An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
A genus of Eurasian herbaceous plants, the poppies (family PAPAVERACEAE of the dicotyledon class Magnoliopsida), that yield OPIUM from the latex of the unripe seed pods.
Drugs used to cause dilation of the blood vessels.
A drug that is derived from opium, which contains from 0.3-1.5% thebaine depending on its origin. It produces strychnine-like convulsions rather than narcosis. It may be habit-forming and is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). (From Merck Index, 11th ed)
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
The interactions between physician and patient.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Use of plants or herbs to treat diseases or to alleviate pain.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The term "United States" in a medical context often refers to the country where a patient or study participant resides, and is not a medical term per se, but relevant for epidemiological studies, healthcare policies, and understanding differences in disease prevalence, treatment patterns, and health outcomes across various geographic locations.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Dynamic response of the intracranial system in the conscious dog to papaverine hydrochloride. (1/447)

The influence of papaverine on the intracranial system of the dog was studied by measuring the pressure-depth-time response for the intact intracranial system, i.e., for the subarachnoid and subpial compartments. This was accomplished by a measurement system which provided an accurate pressure-depth determination and a uniform rate of transducer insertion. Distinct regions of the intracranial system (subarachnoid, transitional, and subpial) were identified from inflections in the pressure response curve. The test parameter, brain relative stiffness (BRS), was obtained by determining the slope of the pressure response values within the subpial region. This parameter is a measure of the "stiffness" or elasticity of bring tissue within the test configuration. A bolus injection of papaverine (1 mg per kilogram, i.v.) caused an increase in the transitional region, a compensatory reduction in the subarachnoid space, and an increase in BRS. It is postulated that at normotensive arterial blood pressure, cerebrovascular expansion caused by papaverine resulted in increased brain tissue elasticity, i.e., an increase in the pressure-depth response for the subpial region. Possible implications for this increase are discussed. Experiments should be conducted in which local blood flow studies are coupled with measurements of brain elastic response.  (+info)

Mediation of humoral catecholamine secretion by the renin-angiotensin system in hypotensive rainbow trout (Oncorhynchus mykiss). (2/447)

The individual contributions of, and potential interactions between, the renin-angiotensin system (RAS) and the humoral adrenergic stress response to blood pressure regulation were examined in rainbow trout. Intravenous injection of the smooth muscle relaxant, papaverine (10 mg/kg), elicited a transient decrease in dorsal aortic blood pressure (PDA) and systemic vascular resistance (RS), and significant increases in plasma angiotensin II (Ang II) and catecholamine concentrations. Blockade of alpha-adrenoceptors before papaverine treatment prevented PDA and RS recovery, had no effect on the increase in plasma catecholamines, and resulted in greater plasma Ang II concentrations. Administration of the angiotensin-converting enzyme inhibitor, lisinopril (10(-4) mol/kg), before papaverine treatment attenuated the increases in the plasma concentrations of Ang II, adrenaline, and noradrenaline by 90, 79, and 40%, respectively and also prevented PDA and RS recovery. By itself, lisinopril treatment caused a gradual and sustained decrease in PDA and RS, and reductions in basal plasma Ang II and adrenaline concentrations. Bolus injection of a catecholamine cocktail (4 nmol/kg noradrenaline plus 40 nmol/kg adrenaline) in the lisinopril+papaverine-treated trout, to supplement their circulating catecholamine concentrations and mimic those observed in fish treated only with papaverine, resulted in a temporary recovery in PDA and RS. These results indicate that the RAS and the acute humoral adrenergic response are both recruited during an acute hypotensive stress, and have important roles in the compensatory response to hypotension in rainbow trout. However, whereas the contribution of the RAS to PDA recovery is largely indirect and relies on an Ang II-mediated secretion of catecholamines, the contribution from the adrenergic system is direct and relies at least in part on plasma catecholamines.  (+info)

Agonist-specific impairment of coronary vascular function in genetically altered, hyperlipidemic mice. (3/447)

The objectives of the present study were to 1) examine mechanisms involved in endothelium-dependent responses of coronary arteries from normal mice and 2) determine whether vascular responses of coronary arteries are altered in two genetic models of hypercholesterolemia [apolipoprotein E (apoE)-deficient mice (apoE -/-) and combined apoE and low-density lipoprotein receptor (LDLR)-deficient mice (apoE + LDLR -/-)]. Plasma cholesterol levels were higher in both apoE -/- and apoE + LDLR -/- compared with normal mice on normal and high-cholesterol diets (normal chow: normal 110 +/- 5 mg/dl, apoE -/- 680 +/- 40 mg/dl, apoE + LDLR -/- 810 +/- 40 mg/dl; high-cholesterol chow: normal 280 +/- 60 mg/dl, apoE -/- 2,490 +/- 310 mg/dl, apoE + LDLR -/- 3,660 +/- 290 mg/dl). Coronary arteries from normal (C57BL/6J), apoE -/-, and apoE + LDLR -/- mice were isolated and cannulated, and diameters were measured using videomicroscopy. In normal mice, vasodilation in response to ACh and serotonin was markedly reduced by 10 microM Nomega-nitro-L-arginine (an inhibitor of nitric oxide synthase) or 20 microM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; an inhibitor of soluble guanylate cyclase). Vasodilation to nitroprusside, but not papaverine, was also inhibited by ODQ. Dilation of arteries from apoE -/- and apoE + LDLR -/- mice on normal diet in response to ACh was similar to that observed in normal mice. In contrast, dilation of arteries in response to serotonin from apoE -/- and apoE + LDLR -/- mice was impaired compared with normal. In arteries from both apoE -/- and apoE + LDLR -/- mice on high-cholesterol diet, dilation to ACh was decreased. In apoE + LDLR -/- mice on high-cholesterol diet, dilation of coronary arteries to nitroprusside was increased. These findings suggest that dilation of coronary arteries from normal mice in response to ACh and serotonin is dependent on production of nitric oxide and activation of soluble guanylate cyclase. Hypercholesterolemia selectively impairs dilator responses of mouse coronary arteries to serotonin. In the absence of both apoE and the LDL receptor, high levels of cholesterol result in a greater impairment in coronary endothelial function.  (+info)

