictionary of Names, 1992, p221)Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Sleep Disorders, Intrinsic: Dyssomnias (i.e., insomnias or hypersomnias) associated with dysfunction of internal sleep mechanisms or secondary to a sleep-related medical disorder (e.g., sleep apnea, post-traumatic sleep disorders, etc.). (From Thorpy, Sleep Disorders Medicine, 1994, p187)Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.Neurologic Examination: Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.Eye Movement Measurements: Methods and procedures for recording EYE MOVEMENTS.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.

*  Most recent papers with the keyword Parasomnias | Read by QxMD
REM) parasomnias. REM sleep parasomnias include nightmares, REM behavior disorder, and sleep paralysis, whereas NREM sleep ... REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often ... REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle ... REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to ...
  https://www.readbyqxmd.com/keyword/17311
*  REM sleep behavior disorder | Behavenet
This Parasomnia is characterized by such vigorous, even violent, integrated motor activity during sleep that many suffer injury ... REM sleep behavior disorder. (rapid eye movement sleep behavior disorder) is a kind of: * mental disorder ... mental disorder » Parasomnias * mental disorder » Sleep Disorders » Parasomnias * mental disorder » Sleep Disorders ...
  https://www.behavenet.com/index.php/rem-sleep-behavior-disorder
*  Riverside Healthcare - REM Sleep Behavior Disorder
REM Sleep Behavior Disorder REM Sleep Behavior Disorder (RBD) is the most common REM sleep parasomnia treated at Riverside's ... The treatment for RBD is very specific to each patient experiencing this disorder. Contact the Sleep Disorder Institute of ... RBD is treatable at the Sleep Disorder Institute of Riverside Medical Center. Various medications are prescribed for RBD based ... Sleep Disorder Institute. Individuals with this disorder tend to act out their dreams which can result in repeated injury such ...
  https://www.riversidehealthcare.org/rem-sleep-behavior-disorder.html
*  REM Sleep Behavior Disorder - Diagnosis and Treatment
RBD is a disorder that can get worse over time. This can put you or your bed partner in danger. RBD also tends to be linked to ... REM Sleep Behavior Disorder - Diagnosis & Treatment. Diagnosis. RBD is a disorder that can get worse over time. This can put ... Examples of these disorders include sleep apnea and periodic limb movement disorder. The best sleep study will also record your ... People with RBD are at risk for other sleep disorders. As a result, your doctor will likely have you take an overnight sleep ...
  http://www.sleepeducation.org/sleep-disorders-by-category/parasomnias/rem-sleep-behavior-disorder/diagnosis-treatment
*  REM Sleep Behavior Disorder Screening Questionnaire - Wikipedia
"REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study using the REM sleep behavior ... "The REM sleep behavior disorder screening questionnaire: Validation study of a Japanese version". Sleep Medicine. 10 (10): 1151 ... "The REM Sleep Behavior Disorder Screening Questionnaire-A New Diagnostic Instrument". Movement Disorders. 22 (16): 2386-2393. ... "Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson's disease patients". Sleep Medicine. 12 ...
  https://en.wikipedia.org/wiki/REM_Sleep_Behavior_Disorder_Screening_Questionnaire
*  REM sleep behavior disorder was associated with Parkinson's disease: a community-based study | Springer for Research &...
REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD ( pRBD) in a rural community based ... probable REM sleep behavior disorder; PSG, polysomnographic; RBD, REM sleep behavior disorder; RBD1Q-C, Chinese REM sleep ... REM sleep behavior disorder screening questionnaire -Hong Kong; RBDSQ, REM sleep behavior disorder screening questionnaire ... Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep ...
  https://rd.springer.com/article/10.1186/s12883-016-0640-1
*  Most recent papers with the keyword REM sleep behavior disorders | Read by QxMD
Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. ... ventromedial-medulla-inhibitory-neuron-inactivation-induces-rem-sleep-without-atonia-and-rem-sleep-behavior-disorder ... Insomnia, hypersomnia and REM Sleep Behavior Disorder (RSBD) during sleep are major problems for patients suffering from ... of-lewy-body-disease-in-patients-with-late-onset-psychiatric-disorders-using-clinical-history-of-rem-sleep-behavior-disorder- ...
