Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Paget's Disease, Mammary: An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)Paget Disease, Extramammary: A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)Vulvar Neoplasms: Tumors or cancer of the VULVA.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Calcitonin: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.Nipples: The conic organs which usually give outlet to milk from the mammary glands.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC, Inclusion Body: Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)Plicamycin: A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.Bone Resorption: Bone loss due to osteoclastic activity.Scrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Angioid Streaks: Small breaks in the elastin-filled tissue of the retina.Anus Neoplasms: Tumors or cancer of the ANAL CANAL.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Skull Neoplasms: Neoplasms of the bony part of the skull.Genital Neoplasms, Male: Tumor or cancer of the MALE GENITALIA.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Hyperostosis, Cortical, Congenital: A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)Hearing Loss, Conductive: Hearing loss due to interference with the mechanical reception or amplification of sound to the COCHLEA. The interference is in the outer or middle ear involving the EAR CANAL; TYMPANIC MEMBRANE; or EAR OSSICLES.Urogenital Neoplasms: Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.Receptor Activator of Nuclear Factor-kappa B: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)Penile Neoplasms: Cancers or tumors of the PENIS or of its component tissues.Perforator Flap: A mass of tissue for transplantation that includes the skin and/or the SUBCUTANEOUS FAT, and the perforating blood vessel that traverses the underlying tissue to supply blood to the skin. Perforator flaps are named after the anatomical region or muscle from where they are transplanted and/or the perforating blood vessel.Frontotemporal Dementia: The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Presbycusis: Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.Esthetics: The branch of philosophy dealing with the nature of the beautiful. It includes beauty, esthetic experience, esthetic judgment, esthetic aspects of medicine, etc.Humerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Salmon: Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).Desmoplakins: Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Hematoma, Epidural, Cranial: Accumulation of blood in the EPIDURAL SPACE between the SKULL and the DURA MATER, often as a result of bleeding from the MENINGEAL ARTERIES associated with a temporal or parietal bone fracture. Epidural hematoma tends to expand rapidly, compressing the dura and underlying brain. Clinical features may include HEADACHE; VOMITING; HEMIPARESIS; and impaired mental function.Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.Skin Neoplasms: Tumors or cancer of the SKIN.Bone Diseases: Diseases of BONES.Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Audiometry: The testing of the acuity of the sense of hearing to determine the thresholds of the lowest intensity levels at which an individual can hear a set of tones. The frequencies between 125 and 8000 Hz are used to test air conduction thresholds and the frequencies between 250 and 4000 Hz are used to test bone conduction thresholds.Femoral Fractures: Fractures of the femur.Breast Neoplasms: Tumors or cancer of the human BREAST.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

*  Extra-Mammary Paget's Disease with Invasive Adenocarcinoma… | Flickr

Extra-Mammary Paget's Disease with Invasive Adenocarcinoma : Mucicarmine Mucicarmine stain highlights the intraepidermal tumor ...

*  Extra-mammary Paget's disease | Skin Support

What is extra-mammary Paget's disease?. Extra-mammary Paget's disease (EMPD) is a rare, slow-growing disease that is usually ... What does extra-mammary Paget's disease look like?. The rash of EMPD can look like eczema, with red, flaky or sometimes weeping ... This leaflet has been written to help you understand more about extra-mammary Paget's disease. It tells you what it is, what ... Paget's disease, in contrast, refers to the same type of changes affecting the breast or nipple.There is no relation to another ...

*  Complete Resolution of Paget Disease of the Vulva With Imiqu... : Journal of Lower Genital Tract Disease

... is a neoplastic disease of apocrine gland bearing skin. Surgical ... Extra mammary Paget disease (EMPD) is a neoplastic disease of ... Complete Resolution of Paget Disease of the Vulva With Imiquimod Cream Journal of Lower Genital Tract Disease12(2):90-94, April ... Complete Resolution of Paget Disease of the Vulva With Imiquimod Cream. Hatch, Kenneth D. MD; Davis, John R. MD ... Home , April 2008 - Volume 12 - Issue 2 , Complete Resolution of Paget Disease of the Vulva With Imiqu... ...