Inhibitory effect of 4-aminopyridine on responses of the basilar artery to nitric oxide. (4/447)

1. Voltage-dependent K+ channels are present in cerebral arteries and may modulate vascular tone. We used 200 microM 4-aminopyridine (4-AP), thought to be a relatively selective inhibitor of voltage-dependent K+ channels at this concentration, to test whether activation of these channels may influence baseline diameter of the basilar artery and dilator responses to nitric oxide (NO) and cyclic GMP in vivo. 2. Using a cranial window in anaesthetized rats, topical application of 4-AP to the basilar artery (baseline diameter = 240+/-5 microm, mean +/- s.e.mean) produced 10+/-1% constriction. Sodium nitroprusside (a NO donor), acetylcholine (which stimulates endothelial release of NO), 8-bromo cyclic GMP (a cyclic GMP analogue), cromakalim (an activator of ATP-sensitive K+ channels) and papaverine (a non-NO, non-K+ channel-related vasodilator) produced concentration-dependent vasodilator responses that were reproducible. 3. Responses to 10 and 100 nM nitroprusside were inhibited by 4-AP (20+/-4 vs 8+/-2% and 51+/-5 vs 33+/-5%, respectively, n=10; P<0.05). Responses to acetylcholine and 8-bromo cyclic GMP were also partially inhibited by 4-AP. In contrast, 4-AP had no effect on vasodilator responses to cromakalim or papaverine. These findings suggest that NO/cyclic GMP-induced dilator responses of the basilar artery are selectively inhibited by 4-aminopyridine. 4. Responses to nitroprusside were also markedly inhibited by 10 microM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (an inhibitor of soluble guanylate cyclase; 16+/-4 vs 1+/-1% and 44+/-7 vs 7+/-1%; n=10; P<0.05). 5. Thus, dilator responses of the rat basilar artery to NO appear to be mediated by activation of soluble guanylate cyclase and partially by activation of a 4-aminopyridine-sensitive mechanism. The most likely mechanism would appear to be activation of voltage-dependent K+ channels by NO/cyclic GMP.  (+info)

Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm. (5/447)

We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere (Lipo-PGE1) in relation with transcranial Doppler parameters such as mean flow velocity (MFV) and pulsatile index (PI) of the proximal segment of the middle cerebral artery. Eighty patients with subarachnoid hemorrhage (SAH) were included in this study. In the case of angiographic vasospasm, papaverine at 7 mg/min with total dose below 300 mg per artery and 10-20 micrograms of Lipo-PGE1 were injected in the supraclinoid portion of the internal carotid artery. Vasospasm was improved in 24 patients (63%), however, it was unchanged in 14 patients (37%). The former patients had more favorable outcomes than the latter patients (p < 0.005). After intracarotid injection therapy, the correlation between MFV and PI was classified into three types: type 1, both MFV and PI decreased; type 2, MFV decreased but PI increased; and type 3, both MFV and PI fluctuated. The Glasgow Outcome Scale 3 months after SAH was as follows: type 1 (n = 15), good in 14 (93%) and moderate disability in one (7%); type 2 (n = 9), good in eight (89%) and vegetative state in one (11%); and type 3 (n = 14), moderate disability in five (36%), severe disability in seven (50%), and death in two (14%). Chi-square analysis showed significant differences between type 1 and type 3 (p < 0.005), and type 2 and type 3 (p < 0.005). In conclusion, intracarotid papaverine combined with Lipo-PGE1 was effective for vasospasm but type 3 patients require a different treatment protocol.  (+info)

A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. (6/447)

In this report, we deal with the isolation of a novel vasorelaxing peptide from a chymotryptic digest of ovalbumin and its vasorelaxing activities. This peptide is composed of Arg-Ala-Asp-His-Pro-Phe (RADHPF) in its sequence, corresponding to residues 359-364 of ovalbumin. This peptide (30-300 microM) exerted a dose-dependent vasodilation in an isolated mesenteric artery from a spontaneously hypertensive rat which was pre-constricted by phenylephrine, besides the relaxation being endothelium-dependent. It is noteworthy that the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester inhibited this relaxation, implying involvement of nitric oxide in its mechanism of action. Following oral administration of RADHPF at a dose of 10 mg/kg, the systolic blood pressure in a spontaneously hypertensive rat was significantly lowered.  (+info)

Pulmonary artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension. (7/447)

Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent [sodium nitroprusside (SNP), papaverine (PPV)] vasodilators were compared in preconstricted pulmonary artery (PA) rings from these chicken strains. ACh (10(-7), 10(-6), and 10(-5) M)- and A23187 (10(-6) and 10(-5.5) M)-induced relaxations were smaller (P < 0.05) in broilers than Leghorns. N(G)-nitro-L-arginine methyl ester (10(-3.5) M) caused similar reductions in ACh-induced relaxations in both strains. L-Arginine (10(-4) M) enhanced ACh-induced relaxations more in broilers than Leghorns. Relaxations to 10(-10)-10(-6) M SNP did not differ between strains, but were greater (P < 0.05) in broilers than Leghorns at higher concentrations (10(-5) and 10(-4) M). PPV (10(-4) M)- and SNP (10(-4) M)-induced maximal relaxations were greater in broilers than in Leghorns (176.2 +/- 14.7 vs. 120.9 +/- 14.7% and 201.3 +/- 7.8 vs. 171.2 +/- 10.7%, respectively, P < 0.05). Broiler PA rings appear to have increased intrinsic tone and reduced endothelium-derived nitric oxide activity, both of which may contribute to the susceptibility of broiler chickens to pulmonary hypertension.  (+info)

Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway. (8/447)

OBJECTIVE: A reduced bioactivity of endothelial nitric oxide (NO) has been implicated in the pathogenesis of atherosclerosis. In humans, the endothelial L-arginine-NO pathway has been indirectly assessed via the flow response to endothelium-dependent vasodilators locally administered into the coronary, pulmonary or forearm circulation. However, biochemical quantification of endothelial NO formation in these organ circulations has been hampered so far because of the rapid metabolism of NO. Therefore, we aimed to work out a reliable biochemical index to assess endothelial NO formation in human circulation. METHODS: In 33 healthy volunteers, forearm blood flow (FBF) was measured by standard techniques of venous occlusion plethysmography at rest, after local application of the endothelium-dependent vasodilator acetylcholine (ACH), the endothelium-independent vasodilator papaverine (PAP), the stereospecific inhibitor of endothelial NO synthase (eNOS) L-NMMA, and L-arginine (ARG), the natural substrate of eNOS. In parallel, nitrite and nitrate concentrations in blood samples taken from the antecubital vein were measured by HPLC using anion-exchange chromatography in combination with electrochemical and ultraviolet detection following a specific sample preparation method. RESULTS: ACH dose-dependently increased resting FBF (from 3.0 +/- 0.3 to 10.4 +/- 0.9 ml/min per 100 ml tissue) and serum nitrite concentration (from 402 +/- 59 to 977 +/- 82 nmol/l, both p < 0.05, n = 12). A significant correlation was observed between the changes in FBF and the serum nitrite concentration (r = 0.61, p < 0.0001). L-NMMA reduced resting FBF and endothelium-dependent vasodilation by 30% and this was paralleled by a significant reduction in serum nitrite concentration at the highest dose of ACH (n = 9, p < 0.001). PAP increased FBF more than fourfold, but did not affect serum nitrite concentration (n = 11), whereas ARG significantly increased both FBF and nitrite. Basal serum nitrate amounted to 25 +/- 4 mumol/l and remained constant during the application of ACH, PAP and L-NMMA. CONCLUSIONS: The concentration of serum nitrite sensitively reflects changes in endothelial NO formation in human forearm circulation. This biochemical measure may help to characterize the L-arginine-NO pathway in disease states associated with endothelial dysfunction and to further elucidate its pathophysiological significance for the development of atherosclerosis in humans.  (+info)

Papaverine is defined as a smooth muscle relaxant and a non-narcotic alkaloid derived from the opium poppy. It works by blocking the phosphodiesterase enzyme, leading to an increase in cyclic adenosine monophosphate (cAMP) levels within the cells, which in turn results in muscle relaxation.

It is used medically for its vasodilatory effects to treat conditions such as cerebral or peripheral vascular spasms and occlusive diseases, Raynaud's phenomenon, and priapism. Papaverine can also be used as an anti-arrhythmic agent in the management of certain types of cardiac arrhythmias.

It is important to note that papaverine has a narrow therapeutic index, and its use should be closely monitored due to the potential for adverse effects such as hypotension, reflex tachycardia, and gastrointestinal disturbances.

"Papaver" is the genus name for the poppy plant family, which includes several species of plants that are known for their showy flowers and often contain medicinal alkaloids. The most well-known member of this family is probably Papaver somniferum, also known as the opium poppy. This particular species contains a number of pharmacologically active compounds, including morphine, codeine, and papaverine, which have been used in various medical contexts for their analgesic, sedative, and vasodilatory effects. However, it's worth noting that the use of Papaver somniferum and its derivatives is tightly regulated due to their potential for abuse and addiction.

Vasodilator agents are pharmacological substances that cause the relaxation or widening of blood vessels by relaxing the smooth muscle in the vessel walls. This results in an increase in the diameter of the blood vessels, which decreases vascular resistance and ultimately reduces blood pressure. Vasodilators can be further classified based on their site of action:

1. Systemic vasodilators: These agents cause a generalized relaxation of the smooth muscle in the walls of both arteries and veins, resulting in a decrease in peripheral vascular resistance and preload (the volume of blood returning to the heart). Examples include nitroglycerin, hydralazine, and calcium channel blockers.
2. Arterial vasodilators: These agents primarily affect the smooth muscle in arterial vessel walls, leading to a reduction in afterload (the pressure against which the heart pumps blood). Examples include angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and direct vasodilators like sodium nitroprusside.
3. Venous vasodilators: These agents primarily affect the smooth muscle in venous vessel walls, increasing venous capacitance and reducing preload. Examples include nitroglycerin and other organic nitrates.