  https://www.readbyqxmd.com/keyword/48333
*  Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder [Lett.] :: MPG...
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder [Lett.] ... sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder [Lett.]. Journal of Sleep ... Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder [Lett.] ...
  http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1645995
*  The Dangers of REM Behavior Disorder - Sleep Center - Everyday Health
REM behavior disorder is a dangerous sleep disorder in which people physically act out their dreams during REM sleep. Learn who ... REM Behavior Disorder: No Sweet Dreams. REM sleep disorder is the acting out of dreams during the REM phase of sleep. During ... REM behavior disorder is a sleep disorder characterized by intense physical activity during REM sleep.. People who experience ... Everyday Health Sleep Disorders Sleep The Dangers of REM Behavior Disorder. Kicking, punching, hitting, grabbing, and leaping ...
  https://www.everydayhealth.com/sleep/other-disorders/rem-behavior-disorder.aspx
*  HealthlinkUSA - Discussion Forum for Treatments, Symptoms and Causes of 700 health conditions & diseases.
REM Sleep Behavior Disorder Sally Message 1 of 1 Renee: I have REM SBD and its no fun at all. I do all the things your friends ... The drugs I mentioned are for Parkinson's Disease to calm your muscles so you won't be able to move as much in your sleep. ... Have been to a sleep clinic and no help. A neurologist has me on Clonazapam and Sinemet. Helps a little but still recurring. In ...
  http://www.healthlinkusa.com/hlu_90702_1_rem-sleep-behavior-disorder-aspx
*  REM Behavior Disorder - World Sleep Foundation
REM sleep parasomnias include nightmares, characterized by frightening dreams and autonomic arousal, and REM behavior disorder ... The most common primary parasomnias are disorders of arousal and REM sleep disorders. Disorders of arousal include confusional ... NREM sleep, or REM sleep and are often divided into two groups. Primary parasomnias are disorders of sleep states per se, and ... The basic sleep architecture and sleep macrostructure is normal in patients with disorders of arousal. 'Hypersynchronous delta ...
  http://worldsleepfoundation.org/rem-behavior-disorder
*  Dr. David Karas, MD - Madison, CT - Ear, Nose, and Throat & Pediatric Otolaryngology (Ear, Nose & Throat) | Healthgrades.com
Sleep Disorders. Sleep Disorders. includes other areas of care:. - REM Sleep Behavior Disorder. ... Sleep Apnea. Sleep Apnea. includes other areas of care:. - Central Sleep Apnea. ...
  https://www.healthgrades.com/physician/dr-david-karas-2p4mn
*  Search of: Tremor - List Results - ClinicalTrials.gov
Movement Disorders (Incl Parkinsonism). *Tremor Familial Essential, 1. *REM Sleep Behavior Disorder ... Effect of Deep Brain Stimulation (DBS) on Sleep Architecture in Patients With Movement Disorders. *Parkinson's Disease ... Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal ... MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.. * ...
  https://clinicaltrials.gov/ct2/results?term=Tremor&pg=2
*  Search of: 'Ocular motility disorders' - List Results - ClinicalTrials.gov
Movement Disorders (Incl Parkinsonism). *Tremor Familial Essential, 1. *REM Sleep Behavior Disorder ... MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.. * ... Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies. *Congenital ... The change in the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Scale (SWAN) ...
  https://clinicaltrials.gov/ct2/results?cond=%22Ocular+motility+disorders%22&show_rss=Y&sel_rss=new14
*  Dr. Marlene Bednar, MD - Greenville, PA - Adult Neurology & Clinical Neurophysiology | Healthgrades.com
REM Sleep Behavior Disorder. *Radiculitis. *Radiculopathy (Not Due to Disc Displacement). *Rapid-Onset Dystonia Parkinsonism ( ...
  https://www.healthgrades.com/physician/dr-marlene-bednar-2smxc
*  Search of: SNCA - List Results - ClinicalTrials.gov
