An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
A group of compounds that contain the general formula R-OCH3.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Drug-induced depression of consciousness during which patients cannot be easily aroused but respond purposely following repeated painful stimulation. The ability to independently maintain ventilatory function may be impaired. (From: American Society of Anesthesiologists Practice Guidelines)
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Devices used to assess the level of consciousness especially during anesthesia. They measure brain activity level based on the EEG.
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Sense of awareness of self and of the environment.
A family of hexahydropyridines.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
"Medicine in Art" refers to the depiction or use of medical themes, practices, or symbolism in various art forms, such as paintings, sculptures, literature, and performing arts, often serving educational, historical, or aesthetic purposes.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics. (1/1774)

AIMS: Propofol is a widely used i.v. anaesthetic agent. However, its binding properties to blood components have not been fully studied. METHODS: We studied the binding of propofol to erythrocytes, to human serum and to isolated serum proteins. Because propofol bound to ultrafiltration and equilibrium dialysis membranes, we used a co-binding technique with dextran coated charcoal and with erythrocytes. RESULTS: Propofol free fraction in blood was 1.2-1.7% at total concentrations ranging from 2.80 to 179 microM (0.5 to 32 microg ml(-1)). Fifty percent was bound to erythrocytes and 48% to serum proteins, almost exclusively to human serum albumin. In the clinical range of concentrations (0.5-16 microg ml(-1)) 40% of the molecules bound to erythrocytes are on the red blood cells membranes. No binding to lipoproteins occurred and binding to alpha1-acid glycoprotein was less than 1.5% CONCLUSIONS: We conclude that hypoalbuminaemia may increase propofol free fraction particularly during prolonged administration. Since propofol is non-restrictively cleared, no change in clearance is expected to occur, and the increase in free fraction will not be compensated by a parallel increase in clearance. It is also noted that many in vitro studies used concentrations 50 to 500 times the concentration expected to be encountered in the immediate cellular environment.  (+info)

Mechanisms of bronchoprotection by anesthetic induction agents: propofol versus ketamine. (2/1774)

BACKGROUND: Propofol and ketamine have been purported to decrease bronchoconstriction during induction of anesthesia and intubation. Whether they act on airway smooth muscle or through neural reflexes has not been determined. We compared propofol and ketamine to attenuate the direct activation of airway smooth muscle by methacholine and limit neurally mediated bronchoconstriction (vagal nerve stimulation). METHODS: After approval from the institutional review board, eight sheep were anesthetized with pentobarbital, paralyzed, and ventilated. After left thoracotomy, the bronchial artery was cannulated and perfused. In random order, 5 mg/ml concentrations of propofol, ketamine, and thiopental were infused into the bronchial artery at rates of 0.06, 0.20, and 0.60 ml/min. After 10 min, airway resistance was measured before and after vagal nerve stimulation and methacholine given via the bronchial artery. Data were expressed as a percent of baseline response before infusion of drug and analyzed by analysis of variance with significance set at P< or =0.05. RESULTS: Systemic blood pressure was not affected by any of the drugs (P>0.46). Baseline airway resistance was not different among the three agents (P = 0.56) or by dose (P = 0.96). Infusion of propofol and ketamine into the bronchial artery caused a dose-dependent attenuation of the vagal nerve stimulation-induced bronchoconstriction to 26+/-11% and 8+/-2% of maximum, respectively (P<0.0001). In addition, propofol caused a significant decrease in the methacholine-induced bronchoconstriction to 43+/-27% of maximum at the highest concentration (P = 0.05) CONCLUSIONS: The local bronchoprotective effects of ketamine and propofol on airways is through neurally mediated mechanisms. Although the direct effects on airway smooth muscle occur at high concentrations, these are unlikely to be of primary clinical relevance.  (+info)

Propofol concentrations in follicular fluid during general anaesthesia for transvaginal oocyte retrieval. (3/1774)

Propofol (Diprivan) is an i.v. anaesthetic used for general anaesthesia. The purpose of this study was to measure the propofol concentration in arterial blood and follicular fluid in patients during transvaginal oocyte retrieval. After approval by the University Ethics Committee, 30 women participated in this prospective study. Following induction of anaesthesia with 0.5 mg alfentanil and 2 mg.kg-1 propofol i.v., a continuous infusion of propofol at 10 mg.kg-1.h-1 was used for maintenance of anaesthesia. Follicular fluid and arterial blood samples were aspirated simultaneously at fixed intervals during the surgical procedure and propofol assayed by high pressure liquid chromatography (HPLC). The mean follicular fluid concentration of propofol increased linearly with time from 0.10 +/- 0.02 microgram.ml-1 to 0.57 +/- 0.06 microgram.ml-1 and was strongly related to the cumulative dose of propofol administered. The absorption of propofol was time-dependent. There was no correlation between the concentration of propofol in the follicular fluid and the arterial blood concentration of the drug. In conclusion, a propofol-based anaesthetic technique resulted in significant concentrations of this agent in follicular fluid, related to the dose administered and to the duration of propofol administration.  (+info)

Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones. (4/1774)

The effect of a novel potentiator of glycine responses, ICS 205,930, was studied by whole-cell recordings from spinal neurones, and compared with that of other known potentiators, in an attempt to differentiate their sites of action. The ability of ICS 205,930 (0.2 microM) to potentiate glycine responses persisted in the presence of concentrations of Zn2+ (5-10 microM) that were saturating for the potentiating effect of this ion. Preincubation with 10 microM Zn2+ before application of glycine plus Zn2+ had an inhibitory effect, which did not result from Zn2+ entry into the neurone, since it persisted with either 10 mM internal EGTA or 10 microM internal Zn2+. To test whether the potentiating effects of ICS 205,930 and Zn2+ interact, both compounds were applied without preincubation. The potentiating effect of ICS 205,930 was similar for responses to glycine and for responses to glycine plus Zn2+, provided the concentrations of agonist were adjusted so as to induce control responses of identical amplitudes. ICS 205,930 remained able to potentiate glycine responses in the presence of ethanol (200 mM). ICS 205,930 also retained its potentiating effect in the presence of the anaesthetic propofol (30 90 microM), which strongly potentiated glycine responses but, in contrast with ICS 205,930, also markedly increased the resting conductance. The anticonvulsant chlormethiazole (50-100 microM) neither potentiated glycine responses nor prevented the effect of ICS 205,930, even though it increased the resting conductance and potentiated GABA(A) responses. The mechanism of action of ICS 205,930 appears to be different from those by which Zn2+, propofol or ethanol potentiate glycine responses.  (+info)

Effects of inhaled oxygen concentration on fat metabolism during propofol infusion in rabbits. (5/1774)

We have investigated the effect of inhaled oxygen tension on lipid metabolism during propofol infusion. Propofol is supplied as a lipid emulsion containing 10% soybean oil, which is rich in triglycerides (TG). Infused TG are metabolized via three pathways in the liver cell; Krebs cycle, ketogenesis and release as very low density lipoproteins (VLDL) into the blood. For this reason, we measured TG and the products of the three pathways; carbon dioxide, ketone bodies and VLDL. Thirty-two rabbits were anaesthetized under four different conditions: propofol under hyperoxia, normoxia, hypoxia and isoflurane anaesthesia under hyperoxia. Our results indicated that hyperoxia produced more ketone bodies, normoxia more PaCO2 and hypoxia more free fatty acids (FFA) and TG compared with the other propofol infusion groups. We conclude that hyperoxia during propofol infusion facilitated fat metabolism through ketogenesis, while normoxia did so via the Krebs cycle. Also, hypoxia suppressed utilization of TG and VLDL production in the liver.  (+info)

Thiopental and propofol impair relaxation produced by ATP-sensitive potassium channel openers in the rat aorta. (6/1774)

ATP-sensitive potassium channel openers are used as vasodilators in the treatment of cardiovascular disorders. The effects of i.v. anaesthetics on arterial relaxation induced by ATP-sensitive potassium channel openers have not been studied. Therefore, in this study, we have examined if thiopental (thiopentone) and propofol affect the vascular response to the ATP-sensitive potassium channel openers, cromakalim and pinacidil, in the isolated rat aorta. Rings of rat thoracic aortas without endothelium were suspended for isometric force recording. Concentration-response curves were obtained in a cumulative manner. During submaximal contractions with phenylephrine 0.3 mumol litre-1, relaxation after cromakalim 0.1-30 mumol litre-1, pinacidil 0.1-30 mumol litre-1 and papaverine 0.1-300 mumol litre-1 was demonstrated. Thiopental 30-300 mumol litre-1, propofol 10-100 mumol litre-1, 10% Intralipid 45 microliters or glibenclamide 5 mumol litre-1 were applied 15 min before addition of phenylephrine. During contractions with phenylephrine, cromakalim and pinacidil induced concentration-dependent relaxation. A selective ATP-sensitive potassium channel antagonist, glibenclamide 5 mumol litre-1, abolished this relaxation, whereas it did not affect relaxation produced by papaverine. Thiopental concentrations > 30 mumol litre-1 significantly impaired relaxation produced by cromakalim or pinacidil. Propofol concentrations > 10 mumol litre-1 also significantly reduced relaxation produced by cromakalim or pinacidil, whereas Intralipid was ineffective. Thiopental 300 mumol litre-1 and propofol 100 mumol litre-1 did not alter relaxation produced by papaverine. These results suggest that the i.v. anaesthetics, thiopental and propofol, impaired vasodilatation mediated by ATP-sensitive potassium channels in vascular smooth muscle cells.  (+info)

Effect of remifentanil on the auditory evoked response and haemodynamic changes after intubation and surgical incision. (7/1774)

We have observed the effect of intubation and incision, as measured by the auditory evoked response (AER) and haemodynamic variables, in 12 patients undergoing hernia repair or varicose vein surgery who received remifentanil as part of either an inhaled anaesthetic technique using isoflurane or as part of a total i.v. technique using propofol. Anaesthesia was induced with remifentanil 1 microgram kg-1 and propofol, neuromuscular block was achieved with atracurium 0.6 mg kg-1 before intubation, and anaesthesia was maintained with a continuous infusion of remifentanil in combination with either a continuous infusion of propofol or inhaled isoflurane. The AER and haemodynamic variables were measured before and after intubation and incision. The effects of intubation and incision on the AER and haemodynamic variables were not significantly different between the remifentanil-propofol and remifentanil-isoflurane groups. However, the study had a low power for this comparison. When the data for the two anaesthetic combinations were pooled, the only significant effects were increases in diastolic arterial pressure and heart rate immediately after intubation; these were not seen 5 min after intubation. There were no cardiovascular responses to incision. There were no significant changes in the AER after intubation or incision.  (+info)

Postsurgical Candida albicans infections associated with an extrinsically contaminated intravenous anesthetic agent. (8/1774)

From 16 to 30 April 1990, four of 364 (1%) postsurgical patients at one hospital developed Candida albicans fungemia or endophthalmitis. The case patients' surgeries were clustered on two days. To identify risk factors for C. albicans infections, we conducted a cohort study comparing these 4 patients with 67 control patients who had surgeries on the same days but did not acquire C. albicans infections. The participation of anesthesiologist 9 (relative risk [RR], undefined; P < 0.001) and receipt of intravenous propofol, an anesthetic agent without preservative, which was administered by an infusion pump (RR, 8.8; P = 0.048) were identified as risk factors for C. albicans infections. The anesthetic had been recently introduced in the hospital. Hand cultures of 8 of 14 (57%) anesthesiologists were positive for Candida species; one yielded C. albicans. Anesthesiologist 9 was the only one to use stored syringes of propofol in the infusion pump and to reuse propofol syringes. DNA fingerprinting with a digoxigenin-labeled C. albicans repetitive element 2 probe and electrophoretic karyotyping showed two distinct banding patterns among patient isolates. We hypothesize that extrinsic contamination of propofol by anesthesiologist 9 likely resulted in C. albicans infections. These data suggest that strict aseptic techniques must be used when preparing and administering propofol.  (+info)

Propofol is a short-acting medication that is primarily used for the induction and maintenance of general anesthesia during procedures such as surgery. It belongs to a class of drugs called hypnotics or sedatives, which work by depressing the central nervous system to produce a calming effect. Propofol can also be used for sedation in mechanically ventilated patients in intensive care units and for procedural sedation in various diagnostic and therapeutic procedures outside the operating room.