Vasodilator agents are used to treat various cardiovascular conditions such as hypertension, heart failure, angina, and pulmonary arterial hypertension. It is essential to monitor their use carefully, as excessive vasodilation can lead to orthostatic hypotension, reflex tachycardia, or fluid retention.

Thebaine is a naturally occurring alkaloid found in the opium poppy (Papaver somniferum) and is defined medically as follows:

A benzylisoquinoline alkaloid, Thebaine is a potent opioid agonist with complex pharmacology. It acts as an antagonist at mu and delta receptors while exhibiting agonist activity at kappa receptors. Due to its strong physiological effects and potential for abuse, thebaine has limited therapeutic use. However, it serves as a crucial intermediate in the semi-synthesis of various opioid analgesics, such as oxycodone, hydrocodone, and nalbuphine.

Please note that this definition is intended for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment.

Penile erection is a physiological response that involves the engagement of the corpus cavernosum and spongiosum (erectile tissue) of the penis with blood, leading to its stiffness and rigidity. This process is primarily regulated by the autonomic nervous system and is influenced by factors such as sexual arousal, emotional state, and certain medications or medical conditions. A penile erection may also occur in non-sexual situations, such as during sleep (nocturnal penile tumescence) or due to other physical stimuli.

Phosphodiesterase inhibitors (PDE inhibitors) are a class of drugs that work by blocking the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), two crucial intracellular signaling molecules.

By inhibiting these enzymes, PDE inhibitors increase the concentration of cAMP and cGMP in the cells, leading to a variety of effects depending on the specific type of PDE enzyme that is inhibited. These drugs have been used in the treatment of various medical conditions such as erectile dysfunction, pulmonary arterial hypertension, and heart failure.

Examples of PDE inhibitors include sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) for erectile dysfunction, and iloprost, treprostinil, and sildenafil for pulmonary arterial hypertension. It's important to note that different PDE inhibitors have varying levels of selectivity for specific PDE isoforms, which can result in different therapeutic effects and side effect profiles.

Chlorobutanol is a chemical compound that is used primarily as a preservative in pharmaceutical and cosmetic products. It is an organic compound that belongs to the class of compounds known as halogenated hydrocarbons, which contain one or more halogens (such as chlorine, fluorine, bromine, or iodine) and hydrogen atoms bonded to a carbon skeleton.

In medical terms, Chlorobutanol is used as an antimicrobial agent, which means it helps to prevent the growth of bacteria, fungi, and other microorganisms in products such as eye drops, nasal sprays, and injectable medications. It works by denaturing proteins in microorganisms, which makes it difficult for them to survive and multiply.

It is important to note that Chlorobutanol can be harmful if ingested or absorbed through the skin in large quantities, so it should be used with caution and only under the direction of a healthcare professional.

Intracranial vasospasm is a medical condition characterized by the narrowing or constriction of the intracranial arteries, which are the blood vessels that supply blood to the brain. This narrowing is usually caused by the contraction or spasming of the smooth muscle in the walls of the arteries, leading to reduced blood flow and oxygen delivery to the brain tissue.

Intracranial vasospasm is often associated with subarachnoid hemorrhage (SAH), a type of stroke caused by bleeding in the space surrounding the brain. SAH can cause the release of blood components, such as hemoglobin and iron, which can irritate and damage the walls of the arteries. This irritation can trigger an inflammatory response that leads to the contraction of the smooth muscle in the artery walls, causing vasospasm.

Vasospasm can cause further ischemia (reduced blood flow) or infarction (tissue death) in the brain, leading to serious neurological deficits or even death. Therefore, prompt diagnosis and treatment of intracranial vasospasm are crucial for improving patient outcomes. Treatment options may include medications to dilate the blood vessels, angioplasty (balloon dilation) or stenting procedures to mechanically open up the arteries, or surgical intervention to relieve pressure on the brain.

"Pharmaceutical solutions" is a term that refers to medications or drugs that are formulated in a liquid state, as opposed to solid forms like tablets or capsules. These solutions are typically created by dissolving the active pharmaceutical ingredient (API) in a solvent, such as water or ethanol, along with other excipients that help stabilize and preserve the solution.

Pharmaceutical solutions can be administered to patients through various routes, including oral, intravenous, subcutaneous, or intramuscular injection, depending on the desired site of action and the specific properties of the drug. Some examples of pharmaceutical solutions include antibiotic infusions, pain medications, and electrolyte replacement drinks.

It's important to note that the term "pharmaceutical solutions" can also refer more broadly to the process of developing and manufacturing drugs, as well as to the industry as a whole. However, in a medical context, it most commonly refers to liquid medications.

Intra-arterial infusion is a medical procedure in which a liquid medication or fluid is delivered directly into an artery. This technique is used to deliver drugs directly to a specific organ or region of the body, bypassing the usual systemic circulation and allowing for higher concentrations of the drug to reach the target area. It is often used in cancer treatment to deliver chemotherapeutic agents directly to tumors, as well as in other conditions such as severe infections or inflammation.