REM Sleep Behavior Disorder. *(and 2 more...). Observational. *New York University School of Medicine ... 2) Characterize the sleep, olfactory,medical and neurologic assessments of early symptomatic PD subjects compared to age- and ... Biological: Variation of hyper dopaminergic behaviors of Parkinson's disease. Interventional. Phase 3. *Centre Hospitalier ... Study of the Efficacy of N-acetylcysteine (NAC) on Impulse Control Disorders (TCI) Induced by Dopaminergic Treatments in ...
  https://clinicaltrials.gov/ct2/results?term=SNCA&show_flds=Y
*  Search of: narcolepsy | Recruiting, Not yet recruiting, Available Studies - List Results - ClinicalTrials.gov
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder. * ... Fewer PSG transitions from N1, N2, N3, and REM sleep to wake sleep and from N2, N3, and REM sleep to N1 ... Screening Questionnaire for Respiratory Muscle Weakness and Sleep-disordered Breathing in Neuromuscular Disorders. * ... Sleep will be measured using subjective reports (Karolinska Sleep Diary on Daily Sleep Assessment). ...
  https://clinicaltrials.gov/ct2/results?term=narcolepsy&recr=Open&rslt=&type=&cond=&intr=&titles=&outc=&spons=&lead=&id=&state1=&cntry1=&state2=&cntry2=&state3=&cntry3=&locn=&gndr=&rcv_s=&rcv_e=&lup_s=&lup_e=
*  DaTSCAN Imaging in Aging and Neurodegenerative Disease - Full Text View - ClinicalTrials.gov
Experimental: REM sleep behavior disorder REM sleep behavior disorder. Drug: I-123 Ioflupane solution injection prior to SPECT ... Mental Disorders. Parkinsonian Disorders. REM Sleep Behavior Disorder. Brain Diseases. Central Nervous System Diseases. Nervous ... Cognition Disorders. Basal Ganglia Diseases. Movement Disorders. REM Sleep Parasomnias. Parasomnias. Sleep Wake Disorders. ... and in subjects with REM sleep behavior disorder. The findings on DaTscan in subjects with these various disorders will be ...
  https://clinicaltrials.gov/ct2/show/NCT01453127?term=Corticobasal+Degeneration&rank=5
*  Search of: Recruiting, Not yet recruiting, Available Studies | 'Narcolepsy' - List Results - ClinicalTrials.gov
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder. * ... Fewer PSG transitions from N1, N2, N3, and REM sleep to wake sleep and from N2, N3, and REM sleep to N1 ... Sleep Disorders Center of Alabama. Birmingham, Alabama, United States. *Sleep Medicine Specialists of California. San Ramon, ... The Role of the Circadian System in Neurological Sleep-wake Disorders. *Narcolepsy 1 ...
  https://clinicaltrials.gov/search/open/condition=%22Narcolepsy%22
*  Search of: Recruiting, Not yet recruiting, Available Studies | 'Neurodegenerative Diseases' - List Results - ClinicalTrials.gov
REM Sleep Behavior Disorder. *Neurodegenerative Diseases. Observational. *Chinese University of Hong Kong ... Difference of change of the score of the MDS-UPDRS part III (Movement Disorder Society-Sponsored Revision of the Unified ... In subjects with neuromuscular disorders, we would be mainly doing explorational studies to better understand the use of EIM in ... The Program for the Study of Neurodevelopment in Rare Disorders, Children's Hospital of Pittsburgh of UPMC. Pittsburgh, ...
  https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Neurodegenerative+Diseases%22
*  Natural History Study of Synucleinopathies - Full Text View - ClinicalTrials.gov
REM sleep behavior disorder, RBD Patients that have rapid eye movement sleep behavior disorder. ... Mental Disorders. Pure Autonomic Failure. Lewy Body Disease. REM Sleep Behavior Disorder. Parkinsonian Disorders. Basal Ganglia ... Another indication of this spread is that acting out dreams (i.e., REM sleep behavior disorder, RBD) a problem that occurs when ... Patients With Synucleinopathies Neurogenic Orthostatic Hypotension Pure Autonomic Failure REM Sleep Behavior Disorder Parkinson ...
  https://clinicaltrials.gov/ct2/show/NCT01799915?term=Multiple+System+Atrophy+with+Orthostatic+Hypotension&rank=8
*  Investigation of Clinical Feature and Brain Function in Narcoleptic Patients - Full Text View - ClinicalTrials.gov
REM Sleep Behavior Disorder. Disorders of Excessive Somnolence. Sleep Disorders, Intrinsic. Dyssomnias. Sleep Wake Disorders. ... Narcolepsy with REM sleep disorder lable(20) and Narcolepsy without REM sleep disorderlable (20) ... Narcolepsy with REM sleep disorder lable(20) and Control subjects lable(20) ... occurrence of sleep onset rapid eye movement period(SOREMP), sleep stages distribution, and sleep arousle and leg movement and ...
  https://clinicaltrials.gov/ct2/show/NCT03376568?cond=%22narcolepsy%22&rank=40