The medical definition of Propofol is:
A rapid-onset, short-duration intravenous anesthetic agent that produces a hypnotic effect and is used for induction and maintenance of general anesthesia, sedation in mechanically ventilated patients, and procedural sedation. It acts by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain, leading to a decrease in neuronal activity and a reduction in consciousness. Propofol has a rapid clearance and distribution, allowing for quick recovery after discontinuation of its administration.

Intravenous anesthetics are a type of medication that is administered directly into a vein to cause a loss of consciousness and provide analgesia (pain relief) during medical procedures. They work by depressing the central nervous system, inhibiting nerve impulse transmission and ultimately preventing the patient from feeling pain or discomfort during surgery or other invasive procedures.

There are several different types of intravenous anesthetics, each with its own specific properties and uses. Some common examples include propofol, etomidate, ketamine, and barbiturates. These drugs may be used alone or in combination with other medications to provide a safe and effective level of anesthesia for the patient.

The choice of intravenous anesthetic depends on several factors, including the patient's medical history, the type and duration of the procedure, and the desired depth and duration of anesthesia. Anesthesiologists must carefully consider these factors when selecting an appropriate medication regimen for each individual patient.

While intravenous anesthetics are generally safe and effective, they can have side effects and risks, such as respiratory depression, hypotension, and allergic reactions. Anesthesia providers must closely monitor patients during and after the administration of these medications to ensure their safety and well-being.

Hypnotics and sedatives are classes of medications that have depressant effects on the central nervous system, leading to sedation (calming or inducing sleep), reduction in anxiety, and in some cases, decreased awareness or memory. These agents work by affecting the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, which results in inhibitory effects on neuronal activity.

Hypnotics are primarily used for the treatment of insomnia and other sleep disorders, while sedatives are often prescribed to manage anxiety or to produce a calming effect before medical procedures. Some medications can function as both hypnotics and sedatives, depending on the dosage and specific formulation. Common examples of these medications include benzodiazepines (such as diazepam and lorazepam), non-benzodiazepine hypnotics (such as zolpidem and eszopiclone), barbiturates, and certain antihistamines.

It is essential to use these medications under the guidance of a healthcare professional, as they can have potential side effects, such as drowsiness, dizziness, confusion, and impaired coordination. Additionally, long-term use or high doses may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Conscious sedation, also known as procedural sedation and analgesia, is a minimally depressed level of consciousness that retains the patient's ability to maintain airway spontaneously and respond appropriately to physical stimulation and verbal commands. It is typically achieved through the administration of sedative and/or analgesic medications and is commonly used in medical procedures that do not require general anesthesia. The goal of conscious sedation is to provide a comfortable and anxiety-free experience for the patient while ensuring their safety throughout the procedure.

Combined anesthetics refer to the use of two or more types of anesthetic agents together during a medical procedure to produce a desired level of sedation, amnesia, analgesia, and muscle relaxation. This approach can allow for lower doses of individual anesthetic drugs, which may reduce the risk of adverse effects associated with each drug. Common combinations include using a general anesthetic in combination with a regional or local anesthetic technique. The specific choice of combined anesthetics depends on various factors such as the type and duration of the procedure, patient characteristics, and the desired outcomes.

The anesthesia recovery period, also known as the post-anesthetic care unit (PACU) or recovery room stay, is the time immediately following anesthesia and surgery during which a patient's vital signs are closely monitored as they emerge from the effects of anesthesia.

During this period, the patient is typically observed for adequate ventilation, oxygenation, circulation, level of consciousness, pain control, and any potential complications. The length of stay in the recovery room can vary depending on the type of surgery, the anesthetic used, and the individual patient's needs.

The anesthesia recovery period is a critical time for ensuring patient safety and comfort as they transition from the surgical setting to full recovery. Nurses and other healthcare providers in the recovery room are specially trained to monitor and manage patients during this vulnerable period.

Thiopental, also known as Thiopentone, is a rapid-onset, ultrashort-acting barbiturate derivative. It is primarily used for the induction of anesthesia due to its ability to cause unconsciousness quickly and its short duration of action. Thiopental can also be used for sedation in critically ill patients, though this use has become less common due to the development of safer alternatives.

The drug works by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that produces a calming effect. This results in the depression of the central nervous system, leading to sedation, hypnosis, and ultimately, anesthesia.

It is worth noting that Thiopental has been largely replaced by newer drugs in many clinical settings due to its potential for serious adverse effects, such as cardiovascular and respiratory depression, as well as the risk of anaphylaxis. Additionally, it has been used in controversial procedures like capital punishment in some jurisdictions.

Inhalational anesthetics are a type of general anesthetic that is administered through the person's respiratory system. They are typically delivered in the form of vapor or gas, which is inhaled through a mask or breathing tube. Commonly used inhalational anesthetics include sevoflurane, desflurane, isoflurane, and nitrous oxide. These agents work by depressing the central nervous system, leading to a loss of consciousness and an inability to feel pain. They are often used for their rapid onset and offset of action, making them useful for both induction and maintenance of anesthesia during surgical procedures.

Methyl ethers are a type of organic compound where a methyl group (CH3-) is attached to an oxygen atom, which in turn is connected to another carbon atom. They are formed by the process of methylation, where a methyl group replaces a hydrogen atom in another molecule.

Methyl ethers can be found in various natural and synthetic substances. For example, dimethyl ether (CH3-O-CH3) is a common fuel used in refrigeration systems and as a propellant in aerosol sprays. Anisole (CH3-O-C6H5), another methyl ether, is found in anise oil and is used as a flavoring agent and solvent.

It's worth noting that some methyl ethers have been associated with potential health risks, particularly when they are volatile and can be inhaled or ingested. For example, exposure to high levels of dimethyl ether can cause respiratory irritation, headaches, and dizziness. Therefore, it's important to handle these substances with care and follow appropriate safety guidelines.

Alfentanil is a synthetic opioid analgesic drug that is chemically related to fentanyl. It is used for the provision of sedation and pain relief, particularly in critical care settings and during surgical procedures.

The medical definition of Alfentanil is as follows:

Alfentanil is a potent, short-acting opioid analgesic with a rapid onset of action. It is approximately 10 times more potent than morphine and has a rapid clearance rate due to its short elimination half-life of 1-2 hours. Alfentanil is used for the induction and maintenance of anesthesia, as well as for sedation and pain relief in critically ill patients. It works by binding to opioid receptors in the brain and spinal cord, which inhibits the transmission of pain signals and produces analgesia, sedation, and respiratory depression.

Like all opioids, Alfentanil carries a risk of dependence, tolerance, and respiratory depression, and should be used with caution in patients with respiratory or cardiovascular disease. It is typically administered by healthcare professionals in a controlled setting due to its potency and potential for adverse effects.

General anesthesia is a state of controlled unconsciousness, induced by administering various medications, that eliminates awareness, movement, and pain sensation during medical procedures. It involves the use of a combination of intravenous and inhaled drugs to produce a reversible loss of consciousness, allowing patients to undergo surgical or diagnostic interventions safely and comfortably. The depth and duration of anesthesia are carefully monitored and adjusted throughout the procedure by an anesthesiologist or certified registered nurse anesthetist (CRNA) to ensure patient safety and optimize recovery. General anesthesia is typically used for more extensive surgical procedures, such as open-heart surgery, major orthopedic surgeries, and neurosurgery.

Deep sedation, also known as general anesthesia, is a drug-induced depression of consciousness during which patients cannot be easily aroused but respond purposefully following repeated or painful stimulation. It is characterized by the loss of protective reflexes such as cough and gag, and the ability to ventilate spontaneously may be impaired. Patients may require assistance in maintaining a patent airway, and positive pressure ventilation may be required.

Deep sedation/general anesthesia is typically used for surgical procedures or other medical interventions that require patients to be completely unaware and immobile, and it is administered by trained anesthesia professionals who monitor and manage the patient's vital signs and level of consciousness throughout the procedure.

Intraoperative monitoring (IOM) is the practice of using specialized techniques to monitor physiological functions or neural structures in real-time during surgical procedures. The primary goal of IOM is to provide continuous information about the patient's status and the effects of surgery on neurological function, allowing surgeons to make informed decisions and minimize potential risks.

IOM can involve various methods such as:

1. Electrophysiological monitoring: This includes techniques like somatosensory evoked potentials (SSEP), motor evoked potentials (MEP), and electroencephalography (EEG) to assess the integrity of neural pathways and brain function during surgery.
2. Neuromonitoring: Direct electrical stimulation of nerves or spinal cord structures can help identify critical neuroanatomical structures, evaluate their functional status, and guide surgical interventions.
3. Hemodynamic monitoring: Measuring blood pressure, heart rate, cardiac output, and oxygen saturation helps assess the patient's overall physiological status during surgery.
4. Imaging modalities: Intraoperative imaging techniques like ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) can provide real-time visualization of anatomical structures and surgical progress.

The specific IOM methods employed depend on the type of surgery, patient characteristics, and potential risks involved. Intraoperative monitoring is particularly crucial in procedures where there is a risk of neurological injury, such as spinal cord or brain surgeries, vascular interventions, or tumor resections near critical neural structures.

Midazolam is a medication from the class of drugs known as benzodiazepines. It works by enhancing the effect of a neurotransmitter called gamma-aminobutyric acid (GABA), which has a calming effect on the brain and nervous system. Midazolam is often used for its sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties.

Medically, midazolam is used for various purposes, including:

1. Preoperative medication (sedation before surgery)
2. Procedural sedation (for minor surgical or diagnostic procedures)
3. Treatment of seizures (status epilepticus)
4. Sedation in critically ill patients
5. As an adjunct to anesthesia during surgeries
6. Treatment of alcohol withdrawal symptoms
7. To induce amnesia for certain medical or dental procedures

Midazolam is available in various forms, such as tablets, intravenous (IV) solutions, and intranasal sprays. It has a rapid onset of action and a short duration, making it suitable for brief, intermittent procedures. However, midazolam can cause side effects like drowsiness, confusion, respiratory depression, and memory impairment. Therefore, its use should be carefully monitored by healthcare professionals.

Etomidate is a intravenous anesthetic medication used for the induction of general anesthesia. It provides a rapid and smooth induction with minimal cardiovascular effects, making it a popular choice in patients with hemodynamic instability. Etomidate also has antiseizure properties. However, its use is associated with adrenal suppression, which can lead to complications such as hypotension and impaired stress response. Therefore, its use is generally avoided in critically ill or septic patients.

The medical definition of 'Etomidate' is:

A carboxylated imidazole derivative that is used as an intravenous anesthetic for the induction of general anesthesia. It has a rapid onset of action and minimal cardiovascular effects, making it useful in patients with hemodynamic instability. Etomidate also has antiseizure properties. However, its use is associated with adrenal suppression, which can lead to complications such as hypotension and impaired stress response. Therefore, its use is generally avoided in critically ill or septic patients.

