'Pyrans' are heterocyclic organic compounds containing a six-membered ring with one oxygen atom and five carbon atoms, which can be found in various natural substances and synthesized compounds, and may have potential applications in medicinal chemistry.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Copolymer of divinyl ether and maleic anhydride that acts as an immunostimulant with antineoplastic and anti-infective properties. It is used in combination with other antineoplastic agents.
A pyrano-acridone alkaloid found in RUTACEAE plants.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Lip diseases refer to various medical conditions that primarily affect the lips, causing symptoms such as inflammation, pain, dryness, discoloration, or abnormal growths, which may result from infectious, autoimmune, genetic, traumatic, or neoplastic causes.
A barbiturate that is effective as a hypnotic and sedative.
A double-stranded polyribonucleotide comprising polyadenylic and polyuridylic acids.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Polynucleotides are long, multiple-unit chains of nucleotides, the monomers that make up DNA and RNA, which carry genetic information and play crucial roles in various biological processes.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2. (1/742)

1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A2 (PLA2), showing selectivity for secretory PLA2 (sPLA2) versus cytosolic PLA2 (cPLA2), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2. This activity was confirmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA2 present in paw homogenates of rats with adjuvant arthritis. 3. This marine metabolite showed topical anti-inflammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg(-1). 4. In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor alpha (TNFalpha) in the exudates 4 h after the stimulus. It also had a weak effect on cell migration. 5. The inflammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not significantly affect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic effects. 6 Cacospongionolide B is a new inhibitor of sPLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation. This marine metabolite was active after oral administration and able to modify TNFalpha levels, and may offer an interesting approach in the search for new anti-inflammatory agents.  (+info)

Effects of praeruptorine C on the intracellular free calcium in normal and hypertrophied rat ventricular myocytes. (2/742)

AIM: To study the intracellular free calcium ([Ca2+]i) in normal and hypertrophic left ventricular myocytes isolated from adult rat hearts and the effects of praeruptorine C (Pra-C) on them. METHODS: [Ca2+]i of single myocyte was measured with Fura 2-AM. RESULTS: The resting [Ca2+]i was 87 +/- 4 nmol.L-1 in normal left ventricular myocytes, 123 +/- 7 nmol.L-1 in hypertrophied myocytes. After exposure to KCl (20, 40, and 60 mmol.L-1), the [Ca2+]i were increased by 66%, 141%, and 268% in normal myocytes, and 77%, 185%, and 243% in hypertrophic myocytes, respectively. Pra-C (1, 10, and 100 mumol.L-1) concentration-dependently inhibited the [Ca2+]i elevation caused by KCl (35 mmol.L-1) or norepinephrine (20 mumol.L-1) in both normal and hypertrophied myocytes. All of the effects of Pra-C were similar to that of nifedipine. CONCLUSION: [Ca2+]i of hypertrophied myocytes was higher than that of normal ones and Pra-C decrease the [Ca2+]i elevation in left ventricular myocytes resulted from its calcium channel blockade.  (+info)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (3/742)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

New actin mutants allow further characterization of the nucleotide binding cleft and drug binding sites. (4/742)

We have generated 9 site-specific mutations in Saccharomyces cerevisiae actin. These mutants display a variety of phenotypes when expressed in vivo, including slow actin filament turnover, slow fluid-phase endocytosis, and defects in actin organization. Actin mutation D157E confers resistance to the actin-sequestering drug, latrunculin A. Latrunculin A inhibits nucleotide exchange on wild-type yeast actin but not on D157E actin, suggesting that this residue is part of the latrunculin A binding site. We have refined our earlier map of the phalloidin binding site on actin, demonstrating a requirement for residue G158 in addition to D179 and R177. The nine new actin mutants as well as a large collection of existing actin mutants were also used to identify the putative binding site of another actin binding drug, tolytoxin, on actin. The actin alleles that result in decreased sensitivity to this drug cluster at a site near the nucleotide-binding pocket. Actin purified from one of these mutants has a reduced affinity for tolytoxin. In addition, tolytoxin causes a 2.4-fold increase in the t1/2 of ATP exchange, further suggesting that this drug binds near the nucleotide-binding pocket of actin. We note that the binding sites for latrunculin A, phalloidin, and tolytoxin all map close to the actin nucleotide binding pocket.  (+info)

Reactivity of Cl-P(+)-Cl toward cyclic organic ethers. (5/742)

The dichlorophosphenium ion (Cl-P(+)-Cl) undergoes a variety of reactions with cyclic organic ethers in the gas phase in a Fourier-transform ion cyclotron resonance mass spectrometer. Most of the reactions are initiated by Cl-P(+)-Cl-induced heterolytic C-O bond cleavage. However, the observed final products depend on the exact structure of the ether. For saturated ethers, e.g., tetrahydropyran, tetrahydrofuran, and 2-methyltetrahydrofuran, the most abundant ionic product corresponds to hydroxide abstraction by Cl-P(+)-Cl. This unexpected reaction is rationalized by a multistep mechanism that involves an initial heterolytic C-O bond cleavage accompanied by a 1,2-hydride shift, and that ultimately yields a resonance-stabilized allyl cation and HOPCl2. The process is estimated to be highly exothermic (AM1 calculations yield delta H = -(33-38) kcal mol(-1) for the ethers mentioned above). However, the adducts formed from most of the unsaturated ethers are unable to undergo hydride shifts and hence cannot react via this pathway. In some of these cases, e.g., for 2,5-dihydrofuran and 2,5-dihydro-3,4-benzofuran, the C-O bond heterolysis is followed by oxygen/chlorine exchange to yield the O=PCl radical and a resonance-stabilized carbocation (AM1 calculations yield delta H = -14 kcal mol(-1) for the reaction of 2,5-dihydro-3,4-benzofuran). Hydride abstraction by Cl-P(+)-Cl also yields an abundant product for these two ethers. On the other hand, the ethers with low ionization energies, such as 2,3-dihydrofuran and 2,3-dihydrobenzofuran, react with Cl-P(+)-Cl by electron transfer. Finally, a unique pathway, addition followed by elimination of HCl, dominates the reaction with furan. The observed reactions are rationalized by thermochemical data obtained from semiempirical molecular orbital calculations.  (+info)

Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55. (6/742)

The intermediate filament protein vimentin is a major phosphoprotein in mammalian fibroblasts, and reversible phosphorylation plays a key role in its dynamic rearrangement. Selective inhibition of type 2A but not type 1 protein phosphatases led to hyperphosphorylation and concomitant disassembly of vimentin, characterized by a collapse into bundles around the nucleus. We have analyzed the potential role of one of the major protein phosphatase 2A (PP2A) regulatory subunits, B55, in vimentin dephosphorylation. In mammalian fibroblasts, B55 protein was distributed ubiquitously throughout the cytoplasm with a fraction associated to vimentin. Specific depletion of B55 in living cells by antisense B55 RNA was accompanied by disassembly and increased phosphorylation of vimentin, as when type 2A phosphatases were inhibited using okadaic acid. The presence of B55 was a prerequisite for PP2A to efficiently dephosphorylate vimentin in vitro or to induce filament reassembly in situ. Both biochemical fractionation and immunofluorescence analysis of detergent-extracted cells revealed that fractions of PP2Ac, PR65, and B55 were tightly associated with vimentin. Furthermore, vimentin-associated PP2A catalytic subunit was displaced in B55-depleted cells. Taken together these data show that, in mammalian fibroblasts, the intermediate filament protein vimentin is dephosphorylated by PP2A, an event targeted by B55.  (+info)

Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection. (7/742)

Zanamivir is a potent inhibitor of influenza A and B virus neuraminidases and is active topically in experimental and natural human influenza. We conducted this double-blinded, placebo-controlled study to evaluate the safety and efficacy of intravenously administered zanamivir. Susceptible volunteers were randomized to receive either saline or zanamivir (600 mg) intravenously twice daily for 5 days beginning 4 h prior to intranasal inoculation with approximately 10(5) 50% tissue culture infectious doses (TCID50) of influenza A/Texas/36/91 (H1N1) virus. Reductions in the frequency of viral shedding (0% versus 100% in placebo, P < 0.005) and seroconversion (14% versus 100% in placebo, P < 0.005) and decreases in viral titer areas under the curve (0 versus 11.6 [median] log10 TCID50. day/ml in placebo, P < 0.005) were observed in the zanamivir group, as were reductions in fever (14% versus 88% in placebo, P < 0.05), upper respiratory tract illness (0% versus 100% in placebo, P < 0.005), total symptom scores (1 versus 44 [median] in placebo, P < 0.005), and nasal-discharge weight (3.9 g versus 17.5 g [median] in placebo, P < 0.005). Zanamivir was detectable in nasal lavage samples collected on days 2 and 4 (unadjusted median concentrations, 10.5 and 12.0 ng/ml of nasal wash, respectively). This study demonstrates that intravenously administered zanamivir is distributed to the respiratory mucosa and is protective against infection and illness following experimental human influenza A virus inoculation.  (+info)

Efficacy and safety of the neuraminidase inhibitor zanamivirin the treatment of influenza A and B virus infections. (8/742)

The efficacy and safety of zanamivir, administered 2x or 4x daily over 5 days, was evaluated in the treatment of influenza infections. A total of 1256 patients entered the study; 57% of those randomized had laboratory-confirmed influenza infection. The primary end point, "alleviation of major symptoms," was created to evaluate differences in clinical impact. In the overall population with or without influenza infection, zanamivir reduced the median number of days to reach this end point by 1 day (P=.012 2x daily vs. placebo; P=.014 4x daily vs. placebo). The reduction was greater in patients treated within 30 h of symptom onset, febrile at study entry, and in defined high-risk groups. Zanamivir reduced nights of disturbed sleep, time to resumption of normal activities, and use of symptom relief medications. It was well tolerated. These results suggest that zanamivir can significantly reduce the duration and overall symptomatic effect of influenza.  (+info)

"Pyrans" is not a term commonly used in medical definitions. It is a chemical term that refers to a class of heterocyclic compounds containing a six-membered ring with one oxygen atom and five carbon atoms. The name "pyran" comes from the fact that it contains a pyroline unit (two double-bonded carbons) and a ketone group (a carbon double-bonded to an oxygen).

While pyrans are not directly related to medical definitions, some of their derivatives have been studied for potential medicinal applications. For example, certain pyran derivatives have shown anti-inflammatory, antiviral, and anticancer activities in laboratory experiments. However, more research is needed before these compounds can be considered as potential therapeutic agents.

Cyclization is a chemical process that involves forming a cyclic structure or ring-shaped molecule from a linear or open-chain compound. In the context of medicinal chemistry and drug design, cyclization reactions are often used to synthesize complex molecules, including drugs, by creating rings or fused ring systems within the molecule's structure.

Cyclization can occur through various mechanisms, such as intramolecular nucleophilic substitution, electrophilic addition, or radical reactions. The resulting cyclized compounds may exhibit different chemical and biological properties compared to their linear precursors, making them valuable targets for drug discovery and development.

