Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.Spastic Paraplegia, Hereditary: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Tuberculosis, Spinal: Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.Paraparesis: Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Quadriplegia: Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.Spinal Cord Compression: Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.Laminectomy: A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.Hysteria: Historical term for a chronic, but fluctuating, disorder beginning in early life and characterized by recurrent and multiple somatic complaints not apparently due to physical illness. This diagnosis is not used in contemporary practice.Wheelchairs: Chairs mounted on wheels and designed to be propelled by the occupant.Myelography: X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.Thoracic Vertebrae: A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.Crutches: Wooden or metal staffs designed to aid a person in walking. (UMDNS,1999)Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Myelitis, Transverse: Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)Arachnoiditis: Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)Tabes Dorsalis: Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)Epidural Space: Space between the dura mater and the walls of the vertebral canal.Paraparesis, Spastic: Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.Cinnarizine: A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Hematoma, Epidural, Spinal: A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Genes, Recessive: Genes that influence the PHENOTYPE only in the homozygous state.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.Constriction: The act of constricting.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Heart Bypass, Left: Diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures.Decompression, Surgical: A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Cerebrospinal Fluid Pressure: Manometric pressure of the CEREBROSPINAL FLUID as measured by lumbar, cerebroventricular, or cisternal puncture. Within the cranial cavity it is called INTRACRANIAL PRESSURE.Spondylitis: Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.Cellulose, Oxidized: A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation.Spinal NeoplasmsAortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Adenosine Triphosphatases: A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.Spinal Injuries: Injuries involving the vertebral column.Kyphosis: Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.Reflex, Babinski: A reflex found in normal infants consisting of dorsiflexion of the HALLUX and abduction of the other TOES in response to cutaneous stimulation of the plantar surface of the FOOT. In adults, it is used as a diagnostic criterion, and if present is a NEUROLOGIC MANIFESTATION of dysfunction in the CENTRAL NERVOUS SYSTEM.Spinal DiseasesAortic Diseases: Pathological processes involving any part of the AORTA.

*  Pressure Ulcer Formation Prevention in Paraplegics Using Computer and Sensory Substitution Via the Tongue. - Full Text View -...

Paraplegia. Skin Ulcer. Skin Diseases. Paralysis. Neurologic Manifestations. Nervous System Diseases. Signs and Symptoms. ..."Paraplegia"&rank=16

*  Paraplegia | Winchester Hospital

Paraplegia is complete or partial paralysis of the lower half of the body. Some people may resume some function. Many people ... Paraplegia is the word used to describe the body's loss of movement and/or feeling. ... with paraplegia may have long-term loss of function. ... Paraplegia. Definition. Paraplegia is the word used to describe ... Paraplegia is most often caused by injury or accident. The chance of injury resulting in paraplegia may be reduced by paying ...

*  Paraplegia | Kendall Regional Medical Center | Miami, FL

Learn more about Paraplegia at Kendall Regional Medical Center DefiniciónCausasFactores de ... Aunque con mayor frecuencia la paraplegia es causada por lesión o accidente, la probabilidad de lesión que provoque paraplegia ... Paraplegia es el término usado para describir la pérdida corporal de movimiento y/o sensación como resultado de daño o trauma ... La paraplegia por lo general es el resultado de un accidente no anticipado. Las personas que participan en deportes de alto ...ía/sp&com.dotmarketing.htmlpage.language=1

*  Boy with acute paraplegia and local tenderness in the back | MediSpot

Boy with acute paraplegia and local tenderness in the back,Medical cases for Medical Students,Learning radiology and Clinical ... Boy with acute paraplegia and local tenderness in the back Monday, September 19, 2011 ... An 11-year-old boy was referred with acute paraplegia and local tenderness over the left costovertebral angle. He had also ... Copyright 2009 : MediSpot: Boy with acute paraplegia and local tenderness in the back ...