*  Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors - Full Text View - ClinicalTrials.gov

Breast Diseases. Paget's Disease, Mammary. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... Genetic and Rare Diseases Information Center resources: Paget Disease of the Breast ... Paget's disease, lobular carcinoma in situ (LCIS), or proliferative benign breast disease. ... Paget's disease, lobular carcinoma in situ (LCIS), or proliferative benign breast disease ...

*  Paget's Disease of the Breast | definition of Paget's Disease of the Breast by Medical dictionary

What is Paget's Disease of the Breast? Meaning of Paget's Disease of the Breast medical term. What does Paget's Disease of the ... Looking for online definition of Paget's Disease of the Breast in the Medical Dictionary? Paget's Disease of the Breast ... Paget's disease of the breast may also be called mammary Paget's disease (MPD). There is a much rarer form of this disease ... Paget's Disease of the Breast. Also found in: Wikipedia. Paget's Disease of the Breast. Definition. Paget's disease of the ...
medical-dictionary.thefreedictionary.com/Paget's Disease of the Breast

*  adenoma of the nipple 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Paget's Disease, Mammary / diagnosis. Retrospective Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery ... ABSTRACT Nipple adenoma is a benign condition simulating malignancy such as breast carcinoma and/or Paget's disease clinically. ... Paget's disease).. * Postoperatively, the plasma prolactin level was abnormally high, while the plasma estradiol level was ... consumer health - Breast Diseases.. *[Email] Email this result item Email the results to the following email address: [X] Close ...
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*  Paget Disease: Get Facts on This Rare Cancer of the Nipple

Paget's disease) of the nipple is an uncommon type of cancer that forms around the nipple. It is usually associated with an ... Paget disease of the breast (also known as Paget disease of the nipple and mammary Paget disease) is a rare type of cancer ... including Paget disease of bone and extramammary Paget disease, which includes Paget disease of the vulva and Paget disease of ... These other diseases are not related to Paget disease of the breast. This fact sheet discusses only Paget disease of the breast ...

*  Histopathology - Volume 35, Issue 6 - December 1999 - Wiley Online Library

Morphological evidence for field effect as a mechanism for tumour spread in mammary Paget's disease (pages 567-576). Mai ... Extramammary Paget's disease arising in a mature cystic teratoma of the ovary (pages 582-584). Monteagudo, Torres and Llombart- ...

*  Biopsy, diagnosis and treatment of cysts and tumors sub-cluster 43

Pigmented lesions on the nipple and areola concern patients and physicians as melanoma and pigmented mammary Paget's disease ... Sharma Suraj S Suraj Sharma, Toronto Centre for Liver Disease, Toronto Western Hospital, Toronto, ON M5T 2S8, - - 2014 ... Although pediatric melanoma is a rare disease, diagnosis and management of pigmented lesions in the pediatric population, ... The relationship between the occurrence of skin diseases and skin tattoos remains unclear. Dermatologic disorders have been ...

*  Tissue Diagnosis - Zeta Corporation

Paget Disease: Mammary Paget Disease: Positive for CK7, HER-2/neu, MUC-1, ER. Vulvar and perianal Paget disease: Adnexal tumor ... IgG4-related disease: The diagnosis of IgG4-related disease requires the combination of clinical (autoimmune disease), ... is rarely observed in early disease stages but may be seen as the disease progresses. CD30 may be positive in a subset of early ... Rosai-Dorfman disease: Positive for S-100, CD68 and CD163. CD1a and Langerin are consistently negative. Follicular dendritic ...

