Phenanthrolines
Phenanthrolines are a class of heterocyclic compounds containing two aromatic hydrocarbon rings fused with a third ring consisting of nitrogen atoms, which have been used in the development of various pharmaceutical and chemical research applications, including as antibacterial, antifungal, and antiviral agents, enzyme inhibitors, and chelators.
Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation. (1/803)
Disulfide trapping studies have revealed that the pore-lining (P) segments of voltage-dependent sodium channels undergo sizable motions on a subsecond time scale. Such motions of the pore may be necessary for selective ion translocation. Although traditionally viewed as separable properties, gating and permeation are now known to interact extensively in various classes of channels. We have investigated the interaction of pore motions and voltage-dependent gating in micro1 sodium channels engineered to contain two cysteines within the P segments. Rates of catalyzed internal disulfide formation (kSS) were measured in K1237C+W1531C mutant channels expressed in oocytes. During repetitive voltage-clamp depolarizations, increasing the pulse duration had biphasic effects on the kSS, which first increased to a maximum at 200 msec and then decreased with longer depolarizations. This result suggested that occupancy of an intermediate inactivation state (IM) facilitates pore motions. Consistent with the known antagonism between alkali metals and a component of slow inactivation, kSS varied inversely with external [Na+]o. We examined the converse relationship, namely the effect of pore flexibility on gating, by measuring recovery from inactivation in Y401C+E758C (YC/EC) channels. Under oxidative conditions, recovery from inactivation was slower than in a reduced environment in which the spontaneous YC/EC cross-link is disrupted. The most prominent effects were slowing of a component with intermediate recovery kinetics, with diminution of its relative amplitude. We conclude that occupancy of an intermediate inactivation state facilitates motions of the P segments; conversely, flexibility of the P segments alters an intermediate component of inactivation. (+info)Dietary fish oils inhibit early events in the assembly of very low density lipoproteins and target apoB for degradation within the rough endoplasmic reticulum of hamster hepatocytes. (2/803)
Dietary fish oils inhibited secretion and stimulated intracellular degradation of apolipoprotein (apo)B in hamster hepatocytes, while dietary sunflower oils stimulated secretion and had no effect on degradation of apoB. To investigate the intracellular site at which fish oils act, we have made use of our previous observations that inhibition of degradation by N-acetyl-leucyl-leucyl-norleucinal (ALLN) results in accumulation of apoB in the trans -Golgi membrane and does not stimulate secretion, while inhibition of degradation by o-phenanthroline results in accumulation of apoB in the rough endoplasmic reticulum membrane and stimulates secretion. Thus, ALLN protects apoB which has been diverted from secretion and o -phenanthroline protects apoB which is targetted for secretion. Addition of o -phenantholine to the incubation medium of hepatocytes from fish oil-fed hamsters inhibited degradation of apoB and stimulated its secretion in particles of the density of VLDL, while addition of ALLN had no effect. These observations suggest that dietary fish oils reversibly inhibit early steps in the assembly of very low density lipoprotein precursors and target apoB for degradation in the rough endoplasmic reticulum. (+info)SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. (3/803)
SAG (sensitive to apoptosis gene) was cloned as an inducible gene by 1,10-phenanthroline (OP), a redox-sensitive compound and an apoptosis inducer. SAG encodes a novel zinc RING finger protein that consists of 113 amino acids with a calculated molecular mass of 12.6 kDa. SAG is highly conserved during evolution, with identities of 70% between human and Caenorhabditis elegans sequences and 55% between human and yeast sequences. In human tissues, SAG is ubiquitously expressed at high levels in skeletal muscles, heart, and testis. SAG is localized in both the cytoplasm and the nucleus of cells, and its gene was mapped to chromosome 3q22-24. Bacterially expressed and purified human SAG binds to zinc and copper metal ions and prevents lipid peroxidation induced by copper or a free radical generator. When overexpressed in several human cell lines, SAG protects cells from apoptosis induced by redox agents (the metal chelator OP and zinc or copper metal ions). Mechanistically, SAG appears to inhibit and/or delay metal ion-induced cytochrome c release and caspase activation. Thus, SAG is a cellular protective molecule that appears to act as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species. (+info)Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression. (4/803)
