Pyelonephritis: Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.Pyelonephritis, Xanthogranulomatous: A chronic inflammatory condition of the KIDNEY resulting in diffuse renal destruction, a grossly enlarged and nonfunctioning kidney associated with NEPHROLITHIASIS and KIDNEY STONES.Escherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.Technetium Tc 99m Dimercaptosuccinic Acid: A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Vesico-Ureteral Reflux: Retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.Bacteriuria: The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.Emphysema: A pathological accumulation of air in tissues or organs.Kidney Papillary Necrosis: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.Proteus Infections: Infections with bacteria of the genus PROTEUS.Pyelitis: Inflammation of the KIDNEY PELVIS and KIDNEY CALICES where urine is collected before discharge, but does not involve the renal parenchyma (the NEPHRONS) where urine is processed.Acute Disease: Disease having a short and relatively severe course.Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Kidney Pelvis: The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.Adhesins, Escherichia coli: Thin, filamentous protein structures, including proteinaceous capsular antigens (fimbrial antigens), that mediate adhesion of E. coli to surfaces and play a role in pathogenesis. They have a high affinity for various epithelial cells.Fimbriae, Bacterial: Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).Ceftriaxone: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Proteus mirabilis: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.Urography: Radiography of any part of the urinary tract.Anti-Infective Agents, Urinary: Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.Pregnancy Complications, Infectious: The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.Pyelocystitis: Inflammation of the KIDNEY PELVIS and the URINARY BLADDER.Urinary Tract: The duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.Urolithiasis: Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.