*  Paraplegia | Blake Medical Center | Bradenton, FL

Learn more about Paraplegia at Blake Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Paraplegia is most often caused by injury or accident. The chance of injury resulting in paraplegia may be reduced by paying ... Paraplegia is the word used to describe the body's loss of movement and/or feeling. Paraplegia is complete or partial paralysis ... Paraplegia is often the result of an accident. People who participate in high-risk or high-contact sports or those who drive ...

*  spastic paraplegia type 8 - Genetics Home Reference

Spastic paraplegia type 8 is a pure hereditary spastic paraplegia.. Like all hereditary spastic paraplegias, spastic paraplegia ... Spastic paraplegia type 8 likely accounts for only a small percentage of all spastic paraplegia cases. ... Spastic paraplegia type 8 is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell ... GeneReview: Spastic Paraplegia 8. *. Hedera P, Rainier S, Alvarado D, Zhao X, Williamson J, Otterud B, Leppert M, Fink JK. ...

*  Compression Paraplegia: Syphilitic Meningitis

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

*  Quadriplegia and Paraplegia | Regional Medical Center

Learn more about Quadriplegia and Paraplegia at Regional Medical Center of San Jose DefinitionCausesRisk ... Whether it is paraplegia or quadriplegia depends on the location along the spine where the injury occurs:. *Paraplegia-damage ... Quadriplegia and paraplegia are most often caused by spinal cord injuries. But, they can also be caused by diseases, such as:. ... Factors that may increase your chance of quadriplegia and paraplegia include:. *Jobs or sports activities that increase your ...

*  Paraplegia Injury Lawyer Archives - Frekhtman & Associates

Tips from a Paraplegia Injury Lawyer. April 13, 2016 Frekhtman & Associates It's a worst case scenario for many - you wake up ...

*  Fitness, inflammation, and the metabolic syndrome in men with paraplegia.

... Author(s): Manns PJ, McCubbin JA, Williams DP, Manns ... in men with paraplegia. DESIGN: Cross-sectional exploratory design. SETTING: University research laboratory. PARTICIPANTS: ... Twenty-two men (age, 39+/-9y; duration of injury, 17+/-9y; level of injury, T2-L2) with functionally complete paraplegia ...

*  A 76-YEAR-OLD WOMAN WITH PARAPLEGIA - Rémi - 2010 - Brain Pathology - Wiley Online Library

Patients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply. ...

*  Using visual illusion to reduce at-level neuropathic pain in paraplegia.

Abstract Neuropathic pain after spinal cord injury is not well understood and is difficult to treat. One possible cause is mismatch between motor commands and sensory feedback. Thi..

*  Quadriplegia and Paraplegia | Lawnwood Medical Center & Heart Institute | Fort Pierce, FL

Learn more about Quadriplegia and Paraplegia at Lawnwood Medical Center & Heart Institute DefinitionCausesRisk ... Whether it is paraplegia or quadriplegia depends on the location along the spine where the injury occurs:. *Paraplegia-damage ... Quadriplegia and paraplegia are most often caused by spinal cord injuries. But, they can also be caused by diseases, such as:. ... Factors that may increase your chance of quadriplegia and paraplegia include:. *Jobs or sports activities that increase your ...

*  Comisión Europea : CORDIS : Proyectos y Resultados : Roles of spastic paraplegia proteins in organisation of axonal endoplasmic...

Roles of spastic paraplegia proteins in organisation of axonal endoplasmic reticulum. Desde 2016-01-01 hasta 2017-12-31, ... Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER ...

*  Search of: 'spastic paraplegia type 15' OR 'SPG15' OR 'Spastic Paraplegia, Hereditary' - List Results -

spastic paraplegia type 15' OR 'SPG15' OR 'Spastic Paraplegia, Hereditary' (11 records) ..."spastic paraplegia type 15" OR "SPG15" OR "Spastic Paraplegia, Hereditary"

*  I Have Spastic Paraplegia Epilepsy Mental Retardation

Join friendly people sharing true stories in the I Have Spastic Paraplegia Epilepsy Mental Retardation group. Find support ... Do You Have Spastic Paraplegia Epilepsy Mental Retardation? ... I Have Spastic Paraplegia Epilepsy Mental Retardation does not ... A Spastic Paraplegia Epilepsy Mental Retardation anonymous support group with information on diagnosis, treatment, symptoms, ... along with personal stories and experiences with Spastic Paraplegia Epilepsy Mental Retardation. You're not alone. Report Group ...