Methohexital is a rapidly acting barbiturate sedative-hypnotic agent primarily used for the induction of anesthesia. It is a short-acting drug, with an onset of action of approximately one minute and a duration of action of about 5 to 10 minutes. Methohexital is highly lipid soluble, which allows it to rapidly cross the blood-brain barrier and produce a rapid and profound sedative effect.

Methohexital is administered intravenously and works by depressing the central nervous system (CNS), producing a range of effects from mild sedation to general anesthesia. At lower doses, it can cause drowsiness, confusion, and amnesia, while at higher doses, it can lead to unconsciousness and suppression of respiratory function.

Methohexital is also used for diagnostic procedures that require sedation, such as electroconvulsive therapy (ECT) and cerebral angiography. It is not commonly used outside of hospital or clinical settings due to its potential for serious adverse effects, including respiratory depression, cardiovascular instability, and anaphylaxis.

It's important to note that Methohexital should only be administered by trained medical professionals under close supervision, as it requires careful titration to achieve the desired level of sedation while minimizing the risk of adverse effects.

Fentanyl is a potent synthetic opioid analgesic, which is similar to morphine but is 50 to 100 times more potent. It is a schedule II prescription drug, typically used to treat patients with severe pain or to manage pain after surgery. It works by binding to the body's opioid receptors, which are found in the brain, spinal cord, and other areas of the body.

Fentanyl can be administered in several forms, including transdermal patches, lozenges, injectable solutions, and tablets that dissolve in the mouth. Illegally manufactured and distributed fentanyl has also become a major public health concern, as it is often mixed with other drugs such as heroin, cocaine, and counterfeit pills, leading to an increase in overdose deaths.

Like all opioids, fentanyl carries a risk of dependence, addiction, and overdose, especially when used outside of medical supervision or in combination with other central nervous system depressants such as alcohol or benzodiazepines. It is important to use fentanyl only as directed by a healthcare provider and to be aware of the potential risks associated with its use.

I'm not aware of a specific medical definition for "consciousness monitors." The term "consciousness" generally refers to an individual's state of being awake and aware of their surroundings and experiences. In a medical context, healthcare professionals may monitor a person's level of consciousness as part of their overall assessment of the patient's neurological status.

There are several tools and scales that healthcare providers use to assess a person's level of consciousness, including:

1. The Glasgow Coma Scale (GCS): This is a widely used tool for assessing level of consciousness in patients with traumatic brain injury or other conditions that may affect consciousness. The GCS evaluates a patient's ability to open their eyes, speak, and move in response to stimuli.
2. The Alert, Voice, Pain, Unresponsive (AVPU) scale: This is another tool used to assess level of consciousness. It evaluates whether a patient is alert, responds to voice, responds to pain, or is unresponsive.
3. Pupillary response: Healthcare providers may also monitor the size and reactivity of a person's pupils as an indicator of their level of consciousness. Changes in pupil size or reactivity can be a sign of brainstem dysfunction or increased intracranial pressure.

It's important to note that while healthcare professionals may monitor a patient's level of consciousness, there is no single device or tool that can directly measure "consciousness" itself. Instead, these tools and assessments provide valuable information about a person's neurological status and help healthcare providers make informed decisions about their care.

General anesthetics are a type of medication used to render a person unconscious and insensible to pain during surgical procedures. They work by depressing the central nervous system, affecting the brain's ability to process information and transmit signals, including those related to pain and muscle movement. General anesthesia involves a combination of intravenous (IV) drugs and inhaled gases that produce a state of controlled unconsciousness, amnesia, analgesia, and immobility.

General anesthetics can be classified into several categories based on their chemical structure and mechanism of action, including:

1. Inhalation anesthetics: These are volatile liquids or gases that are vaporized and inhaled through a breathing circuit. Examples include sevoflurane, desflurane, isoflurane, and nitrous oxide.
2. Intravenous anesthetics: These are drugs that are administered directly into the bloodstream through an IV line. Examples include propofol, etomidate, and ketamine.
3. Dissociative anesthetics: These are drugs that produce a state of dissociation between the thalamus and the cerebral cortex, resulting in altered consciousness, analgesia, and amnesia. Ketamine is a commonly used example.
4. Neurodegenerative anesthetics: These are drugs that cause degeneration of neurons in specific areas of the brain, leading to loss of consciousness. Examples include barbiturates such as thiopental and methohexital.

The choice of general anesthetic depends on several factors, including the patient's medical history, the type and duration of surgery, and the anesthesiologist's preference. The administration of general anesthetics requires careful monitoring and management by a trained anesthesia provider to ensure the patient's safety and comfort throughout the procedure.

Electroencephalography (EEG) is a medical procedure that records electrical activity in the brain. It uses small, metal discs called electrodes, which are attached to the scalp with paste or a specialized cap. These electrodes detect tiny electrical charges that result from the activity of brain cells, and the EEG machine then amplifies and records these signals.

EEG is used to diagnose various conditions related to the brain, such as seizures, sleep disorders, head injuries, infections, and degenerative diseases like Alzheimer's or Parkinson's. It can also be used during surgery to monitor brain activity and ensure that surgical procedures do not interfere with vital functions.

EEG is a safe and non-invasive procedure that typically takes about 30 minutes to an hour to complete, although longer recordings may be necessary in some cases. Patients are usually asked to relax and remain still during the test, as movement can affect the quality of the recording.

Anesthetics are medications that are used to block or reduce feelings of pain and sensation, either locally in a specific area of the body or generally throughout the body. They work by depressing the nervous system, interrupting the communication between nerves and the brain. Anesthetics can be administered through various routes such as injection, inhalation, or topical application, depending on the type and the desired effect. There are several classes of anesthetics, including:

1. Local anesthetics: These numb a specific area of the body and are commonly used during minor surgical procedures, dental work, or to relieve pain from injuries. Examples include lidocaine, prilocaine, and bupivacaine.
2. Regional anesthetics: These block nerve impulses in a larger area of the body, such as an arm or leg, and can be used for more extensive surgical procedures. They are often administered through a catheter to provide continuous pain relief over a longer period. Examples include spinal anesthesia, epidural anesthesia, and peripheral nerve blocks.
3. General anesthetics: These cause a state of unconsciousness and are used for major surgical procedures or when the patient needs to be completely immobile during a procedure. They can be administered through inhalation or injection and affect the entire body. Examples include propofol, sevoflurane, and isoflurane.

Anesthetics are typically safe when used appropriately and under medical supervision. However, they can have side effects such as drowsiness, nausea, and respiratory depression. Proper dosing and monitoring by a healthcare professional are essential to minimize the risks associated with anesthesia.

Anesthesia is a medical term that refers to the loss of sensation or awareness, usually induced by the administration of various drugs. It is commonly used during surgical procedures to prevent pain and discomfort. There are several types of anesthesia, including:

1. General anesthesia: This type of anesthesia causes a complete loss of consciousness and is typically used for major surgeries.
2. Regional anesthesia: This type of anesthesia numbs a specific area of the body, such as an arm or leg, while the patient remains conscious.
3. Local anesthesia: This type of anesthesia numbs a small area of the body, such as a cut or wound, and is typically used for minor procedures.

Anesthesia can be administered through various routes, including injection, inhalation, or topical application. The choice of anesthesia depends on several factors, including the type and duration of the procedure, the patient's medical history, and their overall health. Anesthesiologists are medical professionals who specialize in administering anesthesia and monitoring patients during surgical procedures to ensure their safety and comfort.

Isoflurane is a volatile halogenated ether used for induction and maintenance of general anesthesia. It is a colorless liquid with a pungent, sweet odor. Isoflurane is an agonist at the gamma-aminobutyric acid type A (GABAA) receptor and inhibits excitatory neurotransmission in the brain, leading to unconsciousness and immobility. It has a rapid onset and offset of action due to its low blood solubility, allowing for quick adjustments in anesthetic depth during surgery. Isoflurane is also known for its bronchodilator effects, making it useful in patients with reactive airway disease. However, it can cause dose-dependent decreases in heart rate and blood pressure, so careful hemodynamic monitoring is required during its use.

Nitrous oxide, also known as laughing gas, is a colorless and non-flammable gas with a slightly sweet odor and taste. In medicine, it's commonly used for its anesthetic and pain reducing effects. It is often used in dental procedures, surgery, and childbirth to help reduce anxiety and provide mild sedation. Nitrous oxide works by binding to the hemoglobin in red blood cells, which reduces the oxygen-carrying capacity of the blood, but this effect is usually not significant at the low concentrations used for analgesia and anxiolysis. It's also considered relatively safe when administered by a trained medical professional because it does not cause depression of the respiratory system or cardiovascular function.

Consciousness is a complex and multifaceted concept that is difficult to define succinctly, but in a medical or neurological context, it generally refers to an individual's state of awareness and responsiveness to their surroundings. Consciousness involves a range of cognitive processes, including perception, thinking, memory, and attention, and it requires the integration of sensory information, language, and higher-order cognitive functions.

In medical terms, consciousness is often assessed using measures such as the Glasgow Coma Scale, which evaluates an individual's ability to open their eyes, speak, and move in response to stimuli. A coma is a state of deep unconsciousness where an individual is unable to respond to stimuli or communicate, while a vegetative state is a condition where an individual may have sleep-wake cycles and some automatic responses but lacks any meaningful awareness or cognitive function.

Disorders of consciousness can result from brain injury, trauma, infection, or other medical conditions that affect the functioning of the brainstem or cerebral cortex. The study of consciousness is a rapidly evolving field that involves researchers from various disciplines, including neuroscience, psychology, philosophy, and artificial intelligence.

Piperidines are not a medical term per se, but they are a class of organic compounds that have important applications in the pharmaceutical industry. Medically relevant piperidines include various drugs such as some antihistamines, antidepressants, and muscle relaxants.

A piperidine is a heterocyclic amine with a six-membered ring containing five carbon atoms and one nitrogen atom. The structure can be described as a cyclic secondary amine. Piperidines are found in some natural alkaloids, such as those derived from the pepper plant (Piper nigrum), which gives piperidines their name.

In a medical context, it is more common to encounter specific drugs that belong to the class of piperidines rather than the term itself.

A dose-response relationship in the context of drugs refers to the changes in the effects or symptoms that occur as the dose of a drug is increased or decreased. Generally, as the dose of a drug is increased, the severity or intensity of its effects also increases. Conversely, as the dose is decreased, the effects of the drug become less severe or may disappear altogether.

The dose-response relationship is an important concept in pharmacology and toxicology because it helps to establish the safe and effective dosage range for a drug. By understanding how changes in the dose of a drug affect its therapeutic and adverse effects, healthcare providers can optimize treatment plans for their patients while minimizing the risk of harm.

The dose-response relationship is typically depicted as a curve that shows the relationship between the dose of a drug and its effect. The shape of the curve may vary depending on the drug and the specific effect being measured. Some drugs may have a steep dose-response curve, meaning that small changes in the dose can result in large differences in the effect. Other drugs may have a more gradual dose-response curve, where larger changes in the dose are needed to produce significant effects.

In addition to helping establish safe and effective dosages, the dose-response relationship is also used to evaluate the potential therapeutic benefits and risks of new drugs during clinical trials. By systematically testing different doses of a drug in controlled studies, researchers can identify the optimal dosage range for the drug and assess its safety and efficacy.

Intravenous (IV) infusion is a medical procedure in which liquids, such as medications, nutrients, or fluids, are delivered directly into a patient's vein through a needle or a catheter. This route of administration allows for rapid absorption and distribution of the infused substance throughout the body. IV infusions can be used for various purposes, including resuscitation, hydration, nutrition support, medication delivery, and blood product transfusion. The rate and volume of the infusion are carefully controlled to ensure patient safety and efficacy of treatment.