*  Imaging in Emphysematous Pyelonephritis: Overview, Radiography, Computed Tomography
Imaging is essential to managing emphysematous pyelonephritis -a life-threatening, fulminant, necrotizing upper urinary tract ... Xanthogranulomatous pyelonephritis presenting as emphysematous pyelonephritis: a rare association. J Postgrad Med. 1999 Oct-Dec ... Imaging in Emphysematous Pyelonephritis. Updated: Jun 10, 2016 * Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: ... Emphysematous pyelonephritis- conversion of type i to type II appearance on serial CT studies. Clin Imaging. 1999 Nov-Dec. 23(6 ...
  https://emedicine.medscape.com/article/378197-overview
*  Pyelonephritis | Diagnosis and conservative treatment. Nephrology: Treatment in Germany, Marburg hospitals on BookingHealth.com
Pyelonephritis , Diagnosis and conservative treatment. Nephrology: Treatment in Marburg, Germany ✈. Prices on BookingHealth.com ... Diagnosis and conservative treatment of pyelonephritis #41003. The Department of Nephrology treats patients with internal ...
  https://bookinghealth.com/programs/treatment/nefrology/pyelonephritis-diagnosis-and-conservative-treatment/germany/marburg
*  Acute Pyelonephritis Illustration by Todd Buck | Medical Illustration & Animation
Acute pyelonephritis is inflammation and infection in kidneys. Shown are glowing kidneys, bacteria, urine sample, thermometer, ... Acute pyelonephritis is inflammation and infection in kidneys. Shown are glowing kidneys, bacteria, urine sample, thermometer, ...
  http://www.medillsb.com/illustration_image_details.aspx?AID=261&IID=82272
*  Chapter 288. Urinary Tract Infections, Pyelonephritis, and Prostatitis | Harrison's Principles of Internal Medicine, 18e |...
Pyelonephritis. ++. Mild pyelonephritis can present as low-grade fever with or without lower-back or costovertebral-angle pain ... Pyelonephritis. ++. Since patients with pyelonephritis have tissue-invasive disease, the treatment regimen chosen should have a ... pyelonephritis. Factors independently associated with pyelonephritis in young healthy women include frequent sexual intercourse ... risk factors for cystitis and pyelonephritis are not surprising given that pyelonephritis typically arises through the ascent ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727077
*  Fluoride Dangers: December 2005
It seems probable that in this patient and in those with chronic pyelonephritis the high concentrations of fluorine found in ... E. P., 39 years old, had advanced pyelitis (another name for pyelonephritis, Janet Lail's disease) of the left kidney, bone ... But she probably doesn't know that the literature is littered with warnings that people with pyelonephritis should avoid ... In persons with advanced bilateral pyelonephritis, the skeletal fluoride content can be 4-fold that of similarly-exposed ...
  http://fluoridedangers.blogspot.ca/2005/12/
*  Pyelonephritis | Reality And Myths
Pyelonephritis is an inflammatory disease. It can develop as a result of ... Pyelonephritis is a disease of the kidney parenchyma and the bowl-and-pelvis system. ... Pyelonephritis is a disease of the kidney parenchyma and the bowl-and-pelvis system. Pyelonephritis is an inflammatory disease ... Pyelonephritis is a common kidney disease. In fact, among children, pyelonephritis belongs to the second place after diseases ...
  http://realityandmyths.com/pyelonephritis/
*  Emphysematous Pyelonephritis | Renal Treatment Centers
Renal Infection is an infection of kidney which is caused by a bacteria known as e-coli, this bacteria enters the body with the blood, once infected by this bacteria the conditions of high fever along with the back pain occurs, the bladder too gets infected by this bacteria. This infection is really fatal and can Read more ...
  http://renaltreatment.com/tag/emphysematous-pyelonephritis/
*  Kidney Infection (Pyelonephritis): Signs, Symptoms & Treatment
... pyelonephritis) causes for example, a UTI, kidney stones, pregnancy and more. Common symptoms include back pain, fever, chills ... Pyelonephritis, Acute ». Acute pyelonephritis is a potentially organ- and/or life-threatening infection that characteristically ... Infection of the kidney(s) is also known as pyelonephritis.. *Urinary tract infections are very common and may affect 40% of ... The eMedicineHealth doctors ask about Kidney Infection (Pyelonephritis):. Kidney Infection - Symptoms. What were the symptoms ...
  https://www.emedicinehealth.com/kidney_infection/article_em.htm
*  Kidney Infection
... how is pyelonephritis diagnosed, what are treatment options for pyelonephritis, and how to prevent pyelonephritis. ... Pyelonephritis is also known as a kidney infection or renal infection. The program includes the following sections: what is the ... anatomy of the urinary system, what are symptoms of pyelonephritis, what are the causes of pyelonephritis, ... how is pyelonephritis diagnosed, what are treatment options for pyelonephritis, and how to prevent pyelonephritis.. 1.. ...
  http://www.patient-education.com/englisha/topic/kidney-infection
*  Reoccuring Pyelonephritis - I cannot get a diagnosis. - Condition | Our Health
I am 17 years old and have been suffering from recurrent pyelonephritis. It all started in May 2007, I experienced extremely ...
  http://www.ourhealth.com/conditions/i-cannot-get-a-diagnosis/reoccuring-pyelonephritis
*  What is Pyelonephritis?
Types of pyelonephritis. Primary acute pyelonephritis represents the inflammation of the renal parenchyma and affects one or ... Presentation of secondary acute pyelonephritis (sometimes referred to as complicated acute pyelonephritis) resembles primary ... Pyelonephritis can be defined as an infection of the renal pelvis and kidney that is a consequence of the ascent of pathogenic ... All types of pyelonephritis are appreciably more common in females than in males, although this difference wanes with ...