Intra-arterial infusions are typically administered through a catheter that is inserted into an artery, usually under the guidance of imaging techniques such as fluoroscopy, CT, or MRI. The procedure requires careful monitoring and precise control to ensure proper placement of the catheter and accurate delivery of the medication.

It's important to note that intra-arterial infusions are different from intra venous (IV) infusions, where medications are delivered into a vein instead of an artery. The choice between intra-arterial and intra-venous infusion depends on various factors such as the type of medication being used, the location of the target area, and the patient's overall medical condition.

Opium is defined as the dried latex obtained from incisions made in the unripe seedpods of the opium poppy (Papaver somniferum). It contains a number of alkaloids, including morphine, codeine, and thebaine. Opium has been used for its pain-relieving, euphoric, and sedative effects since ancient times. However, its use is highly regulated due to the risk of addiction and other serious side effects.

Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It can have physical and psychological causes, such as underlying health conditions like diabetes, heart disease, obesity, and mental health issues like stress, anxiety, and depression. ED can also be a side effect of certain medications. Treatment options include lifestyle changes, medication, counseling, and in some cases, surgery.

The penis is a part of the male reproductive and urinary systems. It has three parts: the root, the body, and the glans. The root attaches to the pelvic bone and the body makes up the majority of the free-hanging portion. The glans is the cone-shaped end that protects the urethra, the tube inside the penis that carries urine from the bladder and semen from the testicles.

The penis has a dual function - it acts as a conduit for both urine and semen. During sexual arousal, the penis becomes erect when blood fills two chambers inside its shaft. This process is facilitated by the relaxation of the smooth muscles in the arterial walls and the trappping of blood in the corpora cavernosa. The stiffness of the penis enables sexual intercourse. After ejaculation, or when the sexual arousal passes, the muscles contract and the blood flows out of the penis back into the body, causing it to become flaccid again.

The foreskin, a layer of skin that covers the glans, is sometimes removed in a procedure called circumcision. Circumcision is often performed for religious or cultural reasons, or as a matter of family custom. In some countries, it's also done for medical reasons, such as to treat conditions like phimosis (an inability to retract the foreskin) or balanitis (inflammation of the glans).

It's important to note that any changes in appearance, size, or function of the penis should be evaluated by a healthcare professional, as they could indicate an underlying medical condition.

Parasympatholytics are a type of medication that blocks the action of the parasympathetic nervous system. The parasympathetic nervous system is responsible for the body's rest and digest response, which includes slowing the heart rate, increasing intestinal and glandular activity, and promoting urination and defecation.

Parasympatholytics work by selectively binding to muscarinic receptors, which are found in various organs throughout the body, including the heart, lungs, and digestive system. By blocking these receptors, parasympatholytics can cause a range of effects, such as an increased heart rate, decreased glandular secretions, and reduced intestinal motility.

Some common examples of parasympatholytics include atropine, scopolamine, and ipratropium. These medications are often used to treat conditions such as bradycardia (slow heart rate), excessive salivation, and gastrointestinal cramping or diarrhea. However, because they can have significant side effects, parasympatholytics are typically used only when necessary and under the close supervision of a healthcare provider.

Cinnarizine is an antihistamine and calcium channel blocker medication that is primarily used to treat motion sickness and vertigo. It works by blocking histamine H1 receptors in the brain, which helps to reduce the symptoms of motion sickness such as nausea and vomiting. Additionally, cinnarizine can also help to improve blood flow to the inner ear, which may help to alleviate symptoms of vertigo and dizziness.

Cinnarizine is available in various forms, including tablets and syrup, and is typically taken two to three times a day. Common side effects of cinnarizine include drowsiness, dry mouth, and stomach upset. It is important to follow the dosage instructions provided by your healthcare provider, as taking too much cinnarizine can increase the risk of side effects.

It's worth noting that cinnarizine is not approved for use in the United States, but it is available in other countries around the world. As with any medication, it's important to consult with your healthcare provider before taking cinnarizine or any other new medication.

Capillary electrochromatography (CEC) is a separation technique that combines the principles of capillary electrophoresis and high-performance liquid chromatography (HPLC). In CEC, an electric field is applied to a liquid flowing through a narrow fused-silica capillary tube packed with a stationary phase.

The analytes (the substances being separated) are carried by the electroosmotic flow of the liquid and interact with the stationary phase as they migrate through the capillary, resulting in separation based on both charge and size/hydrophobicity. CEC offers high efficiency, resolution, and sensitivity for the separation of a wide range of analytes, including small molecules, peptides, proteins, and nucleic acids.

The medical definition of Capillary Electrochromatography is not commonly used as it is primarily employed in research settings for the analysis of various biological samples, pharmaceuticals, and environmental pollutants.

Theophylline is a medication that belongs to a class of drugs called methylxanthines. It is used in the management of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and other conditions that cause narrowing of the airways in the lungs.

Theophylline works by relaxing the smooth muscle around the airways, which helps to open them up and make breathing easier. It also acts as a bronchodilator, increasing the flow of air into and out of the lungs. Additionally, theophylline has anti-inflammatory effects that can help reduce swelling in the airways and relieve symptoms such as coughing, wheezing, and shortness of breath.

Theophylline is available in various forms, including tablets, capsules, and liquid solutions. It is important to take this medication exactly as prescribed by a healthcare provider, as the dosage may vary depending on individual factors such as age, weight, and liver function. Regular monitoring of blood levels of theophylline is also necessary to ensure safe and effective use of the medication.