**Ketamine** is a dissociative anesthetic medication primarily used for starting and maintaining anesthesia. It can lead to a state of altered perception, hallucinations, sedation, and memory loss. Ketamine is also used as a pain reliever in patients with chronic pain conditions and during certain medical procedures due to its strong analgesic properties.

It is available as a generic drug and is also sold under various brand names, such as Ketalar, Ketanest, and Ketamine HCl. It can be administered intravenously, intramuscularly, orally, or as a nasal spray.

In addition to its medical uses, ketamine has been increasingly used off-label for the treatment of mood disorders like depression, anxiety, and post-traumatic stress disorder (PTSD), owing to its rapid antidepressant effects. However, more research is needed to fully understand its long-term benefits and risks in these applications.

It's important to note that ketamine can be abused recreationally due to its dissociative and hallucinogenic effects, which may lead to addiction and severe psychological distress. Therefore, it should only be used under the supervision of a medical professional.

Dissociative anesthetics are a class of drugs that produce a state of altered consciousness, characterized by a sense of detachment or dissociation from the environment and oneself. These drugs work by disrupting the normal communication between the brain's thalamus and cortex, which can lead to changes in perception, thinking, and emotion.

Some examples of dissociative anesthetics include ketamine, phencyclidine (PCP), and dextromethorphan (DXM). These drugs can produce a range of effects, including sedation, analgesia, amnesia, and hallucinations. At high doses, they can cause profound dissociative states, in which individuals may feel as though they are outside their own bodies or that the world around them is not real.

Dissociative anesthetics are used medically for a variety of purposes, including as general anesthetics during surgery, as sedatives for diagnostic procedures, and as treatments for chronic pain and depression. However, they also have a high potential for abuse and can produce significant negative health effects when taken recreationally.

Unconsciousness is a state of complete awareness where a person is not responsive to stimuli and cannot be awakened. It is often caused by severe trauma, illness, or lack of oxygen supply to the brain. In medical terms, it is defined as a lack of response to verbal commands, pain, or other stimuli, indicating that the person's brain is not functioning at a level necessary to maintain wakefulness and awareness.

Unconsciousness can be described as having different levels, ranging from drowsiness to deep coma. The causes of unconsciousness can vary widely, including head injury, seizure, stroke, infection, drug overdose, or lack of oxygen supply to the brain. Depending on the cause and severity, unconsciousness may last for a few seconds or continue for an extended period, requiring medical intervention and treatment.

An adjuvant in anesthesia refers to a substance or drug that is added to an anesthetic medication to enhance its effects, make it last longer, or improve the overall quality of anesthesia. Adjuvants do not produce analgesia or anesthesia on their own but work synergistically with other anesthetics to achieve better clinical outcomes.

There are several types of adjuvants used in anesthesia, including:

1. Opioids: These are commonly used adjuvants that enhance the analgesic effect of anesthetic drugs. Examples include fentanyl, sufentanil, and remifentanil.
2. Alpha-2 agonists: Drugs like clonidine and dexmedetomidine are used as adjuvants to provide sedation, analgesia, and anxiolysis. They also help reduce the requirement for other anesthetic drugs, thus minimizing side effects.
3. Ketamine: This NMDA receptor antagonist is used as an adjuvant to provide analgesia and amnesia. It can be used in subanesthetic doses to improve the quality of analgesia during general anesthesia or as a sole anesthetic for procedural sedation.
4. Local anesthetics: When used as an adjuvant, local anesthetics can prolong the duration of postoperative analgesia and reduce the requirement for opioids. Examples include bupivacaine, ropivacaine, and lidocaine.
5. Neostigmine: This cholinesterase inhibitor is used as an adjuvant to reverse the neuromuscular blockade produced by non-depolarizing muscle relaxants at the end of surgery.
6. Dexamethasone: A corticosteroid used as an adjuvant to reduce postoperative nausea and vomiting, inflammation, and pain.
7. Magnesium sulfate: This non-competitive NMDA receptor antagonist is used as an adjuvant to provide analgesia, reduce opioid consumption, and provide neuroprotection in certain surgical settings.

The choice of adjuvants depends on the type of surgery, patient factors, and the desired clinical effects.

An emulsion is a type of stable mixture of two immiscible liquids, such as oil and water, which are normally unable to mix together uniformly. In an emulsion, one liquid (the dispersed phase) is broken down into small droplets and distributed throughout the other liquid (the continuous phase), creating a stable, cloudy mixture.

In medical terms, emulsions can be used in various pharmaceutical and cosmetic applications. For example, certain medications may be formulated as oil-in-water or water-in-oil emulsions to improve their absorption, stability, or palatability. Similarly, some skincare products and makeup removers contain emulsifiers that help create stable mixtures of water and oils, allowing for effective cleansing and moisturizing.

Emulsions can also occur naturally in the body, such as in the digestion of fats. The bile salts produced by the liver help to form small droplets of dietary lipids (oil) within the watery environment of the small intestine, allowing for efficient absorption and metabolism of these nutrients.

An infusion pump is a medical device used to deliver fluids, such as medications, nutrients, or supplements, into a patient's body in a controlled and precise manner. These pumps can be programmed to deliver specific amounts of fluid over set periods, allowing for accurate and consistent administration. They are often used in hospitals, clinics, and home care settings to administer various types of therapies, including pain management, chemotherapy, antibiotic treatment, and parenteral nutrition.

Infusion pumps come in different sizes and configurations, with some being portable and battery-operated for use outside of a medical facility. They typically consist of a reservoir for the fluid, a pumping mechanism to move the fluid through tubing and into the patient's body, and a control system that allows healthcare professionals to program the desired flow rate and volume. Some advanced infusion pumps also include safety features such as alarms to alert healthcare providers if there are any issues with the pump's operation or if the patient's condition changes unexpectedly.

Ambulatory surgical procedures, also known as outpatient or same-day surgery, refer to medical operations that do not require an overnight hospital stay. These procedures are typically performed in a specialized ambulatory surgery center (ASC) or in a hospital-based outpatient department. Patients undergoing ambulatory surgical procedures receive anesthesia, undergo the operation, and recover enough to be discharged home on the same day of the procedure.

Examples of common ambulatory surgical procedures include:

1. Arthroscopy (joint scope examination and repair)
2. Cataract surgery
3. Colonoscopy and upper endoscopy
4. Dental surgery, such as wisdom tooth extraction
5. Gallbladder removal (cholecystectomy)
6. Hernia repair
7. Hysteroscopy (examination of the uterus)
8. Minor skin procedures, like biopsies and lesion removals
9. Orthopedic procedures, such as carpal tunnel release or joint injections
10. Pain management procedures, including epidural steroid injections and nerve blocks
11. Podiatric (foot and ankle) surgery
12. Tonsillectomy and adenoidectomy

Advancements in medical technology, minimally invasive surgical techniques, and improved anesthesia methods have contributed to the growth of ambulatory surgical procedures, offering patients a more convenient and cost-effective alternative to traditional inpatient surgeries.

Preanesthetic medication, also known as premedication, refers to the administration of medications before anesthesia to help prepare the patient for the upcoming procedure. These medications can serve various purposes, such as:

1. Anxiolysis: Reducing anxiety and promoting relaxation in patients before surgery.
2. Amnesia: Causing temporary memory loss to help patients forget the events leading up to the surgery.
3. Analgesia: Providing pain relief to minimize discomfort during and after the procedure.
4. Antisialagogue: Decreasing saliva production to reduce the risk of aspiration during intubation.
5. Bronchodilation: Relaxing bronchial smooth muscles, which can help improve respiratory function in patients with obstructive lung diseases.
6. Antiemetic: Preventing or reducing the likelihood of postoperative nausea and vomiting.
7. Sedation: Inducing a state of calmness and drowsiness to facilitate a smooth induction of anesthesia.

Common preanesthetic medications include benzodiazepines (e.g., midazolam), opioids (e.g., fentanyl), anticholinergics (e.g., glycopyrrolate), and H1-antihistamines (e.g., diphenhydramine). The choice of preanesthetic medication depends on the patient's medical history, comorbidities, and the type of anesthesia to be administered.

Inhalational anesthesia is a type of general anesthesia that is induced by the inhalation of gases or vapors. It is administered through a breathing system, which delivers the anesthetic agents to the patient via a face mask, laryngeal mask airway, or endotracheal tube.

The most commonly used inhalational anesthetics include nitrous oxide, sevoflurane, isoflurane, and desflurane. These agents work by depressing the central nervous system, causing a reversible loss of consciousness, amnesia, analgesia, and muscle relaxation.

The depth of anesthesia can be easily adjusted during the procedure by changing the concentration of the anesthetic agent. Once the procedure is complete, the anesthetic agents are eliminated from the body through exhalation, allowing for a rapid recovery.

Inhalational anesthesia is commonly used in a wide range of surgical procedures due to its ease of administration, quick onset and offset of action, and ability to rapidly adjust the depth of anesthesia. However, it requires careful monitoring and management by trained anesthesia providers to ensure patient safety and optimize outcomes.

Intubation, intratracheal is a medical procedure in which a flexible plastic or rubber tube called an endotracheal tube (ETT) is inserted through the mouth or nose, passing through the vocal cords and into the trachea (windpipe). This procedure is performed to establish and maintain a patent airway, allowing for the delivery of oxygen and the removal of carbon dioxide during mechanical ventilation in various clinical scenarios, such as:

1. Respiratory failure or arrest
2. Procedural sedation
3. Surgery under general anesthesia
4. Neuromuscular disorders
5. Ingestion of toxic substances
6. Head and neck trauma
7. Critical illness or injury affecting the airway

The process of intubation is typically performed by trained medical professionals, such as anesthesiologists, emergency medicine physicians, or critical care specialists, using direct laryngoscopy or video laryngoscopy to visualize the vocal cords and guide the ETT into the correct position. Once placed, the ETT is secured to prevent dislodgement, and the patient's respiratory status is continuously monitored to ensure proper ventilation and oxygenation.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever. It works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. Diclofenac is available in various forms, including tablets, capsules, suppositories, topical creams, gels, and patches.

The medical definition of Diclofenac is:

Diclofenac sodium: A sodium salt of diclofenac, a phenylacetic acid derivative that is a potent inhibitor of prostaglandin synthesis. It is used in the treatment of inflammation and pain in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other conditions. Diclofenac sodium has also been used to treat actinic keratosis, a precancerous skin condition. It is available by prescription in various forms, including oral tablets, capsules, topical creams, gels, and patches.

"Medicine in Art" is not a medical term per se, but rather a term used to describe the intersection and representation of medical themes, practices, or symbols in various art forms. It can include but is not limited to:

1. The depiction of medical scenes, practitioners, or patients in paintings, sculptures, or photographs.
2. The use of medical imagery such as X-rays, MRIs, or anatomical drawings in mixed media works.
3. The exploration of medical issues, diseases, or treatments in conceptual art.
4. The creation of art by artists with medical conditions, which can provide insight into their experiences.
5. The use of art therapy as a healing modality in medical settings.

This term is often used in the context of art history, visual culture, and medical humanities to analyze and understand the complex relationships between art, medicine, and society.

Pain measurement, in a medical context, refers to the quantification or evaluation of the intensity and/or unpleasantness of a patient's subjective pain experience. This is typically accomplished through the use of standardized self-report measures such as numerical rating scales (NRS), visual analog scales (VAS), or categorical scales (mild, moderate, severe). In some cases, physiological measures like heart rate, blood pressure, and facial expressions may also be used to supplement self-reported pain ratings. The goal of pain measurement is to help healthcare providers better understand the nature and severity of a patient's pain in order to develop an effective treatment plan.

