A class of organic compounds known as STEROLS or STEROIDS derived from plants.
Stigmasterol is a plant-derived steroidal sapogenin, structurally similar to cholesterol, found in various plants and some animal sources, which exhibits weak estrogenic activity and has potential uses in the pharmaceutical industry.
A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography.
A plant genus of the family Aloeaceae, order Liliales (or Asphodelaceae, Asparagales in APG system) which is used medicinally. It contains anthraquinone glycosides such as aloin-emodin or aloe-emodin (EMODIN).
Oil from ZEA MAYS or corn plant.
Oils derived from plants or plant products.
A plant genus of the family ASTERACEAE that is similar to CONYZA. Members contain SESQUITERPENES.
A CHROMATOGRAPHY method using supercritical fluid, usually carbon dioxide under very high pressure (around 73 atmospheres or 1070 psi at room temperature) as the mobile phase. Other solvents are sometimes added as modifiers. This is used both for analytical (SFC) and extraction (SFE) purposes.
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
'Squalene' is a biologically occurring triterpene compound, naturally produced in humans, animals, and plants, that forms an essential part of the lipid-rich membranes in various tissues, including the skin surface and the liver, and has been studied for its potential benefits in skincare, dietary supplements, and vaccine adjuvant systems.
Substances used to lower plasma CHOLESTEROL levels.
Azetidines are saturated, organic compounds containing a 4-membered ring with two carbon atoms and two nitrogen atoms (one as a secondary amine), which can be found in certain pharmaceuticals and natural substances, although they are less common than other cyclic amines.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Cholesterol present in food, especially in animal products.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Regular course of eating and drinking adopted by a person or animal.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.
Fatty acids which are unsaturated in only one position.
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.

Post-ingestive feedbacks and associative learning regulate the intake of unsuitable sterols in a generalist grasshopper. (1/487)

Behavioural studies of the grasshopper Schistocerca americana were undertaken to identify the mechanisms that regulate the intake of dietary sterols. In the first experiment, grasshoppers were allowed to feed on spinach, a plant containing only unsuitable sterols; immediately after this first meal, a suitable or unsuitable sterol was injected into the haemolymph. Grasshoppers injected with unsuitable sterols had second meals on spinach that were significantly shorter than those of grasshoppers injected with suitable sterols, indicating that unsuitable dietary sterols are detected post-ingestively. In the second experiment, grasshoppers were fed food containing only unsuitable sterols and were then presented with glass-fibre discs containing different concentrations of a suitable sterol or sucrose only (the control). The results suggest that grasshoppers do not use a direct feedback operating on mouthpart chemoreceptors to regulate their intake of suitable sterols. In the third experiment, grasshoppers were presented with artificial diets containing different sterols and flavours, and feeding was observed over a sequence of meals. The results from both the first and last experiments suggest a role for associative learning in regulating the intake of unsuitable sterols.  (+info)

The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. (2/487)

Since the isolation and characterization of dwarf1-1 (dwf1-1) from a T-DNA insertion mutant population, phenotypically similar mutants, including deetiolated2 (det2), constitutive photomorphogenesis and dwarfism (cpd), brassinosteroid insensitive1 (bri1), and dwf4, have been reported to be defective in either the biosynthesis or the perception of brassinosteroids. We present further characterization of dwf1-1 and additional dwf1 alleles. Feeding tests with brassinosteroid-biosynthetic intermediates revealed that dwf1 can be rescued by 22alpha-hydroxycampesterol and downstream intermediates in the brassinosteroid pathway. Analysis of the endogenous levels of brassinosteroid intermediates showed that 24-methylenecholesterol in dwf1 accumulates to 12 times the level of the wild type, whereas the level of campesterol is greatly diminished, indicating that the defective step is in C-24 reduction. Furthermore, the deduced amino acid sequence of DWF1 shows significant similarity to a flavin adenine dinucleotide-binding domain conserved in various oxidoreductases, suggesting an enzymatic role for DWF1. In support of this, 7 of 10 dwf1 mutations directly affected the flavin adenine dinucleotide-binding domain. Our molecular characterization of dwf1 alleles, together with our biochemical data, suggest that the biosynthetic defect in dwf1 results in reduced synthesis of bioactive brassinosteroids, causing dwarfism.  (+info)

Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action. (3/487)