  https://www.news-medical.net/health/What-is-Pyelonephritis.aspx
*  Emphysematous pyelonephritis
... DISCUSSION. Emphysematous pyelonephritis (EPN) is a radiologically diagnosed life-threatening, ... Emphysematous pyelonephritis is a potentially serious fulminant bacterial infection of the kidneys characterized by gas in the ... She was treated conservatively with antibiotics for the pyelonephritis and with a ureteral stent to relieve the hydronephrosis ... Michaeli J, Mogle P, Perlberg S, Heiman S, Caine M. Emphysematous pyelonephritis. J Urol. 1984; 131:203-208. ...
  http://appliedradiology.com/articles/emphysematous-pyelonephritis
*  Synonyms for chronic pyelonephritis | Synonym.com
1. chronic pyelonephritis (n.). pyelonephritis that develops slowly and can lead to renal failure if untreated; often ...
  http://www.synonym.com/synonyms/chronic%20pyelonephritis
*  Pyelonephritis/ Perinephric abscess - Renal and Urology News
Acute Pyelonephritis/Perinephric Abscess. I. What every physician needs to know.. Acute pyelonephritis is an infection of the ... Acute Pyelonephritis. Since acute pyelonephritis is an infection of the upper structures of the urinary tract the symptoms are ... Acute complicated pyelonephritis can occur in both women and men. Risk factors for acute complicated pyelonephritis include:. 1 ... Acute Graft Pyelonephritis Does Not Adversely Affect Long-Term Transplant Outcomes. *CRP Levels May Predict Pyelonephritis ...
  http://www.renalandurologynews.com/hospital-medicine/pyelonephritis-perinephric-abscess/article/602203/
*  Acute Pyelonephritis in Adults.
... N Engl J Med. 2018 Jan 04;378(1):48-59. Authors: Johnson JR, Russo TA. PMID: 29298155 [PubMed - in process] ...
  http://beckerinfo.net/JClub/2018/01/04/acute-pyelonephritis-in-adults/
*  Pyelonephritis (Kidney Infection) - Stock Image C022/1668 - Science Photo Library
... pyelonephritis, upper left). Pyelonephritis may be either acute or chronic. The acute form is usually caused when bacteria ... Caption: Illustration of an infection of a kidney (pyelonephritis, upper left). Pyelonephritis may be either acute or chronic. ... pyelonephritis, renal, sectioned, ureter, ureters, urinary, vertical, white background ...
  http://www.sciencephoto.com/media/617217/view
*  Focal pyelonephritis | Radiology Case | Radiopaedia.org
Features of focal pyelonephritis. There is no collection, so this is not an abscess. While other differentials may be ... With the features of sepsis and infection, features here are most in keeping with focal pyelonephritis. ... Features of focal pyelonephritis. There is no collection, so this is not an abscess. ...
  https://radiopaedia.org/cases/focal-pyelonephritis
*  Obstructive pyelonephritis | Radiology Case | Radiopaedia.org
This case illustrates a complicated obstructive pyelonephritis, which usually requires prompt treatment aiming to save the ... A: Obstructive pyelonephritis should be considered as a possibility for the sepsis and acute renal impairment. ... This case illustrates a complicated obstructive pyelonephritis, which usually requires prompt treatment aiming to save the ...
  https://radiopaedia.org/cases/obstructive-pyelonephritis
*  Chronic Pyelonephritis at Autopsy | Annals of Internal Medicine | American College of Physicians
About 6 years ago, an analysis of the frequency with which chronic pyelonephritis(About 6 years ago, an analysis of the ... Once again, the frequency with which the diagnosis of chronic pyelonephritis was made in males exceeded that anticipated from) ... Chronic Pyelonephritis at Autopsy. Ann Intern Med. 1967;66:697-710. doi: 10.7326/0003-4819-66-4-697 ... The rates of urinary infection were determined in the clinic and compared with the diagnosis of chronic pyelonephritis at ...
  http://annals.org/aim/article-abstract/681298/chronic-pyelonephritis-autopsy
*  A genetic basis of susceptibility to acute pyelonephritis.
... Lundstedt, Ann-Charlotte LU ; McCarthy, Shane; Gustafsson, Mattias ... The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with ... The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with ... The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with ...
  https://lup.lub.lu.se/search/publication/607964
*  Will chronic pyelonephritis affect my other kidney as well?
Last year I was affected by ,b,chronic pyelonephritis,/b,. After total abdomen scan and IVP tests, it was confirmed that I have ... I am afraid that chronic pyelonephritis might affect to the left kidney also. Is there a chance of the other kidney getting ... I was advised Alsartan 25 mg for hypertension regularly since the time I was diagnosed with chronic pyelonephritis. Now, I have ... chronic pyelonephritis and right atrophic kidney. I took antibiotics for one week (each day 1000 mg). ...
  https://doctor.ndtv.com/faq/will-chronic-pyelonephritis-affect-my-other-kidney-as-well-10175
*  Pyelonephritis Doctor Specialties : Learning Center on Healthline.com
The American Board of Medical Specialties recognizes Family Medicine as a distinct discipline requiring an additional three years of training for doctors who wish to become Board Certified in this field. Family Medicine doctors are usually primary care providers (PCPs) [formerly general practitioners, or GPs] for the entire family ...
  https://www.aarpmedicareplans.com/channel/pyelonephritis_doctorspecialties
*  Pyelonephritis Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Pyelonephritis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, ... Contents for Pyelonephritis: *Pyelonephritis *What is Pyelonephritis? *Prognosis of Pyelonephritis *Causes of Pyelonephritis * ... Pyelonephritis: Deaths. Read more about Deaths and Pyelonephritis. Diagnostic Tests for Pyelonephritis. Test for Pyelonephritis ... Symptoms of Pyelonephritis *Diagnostic Tests for Pyelonephritis *Home Testing and Pyelonephritis *Diagnosis of Pyelonephritis * ...
  http://www.rightdiagnosis.com/p/pyelonephritis/intro.htm