The neutrophil-specific G-protein-coupled chemokine receptors, CXCR1 and CXCR2, bind with high affinity to the potent chemoattractant interleukin-8 (IL-8). The mechanisms of IL-8 receptor regulation are not well defined, although previous studies have suggested a process of ligand-promoted internalization as a putative regulatory pathway. Herein, we provide evidence for two distinct processes of CXCR1 and CXCR2 regulation. Confocal microscopy data showed a redistribution of CXCR1 expression from the cell surface of neutrophils to internal compartments after stimulation with IL-8, whereas stimulation with bacterial lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha) did not induce CXCR1 internalization but instead mediated a significant loss of membrane-proximal CXCR1 staining intensity. To investigate whether proteolytic cleavage was the mechanism responsible for LPS- and TNF-alpha-induced downmodulation of IL-8 receptors, we tested a panel of proteinase inhibitors. The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha-induced loss of CXCR1 and CXCR2 cell surface expression. Metalloproteinase inhibitors also blocked the release of CXCR1 cleavage fragments into the cell supernatants of LPS- and TNF-alpha-stimulated neutrophils. In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes. In contrast, metalloproteinase inhibitors did not affect IL-8-mediated downmodulation of CXCR1 and CXCR2 cell surface expression or receptor signaling. Thus, these findings may provide further insight into the mechanisms of leukocyte regulation during immunologic and inflammatory responses. (+info)Cleavage of a 23S rRNA pseudoknot by phenanthroline-Cu(II). (5/803)
Studying the intricate folding of rRNA within the ribosome remains a complex problem. Phenanthroline-Cu(II) complexes cleave phosphodiester bonds in rRNA in specific regions, apparently especially where the rRNA structure is constrained in some fashion. We have introduced phenanthroline-copper complexes into 50S Escherichia coli ribosomal subunits and shown specific cleavages in the regions containing nucleotides 60-66 and 87-100. This specificity of cleavage is reduced when the ribosome is heated to 80 degrees C and reduced to background when the ribosomal proteins are extracted and the cleavage repeated on protein-free 23S rRNA. It has been suggested that nucleotides 60-66 and 87-95 in E.coli 23S rRNA are involved in a putative pseudoknot structure, which is supported by covariance data. The paired cleavages of nearly equal intensity of these two regions, when in the ribosome, may further support the existence of a pseudoknot structure in the 100 region of 23S rRNA. (+info)The aconitase of yeast. IV. Studies on iron and sulfur in yeast aconitase. (6/803)
Chemical analyses were carried out to determine the active components of the crystalline aconitase [EC 4.2.1.3] of Candida lipolytica. The enzyme contained 2 atoms of non-heme iron, 1 atom of labile sulfur, and 6 sulfhydryl groups per molecule. One atom of the non-heme iron was released by the addition of metal-chelating agents such as sodium citrate, sodium nitrilotriacetate (NTA) or sodium ethylenediaminetetraacetate (EDTA) without loss of the enzyme activity. The non-heme iron and labile sulfur were released by the addition of sulfhydryl reagents such as rho-chloromercuribenzoate (PCMB), sodium mersalyl or urea with loss of the enzyme activity. o-Phenanthroline reacted with the iron atoms in the enzyme at pH 6.0 with loss of the activity. These results show that yeast aconitase is an iron-sulfur protein and that only one of the two non-heme iron atoms is essential for enzyme activity. (+info)Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta2-integrins. (7/803)
The trace element Zinc (Zn2+) has been implicated as a mediator in host defense, yet the molecular basis for its extracellular functions remains obscure. Here, we demonstrate that Zn2+ can induce the adhesion of myelomonocytic cells to the endothelium, as well as to the provisional matrix proteins vitronectin (VN) and fibrinogen (FBG), which are pivotal steps for the recruitment of leukocytes into inflamed/injured tissue. Physiologic concentrations of Zn2+ increased the urokinase receptor (uPAR)-mediated adhesion of myelomonocytic cells to VN, whereas other divalent cations had smaller effects. Zn2+-induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline, as well as by plasminogen activator inhibitor-1 (PAI-1) and a monoclonal antibody (MoAb) against uPAR. These characteristics could be recapitulated with a uPAR-transfected cell line emphasizing the specificity of this receptor system for Zn2+-dependent cell adhesion. Like urokinase (uPA), Zn2+ increased the binding of radiolabeled VN to uPAR-expressing cells, as well as the interaction of VN with immobilized uPAR in an isolated system. Moreover, Zn2+ enhanced leukocytic cell adhesion to FBG and endothelial cell monolayers by activating beta2-integrins. Instead of the direct beta2-integrin activation through the divalent cation binding site, Zn2+-induced integrin activation was mediated via uPAR, a crucial regulator of this system. The present study uncovers for the first time Zn2+-mediated cell adhesion mechanisms that may play a crucial role in modulating leukocyte adhesion to vessel wall components. (+info)Cytosolic Ca2+ movements of endothelial cells exposed to reactive oxygen intermediates: role of hydroxyl radical-mediated redox alteration of cell-membrane Ca2+ channels. (8/803)