BACKGROUND: The effects of probucol and a phytosterol mixture (FCP-3PI) on atherosclerotic lesion formation, plasma lipoproteins, hepatic and lipoprotein lipase activities, antioxidant enzyme activities, and plasma fibrinogen were investigated in apolipoprotein E-knockout (apoE-KO) mice. METHODS AND RESULTS: Three groups of 8 mice were fed a diet containing 9% (wt/wt) fat (controls) or the foregoing diet supplemented with either 1% (wt/wt) probucol (the probucol group) or 2% (wt/wt) FCP-3PI (the FCP-3PI group) for 20 weeks. Compared with controls, atherosclerotic lesion size was 3 times greater in the probucol group, whereas it was decreased by half in the FCP-3PI group. Probucol treatment resulted in high plasma probucol concentrations, which correlated (r=0.69) with the lesion area. HDL cholesterol was reduced (>75%) in the probucol group and slightly increased (14%) in the FCP-3PI-treated group. Postheparin lipoprotein lipase (LPL) activity was significantly reduced in both treatment groups, but only FCP-3PI significantly decreased hepatic lipase activity. Plasma fibrinogen was increased 42% by probucol and decreased 19% by FCP-3PI relative to controls. Probucol significantly increased plasma glutathione reductase, glutathione peroxidase, and superoxide dismutase activities (P<0.05). In contrast to findings in apoE-KO mice, there was no probucol-induced atherosclerosis in their wild-type counterparts fed the same dose for the same period of time. CONCLUSIONS: Antiatherogenic activity of FCP-3PI in apoE-KO mice is associated with an increase in HDL cholesterol concentration along with decreases in hepatic lipase activity and plasma fibrinogen concentrations. Proatherogenic effects of probucol may be related to increased plasma fibrinogen, decreased HDL cholesterol concentrations along with decreased LPL activity, or its direct "toxicity" due to very high plasma concentration. Our studies demonstrate that the antioxidant and cholesterol-lowering properties of probucol do not prevent atherogenesis in this particular animal model.  (+info)

Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. (4/487)

We investigated the changes of cholesterol and non-cholesterol sterol metabolism during plant stanol ester margarine feeding in 153 hypercholesterolemic subjects. Rapeseed oil (canola oil) margarine without (n = 51) and with (n = 102) stanol (2 or 3 g/day) ester was used for 1 year. Serum sterols were analyzed with gas-liquid chromatography. The latter showed a small increase in sitostanol peak during stanol ester margarine eating. Cholestanol, campesterol, and sitosterol proportions to cholesterol were significantly reduced by 5-39% (P < 0.05 or less for all) by stanol esters; the higher their baseline proportions the higher were their reductions. The precursor sterol proportions were significantly increased by 10- 46%, and their high baseline levels predicted low reduction of serum cholesterol. The decrease of the scheduled stanol dose from 3 to 2 g/day after 6-month feeding increased serum cholesterol by 5% (P < 0. 001) and serum plant sterol proportions by 8-13% (P < 0.001), but had no consistent effect on precursor sterols. In twelve subjects, the 12-month level of LDL cholesterol exceeded that of baseline; the non-cholesterol sterol proportions suggested that stimulated synthesis with relatively weak absorption inhibition contributed to the non-responsiveness of these subjects. In conclusion, plant stanol ester feeding lowers serum cholesterol in about 88% of subjects, decreases the non-cholesterol sterols that reflect cholesterol absorption, increases the sterols that reflect cholesterol synthesis, but also slightly increases serum plant stanols. Low synthesis and high absorption efficiency of cholesterol results in the greatest benefit from stanol ester consumption.  (+info)

Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. (5/487)

BACKGROUND: Dietary plant sterols (phytosterols) have been shown to lower plasma lipid concentrations in animals and humans. However, the effect of phytosterol intake from tall oil on cholesterol and phytosterol metabolism has not been assessed in subjects fed precisely controlled diets. OBJECTIVE: Our objective was to examine the effects of sitostanol-containing phytosterols on plasma lipid and phytosterol concentrations and de novo cholesterol synthesis rate in the context of a controlled diet. DESIGN: Thirty-two hypercholesterolemic men were fed either a diet of prepared foods alone or a diet containing 1.7 g phytosterols/d for 30 d in a parallel study design. RESULTS: No overall effects of diet on total cholesterol concentrations were observed, although concentrations were lower with the phytosterol-enriched than with the control diet on day 30 (P < 0.05). LDL-cholesterol concentrations on day 30 had decreased by 8.9% (P < 0.01) and 24.4% (P < 0.001) with the control and phytosterol-enriched diets, respectively. HDL-cholesterol and triacylglycerol concentrations did not change significantly. Moreover, changes in circulating campesterol and beta-sitosterol concentrations were not significantly different between phytosterol-fed and control subjects. In addition, there were no significant differences in fractional (0.091 +/- 0.028 and 0.091 +/- 0.026 pool/d, respectively) or absolute (0.61 +/- 0.24 and 0.65 +/- 0.23 g/d, respectively) synthesis rates of cholesterol observed between control and phytosterol-fed subjects. CONCLUSION: Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men.  (+info)

Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. (6/487)

Previously, we have shown that the Arabidopsis det2 (deetiolated2) mutant is defective in the biosynthesis of brassinosteroids (BR) and that DET2 (a steroid 5alpha-reductase) acts early in the proposed BR biosynthetic pathway. In this paper we present further biochemical characterization of det2. We have undertaken metabolic experiments with 2H-labeled substrates of intermediates involved in the formation of campestanol from campesterol, and quantitative analysis of intermediates in Arabidopsis wild type and det2. The results of these studies indicate the early operating steps of BR biosynthesis as: campesterol --> 4-en-3beta-ol --> 4-en-3-one --> 3-one --> campestanol in Arabidopsis, with det2 deficient in the conversion of 4-en-3-one to 3-one. We have also detected these intermediates in the formation of campestanol from campesterol and their metabolic conversions using cultured cells of Catharanthus roseus. These studies confirmed the biosynthetic sequence of events from campesterol to campestanol as was found in Arabidopsis. As such, the originally proposed biosynthetic pathway should be modified.  (+info)

Hepatitis C: epidemiology and review of complementary/alternative medicine treatments. (7/487)

