*  Difference between revisions of "BioMicroCenter:News" - OpenWetWare
This drop out of regions can cause significant issues for several studies - most notably ChIP analyses - when you are comparing ... I want to thank the researchers and labs that have been very patient as we have struggled running their samples which led us to ... The most concerning issue is a dropout of GC rich regions in clustering. This has been an on-again off-again issue with ...
*  Long-Term Follow-up Study on Drop-out TMD Patients With Self-Administered Questionnaires
Of the 1405 consecutive TMD patients examined in a recent 10-year period, 367 (26.1%) drop-out pati ents or patients identified ... Long-Term Follow-up Study on Drop-out TMD Patients With Self-Administered Questionnaires. ... A group of patients who were judged by the examiner not to need treatment were included as a control group. The main reasons ... Dropouts were divided into two groups: (1) those who failed to show up for their first scheduled appointment after the clinical ...
*  Publications | AIDS Clinical Trials Group
Patient Dropouts. Messer K, Vaida F, Hogan C. "Robust analysis of biomarker data with informative missingness using a two-stage ... "The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute ... "The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute ... "The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute ...
*  Cannabis Therapeutic Program Results of Study with Smoked Marij
Patient Drop-out Rates. Thirtyfour patients continued on to two or more treatment episodes using smoked marijuana. Sixty-four ... The patient elected not to take further delta-8-THC.. Patient Z received twelve treatments over a total of 5 months (2 months ... Patients were first enrolled in October 1983.. Only ten patients were enrolled in this study. Results on this small number ... These patients did, however, contribute information in two areas.. Side Effects. These patients provided reassurance about ...
*  Restoration of class II cavities in primary molar teeth with conventional and resin modified glass ionomer cements: a...
... general Dental caries Care and treatment Research Dental materials Patient outcomes Usage Dental matrices Pediatric dentistry ... Results for class II cavities alone are reported, with GIC showing a higher failure rate (p,0.001). Patient drop out was very ... A total of 69 patients were recruited. After 24 months, 10% of patients were lost to the study and 6.6% of class II ... The drop out rate in this study was very low. The most common reasons for failure were secondary caries and loss of retention. ...
*  Internet-Based Cognitive Behaviour Therapy for Tinnitus Patients Delivered in a Regular Clinical Setting : Outcome and Analysis...
... for patients with lower levels of tinnitus distress. We also explored predictors of dropout from ICBT and if dropout influences ... Early dropouts may need additional management. For help-seeking patients with lower distress, a low-intensity version of ICBT ... Treatment dropout was preceded by an increase in days spent at each treatment step but not by an increased distress. Early ... Patients receiving low-intensity ICBT showed a significant reduction in distress, even when they had low levels of distress ...
*  A review of outcomes of an intracavernosal injection therapy programme - Coombs - 2012 - BJU International - Wiley Online...
The causes of patient dropout from penile self-injection therapy for impotence. J Urol 1999; 162: 1291-4. *CrossRef , ... Patient population: 1412 patients had complete data and constituted the study population. The mean (sd) patient age was 58 (16 ... PATIENTS AND METHODS. Patient population: Men presenting with ED between September 2002 and August 2006 who (i) had failed PDE5 ... In all, 1412 patients had complete data and constituted the study population. Most patients were using Trimix and 89% of Trimix ...
*  IMproved PRegnancy Outcome by Early Detection - Full Text View - ClinicalTrials.gov
Thus, allowing for patient dropout, a study population of 5,000 women is needed. ... certain that the true specificity of the patient population is no less than 95%, a sample size of 4,800 participants is ...
*  Effect of Amiodarone on Clinical Status and Left Ventricular Function in Patients With Congestive Heart Failure | Circulation
Patient Characteristics and Dropouts. Table 1⇓ displays the characteristics of the treatment groups, confirming that they were ... Patient Population. The design of this trial and the characteristics of the enrolled patients have been described previously.8 ... and the placebo patients (○). The numbers below indicate the numbers of patients remaining under follow-up after each year. ... Patients who permanently discontinued study drug were followed to the end of the trial and analyzed by the intention-to-treat ...
*  F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients - The New York Times
Current psychotherapy approaches are often slow and many patients drop out when they don't see results. Studies have shown ... C.J. Hardin, a veteran who served three tours in Iraq and Afghanistan, at a memorial in North Charleston, S.C. He is a patient ... F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients. By DAVE PHILIPPS. NOV. 29, 2016. ... During initial studies, patients went through 12 weeks of psychotherapy, including three eight-hour sessions in which they took ...
*  Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus - Tabular View - ClinicalTrials.gov
To accommodate for 10% patient dropouts and failure of spinal anesthesia, 88 patients were enrolled in each group. Incidence of ... We excluded the patient who failed spinal block, inadequate block, and the patient who had prolong operative time which had to ... All patients gave their informed consent after receiving written information of the study. Orthopedic patients were invited to ... Patients were considered eligible if they were aged between 15-70 yr, ASA physical status I-III, and were scheduled for lower ...
*  Increase in Urine Testing Raises Ethical Questions - The New York Times
"Some of those patients drop out of the practice and some of them stick around," he said. ... The patient could have sold the rest of the prescription.. "There is a lot of information out there," about how to try to beat ... To fool a doctor, a patient might need to take a prescribed drug for only a day or two before a test for it to show up in a ... The samples are coded to keep patients' anonymity. Credit Travis Dove for The New York Times The simpler qualitative tests are ...
*  Understanding of chest pain in microvascular disease proved by cardiac magnetic resonance image (UMPIRE): study protocol for a...