The double-blind method is a study design commonly used in research, including clinical trials, to minimize bias and ensure the objectivity of results. In this approach, both the participants and the researchers are unaware of which group the participants are assigned to, whether it be the experimental group or the control group. This means that neither the participants nor the researchers know who is receiving a particular treatment or placebo, thus reducing the potential for bias in the evaluation of outcomes. The assignment of participants to groups is typically done by a third party not involved in the study, and the codes are only revealed after all data have been collected and analyzed.

... is believed to work at least partly via a receptor for GABA. Propofol was first synthesized in 1977 and approved for ... Propofol can be run through a peripheral IV or central line. Propofol is frequently paired with fentanyl (for pain relief) in ... "Propofol-Lipuro 1% (propofol) Injectable emulsion for infusion - 1,000 mg in 100 ml (10 mg /ml) : Fact Sheet for health Care ... Propofol is also used in veterinary medicine for anesthesia. To induce general anesthesia, propofol is the drug used almost ...
It is associated with high doses and long-term use of propofol (> 4 mg/kg/h for more than 24 hours). It occurs more commonly in ... Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of ... PRIS is a rare complication of propofol infusion. It is generally associated with high doses (>4 mg/kg per hour or >67 mcg/kg ... McKeage, K; Perry, CM (2003). "Propofol: a review of its use in intensive care sedation of adults". CNS Drugs. 17 (4): 235-72. ...
In the elderly, the rate of Propofol clearance is low. Therefore, lower doses of Propofol (50 to 100 mg) should be given. It is ... At prolonged high Propofol dosages, it can induce Propofol infusion syndrome, characterized by acute refractory bradycardia ... For those with bronchospasm, Propofol also has mild bronchodilating effect. However, Propofol can induce hypotension and ... Propofol - It is a highly lipid-soluble, GABA agonist. The dosage is 1.5 mg/kg (usually 100 to 200 mg). It has quick onset of ...
Propofol (Diprivan, Propoven) is a commonly used intravenous sedative. Because it is only slightly soluble in water, it is ... "Propofol". Drugs.com. 6 July 2019. Retrieved 28 November 2019. Dewachter P, Kopac P, Laguna JJ, Mertes PM, Sabato V, Volcheck ... "Diprivan (propofol) Injectable Emulsion, USP". RxList. Retrieved 2 November 2019. Thanai Pongdee (2019). "Soy-allergenic and ... and the vast majority of people with known soy or egg allergies do not have a reaction to propofol. Protein contact dermatitis ...
May 1998). "Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and ... Krasowski MD, Hong X, Hopfinger AJ, Harrison NL (July 2002). "4D-QSAR analysis of a set of propofol analogues: mapping binding ... 4-Iodopropofol has similar effects to propofol on isolated receptors, acting primarily as a GABAA positive modulator and sodium ... 4-Iodopropofol is a drug derived from the commonly used sedative anaesthetic agent, propofol. ...
Propofol is given intravenously. It has been used in an acute care setting in hospital as a rescue therapy for emesis. ... "Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and ...
Propofol also inhibits HCN1. Isoflurane and Sevoflurane inhibit HCN1. HCN1 has been shown to interact with HCN2. De novo ... Bojak I, Day HC, Liley DT (2013). "Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions". ...
Park, Hyun-min; Jeon, Su-mi (13 March 2013). "Lee Seung Yeon, Park Si Yeon and Jang Mi In Ae to be Indicted for Propofol Abuse ... The Seoul Central District Court found Jang guilty of taking propofol 410 times over six years (or 5.6 times a month), and she ... Jeon, Su-mi (24 January 2013). "Actresses Jang Mi In Ae and Lee Seung Yeon Suspected of Propofol Abuse". enewsWorld. CJ E&M. ... Lee, Kyung-min (20 May 2013). "Propofol scandal might not be true". The Korea Times. Archived from the original on 2 November ...
Bray RJ (1998). "Propofol infusion syndrome in children". Pediatric Anesthesia. 8 (6): 491-9. doi:10.1046/j.1460-9592.1998. ... in children using propofol (Diprivan) Depression or hepatic injury caused by interferon Diabetes caused by atypical ...
Baker, Max T.; Naguib, Mohamed (1 October 2005). "Propofol: The Challenges of Formulation". Anesthesiology: The Journal of the ... propofol (1977, an intravenous anaesthetic agent), Inderal (1965, a beta-blocker), tamoxifen (1978, a frequently used drug for ...
Lee admitted taking propofol, but said it was legally prescribed by her doctor to treat a spinal fracture diagnosed in 2003, ... The Seoul Central District Court found Lee guilty of taking propofol at least 320 times over six years (or 4.5 times a month), ... In 2013, she became involved in another controversy when she was indicted for illegal use of the drug propofol. Cable channel ... Lee, Jin-ho; Park, Hyun-min (24 January 2013). "Jang Mi In Ae and Lee Seung Yeon Officially Deny Propofol Suspicions". ...
Propofol is now used worldwide with a well-defined pharmacological profile for a variety of medical uses. TIVA is used to ... Propofol (di-isopropyl phenol) was synthesized by Glen and colleagues in the early 1970s, but its first formulations were ... Propofol is usually the selected sedative-hypnotic agent to maintain general anesthesia through TIVA because of its rapid onset ... Propofol, etomidate and ketamine are common intravenous sedative-hypnotic agents for the induction of TIVA. Their highly ...
Doheny, Kathleen (August 24, 2009). "Propofol Linked to Michael Jackson's Death". WebMD. Retrieved May 31, 2015. Rawlinson, ...
Doheny, Kathleen (August 24, 2009). "Propofol Linked to Michael Jackson's Death". WebMD. Retrieved May 31, 2015. Rawlinson, ...
Veselis RA (March 2006). "The remarkable memory effects of propofol". British Journal of Anaesthesia. 96 (3): 289-91. doi: ... November 2004). "The effects of propofol, small-dose isoflurane, and nitrous oxide on cortical somatosensory evoked potential ...
Murray had administered propofol, lorazepam, and midazolam; his death was caused by a propofol overdose. News of his death ... In 2009, while he was preparing for a series of comeback concerts, This Is It, Jackson died from an overdose of propofol ... Doheny, Kathleen (August 24, 2009). "Propofol Linked to Michael Jackson's Death". WebMD. Retrieved May 31, 2015. Rawlinson, ... caused by a propofol and benzodiazepine overdose. Conrad Murray, his personal physician, had given Jackson various medications ...
It is structurally similar to propofol. There are several methods for purifying and isolating honokiol. In nature, honokiol ...
In 2011, he admitted to Dr Drew on CNN that he had administered propofol twice to Michael Jackson during aesthetic procedures. ... Drew exclusive: Cosmetic doc says he also used propofol on MJ". HLN. Archived from the original on 7 March 2016. Retrieved 28 ... "Cosmetic doc gave MJ propofol twice". CNN/. (Articles with short description, Short description matches Wikidata, ...
... the DEA stated they would consider labelling propofol a controlled substance. In 2010 the agency recommended adding propofol to ... Propofol became known as the 'Michael Jackson Drug' among patients and many of them had reservations about it after Jackson's ... The propofol was administered in a non-hospital setting without any appropriate medical indication. The standard of care for ... Murray said he had given Jackson propofol "virtually every day" for a little more than two months. He said Jackson had told him ...
De Cosmo G, Congedo E, Clemente A, Aceto P (November 2005). "Sedation in PACU: the role of propofol". Current Drug Targets. 6 ( ... Cox CE, Reed SD, Govert JA, Rodgers JE, Campbell-Bright S, Kress JP, Carson SS (March 2008). "Economic evaluation of propofol ... Midazolam is superior to diazepam in impairing memory of endoscopy procedures, but propofol has a quicker recovery time and a ... However, for long-term sedation, lorazepam is preferred due to its long duration of action, and propofol has advantages over ...
Other GABAergic modulators include: GABAB receptor ligands.[citation needed] Agonists: baclofen, propofol, GHB, phenibut. ...
Accordingly, propofol is supposed to be administered on the orders of an anesthesiologist, critical care physician (intensivist ... On June 25, 2009, only weeks after hiring Murray, Michael Jackson died due to a lethal dose of propofol administered by Murray ... He claimed that he tried treating him with other drugs and that he only administered the propofol after Jackson insisted, ... Based on the autopsy and toxicology findings, the cause of Jackson's death was determined to be acute propofol intoxication ...
Park, Hyun-min; Jeon, Su-mi (March 13, 2013). "Lee Seung Yeon, Park Si Yeon and Jang Mi In Ae to be Indicted for Propofol Abuse ... In October 2013, the Seoul Central District Court found Park guilty of taking propofol 400-500 times over four-and-a-half years ... An, So-hyoun (May 20, 2013). "Doctor States Park Si Yeon was Treated with Propofol Due to a Rare Disease". enewsWorld. Archived ... After giving birth and being indicted for propofol use in 2013, Park returned to television with the 2014 cable drama The ...
The BIS is an electroencephalogram-derived multivariant scale that, when a drug such a propofol is used, correlates with the ... Flaishon R, Windsor A, Sigl J, Sebel PS (March 1997). "Recovery of consciousness after thiopental or propofol. Bispectral index ... and discharge from the operating room and PACU Reduced risk of postoperative nausea and vomiting Reducing the use of propofol ...
see details on pad placement below). The anesthesiology team will then administer a general anesthetic (e.g., Propofol) in ... Wafae BG, da Silva RM, Veloso HH (2019). "Propofol for sedation for direct current cardioversion". Annals of Cardiac ... Opioid analgesics (e.g., Fentanyl) may be combined with Propofol, although anesthesiology must weight the benefits against ... the effects of Propofol generally last for only 3-8 minutes). However, if the arrhythmia is persistent, the machine may be re- ...
Hui TW, Short TG, Hong W, Suen T, Gin T, Plummer J (March 1995). "Additive interactions between propofol and ketamine when used ... Ketofol is a combination of ketamine and propofol. Ketamine is frequently used in severely injured people and appears to be ... Vomiting can be expected in 5-15% of the patients; pretreatment with propofol mitigates it as well. Laryngospasm occurs only ... Zhao Y, Sun L (November 2008). "Antidepressants modulate the in vitro inhibitory effects of propofol and ketamine on ...
Matsukawa T, Kurz A, Sessler DI, Bjorksten AR, Merrifield B, Cheng C (1995). "Propofol linearly reduces the vasoconstriction ... Leslie K, Sessler DI, Bjorksten AR, Moayeri A (1995). "Mild hypothermia alters propofol pharmacokinetics and increases the ...
It can be mixed with propofol in the same syringe. The combination appears to be safer than propofol by itself when used for ... Jalili M, Bahreini M, Doosti-Irani A, Masoomi R, Arbab M, Mirfazaelian H (March 2016). "Ketamine-propofol combination (ketofol ... Willman EV, Andolfatto G (January 2007). "A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural ... Ketofol is a mixture of ketamine and propofol. Both drugs are anesthetic agents. ...
Ativan would cause the patient to have slurred speech but propofol would not, it is "quick onset, quick offset." Propofol is ... containing an array of bottles that included 100 ml propofol and 20 ml propofol bottles (filled to various levels, some opened ... Testimony indicated that propofol, in conjunction with other drugs in Jackson's system, had played the key role in his death. ... While in Jackson's bedroom, she found an empty 20 ml propofol bottle and an empty 5 ml flumazenil bottle on the floor next to ...
Propofol and midazolam are equally effective as sedatives. Hypertonic saline can improve ICP by reducing the amount of cerebral ...
Propofol is believed to work at least partly via a receptor for GABA. Propofol was first synthesized in 1977 and approved for ... Propofol can be run through a peripheral IV or central line. Propofol is frequently paired with fentanyl (for pain relief) in ... "Propofol-Lipuro 1% (propofol) Injectable emulsion for infusion - 1,000 mg in 100 ml (10 mg /ml) : Fact Sheet for health Care ... Propofol is also used in veterinary medicine for anesthesia. To induce general anesthesia, propofol is the drug used almost ...
Propofol extravasation pain masked by lignocaine premedication. Korean Journal of Anesthesiology 74: 366-367, No. 4, Aug 2021. ... Lidocaine/propofol. Extravasation pain masking (first report) and extravasation pain: case report ... Lidocaine/propofol. Reactions Weekly 1887, 420 (2022). https://doi.org/10.1007/s40278-022-08085-y ...