Glitter cell: Glitter cells are neutrophils that are found in the urine, most commonly associated with urinary tract infections and pyelonephritis. They derive their name from their appearance when viewed on a wet mount preparation under a microscope; the granules within their cytoplasm can be seen moving, giving them a "glittering appearance.Xanthogranulomatous osteomyelitis: Xanthogranulomatous osteomyelitis (XO) is a peculiar aspect of osteomyelitis characterized by prevalent histiocytic infiltrate and foamy macrophage clustering.Rosai J(2004).DMSA scan: A DMSA scan is a radionuclide scan that uses dimercaptosuccinic acid (as a radioactive tracer) in assessing renal morphology, structure (static scan), and function. It is sometimes used as a test for the diagnosis of acute pyelonephritis.Cystitis glandularis: Cystitis glandularis is a term describing a metaplastic transformation of mucosal cells lining the urinary bladder. The main importance is in histopathology, distinguishing the metaplastic change from urothelial cell carcinoma.Pathogenic Escherichia coli: Escherichia coli ( Anglicized to ; commonly abbreviated E. coli) is a gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms).Reflux nephropathyAspirin/paracetamol/caffeineKidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Dimercaptosuccinic acidSaf pilin N-terminal extension: In molecular biology, the protein domain, Saf pilin N-terminal extension refers to a domain only found in bacteria, more specifically, in gram-negative bacteria. Pili need to be formed by bacteria, as they are a method of adhering to the host organism which helps them infect the host cell.Pilin: Pilin refers to a class of fibrous proteins that are found in pilus structures in bacteria. Bacterial pili are used in the exchange of genetic material during bacterial conjugation, while a shorter type of appendages also made up of pilin, called fimbriae, are used as a cell adhesion mechanism.CeftriaxoneList of strains of Escherichia coli: Escherichia coli is a well studied bacterium that was first identified by Theodor Escherich, after whom it was later named.Mirabilis: Mirabilis is a Latin adjective meaning "amazing, wondrous, remarkable", and is used to refer to:Gas pyelogram: A Gas pyelogram is a pyelogram in which the kidneys, renal pelvis and ureters are filled with gas, and have a radiolucent appearance. This gas is produced by some gas producing micro organisms which infect most upper parts of urinary system.UrolithiasisBacitracin