1. The mode of action of reactive oxygen intermediates in cysosolic Ca2+ movements of cultured porcine aortic endothelial cells exposed to xanthine/xanthine oxidase (X/XO) was investigated. 2. Cytosolic Ca2+ movements provoked by X/XO consisted of an initial Ca2+ release from thapsigargin-sensitive intracellular Ca2+ stores and a sustained Ca2+ influx through cell-membrane Ca2+ channels. The Ca2+ movements from both sources were inhibited by catalase, cell-membrane permeable iron chelators (o-phenanthroline and deferoxamine), a *OH scavenger (5,5-dimethyl-1-pyrroline-N-oxide), or an anion channel blocker (disodium 4, 4'-diisothiocyano-2, 2'-stilbenedisulphonic acid), suggesting that *O2- influx through anion channels was responsible for the Ca2+ movements, in which *OH generation catalyzed by intracellular transition metals (i.e., Haber-Weiss cycle) was involved. 3. After an initial Ca2+ elevation provoked by X/XO, cytosolic Ca2+ concentration decreased to a level higher than basal levels. Removal of X/XO slightly enhanced the Ca2+ decrease. Extracellular addition of sulphydryl (SH)-reducing agents, dithiothreitol or glutathione, after the removal of X/XO accelerated the decrement. A Ca2+ channel blocker, Ni2+, abolished the sustained increase in Ca2+, suggesting that Ca2+ influx through cell-membrane Ca2+ channels was extracellularly regulated by the redox state of SH-groups. 4. The X/XO-provoked change in cellular respiration was inhibited by Ni2+ or dithiothreitol as well as inhibitors of Haber-Weiss cycle, suggesting that Ca2+ influx was responsible for *OH-mediated cytotoxicity. We concluded that intracellular *OH generation was involved in the Ca2+ movements in endothelial cells exposed to X/XO. Cytosolic Ca2+ elevation was partly responsible for the oxidants-mediated cytotoxicity. (+info)Phenanthrolines are a class of heterocyclic compounds containing two aromatic hydrocarbon rings fused with a third ring consisting of nitrogen atoms, which have been used in the development of various pharmaceutical and chemical research applications, including as antibacterial, antifungal, and antiviral agents, enzyme inhibitors, and chelators.
Phenanthrolines are a class of compounds that contain a phenanthrene core with two amine groups attached to adjacent carbon atoms. They are known for their ability to form complexes with metal ions and have been widely used in the field of medicinal chemistry as building blocks for pharmaceuticals, particularly in the development of antimalarial drugs such as chloroquine and quinine. Additionally, phenanthrolines have also been explored for their potential use in cancer therapy due to their ability to interfere with DNA replication and transcription. However, it's important to note that specific medical uses and applications of phenanthrolines will depend on the particular compound and its properties.
1,10-Phenanthroline
Phenanthroline is a stronger base than bipy. According to one ligand ranking scale, phen is a weaker donor than bipy. Several ... 1,10-Phenanthroline (phen) is a heterocyclic organic compound. It is a white solid that is soluble in organic solvents. The 1, ... Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric ... 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium. A variety of substituted ...
Bathocuproine
Case, Francis H.; Brennan, James A. (June 1954). "SUBSTITUTED 1, 10-PHENANTHROLINES. VII. SYNTHESIS OF CERTAIN PHENANTHROLINES ... Like 1,10-phenanthroline, bathocuproine is a bidentate chelating ligand. The two methyl groups flank the nitrogen centers, such ... Bathocuproine is a derivative of 1,10-phenanthroline with two methyl groups and two phenyl groups in the 2,9 and 4,7 positions ...
Nicola Armaroli
... , Photoactive mono- and polynuclear Cu(I)-phenanthrolines. A viable alternative to Ru(II)-polypyridines?. In: ...
Neocuproine
Phenanthroline ligands were first published in the late 19th century, and the derivatives substituted at the 2 and 9 positions ... doi:10.1038/sj.bjp.0701218 Pallenberg, A. J.; Marschner, T. M.; Barnhart, D. M. (1997). "Phenanthroline complexes of the d10 ... Relative to 1,10-phenanthroline, neocuproine bears steric bulk flanking the nitrogen donor sites. A major consequence is that ... In the early 1930s, phenanthroline derivatives became known for their use as colorimetric indicators for many transition metals ...