*  Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions

Liegl B, Leibl S, Gogg-Kamerer M, Tessaro B, Horn LC, Moinfar F. Mammary and extramammary Paget's disease: an ... Extramammary Paget disease. Paget disease is characterized by a solitary, pruritic (but painless), sharply demarcated, ... The lesion of extramammary Paget disease (EMPD) is clinically indistinguishable from that of Paget disease, except for its ... and MMP-19 are expressed by Paget's cells in extramammary Paget's disease. J Cutan Pathol. Aug 2004. 31(7):483-91. [Medline]. ...

*  Paget Disease of the Breast - National Cancer Institute

... a rare type of cancer that is sometimes called Paget disease of the nipple or mammary Paget disease. ... A fact sheet about Paget disease of the breast, ... What is Paget disease of the breast?. Paget disease of the ... including Paget disease of bone and extramammary Paget disease, which includes Paget disease of the vulva and Paget disease of ... These other diseases are not related to Paget disease of the breast. This fact sheet discusses only Paget disease of the breast ...

*  Paget Disease Imaging: Overview, Radiography, Computed Tomography

Sir James Paget first described Paget disease in 1877 as a chronic inflammatory remodeling disease of bones. ... Paget disease of the bone (osteitis deformans) is a metabolic disorder characterized by abnormal osseous remodeling. ... Rehabilitation for Paget Disease * Paget Disease Imaging * Mammary Paget Disease * Extramammary Paget Disease ... and Paget Disease Imaging What to Read Next on Medscape. Related Conditions and Diseases. * Paget Disease ...

*  Rehabilitation for Paget Disease: Overview, Physical Therapy, Occupational and Speech Therapy

Paget disease is a common disorder in middle-aged and elderly patients that is characterized by excessive and abnormal ... Related Conditions and Diseases. * Paget Disease * Rehabilitation for Paget Disease * Mammary Paget Disease ... Rehabilitation for Paget Disease. Updated: Nov 13, 2013 * Author: David Chow, MD; Chief Editor: Denise I Campagnolo, MD, MS ... Paget disease is a common disorder in middle-aged and elderly patients that is characterized by excessive and abnormal ...

*  Recurrent Extramammary Paget's disease of Axilla: A case report | OGH Reports

Keywords:Axilla, Eczema, Extra-mammary Paget's disease, Malignancy, Recurrence. View:. *PDF (901.92 KB) ... Extramammary Paget's disease of axilla is extremely rare and has not been well reported. It can be confused with eczema, ... Home / OGH Reports, Vol 6, Issue 1, Jan-Jun 2017 / Recurrent Extramammary Paget's disease of Axilla: A case report ... Recurrent Extramammary Paget's disease of Axilla: A case report. *Malik Tariq Rasool, ...

*  Common Practices - tribunedigital-chicagotribune

Was just diagnosed with Paget's disease of the.... September 29, 2000. *Q: Recently I was performing a breast exam when my ... In a culture that erroneously considers our own mammary glands "sexual organs" and the highly processed, overpriced and ...

*  Dermatology Articles (Diagnosis, Dermatologic Surgery, Histology, Prognosis, Follow-up) - Medscape Reference

Mammary Paget Disease. *Microcystic Adnexal Carcinoma. *Nevoid Basal Cell Carcinoma Syndrome. *Premalignant Fibroepithelial ...

*  Mammosite Breast Brachytherapy Optimization in the Treatment of Breast Carcinoma - Full Text View - ClinicalTrials.gov

Paget's disease of the nipple.. *History of invasive breast cancer or DCIS in the same breast. ... infraclavicular or internal mammary nodes, unless biopsy proven to be negative for tumor. ... Gross disease must be unifocal with pathologic (invasive and/or DCIS) tumor size 3 cm or less. (Patients with microscopic ... Patients with a history of non-ipsilateral breast malignancies are eligible if they have been disease-free for 2 or more years ...