(1/594) Urinary tract infections in adults.

Urinary tract infections remain a significant cause of morbidity in all age groups. Recent studies have helped to better define the population groups at risk for these infections, as well as the most cost-effective management strategies. Initially, a urinary tract infection should be categorized as complicated or uncomplicated. Further categorization of the infection by clinical syndrome and by host (i.e., acute cystitis in young women, acute pyelonephritis, catheter-related infection, infection in men, asymptomatic bacteriuria in the elderly) helps the physician determine the appropriate diagnostic and management strategies. Uncomplicated urinary tract infections are caused by a predictable group of susceptible organisms. These infections can be empirically treated without the need for urine cultures. The most effective therapy for an uncomplicated infection is a three-day course of trimethoprim-sulfamethoxazole. Complicated infections are diagnosed by quantitative urine cultures and require a more prolonged course of therapy. Asymptomatic bacteriuria rarely requires treatment and is not associated with increased morbidity in elderly patients.  (+info)

(2/594) Local production of inflammatory mediators in an experimental model of acute obstructive pyelonephritis.

To investigate bacterial growth and inflammatory mediator release in the early stage of the immune response, a unilateral acute ascending pyelonephritis was induced in rats by intrabladder inoculation of Escherichia coli. The infected left kidney showed a significant bacterial proliferation, local production of interleukin (IL)-6 and IL-8 as detected by immunocytochemistry, and extensive destruction of renal parenchyma associated with impressive leukocyte recruitment. Inducible and constitutive nitric oxide synthases (NOS) were locally expressed, and a time-dependent increase in urinary secretion of nitric oxide (NO) was seen that could be blocked by NG-monomethyl-L-arginine. However, there was a discrepancy between the NO profile in the kidney and urine. The results demonstrate that in the early stage of acute pyelonephritis kidney tubules participate actively in the local host response by producing important inflammatory mediators and that urinary NO levels are not suitable for predicting renal NOS activity.  (+info)

(3/594) Quantitative 99mTc-DMSA uptake in experimental pyelonephritis.

Quantitative 99mTc-dimercaptosuccinic acid (DMSA) renal uptake was studied in unilateral reflux-related pyelonephritis in pigs. The changes to absolute % dose uptake and differential uptake occurring with induction and after treatment of pyelonephritis were correlated with the DMSA images and renal pathology. METHODS: Quantitative uptake in 53 young pigs was obtained from planar images acquired 6 h after injecting the dose. Baseline studies were made (Q1), and studies were made again after urinary infection was established (Q2), when 8 pigs had normal (no defect) renal images (group A), 23 had photon-deficient (reversible) focal defects (group B) and 22 had photon absent (irreversible) focal defects (group C). Q3 studies were made in 21 animals from groups B and C after 3-wk antimicrobial treatment. RESULTS: At Q2 the affected kidney differential uptake was unchanged for group A and reduced for groups B and C (respective mean changes -1.7%, P < 0.01; and -5.5%, P < 0.01). The absolute % dose uptake was unchanged in pyelonephritic kidneys, but increased in the contralateral nondiseased kidneys in groups B and C (respective mean increases +1.4%, P < 0.05; and +5.4%, P < 0.01), while remaining unchanged for group A. In group C, global renal accumulation was actually increased above the Q1 values. After treatment (Q3) the reduced pyelonephritic kidney differential uptake persisted in groups B and C. In group C, however, the increased absolute % dose uptake by the contralateral kidney was less marked and not significantly different from Q1 values in this small group. CONCLUSION: Induction of unilateral pyelonephritis produced a small reduction in diseased kidney differential uptake that was greatest in the group with irreversible imaging defects. The method did not discriminate individuals with reversible and irreversible imaging defects. The decrease in pyelonephritic kidney differential uptake resulted from increased DMSA accumulation (absolute % dose uptake) by the nondiseased contralateral kidney, while that in pyelonephritic kidneys remained unchanged. After treatment, the reduced pyelonephritic kidney differential uptake persisted, but the elevated global DMSA accumulation seen for group C (with irreversible imaging defects) was not sustained and was variable.  (+info)

(4/594) Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration.