Hepatitis C is emerging as a serious worldwide problem. In the United States the current mortality figures may triple in the next ten years, rivaling HIV. The disease has a latency of 10-30 years and symptoms or signs may not appear until cirrhosis is evident. Adequate diagnosis, including liver biopsy, is essential in assessing the current stage of the viral infection and the need for treatment. Hepatitis C may manifest as hepatic fibrosis, cirrhosis, hepatocellular carcinoma, lichen planus, glomerulonephritis, mixed cryoglobulinemia, or porphyria. The hepatic damage is due both to the cytopathic effect of the virus and the inflammatory changes secondary to immune activation. The use of the botanical components glycyrrhizin, catechin, silymarin and phytosterols, and the antioxidants N-acetylcysteine and vitamin E are reviewed for their efficacy in treating chronic hepatitis and affecting liver damage.  (+info)

The cholesterol-lowering action of plant stanol esters. (8/487)

Plant sterols and stanols derived from wood pulp and vegetable oils lower total and LDL cholesterol by inhibiting cholesterol absorption from the intestine in humans. Plant stanols are virtually unabsorbable, which makes them more ideal hypocholesterolemic agents than plant sterols. The esterification of plant stanols has allowed their incorporation into various foods such as margarine without changing the taste and texture of those foods. Plant stanol esters at a level of 2-3 g/d have been shown to reduce LDL cholesterol by 10-15% without side effects. Plant stanol esters appear to be a helpful dietary adjunct to a prudent diet to lower cholesterol.  (+info)

Phytosterols are a type of plant-derived sterol that have a similar structure to cholesterol, a compound found in animal products. They are found in small quantities in many fruits, vegetables, nuts, seeds, legumes, and vegetable oils. Phytosterols are known to help lower cholesterol levels by reducing the absorption of dietary cholesterol in the digestive system.

In medical terms, phytosterols are often referred to as "plant sterols" or "phytostanols." They have been shown to have a modest but significant impact on lowering LDL (or "bad") cholesterol levels when consumed in sufficient quantities, typically in the range of 2-3 grams per day. As a result, foods fortified with phytosterols are sometimes recommended as part of a heart-healthy diet for individuals with high cholesterol or a family history of cardiovascular disease.

It's worth noting that while phytosterols have been shown to be safe and effective in reducing cholesterol levels, they should not be used as a substitute for other lifestyle changes such as regular exercise, smoking cessation, and weight management. Additionally, individuals with sitosterolemia, a rare genetic disorder characterized by an abnormal accumulation of plant sterols in the body, should avoid consuming foods fortified with phytosterols.

Stigmasterol is a type of plant sterol or phytosterol, which is a steroid compound that is naturally occurring in plants. It is found in high concentrations in soybeans, nuts, and some vegetables. Stigmasterol has a similar structure to cholesterol, which is a steroid compound found in animals, but with an additional double bond in its side chain.

Stigmasterol has been studied for its potential health benefits, including its ability to help lower cholesterol levels and reduce the risk of heart disease. It is thought to work by inhibiting the absorption of dietary cholesterol in the gut, which can help to lower overall cholesterol levels in the body.

In addition to its potential health benefits, stigmasterol is also used in the production of some drugs and vaccines, as well as in the manufacture of cosmetics and personal care products.

Sitosterols are a type of plant sterol or phytosterol that are structurally similar to cholesterol, a steroid lipid found in animals. They are found in small amounts in human diets, primarily in vegetable oils, nuts, seeds, and avocados. Sitosterols are not synthesized by the human body but can be absorbed from the diet and have been shown to lower cholesterol levels in the blood when consumed in sufficient quantities. This is because sitosterols compete with cholesterol for absorption in the digestive tract, reducing the amount of cholesterol that enters the bloodstream. Some margarines and other foods are fortified with sitosterols or other phytosterols to help reduce cholesterol levels in people with high cholesterol.

Cholesterol is a type of lipid (fat) molecule that is an essential component of cell membranes and is also used to make certain hormones and vitamins in the body. It is produced by the liver and is also obtained from animal-derived foods such as meat, dairy products, and eggs.

Cholesterol does not mix with blood, so it is transported through the bloodstream by lipoproteins, which are particles made up of both lipids and proteins. There are two main types of lipoproteins that carry cholesterol: low-density lipoproteins (LDL), also known as "bad" cholesterol, and high-density lipoproteins (HDL), also known as "good" cholesterol.

High levels of LDL cholesterol in the blood can lead to a buildup of cholesterol in the walls of the arteries, increasing the risk of heart disease and stroke. On the other hand, high levels of HDL cholesterol are associated with a lower risk of these conditions because HDL helps remove LDL cholesterol from the bloodstream and transport it back to the liver for disposal.

It is important to maintain healthy levels of cholesterol through a balanced diet, regular exercise, and sometimes medication if necessary. Regular screening is also recommended to monitor cholesterol levels and prevent health complications.

Flame Ionization is not a medical term, but rather a scientific technique used in analytical chemistry to detect and measure the presence of certain organic compounds. It is based on the principle that when an organic compound is introduced into a flame, it breaks down into ions and electrons, creating an electrical current that can be measured. This technique is often used in gas chromatography to identify and quantify volatile organic compounds (VOCs) in biological samples such as breath, blood, or urine. However, it is not typically used as a diagnostic tool in medicine.