In some cases, the cyclization process can lead to the formation of stereocenters within the molecule, which can impact its three-dimensional shape and how it interacts with biological targets. Therefore, controlling the stereochemistry during cyclization reactions is crucial in medicinal chemistry to optimize the desired biological activity.

Overall, cyclization plays a significant role in the design and synthesis of many pharmaceutical compounds, enabling the creation of complex structures that can interact specifically with biological targets for therapeutic purposes.

Pyran copolymer is not a medical term per se, but it is a chemical compound that has been used in the medical field, particularly in the development of some medications and medical devices.

Pyran copolymer is a synthetic polymer made up of repeating units of furan and maleic anhydride. It is known for its biocompatibility, making it useful in medical applications such as drug delivery systems and implantable devices. The compound has been explored for its potential to reduce the risk of infection and inflammation in these settings.

In summary, pyran copolymer is a synthetic polymer made up of furan and maleic anhydride repeating units, which has been used in medical applications due to its biocompatibility and potential to reduce the risk of infection and inflammation.

I'm not aware of a medical definition for the term "Acronine." It is possible that it could be a brand name or a specialized term used within a specific context in medicine or science. However, without more information, I cannot provide an accurate definition. In general, Acronine is not a widely recognized or commonly used term in the field of medicine.

In the context of medical definitions, polymers are large molecules composed of repeating subunits called monomers. These long chains of monomers can have various structures and properties, depending on the type of monomer units and how they are linked together. In medicine, polymers are used in a wide range of applications, including drug delivery systems, medical devices, and tissue engineering scaffolds. Some examples of polymers used in medicine include polyethylene, polypropylene, polystyrene, polyvinyl chloride (PVC), and biodegradable polymers such as polylactic acid (PLA) and polycaprolactone (PCL).

Lip diseases refer to various medical conditions that affect the lips, which can be caused by different factors such as infections, inflammation, allergies, or autoimmune disorders. Some examples of lip diseases include:

1. Cheilitis: It is an inflammation of the lips, which can cause dryness, cracking, and soreness. It can be caused by various factors, including irritants, allergies, or infections.
2. Angular cheilitis: It is a condition that causes inflammation and redness at the corners of the mouth. It can be caused by fungal or bacterial infections, ill-fitting dentures, or vitamin deficiencies.
3. Herpes simplex labialis: Also known as cold sores, it is a viral infection that causes painful blisters on the lips and around the mouth. The virus can be spread through close contact with an infected person.
4. Actinic cheilitis: It is a precancerous condition caused by excessive exposure to the sun, which leads to dry, scaly, or thickened patches on the lips.
5. Fordyce spots: These are small, painless, white or yellowish bumps that appear on the lips and inside the mouth. They are harmless and do not require treatment.
6. Lip cancer: It is a type of skin cancer that affects the lips, usually caused by excessive exposure to the sun. The symptoms include a sore or lump on the lip that does not heal, bleeding, pain, or numbness.

If you experience any symptoms related to lip diseases, it is recommended to consult a healthcare professional for proper diagnosis and treatment.

Hexobarbital is a medication that belongs to the class of drugs called barbiturates. It is primarily used as a short-acting sedative and hypnotic agent, which means it can help induce sleep and reduce anxiety. Hexobarbital works by depressing the central nervous system, slowing down brain activity and causing relaxation and drowsiness.

It's important to note that hexobarbital is not commonly used in modern medical practice due to the availability of safer and more effective alternatives. Additionally, barbiturates like hexobarbital have a high potential for abuse and dependence, and their use is associated with several risks, including respiratory depression, overdose, and death, particularly when taken in combination with other central nervous system depressants such as alcohol or opioids.

"Poly A-U" is not a standard medical term. However, in biochemistry and genetics, "poly A" and "poly U" refer to repeating sequences of adenine (A) or uracil (U) nucleotides in DNA or RNA molecules, respectively.

"Poly A" is a post-transcriptional modification that occurs in mRNA, where multiple adenine nucleotides are added to the 3' end of the transcript. This process is important for the stability and translation of mRNA in eukaryotic cells.

"Poly U," on the other hand, can be found in some RNA molecules such as in the 3' untranslated region (UTR) of certain mRNAs or in specific types of non-coding RNAs like U-rich small nuclear RNAs (snRNAs).

Therefore, "Poly A-U" may refer to alternating sequences of adenine and uracil nucleotides in a DNA or RNA molecule. However, it is essential to consider the context in which this term is used to provide an accurate interpretation.

Bryostatins are a class of naturally occurring marine-derived macrolide lactones that have been isolated from the Bugula neritina, a species of bryozoan. These compounds have attracted significant interest in the medical community due to their potent bioactivities, particularly their ability to modulate various signaling pathways involved in cancer, inflammation, and neurological disorders.

One of the most notable properties of bryostatins is their capacity to act as protein kinase C (PKC) agonists. PKC is a family of enzymes that play critical roles in various cellular processes, including cell growth, differentiation, and apoptosis. By activating PKC, bryostatins can induce differentiation and inhibit proliferation of certain types of cancer cells, making them promising candidates for anti-cancer therapy.

In addition to their effects on PKC, bryostatins have also been shown to modulate other signaling pathways, such as the nuclear factor kappa B (NF-κB) and Akt pathways, which are involved in inflammation and cell survival. These pleiotropic effects make bryostatins interesting targets for the development of novel therapeutic strategies for a range of diseases.

Despite their promising potential, the clinical application of bryostatins has been limited by their low natural abundance and challenging chemical synthesis. Nevertheless, ongoing research efforts continue to explore new methods for large-scale production and optimization of these compounds, with the ultimate goal of harnessing their unique biological activities for medical benefit.

