A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.
A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.
Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.
The prelarval stage of Filarioidea in the blood and other tissues of mammals and birds. They are removed from these hosts by blood-sucking insects in which they metamorphose into mature larvae.
Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Pharmacological agents destructive to nematodes in the superfamily Filarioidea.
Deoxyribonucleic acid that makes up the genetic material of helminths.
Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.
A genus of parasitic nematodes found throughout the rain-forest areas of the Sudan and the basin of the Congo. L. loa inhabits the subcutaneous tissues, which it traverses freely.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
Proteins found in any species of helminth.
A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.
Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
A superfamily of nematodes of the suborder SPIRURINA. Its organisms possess a filiform body and a mouth surrounded by papillae.
Drugs used to treat or prevent parasitic infections.
An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A filarial nematode parasite of mammalian blood with the vector being a tick or small fly.
A genus of parasitic nematodes whose organisms are distributed in Central and South America. Characteristics include a smooth cuticle and an enlarged anterior end.
A genus of bacteria comprised of a heterogenous group of gram-negative small rods and coccoid forms associated with arthropods. (From Bergey's Manual of Systematic Bacteriology, vol 1, 1984)
A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.
I'm sorry for any confusion, but "Guatemala" is not a medical term and does not have a medical definition. Guatemala is the name of a country located in Central America, known officially as the Republic of Guatemala. If you have any questions related to medical topics or definitions, I would be happy to help with those!
A republic in western Africa, lying between GHANA on its west and BENIN on its east. Its capital is Lome.
I'm sorry for any confusion, but "Ecuador" is a country in South America and not a medical term. The term you might be looking for is "ecdysone," which is a hormone found in arthropods that controls their molting process.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A republic in western Africa, south of GUINEA and east of COTE D'IVOIRE. Its capital is Monrovia.
Inflammation of the cornea.
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.
A republic in western Africa, south of SENEGAL and MALI, east of GUINEA-BISSAU. Its capital is Conakry.
A genus of parasitic nematodes found in the peritoneal cavity of wild or domestic cattle or equines.
A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.
The geographical area of Africa comprising BENIN; BURKINA FASO; COTE D'IVOIRE; GAMBIA; GHANA; GUINEA; GUINEA-BISSAU; LIBERIA; MALI; MAURITANIA; NIGER; NIGERIA; SENEGAL; SIERRA LEONE; and TOGO.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Pathological developments in the CECUM.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
I'm sorry for any confusion, but "Mexico" is not a medical term and does not have a medical definition. It is the name of a country located in North America, known officially as the United Mexican States. If you have any questions related to medical topics or terminology, I would be happy to help answer those!
Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.
The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Inflammation of the throat (PHARYNX).
Infections with bacteria of the genus STREPTOCOCCUS.
A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.
A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.
Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.

Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (1/208)

OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.  (+info)

Distribution of the blinding and nonblinding strains of Onchocerca volvulus in Nigeria. (2/208)

Onchocerciasis remains an important public health problem throughout much of sub-Saharan Africa. Nigeria is the country whose population is most afflicted by onchocerciasis; however, little is known concerning the epidemiology of onchocerciasis in this country. Previous studies demonstrated that onchocerciasis in West Africa exists in two forms, which differ in their clinical and epidemiologic characteristics. This is believed to be due to the existence of 2 strains of Onchocerca volvulus, the causative agent of onchocerciasis. The O-150 polymerase chain reaction has been developed to differentiate these 2 strains, and this method has been used to map the distribution of the blinding and nonblinding strains of O. volvulus in Nigeria. The strain distribution is consistent with what is known concerning the ecology and epidemiology of onchocerciasis in this country. The results also suggest that migration may be affecting the historic distribution of the 2 strains of the parasite in Nigeria.  (+info)

Population biology of human onchocerciasis. (3/208)

Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector. Some 86 million people around the world are at risk of acquiring the nematode, with 18 million people infected and 600,000 visually impaired, half of them partially or totally blind. 99% of cases occur in tropical Africa; scattered foci exist in Latin America. Until recently control programmes, in operation since 1975, have consisted of antivectorial measures. With the introduction of ivermectin in 1988, safe and effective chemotherapy is now available. With the original Onchocerciasis Control Programme of West Africa coming to an end, both the new African Programme for Onchocerciasis Control and the Onchocerciasis Elimination Programme for the Americas, rely heavily on ivermectin self-sustained mass delivery. In consequence, the need for understanding the processes regulating parasite abundance in human and simuliid populations is of utmost importance. We present a simple mathematical framework built around recent analyses of exposure- and density-dependent processes operating, respectively, within the human and vector hosts. An expression for the basic reproductive ratio, R0, is derived and related to the minimum vector density required for parasite persistence in localities of West Africa in general and northern Cameroon in particular. Model outputs suggest that constraints acting against parasite establishment in both humans and vectors are necessary to reproduce field observations, but those in humans may not fully protect against reinfection. Analyses of host age-profiles of infection prevalence, intensity, and aggregation for increasing levels of endemicity and intensity of transmission in the Vina valley of northern Cameroon are in agreement with these results and discussed in light of novel work on onchocerciasis immunology.  (+info)

Induction of histamine release in parasitized individuals by somatic and cuticular antigens from Onchocerca volvulus. (4/208)

The host immune response in onchocerciasis is believed to contribute to the clinical manifestations of infection. Mazzotti and chronic inflammatory reactions might be mediated by mechanisms involving specific IgE and reactivity of mast cells and basophils to the parasite antigens. In this report, we show that Onchocerca volvulus antigens are capable of inducing histamine release. Three types of extracts were prepared from the parasite: soluble total, surface, and cuticular collagen. Soluble extracts released histamine in all individuals with onchocerciasis at significantly higher levels (P < 0.05) than those found in endemic controls, but similar levels to those found in patients with mansonellosis. However, cuticular collagen induced significantly (P < 0.01) higher histamine release in patients with onchocerciasis than in those with mansonellosis. No reactivity against human type IV collagen was observed. Implications derived from the presence of sensitized basophils in the pathogenesis of onchocerciasis are discussed.  (+info)

Analysis of renal function in onchocerciasis patients before and after therapy. (5/208)

The occurrence of renal abnormalities was investigated in patients with onchocerciasis in comparison to individuals without onchocerciasis in Guinea. Serum creatinine levels, excretion of urinary marker proteins, and kidney size by ultrasound were determined. A high prevalence of glomerular as well as tubular dysfunctions was observed; however, no association with onchocerciasis could be detected. We also hypothesized that patients with hyperreactive onchocerciasis might be prone to develop immune-mediated glomerular disorders; however, this could not be verified. Following treatment with ivermectin, a slight but significant increase in the excretion of urinary albumin and alpha1-microglobulin was seen five days after treatment in all treated patients, whereas levels of proteinuria were significantly higher five days after treatment only in patients with high microfilarial densities. Our results indicate that ivermectin can cause glomerular and tubular disturbances in patients with onchocerciasis; however, these are minor and do not seem to be clinically relevant.  (+info)

Prenatal immune priming in onchocerciasis-onchocerca volvulus-specific cellular responsiveness and cytokine production in newborns from infected mothers. (6/208)

This study investigated the effect of maternal Onchocerca volvulus infection on humoral and cellular responsiveness in newborn children and their mothers. Onchocerca volvulus-specific IgG isotypes and IgE were significantly elevated in infected mothers and their infants. One year post partum, O. volvulus-specific IgG4 was strongly reduced in children of infected mothers, while IgG1 responses weakened only slightly. Umbilical cord mononuclear blood cells (UCBC) and peripheral blood cells (PBMC) from mothers proliferated in response to phytohaemagglutinin (PHA), concanavalin A (Con A), and the bacterial antigens streptolysin-O (SL-O) or purified protein derivative (PPD). UCBC from neonates born to O. volvulus-infected mothers responded lower (P < 0.01) to Con A (at 5 micrograms/ml), PPD (at 10 and 50 micrograms/ml) and O. volvulus-derived antigens (OvAg) (at 35 micrograms/ml), and in parallel, a diminished cellular reactivity (P < 0.01) by PBMC was observed to OvAg in mothers positive for O. volvulus. Several Th1-type (IL-2, IL-12, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha)) and Th2-type (IL-4, IL-5, IL-10, IL-13) cytokines were secreted by UCBC and PBMC in response to OvAg, bacterial SL-O and PHA. OvAg did not stimulate IL-2 and none of the mitogens or antigens induced production of IL-4 in neonates. In response to OvAg, substantially elevated (P < 0.01) amounts of IFN-gamma were produced by UCBC from newborns of O. volvulus-infected mothers. UCBC secreted low levels of IL-5 and IL-13, while higher amounts of IL-10 were found (P < 0. 01) in newborns from onchocerciasis-free mothers. In conclusion, maternal O. volvulus-infection will sensitize in utero parasite-specific cellular immune responsiveness in neonates and activate OvAg-specific production of several Th1- and Th2-type cytokines.  (+info)