Patient dropouts and the reasons, and patients' compliance will be recorded at three months after randomization. ... we would need a total of 76 patients: 38 patients in the udenafil treatment arm and 38 patients in the control arm. ... Patient population Patients who are at least 18 years of age, have chest pain and positive adenosine-stress CMR, and normal ... After the patients are enrolled in the study, the patients will be randomized to the udenafil treatment group or the placebo ...
*  A six-year prospective randomized study of a nano-hybrid and a conventional hybrid resin composite in Class II restorations
Results: Two patient drop outs with 4 restorations (2TEC, 2TC) were registered during the follow-up. A prediction of the caries ... risk showed that 16 of the evaluated 52 patients were considered as high risk patients. Eight TEC (2 P, 6M) and 6 TC (2P, 4M) ...
*  Here's What's Behind Puma's Crash -- The Motley Fool
However, the recognition of that side effect may be spooking investors given the risk of dehydration and patient dropouts. ... A phase 2 trial combing neratinib with paclitaxel showed that patients treated with that combination outperformed patients ... A year ago, Puma kicked off a 600-patient phase 3 trial that pitted oral neratinib and Roche's (NASDAQOTH:RHHBY) Xeloda head to ... In HER2 positive patients, 39% of those in the neratinib arm showed no remaining evidence of the tumor, versus 23% for ...
*  Treatments of Schizophrenia - Revision Cards in A Level and IB Psychology
Side effects , due to blocking D2 for long period of time , tardive dyskinesia, parkinsons , could lead to patient drop-out due ... As there are fewer side effects, could be more appropriate if not effective , as decreased risk of patient drop out ... Side effects could lead to patient drop-out or spiral into depression ... Paul & Lentz , long term effectiveness , after 4 years, TE patients; 98% released from institutions as opposed to 71% of other ...
*  Dr.Malpani's Blog: February 2014
Why patients dropout after a failed IVF Cycle. *Reflections of an Indian Cancer Surgeon by Dr Luis... ... However, if the patient fails to conceive after the treatment, they abandon the patient, who then feels cheated.. Some of them ... From patient's point of view, seeing a good embryo works as a morale booster. The patient undergoing IVF has been going through ... This causes patients to lose trust in IVF doctors. Patients can easily overcome these hurdles by empowering themselves and ...
*  Predictors of mortality in patients initiating antiretroviral therapy in Durban, South Africa
Patient follow-up time was censored due to patient drop-out or study conclusion. If a patient did not return to the clinic ... Since then, rapid scale-up has occurred and over 2 000 patients are receiving ART at that site. As more patients begin ... can predict which patients are at increased risk of death when they start therapy. Interventions enabling more patients to be ... analysis also included patients who previously initiated ART at sites other than Sinikithemba. Patients with a history of ...
*  Patente US7660631 - Methods and systems for electrical and/or drug stimulation as a therapy for ... - Google Patentes
Intracavernosal injection therapy suffers a high rate of patient dropout, as does the therapeutic application of vacuum ... suffers a high rate of patient dropout. The most commonly used drug is alprostadil. Alprostadil is naturally occurring ... in order to assess patient response to such stimulation. If erection is achieved with stimulation, then the patient may elect ... the patient 208 switches SCU 160 on and off by use of controller 210, which may be handheld. Controller 210 operates to control ...
*  Penicillin, you be illin' - antibiotics naturopathy | Ask MetaFilter
I looked at the abstracts of a few papers and none mentioned significant patient dropout treating tonsillitis with pencillin.. ...
*  Preventing Weight Gain by Lifestyle Intervention in a General Practice Setting: Three-Year Results of a Randomized Controlled...
A total of 457 patients were included (mean age 56 years, 52% female). The dropout rate was 24% in the intervention (NP) group ... All patients included had a body mass index (BMI) between 25 and 40 kg/m2 and a diagnosis of hypertension and/or dyslipidemia. ... This suggests that lifestyle counseling by GPs can help patients prevent weight gain, and is equivalent to an intervention by ... In the majority of patients, lifestyle counseling by providers or NPs results in prevention of weight gain. ...
*  Best Practice No 181 | Journal of Clinical Pathology
... there were significant patient drop outs in the treatment groups, which may have caused selection biases.54 Meta-analysis ... patients with cystinuria could also benefit through a lower urine cystine load. Therefore, patients could be advised to amend ... 36 Urate stones are particularly common in patients after colectomy. A further problem for this class of patient is urine ... Once a patient presents with stones there is a standard sequence of investigations that is appropriate, but this paper will ...
*  FDA Okays New Trials on the Effectiveness of Treating PTSD with Ecstasy | Drugs-Forum
Current psychotherapy approaches are often slow and many patients drop out when they don't see results. Studies have shown ... Magic Mushrooms May 'Reset' Brains of Depressed Patients Patients taking psilocybin to treat depression show reduced symptoms ... Re: F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients. It s a great step I think. MDMA helped me (as a ... Re: F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients. Yes, it s short-term solution. That s why it s called ...
*  Henry C. Lee, MD | Stanford Medicine Profiles
Outcomes were most affected by patient dropout from infertility treatments-SITA was preferred when dropout was less than 9% per ... Ligation occurred in 43% of patients with birth weight ≤ 750 g, in 24% of patients weighing between 715 and 1,000 g, and in 12 ... These two patients also had significant laboratory abnormalities compared to patients with more typical presentations resulting ... Multimodality Renal Failure in a Patient with OEIS Complex. AJP reports Santoro, J. D., Chao, S., Hsieh, M. H., Lee, H. C. 2015 ...
*  Assessing the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud iTu, to reduce health...
Information on potential sources of bias such as non-response and patient dropout will be collected throughout the study. Since ... Evaluation of a computerized contraceptive decision aid for adolescent patients. Patient Educ Couns 1999;38:227-39.doi:10.1016/ ... Understanding patient and stakeholder engagement roles for participating in "Research Done Differently" with the patient- ... 28 Interactive patient-centred systems can also respond to a patient's unique needs and risk profiles, tailor health ...