Experimental leukemia refers to the stage of research or clinical trials where new therapies, treatments, or diagnostic methods are being studied for leukemia. Leukemia is a type of cancer that affects the blood and bone marrow, leading to an overproduction of abnormal white blood cells.

In the experimental stage, researchers investigate various aspects of leukemia, such as its causes, progression, and potential treatments. They may conduct laboratory studies using cell cultures or animal models to understand the disease better and test new therapeutic approaches. Additionally, clinical trials may be conducted to evaluate the safety and efficacy of novel treatments in human patients with leukemia.

Experimental research in leukemia is crucial for advancing our understanding of the disease and developing more effective treatment strategies. It involves a rigorous and systematic process that adheres to ethical guidelines and scientific standards to ensure the validity and reliability of the findings.

"Spiro compounds" are not specifically classified as medical terms, but they are a concept in organic chemistry. However, I can provide a general definition:

Spiro compounds are a type of organic compound that contains two or more rings, which share a single common atom, known as the "spiro center." The name "spiro" comes from the Greek word for "spiral" or "coiled," reflecting the three-dimensional structure of these molecules.

The unique feature of spiro compounds is that they have at least one spiro atom, typically carbon, which is bonded to four other atoms, two of which belong to each ring. This arrangement creates a specific geometry where the rings are positioned at right angles to each other, giving spiro compounds distinctive structural and chemical properties.

While not directly related to medical terminology, understanding spiro compounds can be essential in medicinal chemistry and pharmaceutical research since these molecules often exhibit unique biological activities due to their intricate structures.

Stereoisomerism is a type of isomerism (structural arrangement of atoms) in which molecules have the same molecular formula and sequence of bonded atoms, but differ in the three-dimensional orientation of their atoms in space. This occurs when the molecule contains asymmetric carbon atoms or other rigid structures that prevent free rotation, leading to distinct spatial arrangements of groups of atoms around a central point. Stereoisomers can have different chemical and physical properties, such as optical activity, boiling points, and reactivities, due to differences in their shape and the way they interact with other molecules.

There are two main types of stereoisomerism: enantiomers (mirror-image isomers) and diastereomers (non-mirror-image isomers). Enantiomers are pairs of stereoisomers that are mirror images of each other, but cannot be superimposed on one another. Diastereomers, on the other hand, are non-mirror-image stereoisomers that have different physical and chemical properties.

Stereoisomerism is an important concept in chemistry and biology, as it can affect the biological activity of molecules, such as drugs and natural products. For example, some enantiomers of a drug may be active, while others are inactive or even toxic. Therefore, understanding stereoisomerism is crucial for designing and synthesizing effective and safe drugs.

Polynucleotides are long, chain-like molecules composed of repeating units called nucleotides. Each nucleotide contains a sugar molecule (deoxyribose in DNA or ribose in RNA), a phosphate group, and a nitrogenous base (adenine, guanine, cytosine, thymine in DNA or adenine, guanine, uracil, cytosine in RNA). In DNA, the nucleotides are joined together by phosphodiester bonds between the sugar of one nucleotide and the phosphate group of the next, creating a double helix structure. In RNA, the nucleotides are also joined by phosphodiester bonds but form a single strand. Polynucleotides play crucial roles in storing and transmitting genetic information within cells.

Alkenes are unsaturated hydrocarbons that contain at least one carbon-carbon double bond in their molecular structure. The general chemical formula for alkenes is CnH2n, where n represents the number of carbon atoms in the molecule.

The double bond in alkenes can undergo various reactions, such as addition reactions, where different types of molecules can add across the double bond to form new compounds. The relative position of the double bond in the carbon chain and the presence of substituents on the carbon atoms can affect the physical and chemical properties of alkenes.

Alkenes are important industrial chemicals and are used as starting materials for the synthesis of a wide range of products, including plastics, resins, fibers, and other chemicals. They are also found in nature, occurring in some plants and animals, and can be produced by certain types of bacteria through fermentation processes.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