Structural studies of N-glycans of filarial parasites. Conservation of phosphorylcholine-substituted glycans among species and discovery of novel chito-oligomers. (7/208)

N-Type glycans containing phosphorylcholine (PC-glycans), unusual structures found in the important human pathogens filarial nematodes, represent a novel target for chemotherapy. Previous work in our laboratories produced compositional information on the PC-glycan of ES-62, a secreted protein of the rodent parasite Acanthocheilonema viteae. In particular, we established using fast atom bombardment mass spectrometry (MS) analysis that PC was attached to a glycan with a trimannosyl core, with and without core fucosylation, carrying between one and four additional N-acetylglucosamine residues. In the present study, we demonstrate that this structure is conserved among filarial nematodes, including the parasite of humans, Onchocerca volvulus, for which new drugs are most urgently sought. Furthermore, by employing a variety of procedures, including collision-activated dissociation MS-MS analysis and matrix-assisted laser desorption MS analysis, we reveal that surprisingly, filarial nematodes also contain N-linked glycans, the antennae of which are composed of chito-oligomers. To our knowledge, this is the first report of such structures in a eukaryotic glycoprotein.  (+info)

Temporal recruitment of neutrophils and eosinophils to the skin in a murine model for onchocercal dermatitis. (8/208)

The parasitic helminth Onchocerca volvulus causes ocular onchocerciasis (river blindness) and onchocercal skin disease. To understand the immunologic basis for early stage skin disease, we developed a model in which C57B1/6 mice were immunized subcutaneously and injected intradermally (in the ear) with soluble O. volvulus antigens (OvAg). We found that ear thickness increased significantly after intradermal injection of OvAg and remained elevated for at least 7 days. Dermatitis was dependent on prior immunization, and was associated with an intense cellular infiltrate in the dermis. Neutrophils were the predominant inflammatory cells in the dermis 12 hr after intradermal injection, with only occasional eosinophils present. Conversely, increased ear thickness at later time points was associated with eosinophils, and neutrophils were only rarely detected. Both cell types were present at intermediate time points. These data indicate that recruitment of neutrophils and eosinophils to the skin is temporally regulated.  (+info)

'Onchocerca volvulus' is a species of parasitic roundworm that is the causative agent of human river blindness, also known as onchocerciasis. This disease is named after the fact that the larval forms of the worm are often found in the rivers and streams where the blackfly vectors breed.

The adult female worms measure about 33-50 cm in length and live in nodules beneath the skin, while the much smaller males (about 4 cm long) move between the nodules. The females release microfilariae, which are taken up by blackflies when they bite an infected person. These larvae then develop into infective stages within the blackfly and can be transmitted to another human host during a subsequent blood meal.

The infection leads to various symptoms, including itchy skin, rashes, bumps under the skin (nodules), and in severe cases, visual impairment or blindness due to damage caused to the eyes by the migrating larvae. The disease is prevalent in certain regions of Africa, Latin America, and Yemen. Preventive measures include avoiding blackfly bites, mass drug administration with anti-parasitic drugs, and vector control strategies.

Onchocerca is a genus of filarial nematode worms that are the causative agents of onchocerciasis, also known as river blindness. The most common species to infect humans is Onchocerca volvulus. These parasites are transmitted through the bite of infected blackflies (Simulium spp.) that breed in fast-flowing rivers and streams.