Chloride channel opener
Duszyk M, MacVinish L, Cuthbert AW (October 2001). "Phenanthrolines--a new class of CFTR chloride channel openers". British ... An example is 1,10-phenanthroline, which activates Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels ...
2,2′-Bipyridine
2,2'-Biquinoline 1,10-Phenanthroline Constable; Housecroft (2019). "The Early Years of 2,2'-Bipyridine-A Ligand in its Own ...
Tris(bipyridine)iron(II) chloride
Addition of cyanide to this solution precipitates solid Fe(bipy)2(CN)2. Tris(o-phenanthroline)iron(II) Batten, Stuart R.; ... Schilt, Alfred A. (1970). "Dicyanobis(1,10‐phenanthroline)Iron(II) and Dicyanobis(2,2′‐bipyridine)iron(II)". Inorganic ...
Alan Brisdon
"New macrocyclic Schiff-base complexes incorporating a phenanthroline unit. Part 2: Template synthesis of some manganese(II) ...
Nickel(II) chromate
For instance, with 1,10-phenanthroline it can form triclinic olive-colored crystals of [Ni(1,10-phenanthroline)CrO4•3H2O]•H2O, ... orange crystals of Ni(1,10-phenanthroline)3Cr2O7•3H2O, and yellow powdered Ni(1,10-phenanthroline)3Cr2O7•8H2O. Perry, Dale L. ( ...
Transition metal complexes of 2,2'-bipyridine
The related N,N-heterocyclic ligand phenanthroline forms similar complexes. With respective pKa's of 4.86 and 4.3 for their ... conjugate acids, phenanthroline and bipy are of comparable basicity. 2,2'-Biquinoline is closely related to bipy as a ligand. ...
Belousov-Zhabotinsky reaction
Ferroin, a complex of phenanthroline and iron, is a common indicator. These reactions, if carried out in petri dishes, result ...
GFS Chemicals
Aided by phenanthroline indicators, he produced hexanitratocerate as a primary standard. Studies of periodic acid, iodic acid, ... Smith started producing commercial quantities of 1,10-phenanthroline and its derivatives, producing a range of indicators for ...
Tetrasodium tris(bathophenanthroline disulfonate)ruthenium(II)
This compound is an extension of the phenanthroline series of coordination compounds. Ruthenium(II) tris(bathophenanthroline ... Originally, the ruthenium transition metal complex, ruthenium(II) tris(4,7-diphenyl-1,10-phenanthroline disulfonate) also ...
Alkyne metathesis
Specifically, compound 29 could be isolated upon addition of 1,10-phenanthroline. As a result, terminal alkynes can not be ...
Phanquinone
It is a yellowish solid derived by oxidation of 4,7-phenanthroline.[citation needed] It has been investigated as both ... Phenanthrolines, Quinones, Bipyridines, Enones, All stub articles, Antiinfective agent stubs). ...
Silicon tetraazide
10-phenanthroline. As the hemiacetonitrile solvatated isolated compound expels solvent at 100 °C, and shows then in the DSC ... 10-phenanthroline. The bis(triphenylphosphino)iminium hexaazidosilicate salt [(Ph3P)2N]2[Si(N3)6] on the other hand is ... 10-phenanthroline will result in stable silicon tetraazide adducts. Other bases such as pyridine and tetramethylethylenediamine ...
Spin crossover
Edgar Koenig & K. Madeja (1967). "5T2-1A1 Equilibriums in some iron(II)-bis(1,10-phenanthroline) complexes". Inorg. Chem. 6 (1 ...
Praseodymium acetylacetonate
It can form the green complex Pr(acac)3(phen) with o-phenanthroline. N.K. Dutt; P. Banyopadhyay (May 1964). "Chemistry of the ... P. C. Christidis; I. A. Tossidis; D. G. Paschalidis; L. C. Tzavellas (1998-09-15). "Tris(acetylacetonato)(1,10-phenanthroline) ... cerium(III) and Tris(acetylacetonato)(1,10-phenanthroline)praseodymium(III)". Acta Crystallographica Section C Crystal ...
Catenane
The bis-macrocycle (red) contains two phenanthroline units in a crown ether chain. The interlocking ring is self-assembled when ... two more phenanthroline units with alkene arms coordinate through a copper(I) complex followed by a metathesis ring closing ...