'Aloe' is the common name for a genus of succulent plants that belong to the family Asphodelaceae. The most widely recognized species is Aloe vera, which has been used for medicinal and therapeutic purposes for centuries.

Aloe vera, also known as "true aloe" or "medical aloe," contains a clear gel inside its leaves that is made up of 99% water and a complex mixture of glucomannans, acemannan, polymannose, anthraquinones, enzymes, sugars, sterols, vitamins, and minerals. This gel has been used topically to soothe skin irritations, burns, and other dermatological conditions due to its anti-inflammatory, moisturizing, and antimicrobial properties.

In addition to its topical uses, aloe vera extracts have also been studied for their potential internal health benefits, including improving digestion, boosting the immune system, and providing antioxidant effects. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines.

It's important to note that not all aloe products are created equal, and some may contain additives or contaminants that can cause adverse reactions. Always consult with a healthcare professional before using aloe vera or any other natural remedy for medicinal purposes.

Corn oil is a type of vegetable oil that is extracted from the germ of corn (maize). It is rich in polyunsaturated fat, particularly linoleic acid, and contains about 25% saturated fat. Corn oil has a high smoke point, making it suitable for frying and baking. It is also used as an ingredient in margarine, salad dressings, and other food products. In addition to its use as a food product, corn oil is sometimes used topically on the skin as a moisturizer or emollient.

Medical definitions generally do not include plant oils as a specific term. However, in a biological or biochemical context, plant oils, also known as vegetable oils, are defined as lipid extracts derived from various parts of plants such as seeds, fruits, and leaves. They mainly consist of triglycerides, which are esters of glycerol and three fatty acids. The composition of fatty acids can vary between different plant sources, leading to a range of physical and chemical properties that make plant oils useful for various applications in the pharmaceutical, cosmetic, and food industries. Some common examples of plant oils include olive oil, coconut oil, sunflower oil, and jojoba oil.

'Erigeron' is a genus of flowering plants in the daisy family, Asteraceae. It includes over 400 species that are commonly known as fleabanes or ragworts. These plants are native to North and South America, with some species found in Europe and Asia. They are herbaceous annuals, biennials, or perennials that typically grow between 15 cm to 60 cm tall. The flowers of Erigeron species are small and daisy-like, with a white, pink, purple, or blue ray florets surrounding a yellow or brown disk floret.

While 'Erigeron' is a genus of plants and not a medical term, some species have been used in traditional medicine for their alleged medicinal properties. For example, Erigeron canadensis (Canada fleabane) has been used to treat various conditions such as skin irritations, coughs, and colds. However, it is important to note that the use of Erigeron species for medicinal purposes should be done under the guidance of a healthcare professional, as there is limited scientific evidence supporting their effectiveness and safety.

Chromatography, supercritical fluid (SFC) is a type of chromatographic technique that uses supercritical fluids as the mobile phase to separate and analyze components of a mixture. A supercritical fluid is a substance that is maintained at temperatures and pressures above its critical point, where it exhibits properties of both a gas and a liquid, making it an ideal medium for separations due to its low viscosity, high diffusivity, and tuneable solvating strength.

In SFC, the supercritical fluid, typically carbon dioxide (CO2) due to its mild critical point conditions, is used to elute analytes from a stationary phase, such as a silica or polymer-based column. The interactions between the analytes and the stationary phase, along with the properties of the supercritical fluid, determine the separation efficiency and resolution of the technique.

SFC has several advantages over traditional liquid chromatography (LC) techniques, including faster analysis times, lower solvent consumption, and the ability to analyze a wider range of polar and nonpolar compounds. SFC is commonly used in the pharmaceutical industry for drug discovery and development, as well as in environmental, food, and chemical analyses.

Esterification is a chemical reaction that involves the conversion of an alcohol and a carboxylic acid into an ester, typically through the removal of a molecule of water. This reaction is often catalyzed by an acid or a base, and it is a key process in organic chemistry. Esters are commonly found in nature and are responsible for the fragrances of many fruits and flowers. They are also important in the production of various industrial and consumer products, including plastics, resins, and perfumes.

Sterols are a type of organic compound that is derived from steroids and found in the cell membranes of organisms. In animals, including humans, cholesterol is the most well-known sterol. Sterols help to maintain the structural integrity and fluidity of cell membranes, and they also play important roles as precursors for the synthesis of various hormones and other signaling molecules. Phytosterols are plant sterols that have been shown to have cholesterol-lowering effects in humans when consumed in sufficient amounts.

LDL, or low-density lipoprotein, is often referred to as "bad" cholesterol. It is one of the lipoproteins that helps carry cholesterol throughout your body. High levels of LDL cholesterol can lead to a buildup of cholesterol in your arteries, which can increase the risk of heart disease and stroke.

Cholesterol is a type of fat (lipid) that is found in the cells of your body. Your body needs some cholesterol to function properly, but having too much can lead to health problems. LDL cholesterol is one of the two main types of cholesterol; the other is high-density lipoprotein (HDL), or "good" cholesterol.

It's important to keep your LDL cholesterol levels in a healthy range to reduce your risk of developing heart disease and stroke. A healthcare professional can help you determine what your target LDL cholesterol level should be based on your individual health status and risk factors.