Exploding head syndrome: Exploding head syndrome (EHS) is a condition in which a person hears loud noises (such as a bomb exploding, a gunshot, or a cymbal crash) or experiences an explosive feeling when falling asleep or waking up. These noises have a sudden onset, are typically brief in duration, and are often jarring for the sufferer.ClonazepamNightmare: A nightmare is an unpleasant dream that can cause a strong emotional response from the mind, typically fear but also despair, anxiety and great sadness. The dream may contain situations of discomfort, psychological or physical terror.PolysomnographyNarcolepsyGregor Wenning: Gregor K. Wenning (* born 21st March1964 in Horstmar, Westfalia) is a German Neurologist best known for his clinical and scientific work in Parkinson's disease and atypical Parkinsonian disorders, particularly multiple system atrophy (MSA).Dennis Walsh: Dennis Walsh (12 June 1933 – 1 June 2005) was an English astronomer, born into a poor family in Manchester. He was best known for his discovery in 1979 of the first example of a gravitational lens which he made while studying quasars found in the Jodrell Bank 966MHz survey.Jerry L. McLaughlin: Jerry L. McLaughlin is a researcher who has conducted research for 28 years studying plants looking for molecules that fight cancer at Purdue University's School of Pharmacy.Causes of Parkinson's disease: Parkinson's disease (PD) is a degenerative disorder of the central nervous system. Most people with PD have idiopathic Parkinson's disease (having no specific known cause).Non-rapid eye movement sleepProfessional DiscAging movement control: Normal aging movement control in humans is about the changes on the muscles, motor neurons, nerves, sensory functions, gait, fatigue, visual and manual responses, in men and women as they get older but who do not have neurological, muscular (atrophy, dystrophy...) or neuromuscular disorder.Benign neonatal sleep myoclonus: Benign neonatal sleep myoclonus (BNSM) is the occurrence of myoclonus (jerky movements) during sleep. It is not associated with seizures.Centre for Research in Neurodegenerative DiseasesCataplexyOlfactory sulcus: The medial orbital gyrus presents a well-marked antero-posterior sulcus, the olfactory sulcus, for the olfactory tract.Invasion of Guadeloupe (1794): The Invasion of Guadeloupe was a British attempt in 1794 to take and hold the island of Guadeloupe in the West Indies during the French Revolutionary Wars. The British had negotiated with the French planters, Ignace-Joseph-Philippe de Perpignan and Louis de Curt, who wished to gain British protection, as the French Constitutional Assembly was passing a law abolishing slavery.Quantitative electroencephalography: Quantitative electroencephalography (QEEG) is a field concerned with the numerical analysis of electroencephalography data and associated behavioral correlates.Central tegmental tract: The central tegmental tractKamali A, Kramer LA, Butler IJ, Hasan KM. Diffusion tensor tractography of the somatosensory system in the human brainstem: initial findings using high isotropic spatial resolution at 3.