Temporal variations in the renal toxicity of aminoglycosides have been reported for experimental animals as well as for humans. In fact, maximal renal toxicity of aminoglycosides was observed when the drug was given during the rest period, while a lower toxicity was observed when the drug was injected during the activity period. The aim of the present study was to evaluate temporal variations in the effectiveness and renal toxicity of gentamicin in an experimental model of pyelonephritis in rats. The experiments were carried out with female Sprague-Dawley rats (185 to 250 g). They had free access to food and water throughout the study and were maintained on a 14-h light-10-h dark cycle. Animals were divided into four groups corresponding to the respective time of induction of pyelonephritis and treatment: 0700, 1300, 1900, and 0100 h. Pyelonephritis was induced by a direct inoculation of Escherichia coli (10(7) to 10(8) CFU) in the left kidney. Animals were treated for 3 and 7 days with a single daily dose of gentamicin (20 and 40 mg/kg of body weight, respectively) or saline (NaCl, 0.9%) at either 0700, 1300, 1900, or 0100 h. Animals treated at 0100 h for 3 days with gentamicin (20 mg/kg) showed a significantly lower number of bacteria in their kidneys than did all other groups (P < 0.01). After 7 days of treatment, the efficacy, evaluated by the log CFU per gram of tissue and by the percentage of sterilized kidneys, was also higher when gentamicin was administered at 0100 h. The beta-galactosidase and the N-acetyl-beta-D-glucosaminidase activities were significantly higher in urine of rats given gentamicin at 1300 h than in urine of rats treated at another time of day (P < 0.05). Gentamicin injected at 1300 h induced a significantly greater increase of [3H]thymidine incorporation into DNA of renal cortex (P < 0.01), a significantly greater inhibition of sphingomyelinase activity (P < 0.05), and significantly more histopathological lesions than the same dose injected at another time of the day. Creatinine and blood urea nitrogen levels in serum were significantly higher (P < 0.05) and the creatinine clearance was significantly lower (P < 0.05) when gentamicin was injected at 1300 h than when it was injected at another time of day. Our data suggest temporal variations in both the toxicity and the effectiveness of gentamicin, the drug being more effective and less toxic when injected during the activity period of the animals.  (+info)

(5/594) Inverse relationship between severity of experimental pyelonephritis and nitric oxide production in C3H/HeJ mice.

The contribution of nitric oxide to host resistance to experimental pyelonephritis is not well understood. We examined whether the inhibition of nitric oxide synthesis alters the sensitivity of lipopolysaccharide (LPS) responder (C3H/HeN) and nonresponder (C3H/HeJ) mice to experimental Escherichia coli pyelonephritis. C3H/HeJ and C3H/HeN mice were implanted subcutaneously with minipumps containing an inhibitor of nitric oxide, NG-nitro-L-arginine methyl ester (L-NAME), or a corresponding vehicle. Ascending urinary tract infection by bladder catheterization with two strains of E. coli, an O75 strain bearing Dr fimbriae and an O75 strain bearing P fimbriae, was developed in tested animals. Twenty-four hours following bladder infection, the kidneys of C3H/HeN and C3H/HeJ mice were colonized at a similar rate. However, 5 weeks postinoculation, C3H/HeN mice cleared infection while C3H/HeJ mice showed persistent colonization. Twenty-four hours following infection, C3H/HeN mice treated with L-NAME showed no significant increase of renal tissue infection compared to the saline-treated control group. However, L-NAME-treated C3H/HeJ mice showed an approximately 100-fold increase in E. coli infection rate compared to the saline-treated controls in the Dr+ group but showed no change compared to those in the P+ group. Dissemination of Dr+ E. coli but not P+ E. coli to the liver and uterus was significantly enhanced with L-NAME treatment in C3H/HeJ mice only. Nitric oxide had no direct killing effect on E. coli in vitro. Nitrite production by various organs was found to be significantly lower in C3H/HeJ mice than in C3H/HeN mice. Alteration of nitric oxide and LPS responsiveness was significantly associated with the increased sensitivity of C3H/HeJ mice to experimental Dr+ but not to P+ E. coli pyelonephritis. These findings are consistent with the hypothesis that nitric oxide synthase activity in concert with LPS responsiveness may participate in the antibacterial defense mechanisms of the C3H mouse urinary tract. This phenomenon is strain dependent and possibly related to the invasive properties of E. coli.  (+info)