(1/869) Pediatric discharge against medical advice in Bouake Cote d'Ivoire, 1980-1992.

Discharge information was obtained from pediatric ward logbooks of the Centre Hospitalier Regional de Bouake from 1982 to 1992. While number of children admitted per month and discharge diagnosis remained relatively stable throughout the period, the proportion of children who left the hospital against medical advice increased by nearly 5 times during the 11-year period to over 12% of all pediatric admissions. The proportion of discharges against medical advice decreased to 10% of all pediatric admissions after institution of a programme to provide essential drugs at cost to patients (previously only available from private pharmacies). Most children who were taken from the hospital left within the first two days of hospitalization. The admission diagnoses of these children suggest that most had serious, life-threatening illness and that they left the hospital prior to having received adequate treatment. The increase in pediatric ward discharge against medical advice occurred simultaneously with serious budgetary shortfalls in the hospital resulting in inadequacy of medicines and basic equipment. Hospital staff suspected that most of the discharges against medical advice were caused by families being unable to afford the purchase of medicines and supplies necessary for inpatient treatment. It is suggested that widespread policies of decreasing funding for basic curative services in public hospitals may be associated with a substantial increase in preventable child mortality.  (+info)

(2/869) Failure of acetylmethadol in treatment of narcotic addicts due to nonpharmacologic factors.

Acetylmethadol, a new narcotic substitute, has a longer duration of action than methadone. Seventeen subjects, former heroin users currently under methadone treatment, entered a study of the toxicity and efficacy of this drug. Only nine subjects completed the assessment phase of the study and began the acetylmethadol phase, and only one completed the 8-week study phase. Hence, no conclusions can be drawn about acetylmethadol's efficacy. The high attrition rate was unrelated to pharmacologic factors; the subjects were concerned that if this drug was effective there would be no methadone to take home and hence no opportunity to trade, sell or "play with" (that is, combine with other drugs) the latter. This study emphasizes the difficulty in determining the efficacy of specific drug treatments for opiate-dependent patients.  (+info)

(3/869) A randomised controlled trial of specialist health visitor intervention for failure to thrive.

AIMS: To determine whether home intervention by a specialist health visitor affects the outcome of children with failure to thrive. METHODS: Children referred for failure to thrive were randomised to receive conventional care, or conventional care and additional specialist home visiting for 12 months. Outcomes measured were growth, diet, use of health care resources, and Bayley, HAD (hospital anxiety and depression), and behavioural scales. RESULTS: Eighty three children, aged 4-30 months, were enrolled, 42 received specialist health visitor intervention. Children in both groups showed good weight gain (mean (SD) increase in weight SD score for the specialist health visitor intervention group 0.59 (0.63) v 0.42 (0.62) for the control group). Children < 12 months in the intervention group showed a higher mean (SD) increase in weight SD score than the control group (0.82 (0.86) v 0.42 (0.79)). Both groups improved in developmental score and energy intake. No significant differences were found for the primary outcome measures, but controls had significantly more dietary referrals, social service involvement, and hospital admissions, and were less compliant with appointments. CONCLUSIONS: The study failed to show that specialist health visitor intervention conferred additional benefits for the child. However, the specialist health visitor did provide a more coordinated approach, with significant savings in terms of health service use. Problems inherent to health service research are discussed.  (+info)

(4/869) Walking training for intermittent claudication in diabetes.

OBJECTIVE: Walking training (WT) is an established treatment for patients with intermittent claudication (IC). Abnormalities specific to diabetes, such as a relative preponderance of distal lesions and the contribution of microcirculatory disease, might well influence the results of WT. We compared changes in walking distance during WT in diabetic patients with those in nondiabetic control subjects. RESEARCH DESIGN AND METHODS: In consecutive patients with limiting IC and proven peripheral vascular disease, 33 patients with diabetes were compared with 136 control subjects during a half-year supervised WT program. Walking parameters were determined every 2 months, while vascular parameters were obtained at the start and end of the program. RESULTS: Of the 33 diabetic patients, 25 (76%) completed the program, as did 87 of the 136 (64%) control subjects. Thereafter, the symptom-free walking distance and the maximum walking distance (MWD) were significantly increased in diabetic patients from 142 +/- 30 to 339 +/- 57 m and from 266 +/- 39 to 603 +/- 52 m, respectively, and in control subjects from 126 +/- 8 to 400 +/- 39 m and from 292 +/- 18 to 628 +/- 36 m, respectively. The relative gain in MWD was 88% greater in those with diabetes. The vascular parameters were comparable for both groups before and after WT. CONCLUSIONS: WT is an effective treatment for IC, with a greater relative gain in diabetic patients.  (+info)

(5/869) Risk factors for neck and upper limb disorders: results from 24 years of follow up.