(1/116) Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases.

We describe demographic, clinical, laboratory and aetiological findings in 93 consecutive patients with rapid eye movement (REM) sleep behaviour disorder (RBD), which consists of excessive motor activity during dreaming in association with loss of skeletal muscle atonia of REM sleep. The patients were seen at the Mayo Sleep Disorders Center between January 1, 1991 and July 31, 1995. Eighty-one patients (87%) were male. The mean age of RBD onset was 60.9 years (range 36-84 years) and the mean age at presentation was 64.4 years (37-85 years). Thirty-two per cent of patients had injured themselves and 64% had assaulted their spouses. Subdural haematomas occurred in two patients. Dream content was altered and involved defence of the sleeper against attack in 87%. The frequency of nocturnal events decreased with time in seven untreated patients with neurodegenerative disease. MRI or CT head scans were performed in 56% of patients. Although four scans showed brainstem pathology, all of these patients had apparently unrelated neurodegenerative diseases known to be associated with RBD. Neurological disorders were present in 57% of patients; Parkinson's disease, dementia without parkinsonism and multiple system atrophy accounted for all but 14% of these. RBD developed before parkinsonism in 52% of the patients with Parkinson's disease. Five of the 14 patients with multiple system atrophy were female, and thus the strong male predominance in RBD is less evident in this condition. Psychiatric disorders, drug use or drug withdrawal were rarely causally related to RBD. Clonazepam treatment of RBD was completely or partially successful in 87% of the patients who used the drug. We conclude that RBD is a well-defined condition and that descriptions from different centres are fairly consistent. It is commonest in elderly males and may result in serious morbidity to patients and bed partners. There is a strong relationship to neurodegenerative disease, especially Parkinson's disease, multiple system atrophy and dementia, and neurologists should explore the possibility of RBD in patients with these conditions. RBD symptoms may be the first manifestations of these disorders and careful follow-up is needed. Neuroimaging is unlikely to reveal underlying disorders not suspected clinically. We confirm the effectiveness of clonazepam, but note that attention to the safety of the bed environment may be sufficient for patients with contraindications to the drug.  (+info)

(2/116) Rapid eye movement sleep behaviour disorder, depression and cognitive impairment. Case study.

BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder is a relatively new diagnostic category. It has never before been associated with a treatable depressive condition. AIMS: To report on a 74-year-old man with a history of depression and REM sleep behaviour disorder, associated with mild cognitive impairment. METHOD: Assessment using brain CT, MRI, PET, electroencephalography, neuropsychological testing and nocturnal polysomnography. RESULTS: Depression was treated with sertraline. Sleep laboratory studies supported a diagnosis of REM sleep behaviour disorder, which was treated with clonazepam. Sleep apnoea, revealed later, was treated with nasal continuous positive airways pressure. Brain MRI showed mild atrophy, but neuropsychological testing indicated no progressive cognitive deterioration. CONCLUSIONS: This case draws attention to REM sleep behaviour disorder and its potential interaction with depression and cognitive impairment, producing symptoms which can be mistaken for early dementia. The diagnosis of REM sleep behaviour disorder is easily missed, and it requires careful history-taking and sleep investigation in all suspected sufferers. Associated neurological, sleep and psychiatric conditions (including depression and cognitive impairment) may confound the diagnosis.  (+info)

(3/116) Interobserver reliability of ICSD-R criteria for REM sleep behaviour disorder.

We estimated the interobserver reliability (IR) of the diagnosis of rapid eye movement (REM) Sleep Behaviour Disorder (RBD) among trained neurologists, with the application of International Classification of Sleep Disorders Revised (ICSD-R), by means of videotaped interviews of people with motor sleep behaviour disorders of different nature. IR of clinical judgement for the diagnosis of RBD was "substantial" (Kappa 0.65); nevertheless, some criteria ('limb or body movement associated with dream mentation', criterion B, and 'sleep behaviours (that) disrupt sleep continuity', criterion C3) showed a 'moderate' IR, resulting from the intrinsic limitations of the patient report and terminological ambiguity. Further clarification of terminology of the ICSD-R criteria would be useful to improve the reliability.  (+info)

(4/116) Falling asleep.