In 2H-pyran, the saturated carbon is at position 2, whereas, in 4H-pyran, the saturated carbon is at position 4. 4H-Pyran was ... The term pyran is also often applied to the saturated ring analog, which is more properly referred to as tetrahydropyran (oxane ... In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one ... 4H-pyran easily disproportionates to the corresponding dihydropyran and the pyrylium ion, which is easily hydrolyzed in aqueous ...
Piran or Pyran (Cornish: Peran; Latin: Piranus), died c. 480, was a 5th-century Cornish abbot and saint, possibly of Irish ... Piran (Pyran) March 5. Orthodox England on the 'net (St John's Orthodox Church, Colchester). Retrieved: 15 September 2015. ...
Structurally, they are bicyclic cis-fused cyclopentane-pyrans. Cleavage of a bond in the cyclopentane ring gives rise to a ...
Pyran Tetrahydropyran Paul Ch. Kierkus (2001). "3,4‐Dihydro‐2H‐pyran". eEROS. doi:10.1002/047084289X.rd230. R. L. Sawyer and D ...
"2H-Pyran-2-one, 6-pentyl-". webbook.nist.gov. Kalyani, A; Prapulla, SG; Karanth, NG (May 2000). "Study on the production of 6- ... "6-Pentyl-2H-pyran-2-one". pubchem.ncbi.nlm.nih.gov. Alam, Md. Imteyaz; Gupta, Shelaka; Bohre, Ashish; Ahmad, Ejaz; Khan, Tuhin ...
The average Pyran lives about 300 years. Kulai is 342 and has an extended lifespan which is a part of the unique abilities with ... Pyrans share a common psychic bond, a sense of shared existence. The presence of a Chalim generates a critical element of the ... Without a Chalim, the Pyran race would lack a crucial psychic catalyst. No matter where she is, Kulai can sense whether or not ... led by the Pyran traitor, Paiyin. The sole purpose of the Triiad is to wipe out intelligent races, and in the process acquire ...
Synthesis of Isochromanes and Related Pyran-Type Heterocycles". Synthesis (2): 187-210. doi:10.1055/s-2005-918502. Yokoyama, ...
1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans]". Journal of Medicinal Chemistry. 51 (20): 6531-6537. doi:10.1021/ ... pyran]: putative antagonist, selective against 5-HT1A, 5-HT6, 5-HT7, α1A and α2 adrenergic, and NMDA receptors NE-100 Positive ...
It is a metal-mediated rearrangement of enol ether pyrans to cyclohexanones. Typically, this reaction is catalyzed by mercury ...
So there is a carbon atom which is common on both rings, the pyran ring and the replaced ring. The second ring, the replaced ... CS1 errors: periodical ignored, CS1 errors: missing title, Spiro compounds, Pyrans, Photochemistry). ... A spiropyran is a 2H-pyran isomer that has the hydrogen atom at position two replaced by a second ring system linked to the ... carbon atom at position two of the pyran molecule in a spiro way. ...
Longley Jr., R. I..; Emerson, W. S.; Blardinelli, A. J. (1954). "3,4-Dihydro-2-methoxy-4-methyl-2H-pyran". Org. Synth. 34: 29. ...
... , like all iridoids, has a cyclopentan-[C]-pyran skeleton. Iridoids can consist of ten, nine, or rarely eight carbons in ... The cyclization reaction to form the iridoid pyran ring may result from one of two routes: route 1 - a hydride nucleophillic ... Nangia A, Prasuna G, Rao P (1997). "Synthesis of cyclopenta[c]pyran skeleton of iridoid lactones". Tetrahedron. 53 (43): 14507- ...
Wang, Zhiying; Fu, Peng; Liu, Peipei; Wang, Pei; Hou, Jiabo; Li, Wenjun; Zhu, Weiming (February 2013). "New Pyran-2-ones from ...
This molecule has a phenanthro[4,5-bcd]pyran structure. Majumder, Priyalal; Bandyopadhyay, Debabrata; Joardar, Subhendu (1982 ...
3.0.CO;2-W. Keck, Gary E.; Covel, Jonathan A.; Schiff, Tobias; Yu, Tao (2002). "Pyran Annulation: Asymmetric Synthesis of 2,6- ...
... is a heterocyclic organic acid with a pyran skeleton. Chelidonic acid can be prepared in two steps from diethyl ...
The pyranoflavonoids are a type of flavonoids possessing a pyran group. Cyclocommunin is another natural pyranoflavonoid. ...
"Convergent and diastereoselective synthesis of the polycyclic pyran core of saudin" (PDF). The Journal of Organic Chemistry. 71 ...
... is an organic compound of the pyran class of monoterpenes. The compound has a cis- and a trans-isomer, each with a ...
... s are analogous to pyrans in which the oxygen atoms have been replaced by sulfur atoms. Thiopyrylium Thio- Kuthan, J ...
1. 1-Amino- and 1-mercapto-7,8,9,10-tetrahydro-6H-dibenzo [b,d]pyrans". Journal of Medicinal Chemistry. 20 (1): 17-24. doi: ...
... s are a class of chemical compounds that have a core structure that consists of a pyran ring fused to a coumarin ... v t e (Pyrans, Coumarins, Heterocyclic compounds with 3 rings, All stub articles, Organic compound stubs). ... In the biosyntheses of pyranocoumarins, the pyran ring is formed via the methylerythritol phosphate pathway and the coumarin is ...
Majeski, J. A.; Stinnett, J. D. (March 1977). "Chemoattractant properties of Corynebacterium parvum and pyran copolymer for ...
The epoxide of PA-A at C10-11 is believed to be inserted after pyran formation by a cytochrome P450 such as MupO. A gene ... The formation of the pyran ring requires many enzyme-mediated steps (Figure 4). The double bond between C8 and C9 is proposed ... A knockout of mupW eliminated the pyran ring, identifying MupW as being involved in ring formation. ...
The name Polperro derives from the Cornish Porthpyra, meaning harbour named after Pyran. However Ekwall suggests that "Pyra" or ...
Pyrone 2H-Pyran-2-one at Sigma-Aldrich Woodard BT, Posner G H (1999). "Recent Advances in Diels-Alder Cycloadditions Using 2- ... 2-Pyrone (α-pyrone or pyran-2-one) is an unsaturated cyclic chemical compound with the molecular formula C5H4O2. It is isomeric ...