The adult female worms live in nodules beneath the skin, while the microfilariae, which are released by the females, migrate throughout various tissues, including the eyes, where they can cause inflammation and scarring, potentially leading to blindness if left untreated. The infection is primarily found in Africa, with some foci in Central and South America. Onchocerciasis is considered a neglected tropical disease by the World Health Organization (WHO).

Onchocerciasis is a neglected tropical disease caused by the parasitic worm Onchocerca volvulus. The infection is primarily transmitted through the bites of infected blackflies (Simulium spp.) that breed in fast-flowing rivers and streams. The larvae of the worms mature into adults in nodules under the skin, where females release microfilariae that migrate throughout the body, including the eyes.

Symptoms include severe itching, dermatitis, depigmentation, thickening and scarring of the skin, visual impairment, and blindness. The disease is also known as river blindness due to its association with riverside communities where blackflies breed. Onchocerciasis can lead to significant social and economic consequences for affected individuals and communities. Preventive chemotherapy using mass drug administration of ivermectin is the primary strategy for controlling onchocerciasis in endemic areas.

Simuliidae is a family of small, robust two-winged flies known as black flies or buffalo gnats. The term "Simuliidae" itself is the taxonomic name for this group of insects. They are called black flies because many species are dark in color, and they are often referred to as gnats or buffalo gnats due to their small size and annoying biting behavior.

Black flies are well-known for their medical significance, as they can transmit several diseases to humans and animals, including onchocerciasis (river blindness), leucocytozoonosis, and various forms of bacterial infections. The female black flies feed on blood from hosts, while males primarily feed on nectar.

These insects are typically found near bodies of water, where their larvae develop in flowing or standing waters with high oxygen levels. They have aquatic habits and undergo a complete metamorphosis during their life cycle, transforming from an egg to larva, then pupa, and finally into an adult fly.

In summary, Simuliidae is the medical term for black flies or buffalo gnats, which are small, robust two-winged flies with a medical significance due to their ability to transmit diseases to humans and animals.

Ivermectin is an anti-parasitic drug that is used to treat a variety of infections caused by parasites such as roundworms, threadworms, and lice. It works by paralyzing and killing the parasites, thereby eliminating the infection. Ivermectin is available in various forms, including tablets, creams, and solutions for topical use, as well as injections for veterinary use.

Ivermectin has been shown to be effective against a wide range of parasitic infections, including onchocerciasis (river blindness), strongyloidiasis, scabies, and lice infestations. It is also being studied as a potential treatment for other conditions, such as COVID-19, although its effectiveness for this use has not been proven.

Ivermectin is generally considered safe when used as directed, but it can cause side effects in some people, including skin rashes, nausea, and diarrhea. It should be used with caution in pregnant women and people with certain medical conditions, such as liver or kidney disease.

Intestinal volvulus is a serious medical condition that occurs when a segment of the intestine twists around itself, cutting off its blood supply. This can lead to tissue death and perforation of the intestine if not promptly treated. Intestinal volvulus can occur in any part of the intestine but is most common in the colon, particularly in the sigmoid colon.

Volvulus can be caused by a variety of factors, including congenital abnormalities, adhesions from previous surgeries, and conditions that cause the intestines to become mobile or elongated. Symptoms of intestinal volvulus may include severe abdominal pain, nausea, vomiting, bloating, and constipation. In some cases, a physical examination or imaging tests such as X-rays or CT scans may be used to diagnose the condition.

Treatment for intestinal volvulus typically involves surgery to untwist the intestine and restore blood flow. In some cases, a portion of the intestine may need to be removed if it has been damaged beyond repair. Preventative measures such as avoiding constipation and seeking prompt medical attention for abdominal pain can help reduce the risk of developing intestinal volvulus.

Microfilaria is the larval form of certain parasitic roundworms (nematodes) belonging to the family Onchocercidae. These worms include species that cause filariasis, which are diseases transmitted through the bite of infected mosquitoes or blackflies. The microfilariae are found in the blood or tissue fluids of the host and can measure from 200 to 300 microns in length. They have a distinct sheath and a characteristic tail taper, which helps in their identification under a microscope. Different filarial species have specific microfilariae characteristics, such as size, shape, and lifestyle patterns (nocturnal or diurnal periodicity). The presence of microfilariae in the host's blood or tissue fluids is indicative of an ongoing infection with the respective filarial parasite.