We describe a 74-year-old woman who presented with a history of falling from bed in association with vivid dreams and physical violence towards her spouse. A clinical diagnosis of rapid eye movement sleep behaviour disorder was made and complete resolution of her symptoms was achieved with first line treatment.  (+info)

(5/116) Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

REM sleep behaviour disorder (RBD) and olfactory dysfunction are common and very early features of alpha-synucleinopathies, in particular Parkinson's disease. To investigate the hypothesis that these two clinical features in combination are an indicator of evolving alpha-synucleinopathy, olfactory function was assessed in RBD. We studied 30 patients (18 male, 12 female; mean age 48 +/- 14 years, range 19-78 years) with clinical (idiopathic, n = 6; symptomatic, n = 13, mostly associated with narcolepsy) or subclinical (n = 11, associated with narcolepsy) RBD according to standard criteria and 30 age- and gender-matched healthy control subjects using standardized 'Sniffin' Sticks'. RBD patients had a significantly higher olfactory threshold (P = 0.0001), lower discrimination score (P = 0.003), and lower identification score (P = 0.001). Compared with normative data, 97% of the RBD patients had a pathologically increased olfactory threshold, 63% an impaired odour discrimination score, and 63% a decreased identification score. On neurological examination, signs of parkinsonism were newly found in five patients with clinical RBD (not associated with narcolepsy), who usually had a long history of 'idiopathic' RBD. Four of the five patients fulfilled the UK Brain Bank criteria for the clinical diagnosis of Parkinson's disease. The underlying nigrostriatal degeneration of clinical Parkinson's disease was confirmed by I-123-FP-CIT SPECT in one patient and early nigrostriatal degeneration was identified by SPECT in a further two patients with 'idiopathic' clinical RBD out of 11 RBD patients who agreed to undergo SPECT studies. Our study shows that RBD patients have a profound impairment of olfactory function. Five patients with clinical RBD not associated with narcolepsy had clinical or imaging signs of nigrostriatal degeneration. This new clinical finding correlates with the neuropathological staging of Parkinson's disease (stages 1-3) as proposed by Braak. In stage 1, the anterior olfactory nucleus or the olfactory bulb is affected (along with the dorsal motor nucleus of the glossopharyngeal and vagal nerves). In stage 2, additional lesions consistently remain confined to the medulla oblongata and pontine tegmentum, which are critical areas for RBD. Midbrain lesions are found only in stage 3, in particular degeneration of dopaminergic neurons in the substantia nigra pars compacta. Thus, 'idiopathic' RBD patients with olfactory impairment might present with stage 2 preclinical alpha-synucleinopathy. Since narcoleptic patients are not known to have an increased risk of developing parkinsonism, the pathophysiology and clinical relevance of hyposmia in RBD/narcolepsy patients requires further research.  (+info)

(6/116) Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.

Impaired rapid eye movement sleep (REMS) is commonly observed in Alzheimer's disease, suggesting injury to mesopontine cholinergic neurons. We sought to determine whether abnormal beta-amyloid peptides impair REMS and injure mesopontine cholinergic neurons in transgenic (hAPP695.SWE) mice (Tg2576) that model brain amyloid pathologies. Tg2576 mice and wild-type littermates were studied at 2, 6, and 12 months by using sleep recordings, contextual fear conditioning, and immunohistochemistry. At 2 months of age, REMS was indistinguishable by genotype but was reduced in Tg2576 mice at 6 and 12 months. Choline acetyltransferase-positive neurons in the pedunculopontine tegmentum of Tg2576 mice at 2 months evidenced activated caspase-3 immunoreactivity, and at 6 and 12 months the numbers of pedunculopontine tegmentum choline acetyltransferase-positive neurons were reduced in the Tg2576 mice. Other cholinergic groups involved in REMS were unperturbed. At 12 months, Tg2576 mice demonstrated increased 3-nitrotyrosine immunoreactivity in cholinergic projection sites but not in cholinergic soma. We have identified a population of selectively compromised cholinergic neurons in young Tg2576 mice that manifest early onset REMS impairment. The differential vulnerability of these cholinergic neurons to Abeta injury provides an invaluable tool with which to understand mechanisms of sleep/wake perturbations in Alzheimer's disease.  (+info)

(7/116) Visual hallucinations in posterior cortical atrophy.

