*  Pharmaceuticals | Free Full-Text | Cyclooxygenase (COX) Inhibitors and the Newborn Kidney | HTML

All major organs, such as the brain, heart, lungs, uterus and kidney, abundantly express both COX isoforms. The most recently ... as well as the specificity of the antibodies used in the immunohistochemical analyses, with the latter study using anti-human ...

*  ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS | Biochemical...

ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS. WA WITHYCOMBE, DT ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ... ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS ...

*  Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns - Zurich Open...

Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns ... Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ...

*  Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice | Cancer Prevention...

Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice. Jae-In Yoon, Sang-In ... We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of ... Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice ... Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice ...

*  Antinuclear factors in rheumatoid arthritis. Increasing organ-non-specificity with increasing reactivity of rheumatoid factor...

Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ... Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ...

*  mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of...

Organ Specificity. Protein Structure, Tertiary / physiology. Sequence Analysis, DNA. Sequence Homology, Amino Acid. ...

*  Relaxin regulates endometrial structure and function in the rhesus monkey.

Organ Specificity. Receptors, G-Protein-Coupled. Receptors, Peptide / metabolism. Receptors, Steroid / metabolism. Relaxin / ...

*  Tissue and developmental specificity of a polysialo-ganglioside species in the amphibian Xenopus.

Organ Specificity. Palmitic Acid / analysis. Species Specificity. Spinal Cord / chemistry. Tilapia / metabolism*. Xenopus ...

*  Leukocyte migration is regulated by L-selectin endoproteolytic release.

Organ Specificity. Grant Support. ID/Acronym/Agency: CA54464/CA/NCI NIH HHS; CA81776/CA/NCI NIH HHS ...

*  The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.

Organ Specificity. Osteoclasts / pathology. Osteopetrosis / blood, embryology, pathology*. Phagocytes / drug effects*. Placenta ... 16557874 - Pathological changes in brain and other target organs of infant and weanling mice after.... 15285784 - Maternal ... the first fetal organ perfused by placental blood. However, because some Mphi developed in the complete absence of CSF-1, other ...

*  Table of Contents - July 01, 1959, 83 (1) | The Journal of Immunology

Studies on Organ Specificity Noel R. Rose and Ernest Witebsky. J Immunol July 1, 1959, 83 (1) 34-40; ...

*  Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR...

Organ Specificity / drug effects, genetics. Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors*, metabolism. ...

*  Understanding Population and Individual Risk Assessment: The Case of Polychlorinated Biphenyls | Cancer Epidemiology,...

With only a few exceptions, chemicals exert organ-specific carcinogenic effects in humans and animals. Target organ specificity ... Target organ specificity is demonstrable in people who have sufficient exposures, e.g., predictable second cancer patterns ... Thus, for both exposure to PCBs as a single agent and in tumor promotion studies, we see target-organ specificity in laboratory ... The target organ for PCB tumorigenicity in animals is the liver (see discussion below for initiation-promotion models). Four ...

*  Plus it

Organ specificity and conformation specificity. Eur J Biochem 143:599-605.. OpenUrlPubMed ...

*  23rd International Conference on Cancer Research & Pharmacology (pgr) AS Tickets, Mon, Mar 26, 2018 at 9:00 AM | Eventbrite

4.Organ Based Cancers. Cancer has a diversified nature in relation to the organ specificity. Cancer is a group of more than 100 ... Organ Specific Cancers are cancers named basing on the location of cancer in the body organ. The various types of cancers ... In most organs and tissues of a mature animal, a balance is maintained between cell renewal and cell death. The various types ... Metastasis is the spread of a cancer or other disease from one organ or part of the body to another without being directly ...

*  Center for Theoretical & Mathematical Sciences » People

Organ Culture Techniques • Organ Size • Organ Specificity • ortho-Aminobenzoates • Osmolar Concentration • Oxidative Stress • ... This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism ... This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism ... 2) The regulation of organ and body size in insects. Ongoing research deals with the mechanism by which insects asses their ...

*  NYU Cancer Institute Experts Present At The AACR 102nd Annual Meeting 2011 - Redorbit

The study results provide molecular explanations to the puzzling organ and species specificity of BBN, and indicate that BBN- ... Researchers found mutagenesis correlated with the organ specificity for cancer induction by BBN. ... the reason for such a high degree of organ specificity is unclear. BBN is a primary metabolite of the environmental carcinogen ... Organ, Species and Sex Differences in Mutagenesis Induced by butyl-hydroxybutyl-N-nitrosamine in Big Blue Transgenic Rodents as ...