*  Advanced exoskeleton promises more independence for people with paraplegia | Research News @ Vanderbilt | Vanderbilt...

About 155,000 have paraplegia. The average age at injury is 41 and the estimated lifetime cost when it happens to a person of ... Advanced exoskeleton promises more independence for people with paraplegia. by David Salisbury , Oct. 30, 2012, 8:30 AM , Want ... FES can improve strength in the legs of people with incomplete paraplegia. For complete paraplegics, FES can improve ... paraplegia, Parker Hannafin, prosthetics, rehabilitation, robotics, Shepherd Center, spinal cord injury, wearable robot ...

*  What are the major differences between paraplegia and quadriplegia - Answers on HealthTap

Elson on what are the major differences between paraplegia and quadriplegia: Paraplegia is paralysis of the legs (no movement ... What Are The Major Differences Between Paraplegia And Quadriplegia ... Paraplegia (Definition) Paraplegia = full or complete paralysis of lower half of body. ...Read more ... Paraplegia: Paraplegia = full or complete paralysis of lower half of body. ...Read more ...

*  Hereditary Spastic Paraplegia (HSP) at Miller School of Medicine

Hereditary Spastic Paraplegia (HSP) refers to a group of inherited spinal cord disorders that manifest themselves first as ...

*  NJ Paraplegia Caused by Epidural Hematoma

An emergency MRI diagnosed that the paraplegia was caused by a bleed in the thoracic spine known as an epidural hematoma. ... 3,250,000 Settlement - Medical Malpractice - Paraplegia Caused by Epidural Hematoma. *Date: Spring 2009 ... Emergency surgery was done, but, regrettably, it was too late to reverse the man's permanent paraplegia. ... Home Verdicts & Settlements $3,250,000 Settlement - Medical Malpractice - Paraplegia Caused by Epidural Hematoma ...


Spastic Paraplegia, Hereditary ← SPASTIC PARAPLEGIA 49, AUTOSOMAL RECESSIVE 2.. Diseases ← Nervous System Diseases ← ... Spastic Paraplegia, Hereditary ← SPASTIC PARAPLEGIA 49, AUTOSOMAL RECESSIVE 3.. Diseases ← Nervous System Diseases ← ... Spastic Paraplegia, Hereditary ← SPASTIC PARAPLEGIA 49, AUTOSOMAL RECESSIVE 4.. Diseases ← Congenital, Hereditary, and Neonatal ... Spastic Paraplegia, Hereditary ← SPASTIC PARAPLEGIA 49, AUTOSOMAL RECESSIVE 5.. Diseases ← Congenital, Hereditary, and Neonatal ...