OBJECTIVES: To investigate associations between different potential risk factors, related and not related to work, and disorders of the neck and upper extremities occurring up to 24 years later. METHODS: The study comprised 252 women and 232 men, Swedish citizens, 42-59 years of age and in a broad range of occupations. Information about potential risk factors was available from a former study conducted in 1969. Data on disorders of the neck, shoulder, and hand-wrist disorders were obtained retrospectively for the period 1970-93. RESULTS: Risk factors were found to differ between the sexes. Among women over-time work, high mental workload, and unsatisfactory leisure time were associated with disorders in the neck-shoulder region. Interaction was found between high mental workload and unsatisfactory leisure time. Neck symptoms earlier in life were associated with recurrent disorders. Hand and wrist disorders were associated mainly with physical demands at work. Among men blue collar work and a simultaneous presence of high mental workload and additional domestic workload predicted disorders in the neck-shoulder region. CONCLUSIONS: Factors related and not related to work were associated with disorders of the neck, shoulders, and hands and wrist up to 24 years later in life. These included factors related to working hours which previously have not been noted in this context. Interactions between risk factors both related and not related to work were commonly found.  (+info)

(6/869) Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis.

BACKGROUND: The role of inhaled corticosteroids in the long term management of chronic obstructive pulmonary disease (COPD) is still unclear. A meta-analysis of the original data sets of the randomised controlled trials published thus far was therefore performed. The main question was: "Are inhaled corticosteroids able to slow down the decline in lung function (FEV1) in COPD?" METHODS: A Medline search of papers published between 1983 and 1996 was performed and three studies were selected, two of which were published in full and one in abstract form. Patients with "asthmatic features" were excluded from the original data. Ninety five of the original 140 patients treated with inhaled corticosteroids (81 with 1500 micrograms beclomethasone daily, six with 1600 micrograms budesonide daily, and eight with 800 micrograms beclomethasone daily) and 88 patients treated with placebo (of the initial 144 patients) were included in the analysis. The effect on FEV1 was assessed by a multiple repeated measurement technique in which points of time in the study and treatment effects (inhaled corticosteroids compared with placebo) were investigated. RESULTS: No baseline differences were observed (mean age 61 years, mean FEV1 45% predicted). The estimated two year difference in prebronchodilator FEV1 was +0.034 l/year (95% confidence interval (CI) 0.005 to 0.063) in the inhaled corticosteroid group compared with placebo. The postbronchodilator FEV1 showed a difference of +0.039 l/year (95% CI -0.006 to 0.084). No beneficial effect was observed on the exacerbation rate. Worsening of the disease was the reason for drop out in four patients in the treatment group compared with nine in the placebo group. In the treatment group six of the 95 subjects dropped out because of an adverse effect which may have been related to the treatment compared with two of the 88 patients in the placebo group. CONCLUSIONS: This meta-analysis in patients with clearly defined moderately severe COPD showed a beneficial course of FEV1 during two years of treatment with relatively high daily dosages of inhaled corticosteroids.  (+info)

(7/869) True status of smear-positive pulmonary tuberculosis defaulters in Malawi.

The article reports the results of a study to determine the true outcome of 8 months of treatment received by smear-positive pulmonary tuberculosis (PTB) patients who had been registered as defaulters in the Queen Elizabeth Central Hospital (QECH) and Mlambe Mission Hospital (MMH), Blantyre, Malawi. The treatment outcomes were documented from the tuberculosis registers of all patients registered between 1 October 1994 and 30 September 1995. The true treatment outcome for patients who had been registered as defaulters was determined by making personal inquiries at the treatment units and the residences of patients or relatives and, in a few cases, by writing to the appropriate postal address. Interviews were carried out with patients who had defaulted and were still alive and with matched, fully compliant PTB patients who had successfully completed the treatment to determine the factors associated with defaulter status. Of the 1099 patients, 126 (11.5%) had been registered as defaulters, and the true treatment outcome was determined for 101 (80%) of the latter; only 22 were true defaulters, 31 had completed the treatment, 31 had died during the treatment period, and 17 had left the area. A total of 8 of the 22 true defaulters were still alive and were compared with the compliant patients. Two significant characteristics were associated with the defaulters; they were unmarried; and they did not know the correct duration of antituberculosis treatment. Many of the smear-positive tuberculosis patients who had been registered as defaulters in the Blantyre district were found to have different treatment outcomes, without defaulting. The quality of reporting in the health facilities must therefore be improved in order to exclude individuals who are not true defaulters.  (+info)

(8/869) Depressive symptoms and occurrence of type 2 diabetes among Japanese men.

OBJECTIVE: To examine the relationship between depressive symptoms and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for the next 8 years, and 2,380 (86%) responded to the follow-up survey in 1992. During the follow-up survey, occurrence of type 2 diabetes was diagnosed according to World Health Organization criteria. RESULTS: A total of 41 cases of type 2 diabetes were identified during the 8-year follow-up survey. After controlling for other known risk factors for type 2 diabetes, a proportional hazard analysis indicated that subjects who had moderate or severe levels of depressive symptoms (> or = 48 on the SDS) at baseline had a 2.3 times higher risk of having type 2 diabetes at the follow-up survey than those who were not depressed (< or = 39 on the SDS) (P < 0.05). CONCLUSIONS: Depressive symptoms may be associated with the onset of type 2 diabetes.  (+info)