*  basaloid skin squamous cell carcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Organ Specificity. Papillomavirus E7 Proteins. Papillomavirus Infections / metabolism. Papillomavirus Infections / pathology. ...

*  The Amniotic Fluid Transcriptome: A Source of Novel Informat... : Obstetrics & Gynecology

Organ specificity was examined for each transcript using a gene expression atlas. For fetal organs not represented in the atlas ... We categorized probe sets as highly organ-specific if they mapped to a single organ with an expression value more than 30 ... The reliance on the presence of "organ-specific genes" to identify putative organ sources is subject to an inherent bias in the ... Twenty-three highly organ-specific transcripts were identified; six of these are known to be highly expressed in the fetal ...

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Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. PubMed: ...

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Organ specificity of the dopamine1 receptor/adenylate cyclase coupling defect in spontaneously hypertensive rats. Am J Physiol. ...

*  ZFIN Publication: Higdon et al., 2013

Organ Specificity/genetics; Retinal Pigment Epithelium/metabolism*; Zebrafish/embryology; Zebrafish/genetics*; Zebrafish/ ...

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Species and organ specificity of fumonisin-induced endothelial alterations: potential role in porcine pulmonary edema. ... Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and ...

*  An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the Aire-Deficient Mouse | The Journal of...

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116: 1292-1301. ... Preparation of cDNA from organs. RNA from various organs was prepared according to manufacturers instructions using a mini RNA ... Amplification of OBP1a and cyclophilin from organs. PCR was used to amplify OBP1a or cyclophilin from various organs. Primers ... the only organs from which detectable levels of transcript were identified were the lacrimal gland and the vomeronasal organ ( ...

*  PPT - Receptor theory PowerPoint presentation | free to view - id: 8f423-YWE0N

accordance with target organ specificity. * Receptor must possess a high affinity for the hormone at physiological ... specificity for a hormone and for its close analogs as well. * Receptors are saturable and limited (i.e. there is a finite ... Tissue specificity binding should occur in tissues known to be sensitive to the endogenous ligand. Binding should occur at ... Agonist specificity structurally related drugs should bind well, while physically dissimilar compounds should bind poorly. ...

(1/12667) A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

1 The affinity of 17 compounds for muscarine-sensitive acetylcholine receptors in atrial pacemaker cells and ileum of the guinea-pig has been measured at 29 degrees C in Ringer-Locke solution. Measurements were also made at 37 degrees C with 7 of them. 2 Some of the compounds had much higher affinity for the receptors in the ileum than for those in the atria. For the most selective compound, 4-diphenylacetoxy-N-methylpiperidine methiodide, the difference was approximately 20-fold. The receptors in the atria are therefore different the structure from those in the ileum. 3 The effect of temperature on affinity are not the same for all the compounds, tested indicating different enthalpies and entropies of adsorption and accounting for some of the difficulty experienced in predicting the affinity of new compounds.  (+info)

(2/12667) The mouse Aire gene: comparative genomic sequencing, gene organization, and expression.

Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.  (+info)

(3/12667) RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.  (+info)

(4/12667) A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate expression.

The heart fatty acid-binding protein (HFABP) is a member of a family of binding proteins with distinct tissue distributions and diverse roles in fatty acid metabolism, trafficking, and signaling. Other members of this family have been shown to possess concise promoter regions that direct appropriate tissue-specific expression. The basis for the specific expression of the HFABP has not been previously evaluated, and the mechanisms governing expression of metabolic genes in the heart are not completely understood. We used transient and permanent transfections in ventricular myocytes, skeletal myocytes, and nonmyocytic cells to map regulatory elements in the HFABP promoter, and audited results in transgenic mice. Appropriate tissue-specific expression in cell culture and in transgenic mice was dictated by 1.2 kb of the 5'-flanking sequence of FABP3, the HFABP gene. Comparison of orthologous murine and human genomic sequences demonstrated multiple regions of near-identity within this promoter region, including a CArG-like element close to the TATA box. Binding and transactivation studies demonstrated that this element can function as an atypical myocyte enhancer-binding factor 2 site. Interactions with adjacent sites are likely to be necessary for fully appropriate, tissue-specific, developmental and metabolic regulation.  (+info)

(5/12667) Integrin subunit gene expression is regionally differentiated in adult brain.