... (γ-pyrone or pyran-4-one) is an unsaturated cyclic chemical compound with the molecular formula C5H4O2. It is isomeric ... Pyrone 4-Pyridone Dehydroacetic acid 4H-Pyran-4-one at Sigma-Aldrich Weygand, Conrad (1972). Hilgetag, G.; Martini, A. (eds.). ...
Stokker, Gerald E (January 1987). "Palladium catalyzed stereospecific Michael arylation of 6-alkyl-5,6-dihydro-2H-pyran-2-ones ...
The systematic name of this enzyme is 2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase. This enzyme is found to play an ... The enzyme 2-pyrone-4,6-dicarboxylate lactonase (EC 3.1.1.57, LigI) catalyzes the reversible hydrolytic reaction 2-oxo-2H-pyran ...
Tanabe, Masato; Peters, Richard H. (1981). "(R,S)-Mevalonolactone-2-13C (2H-Pyran-2-one-13C, tetrahydro-4-hydroxy-4-methyl-)". ...
In 2H-pyran, the saturated carbon is at position 2, whereas, in 4H-pyran, the saturated carbon is at position 4. 4H-Pyran was ... The term pyran is also often applied to the saturated ring analog, which is more properly referred to as tetrahydropyran (oxane ... In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one ... 4H-pyran easily disproportionates to the corresponding dihydropyran and the pyrylium ion, which is easily hydrolyzed in aqueous ...
... -. *Formula: C5H8O2 ... Tetrahydro-2H-pyran-2-one; Delta-valerolactone; δ-Pentalactone ...
Other names: 6-Amyl-α-pyrone; Pyran-2-one, 6-pentyl-; 6-N-Amyl α-pyrone; 6-Pentyl-2H-pyran-2-one; α-Pyrone, 6-pentyl; 2-Pyrone ... 2H-Pyran-2-one, 6-pentyl-. *Formula: C10H14O2 ...
SCHOTT PYRAN® Platinum Fire-Rated Glass-Ceramic product variants offer impact resistance as well as fire protection for up to ... PYRAN® Platinum is available as three different products: the monolithic glass-ceramic PYRAN® Platinum, the laminated PYRAN® ... PYRAN® Platinum. PYRAN® Platinum fire-rated glazing material is made from the worlds first and only floated transparent glass- ... PYRAN® Platinum F. Ideal for safety-rated locations such as windows, door lites, transoms and sidelites, PYRAN® Platinum F ...
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Be the first to review "3,4-Dihydro-2H-Pyran-2-methanol" Cancel reply. Your rating *. Rate…. Perfect. Good. Average. Not that ...
In his text, J. E. Smith describes Pyran as one of the most favourite water-falls and explains how it terminates an umbrageous ... A picturesque view of the Pyran falls near Hafod House from Tour to Hafod, a fine collection of plates depicting the mansion ... Upper part of the Pyran Cascade. [Pl. 6] London: Published by White and Co., 1810. Hand-coloured aquatint engraving. Very good ... A picturesque view of the Pyran falls near Hafod House from "Tour to Hafod," a fine collection of plates depicting the mansion ...
... tetrahydro-2H-pyran-2-yl (1Z)-4-hydroxy-N-(sulfooxy)butanimido. ... ahydro-2H-pyran-2-y. l (1Z)-4-hydroxy-N-. (sulfooxy)butanimid. ... hyl)tetrahydro-2H-pyran-2-yl (. 1Z)-4-hydroxy-N-(sulfooxy)buta. nimidothioate *Molecular FormulaC10H19NO10S2 ... ahydro-2H-pyran-2-y. l-(1Z)-4-hydroxy-N-. (sulfooxy)butanimid. othioat [German] [ACD/IUPAC Name] ... pyran-2-yle [French] [ACD/IUPAC Name] 4,5,6-Trihydroxy-3-. (hydroxymethyl)tetr. ...
2-Ethyl-4-isopropyl-2-methyltetrahydro-2H-pyran-4-yl]ethyl}amino)methyl]-N,N-dim. ... 2H-Pyran-4-ethanami. ne, N-[[4-(dimethyl. amino)phenyl]methyl. ]-2-ethyltetrahydro. -2-methyl-4-(1-meth. ylethyl)-, (2S,4S)- [ ... pyran-4-yl]éthyl}a. mino)méthyl]-N,N-di. méthylaniline [French] [ACD/IUPAC Name] ... pyran-4-yl]ethyl}a. mino)methyl]-N,N-di. methylanilin [German] [ACD/IUPAC Name] ...
[1398504-24-9], MFCD22573664, Cis-ethyl 3-aminotetrahydro-2h-pyran-4-carboxylate tfa
3-methylenetetrahydro-2H-pyran-2-one - C6H8O2, synthesis, structure, density, melting point, boiling point ... Tags: melting point of 3-methylenetetrahydro-2H-pyran-2-one , boiling point of 3-methylenetetrahydro-2H-pyran-2-one , density ... of 3-methylenetetrahydro-2H-pyran-2-one , refractive index of 3-methylenetetrahydro-2H-pyran-2-one ...
2R)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4-piperidine]-1-yl)propanamide , ...
Z Werb, J R Chin; Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran ... Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or ... pyran copolymer, whole Corynebacterium parvum, or bacterial endotoxin. ApoE represented approximately 1% of the newly ...
Thienopyrans / Thiophene carboxylic acids / N-arylamides / Pyrans / Dicarboxylic acids and derivatives / Vinylogous amides / ... 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid. DrugBank Accession Number. DB03102. Background. Not ... 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid. ... Structure for 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid (DB03102). ×. ...
one-pot synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromenes in moderate. to excellent yields and under eco- ... One-pot synthesis of tetrahydrobenzo[b]pyran and dihydropyrano[c]chromene derivatives in aqueous media by using trisodium ...
Madison renewable chemicals startup, Pyran Inc., seeks first commercial plant. Renewable chemicals startup Pyran Inc. of ...
VIO Chemicals offers Tetrahydro-4H-Pyran-4-one ...
Pyran, Inc., a high-growth company that creates high-performing 5-carbon products made from renewable resources, today ... Pyran uses renewable feedstocks from crop resources, such as corn cobs, to make 1,5- pentanediol (PDO) - a key ingredient that ... Pyran, Inc., a high-growth company that creates high-performing 5-carbon products made from renewable resources, today ... Pyrans renewable-based, on-purpose production will enable customers to expand their businesses with better performing and more ...
