*  Organ specificity in the plant circadian clock - Enlighten: Theses

Bordage, Simon (2013) Organ specificity in the plant circadian clock. PhD thesis, University of Glasgow. ... Together my results confirmed that the plant circadian clock is organ specific and suggest that it is organ autonomous. ... In plants, the circadian clock was recently shown to be organ specific. The root clock seemed to involve only a morning loop ... Plant, circadian clock, arabidopsis, molecular biology, imaging, systems biology, modelling, parameter optimisation, organ, ...
theses.gla.ac.uk/4387/

*  DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide -- elucidation of organ-specificity and the role...

DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide -- elucidation of organ-specificity and the role ... The standard procedure of the comet assay was applied to gill and liver cells in order to determine organ-specific genetic ... Since liver is a central organ in xenobiotic metabolism, nucleoids of hepatic cells were also incubated with a lesion-specific ...
https://omicsonline.org/references/dna-damage-in-fish-anguilla-anguilla-exposed-to-a-glyphosatebased-herbicide-elucidation-of-organspecificity-and-the-role-of-oxidative-stress-1523005.html

*  Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns - Zurich Open...

Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns ... Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ... Here, we provide an organ-wide map of lysine acetylation sites from 16 rat tissues analyzed by high-resolution tandem mass ...
zora.uzh.ch/id/eprint/66903/

*  Antinuclear factors in rheumatoid arthritis. Increasing organ-non-specificity with increasing reactivity of rheumatoid factor...

Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ... Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin. ...
ard.bmj.com/content/27/5/406

*  Radioimmunoassay for hypocretin-2.

Organ Specificity. Quality Control. Rabbits. Radioimmunoassay*. Rats. Rats, Wistar. Testis / chemistry. Chemical. ... Antibody Specificity. Brain Chemistry. Brain Stem / chemistry. Hypothalamus / chemistry. Intracellular Signaling Peptides and ...
biomedsearch.com/nih/Radioimmunoassay-hypocretin-2/10808249.html

*  Immunohistochemical localization of somatostatin receptor type 2A in rat and human tissues.

Organ Specificity. Pituitary Gland / chemistry. Rats. Receptors, Somatostatin / analysis*. Species Specificity. Tissue ... Antibody Specificity. Digestive System / chemistry. Humans. Immunohistochemistry*. Islets of Langerhans / chemistry. Kidney / ...
biomedsearch.com/nih/Immunohistochemical-localization-somatostatin-receptor-type/11403108.html

*  Table of Contents - August 01, 1963, 91 (2) | The Journal of Immunology

Studies on Organ Specificity Ernst H. Beutner and Ernest Witebsky. J Immunol August 1, 1963, 91 (2) 204-209; ...
jimmunol.org/content/91/2

*  Table of Contents - July 01, 1959, 83 (1) | The Journal of Immunology

Studies on Organ Specificity Noel R. Rose and Ernest Witebsky. J Immunol July 1, 1959, 83 (1) 34-40; ...
jimmunol.org/content/83/1

*  ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

Organ Specificity / physiology. Rats. Up-Regulation / physiology*. Xenopus laevis. Grant Support. ID/Acronym/Agency: R01 ...
biomedsearch.com/nih/ZIP8-Iron-Zinc-Transporter-Whose/22898811.html

*  Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR...

Organ Specificity / drug effects, genetics. Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors*, metabolism. ...
biomedsearch.com/nih/Gut-Microbiota-Regulates-Bile-Acid/23395169.html

*  Suppression of α-amylase genes improves quality of rice grain ripened under high temperature - Hakata - 2012 - Plant...

Figure S5 Organ specificity of expression of α-amylase genes in ripening grain. ...
onlinelibrary.wiley.com/doi/10.1111/j.1467-7652.2012.00741.x/full?globalMessage=0&systemMessage=Wiley Online Library will be unavailable on Saturday 7th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 08.00 EDT / 13.00 BST / 17:30 IST / 20.00 SGT and Sunday 8th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 06.00 EDT / 11.00 BST / 15:30 IST / 18.00 SGT for essential maintenance. Apologies for the inconvenience caused

*  Items where Division is "College of Science | School of Life Sciences" and Year is 1997 - The Lincoln Repository

Organ Specificity. Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and ... Central Mutation NMR Spectroscopy Negibacteria Neoplasm Proteins Nitrendipine Nuclear Family Organ Specificity Oxidation- ... Antibody Specificity. Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and ... Sensitivity and Specificity. Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H ...
eprints.lincoln.ac.uk/view/divisions/sch=5Fdbs/1997.keywords.html

*  Plus it

Ribatti D, Nico B, Vacca A, Roncali L, Dammacco F: Endothelial cell heterogeneity and organ specificity. J Hematother Stem Cell ... Lifson N, Lassa CV, Dixit PK: Relation between blood flow and morphology in islet organ of rat pancreas. Am J Physiol 249 : E43 ...
diabetes.diabetesjournals.org/content/55/11/2974

*  Brain Metastases from Endometrial Carcinoma

G. L. Nicolson and J. L. Winkelhake, "Organ specificity of blood borne tumour metastasis determined by cell adhesion?" Nature, ... I. J. Fidler, "The role of the organ microenvironment in brain metastasis," Seminars in Cancer Biology, vol. 21, no. 2, pp. 107 ...
https://hindawi.com/journals/isrn/2012/581749/

*  Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic...