  • symptoms
  • Methods and Results In the Department of Veterans Affairs cooperative study of amiodarone in congestive heart failure, 674 patients with New York Heart Association class II through IV symptoms and ejection fractions of ≤40% were treated with amiodarone or placebo for a median of 45 months in a randomized, double-blind, placebo-controlled protocol. (ahajournals.org)
  • Patients had, on average, struggled with symptoms for 17 years. (nytimes.com)
  • After three doses of MDMA administered under a psychiatrist's guidance, the patients reported a 56 percent decrease of severity of symptoms on average, one study found . (nytimes.com)
  • METHODS: The 'Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image: (UMPIRE)' trial is a multicenter, prospective, randomized, placebo controlled trial, designed to evaluate the effect of udenafil on myocardial ischemia and symptoms in female patients with MVA. (biomedsearch.com)
  • Typically, elderly patients with depression do not report depressed mood, but instead present with less specific symptoms such as insomnia, anorexia, and fatigue. (wikipedia.org)
  • To meet criteria for a major depressive episode, a patient must have 5 of these 9 symptoms nearly every day for at least 2 weeks. (wikipedia.org)
  • CBT based on this model attempts to reverse patients' symptoms by altering their interpretation of their symptoms and/or the behaviours they engage in as a result. (wikipedia.org)
  • Under intense stress patients with BPD may exhibit transient dissociative or paranoid symptoms. (wikipedia.org)
  • Study
  • Anecdotal reports by a few patients who had used both marijuana cigarettes and THC, rated the effectiveness of the smoked marijuana as comparable to that of the oral THC used in this study. (druglibrary.org)
  • This study evaluated two parallel interventions delivered in regular care: ICBT for tinnitus distress (n=293) and a low-intensity version of ICBT (n=81) for patients with lower levels of tinnitus distress. (diva-portal.org)
  • The present study shows that for a large percentage of our sample of patients, ICI therapy is a successful treatment strategy. (wiley.com)
  • In all, 1412 patients had complete data and constituted the study population. (wiley.com)
  • C.J. Hardin, a veteran who served three tours in Iraq and Afghanistan, at a memorial in North Charleston, S.C. He is a patient in the study of MDMA, also known as Ecstasy, as a treatment for post-traumatic stress disorder. (nytimes.com)
  • All patients gave their informed consent after receiving written information of the study. (clinicaltrials.gov)
  • For example, a recently published study of 800 pain patients treated at a Veterans Affairs facility in North Carolina found that one-quarter of them tested negatively in a urine-screen test for a drug they had been prescribed, while 20 percent of patients tested positively for an illicit drug or a narcotic painkiller that was not prescribed. (nytimes.com)
  • The aim of this study is to identify whether udenafil offers benefits in the treatment of MVA in female patients, who have a perfusion defect in their cardiac magnetic resonance image (CMR), but normal coronary arteries. (biomedsearch.com)
  • We conducted a retrospective cohort study analysing data on patients who presented to McCord Hospital, Durban, and started ART between 1 January 1999 and 29 February 2004. (scielo.org.za)
  • We conducted a retrospective cohort study of all patients who started ART at the Sinikithemba Clinic from 1 January 1999 to 29 February 2004. (scielo.org.za)
  • When looking at patient dropout rates, these inconsistencies can make the data difficult to understand, as patients in one study would be considered completers, but the same patients might be considered non-completers in another study. (wikipedia.org)
  • 2009). Communication: Observational Study: Patient initiation of information: Exploring its role during the mental health intake visit. (wikipedia.org)
  • A WHO study estimates that only 50% of patients suffering from chronic diseases in developed countries follow treatment recommendations. (wikipedia.org)
  • For example, a 2004 UK study reported a 97% compliance rate at the beginning of treatment with statins, but only about 50% of patients were still compliant after six months. (wikipedia.org)
  • Some examples are as follows: Patients who do not satisfy the inclusion and/or exclusion criteria are included in the trial, A patient is randomized to Treatment A, but is treated with Treatment B, Some patients drop out from the study, or Some patients are not compliant, that is, do not take their medication as instructed, and so on. (wikipedia.org)
  • Methods to address missing data make assumptions about the relationship between dropout and study results in order to produce results which account for the missing data. (wikipedia.org)
  • If a patient drops out of the study after the third week, then this value is "carried forward" and assumed to be his or her score for the 5 missing data points. (wikipedia.org)
  • The assumption is that the patients improve gradually from the start of the study until the end, so that carrying forward an intermediate value is a conservative estimate of how well the person would have done had he or she remained in the study. (wikipedia.org)
  • Usually, it is measured by the rate of "dropouts", or patients that forfeit participation in a study due to extreme adverse effects. (wikipedia.org)
  • For instance, cancer patients will generally tolerate an immense amount of pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, will not. (wikipedia.org)
  • Blinding should be appropriate to the study, and is ideally double blind, wherein neither the patient nor doctor is aware of whether they are in the control or test group, eliminating any such psychological effects from the study. (wikipedia.org)
  • To receive the corresponding point, an article should describe the number of withdrawals and dropouts, in each of the study groups, and the underlying reasons. (wikipedia.org)
  • rate
  • The dropout rate was 24% in the intervention (NP) group and 20% in the usual care (GP) group. (acc.org)
  • Thus, due to eCompliance the number of missed doses decrease drastically and the default rate i.e. the rate at which patients drop out of the program also reduces by a huge margin. (wikipedia.org)
  • fail
  • Schema therapy was developed by Jeffrey E. Young for use in treatment of personality disorders and chronic DSM Axis I disorders, such as when patients fail to respond or relapse after having been through other therapies (for example, traditional cognitive behavioral therapy). (wikipedia.org)