*  Online Hereditary Spastic Paraplegia Consultation | Lybrate

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List of people with paraplegia: This is a list of people who have or had paraplegia.List of diseases (S): This is a list of diseases starting with the letter "S".Rehabilitation in spinal cord injury: When treating a person with a spinal cord injury, repairing the damage created by injury is the ultimate goal. By using a variety of treatments, greater improvements are achieved, and, therefore, treatment should not be limited to one method.Familial thoracic aortic aneurysmUpper-limb surgery in tetraplegia: Upper-limb surgery in tetraplegia includes a number of surgical interventions that can help improve the quality of life of a patient with tetraplegia.LaminectomyHysteria: Hysteria, in its colloquial use, describes unmanageable emotional excesses. Generally, modern medical professionals have given up the use of "hysteria" as a diagnostic category, replacing it with more precisely defined categories such as somatization disorder.Motorized wheelchair: A motorized wheelchair, powerchair, electric wheelchair or electric-powered wheelchair (EPW) is a wheelchair that is propelled by means of an electric motor rather than manual power. Motorized wheelchairs are useful for those unable to propel a manual wheelchair or who may need to use a wheelchair for distances or over terrain which would be fatiguing in a manual wheelchair.Clay-shoveler fracture: Clay-shoveler's fracture is a stable fracture through the spinous process of a vertebra occurring at any of the lower cervical or upper thoracic vertebrae, classically at C6 or C7. In Australia in the 1930s, men digging deep ditches tossed clay 10 to 15 feet above their heads using long handled shovels.Crutch: A crutch is a mobility aid that transfers weight from the legs to the upper body. It is often used for people who cannot use their legs to support their weight, for reasons ranging from short-term injuries to lifelong disabilities.Neuromere: Neuromeres are morphologically or molecularly defined transient segments of the early developing brain. Rhombomeres are such segments that make up the rhombencephalon or hindbrain.AortographyPedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary -, a part of The New York Times Company.Familial aortic dissection: Familial aortic dissection or FAD refers to the splitting of the wall of the aorta in either the arch, ascending or descending portions. FAD is thought to be passed down as an autosomal dominant disease and once inherited will result in dissection of the aorta, and dissecting aneurysm of the aorta, or rarely aortic or arterial dilation at a young age.MyelitisArachnoiditisJean Nageotte: Jean Nageotte (8 February 1866 – 22 July 1948) was a French neuroanatomist born in Dijon.Epidural space: In the spine, the epidural space (from Ancient Greek ἐπί, "on, upon" + dura mater also known as "epidural cavity", "extradural space" or "peridural space") is an anatomic space that is the outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater (which encloses the arachnoid mater, subarachnoid space, the cerebrospinal fluid, and the spinal cord).DrugstoreTraumatic aortic ruptureOpsismodysplasiaIridogoniodysgenesis, dominant type: Iridogoniodysgenesis, dominant type (type 1, IRID1) refers to a spectrum of diseases characterized by malformations of the irido-corneal angle of the anterior chamber of the eye. Iridogoniodysgenesis is the result of abnormal migration or terminal induction of neural crest cells.Spinal decompression: Spinal decompression is the relief of pressure on one or many pinched nerves (neural impingement) of the spinal column.Abdominal aortic aneurysmAAA proteins: For other uses see AAA (disambiguation)Peripheral nerve injury classification: Classification of peripheral nerve injury assists in prognosis and determination of treatment strategy. Classification of nerve injury was described by Seddon in 1943 and by Sunderland in 1951.Status migrainosus: Status Migrainosus, also known as Status Migraine, Intractable Migraine and Pernicious Migraine is defined as a severe migraine headache without aura, lasting longer than 72 hours and is classified as a complication of a migraine. There are about 100 million people with headaches in the U.Cervical spine disorder: Cervical Spine Disorders are illnesses that are relatively detrimental to ones physical health. These ailments exist in the cervical spine which is made up of the upper first seven vertebrae, encasing and shielding the Spinal cord.

(1/1047) Energy cost of propulsion in standard and ultralight wheelchairs in people with spinal cord injuries.

BACKGROUND AND PURPOSE: Wheelchair- and subject-related factors influence the efficiency of wheelchair propulsion. The purpose of this study was to compare wheelchair propulsion in ultralight and standard wheelchairs in people with different levels of spinal cord injury. SUBJECTS: Seventy-four subjects (mean age=26.2 years, SD=7.14, range=17-50) with spinal cord injury resulting in motor loss (30 with tetraplegia and 44 with paraplegia) were studied. METHOD: Each subject propelled standard and ultralight wheelchairs around an outdoor track at self-selected speeds, while data were collected at 4 predetermined intervals. Speed, distance traveled, and oxygen cost (VO2 mL/kg/m) were compared by wheelchair, group, and over time, using a Bonferroni correction. RESULTS: In the ultralight wheelchair, speed and distance traveled were greater for both subjects with paraplegia and subjects with tetraplegia, whereas VO2 was less only for subjects with paraplegia. Subjects with paraplegia propelled faster and farther than did subjects with tetraplegia. CONCLUSION AND DISCUSSION: The ultralight wheelchair improved the efficiency of propulsion in the tested subjects. Subjects with tetraplegia, especially at the C6 level, are limited in their ability to propel a wheelchair.  (+info)

(2/1047) Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans.

Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of approximately 1 l/min, heart rate increased from 66 +/- 4 to 86 +/- 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 +/- 3 to 110 +/- 8 beats/min. In contrast, blood pressure increased only in C (from 88 +/- 3 to 99 +/- 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI.  (+info)

(3/1047) Airway hyperresponsiveness to ultrasonically nebulized distilled water in subjects with tetraplegia.

The majority of otherwise healthy subjects with chronic cervical spinal cord injury (SCI) demonstrate airway hyperresponsiveness to aerosolized methacholine or histamine. The present study was performed to determine whether ultrasonically nebulized distilled water (UNDW) induces airway hyperresponsiveness and to further elucidate potential mechanisms in this population. Fifteen subjects with SCI, nine with tetraplegia (C4-7) and six with paraplegia (T9-L1), were initially exposed to UNDW for 30 s; spirometry was performed immediately and again 2 min after exposure. The challenge continued by progressively increasing exposure time until the forced expiratory volume in 1 s decreased 20% or more from baseline (PD20) or the maximal exposure time was reached. Five subjects responding to UNDW returned for a second challenge 30 min after inhalation of aerosolized ipratropium bromide (2.5 ml of a 0.6% solution). Eight of nine subjects with tetraplegia had significant bronchoconstrictor responses to UNDW (geometric mean PD20 = 7.76 +/- 7.67 ml), whereas none with paraplegia demonstrated a response (geometric mean PD20 = 24 ml). Five of the subjects with tetraplegia who initially responded to distilled water (geometric mean PD20 = 5.99 +/- 4.47 ml) were not responsive after pretreatment with ipratropium bromide (geometric mean PD20 = 24 ml). Findings that subjects with tetraplegia are hyperreactive to UNDW, a physicochemical agent, combined with previous observations of hyperreactivity to methacholine and histamine, suggest that overall airway hyperresponsiveness in these individuals is a nonspecific phenomenon similar to that observed in patients with asthma. The ability of ipratropium bromide to completely block UNDW-induced bronchoconstriction suggests that, in part, airway hyperresponsiveness in subjects with tetraplegia represents unopposed parasympathetic activity.  (+info)

(4/1047) Anaesthetic management of a woman who became paraplegic at 22 weeks' gestation after a spontaneous spinal cord haemorrhage secondary to a presumed arteriovenous malformation.

A 19-yr-old woman developed a paraplegia with a T10 sensory level at 22 weeks' gestation. The spinal injury was caused by spontaneous bleed of a presumed arteriovenous malformation in the spinal cord. She presented for Caesarean section at term because of the breech position of her fetus. The successful use of a combined spinal epidural-regional anaesthetic is described and the risks of general and regional anaesthesia are discussed.  (+info)

(5/1047) Occurrence of familial spastic paraplegia in only one of monozygous twins.

Three patients who suffer from spastic paraplegia are described who belong to two generations in one family. One of the patients, who has had symptoms and signs for at least 10 years, has a monozygous twin who is unaffected. Using blood groups and chromosomal polymorphisms, the probability of monozygosity is estimated to be 0.99986. The observation of nonpenetrance in familial spastic paraplegia suggests that environmental factors may be involved in provocation and emphasises the need for careful genetic counselling in this and related diseases.  (+info)

(6/1047) Neurotoxic effects of 2,5-hexanedione on normal and neurofilament-deficient quail.