*  Medical Information Search (Neoplasms, Multiple Primary)

Paget's Disease, Mammary: An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized ... Genetic Diseases, Inborn. Hamartoma. Neoplasms, Multiple Primary. Skin ... Hamartoma Syndrome, Multiple. Skin Diseases. ... Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under ... A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen ...
https://lookformedical.com/search.php?lang=1&q=Neoplasms, Multiple Primary

*  Dapsone | Skin Support

Extra-mammary Paget's disease. Next section. Back to Conditions A-Z Dapsone. DAPSONE ... The dose of dapsone may need to be lower than usual if you have a heart or lung disease, have a condition called G6PD ...

*  Epidermolysis bullosa simplex | Skin Support

Extra-mammary Paget's disease. Next section. Back to Conditions A-Z Epidermolysis bullosa simplex. EPIDERMOLYSIS BULLOSA ... an affected gene and they will have a one in four chance of having a baby with two affected gene who will then have the disease ...

*  Colchicine | Skin Support

Extra-mammary Paget's disease. Next section. Back to Conditions A-Z Colchicine. COLCHICINE ... Colchicine is used at a lower dose in skin disease when compared with acute gout, but for a longer duration. ... In patients with reduced liver function, heart or gastrointestinal disease, colchicine should be used with caution. ... Overall, with the low doses of colchicine used in skin disease, severe side effects are rare. ...

*  english

Paget Disease, Mammary (0) ...

*  Soon, Oz Women to Get Breast Cancer 'hair X-ray' Test

Pagets disease of the breast. A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, ... Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the mammary gland, Breast ... Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have ... Women and Cancer Breast Biopsy Iodine Deficiency Disorder Pagets disease of the breast Mastitis Cancer and Homeopathy Breast ...

*  Chest X-Rays Could Increase Breast Cancer Risk

Pagets disease of the breast. A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, ... Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the mammary gland, Breast ... Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have ... Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis X-Ray Cancer and Homeopathy Breast Cancer Facts Cancer ...

PagetVulvar intraepithelial neoplasia: (ILDS D07.120) |HydroxyprolineZoledronic acidRisedronic acidProcalcitonin: Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It is composed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine.Nipple adenomaElevated alkaline phosphataseInclusion body myositisDeoxypyridinolineScrotal ligament: The scrotal ligament is actually the remnant of gubernaculum in a fetus. This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis can move within the scrotum.Cancellous bone: Cancellous bone, synonymous with trabecular bone or spongy bone, is one of two types of osseous tissue that form bones. The other osseous tissue type is cortical bone also called compact bone.Anal dysplasia: Anal dysplasia is a pre-cancerous condition which occurs when the lining of the anal canal undergoes abnormal changes. It can be classified as low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL)Cranial vault: The cranial vault is the space in the skull within the neurocranium, occupied by the brain. In humans, the size and shape of the brain, may be affected by the size of the vault as shown in craniometry, but studies relating it to intelligence have found no conclusive evidence.OsteoclastAlendronic acidWorth syndrome: Worth syndrome, also known as benign form of Worth hyperostosis corticalis generalisata with torus platinus, autosomal dominant osteosclerosis, autosomal dominant endosteal hyperostosis or Worth disease, is a rare autosomal dominant congenital disorder that is caused by a mutation in the LRP5 gene. It is characterized by increased bone density and benign bony structures on the palate.Conductive hearing lossClinical Genitourinary Cancer: Clinical Genitourinary Cancer is a peer-reviewed medical journal published by Elsevier, and previously by CIG Media Group (Cancer Information Group). The journal publishes articles on detection, diagnosis, prevention, and treatment of genitourinary cancers.OsteosarcomaIsotopes of calcium: Calcium (Ca) has 24 isotopes, from 34Ca to 57Ca. There are five stable isotopes (40Ca, 42Ca, 43Ca, 44Ca and 46Ca), plus one isotope (48Ca) with such a long half-life that for all practical purposes it can be considered stable.Technetium(IV) chlorideClodronic acidDiseases and parasites in salmonBone tumorEpidural hematomaOsteoprotegerin: Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF), or tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a protein that in humans is encoded by the TNFRSF11B gene. Osteoprotegerin is a cytokine receptor, and a member of the tumor necrosis factor (TNF) receptor superfamily.Bone pathology: Bone pathology, also known as orthopedic pathology is a subspecialty of surgical pathology which deals with the diagnosis and feature of many bone diseases. It uses gross and microscopic findings along with the findings of in vivo radiological studies, and occasionally, specimen radiographs to diagnose diseases of the bones.Femoral fractureBreast cancer classification: Breast cancer classification divides breast cancer into categories according to different schemes, each based on different criteria and serving a different purpose. The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes.Brain biopsyPheophorbidase: Pheophorbidase (, phedase, PPD) is an enzyme with system name pheophorbide-a hydrolase. This enzyme catalyses the following chemical reactionPhotoimmunotherapy: Photoimmunotherapy (PIT) is a new type of molecular targeted cancer therapy, which allows the selective destruction of cancer cells in mice without any damage to normal tissues. It is a light-based cancer therapy, which was developed by Professor Kobayashi and his colleagues at National Cancer Institute, Bethesda, Maryland.