  • Under conditions of high stress, borderline patients may fail to appreciate the "whole" of the situation and interpret events in catastrophic and intensely personal ways. (wikipedia.org)
  • clinical trials
  • If udenafil demonstrates cardioprotective effects, it may provide a novel therapeutic option to reduce myocardial ischemia and improve cardiac function in female MVA patients.Trial registration: Clinical Trials.gov: NCT01769482 (registered on 20 November 2012). (biomedsearch.com)
  • A 2013 review found that nearly 1 out of 20 patients receiving a placebo in clinical trials for depression dropped out due to adverse events, which were believed to have been caused by the nocebo effect. (wikipedia.org)
  • medication
  • At the Ameritox lab in Greensboro, N.C., samples are used to determine if patients are taking the proper medication. (nytimes.com)
  • not in citation given] perhaps because people do not feel immediately threatened or, in the case of symptomless conditions such as raised cholesterol levels (hypercholesterolaemia) and raised blood pressure (systemic hypertension), feel no obvious benefits at the time of taking the medicines As patients are asymptomatic, they may not see a need to take medication. (wikipedia.org)
  • Basic demographics data like address and phone number are also recorded into the system along with the schedule of the patient for coming into Operation ASHA's centers to take their medication. (wikipedia.org)
  • When the patients come to the center to take their medication, their fingerprint is scanned along with the fingerprint of the health worker present. (wikipedia.org)
  • She then goes to the patients house to give her the medication and scan her fingerprint alongside. (wikipedia.org)
  • For example, when a patient anticipates a side effect of a medication, he/she can suffer that effect even if the "medication" is actually an inert substance. (wikipedia.org)
  • Psychologic therapies are recommended for elderly patients with depression because of this group's vulnerability to adverse effects and high rates of medical problems and medication use. (wikipedia.org)
  • Only 10 to 40 percent of depressed elderly patients are given medication. (wikipedia.org)
  • responses
  • 3 These apparent benefits are in marked contrast to the negative inotropic and hemodynamic responses to other antiarrhythmic agents in this patient population 4 5 and, with the relative infrequency of proarrhythmic events, 6 have made amiodarone a logical antiarrhythmic agent of choice in the treatment of CHF patients. (ahajournals.org)
  • rates
  • Response rates were lower in pelvic radiation and diabetic patients. (wiley.com)
  • Phase IIb data presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in March 2013 showed similar viral suppression rates of 76% for patients taking 100 mg cenicriviroc, 73% with 200 mg cenicriviroc, and 71% with efavirenz. (wikipedia.org)
  • Non-response rates were higher with cenicriviroc, however, largely due to greater drop-out of patients. (wikipedia.org)
  • Suicide rates are nearly twice as high in depressed patients as in the general population. (wikipedia.org)
  • describe
  • Another specialist, Dr. Daniel Alford, says he typically has a discussion with a patient to describe unexpected test findings and their relevance to pain treatment. (nytimes.com)
  • Pharmacometrics can be defined as that branch of science concerned with mathematical models of biology, pharmacology, disease, and physiology used to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects. (wikipedia.org)
  • initiation
  • Interventions enabling patients to be identified before they develop these clinical markers and earlier initiation of ART will help to ensure maximum benefits of therapy. (scielo.org.za)
  • The factors that have predicted mortality in studies evaluating patients prior to initiation of ART include a low CD4 cell count, high HIV RNA, mild to severe anaemia, low body mass index, elevated aspartate aminotransferase (AST), a history of opportunistic infections, and depression. (scielo.org.za)
  • depression
  • Underuse or misuse of antidepressants and prescribing inadequate dosages are the most common mistakes physicians make when treating elderly patients for depression. (wikipedia.org)
  • Major depression is more common in medically ill patients who are older than 70 years and hospitalized or institutionalized. (wikipedia.org)
  • Due to their high reactivity to environmental stimuli, patients with BPD often experience dramatic and short-lived shifts in their mood, alternating between experiences of euphoria, depression, anxiety, and nervousness. (wikipedia.org)
  • therapy
  • In addition, patients receiving radiation therapy were then allowed to use smoked marijuana. (druglibrary.org)
  • Cognitive behaviour therapy (CBT) can reduce tinnitus distress but is not available for most patients. (diva-portal.org)
  • Background Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy. (ahajournals.org)
  • Conclusions Although amiodarone therapy resulted in a substantial increase in left ventricular ejection fraction in patients with congestive heart failure, this was not associated with clinical benefit in the population as a whole. (ahajournals.org)
  • As experience has grown with the use of amiodarone for the treatment of ventricular arrhythmias in patients with congestive heart failure (CHF), it has been noted that therapy with this agent produced concomitant improvement in measurements of left ventricular function 1 2 and exercise tolerance. (ahajournals.org)
  • Patient dropout is associated with numerous problems, such as: loss of potential patient improvement, poorer outcomes, increased likelihood of over-utilizing resources, and disruption in group therapy settings. (wikipedia.org)
  • effects
  • Cyclically, long waiting lists have shown some increased dropout effects, further exacerbating the problem. (wikipedia.org)
  • Since patients often drop out because they find a treatment doesn't seem to be working for them or because it causes harmful side effects, missing data is often correlated with the treatment's efficacy or safety. (wikipedia.org)
  • When trials throw up results that companies don't like, they are perfectly entitled to hide them from doctors and patients, so we only ever see a distorted picture of any drug's true effects. (wikipedia.org)
  • It has been shown that, due to the nocebo effect, warning patients about side effects of drugs can contribute to the causation of such effects, whether the drug is real or not. (wikipedia.org)