The neurotoxic effects of 2,5-hexanedione (2,5-HD) were investigated using neurofilament (NF)-deficient (Quv) Japanese quail in comparison with normal Japanese quail. Both Quv and normal Japanese quail were inoculated intraperitoneally with 350 mg/kg/day 2,5-HD for 6 consecutive wk. The results of 2,5-HD exposure differed substantially between the 2 strains of Japanese quail. The 2,5-HD-exposed normal quail showed leg paralysis about 4 wk after initiation of dosing. Some treated normal quail fell into dysstasia and died of nutritional disturbances. Histologically, 2,5-HD-treated normal quail had NF-rich axonal swellings and degeneration in the distal parts of the peripheral nerves, spinal cord, and cerebellar peduncles. In contrast, 2,5-HD-injected Quv quail showed tonic convulsion, ataxia gait, severe quivering, and excitation about 2-3 days after administration. Some treated Quv birds died immediately after systemic tonic convulsion, probably because of asphyxia. Although all treated Quv quail showed neurologic signs, there were no recognizable 2,5-HD-induced lesions in the nervous system. After about 4-6 wk of dosing, 2,5-HD induced distal axonopathy in normal quail and acute neurotoxicity in Quv quail.  (+info)

(7/1047) Triplet pregnancy achieved through intracytoplasmic sperm injection with spermatozoa obtained by prostatic massage of a paraplegic patient: case report.

Spinal cord-injured men with ejaculation disorders can have children thanks to assisted reproduction techniques. Spermatozoa from these patients are usually obtained through vibratory stimulation, electroejaculation or by puncturing the seminal duct or the testicle. We present the first published case, as far as we are aware, of spermatozoa obtained through prostatic massage of a paraplegic patient. Penile vibratory stimulation was unsuccessful in this patient. In-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) with spermatozoa obtained through electroejaculation was performed at another centre but pregnancy was not achieved. Through prostatic massage, we obtained a total semen volume of 6 ml containing a total count of 12.32x10(6) spermatozoa (6.24x10(6) with tails), 8% of which had motility (graded + and ++); and 16% of which had normal morphology. The spermatozoa obtained were then used to perform IVF with ICSI and a triplet pregnancy was achieved. Prostatic massage appears to be an easy, non-traumatic and risk-free method to obtain spermatozoa from paraplegic patients.  (+info)

(8/1047) Pregnancy of the wife of a complete paraplegic by homologeous insemination after an intrathecal injection of neostigmine.

A case of successful pregnancy following artificial insemination following intrathecal neostigmine injection in the wife of a complete traumatic paraplegic (T7-T8 to T11-T12) is described.  (+info)

hereditary spastic pa

  • Our objective was to estimate the frequency as well as to establish the clinical and neuroimaging profile of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). (
  • Spastic paraplegia type 8 is a pure hereditary spastic paraplegia. (
  • Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q. (


  • These disorders are characterized by progressive muscle stiffness (spasticity) and the development of paralysis of the lower limbs (paraplegia). (
  • Like all hereditary spastic paraplegias, spastic paraplegia type 8 involves spasticity of the leg muscles and muscle weakness. (
  • Some people with paraplegia also have something called spasticity which is an increase in muscle tone that can cause stiffness and spasms in the legs. (


  • Paraplegia is paralysis of the legs (no movement or feeling). (
  • Paraplegia = weakness or paralysis of the 2 lower extremities. (


  • The signs and symptoms of spastic paraplegia type 8 usually appear in early to mid-adulthood. (
  • What are the symptoms associated with paraplegia? (


  • Some disabilities, such as some types of spinal cord injuries that cause paraplegia or quadriplegia , are associated with a progressive degenerative course that truncates worklife expectancy. (
  • What's the main difference between paraplegia and quadriplegia, if any? (
  • Paraplegia is often not associated with mental retardation or epilepsy , while quadriplegia is almost always associated with both. (
  • Whats the different between paraplegia and quadriplegia? (


  • Spastic paraplegia type 8 is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (


  • People with paraplegia face difficulties with mobility and often need wheelchairs to get around. (