Onchocerciasis, Ocular is a medical condition that specifically refers to the eye manifestations caused by the parasitic infection, Onchocerca volvulus. Also known as "river blindness," this disease is spread through the bite of infected blackflies.

Ocular onchocerciasis affects various parts of the eye, including the conjunctiva, cornea, iris, and retina. The infection can cause symptoms such as itching, burning, and redness of the eyes. Over time, it may lead to more serious complications like punctate keratitis (small, scattered opacities on the cornea), cataracts, glaucoma, and ultimately, blindness.

The infection is diagnosed through a skin snip or blood test, which can detect the presence of microfilariae (the larval stage of the parasite) or antibodies against the parasite. Treatment typically involves administering oral medications such as ivermectin, which kills the microfilariae and reduces the risk of eye damage. However, it does not kill the adult worms, so multiple doses are often required to control the infection. In some cases, surgery may be necessary to remove advanced ocular lesions.

Helminth antigens refer to the proteins or other molecules found on the surface or within helminth parasites that can stimulate an immune response in a host organism. Helminths are large, multicellular parasitic worms that can infect various tissues and organs in humans and animals, causing diseases such as schistosomiasis, lymphatic filariasis, and soil-transmitted helminthiases.

Helminth antigens can be recognized by the host's immune system as foreign invaders, leading to the activation of various immune cells and the production of antibodies. However, many helminths have evolved mechanisms to evade or suppress the host's immune response, allowing them to establish long-term infections.

Studying helminth antigens is important for understanding the immunology of helminth infections and developing new strategies for diagnosis, treatment, and prevention. Some researchers have also explored the potential therapeutic use of helminth antigens or whole helminths as a way to modulate the immune system and treat autoimmune diseases or allergies. However, more research is needed to determine the safety and efficacy of these approaches.

Filaricides are a type of medication used to treat infections caused by filarial worms, which are parasitic roundworms that can infect humans and animals. These medications work by killing or inhibiting the development of the larval stages of the worms, thereby helping to eliminate the infection and prevent further transmission.

Filaricides are often used to treat diseases such as onchocerciasis (river blindness), lymphatic filariasis (elephantiasis), and loiasis (African eye worm). Examples of filaricides include ivermectin, diethylcarbamazine, and albendazole. It is important to note that these medications should only be used under the guidance of a healthcare professional, as they can have serious side effects if not used properly.

Helminth DNA refers to the genetic material found in parasitic worms that belong to the phylum Platyhelminthes (flatworms) and Nematoda (roundworms). These parasites can infect various organs and tissues of humans and animals, causing a range of diseases.

Helminths have complex life cycles involving multiple developmental stages and hosts. The study of their DNA has provided valuable insights into their evolutionary history, genetic diversity, and mechanisms of pathogenesis. It has also facilitated the development of molecular diagnostic tools for identifying and monitoring helminth infections.

Understanding the genetic makeup of these parasites is crucial for developing effective control strategies, including drug discovery, vaccine development, and disease management.

Mansonelliasis is a parasitic infection caused by the nematode (roundworm) species Mansonella perstans, M. ozzardi, or M. streptocerca. These parasites are transmitted to humans through the bite of infected blackflies or midges. The infection can cause a range of symptoms including fever, headache, pruritus (severe itching), and rash. In some cases, there may be no symptoms at all. Chronic infections can lead to more serious complications such as endocarditis, hepatomegaly (enlarged liver), and splenomegaly (enlarged spleen). However, mansonelliasis is often overlooked or misdiagnosed due to its nonspecific symptoms and the limited availability of diagnostic tests.

"Loa" is a term used in tropical medicine, specifically in the context of parasitic diseases. It refers to a type of filarial worm that can infect humans and cause a disease known as loiasis (also called "loa loa" or "African eye worm"). The Loa loa parasite is transmitted to humans through the bite of deerfly or mango fly, which acts as a vector.

The adult Loa loa worms typically reside in the subcutaneous tissue of the human host, where they can cause various symptoms such as localized itching, skin rashes, and arthralgias (joint pain). The parasite is also known to migrate through various tissues, including the eye, which can result in the appearance of a visible, moving worm under the conjunctiva. This is how loiasis earned its colloquial name "African eye worm."