Physician-patient relations, also known as doctor-patient relationships, refer to the interaction and communication between healthcare professionals and their patients. This relationship is founded on trust, respect, and understanding, with the physician providing medical care and treatment based on the patient's needs and best interests. Effective physician-patient relations involve clear communication, informed consent, shared decision-making, and confidentiality. A positive and collaborative relationship can lead to better health outcomes, improved patient satisfaction, and increased adherence to treatment plans.

The United States Food and Drug Administration (FDA) is a federal government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our country's food supply, cosmetics, and products that emit radiation. The FDA also provides guidance on the proper use of these products, and enforces laws and regulations related to them. It is part of the Department of Health and Human Services (HHS).

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.

Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.

It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.

I'm sorry for any confusion, but "United States" is a geopolitical entity, specifically the name of the country consisting of 50 states, and it is not a medical term or concept. Therefore, I can't provide a medical definition for it. If you have any questions related to health, medicine, or biology, I would be happy to try to help answer those!

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

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Papaverine. (+)-Reticulin (+)-Laudanosine Papaverine has vasodilator and muscle relaxant properties. Laudanosine acts as a ... Among the known individual substances in this group are papaverine. Additional examples of compounds in this group are the ...
Papaverine Cohen, Pieter A.; Travis, John C.; Keizers, Peter H. J.; Boyer, Frederick E.; Venhuis, Bastiaan J. (6 September 2018 ...
The following Bischler-Napieralski reaction produces papaverine. The Pictet-Gams reaction and the Pictet-Spengler reaction are ... 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ... papaverine, shown below. Bisbenzylisoquinolinium compounds are compounds similar in structure to tubocurarine. They have two ...
Papaverine is a smooth muscle relaxant that acts by increasing blood flow to the penis. Phentolamine is an alpha blocker that ... "Alprostadil / Papaverine / Phentolamine 20mcg-30mg-1mg/ml Injection Solution (Tri-Mix) , Formulas , My Dashboard , Bayview ... Kim ED, el-Rashidy R, McVary KT (February 1995). "Papaverine topical gel for treatment of erectile dysfunction". The Journal of ... Trimix is a prescription combination drug containing alprostadil, papaverine, and phentolamine. It is used to treat erectile ...
... , like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects. Committee for ...
Both species contain morphine and papaverine, powerful opiates. Several other medicinal parallels between the two cultures ...
... but not papaverine and noscapine which have a different mechanism of action Esters of morphine opiates: slightly chemically ... the best example is the smooth-muscle relaxant papaverine. Noscapine is a marginal case as it does have CNS effects but not ...
An example of similar product to Pantopon is Omnopon, which contains morphine, codeine, and papaverine. Pantopon gave its name ... Barlow, O. W. (1932). "The Tranquilizing Potency of Morphine, Pantopon, Codeine, Papaverine and Narcotine". Journal of the ...
Papaverine, an opium alkaloid, has been reported to act as a PDE10 inhibitor. PDE10A is almost exclusively expressed in the ... Inhibitory Mechanism of Papaverine on Carbachol-Induced Contraction in Bovine Trachea; Takeharu Kaneda1,*, Yukako Takeuchi1, ... "Papaverine - induced inhibition of phosphodiesterase activity in various mammalian tissues". Life Sciences. 10 (3): 133-144. ... papaverine". Psychopharmacology. 203 (4): 723-35. doi:10.1007/s00213-008-1419-x. PMC 2748940. PMID 19066855. ...
Some inhibitors include papaverine, PF-2545920, TC-E 5005, and tofisopam. Portal: Biology v t e (Enzymes, All stub articles, ...
Mannhold R (December 1988). "Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine". ...
However, its structural similarity to the non-opioid alkaloid papaverine is notable. Metofoline has around the same efficacy as ... Almorexant Papaverine US patent 3067203, "Tetrahydroisoquinoline Derivatives", issued 1962-12-04, assigned to Hoffmann-La Roche ...
Other contaminants used in urine samples alongside noscapine include papaverine and acetylcodeine. Noscapine is metabolised by ...
Biggs, A.I. (1954). "A spectrophotometric determination of the dissociation constants of p-nitrophenol and papaverine". ...
1989). Self-injection of papaverine and phentolamine in the treatment of psychogenic impotence. Journal of Sex & Marital ... and Marital Impact of Self-Injection of Papaverine and Phentolamine: A Long-Term Prospective Study. Journal of Sex & Marital ...
Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most ... The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and ...
A typical mix might be 30 mg of papaverine, 2 mg of phentolamine, and 20 μg alprostadil. As a generic, it is much less ... The different formulations, including Bimix and Trimix, may include papaverine and/or phentolamine. ...
Other medications may also be administered in this way, including papaverine, phentolamine, and aviptadil. The most common ...
The ingestion of large doses of papaverine in the vegetable Sauropus androgynus has caused it. Additionally, the disorder may ...
... and papaverine which provide pain relief. Opiates activate μ-opioid receptors in the brain which alter the brain's perception ...