The defense theory is that Jackson self-administered extra drugs and propofol on the last night of his life without Murrays ... Rogers said it just didnt make sense that Jackson awoke from propofol slumber and gave himself another fatal dose during the ... Most important for the states case: Rogers testified it was his conclusion that the cause of death was "acute propofol ... as Jacksons propofol-induced sleep sometimes kept him under for as long as 15 hours at a stretch. ...
The VMD has issued a product defect recall alert for all batches of Propofol Emulsion for Injection 1.0% w/v currently on the ... Product recall - Propofol 24 February 2017. The VMD has issued a product defect recall alert for all batches of Propofol ...
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The American Society of Anesthesiologists commends Missouri Governor Jay Nixon on his decision not to use propofol in a manner ... Propofols wide-spread patient acceptance and tolerance in procedures requiring anesthesia make this medicine critically ...
Bioackumulering. Propofol har låg potential att bioackumuleras.. Toxicitet. Propofol har mycket hög akut toxicitet.. Risk. ... Based on the information that propofol is not readily biodegradable (no other studies are available) the statement "propofol is ... However, ,91% removal of propofol from the aqueous phase was observed, which was noted at the time as being possibly due to ... Propofol anges som lättnedbrytbart. Ändrat T från 3 till 1. Kollat mätrapporter. [Helena Ramström 2018-12-20] Referensgruppens ...
Examining whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly ... Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial. Surg ... For instance, the combination of dexmedetomidine and propofol has been used to reduce propofol doses during endoscopy.6 However ... Low doses of ketamine have the effect of sparing propofol, and it has been shown that propofol-ketamine combination IV ...
Herein, we investigated the role of esketamine in propofol-induced brain injury. A rat model of propofol-induced brain injury ... Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K ... It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the ... The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress ...
Michael Jacksons Toxicology Report Shows Lethal Amount Of Propofol ... But our sources say Propofol was - as one source put it - "front and center in terms of why [Jackson] died." ... sources tell us the toxicology report in the Michael Jackson case shows Jackson had a lethal amount of the anesthetic Propofol ...
... Elizabeth Rebello, MD; Joel Berger, CRNA; Spencer Kee, MD Share ... Of note, both propofol and Diprivan® also contain disodium edetate (0.005%) to retard the rate of growth of microorganisms in ... Condensation was noted on the stopper of vials of propofol and inside the flip top cap which raised concerns about the drugs ... Thus for patient safety, we believe that providers should routinely swab propofol and Diprivan® vials prior to administering ...
Propofol 1% and 2% MCT Fresenius. Propofol 1% and 2% MCT Fresenius - Highly effective short acting hypnotic with an improved ... Over a billion propofol-based anaesthetics performed to date worldwide.1. PONV = Post-operative nausea and vomiting. 1 IMS ...
... to execute a death row inmate next month using for the first time a lethal dose of the widely-used anesthesia drug propofol. ... Propofol made headlines recently for being the drug that claimed the life of Michael Jackson. In clinical practice, propofol is ... The delay could lead to widespread propofol shortages nationwide. Propofol shortages have occurred in the past due to ... Propofol, a widely used anesthetic, could be used in a death row execution scheduled for next month. ignis, CC BY-SA 3.0 *Share ...
propofol answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, ... "Propofol." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Tabers Online, www.tabers.com/tabersonline/view/ ... Tabers-Dictionary/735114/all/propofol. Propofol. In: Venes DD, ed. Tabers Medical Dictionary. F.A. Davis Company; 2021. https ... Propofol [Internet]. In: Venes DD, editors. Tabers Medical Dictionary. F.A. Davis Company; 2021. [cited 2023 December 10]. ...
Propofol Used For Death Penalty. With execution dates set for 2 men on death row in Missouri, the state is on track to be the ... AEG addiction expert says, Michael s drug addiction gave him "a grave prognosis" for a long life and each dose of propofol was ... Sleep expert Doctor Czeisler of Harvard was called to testify for a second day and spoke of the effects of Propofol on ... but he had played Russian Roulette by using Propofol to sleep. ... Propofol. Trending MJ News. * Official Michael Jackson Statue. ...
Propofol should be drawn up immediately before its use and not left standing. Intravenous (IV) infusion lines and stopcock dead ... Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-20141 Andrés Zorrilla-Vaca. , Jimmy J. Arevalo, ... Syringes and needles must never be reused (2). Also, the aseptic technique for administration of propofol includes cleaning of ... Algorithm for helping reduce the likelihood of infectious disease events when using propofol. To avoid intrinsic contamination ...
Health Canada - Summary Safety Review - Propofol Containing Products Health Canada will publish a summary safety review ...
Halothane and propofol appear to cause much less emergence agitation. The aim of this study was to compare the incidence of ... The mean dose during maintenance of anesthesia with propofol was 9.0 mg/kg/h or halothane 1.5-2% and fentanyl at a total dose ... 20.5+/-5.4 minutes, respectively, P,0.01). Conclusions:In children, the administration of propofol maintenance anesthesia is ... The subjects were 83 premedicated children aged 1 to 6 years who underwent surgical procedures with propofol (group P, n=41) or ...
Furthermore, total intravenous anesthesia with propofol resulted in significant cost reductions. ... propofol given for the maintenance of general anesthesia improves the postoperative patient well-being and reduces the ... Conclusion: We observed that when compared with sevoflurane, propofol given for the maintenance of general anesthesia improves ... Comparison of sevoflurane versus propofol under auditory evoked potential monitoring in female patients undergoing breast ...
Propofol infusion syndrome; are high doses always required? Síndrome por infusión de propofol; ¿realmente se requieren altas ... Inicio Revista Española de Anestesiología y Reanimación (English Edition) Propofol infusion syndrome; are high doses always ...
... propofol), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and ... propofol and apomorphine both increase sedation. Use Caution/Monitor.. apomorphine and propofol both increase QTc interval. Use ... propofol and mirtazapine both increase sedation. Use Caution/Monitor.. mirtazapine and propofol both increase QTc interval. Use ... encoded search term (propofol (Diprivan)) and propofol (Diprivan) What to Read Next on Medscape ...
Meaning, does the propofol simply erase the memory of what happened, which might have been painful, or does it also eliminate ... Propofol is something that I had. 4 operations on. I actually wanted. the experience again, even though. 2 were back surgeries ... The only side effect, so far as I could tell, was that feeling of I wish I could have stayed in that pleasant propofol place ... So to answer your question- yes we might actually feel pain but the propofol sucks us I to a sleep where the pain receptor part ...
Simulation of Propofol Administration with a 3-Compartment Pharmacokinetic Model - NOT FOR CLINICAL USE Best viewed with a ... A three-compartment propofol model using pharmacokinetic parameters from Gepts et al, Anesth Analg 66:1256-63, 1987 or Fechner ...
Furthermore, isoflurane did not have a greater impact on the olfactory acuity of dogs compared to propofol (p = 0.669) and no ... The dog was then anesthetized with either propofol or isoflurane and a light plane of anesthesia was maintained on each ... Each dog received two treatments, isoflurane and propofol, in a randomized order with an 11-day washout period between ... This study examined the effects of two commonly used anesthetics, isoflurane (an inhalant agent) and propofol (an injectable ...
... s for propofol. This was equivalent to 0.65 of the ED(50) of propofol. The time to loss of response to pain was 226 (169-300) s ... were randomly allocated to receive either propofol or sevoflurane. The predicted induction dose of propofol, estimated from age ... Propofol. Anaesthesia. Sevoflurane. Inhaled anaesthetics. Obstetric anaesthesia. Molecular mechanisms. Chloroform anaesthesia. ... Loss of volition and pain response during induction of anaesthesia with propofol or sevoflurane by. Thompson S, Drummond GB.. ...
Twenty people who were injected with propofol at a cosmetic surgery clinic in Gangnam, southern Seoul, on Monday were ... 20 patients poisoned by doses of propofol. A vehicle of a forensic team of Seoul police on Tuesday sits in front of a cosmetic ... "We think the propofol may have been tainted," said an employee of the clinic in Gangnam. Police inspected the clinic on Monday ... Propofol is a powerful anesthetic and memory loss agent that can be fatal in large doses. It was the drug that killed Michael ...
Propofol injection pain: Is it still an issue? The effect of premedication. Publication. Publication. Minerva Anestesiologica: ... Dedic, A, Adam, S, Gommers, D.A.M.P.J, & van Bommel, J. (2010). Propofol injection pain: Is it still an issue? The effect of ... In both groups a mixture of 40 mL propofol 1% with 2 mL lidocaine 1% was used to induce anesthesia. Pain scores were assessed ... Background. The use of propofol often results in pain upon injection. Various strategies can be used to reduce this pain, ...
... of propofol infusion for 90 minutes. Rectal temperature, heart rate, respiratory rate, pedal reflex, echocardiogram, propofol ... In the adult dog, the combination medetomidine 30 ug/kg and propofol 0.2 mg/kg/min was known to provide a sufficient surgical ... Propofol concentrations were increased in dose-dependent manner, and were significantly increased after 30 minutes in P0.6 and ... In puppies, infusion with 0.6 or 0.8 mg/kg/min of propofol produced a surgical anaesthesia. However, their application should ...
2.5 µg/ml propofol (Sigma-Aldrich; Merck KGaA) group; iii) 5 µg/ml propofol group; and iv) 10 µg/ml propofol group, which were ... Propofol, Propofol + pcDNA, and Propofol + circ-PVT1) were designed. As presented in Fig. 6A and B, downregulation of ETS1 ... Propofol is frequently used for anesthesia in cancer surgery. It has been suggested that treatment with propofol serves a tumor ... Propofol is a commonly used anesthetic in the clinic (1). Previous studies have investigated the inhibitory effect of propofol ...
... a high profile case such as the death of Michael Jackson to bring worldwide attention to the misuse and dangers of Propofol. ... So what is propofol?. Propofol is a short-acting sedative-hypnotic agent. It has become one of the most widely used anesthetic ... Securing Propofol, June 2009. *ASA Supports DEA Proposal to Schedule Propofol, American Society of Anesthesiologists, November ... Propofol has become a popular recreational drug among medical professionals. Subanesthetic levels of propofol have been ...
  • Murray's most grievous act, according to the prosecution, was that he dared to bring the hospital-only anesthetic propofol into a private home and use it without the proper monitoring and resuscitation equipment. (thedailybeast.com)
  • The American Society of Anesthesiologists commends Missouri Governor Jay Nixon on his decision not to use propofol in a manner that may have significantly affected the availability of this medication for the anesthetic care of patients in America. (asahq.org)
  • As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. (degruyter.com)
  • Propofol (2,6-diisopropylphenol) is an intravenous anesthetic widely used in surgery or intensive care units to induce and maintain anesthesia as well as sedation [ 2 ]. (degruyter.com)
  • Multiple law enforcement sources tell us the toxicology report in the Michael Jackson case shows Jackson had a lethal amount of the anesthetic Propofol in his system - but that wasn't the only drug. (newsone.com)
  • Propofol, a widely used anesthetic, could be used in a death row execution scheduled for next month. (medicaldaily.com)