BACKGROUND: Visual hallucinations have been reported to occur in up to 25% of patients who meet the criteria for posterior cortical atrophy (PCA). It is not known, however, whether patients who meet the criteria for PCA and have hallucinations are different from those who meet the criteria and do not have hallucinations. OBJECTIVE: To compare the clinical and imaging features of patients with PCA with and without well-formed visual hallucinations. DESIGN: Case-control study. SETTING: Tertiary care medical center. PATIENTS: Fifty-nine patients fulfilling the criteria for PCA were retrospectively identified and divided into 2 groups based on the presence (n = 13) or absence (n = 46) of visual hallucinations. MAIN OUTCOME MEASURES: Statistically significant clinical differences and imaging differences using voxel-based morphometry between the 2 groups. RESULTS: In patients with PCA and hallucinations, parkinsonism and rapid eye movement sleep behavior disorder occurred more frequently, as did myoclonic jerks (P<.001 for both). Voxel-based morphometry showed greater atrophy in a network of structures, including the primary visual cortex, lentiform nuclei, thalamus, basal forebrain, and midbrain, in patients with hallucinations. CONCLUSIONS: Hallucinations in patients with PCA are associated with parkinsonism, rapid eye movement sleep behavior disorder, and myoclonic jerks. The voxel-based morphometry results suggest that hallucinations in PCA cannot be exclusively attributed to atrophy of the posterior association cortices and may involve a circuit of thalamocortical connections.  (+info)

(8/116) Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder.

Patients with idiopathic rapid eye movement sleep behaviour disorder (RBD) frequently develop Parkinson's disease and the majority present with hyposmia, which is a potential preclinical non-motor sign of Parkinson's disease. Accordingly, it has been proposed that the clinical symptoms of hyposmia and RBD in combination have to be considered as very early symptoms of Parkinson's disease. Since not only patients with idiopathic RBD but also patients in whom RBD is associated with narcolepsy present with an olfactory dysfunction we investigated if hyposmia in RBD patients with concomitant narcolepsy is RBD specific or if narcolepsy per se is associated with olfactory dysfunction. We studied olfactory function in 20 narcoleptic patients each with RBD (9 male and 11 female; mean age 45.4 +/- 14.0 years, range 20-75 years) and without associated RBD (8 male and 12 female; mean age 44.4 +/- 13.40 years, range 20-70 years) and 40 age- and gender-matched healthy control subjects using standardized 'Sniffin' Sticks'. Both, narcoleptics with (Narc/+RBD) and without RBD (Narc/-RBD) had a significantly higher olfactory threshold (Narc/+RBD, P = 0.0001; Narc/-RBD, P = 0.0001), lower discrimination scores (P = 0.001; P = 0.014) and lower identification scores (P = 0.057; P = 0.003) than controls. There were no symptoms or signs for early parkinsonism in both patient groups. Our results show for the first time that narcolepsy per se is associated with olfactory dysfunction. In contrast to patients with idiopathic RBD, hyposmia in patients with RBD associated with narcolepsy is unlikely to be a predictor for developing parkinsonism.  (+info)