Ferroin
... is the chemical compound with the formula [Fe(o-phen)3]SO4, where o-phen is an abbreviation for 1,10-phenanthroline, a ... The redox potential of the iron-phenanthroline complex can be varied between +0.84 V and +1.10 V by adjusting the position and ... Ferroin sulfate may be prepared by combining phenanthroline to ferrous sulfate in water. 3 phen + Fe2+ → [Fe(phen)3]2+ The main ... Nitroferroin, the complex of iron(II) with 5-nitro-1,10-phenanthroline, has transition potential of +1.25 volts. It is more ...
List of English inventions and discoveries
Sigman DS, Kuwabara MD, Chen CH, Bruice TW (1991). "[20] Nuclease activity of 1,10-phenanthroline-copper in study of protein- ... DNA interactions". Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions. Methods in Enzymology ...
I-motif DNA
Phenanthroline derivatives bind to the C:C base pair, leading to a decrease in the binding constant lower than that of a normal ... These cores characterize phenanthroline derivatives due to their G4 binding and telomerase inhibiting activity. This activity ...
Alcohol oxidase
Known inhibitors of this enzyme include H2O2, Cu2+, phenanthroline, acetamide, potassium cyanide, or cyclopropanone. SCAO is an ...
Metal carbon dioxide complex
Phenanthroline)Cu(PR3)] catalyst effect C-H carboxylation on terminal alkynes together with Cs2CO3. NHC-Cu-H species to ...
Nitrate chlorides
10-phenanthroline- N , N ′)(thiourea- S )nickel(II)] chloride nitrate diethanol solvate". Acta Crystallographica Section C ... 10-phenanthroline-2-carboxamide Oxime)copper(II) Nitrate". Australian Journal of Chemistry. 50 (10): 1017. doi:10.1071/C97022. ...
Charge-transfer band
Complexes of bipyridine, phenanthroline, and related unsaturated heterocycles often exhibit strong C-T bands. Most famous is Ru ...
Redox indicator
There are two common classes of redox indicators: metal complexes of phenanthroline and bipyridine. In these systems, the metal ...
Indium(III) sulfate
Tri-μ-sulfato-κ6O:O'-bis[aqua(1,10-phenanthroline-κ2N,N')indium(III)] dihydrate, [In2(SO4)3(C12H8N2)2(H2O)2]·2H2O, has a 1,10- ... Shen, Fwu Ming; Lush, Shie Fu (15 September 2010). "Tri-µ-sulfato-κ6O:O'-bis[aqua(1,10-phenanthroline- κ2N,N')indium(III)] ... phenanthroline molecule linked to each indium ion. Two indium ions are linked via three sulfate groups. It forms triclinic ...
Cadmium tetrafluoroborate
10-phenanthroline) cadmium tetrafluoroborate". Fresenius' Zeitschrift für analytische Chemie. 320 (1): 22-28. doi:10.1007/ ... 10-phenanthroline)cadmium tetrafluoroborate". Talanta. 20 (4): 414-416. doi:10.1016/0039-9140(73)80171-7. PMID 18961297. ...
Grignard reagent
The interaction of the Grignard reagent with phenanthroline or 2,2'-biquinoline causes a color change. Grignard reagents react ...