  • The dog was then anesthetized with either propofol or isoflurane and a light plane of anesthesia was maintained on each respective anesthetic for 30 minutes. (purdue.edu)
  • Propofol is a powerful anesthetic and memory loss agent that can be fatal in large doses. (joins.com)
  • However, the little data are available concerning anesthetic effects in puppies treated with medetomidine and propofol. (vin.com)
  • Propofol is a commonly used anesthetic in the clinic ( 1 ). (spandidos-publications.com)
  • Propofol has become a popular anesthetic because its relatively 'short action' allows for a quick recovery, and is considered safe with minimal side effects. (healthworldnet.com)
  • We conclude that continuous infusion of propofol on these studied rates does not promote significant alterations in the electrocardiogram, and both anesthetic protocols analyzed could be safe methods to be used in patients with some cardiac damage. (vin.com)
  • Unfortunately, because propofol is labeled an anesthetic, GI docs in most hospital endoscopy units are blocked from using the drug by the hospitals' anesthesia departments, which set sedation policies. (jwatch.org)
  • Prior studies have suggested that propofol (2, 6-diisopropylphenol), one of the most extensively used intravenous anesthetic agents during cancer surgical excision, influences the biological behaviors of cancer cell, including growth, invasiveness, and metastasis [ 10 , 11 ]. (aging-us.com)
  • It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS. (researchsquare.com)
  • Propofol, a widely used intravenous anesthetic agents, has been reported to have anti-inflammation effects. (researchsquare.com)
  • Propofol is a short and rapid-acting general anesthetic with narcotic and sedative properties. (biesterfeld.com)
  • A lethal dose of propofol is used for medical assistance in dying in Canada to quickly induce deep coma and death, but rocuronium is always given-even when the patient dies as a result of propofol injection. (wikipedia.org)
  • and on his left leg, there is another bruise from the permanent intravenous port Murray had installed behind his knee to facilitate his nightly dose of propofol. (thedailybeast.com)
  • Rogers said it just didn't make sense that Jackson awoke from propofol slumber and gave himself another fatal dose during the two minutes that Murray claimed he was out of the room. (thedailybeast.com)
  • We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. (dovepress.com)
  • IV lidocaine reduced the total and maintenance propofol dose in Group L ( p (dovepress.com)
  • AEG addiction expert says, Michael 's drug addiction gave him "a grave prognosis" for a long life and each dose of propofol was like playing "Russian roulette! (mjworld.net)
  • The mean dose during maintenance of anesthesia with propofol was 9.0 mg/kg/h or halothane 1.5-2% and fentanyl at a total dose of 5 microg/kg administered during surgery. (medscimonit.com)
  • The predicted induction dose of propofol, estimated from age and weight for each patient, was given at a rate of 1% of the induction dose per second, to a possible maximum of 2.5 times the predicted induction dose. (general-anaesthesia.com)
  • Propofol concentrations were increased in dose-dependent manner, and were significantly increased after 30 minutes in P0.6 and P0.8. (vin.com)
  • It was identified that propofol inhibited the viability and invasion, but promoted apoptosis of HGC‑27 and AGS cells in a dose‑dependent manner. (spandidos-publications.com)
  • The aim of this work was to evaluate fortuitous electrocardiographic alterations in dogs, promoted by increasing dose of propofol administrated by continuous infusion, associated or not to nitrous oxide. (vin.com)
  • Subsequently, propofol clinical data from three dose levels in intact patients and anhepatic subjects were used for the optimization of hepatic and renal CL int in a simultaneous fitting routine. (aspetjournals.org)
  • Both propofol and dexmedetomidine decrease systemic blood pressure, heart rate, and cardiac output in a dose-dependent manner. (biomedcentral.com)
  • In the first group ( n = 42), sedation was performed by intravenous propofol infusion at a dose of 4 to 12 mg/kg/hour. (biomedcentral.com)
  • A person could have no reaction to a large dose of propofol and another person could have a profound reaction a small dose of propofol. (drug-alcohol.com)
  • Sedation is frequently necessary in patients with septic shock, and therefore Zausig and colleagues investigated the effects of dose-dependent effects of various induction agents (propofol, midazolam, s(+)-ketamine, methohexitone, etomidate) in a Langendorff heart preparation from rats rendered septic by CLP. (resus.me)
  • I recently came across an article by Dr Rick Pescatore in Emergency Medicine News [ 1 ] related to the use of low-dose propofol to treat headache in the ED. It immediately caught my attention because treating migraine and other types of headache is a common part of emergency medicine practice. (medscape.com)
  • The ABM-based propofol induction dose has a high success rate in normal, overweight and obese patients . (bvsalud.org)
  • Propofol, marketed as Diprivan, among other names, also known as 2,6-diisopropylphenol, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. (wikipedia.org)
  • Fass miljöinformation för Diprivan (propofol) från Aspen Nordic (hämtad 2024-01-19). (janusinfo.se)
  • Arkivdokumentation från Fass Diprivan (propofol) finns från 2011-05-24. (janusinfo.se)
  • 1 The package inserts for both propofol and Diprivan ® recommend that strict aseptic techniques be used in preparing and administering the agents and that vials be disinfected with 70% isopropyl alcohol prior to administration. (apsf.org)
  • 4 The recommendation to swab the vials of propofol and Diprivan ® may be due to its formulation in a white, oil-in-water emulsion. (apsf.org)
  • Of note, both propofol and Diprivan ® also contain disodium edetate (0.005%) to retard the rate of growth of microorganisms in the event of accidental extrinsic contamination. (apsf.org)
  • Thus for patient safety, we believe that providers should routinely swab propofol and Diprivan ® vials prior to administering these agents and be aware of another drug that may look similar. (apsf.org)
  • Propofol also known as Diprivan is a short-acting intravenous drug that is used for general anesthesia. (drug-alcohol.com)
  • One of the reasons propofol is thought to be more effective (although it has a longer half-life than lorazepam) is because studies have found that benzodiazepines like midazolam and lorazepam tend to accumulate in critically ill patients, prolonging sedation. (wikipedia.org)
  • Because of its rapid induction and recovery time, propofol is also widely used for sedation of infants and children undergoing MRI. (wikipedia.org)
  • In March 2021, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for Propofol‐Lipuro 1% to maintain sedation via continuous infusion in people older than sixteen with suspected or confirmed COVID-19 who require mechanical ventilation in an intensive care unit ICU setting. (wikipedia.org)
  • Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. (dovepress.com)
  • Propofol is a remarkable drug that has revolutionized sedation for patients undergoing endoscopic procedures. (jwatch.org)
  • Because it has proven to be more effective than hypnotics (such as versed) and narcotics (such as fentanyl), an estimated 40% of all endoscopic sedation in the U.S. is now being performed with propofol. (jwatch.org)
  • You are setting up for procedural sedation and would like to use propofol. (sinaiem.org)
  • Propofol is indicated for the induction and maintenance of general anesthesia or sedation in children and adults during surgical or other diagnostic procedures. (npra.gov.my)
  • The use of propofol is most commonly seen in the sedation of mechanically ventilated adults and sedation during surgery. (drug-alcohol.com)
  • Furthermore, total intravenous anesthesia with propofol resulted in significant cost reductions. (nih.gov)
  • Also, the aseptic technique for administration of propofol includes cleaning of the rubber bung, if present, with isopropyl alcohol, leaving it to dry. (cdc.gov)
  • In children, the administration of propofol maintenance anesthesia is associated with a significantly higher incidence of emergence agitation than halothane maintenance anesthesia. (medscimonit.com)
  • There are reports of self-administration of propofol for recreational purposes. (blogs.com)
  • The aim of this study was to compare the incidence of emergence agitation in children receiving either propofol or halothane anesthesia for a variety of surgical treatments using the Pediatric Anesthesia Emergence Delirium (PAED) scale. (medscimonit.com)
  • Thirty-eight female patients (age 39 (9) yr, weight 65 (11) kg, and height 165 (8) cm) (mean (SD)) were randomly allocated to receive either propofol or sevoflurane. (general-anaesthesia.com)
  • Patients aged 65-90 yr undergoing major cancer surgery were randomised to either propofol -based anaesthesia or to sevoflurane -based anaesthesia. (bvsalud.org)
  • In conclusion, the present study indicated that propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ‑PVT1/miR‑195‑5p/ETS1 axis. (spandidos-publications.com)
  • Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
  • Step 2: Lidocaine 40 mg given as 4ml of 1% preparation to reduce the burning sensation and pain associated with the injection of propofol. (wikipedia.org)
  • Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. (dovepress.com)
  • IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction. (dovepress.com)
  • In both groups a mixture of 40 mL propofol 1% with 2 mL lidocaine 1% was used to induce anesthesia. (eur.nl)
  • In contrast, only 11 of the patients given propofol lost the response to pain after 2.5xED(50) had been given. (general-anaesthesia.com)
  • Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. (bvsalud.org)
  • The VMD has issued a product defect recall alert for all batches of Propofol Emulsion for Injection 1.0% w/v currently on the market, produced by Norbrook Laboratories (Inductofol, Vetofol and Norofol). (bsava.com)
  • Propofol emulsion for injection or infusion local package insert [Internet]. (npra.gov.my)
  • Previous studies have investigated the inhibitory effect of propofol on cancer cells in a variety of tumors, such as breast ( 2 ), lung ( 3 ) pancreatic ( 4 ), ovarian ( 5 ), hepatic ( 6 ) and gastric cancer (GC) ( 7 , 8 ). (spandidos-publications.com)
  • Background: The lung protecting effect of propofol requires methods to measure the propofol concentration of the epithelial line fluid covering the alveolar surface.We hypothesized that (1) propofol can be determined in bronchoalveolar lavage (BAL) by reversed phase high performance liquid chromatography with fluorescence detection. (uni-luebeck.de)
  • Another recent but rare side effect of propofol use is propofol infusion syndrome. (drug-alcohol.com)
  • There was an association between lack of control of propofol (e.g., pharmacy accounting) at the time of abuse and incidence of abuse at the program. (healthworldnet.com)
  • W e compared the time to reach two anaesthetic end-points during induction of anaesthesia with a potent inhalation agent (sevoflurane) and an i.v. agent (propofol). (general-anaesthesia.com)
  • After medetomidine premedication (30ug/kg) and propofol induction (2 mg/kg), dogs were maintained with 0.2 mg/kg/min (P0.2), 0.4 mg/kg/min (P0.4), 0.6 mg/kg/min (P0.6), and 0.8 mg/kg/min (P0.8) of propofol infusion for 90 minutes. (vin.com)
  • We compared the postoperative nausea and vomiting of propofol-based total intravenous anesthesia (TIVA) and sevoflurane (SEVO) anesthesia under auditory evoked potential (AEP) monitoring in female patients undergoing breast surgery. (nih.gov)
  • We observed that when compared with sevoflurane, propofol given for the maintenance of general anesthesia improves the postoperative patient well-being and reduces the incidence of PONV. (nih.gov)
  • The median times and interquartile values for loss of arm tone were 105 (88-121) s for sevoflurane and 65 (58-80) s for propofol. (general-anaesthesia.com)
  • It was also demonstrated that propofol inhibited sevoflurane-induced inflammation through NF-κB pathway in human neuroglioma cells [ 15 ]. (researchsquare.com)
  • We therefore tested the primary hypothesis that there is less delirium after propofol -based than after sevoflurane -based anaesthesia within 7 days of major cancer surgery . (bvsalud.org)
  • To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. (wikipedia.org)