(1/37) 99mTc-MIBI scan in mammary Pagets disease: a case report.

Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased blood flow from angiogenesis and heightened metabolism. We performed a 99mTc-MIBI scan in a patient with mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic image of the uptake from the invasive cancer lesion located deeply in the breast toward the epidermis. 99mTc-MIBI showed an uptake in the deeply located invasive cancer lesion as well as nipple lesion. Especially, the delayed phase of Tc-MIBI scan demonstrated the tumor site more accurately. In conclusion, 99mTc-MIBI scan could be a useful adjunct to clinical decision making in the management of Paget's disease of the breast.  (+info)

(2/37) Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family.

BACKGROUND AND METHODS: In Paget's disease of the breast, the epidermis of the nipple is infiltrated by large neoplastic cells of glandular origin. It has been hypothesized that the spread of Paget cells through the nipple epidermis is induced by a motility factor that acts via the HER2/NEU receptor. To test this hypothesis, we characterized and purified a motility factor released by keratinocytes and identified its target receptors in specimens from patients with Paget's disease and in SK-BR-3 breast adenocarcinoma cells, which overexpress HER2/NEU. RESULTS: We isolated the motility factor from keratinocyte-conditioned medium and sequenced tryptic peptides. These sequences were used to identify the motility factor as heregulin-alpha, which is released by skin keratinocytes. Heregulin-alpha induces spreading, motility, and chemotaxis of SK-BR-3 cells, as does motility factor. Motility factor activities of heregulin-alpha are inhibited by monoclonal antibody AB2, directed against the extracellular domain of HER2/NEU, which blocks the binding of heregulin-alpha. We used in situ hybridization to show that normal epidermal cells produce heregulin-alpha messenger RNA and that heregulin receptors, HER3 and/or HER4, as well as their coreceptor HER2/NEU, are expressed by Paget cells. CONCLUSIONS: Heregulin-alpha is a motility factor that is produced and released by normal epidermal keratinocytes and thus plays a key role in the pathogenesis of Paget's disease. Paget cells express heregulin receptors HER2/NEU, as well as HER3 and/or HER4, both of which function as a co-receptor of HER2/NEU. Binding of heregulin-alpha to the receptor complex on Paget cells results in the chemotaxis of these breast cancer cells, which eventually migrate into the overlying nipple epidermis.  (+info)

(3/37) Mammary and extramammary Paget's disease.