... including papaverine). Of these, morphine is the most prevalent comprising 8%-14% of the total. Its effects derive from the ...
With his 9th publication on that topic in 1889, he concluded that the structure of papaverine had been solved. At the ... In the following five years, Goldschmiedt focused on the determination of the structure of papaverine - a compound found in ... His most remarkable results were establishing the structure of several natural compounds including papaverine and ellagic acid ...
Papaverine Noscapine Apomorphine (one additional ring closure) Morphine (two additional ring closures) Berberine (one ... This class is exemplified in part by the following compounds: papaverine, noscapine, codeine, morphine, apomorphine, berberine ...
Animal studies have shown that vasodilators, such as papaverine and isosorbide dinitrate, can be used as antidotes. The animal ...
... papaverine (1814), cocaine (1855), caffeine (1819), quinine (1820), atropine (1831), scopolamine (aka hyoscine, aka laevo- ...
It is a second generation papaverine analog, and was first synthesized around the same time as verapamil. It was first ...
The opium poppy is also the source of medically useful non-analgesic alkaloids, such as papaverine and noscapine.[citation ...
Partial dehydrogenation of laudanosine will lead to papaverine, the alkaloid found in the opium poppy plant (Papaver somniferum ...
... papaverine, shown below. Bischler-Napieralski reaction Pictet-Spengler reaction Pomeranz, C. (December 1893). "Uber eine neue ...
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DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome.
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  • While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine and its derivatives (such as codeine). (wikipedia.org)
  • Papaverine is also present in combinations of opium alkaloid salts such as papaveretum (Omnopon, Pantopon) and others, along with morphine, codeine, and in some cases noscapine and others in a percentage similar to that in opium, or modified for a given application. (wikipedia.org)
  • 3. Determination of morphine, codeine, thebaine, papaverine and narcotine in opium with remission measurement]. (nih.gov)
  • While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic (morphine-related) opium alkaloids (opiates). (israelpharm.com)
  • Morphine is the major opiate, but codeine, thebaine, papaverine and noscapine are also present. (mcgill.ca)
  • Some of the most common and well-known are papaverine, thebaine, morphine, heroin and codeine. (drugnet.net)
  • 11 Ref. HR/TMH Alkaloids Atropine Caffeine Cocaine hydrochloride Codeine Phosphate Diacetylmorphine hydrochloride (heroin) Ephedrine sulfate Lysergide (lysergic acid diethylamide tartrate) Mescaline hydrochloride Morphine sulfate Nicotine salicylate Opium Papaverine Physostigmine salicylate Psilocybin Quinine sulfate Scopolamine hydrobromide Strychnine Yohinbine hydrochloride Compounds that Give Positive Alkaioidal Reaction Lidocaine hydrochloride .Meperidine ( demerol ) Methadone hydrochloride Methaqualone Methylphenidate hydrochloride (talwin. (erowid.org)
  • The opium poppy also gives other alkaloids like codeine, papaverine, and so on. (herbs2000.com)
  • Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of erectile dysfunction and acute mesenteric ischemia. (wikipedia.org)
  • Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. (nih.gov)
  • Papaverine is an alkaloid of the opium group that induces vasodilation of cerebral arteries by inhibiting smooth-muscle contraction. (medscape.com)
  • Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the heart and the brain), and occasionally in the treatment of erectile dysfunction. (israelpharm.com)
  • 3'O-Methyltransferase, Ps3'OMT, from opium poppy: involvement in papaverine biosynthesis. (bvsalud.org)
  • KEY MESSAGE Using, in silico, in vitro and in planta functional assays, we demonstrate that Ps3'OMT, an 3'-O methyl transferase is linked to papaverine biosynthesis in opium poppy . (bvsalud.org)
  • Exporter of a wide range of products which include Papaverine Hydrochloride Injection, Arimidex Anastrozole 1mg Tablet, Alphalan Melphalan 2 Mg Tablets, Sutent 50mg Capsule, Ninedanib Soft Gelatin Capsules150mg and Enzalutamide Capsules 80 mg Glenza 80 mg. (indiamart.com)
  • Papaverine is approved to treat spasms of the gastrointestinal tract, bile ducts and ureter and for use as a cerebral and coronary vasodilator in subarachnoid hemorrhage (combined with balloon angioplasty) and coronary artery bypass surgery. (wikipedia.org)
  • Papaverine is approved to treat spasms. (israelpharm.com)
  • Phentolamine, theophylline, papaverine and methacholine were ineffective. (erowid.org)
  • Medications include prostaglandin E1, papaverine, and phentolamine. (unc.edu)
  • Papaverine is a benzylisoquinoline derivative with direct nonspecific relaxant effect on vascular, cardiac, and other smooth muscle. (medscape.com)
  • Papaverine is a benzylisoquinoline derivative that exerts a direct nonspecific relaxant effect on vascular, cardiac, and other smooth muscle. (medscape.com)
  • Papaverine , one of the benzylisoquinoline alkaloids (BIA) synthesized in the medicinally important plant , Papaver somniferum , is known for the potent pharmacological properties. (bvsalud.org)
  • Papaverine is a myotropic antispasmodic (relieves smooth muscle spasms) drug. (ru-pills.com)
  • Papaverine - used to treat spasms involving the intestines, heart or brain - inhibits a key element of cell DNA within cancerous growths. (asianage.com)
  • Papaverine can be used to treat a number of ailments including heart spasms and erectile dysfunction. (drugnet.net)
  • The venous diameters were measured in all patients who received intraarterial papaverine and/or balloon angioplasty for treatment of vasospasm during the study period of 3 years. (medscape.com)