PhenLigandLigandsComplexesDerivativesAbstractBidentateCopperDonorsOrganicCompoundReactionsSodiumIronContentCoordinationFunctionPropertiesMethodFormsActivityMetalActivitiesRutheniumComplexes of 1,10-phenanthrolineCationicTrisMoietyToxicologyEDTAFollowed by titrationReagentsSupramolecularIonsAcetylacetonateZincDescriptorComplexAcidStudiesTopic
Phen11
- 1,10-Phenanthroline (phen) is a heterocyclic organic compound. (wikipedia.org)
- 1,10-Phenanthroline (Phen) is a well-known benchmark ligand and has often been used in the coordination chemistry for the complexation of transition metal ions, such as Fe2+, Ni2+, and Co2+. (thecrucibleonscreen.com)
- Ferroin is the chemical compound with the formula [Fe(o-phen)3]SO4, where o-phen is an abbreviation for 1,10-phenanthroline, a bidentate ligand. (thecrucibleonscreen.com)
- Single crystals of [Co(phen)(3)](IO4)(3)center dot 2H(2)O Were obtained by dissolving the yellow coloured precipitated product (obtained by slowly mixing the separately dissolved tris(1,10-phenanthroline)cobalt(III) chloride with sodium periodate in aqueous medium in 1:3 molar ratio) in hot water and allowing it to evaporate slowly at room temperature. (ua.pt)
- The reaction of 1,10′-phenanthroline (phen), tetrasodium pyrophosphate (Na 4 PPi) and FeCl 2 ·6H 2 O in deionized water yielded the iron(III)-PPi chelate complex, {[Hphen][Fe(phen)(H 2 P 2 O 7 ) 2 ]·2H 2 O} (1). (syr.edu)
- abstract = "The reaction of 1,10′-phenanthroline (phen), tetrasodium pyrophosphate (Na4PPi) and FeCl2·6H2O in deionized water yielded the iron(III)-PPi chelate complex, {[Hphen][Fe(phen)(H2P2O7)2]·2H2O} (1). (syr.edu)
- In the present study, we investigated the antitumor effect and associated molecular mechanisms of the copper (II) complex of salicylate phenanthroline [Cu(sal)(phen)] against hepatocellular carcinoma (HCC). (bvsalud.org)
- English The reactions between equimolar amounts of CuX2 (X = NO3− and CF3SO3−) and two aromatic nitrogen-containing heterocycles differing in the position of nitrogen atoms, 1,7- and 4,7-phenanthroline (1,7- and 4,7-phen), were performed in ethanol/methanol at room temperature. (unifr.ch)
- This work aimed to evaluate the effects of copper(II), manganese(II) and silver(I) complexes coordinated with 1,10-phenanthroline (phen)/1,10- phenanthroline-5,6-dione (phendione) on Fonsecaea spp. (tudublin.ie)
- In the present study, Au(III) and Pt(II) complexes of 1, 10-phenanthroline (phen) were synthesized and used as the test compounds. (anadolu.edu.tr)
- In this study, the stability constants of I : 1 : 1 ternary complexes of Cu(II) with 1,10-phenanthroline (Phen) as the primary ligand, and 2,2'-bipyridyl (Bpy) and some selected a-amino acids [(glycine (Gly), leucine (Leu), glutamine (Gln)] as secondary ligands, were identified in I=0.1 m ionic medium at t=(25 +/- 0.1)degrees C in aqueous solutions, by potentiometry. (uludag.edu.tr)
Ligand5
- In the title compound, [Co(C 7 H 5 O 2 ) 2 (C 14 H 12 N 2 )], the Co II ion is located on a twofold rotation axis and is chelated by a 2,9-dimethyl-1,10-phenanthroline (dmphen) ligand and two benzoate anions in a distorted octa-hedral geometry. (iucr.org)
- Phenanthroline, a rigid and planar organic compound with two fused pyridine rings, has been used as a powerful ligand for metals and a binding agent for DNA/RNA. (wayne.edu)
- What type of ligand is 1/10-phenanthroline? (thecrucibleonscreen.com)
- The ultrafast nonadiabatic dynamics of a prototypical Cu(I)-phenanthroline complex, [Cu(dmp)2]+ (dmp = 2,9-dimethyl-1,10-phenanthroline), initiated after photoexcitation into the optically bright metal-to-ligand charge-transfer (MLCT) state (S3) is investigated using quantum nuclear dynamics. (ncl.ac.uk)
- Photoinduced DNA Cleavage and Photocytotoxic of Phenanthroline-Based Ligand Ruthenium Compounds. (nih.gov)
Ligands2
- Luman, C.R. and Castellano, F.N. (2003) "Phenanthroline Ligands" in Comprehensive Coordination Chemistry II. (wikipedia.org)
- The six nitrogen atoms, originating from three 1,10-phenanthroline ligands (each bidentate) show distorted octahedral geometry around the central Co(III) metal ion. (ua.pt)
Complexes1
- Silver(I) 1,10-Phenanthroline Complexes Are Active against Fonsecaea P" by Ingrid S. Sousa Ingrid S. Sousa, Tatiana D.P. Vieira et al. (tudublin.ie)
Derivatives2
- Alkyllithium reagents form deeply colored derivatives with phenanthroline. (wikipedia.org)
- Optical properties of new 5-(4-phenylethynyl)-substituted-1,10-phenanthroline derivatives. (univ-grenoble-alpes.fr)
Abstract1