In a medical context, "nuts" are typically referred to as a type of food that comes from dry fruits with one seed in them. They are often high in healthy fats, fiber, protein, and various essential nutrients. Examples include almonds, walnuts, hazelnuts, cashews, pistachios, and pecans. However, it's important to note that some people may have allergies to certain types of nuts, which can cause serious health problems.

Erythrocyte deformability refers to the ability of red blood cells (erythrocytes) to change shape and bend without rupturing, which is crucial for their efficient movement through narrow blood vessels. This deformability is influenced by several factors including the cell membrane structure, hemoglobin concentration, and intracellular viscosity. A decrease in erythrocyte deformability can negatively impact blood flow and oxygen delivery to tissues, potentially contributing to various pathological conditions such as sickle cell disease, diabetes, and cardiovascular diseases.

Squalene is a organic compound that is a polyunsaturated triterpene. It is a natural component of human skin surface lipids and sebum, where it plays a role in maintaining the integrity and permeability barrier of the stratum corneum. Squalene is also found in various plant and animal tissues, including olive oil, wheat germ oil, and shark liver oil.

In the body, squalene is an intermediate in the biosynthesis of cholesterol and other sterols. It is produced in the liver and transported to other tissues via low-density lipoproteins (LDLs). Squalene has been studied for its potential health benefits due to its antioxidant properties, as well as its ability to modulate immune function and reduce the risk of certain types of cancer. However, more research is needed to confirm these potential benefits.

Anticholesteremic agents are a class of medications that are used to lower the levels of cholesterol and other fats called lipids in the blood. These medications work by reducing the production of cholesterol in the body, increasing the removal of cholesterol from the bloodstream, or preventing the absorption of cholesterol in the digestive tract.

There are several types of anticholesteremic agents, including:

1. Statins: These medications work by blocking a liver enzyme that is necessary for the production of cholesterol. Examples of statins include atorvastatin, simvastatin, and rosuvastatin.
2. Bile acid sequestrants: These medications bind to bile acids in the digestive tract and prevent them from being reabsorbed into the bloodstream. This causes the liver to produce more bile acids, which in turn lowers cholesterol levels. Examples of bile acid sequestrants include cholestyramine and colesevelam.
3. Nicotinic acid: Also known as niacin, this medication works by reducing the production of very low-density lipoproteins (VLDL) in the liver, which are a major source of bad cholesterol.
4. Fibrates: These medications work by increasing the removal of cholesterol from the bloodstream and reducing the production of VLDL in the liver. Examples of fibrates include gemfibrozil and fenofibrate.
5. PCSK9 inhibitors: These are a newer class of medications that work by blocking the action of a protein called PCSK9, which helps regulate the amount of cholesterol in the blood. By blocking PCSK9, these medications increase the number of LDL receptors on the surface of liver cells, which leads to increased removal of LDL from the bloodstream.

Anticholesteremic agents are often prescribed for people who have high cholesterol levels and are at risk for heart disease or stroke. By lowering cholesterol levels, these medications can help reduce the risk of heart attack, stroke, and other cardiovascular events.

Azetidines are a class of organic compounds that contain a 4-membered saturated ring with two carbon atoms and two nitrogen atoms. The general structure of an azetidine is R-CH2-CH2-N-R', where R and R' can be hydrogen atoms or any other organic substituents.

Azetidines are relatively rare in nature, but they have attracted significant interest in the field of medicinal chemistry due to their unique structure and potential as building blocks for drug design. Some azetidine-containing compounds have been developed as drugs for various therapeutic indications, such as antibiotics, antivirals, and anti-inflammatory agents.

It's worth noting that the term 'azetidines' can also refer to the class of pharmaceutical compounds that contain an azetidine ring in their structure.

Chromatography, gas (GC) is a type of chromatographic technique used to separate, identify, and analyze volatile compounds or vapors. In this method, the sample mixture is vaporized and carried through a column packed with a stationary phase by an inert gas (carrier gas). The components of the mixture get separated based on their partitioning between the mobile and stationary phases due to differences in their adsorption/desorption rates or solubility.

The separated components elute at different times, depending on their interaction with the stationary phase, which can be detected and quantified by various detection systems like flame ionization detector (FID), thermal conductivity detector (TCD), electron capture detector (ECD), or mass spectrometer (MS). Gas chromatography is widely used in fields such as chemistry, biochemistry, environmental science, forensics, and food analysis.

Hypercholesterolemia is a medical term that describes a condition characterized by high levels of cholesterol in the blood. Specifically, it refers to an abnormally elevated level of low-density lipoprotein (LDL) cholesterol, also known as "bad" cholesterol, which can contribute to the development of fatty deposits in the arteries called plaques. Over time, these plaques can narrow and harden the arteries, leading to atherosclerosis, a condition that increases the risk of heart disease, stroke, and other cardiovascular complications.

Hypercholesterolemia can be caused by various factors, including genetics, lifestyle choices, and underlying medical conditions. In some cases, it may not cause any symptoms until serious complications arise. Therefore, regular cholesterol screening is essential for early detection and management of hypercholesterolemia. Treatment typically involves lifestyle modifications, such as a healthy diet, regular exercise, and weight management, along with medication if necessary.