  • [ 15 ] The successful use of intraarterial papaverine for the treatment of vasospasm has been reported. (medscape.com)
  • Phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine have been advocated as topical antispasmodic agents. (ox.ac.uk)
  • Papaverine had limited antispasmodic efficacy and prevented vasoconstriction in response to potassium (60 mmol/L) and phenylephrine for only 1 hour at the longest. (ox.ac.uk)
  • Papaverine stimulates respiration by acting on carotid and aortic body chemoreceptors. (nih.gov)
  • This action is particularly evident when such vessels are in spasm, induced reflexly or by drugs, and it provides the basis for the clinical use of papaverine in peripheral or pulmonary arterial embolism. (nih.gov)
  • Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting. (ox.ac.uk)
  • METHODS: Isometric tension developed in response to clinically important vasoconstrictors was measured in 100 radial artery rings (from patients undergoing coronary artery bypass grafting, n = 25) after 15 minutes of ex vivo incubation with phenoxybenzamine, verapamil/nitroglycerin solution, papaverine, or vehicle (control). (ox.ac.uk)
  • Papaverine may also be used as a smooth muscle relaxant in microsurgery where it is applied directly to blood vessels. (wikipedia.org)
  • Papaverine Hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL. (nih.gov)
  • Papaverine is a muscle relaxant and this blocks the nerve impulses that are held responsible for contractions. (herbs2000.com)
  • Papaverine relaxes the smooth musculature of the larger blood vessels, including the coronary, cerebral, peripheral, and pulmonary arteries. (nih.gov)
  • Papaverine comes in the form of regular tablets and extended-release capsules. (stason.org)
  • high sensitivity to papaverine. (ru-pills.com)
  • Epithelium removal had no effect on the sensitivity of tracheal strips to papaverine or salbutamol, but significantly enhanced sensitivity to isoproterenol and sodium- nitroprusside. (cdc.gov)
  • Corticosterone pretreatment enhanced tissue sensitivity to isoproterenol but had no effect on tissue responses to either salbutamol or papaverine. (cdc.gov)
  • Papaverine is advocated for the treatment of the widespread vasoconstriction that follows therapy for superior mesenteric artery (SMA) emboli by other modalities. (medscape.com)
  • Pretreatment with topical α-antagonist solutions can inhibit RA vasoconstriction and cause dilatation for a longer period than achieved with papaverine. (bgu.ac.il)
  • Papaverine is also being investigated as a topical growth factor in tissue expansion with some success. (wikipedia.org)
  • tell your doctor and pharmacist if you are allergic to papaverine or any other drugs. (medlineplus.gov)
  • 1. Before you take Papaverine, tell your doctor what prescription and nonprescription drugs you are taking, especially levodopa, and tell your doctor if you have heart disease, glaucoma, or Parkinson's disease. (stason.org)
  • Papaverine is found as a contaminant in some heroin and can be used by forensic laboratories in heroin profiling to identify its source. (wikipedia.org)
  • papaverine, in common with other diuretics, call the pharmacist if you have any questions. (hioctanedesign.com)
  • Frequent side effects of papaverine treatment include polymorphic ventricular tachycardia, constipation, interference with sulphobromophthalein[citation needed] retention test (used to determine hepatic function), increased transaminase levels, increased alkaline phosphatase levels, somnolence, and vertigo. (wikipedia.org)
  • Papaverine, when injected in penile tissue, causes direct smooth muscle relaxation and consequent filling of the corpus cavernosum with blood resulting in erection. (wikipedia.org)
  • Papaverine comes as a tablet and extended-release (long-acting) capsule to take by mouth. (medlineplus.gov)
  • Current intraoperative treatment with papaverine fails to inhibit postoperative RA constriction. (bgu.ac.il)
  • The most characteristic effect of papaverine is relaxation of the tonus of all smooth muscle, especially when it has been spasmodically contracted. (nih.gov)
  • Papaverine is used to improve blood flow in patients with circulation problems. (medlineplus.gov)
  • Papaverine has minimal actions on the central nervous system, although very large doses tend to produce some sedation and sleepiness in some patients. (nih.gov)
  • Forty-three treatments in 26 patients were included: 18 patients (33 territories) were treated with intraarterial papaverine alone, four (four territories) were treated with balloon angioplasty alone, and four (six territories) were treated with both papaverine infusion and angioplasty. (medscape.com)
  • Papaverine is used to improve circulation i.e., blood flow in various parts of the body, including the heart. (stason.org)
  • Papaverine controls high blood pressure but does not cure it. (medlineplus.gov)
  • Comparison of transcript and metabolite profiles of high and low papaverine producing cultivar revealed the occurrence of a 3'O- methyltransferase , Ps3'OMT, which was abundant in aerial organs and shared 72% identity with the GfLOMT7 predicted to have 3'OMT activity. (bvsalud.org)
  • Papaverine is available in its salt form as the hydrochloride, codecarboxylate, adenylate, and teprosylate. (wikipedia.org)
  • The main actions of papaverine are exerted on cardiac and smooth muscle. (nih.gov)
  • Papaverine Hydrochloride apparently acts directly on the muscle itself. (nih.gov)
  • Suppression of Ps3'OMT through virus -induced gene silencing resulted in a remarkable decrease in the level of papaverine in comparison to control plants . (bvsalud.org)
  • If you become pregnant while taking papaverine, call your doctor. (medlineplus.gov)