- abstract = "An AlPO4 zeotype has been prepared using the aromatic diamine 1,10-phenanthroline and some of its methylated analogues as templates. (southwales.ac.uk)
Bidentate1
- Is 1,10-phenanthroline monodentate or bidentate? (thecrucibleonscreen.com)
Copper1
- The copper (II) complex of salicylate phenanthroline inhibits proliferation and induces apoptosis of hepatocellular carcinoma cells. (bvsalud.org)
Donors3
- In terms of its coordination properties, phenanthroline is similar to 2,2'-bipyridine (bipy) with the advantage that the two nitrogen donors are preorganized for chelation. (wikipedia.org)
- We recently discovered that phenanthroline could be used as a nucleophilic catalyst to access high yielding and diastereoselective α-1,2-cis glycosides through the coupling of hydroxyl acceptors with α-glycosyl bromide donors. (wayne.edu)
- The phenanthroline catalysis system is applicable to a number of furanosyl bromide donors to provide the challenging 1,2-cis substitution products in good yield with high anomeric selectivity. (wayne.edu)
Organic2
- It is a white solid that is soluble in organic solvents….1,10-Phenanthroline. (thecrucibleonscreen.com)
- Ba(TMHD) 2 (phenanthroline) 2 is used as an intermediate for preparing the precursors of metal-organic sources by dissolving in tetrahydrofuran (THF). (ereztech.com)
Compound1
- As compared with pure 1T-MoS2, the compound with a phenanthroline interlayer provides greater activity and better current-voltage efficiency in electrocatalytic hydrogen evolution after heating treatment owing to stabilization of the 1T phase. (ipmnet.ru)
Reactions1
- Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene. (wikipedia.org)
Sodium1
- A rapid, accurate method for the determination of iron using hydroxylamine hydrochloride, sodium acetate buffer, and 1,10-phenanthroline is described. (thecrucibleonscreen.com)
Iron2
Content1
- The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint. (wikipedia.org)
Coordination1
- The function of the phenanthroline unit is to coordinate to metal ions, which can in turn coordinate to other molecules, and allow us to build up complex architectures taking advantage of the coordination characteristics of the metal ions. (europa.eu)
Function1
- What is the function of 1/10-phenanthroline? (thecrucibleonscreen.com)
Properties3
- The synthesis and optical properties of a novel family of 5-substituted-1,10-phenanthroline derivs. (univ-grenoble-alpes.fr)
- The effects on optical properties, of the substitution with electro-withdrawing or -donating substituents in the 5th position of the 1,10-phenanthroline are investigated. (univ-grenoble-alpes.fr)
- These findings indicate that the particular interaction of Pd(II) with phenanthroline confers the best pharmacokinetic and pharmacodynamic properties that make this class of DNA intercalators remarkable inhibitors, even of the resistant cell growth. (unimore.it)
Method1
- What is phenanthroline method? (thecrucibleonscreen.com)
Forms1
- 1,10-Phenanthroline forms a stable complex with Fe(II) ion called ferroin, which is used as an indicator in Fe(II) salt titrations. (thecrucibleonscreen.com)
Activity1
- 1,10-Phenanthroline is an inhibitor of metallopeptidases, with one of the first observed instances reported in carboxypeptidase A. Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. (wikipedia.org)
Metal1
- Substituents at the 2,9 positions confer protection for the attached metal, inhibiting the binding of multiple equivalents of the phenanthroline. (wikipedia.org)
Activities1
- Magnesium ions were required for the ATPase activities of both BchH and BchI+D, and these activities were inhibited 50% by 2 mM o-phenanthroline. (lu.se)
Ruthenium1
- In addition wild-type PYP ( PYP WT), PYP R52G and ALBP were successfully modified with a (η 6 -arene) ruthenium( II ) phenanthroline complex via a maleimide linker. (rsc.org)
Complexes of 1,10-phenanthroline2
- Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline. (uams.edu)
- Two highly sensitive spectrophotometric methods have been developed for the determination of olanzapine (OLP) in pharmaceuticals using cerium(IV) and iron(II) complexes of 1,10-phenanthroline and 2,2´x-bipyridyl as reagents. (uni-mysore.ac.in)
Cationic2
- Cationic palladium phenanthroline complexes catalyze the cycloisomerization of functionalized 1,5- and 1,6-dienes to form cyclopentenes which possess a trisubstituted olefin in good yield and with good selectivity. (organic-chemistry.org)
- The reactions between allyl compounds CH2CHCH2Fn bearing electron-withdrawing functional (Fn) groups and cationic {Pt(aryl)(1,10-phenanthroline)}+ fragments generated in situ are described. (unina.it)