Dietary cholesterol is a type of cholesterol that comes from the foods we eat. It is present in animal-derived products such as meat, poultry, dairy products, and eggs. While dietary cholesterol can contribute to an increase in blood cholesterol levels for some people, it's important to note that saturated and trans fats have a more significant impact on blood cholesterol levels than dietary cholesterol itself.

The American Heart Association recommends limiting dietary cholesterol intake to less than 300 milligrams per day for most people, and less than 200 milligrams per day for those with a history of heart disease or high cholesterol levels. However, individual responses to dietary cholesterol can vary, so it's essential to monitor blood cholesterol levels and adjust dietary habits accordingly.

A cross-over study is a type of experimental design in which participants receive two or more interventions in a specific order. After a washout period, each participant receives the opposite intervention(s). The primary advantage of this design is that it controls for individual variability by allowing each participant to act as their own control.

In medical research, cross-over studies are often used to compare the efficacy or safety of two treatments. For example, a researcher might conduct a cross-over study to compare the effectiveness of two different medications for treating high blood pressure. Half of the participants would be randomly assigned to receive one medication first and then switch to the other medication after a washout period. The other half of the participants would receive the opposite order of treatments.

Cross-over studies can provide valuable insights into the relative merits of different interventions, but they also have some limitations. For example, they may not be suitable for studying conditions that are chronic or irreversible, as it may not be possible to completely reverse the effects of the first intervention before administering the second one. Additionally, carryover effects from the first intervention can confound the results if they persist into the second treatment period.

Overall, cross-over studies are a useful tool in medical research when used appropriately and with careful consideration of their limitations.

A diet, in medical terms, refers to the planned and regular consumption of food and drinks. It is a balanced selection of nutrient-rich foods that an individual eats on a daily or periodic basis to meet their energy needs and maintain good health. A well-balanced diet typically includes a variety of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.

A diet may also be prescribed for therapeutic purposes, such as in the management of certain medical conditions like diabetes, hypertension, or obesity. In these cases, a healthcare professional may recommend specific restrictions or modifications to an individual's regular diet to help manage their condition and improve their overall health.

It is important to note that a healthy and balanced diet should be tailored to an individual's age, gender, body size, activity level, and any underlying medical conditions. Consulting with a healthcare professional, such as a registered dietitian or nutritionist, can help ensure that an individual's dietary needs are being met in a safe and effective way.

In medicine, "absorption" refers to the process by which substances, including nutrients, medications, or toxins, are taken up and assimilated into the body's tissues or bloodstream after they have been introduced into the body via various routes (such as oral, intravenous, or transdermal).

The absorption of a substance depends on several factors, including its chemical properties, the route of administration, and the presence of other substances that may affect its uptake. For example, some medications may be better absorbed when taken with food, while others may require an empty stomach for optimal absorption.

Once a substance is absorbed into the bloodstream, it can then be distributed to various tissues throughout the body, where it may exert its effects or be metabolized and eliminated by the body's detoxification systems. Understanding the process of absorption is crucial in developing effective medical treatments and determining appropriate dosages for medications.

I'm sorry for any confusion, but "soybeans" are not a medical term. They are a type of legume that is commonly used in agriculture and food production. The medical community might discuss soybeans in the context of nutrition or allergies, but there isn't a formal medical definition for this term.

Here's some general information: Soybeans, scientifically known as Glycine max, are native to East Asia and are now grown worldwide. They are a significant source of plant-based protein and oil. Soybeans contain various nutrients, including essential amino acids, fiber, B vitamins, and minerals like calcium, iron, magnesium, and zinc. They are used in various food products such as tofu, soy milk, tempeh, and miso. Additionally, soybeans are also used in the production of industrial products, including biodiesel, plastics, and inks. Some people may have allergic reactions to soybeans or soy products.

Gerbillinae is a subfamily of rodents that includes gerbils, jirds, and sand rats. These small mammals are primarily found in arid regions of Africa and Asia. They are characterized by their long hind legs, which they use for hopping, and their long, thin tails. Some species have adapted to desert environments by developing specialized kidneys that allow them to survive on minimal water intake.

Monounsaturated fatty acids (MUFAs) are a type of fatty acid that contains one double bond in its chemical structure. The presence of the double bond means that there is one less hydrogen atom, hence the term "unsaturated." In monounsaturated fats, the double bond occurs between the second and third carbon atoms in the chain, which makes them "mono"unsaturated.

MUFAs are considered to be a healthy type of fat because they can help reduce levels of harmful cholesterol (low-density lipoprotein or LDL) while maintaining levels of beneficial cholesterol (high-density lipoprotein or HDL). They have also been associated with a reduced risk of heart disease and improved insulin sensitivity.

Common sources of monounsaturated fats include olive oil, canola oil, avocados, nuts, and seeds. It is recommended to consume MUFAs as part of a balanced diet that includes a variety of nutrient-dense foods.

Deuterium is a stable and non-radioactive isotope of hydrogen. The atomic nucleus of deuterium, called a deuteron, contains one proton and one neutron, giving it an atomic weight of approximately 2.014 atomic mass units (amu). It is also known as heavy hydrogen or heavy water because its hydrogen atoms contain one neutron in addition to the usual one proton found in common hydrogen atoms.