  • restless legs syn
  • It differs from Restless Legs Syndrome in that RMD involves involuntary muscle contractions before and during sleep while Restless Legs Syndrome is the urge to move before sleep. (wikipedia.org)
  • symptoms
  • Non-motor symptoms such as depression and REM sleep behavior disorder (RBD) each attribute to a particular neurodegenerative cluster in PD, and might enlighten the way for early prediction/detection of PD. (readbyqxmd.com)
  • Sedation Motor impairment Confusion Irritability and aggression Psychomotor agitation Lack of motivation Loss of libido Impaired motor function[vague]Impaired coordination Impaired balance Dizziness Cognitive impairments[vague]Hallucinations Short-term memory loss Anterograde amnesia (common with higher doses) Some users report hangover-like symptoms of drowsiness, headaches, sluggishness, and irritability upon waking up if the medication was taken before sleep. (wikipedia.org)
  • Other symptoms include sensory, sleep, and emotional problems. (wikipedia.org)
  • Evidence for treatments for the non-movement-related symptoms of PD, such as sleep disturbances and emotional problems, is less strong. (wikipedia.org)
  • Symptoms of Rhythmic Movement Disorder vary, but most sufferers share common large muscle movement patterns. (wikipedia.org)
  • Research studies have alluded to physiological behavior of the body that accounts for what causes the symptoms of RBD. (wikipedia.org)
  • Chronotypes Noise health effects Polysomnography Polysomnographic technician Reversed vegetative symptoms Sleep hygiene Sleep medicine Sleep study Sundowning (dementia) White noise machine American Academy of Sleep Medicine (2001). (wikipedia.org)
  • clinical
  • The REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) is a specific questionnaire for RBD developed by Stiasny-Kolster and team, to assess the most prominent clinical features of RBD according to the International Classification on Sleep Disorders. (wikipedia.org)
  • The feasibility of clinical interview of items adopted from the Mayo Sleep Questionnaire was also to be determined. (readbyqxmd.com)
  • REM behavior disorder is a dramatic and potentially harmful sleep disorder ," says Tracy Kuo, PhD, a sleep specialist and clinical psychologist at the Stanford Sleep Disorders Clinic in Palo Alto, Calif. "Without treatment, it tends to get worse over time. (everydayhealth.com)
  • The findings on DaTscan in subjects with these various disorders will be correlated with clinical diagnoses and other multimodal imaging studies (e.g. (clinicaltrials.gov)
  • The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials. (wikipedia.org)
  • Palsy of the vocal cords is an important and sometimes initial clinical manifestation of the disorder. (wikipedia.org)
  • violent
  • These behaviors can be violent in nature and in some cases will result in injury to either the patient or their bed partner. (wikipedia.org)
  • physiological
  • They are caused by a physiological activation in which the patient's brain exits from SWS and is caught in between a sleeping and waking state. (wikipedia.org)
  • seizures
  • Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. (wikipedia.org)
  • muscle
  • It's unknown exactly why clonazepam helps, but it's thought to suppress muscle activity during REM sleep. (everydayhealth.com)
  • Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. (wikipedia.org)
  • Because of these incessant muscle contractions, patients' sleep patterns are often disrupted. (wikipedia.org)
  • brain waves
  • It charts your brain waves, heart beat, and breathing as you sleep. (sleepeducation.org)
  • Work in oneirology overlaps with neurology and can vary from quantifying dreams, to analyzing brain waves during dreaming, to studying the effects of drugs and neurotransmitters on sleeping or dreaming. (wikipedia.org)
  • This is observed as brain waves self-firing during sleep, in slow cycles at a rate of around 14 Hz, and is believed to serve the purpose of consolidating recent memories and reinforcing old memories. (wikipedia.org)
  • syndromes
  • Several neurodegenerative disorders also may present with parkinsonism and are sometimes referred to as "atypical parkinsonism" or "Parkinson plus" syndromes (illnesses with parkinsonism plus some other features distinguishing them from PD). (wikipedia.org)
  • psychiatric
  • The purpose of this study is to investigate RBD and its relevance to Lewy body disease (LBD) in patients with late-onset psychiatric disorders. (readbyqxmd.com)
  • The American Psychiatric Association (APA) guidelines note that, in general, benzodiazepines are well tolerated, and their use for the initial treatment for panic disorder is strongly supported by numerous controlled trials. (wikipedia.org)
  • cycles
  • Normal sleep cycles include states varying from drowsiness all the way to deep sleep. (wikipedia.org)
  • There is a greater amount of deep sleep (stage N3) earlier in the night, while the proportion of REM sleep increases in the two cycles just before natural awakening. (wikipedia.org)
  • sleepiness
  • You may be asked to rate your sleep with the Epworth Sleepiness Scale. (sleepeducation.org)
  • However, other patients report that their sleep patterns are infrequently interrupted due to RMD episodes and do not report being excessively sleepy during the next day as scored on the Epworth Sleepiness Scale. (wikipedia.org)
  • normally
  • RBD may also be caused by brainstem damage of the neural circuits which normally manage the phenomenon of REM sleep. (wikipedia.org)
  • The whole period normally proceeds in the order: N1 → N2 → N3 → N2 → REM. (wikipedia.org)
  • phenomenon
  • The discovery that dreams take place primarily during a distinctive electrophysiological state of sleep (REM), which can be identified by objective criteria, led to rebirth of interest in this phenomenon. (wikipedia.org)