To define the qualitative and quantitative toxicities of flavopiridol in regard to organ specificity, time course, ...
https://clinicaltrials.gov/ct2/show/NCT00101231?cond="Acute myeloblastic leukemia without maturation"&rank=17

*  JCI - The biology and function of exosomes in cancer

... likely reflecting cellular and organ specificity. This second layer of complexity is dynamic and can change with the evolving ... This suggests that certain proteins are transported to the exosomes with some degree of specificity. Additionally, distinct ... status of the organ and cells within. Here, the pancreas is provided as an example, but this dynamism in exosomal contents ... complex phenomenon than cellular heterogeneity and can be fleeting depending on stimuli and the functional status of the organ ...
https://jci.org/articles/view/81135/figure/1

*  3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - Full Text View - ClinicalTrials.gov

I. To define the qualitative and quantitative toxicities of the 3-AP/GEM combination in regard to organ specificity, time ...
https://clinicaltrials.gov/ct2/show/NCT00293345?recr=Open&cond="Lymphoma, Non-Hodgkin"&rank=16

*  Plus it

... suggest a mechanism whereby iron may mediate cysteamine-induced duodenal ulcer development and explain the organ specificity ... which may contribute to organ-specific tissue damage. Since most intestinal iron absorption takes place in the proximal ... and suggest a role for iron in the pathogenesis of organ-specific tissue injury such as duodenal ulcers. ... Previous studies have also demonstrated that increased iron accumulation in tissues can lead to organ damage and dysfunction. ...
ajpgi.physiology.org/content/296/6/G1277

*  IFNγ, IL-10, and IL-2R mRNA of TGFP cells within the C | Open-i

The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune ... The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211765_20031064f4&req=4

*  Recruitment of EPDCs and MSCs inside myotubes is stimul | Open-i

Organ Specificity/genetics. *Phenotype. *Receptors, Interleukin-4/metabolism. *Stromal Cells/cytology/metabolism/ ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3046056_581fig7&req=4

*  Blood-brain barrier building blocks forged from human ... ( MADISON -- The blood-brain barrier --...)

... the cells secrete chemical cues that help determine organ specificity.. "We don't know what all those factors are," Lippmann ...
bio-medicine.org/biology-news-1/Blood-brain-barrier-building-blocks-forged-from-human-stem-cells-25495-1/

*  Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new...

Organ Specificity, Prostate, Seminal Vesicles ...
epubs.surrey.ac.uk/826816/

*  Complete antigen | definition of complete antigen by Medical dictionary

Two types of organ specificity have been proposed: (1) first-order or tissue specificity is attributed to the presence of an ... second-order organ specificity is attributed to an antigen characteristic of the same organ in many, even unrelated species. ... organ-specific antigen. any antigen that occurs exclusively in a particular organ and serves to distinguish it from other ... antigen characteristic of a particular organ in a single species; (2) ...
https://medical-dictionary.thefreedictionary.com/complete antigen

*  ras proteins

ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS. Michael Gould; Fiscal Year: 2001. ..in the Ras protein itself, Aim 1 will test ...
https://labome.org/topics/chemicals/and/peptides/intracellular/monomeric/ras-proteins-12369.html

*  Pfam: Family: CD36 (PF01130)

"Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns". Cell Reports ...
pfam.xfam.org/family/PF01130

(1/12667) A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

1 The affinity of 17 compounds for muscarine-sensitive acetylcholine receptors in atrial pacemaker cells and ileum of the guinea-pig has been measured at 29 degrees C in Ringer-Locke solution. Measurements were also made at 37 degrees C with 7 of them. 2 Some of the compounds had much higher affinity for the receptors in the ileum than for those in the atria. For the most selective compound, 4-diphenylacetoxy-N-methylpiperidine methiodide, the difference was approximately 20-fold. The receptors in the atria are therefore different the structure from those in the ileum. 3 The effect of temperature on affinity are not the same for all the compounds, tested indicating different enthalpies and entropies of adsorption and accounting for some of the difficulty experienced in predicting the affinity of new compounds.  (+info)

(2/12667) The mouse Aire gene: comparative genomic sequencing, gene organization, and expression.

Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.  (+info)

(3/12667) RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.  (+info)

(4/12667) A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate expression.

The heart fatty acid-binding protein (HFABP) is a member of a family of binding proteins with distinct tissue distributions and diverse roles in fatty acid metabolism, trafficking, and signaling. Other members of this family have been shown to possess concise promoter regions that direct appropriate tissue-specific expression. The basis for the specific expression of the HFABP has not been previously evaluated, and the mechanisms governing expression of metabolic genes in the heart are not completely understood. We used transient and permanent transfections in ventricular myocytes, skeletal myocytes, and nonmyocytic cells to map regulatory elements in the HFABP promoter, and audited results in transgenic mice. Appropriate tissue-specific expression in cell culture and in transgenic mice was dictated by 1.2 kb of the 5'-flanking sequence of FABP3, the HFABP gene. Comparison of orthologous murine and human genomic sequences demonstrated multiple regions of near-identity within this promoter region, including a CArG-like element close to the TATA box. Binding and transactivation studies demonstrated that this element can function as an atypical myocyte enhancer-binding factor 2 site. Interactions with adjacent sites are likely to be necessary for fully appropriate, tissue-specific, developmental and metabolic regulation.  (+info)

(5/12667) Integrin subunit gene expression is regionally differentiated in adult brain.

Integrins are a diverse family of heterodimeric (alphabeta) adhesion receptors recently shown to be concentrated within synapses and involved in the consolidation of long-term potentiation. Whether neuronal types or anatomical systems in the adult rat brain are coded by integrin type was studied in the present experiments by mapping the relative densities of mRNAs for nine alpha and four beta subunits. Expression patterns were markedly different and in some regions complementary. General results and areas of notable labeling were as follows: alpha1-limited neuronal expression, neocortical layer V, hippocampal CA3; alpha3 and alpha5-diffuse neuronal and glial labeling, Purkinje cells, hippocampal stratum pyramidale, locus coeruleus (alpha3); alpha4- discrete limbic regions, olfactory cortical layer II, hippocampal CA2; alpha6-most prominently neuronal, neocortical subplate, endopiriform, subiculum; alpha7-discrete, all neocortical layers, hippocampal granule cells and CA3, cerebellar granule and Purkinje cells, all efferent cranial nerve nuclei; alpha8-discrete neuronal, deep cortex, hippocampal CA1, basolateral amygdala, striatum; alphaV-all cortical layers, striatum, Purkinje cells; beta4-dentate gyrus granule cells; beta5-broadly distributed, neocortex, medial amygdala, cerebellar granule and Purkinje cells, efferent cranial nerve nuclei; alpha2, beta2, and beta3-mRNAs not detected. These results establish that brain subfields express different balances of integrin subunits and thus different integrin receptors. Such variations will determine which matrix proteins are recognized by neurons and the types of intraneuronal signaling generated by matrix binding. They also could generate important differences in synaptic plasticity across brain systems.  (+info)

(6/12667) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells. The resultant mice exhibit a selective loss of insulin secretion in response to glucose and a progressive impairment of glucose tolerance. These data indicate an important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell and suggest that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.  (+info)

(7/12667) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells.

Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.  (+info)

(8/12667) The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution.

Latrophilin is a brain-specific Ca2+-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds alpha-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.  (+info)



oxidative stress


  • DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide -- elucidation of organ-specificity and the role of oxidative stress. (omicsonline.org)
  • This reducing aminothiol generates hydrogen peroxide in the presence of transition metals (e.g., ferric iron), producing oxidative stress, which may contribute to organ-specific tissue damage. (physiology.org)
  • These results indicate an expansion of the intracellular labile iron pool in the duodenal mucosa, increasing its susceptibility to oxidative stress, and suggest a role for iron in the pathogenesis of organ-specific tissue injury such as duodenal ulcers. (physiology.org)

proteins


  • B ) It has been assumed that exosomes are cellular trash bags for elimination of excess proteins, but many studies have shown that exosomes often exhibit certain specific markers, irrespective of the organ or cellular source. (jci.org)
  • This suggests that certain proteins are transported to the exosomes with some degree of specificity. (jci.org)

specific


  • In plants, the circadian clock was recently shown to be organ specific. (gla.ac.uk)
  • Together my results confirmed that the plant circadian clock is organ specific and suggest that it is organ autonomous. (gla.ac.uk)
  • The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. (nih.gov)

cells


  • This second layer of complexity is dynamic and can change with the evolving status of the organ and cells within. (jci.org)

status


  • Therefore, exosome heterogeneity is a much more complex phenomenon than cellular heterogeneity and can be fleeting depending on stimuli and the functional status of the organ. (jci.org)