Tris2
- Here, the growth-inhibitory effects of tris-(1,10-phenanthroline) iron (II) complex ([Fe(phen) 3 ] 2+ ), a known commercially available cheap chemical substance, were examined. (nih.gov)
- Inquire TRIS(4 7-DIPHENYL-1 10-PHENANTHROLINE) (cas: 123148-15-2 ) online by filling out the inquiry form, we will get back to you within 24 hours! (musechem.com)
Moiety2
- The emission is strongly dependent on the typical structure of the starting precursor for ZnO synthesis, where one phenanthroline moiety is attached with zinc acetylacetonate hydrate complex. (iisc.ac.in)
- Elegant syntheses have been reported recently for fully conjugated diad systems incorporating the 1,10-phenanthroline moiety as the bidentate ligand and we have described the first molecular rack (molrac) in which two units of the same ligand are spatially separated. (edu.au)
Toxicology1
- An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to o-Phenanthroline (66-71-7). (nih.gov)
EDTA1
- IMP + EDTA + 1,10-phenanthroline, μg/mL. (cdc.gov)
Followed by titration1
- The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint. (wikipedia.org)
Reagents1
- 1. The reagents, 3-butyn-1-ol and 2.0 M ethylmagnesium bromide in tetrahydrofuran , were purchased from Aldrich Chemical Company, Inc. The ethylmagnesium bromide concentration can be easily checked by titration with menthol using 1,10-phenanthroline as indicator. (orgsyn.org)
Supramolecular1
- Copper(I) phenanthroline complexes and supramolecular systems containing fullerenes: Photophysics, photochemistry and potential applications in sustainable energy technologies. (unibo.it)
Ions3
- The preorganized ligand 1,10-phenanthroline-2,9-dicarboxylic acid (PDA) was synthesized and subjected to purity verification for studies into its formation constants with various aqueous metal-ions as well as its metal-ligand complex crystal structure. (uncg.edu)
- The cis-aqua-chloro-bis(N,N'-1,10-phenanthroline-5,6-dione)cobalt(II) nitrate trihydrate (3) and the cis-aqua-bromobis(N,N'-1,10-phenanthroline-5,6-dione)cobalt(II) trifluoro-methanesulfonate tetrahydrate (4), crystalize in the same space group with a similar arrangement of the complex ions. (chalmers.se)
- The separation of these metal ions as their 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline) chelates on an Inertsil ODS column was investigated by using acetonitrile-water (80/20, v/v) containing 0.06 M perchloric acid as mobile phase and diode array spectrophotometric detection at 250-650 nm. (elsevierpure.com)
Acetylacetonate2
- We report yellow-red emission from ZnO nanoparticles synthesized within 5 min of microwave irradiation by using zinc acetylacetonate phenanthroline as the starting precursor material. (iisc.ac.in)
- Two new octa-coordinated red emitting complexes of the type [Ln(acac) 3 (Br 2 -phen)] [acac: acetylacetonate, Br 2 -phen: 4,7-dibromo-1,10-phenanthroline, Ln: Sm(III) and Eu(III)] have been synthesized and characterized. (elsevierpure.com)
Zinc1
- 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium. (wikipedia.org)
Descriptor1
- Phenanthrolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Complex5
- This has been synthesized by reacting a Robson type macrocyclic precursor dicopper(II) complex [Cu2L(H2O)2](ClO4)2 (1) and 1,10-phenanthroline in ethanol. (uea.ac.uk)
- Formation of the iron(II)-1,10-phenanthroline complex in a buffered medium. (iso.org)
- Herein we track the wavepacket dynamics of a prototypical [Cu(2,9-dimethyl-1,10-phenanthroline) 2 ] + complex using TR-XANES. (ncl.ac.uk)
- Formation of the iron(II)-1,10-phenanthroline complex in a buffered (pH value between 3.5 and 4.2). (iso.org)
- A new spirocyclic phosphazene derivative has been synthesized from the reaction of 1,10-phenanthroline-5,6-diol with hexachlorocyclotriphosphazatriene in suitable conditions and the Ru(II) complex of the ligand was prepared and characterized. (yildiz.edu.tr)
Acid1
- Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene. (wikipedia.org)
Studies2
- NMR studies of the hydration of the Co(III)(1,10-phenanthroline-5,6-dione)(3)(3+) ion in water and DMSO are also presented. (chalmers.se)
- Solution ESR, electronic, and ESI-MS spectral studies suggest that 1,10-phenanthroline replaces coordinated water in 1, giving 2. (uea.ac.uk)
Topic1
- This graph shows the total number of publications written about "Phenanthrolines" by people in UAMS Profiles by year, and whether "Phenanthrolines" was a major or minor topic of these publications. (uams.edu)