  • According to its package insert however, as approved by the U.S. FDA, propofol is only supposed to be administered by healthcare professionals trained in the administration of general anesthesia, such as anesthesiologists and certified registered nurse anesthetists (CRNA). (healthworldnet.com)
  • While propofol use is common when used in general anesthesia it has also become more common for recreational purposes. (drug-alcohol.com)
  • Propofol use would probably be more common recreationally if it was more available to the general public but seeing how it is mainly used for general anesthesia you can't get it in a prescription at home. (drug-alcohol.com)
  • Propofol is also used in veterinary medicine for anesthesia. (wikipedia.org)
  • Propofol use is also common in veterinary medicine. (drug-alcohol.com)
  • In puppies, infusion with 0.6 or 0.8 mg/kg/min of propofol produced a surgical anaesthesia. (vin.com)
  • 3) Wiskin AE, Smith J, Wan SKY, Nally MWJ, Shah N. "Propofol anaesthesia is safe in children with food allergy and undergoing endoscopy. (sinaiem.org)
  • Delirium is a common and disturbing postoperative complication that might be ameliorated by propofol -based anaesthesia. (bvsalud.org)
  • We aimed to determine the success rate of inducing anaesthesia in normal, overweight and obese patients with propofol , using an adjusted body mass scalar (ABM), which embodies the increased FFM of obese patients . (bvsalud.org)
  • Materials and Methods: The suppression effects of propofol on the proliferation and invasion of cervical cancer cells were analyzed by Cell Counting Kit-8 (CCK-8), colony formation and Transwell invasion assay. (aging-us.com)
  • Subanesthetic levels of propofol have been described to induce a "high" that is characterized by euphoria and sensitization. (healthworldnet.com)
  • RePub, Erasmus University Repository: Propofol injection pain: Is it still an issue? (eur.nl)
  • Propofol injection pain: Is it still an issue? (eur.nl)
  • The use of propofol often results in pain upon injection. (eur.nl)
  • However, basic premedication protocol aimed at peri- and postoperative pain reduction could also sufficiently reduce propofol injection pain, rendering other special interventions redundant. (eur.nl)
  • Some of the risks associated with propofol use aside from low blood pressure are apnea and pain in the injection site. (drug-alcohol.com)
  • Most important for the state's case: Rogers testified it was his conclusion that the cause of death was "acute propofol intoxication" exacerbated by two sedatives given by Murray-lorazepam and midazolam-and that the manner of death was homicide. (thedailybeast.com)
  • Propofol extravasation pain masked by lignocaine premedication. (springer.com)
  • Propofol Injectable Emulsion, USP Condensation. (apsf.org)
  • Propofol Injectable Emulsion, USP. (apsf.org)
  • Propofol is an injectable emulsion containing water, egg lecithin, soybean oil and glycerin. (sinaiem.org)
  • Propofol Injectable Emulsion Safety Data Sheet. (sinaiem.org)
  • Du X , Wang X , Zheng Y , Liu D , . Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG. (aging-us.com)
  • In critically ill patients, propofol is superior to lorazepam both in effectiveness and overall cost. (wikipedia.org)
  • Propofol infusion syndrome is potentially lethal and has been reported in critically ill patients after they have used high-doses of it in combination with corticosteroids and catecholamines. (drug-alcohol.com)
  • Of course we should be cautious about extrapolating animal lab work to clinical practice, but this supports my position of vehement opposition to the injudicious use of propofol for RSI in critically ill patients! (resus.me)
  • Can you review the basic pharmacology of propofol? (medscape.com)
  • Användningen av propofol (försäljningsdata Sverige 2021) har bedömts medföra låg risk för miljöpåverkan. (janusinfo.se)
  • 2021. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/735114/all/propofol. (tabers.com)
  • This study examined the effects of two commonly used anesthetics, isoflurane (an inhalant agent) and propofol (an injectable agent), on canine olfactory-cognitive circuitry in detecting brown root rot fungus (BRR). (purdue.edu)
  • Each dog received two treatments, isoflurane and propofol, in a randomized order with an 11-day washout period between treatments. (purdue.edu)
  • Furthermore, isoflurane did not have a greater impact on the olfactory acuity of dogs compared to propofol (p = 0.669) and no significant difference in the overall effect between the two anesthetics (p = 0.278). (purdue.edu)
  • We concluded that isoflurane and propofol do not cause negative effect on canine olfaction within 24 hours. (purdue.edu)
  • Propofol has GABA potentiation, which probably provides a certain amount of direct analgesia. (medscape.com)
  • In colorectal cancer, propofol inhibits cancer cells proliferation and metastasis by regulating miR-124-3p.1/AKT3 [ 13 ]. (aging-us.com)
  • Condensation was noted on the stopper of vials of propofol and inside the flip top cap which raised concerns about the drug's potential sterility (Figures 1 and 2). (apsf.org)
  • But the clinical use of propofol has significantly increased that incidence of dependence several fold. (healthworldnet.com)
  • Results: TNF-α (10 ng/ml, 4 h) significantly decreased the expression of occludin, which was attenuated by propofol (25 μM). (researchsquare.com)
  • Propofol is also referred to as "milk of amnesia" which is a play on the words "milk of magnesia" because it has a milky white consistency when it is prepared for intravenous use. (drug-alcohol.com)
  • propofol will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. (medscape.com)
  • A physiologically based pharmacokinetic (PBPK) modeling approach was used to assess the prediction accuracy of propofol hepatic and extrahepatic metabolic clearance and to address previously reported underprediction of in vivo clearance based on static in vitro-in vivo extrapolation methods. (aspetjournals.org)
  • Incidence of death among propofol users was 28%, many of whom were residents. (healthworldnet.com)
  • This study was performed to evaluate anaesthetic effects of variable infusion rates of propofol in beagle puppies premedicated with medetomidine. (vin.com)
  • Propofol has gradually become the most common sedative-hypnotic drug used in painless gastroscopy due to its rapid effect, short half-life, and good sedative effect, but it has disadvantages such as a weak analgesic effect and suppression of respiratory and circulatory systems. (dovepress.com)
  • Propofol is a short-acting sedative-hypnotic agent. (healthworldnet.com)
  • Several guidelines recommend the use of propofol for the treatment of refractory status epilepticus. (wikipedia.org)
  • The predictive capacity of propofol intrinsic clearance data (CL int ) obtained in human hepatocytes and liver and kidney microsomes was assessed using the PBPK model developed in MATLAB software. (aspetjournals.org)
  • With execution dates set for 2 men on death row in Missouri, the state is on track to be the first to use the drug Propofol for administering the death penalty. (mjworld.net)
  • Doing some Googling on propofol before writing this post, I learned this sort of reaction is why the drug is illicitly used non-medically. (blogs.com)
  • Propofol is a prescription drug and is not available over-the-counter. (healthworldnet.com)
  • Propofol is not a controlled or 'schedule' drug, unlike many sedatives. (healthworldnet.com)
  • Propofol has become a popular recreational drug among medical professionals. (healthworldnet.com)
  • Given the restrictions on propofol use, many endoscopists have resorted to calling in anesthesiologists or anesthetists to administer the drug in routine cases. (jwatch.org)
  • There is a wide range of different reactions to the drug propofol so the potential misuse of it can be common and at least three deaths from self-administration have been recorded from propofol use. (drug-alcohol.com)
  • Comprehensive documentation for drug registration of Propofol can be provided by Biesterfeld as referred. (biesterfeld.com)
  • Propofol is a safe drug. (medscape.com)
  • Step 3: Propofol 1000 mg given as 100ml of 10 mg/ml preparation. (wikipedia.org)
  • The defense theory is that Jackson self-administered extra drugs and propofol on the last night of his life without Murray's knowledge and caused his own death. (thedailybeast.com)
  • Propofol can be self-administered for short-term effects such as mild euphoria, hallucinations, and lack of inhibition. (drug-alcohol.com)
  • Recreational propofol use is most commonly found among medical staff such as anesthesiologists who have access to it. (drug-alcohol.com)
  • The subjects were 83 premedicated children aged 1 to 6 years who underwent surgical procedures with propofol (group P, n=41) or with halothane (group H, n=42) anesthesia. (medscimonit.com)
  • In the adult dog, the combination medetomidine 30 ug/kg and propofol 0.2 mg/kg/min was known to provide a sufficient surgical anesthesia. (vin.com)
  • We are aware of the controversy that Dr. Gold's report of trace levels of fentanyl and propofol in the air of surgical rooms has evoked. (cdc.gov)
  • Propofol is frequently paired with fentanyl (for pain relief) in intubated and sedated people. (wikipedia.org)
  • Propofol abuse is on the rise but pales in comparison to other medications such as opioids and fentanyl. (healthworldnet.com)
  • It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. (degruyter.com)
  • The effects caused by propofol were attenuated by esketamine. (degruyter.com)
  • Therefore, a better understanding of the mechanism underlying propofol-induced neurotoxicity is favorable for eliminating the side effects of propofol. (degruyter.com)
  • Sleep expert Doctor Czeisler of Harvard was called to testify for a second day and spoke of the effects of Propofol on Michael's brain, nervous system and body. (mjworld.net)
  • These previous studies have mostly been limited to the pharmacodynamic effects of propofol on phenotypes, and the underlying mechanisms of the antitumor effects still need to be explored. (spandidos-publications.com)
  • Herein, we tried to address the potential anti-cancer effects of propofol in cervical carcinoma. (aging-us.com)
  • In this study, we investigated the effects of TNF-α and propofol on occludin expression in human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), and explored the underlying mechanisms. (researchsquare.com)
  • Not only that but propofol use has strong adverse side effects when mixed with benzodiazepines which is the concoction the coroner said killed Michael Jackson. (drug-alcohol.com)
  • Propofol exerted the most pronounced depressant effects on both the maximal systolic contraction and the minimal diastolic relaxation, and cardiac work. (resus.me)
  • Effects of prenatal propofol exposure on postnatal development in rats. (bvsalud.org)
  • 1) One retrospective analysis of propofol being used in 76 procedures in 55 patients with egg, soy or nut allergy revealed 13 adverse events, but none due to propofol. (sinaiem.org)
  • 2) In another study of propofol being used for 28 children with egg allergy, only one child had an [non-anaphylactic] allergic reaction. (sinaiem.org)
  • The University of Colorado survey revealed that "there was no established system to control or monitor propofol as is done with opioids at 71% of programs. (healthworldnet.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
  • Furthermore, reintroduction of MIR155HG into cervical cancer cells counteracted the inhibitory potency of propofol on the growth and aggressive phenotypes in cervical carcinoma cells. (aging-us.com)
  • has been issued for registration holders of propofol products to update the local package inserts to reflect this safety information. (npra.gov.my)
  • Concomitantly, continuous infusion of propofol (0.4mg/kg/min) was initiated using an infusion pump. (vin.com)
  • The King of Pop had apparently been using propofol and toxicology reports found significant amounts of propofol along with other drugs. (healthworldnet.com)
  • So, why is propofol become one of the illicit prescription drugs of choice for both medical professionals and celebrities? (healthworldnet.com)
  • To date, the NPRA has received a total of 77 reports with 128 adverse events suspected to be related to propofol containing products. (npra.gov.my)
  • Report all suspected adverse events associated with the use of propofol products to the NPRA. (npra.gov.my)
  • In vitro , propofol inhibited the growth and colony-formation of cervical carcinoma cells. (aging-us.com)
  • In the present study, GC cell lines (HGC‑27 and AGS) were treated with various concentrations of propofol, and an MTT assay was performed to detect the cell viability. (spandidos-publications.com)