PYRAN® FUSION glazing is resistant to extreme temperatures and retains outstanding transparency. It can be vital in the event ... FLAMESHIELD SCHOTT PYRAN® Fusion : Interlayered, heat-treated fire-rated glass. *FLAMESHIELD SCHOTT PYRAN® Fusion COMBI : ... One of our latest innovations, PYRAN® Fusion is manufactured with path-breaking materials to meet the most exacting worldwide ...
Hesam Dashti, Jonathan R. Wedell, William M. Westler, Marco Tonelli, David Aceti, Gaya K. Amarasinghe, John L. Markley, and Hamid R. Eghbalnia, Applications of Parametrized NMR Spin Systems of Small Molecules, Anal. Chem., 2018, 90 (18), pp 10646-10649, DOI: 10.1021/acs.analchem.8b02660 ...
α-Alkoxystannanes as masked oxonium ions: application to the synthesis of furo[2,3-b]pyrans. Tetrahedron Letters. 2006 May 22; ... α-Alkoxystannanes as masked oxonium ions: application to the synthesis of furo[2,3-b]pyrans. In: Tetrahedron Letters. 2006 ; ... α-Alkoxystannanes as masked oxonium ions: application to the synthesis of furo[2,3-b]pyrans. / Attwood, Michael R.; Gilbert, ... Dive into the research topics of α-Alkoxystannanes as masked oxonium ions: application to the synthesis of furo[2,3-b]pyrans ...
Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics. In: Tetrahedron Letters. 1984 ; Vol. 25, No. 30. pp. ... Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics. / Semmelhack, Martin F.; Bodurow, Christina; Baum, ... Semmelhack MF, Bodurow C, Baum M. Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics. Tetrahedron Letters ... Semmelhack, M. F., Bodurow, C., & Baum, M. (1984). Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics. ...
3,3-Dimethyldihydro-2H-pyran-2,6(3H)-dione. Product ID BD64575 ... Product Name 3,3-Dimethyldihydro-2H-pyran-2,6(3H)-dione CAS No. ...
National Guard Products Model L-FRA100 with Pyran Platinum - F, Fire Protective Safety Ceramic Glass, Fire Door Window Kit, ... Price includes Pyran Platinum F Fire Protective Safety Glass Ceramic and GT-118 Glazing Tape installed for fire ratings up to ... National Guard Products Door Window Lite, Model L-FRA100 with Pyran Platinum - F Fire Protective Safety Ceramic Glass. Low ... National Guard Products Steel Door Window Lite, Model L-FRA100 with Pyran Platinum - F, Fire Protective Safety Ceramic Glass. ...
Barker, Thomas A (2012) PALLADIUM-CATALYZED [1,3] O→C REARRANGEMENT OF PYRANS TOWARDS FUNCTIONALIZED CYCLOHEXANONES. PhD thesis ... PALLADIUM-CATALYZED [1,3] O→C REARRANGEMENT OF PYRANS TOWARDS FUNCTIONALIZED CYCLOHEXANONES ...
5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE. Find entries where: KOJ. is present as a standalone ligand in 5 entries ...
4-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Phenyl)Boronic Acid with CAS No.182281-01-2 ...
3-methyl-2H-furo(2,3-c)pyran-2-one * Arabidopsis Proteins ...
  • Trisodium citrate, a natural non-toxic compound, is used as a catalyst for an efficient, rapid, one-pot synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromenes in moderate to excellent yields and under eco-friendly conditions. (scholarsresearchlibrary.com)
  • Synthesis of 3,6-Dihydro-2 H -pyran Subunits of Laulimalide Using Olefinic Ring Closing Metathesis. (nsmsi.ir)
  • An expeditious synthesis of unsymmetrical biaryls functionalized with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation of 2 H -pyran-2-one using acetyltrimethylsilane (ATMS) as a novel reagent in good yield. (figshare.com)
  • Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages. (rupress.org)
  • We have found that apoprotein E (ApoE), a component of plasma lipoproteins, was synthesized and secreted by resident and nonspecifically stimulated macrophages elicited with thioglycollate broth, but not by activated macrophages obtained from mice treated with bacillus Calmette-Guerin, pyran copolymer, whole Corynebacterium parvum, or bacterial endotoxin. (rupress.org)
  • Renewable chemicals startup Pyran Inc. of Madison is currently looking to open its first commercial plant, as discussed in a WisconsinInno article. (wisinvpartners.com)
  • Pyran, Inc., a high-growth company that creates high-performing 5-carbon products made from renewable resources, today announced that it has closed its latest round of fundraising, bringing its total of investments and grants to nearly $4 million. (wisc.edu)
  • Pyran uses renewable feedstocks from crop resources, such as corn cobs, to make 1,5- pentanediol (PDO) - a key ingredient that enhances the performance of everyday materials, such as paints, coatings, adhesives and more. (wisc.edu)
  • 4H-pyran easily disproportionates to the corresponding dihydropyran and the pyrylium ion, which is easily hydrolyzed in aqueous medium. (wikipedia.org)
  • PYRAN® Platinum L and F offer high impact resistance alongside protection from fire, hot gases and smoke. (schott.com)
  • In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one oxygen atom and containing two double bonds. (wikipedia.org)
  • Although the pyrans themselves have little significance in chemistry, many of their derivatives are important biological molecules, such as the pyranoflavonoids. (wikipedia.org)
  • PYRAN® Platinum fire-rated glazing material is made from the world's first and only floated transparent glass-ceramic. (schott.com)
  • Furthermore, the crystal structure contains one mol-ecule of DMF, which accepts two O-H⋯H hydrogen bonds from the OH groups of the gluco-pyran-oside. (iucr.org)