Deuterium occurs naturally in trace amounts in water and other organic compounds, typically making up about 0.015% to 0.018% of all hydrogen atoms. It can be separated from regular hydrogen through various methods such as electrolysis or distillation, and it has many applications in scientific research, particularly in the fields of chemistry and physics.

In medical contexts, deuterium is sometimes used as a tracer to study metabolic processes in the body. By replacing hydrogen atoms in specific molecules with deuterium atoms, researchers can track the movement and transformation of those molecules within living organisms. This technique has been used to investigate various physiological processes, including drug metabolism, energy production, and lipid synthesis.

Can phytosterols be recommended to reduce LDL cholesterol? ... Phytosterol Regimen. % Change in LDL Cholesterola p 36. 148. ... Summary. Phytosterols have been evaluated in over 40 clinical trials. The incorporation of 2 g of phytosterols daily into ... Table 2. Selected Phytosterol-Containing Products a Product (Manufacturer). Phytosterol Content. Product Dosage. ... Phytosterol dosages of 1.6-3 g daily have been shown to reduce LDL cholesterol by 4.1-15% versus placebo within the first month ...
4-dimethyl phytosterols, 4-monomethyl phytosterols, and 4-desmethyl phytosterols based on the location of methyl groups at the ... Phytosterols have a long history of safe use, dating back to Cytellin, the pharmaceutical preparation of phytosterols marketed ... Free phytosterols extracted from oils are insoluble in water, relatively insoluble in oil, and soluble in alcohols. Phytosterol ... "GRAS Notice 000181: Phytosterols" (PDF). Lea, L.J.; Hepburn, P.A. (2006). "Safety evaluation of phytosterol-esters. Part 9: ...
... says a new study from Spain which adds to the safety data surrounding phytosterols. ... Phytosterols stable in functional foods. By Stephen Daniells 22-Mar-2011. - Last updated on 22-Mar-2011 at 16:42. GMT ... Related tags Plant sterols Sterol Phytosterol Cholesterol The stability of plant sterols in functional foods for cholesterol ... Eight commercially available phytosterol-containing ingredients were tested, with the sterols present in esterified or free ...
Phytosterols are good for your health, but humans and other animals are not able to make them themselves. To acquire ... We think phytosterols might make animal membranes more permeable, but so far, that's just wild speculation, adds Dubilier ... "We were also able to exclude that the worms were taking up phytosterols through their skin. It was only then that we realized ... Cholesterol and phytosterol are sterols, fatty compounds essential for many biological processes such as the functioning of ...
PEG-10 phytosterol is an emulsifier that can enhance the texture of skin care formulas & may also deliver anti-aging benefits. ...
... and submitted petitions to the FDA urging it to rethink plans to amend the criteria for making health claims about phytosterols ... Time is running out for cardio claims on free phytosterol supplements * You say stanol, I say sterol… Raisio clashes with ... FDA must abandon blanket approach to phytosterol claims, argue firms. By Elaine Watson 16-Aug-2011. - Last updated on 17-Aug- ... Pfizer respectfully requests the FDA to reconsider phytosterol rule change * ProCaps Laboratories: FDA is wrong about free ...
Phytosterols Market. Phytosterols Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2021. ...
Whole food sources of phytosterols, such as seeds and nuts, are likely superior to supplements, or phytosterol-fortified ... Though nuts and seeds are packed with phytosterols, phytosterols are typically prescribed in butter form. I kid you not. Or, in ... Though nuts and seeds are packed with phytosterols, phytosterols are typically prescribed in butter form. I kid you not. Or, in ... Whole food sources of phytosterols, such as seeds and nuts, are likely superior to supplements, or phytosterol-fortified ...
Phytosterols market size to reach $935 million by 2022 from $490 million in 2015 at a CAGR of 9.62% The market holds ... Phytosterols Market Overview: The global phytosterols market size is expected to reach $935 million by 2022 from $490 million ... and cycloartenol are other popular segments in the global phytosterols market. The rapid growth of phytosterols in food, ... Other prominent phytosterols industry (not profiled in the report) are Connoils LLC, Vitae Caps S.A., Matrix Fine Pvt Ltd, ...
Phytosterols Formula 107 Capsules (240 ct) at Pick n Save. Find quality health products to add to your Shopping List or order ... Aged Garlic Extract Powder ( Bulb ) , Phytosterols . Other Ingredients : Gelatin , Cellulose , Silica and Magnesium Stearate ( ... Kyolic Aged Garlic Extract™ Phytosterols Formula 107 Capsules. 240 ctUPC: 0002354210743 ...
Featuring CardioAid Phytosterols 60 Sgels from Swanson Health Products. ... CardioAid® Phytosterols (providing a minimum 90% plant sterol esters) contains beta-sitosterol, campesterol, sigmasterol, ... Maximum Strength Plant Sterols - Featuring CardioAid Phytosterols. ...
Both adults and children can benefit from these phytosterol nutrients.. Moducare Grape Chewable Tablets are tasty and easy to ...
... including phytosterols. Phytosterols are known to be applied in the treatment of various prostate diseases. The ,i,in vitro,/i ... Sloe (Prunus spinosa L.) extracts are a good source of natural bioactive compounds, including phytosterols. Phytosterols are ... HPLC Analysis of Phytosterols in Prunus spinosa L. Extracts and Their Antiproliferative Activity on Prostate Cancer Cell Lines ... "HPLC Analysis of Phytosterols in Prunus spinosa L. Extracts and Their Antiproliferative Activity on Prostate Cancer Cell Lines ...