Integrins are a diverse family of heterodimeric (alphabeta) adhesion receptors recently shown to be concentrated within synapses and involved in the consolidation of long-term potentiation. Whether neuronal types or anatomical systems in the adult rat brain are coded by integrin type was studied in the present experiments by mapping the relative densities of mRNAs for nine alpha and four beta subunits. Expression patterns were markedly different and in some regions complementary. General results and areas of notable labeling were as follows: alpha1-limited neuronal expression, neocortical layer V, hippocampal CA3; alpha3 and alpha5-diffuse neuronal and glial labeling, Purkinje cells, hippocampal stratum pyramidale, locus coeruleus (alpha3); alpha4- discrete limbic regions, olfactory cortical layer II, hippocampal CA2; alpha6-most prominently neuronal, neocortical subplate, endopiriform, subiculum; alpha7-discrete, all neocortical layers, hippocampal granule cells and CA3, cerebellar granule and Purkinje cells, all efferent cranial nerve nuclei; alpha8-discrete neuronal, deep cortex, hippocampal CA1, basolateral amygdala, striatum; alphaV-all cortical layers, striatum, Purkinje cells; beta4-dentate gyrus granule cells; beta5-broadly distributed, neocortex, medial amygdala, cerebellar granule and Purkinje cells, efferent cranial nerve nuclei; alpha2, beta2, and beta3-mRNAs not detected. These results establish that brain subfields express different balances of integrin subunits and thus different integrin receptors. Such variations will determine which matrix proteins are recognized by neurons and the types of intraneuronal signaling generated by matrix binding. They also could generate important differences in synaptic plasticity across brain systems.  (+info)

(6/12667) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells. The resultant mice exhibit a selective loss of insulin secretion in response to glucose and a progressive impairment of glucose tolerance. These data indicate an important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell and suggest that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.  (+info)

(7/12667) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells.

Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.  (+info)

(8/12667) The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution.

Latrophilin is a brain-specific Ca2+-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds alpha-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.  (+info)



mice

  • We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. (aacrjournals.org)
  • In confirmation, we show a predominant and sustained mutagenic effect of 4-ABP in bladder, and much weaker but significant mutagenicity of 4-ABP in the kidney and liver of carcinogen-treated mice, as reflected by the elevation of background cII mutant frequency in the respective organs. (aacrjournals.org)

Sensitivity

  • The sensitivity and the specificity of these criteria for differentiating AIP from neoplasia are unknown. (wikipedia.org)

tissues

  • Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass spectrometry. (uzh.ch)
  • This process of decellularizing tissues and organs is still being developed, but the exact process of taking a tissue from a donor and removing all the cellular components is considered to be the decellularization process. (wikipedia.org)
  • As is a basic organizing theme in biological systems, greater complexity of a body system, such as tissues and organs allows for greater specificity of function. (wikipedia.org)

carcinogen

  • We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of carcinogen-treated animals, which accords with the bioactivation pathway of this chemical in the respective organs. (aacrjournals.org)
  • It is suggested that a CYP- or peroxidase-mediated activation of Sudan I or a combination of both mechanisms as an explanation for the organ specificity of this carcinogen for liver and urinary bladder in animals. (wikipedia.org)

Receptors

  • The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity as the parental cell. (wikipedia.org)

ligands

  • A majority of radiopharmaceuticals labelled with 99mTc are synthesized by the reduction of the pertechnetate ion in the presence of ligands chosen to confer organ specificity of the drug. (wikipedia.org)
  • Such imaging can be enhanced by manipulation of the ligands in a complex to create specificity so that the complex will be taken up by a certain cell or organ type. (wikipedia.org)

fetal organ

  • Compensation for total absence of local CSF-1 production by circulating, maternal CSF-1 is tissue-specific and most prominent in liver, the first fetal organ perfused by placental blood. (biomedsearch.com)
  • For fetal organs not represented in the atlas, manual literature searching and the web-based software analysis tool were used to generate fetal organ-associated gene lists. (lww.com)
  • Amniotic fluid cell-free fetal RNA can provide biological information on multiple fetal organ systems. (lww.com)

species

  • Tissue and developmental specificity of a polysialo-ganglioside species in the amphibian Xenopus. (biomedsearch.com)
  • There is evidence of host specificity and selection of particular biting sites for some species. (wikipedia.org)