  • A picturesque view of the Pyran falls near Hafod House from "Tour to Hafod," a fine collection of plates depicting the mansion and its surrounding landscape engraved by Stadler after drawings by Smith. (donaldheald.com)
  • gives an alternative view of the cation, indicating the distinctive chair conformation of the gluco-pyran-oside as well as the overall stereochemistry of the compound. (iucr.org)
  • PYRAN® Platinum is available as three different products: the monolithic glass-ceramic PYRAN® Platinum, the laminated PYRAN® Platinum L, and PYRAN® Platinum F, which features a surface-applied film. (schott.com)
  • One of our latest innovations, PYRAN® Fusion is manufactured with path-breaking materials to meet the most exacting worldwide fire-safety standards. (fgglass.com)
  • Ideal for safety-rated locations such as windows, door lites, transoms and sidelites, PYRAN® Platinum F features a surface-applied safety film that adds impact resistance to outstanding heat resistance. (schott.com)
  • With the same thickness, sheet size, fire rating and stunning appearance as PYRAN® Platinum, this variant adds an extra layer of safety to your doors and windows. (schott.com)
  • Get chemical information updates for 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole sent to your email. (chemchart.com)
  • S-Deoxo-3,17β-bis-(O-tetrahydro-2H-pyran-2-yl)-6-oxo-fulvestrant product with CAS: 862700-70-7 is related to Fulvestrant. (synthinkchemicals.com)
  • Moreover, 7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfenyl]nonyl]-3,17β-bis-(O-tetrahydro-2H-pyran-2-yl)estra-1,3,5(10)-triene-6-one is also used in the process of Abbreviated New Drug Application (ANDA) filing to FDA and toxicity study of respective drug formulation. (synthinkchemicals.com)
  • The SCHOTT PYRAN® Star range of fire-rated glass-ceramics have similarly impressive credentials. (schott.com)
  • Due to several fire tests with SCHOTT PYRAN® S, the 5 mm smoke screen allows multiple mounting setups. (schott.com)
  • 8-Amino-1-methoxy-6H-dibenzo[b,d]pyran-6-one was synthesized in a one-pot reaction of 2′,6′-dimethoxy-4-nitro-1,1′-biphenyl-2-carboxylic acid methyl ester using hydroiodic acid as a reagent to effect O-demethylation, lactonization, and nitro reduction to amine. (schk.sk)
  • The structure of 4-methyl-3-(tetra{\-}hydro-2{\it H}-pyran-2-yl)oxythia{\-}zole-2(3{\it H})-thione ({\bf MTTOTHP}) was investigated using X-ray diffraction and computational chemistry methods for determining properties of the nitro{\-}gen{---}oxygen bond, which is the least stable entity upon photochemical excitation. (uni-bayreuth.de)
  • Product Name: Kojic acid Synonyms: 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-;4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-;5-hydroxy-2-(hydroxymethyl)-4h-pyran-4- on;kojic;Pyran-4-one, 5-hydroxy-2-(hydroxymethyl);2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE;2. (vvchem.com)
  • Although the pyrans themselves have little significance in chemistry, many of their derivatives are important biological molecules, such as the pyranoflavonoids. (wikipedia.org)
  • Spirooxindole derivatives and polycyclic ring systems, such as spirodecanes, all-carbon tricycles, and pyran polycycles, are found in many bioactive natural products. (thieme-connect.com)
  • PYRAN® fire-resistant glazing is superior to conventional safety glass for a number of reasons. (schott.com)
  • All types of SCHOTT fire-resistant glass is CE-certified and classified in accordance with EN 13501-2. (schott.com)
  • Curved PYRAN® fire-resistant glass fits seamlessly with the curved railing of the office entrance, allowing light to flow from the glass roof of the fifth floor. (schott.com)
  • To ensure the gangway is well lit during the day, the building's architects, VIB Architecture, chose PYRAN® S fire-resistant glass with concealed fixtures for the smoke screen. (schott.com)
  • PYRAN® S is a pre-stressed monolithic borosilicate safety glass, while ISO PYRAN® S is a double-glazed unit offering extra insulation and protection. (schott.com)
  • PYRAN® S smoke screens made with borosilicate glass offer a very high transparency of 92 %, while a thickness of just 5 mm (11.5 kg/m²) makes them lighter than other screens. (schott.com)
  • In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one oxygen atom and containing two double bonds. (wikipedia.org)
  • PYRAN® glazing retains outstanding transparency in extreme temperatures. (schott.com)
  • Due to the excellent transparency of PYRAN® S smoke screens, the smoke curtain is almost invisible, but in the event of a fire you can rely on its protective mechanism. (schott.com)
  • Integrating discreetly into your design, the powerful heat resistance of PYRAN® provides vital protection for occupants of residential buildings and workplaces. (schott.com)
  • The term pyran is also often applied to the saturated ring analog, which is more properly referred to as tetrahydropyran (oxane). (wikipedia.org)
  • The high viscosity of PYRAN® results in low flow behavior. (schott.com)
  • PYRAN® has been a globally trusted safety glazing product for decades, and it's likely you will have already benefitted from its protection in many areas of everyday life. (schott.com)
  • For eight of these alkaloids, the group describes the first total synthesis: murrayamine A (mukoenine C), mahanine, murrayamine B, D, and H, and clauszoline G, B, and H. Key steps in the synthesis feature a palladium-catalyzed construction of the carbazole nucleus and a boronic acid catalyzed annulation of the pyran ring. (chemistryviews.org)