Mammary and extramammary Paget's disease are uncommon intraepithelial adenocarcinomas. Both conditions have similar clinical features, which mimic inflammatory and infective diseases. Histological diagnostic confusion can arise between Paget's disease and other neoplastic conditions affecting the skin, with the most common differential diagnoses being malignant melanoma and atypical squamous disease. The glandular differentiation of both mammary Paget's disease and extramammary Paget's disease is indicated by morphological appearances, the presence of intracellular mucin in many cases, and positive immunohistochemical staining for glandular cytokeratins, epithelial membrane antigen, and carcinoembryonic antigen. This article provides an overview of mammary and extramammary Paget's disease and discusses recent evidence regarding the cell of origin. The concepts of primary and secondary Paget's disease are presented and the differential diagnosis is discussed with reference to immunohistochemical markers that might be of diagnostic value.  (+info)

(4/37) Germline p53 mutation in a patient with multiple primary cancers.

We report a case of multiple primary cancers having a germline missense mutation of the p53 gene. The patient was a Japanese female and had a history of five different types of cancers. PCR/direct sequencing analysis revealed the presence of a nucleotide substitution, AGC (Ser) to AGG (Arg), at codon 106 of the p53 gene in DNA from non-cancerous breast tissue. This is the first case of germline p53 mutation at codon 106, and could contribute to establishing correlations between the types and locations of germline p53 mutations and their phenotypical consequences.  (+info)

(5/37) Her-2/neu gene amplification compared with HER-2/neu protein overexpression on ultrasound guided core-needle biopsy specimens of breast carcinoma.

Genomic amplification and oncoprotein overexpression of Her-2/neu was studied on ultrasound core needle biopsy specimens of the infiltrative ductal carcinomas of the breast. We performed two colour fluorescence in situ hybridization (FISH) for Her-2/neu and chromosome 17 and compared the FISH results with the immunohistochemical overexpression of Her-2/neu protein by 2 antibodies (DAKO HercepTest and the BioGenex monoclonal antibody AM 134-5M). Furthermore, following radical mastectomy with axillary dissection, Her-2/neu status of the patients were compared with the well known histopathological prognostic factors such as histologic grade, tumor stage, lympho/ vascular invasion, surgical margin status and Paget s disease. Amplification was demonstrated 27% of the cases. Her-2/neu protein overexpression was detected in 47% and 80% of the cases with CB11 and HercepTest respectively. We revealed statistically significant association between the tumor, oncoprotein expression and oncogene amplification (p<0.05). The results of our study showed that combination of IHC and FISH methods enhances the evaluation of tumor genetics at both gene and protein level for the analysis of Her-2/neu in breast carcinoma.  (+info)

(6/37) Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?

BACKGROUND: We conducted the present study to determine whether breast cancer morphology is genetically determined. METHODS: Using the nationwide Swedish Family Cancer Database, which includes data on 10.2 million individuals and over 25,000 morphology-specific breast cancers, we followed morphological types in familial cancers between mothers and daughters and between sisters. Additionally, we recorded morphological data in women who presented with two primary breast cancers and in those who presented with an invasive and in situ breast cancer. We used kappa statistics to examine the association between genetics and morphology. A kappa value of 0 indicates that the process is random and a value of 1 indicates that it is completely determined (i.e. genetic); values between 0.40 and 0.60 are considered to indicate a moderately determined process. RESULTS: The study sample included a total of 25,730 first and 3394 second invasive breast cancers, and 2990 in situ breast cancers. Ductal, lobular, tubuloductal and comedo were the most common invasive types. We identified 164 mother-daughter pairs with breast cancer of a defined morphology, yielding a low kappa value of 0.08. Among 100 sister pairs the kappa value was 0.002. In individuals with two primary breast cancers the kappa values were 0.22 and 0.01 for two invasive and in situ-invasive pairs, respectively. However, for a tumour with a subsequent tumour detected in the contralateral breast less than 1 year later the kappa value was 0.47. CONCLUSION: The data suggest that breast cancer morphology is not genetically determined. However, because of mixed morphologies and the overwhelming prevalence of ductal morphology, the results for rare morphologies should be interpreted with caution.  (+info)

(7/37) Paget disease of the nipple: a multifocal manifestation of higher-risk disease.