  • chronic
  • Further, patients who discontinue treatment are more likely to be characterized as chronic patients, resulting in over-utilization of services, up to twice as much as "appropriate" terminators. (wikipedia.org)
  • citation needed] This may affect patient health, and affect the wider society when it causes complications from chronic diseases, formation of resistant infections, or untreated psychiatric illness. (wikipedia.org)
  • clinics
  • Some IVF clinics put forth the specious argument that they do not share medical records with the patient as IVF maybe a long drawn out treatment and that if the first cycle of IVF fails , then they need to refer to the records to plan further treatment. (drmalpani.com)
  • Some clinics try to hold on to the patients by holding on to their records. (drmalpani.com)
  • negatively
  • This can lead to lower self-esteem, confidence, and thus their effectiveness which will negatively impact their delivery of treatments to other patients. (wikipedia.org)
  • often
  • There is no current research as to how often this occurs in patient dropout cases. (wikipedia.org)
  • The Patient Protection and Affordable Care Act, often shortened to the Affordable Care Act (ACA) or nicknamed Obamacare, is a United States federal statute enacted by the 111th United States Congress and signed into law by President Barack Obama on March 23, 2010. (wikipedia.org)
  • Concurrent medical problems and lower functional expectations of elderly patients often obscure the degree of impairment. (wikipedia.org)
  • Patients with BPD are often characterized by intense affects, stormy relationships, and impulsive behaviors. (wikipedia.org)
  • Patients with BPD often experience intolerable feelings of emptiness that they attempt to fill with impulsive and self-damaging behaviors, such as substance abuse, risky sexual behavior, uncontrolled spending, or binge eating. (wikipedia.org)
  • physicians
  • However, the majority of physicians do not routinely counsel patients regarding lifestyle modification. (acc.org)
  • Describing the situation as a "murderous disaster", he makes suggestions for action by patients' groups, physicians, academics and the industry itself. (wikipedia.org)
  • Questionnaires
  • The agreements, however, proved to be of limited value, so pain specialists turned to diagnostic questionnaires that were supposedly able to predict whether a patient was likely to abuse a narcotic because of factors like a family history of substance abuse. (nytimes.com)
  • risk
  • Of note is the trend toward a reduction in the combined end point of hospitalizations and cardiac deaths (relative risk, 0.82 [CI, 0.65 to 1. P =.08), which was significant in patients with nonischemic etiology (relative risk, 0.56 [CI, 0.36 to 0. P =.01) and absent in the ischemic group (relative risk, 0.95). (ahajournals.org)
  • A prediction of the caries risk showed that 16 of the evaluated 52 patients were considered as high risk patients. (diva-portal.org)
  • However, the recognition of that side effect may be spooking investors given the risk of dehydration and patient dropouts. (fool.com)
  • Simple clinical and laboratory data independently predict mortality and allow for risk stratification in patients initiating ART in South Africa. (scielo.org.za)
  • As more patients begin treatment, it is important to identify factors that predict a higher risk of mortality so that they can be more closely monitored. (scielo.org.za)
  • Predicting patients at risk of dropping treatment is a difficult task that is still being researched. (wikipedia.org)
  • make
  • Studies have found that almost all patients make a decision about whether to return or not after the intake interview. (wikipedia.org)
  • suggests
  • The substantial reduction in the combined end point of cardiac death plus hospitalizations for heart failure in the nonischemic group suggests possible benefit in these patients. (ahajournals.org)
  • This suggests that lifestyle counseling by GPs can help patients prevent weight gain, and is equivalent to an intervention by NPs. (acc.org)
  • lower
  • For help-seeking patients with lower distress, a low-intensity version of ICBT can be used. (diva-portal.org)
  • Patients were considered eligible if they were aged between 15-70 yr, ASA physical status I-III, and were scheduled for lower limb surgery under spinal anesthesia. (clinicaltrials.gov)
  • efficacy
  • DISCUSSION: The UMPIRE trial is the first randomized controlled trial to evaluate the efficacy of udenafil in female MVA patients. (biomedsearch.com)
  • Evidence is lacking for both efficacy and safety of cannabis and cannabinoids in treating patients with HIV/AIDS or for anorexia associated with AIDS. (wikipedia.org)
  • shown
  • As shown in Table W, only 4.1% of the patients reported mild or no nausea during their first smoked marijuana protected treatment episode. (druglibrary.org)
  • however, only TFP has been shown to change how patients think about themselves in relationships. (wikipedia.org)
  • data
  • As each protocol was changed data forms were also revised in an effort to increase enrollment by reducing any burden of paperwork for investigators and patients. (druglibrary.org)
  • Regulators see most of the trial data, but only from early on in a drug's life, and even then they don't give this data to doctors or patients, or even to other parts of government. (wikipedia.org)
  • trial
  • 2 In a randomized, controlled trial of amiodarone in patients with severe CHF, there was both a survival benefit and a reduction in the number of hospitalizations for heart failure. (ahajournals.org)
  • In contrast to these favorable results with amiodarone, in the recently completed randomized, double-blind, placebo-controlled trial of amiodarone in patients with CHF conducted by the Department of Veterans Affairs Cooperative Studies Program, no improvement was observed in all-cause or sudden death mortality. (ahajournals.org)
  • A year ago, Puma kicked off a 600-patient phase 3 trial that pitted oral neratinib and Roche 's ( NASDAQOTH:RHHBY ) Xeloda head to head against GlaxoSmithKline 's Tykerb and Xeloda. (fool.com)
  • A phase 2 trial combing neratinib with paclitaxel showed that patients treated with that combination outperformed patients treated with Roche's infused Herceptin and generic paclitaxel. (fool.com)
  • Using Bayesian predictive probability to determine whether neratinib would outperform Herceptin in a 300-patient trial shows neratinib would have a 79% likelihood of besting Herceptin. (fool.com)