(6/594) Increased urine interleukin-6 concentrations correlate with pyelonephritic changes on 99mTc-dimercaptosuccinic acid scans in neonates with urinary tract infections.

Interleukin (IL)-6 and -8 are important inflammatory cytokines in bacterial infections. Their serum and urine concentrations were measured in 27 neonates with urinary tract infection (UTI) at onset and the second week of therapy, as well as in 23 control neonates. Escherichia coli was isolated in 89% of cases. 99mTc-dimercaptosuccinic acid (99mTc-DMSA) scans were performed between the 10th and 90th days after UTI and showed pyelonephritic changes in 15 neonates (56%). Increased IL-6 and IL-8 concentrations were found in urine but not in serum within the first 24 h after presumptive diagnosis of UTI (P=.036 and.010, respectively), suggesting that the neonatal urinary tract can respond to uropathogens by producing inflammatory cytokines. Urine concentrations of IL-6 correlated with findings of renal changes in 99mTc-DMSA scans (P=.012) and thus may serve as a marker of renal parenchymal outcome. All neonates exhibited undetectable urine cytokine levels during the second week of therapy.  (+info)

(7/594) Neutrophil recruitment and resistance to urinary tract infection.

This study examined the role of neutrophil leukocytes for the antibacterial defense at mucosal infection sites. Urinary tract infection (UTI) was established by injection into the bladder lumen of Escherichia coli 1177, a fully virulent clinical isolate. Infection of C3H/HeN (lpsn, lpsn) mice recruited neutrophils into the urinary tract, and bacteria were cleared from kidneys and bladders. The neutrophil response was absent in C3H/HeJ (lpsd, lpsd) mice, and bacteria persisted in the tissues. Peripheral neutrophil depletion of C3H/HeN mice was subsequently achieved by pretreatment with the granulocyte-specific antibody RB6-8C5. The E. coli-induced neutrophil recruitment was inhibited, as shown by immunohistochemistry and tissue myeloperoxidase quantitation. As a consequence, bacterial clearance from kidneys and bladders was drastically impaired. Antibody treatment of C3H/HeJ mice had only a marginal effect. The results show that neutrophils are essential for bacterial clearance from the urinary tract and that the neutrophil recruitment deficiency in C3H/HeJ mice explains their susceptibility to gram-negative UTI.  (+info)

(8/594) Virulence characteristics of Escherichia coli in acute bacterial prostatitis.

To assess the urovirulence characteristics of Escherichia coli strains causing acute prostatitis, urinary isolates from men with acute prostatitis (n=107) and from women with acute uncomplicated pyelonephritis (n=76) were examined for the prevalence of sfa, foc, and 3 papG allele genotypes and phenotypes and for the production of alpha-hemolysin and cytotoxic necrotizing factor 1. The papG allele III and foc gene were found more frequently and the papG allele II less frequently among prostatitis than from pyelonephritis isolates. A higher proportion of hly+ cnf1+ genotype in prostatitis strains (64% vs. 36%) was particularly striking. Both prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of acute prostatitis.  (+info)



  • renal
  • Chronic pyelonephritis is a complex renal disorder characterised by chronic tubulointerstitial inflammation and deep segmental cortical renal scarring and clubbing of the pelvic calyces as the papillae retract into the scars. (bmj.com)
  • kidney
  • Pyelonephritis - from the Greek 'pyelo' (pelvis), 'nephros' (kidney), and 'itis' (inflammation) - refers to an inflammation of the kidney that can be acute, recurrent, or chronic. (bmj.com)