Muscles

  • Successful axons can therefore reconnect with the muscles or organs they previously controlled with the help of Schwann cells, however, specificity is not maintained and errors are frequent, especially when long distances are involved. (wikipedia.org)

liver

  • In particular, much higher concentration of such enzymes are found in the kidneys and in the liver, making such organs the primary site for alcohol catabolism. (wikipedia.org)

Steroid

  • The ICDC emphasizes five cardinal features of AIP which includes the imaging appearance of pancreatic parenchyma and the pancreatic duct, serum IgG4 level, other organ involvement with IgG4-related disease, pancreatic histology and response to steroid therapy. (wikipedia.org)
  • Mayo Clinic has come up with five diagnostic criteria called HISORt criteria which stands for histology, imaging, serology, other organ involvement, and response to steroid therapy. (wikipedia.org)

gamma

  • Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. (bmj.com)
  • The gamma radiation emitted by the radionuclide allows organs to be imaged in vivo tomographically. (wikipedia.org)

host

  • Like other mollicutes, they show a high host specificity. (wikipedia.org)
  • As A. fischeri cells aggregate in the mucus, they must use their flagella to migrate through the pores and down into the ciliated ducts of the light organ and endure another barrage of host factors meant to ensure only A. fischeri colonization. (wikipedia.org)

cell

  • One of the greatest limitations to organ transplantation derives from organ rejection caused by antibodies of the transplant recipient reacting to donor antigens on cell surfaces within the donor organ. (wikipedia.org)

body

  • 2) The regulation of organ and body size in insects. (duke.edu)
  • This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism but that it is a systems property in which cellular, physiological and environmental signals all contribute in inextricable ways to produce the final phenotype. (duke.edu)
  • The energy emitted from 99mTc is 140 keV, which allows for the study of deep body organs. (wikipedia.org)

examples

  • Other examples of organ-specific radiopharmaceuticals include: 99mTc is conveniently available in high radionuclidic purity from molybdenum-99, which decays with 87% probability to 99mTc. (wikipedia.org)

However

  • Nonluminescent strains of V. fischeri would have a definite competitive advantage over the luminescent wild-type, however nonluminescent mutants are never found in the light organ of the E. scolopes. (wikipedia.org)

function

  • Radiopharmaceuticals containing 99mTc are currently being applied in the determining morphology of organs, testing of organ function, and scintigraphic and emission tomographic imaging. (wikipedia.org)

different

  • These encompass two (gastric and enterohepatic) groups, showing different organ specificity. (wikipedia.org)
  • As far as introducing the different liquidized chemicals and enzymes to an organ or tissue, perfusion and immersion decellularization techniques have been used. (wikipedia.org)

system

  • Perfusion decellularization is applicable when an extensive vasculature system is present in the organ or tissue. (wikipedia.org)

type

  • The clonal selection theory can be summarised with the following four tenets: Each lymphocyte bears a single type of receptor with a unique specificity (by V(D)J recombination). (wikipedia.org)

cells

  • Decellularization (also spelt decellularisation in British English) is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of a tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration. (wikipedia.org)
  • Scientists can use the acquired ECM scaffold to reproduce a functional organ by introducing progenitor cells, or adult stem cells (ASCs), and allowing them to differentiate within the scaffold to develop into the desired tissue. (wikipedia.org)
  • Under this mechanism and proper physiological conditions, treatments can diffuse equally to all of the cells within the organ. (wikipedia.org)
  • Female midges most likely detect their hosts using a specialized organ called a Johnston's organ, a collection of sensory cells found on the second antenna segment. (wikipedia.org)

provide

  • Our data support a possible etiologic role of 4-ABP in bladder carcinogenesis, and provide a mechanistic view on how DNA-adduct-driven mutagenesis, specifically targeted to bladder urothelium, may account for organ-specific tumorigenicity of this chemical. (aacrjournals.org)

variety

  • Organ and tissue transplantation treat a variety of medical problems, ranging from end organ failure to cosmetic surgery. (wikipedia.org)
  • The mucus inundates the ciliated fields in the immediate area around the six pores of the light organ and captures a large variety of bacteria. (wikipedia.org)