BACKGROUND: The treatment of Paget disease by mastectomy has been challenged recently in favor of breast-conserving techniques. A large series of patients treated with mastectomy has been reviewed to assess the feasibility of less radical surgery. METHODS: The cases of 70 women with a clinical diagnosis of Paget disease were reviewed. The type, grade, receptor and node status, and the mammographic and pathologic extent of the underlying breast malignancy were determined. The survival of patients with invasive disease was compared with matched controls without Paget disease. RESULTS: The underlying malignancy was invasive in 58% of cases. Despite the fact that only one third of women presented with a palpable mass, the malignancy was frequently extensive, being confined to the retroareolar region in only 25% of cases. The true extent of the disease was underestimated by mammography in 43% of cases. Of the patients with ductal in situ carcinoma, 96.5% had high-grade carcinomas and 100% had invasive carcinomas of high cytonuclear grade. Overexpression of the c-erb-B2 oncogene was detectable in 83% of cases. Patients with Paget disease had a significantly worse survival than matched controls, but this difference was eliminated if they were also matched for c-erb-B2 status. CONCLUSIONS: Paget disease is often associated with extensive underlying malignancy, which is difficult to assess accurately either clinically or mammographically. As a consequence, cone excision of the nipple would have resulted in incomplete excision in 75% of cases. The underlying disease is of high grade and is frequently c-erb-B2 positive with a resulting poor prognosis. Aggressive local and systemic treatment would seem to be merited.  (+info)

(8/37) Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results.

BACKGROUND: At 5-year follow-up, patients with Paget disease of the breast who were treated with breast-conserving surgery (BCS) and radiotherapy (RT) had excellent results. The current report provides 10- and 15-year rates of tumor control in the breast, as well as disease-free and overall survival rates following BCS and RT in a cohort of patients with Paget disease presenting without a palpable mass or mammographic density. METHODS: Through a collaborative review of patients treated with BCS and RT from seven institutions, 38 cases of Paget disease of the breast presenting without a palpable mass or mammographic density were identified. All patients had pathologic confirmation of typical Paget cells at time of diagnosis. Thirty-six of 38 patients had a minimum follow-up greater than 12 months and constitute the study cohort. Ninety-four percent of patients underwent complete or partial excision of the nipple-areola complex and all patients received a median external beam irradiation dose of 50 Gy (range, 45-54 Gy) to the whole breast. Ninety-seven percent of patients also received a boost to the remaining nipple or tumor bed, a median total dose of 61.5 Gy (range, 50.4-70 Gy). RESULTS: With median follow-up of 113 months (range, 18-257 months), 4 of 36 patients (11%) developed a first recurrence of disease in the treated breast only. Two of the four recurrences in the breast were ductal carcinoma in situ (DCIS) only and two were invasive with DCIS. Two additional patients had a recurrence in the breast as a component of first failure. Actuarial local control rates for the breast as the only site of first recurrence were 91% at 5 years (95% confidence interval [CI], 80-100%) and 87% (95% CI, 75-99%) at both 10 and 15 years. Actuarial local control rates for breast recurrence, as a component of first failure, were 91% (95% CI, 80-100%), 83% (95% CI, 69-97%), and 76% (95% CI, 58-94%) at 5, 10, and 15 years, respectively. No clinical factors were identified as significant predictors for breast recurrence. Five-, 10- and 15-year actuarial rates for survival without disease of 97% (95% CI, 90-100%) and 5-, 10-, and 15-year actuarial rates of overall survival of 93% (95% CI, 84-100%) at 5 years and 90% (95% CI, 78-100%) at 10 and 15 years were reported. CONCLUSIONS: These data confirm excellent rates of local control, disease-free survival, and overall survival at 10 and 15 years following BCS and RT for Paget disease of the breast. This study continues to support the recommendation of local excision and definitive breast irradiation as an alternative to mastectomy in the treatment of patients with Paget disease presenting without a palpable mass or mammographic density.  (+info)

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