  • It is normally applied to quantify drug, disease and trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients. (wikipedia.org)
  • Clinical Trial Portals can include patient recruitment management applications that track actual vs projected enrollment, site recruitment plans, IRB/EC submission/approval dates, recruitment material management, outreach tactics and ROI. (wikipedia.org)
  • Also, the per-protocol restricts the comparison of the treatments to the ideal patients, that is, those who adhered perfectly to the clinical trial instructions as stipulated in the protocol. (wikipedia.org)
  • One of the most important problems in analyzing a clinical trial is the occurrence of the dropout. (wikipedia.org)
  • However, it is also important that none of those involved in a clinical trial, whether the researcher, the subject patient or any other involved parties, should allow their own prior expectations to affect reporting of results. (wikipedia.org)
  • research
  • It will also fund the Phase 3 research, which will include at least 230 patients. (nytimes.com)
  • Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by the British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. (wikipedia.org)
  • expectations
  • A nocebo effect is said to occur when negative expectations of the patient regarding a treatment cause the treatment to have a more negative effect than it otherwise would have. (wikipedia.org)
  • positive
  • However, the initial positive results need to be replicated in larger samples, and treatment dropout has not been thoroughly studied. (diva-portal.org)
  • But such talks may have only limited success, and some patients continue to test positive for illicit drugs, said Dr. Alford, who is a professor at Boston University. (nytimes.com)
  • In HER2 positive patients, 39% of those in the neratinib arm showed no remaining evidence of the tumor, versus 23% for Herceptin. (fool.com)
  • substantial increase
  • New funding through the President's Emergency Plan for AIDS Relief (PEPFAR) and the South African government has led to a substantial increase in the number of patients who are able to access ART. (scielo.org.za)
  • In the majority of patients, lifestyle counseling by providers or NPs results in prevention of weight gain. (acc.org)
  • group
  • Of the 1405 consecutive TMD patients examined in a recent 10-year period, 367 (26.1%) drop-out pati ents or patients identified with a control group were sampled. (quintpub.com)
  • A total of 80 patients with proven perfusion defect in adenosine-stress CMR will be randomly assigned to either the udenafil treatment group (daily dose of 100 mg) or the placebo group for three months. (biomedsearch.com)
  • After a defined time period, the patients in the test group are assessed for health improvements in comparison with the control group. (wikipedia.org)
  • better
  • Urine tests are by no means the first technique that doctors have used to try to better monitor how patients are using prescription narcotics. (nytimes.com)
  • For example, it may be used help the patient cope with their disability by better management of rest and activity within the boundaries of the energy constraints of the disorder, and does not actively attempt to improve the patient's physical or psychological capacity. (wikipedia.org)
  • treatments
  • Goldacre writes in the introduction of Bad Pharma that he aims to defend the following: Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analysed using techniques which are flawed by design, in such a way that they exaggerate the benefits of treatments. (wikipedia.org)
  • medications
  • Patients paid for all medications, except for antibiotics for tuberculosis and co-trimoxazole, and for laboratory studies, including CD4 count and HIV RNA. (scielo.org.za)
  • studies
  • The Multidisciplinary Association for Psychedelic Studies , a small nonprofit created in 1985 to advocate the legal medical use of MDMA, LSD, marijuana and other banned drugs, sponsored six Phase 2 studies treating a total of 130 PTSD patients with the stimulant. (nytimes.com)
  • In smoking cessation studies, for example, it is routine to consider all dropouts as failures. (wikipedia.org)
  • Time
  • Given this background, and the amount of time, energy and effort patients invest in IVF treatment, it is surprising to see how apathetic patients are towards seeking and obtaining the medical records of the IVF procedure. (drmalpani.com)
  • The benefits of proper documentation accrue over a long period of time , and are equally beneficial to the doctor as well as the patient. (drmalpani.com)
  • Clinicians experience losses in the form of time spent on patient intakes, missed appointments prior to termination, and other diagnostic work performed. (wikipedia.org)
  • For TB treatment, patients are enrolled into eCompliance by scanning their fingerprints at the time of registration into Operation ASHA's program. (wikipedia.org)
  • protocol
  • In 1981, the Smoked Marijuana Protocol was modified to permit outpatients and marijuana naive' patients to participate. (druglibrary.org)
  • This protocol allowed all patients, regardless of their anticancer treatment, to have access to smoked marijuana. (druglibrary.org)
  • The marijuana cigarette protocol attracted only 119 patients, less than five percent of the total number enrolled in the Cannabis Therapeutic Program. (druglibrary.org)
  • management
  • But he added that he was concerned that doctors, to protect themselves, would use the tests as an excuse to drop, or "fire," patients rather than steer them into addiction treatment or alternative pain management programs. (nytimes.com)
  • adverse
  • Patient demographic information, agents used, erectile function outcomes and adverse events were recorded. (wiley.com)
  • doctors
  • As doctors try to ensure their patients do not abuse prescription drugs, they are relying more and more on sophisticated urine-screening tests to learn which drugs patients are taking and - just as important - which ones they're not. (nytimes.com)
  • Still, doctors say they now face tough choices about what to do with patients when tests show they are not taking prescribed drugs or are mixing them with unapproved drugs or illegal ones. (nytimes.com)
  • I think that it is problematic from an ethical perspective," for doctors to fire patients, said Dr. Chou, a professor at Oregon Health & Science University in Portland. (nytimes.com)
  • Medical cannabis, or medical marijuana, is cannabis and cannabinoids that are recommended by doctors for their patients. (wikipedia.org)