Comments to FDAs Proposed Rule on Food Labeling; Health Claim; Phytosterols and Risk of Coronary Heart Disease Comments - FDA ... comments fdas proposed rule food labeling health claim phytosterols and risk coronary heart disease ...
Our findings are very promising because they provide the first proof-of-principle supporting phytosterols supplementation as a ... 2023) Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging. PLOS Biology 21 ... Phytosterols: Plant-Based Compounds May Hold Key to Combating Age-Related Hearing Loss. ... However, further research is needed to validate the effectiveness of phytosterols in mitigating hearing loss in both older mice ...
... phytosterols), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules ... phytosterols))) and phytosterols (Bayer Heart Health Advantage, benecol margarine, cholestatin, stigmasterol (phytosterols)) ... Phytosterols (Herb/Suppl). Brand and Other Names:Bayer Heart Health Advantage, benecol margarine, more...cholestatin, ... encoded search term (phytosterols (Bayer Heart Health Advantage%2C benecol margarine%2C cholestatin%2C stigmasterol ( ...
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Articles taggés avec: phytosterols. 09janvier Cholesterol, phytosterols, malaria, chlorogenic acid and virus Cholesterol und ...
Combination of free plant sterols from glycine max bean (soybean) Helps to support healthy lipid metabolism* Provides antioxidants and essential fatty acids to support cardiovascular health* Provides 896 mg of free plant sterols per daily serving Includes 10 IU of mixed tocopherols per daily serving Provides 1,392 mg o
Phytosterol capsules! These easy-to-take capsules are packed full of plant-based compounds that support heart, prostate and ... Get a daily dose of phytosterols with BulkSupplements ... BulkSupplements Phytosterols are a plant-based compound that ... Phytosterol Supplement Benefits † Phytosterol supplements may help promote cardiovascular and heart health. They may also ... Phytosterol Supplement Benefits † Phytosterol supplements may help promote cardiovascular and heart health. They may also ...
Click to learn how they achieve this as well as to check what are food sources of phytosterols. ... Phytosterols can lower bad LDL cholesterol and decrease your risk of coronary heart disease. ... Phytosterols: Plants "cholesterol". Phytosterols which includes sterols and stanols are chemical compounds similar to ... There are over 40 known phytosterols but beta-sitosterol, campesterol, and stigmasterol are the most well known and the most ...
What are plant phytosterols exactly?. Plant sterols and stanols are phytosterols, a general term for sterols produced in plants ... How do phytosterols lower cholesterol?. Phytosterols (and ergosterols) are another player on the team to lower cholesterol ... Consuming phytosterols is one way that InsideTracker suggests you can lower your total and LDL cholesterol if you are outside ... Phytosterols and zoosterols (cholesterol) differ from each other based on the components of their "tails", a string of attached ...
The global phytosterols market study comprises a detailed value chain analysis for providing a comprehensive market view. The ... Phytosterols possess a chemical structure which is similar to that of cholesterol but phytosterols have an additional alkyl ... The global phytosterols market trends are characterized by the increasing use of phytosterols in food products which is ... Phytosterols possess a chemical structure which is similar to that of cholesterol but phytosterols have an additional alkyl ...
Creative Proteomcis enables the identification of phytosterol species and content determination analysis based on liquid ... Phytosterols are an important part of plants and are a collective name for a variety of phytosterols and their saturated forms ... Phytosterols have strong anti-inflammatory effects on human body, and have the ability to inhibit the absorption of cholesterol ... Our Phytosterols Analysis Service. Absolute quantification: Use external standard method to quantify, and use internal standard ...
Phytosterols are extracted from oils and are insoluble in water. They are used as additives for foods marketed as heart-healthy ... Phytosterol supplements contain compounds that are similar in form to cholesterol and occur naturally in plants. ... Phytosterol supplements contain compounds that are similar in form to cholesterol and occur naturally in plants. Phytosterols ... Phytosterol Supplement Benefits. Phytosterol supplements may help promote cardiovascular and heart health.† They may also ...
Phytosterols: where they are found. I phytosterols are found in the form of Dietary Supplements, but above all in nature in ... Phytosterols: what they are and what they are for. I phytosterols they are plant lipid compounds with a chemical structure very ... Phytosterol consumption and health. Numerous studies have shown that phytosterol intake, both in the form of supplements and in ... sesame and sunflower seeds, as well as flax seed: sesame is the major source of phytosterols. Used dry, in salads, in the form ...
... are the richest natural sources of phytosterols. Actually, a whole-food, plant-based diet provides up to 1,000 mg per day. ... Phytosterol concentrations in vegetable oils.. Common foods high in phytosterols. If you follow a whole-food, plant-based diet ... What are phytosterols?. Phytosterols are compounds naturally present only in plants. Foods from animal sources dont contain ... Which is the richest diet in phytosterols?. Nowadays, most people get 150-800 mg of phytosterols a day from their diet. Vegans ...
Salvesta minu nimi, e-posti- ja veebiaadress sellesse veebilehitsejasse järgmiste kommentaaride jaoks ...
Marine worms can synthesize phytosterols May 04, 2023 Physiology Researchers discover that many animals have the genes to make ...
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