Loiasis is primarily found in the rainforest regions of West and Central Africa. While not typically life-threatening on its own, loiasis can complicate the treatment of other filarial diseases such as onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis), due to potential adverse reactions to the medications used to treat these conditions.

Antibodies are proteins produced by the immune system in response to the presence of a foreign substance, known as an antigen. They are capable of recognizing and binding to specific antigens, neutralizing or marking them for destruction by other immune cells.

Helminths are parasitic worms that can infect humans and animals. They include roundworms, tapeworms, and flukes, among others. Helminth infections can cause a range of symptoms, depending on the type of worm and the location of the infection.

Antibodies to helminths are produced by the immune system in response to an infection with one of these parasitic worms. These antibodies can be detected in the blood and serve as evidence of a current or past infection. They may also play a role in protecting against future infections with the same type of worm.

There are several different classes of antibodies, including IgA, IgD, IgE, IgG, and IgM. Antibodies to helminths are typically of the IgE class, which are associated with allergic reactions and the defense against parasites. IgE antibodies can bind to mast cells and basophils, triggering the release of histamine and other inflammatory mediators that help to protect against the worm.

In addition to IgE, other classes of antibodies may also be produced in response to a helminth infection. For example, IgG antibodies may be produced later in the course of the infection and can provide long-term immunity to reinfection. IgA antibodies may also be produced and can help to prevent the attachment and entry of the worm into the body.

Overall, the production of antibodies to helminths is an important part of the immune response to these parasitic worms. However, in some cases, the presence of these antibodies may also be associated with allergic reactions or other immunological disorders.

Helminth proteins refer to the proteins that are produced and expressed by helminths, which are parasitic worms that cause diseases in humans and animals. These proteins can be found on the surface or inside the helminths and play various roles in their biology, such as in development, reproduction, and immune evasion. Some helminth proteins have been identified as potential targets for vaccines or drug development, as blocking their function may help to control or eliminate helminth infections. Examples of helminth proteins that have been studied include the antigen Bm86 from the cattle tick Boophilus microplus, and the tetraspanin protein Sm22.6 from the blood fluke Schistosoma mansoni.

I'm not aware of any medical condition or term that is specifically associated with or referred to as "Cameroon." Cameroon is a country located in Central Africa, known for its rich biodiversity and cultural diversity. If you have more context about why you are looking for a medical definition of "Cameroon," I may be able to provide a more helpful response.

Parasitic skin diseases are conditions caused by parasites living on or in the skin. These parasites can be insects, mites, or fungi that feed off of the host for their own survival. They can cause a variety of symptoms including itching, rashes, blisters, and lesions on the skin. Examples of parasitic skin diseases include scabies, lice infestations, and ringworm. Treatment typically involves the use of topical or oral medications to kill the parasites and alleviate symptoms.

Filarioidea is a superfamily of parasitic nematode (roundworm) worms, many of which are important pathogens in humans and animals. They are transmitted to their hosts through the bite of insect vectors, such as mosquitoes or flies. The filarioid worms can cause a range of diseases known as filariases. Some examples include Wuchereria bancrofti, Brugia malayi, and Onchocerca volvulus, which cause lymphatic filariasis (elephantiasis) and river blindness, respectively. The adult worms live in the lymphatic system or subcutaneous tissues of their hosts, where they produce microfilariae, the infective stage for the insect vector.

The medical definition of Filarioidea is: A superfamily of parasitic nematode worms that includes several important human pathogens and causes various filariases. The adult worms live in the lymphatic system or subcutaneous tissues, while the microfilariae are taken up by insect vectors during a blood meal and develop into infective larvae inside the vector. These larvae are then transmitted to a new host through the bite of the infected vector.

Antiparasitic agents are a type of medication used to treat parasitic infections. These agents include a wide range of drugs that work to destroy, inhibit the growth of, or otherwise eliminate parasites from the body. Parasites are organisms that live on or inside a host and derive nutrients at the host's expense.

Antiparasitic agents can be divided into several categories based on the type of parasite they target. Some examples include:

* Antimalarial agents: These drugs are used to treat and prevent malaria, which is caused by a parasite that is transmitted through the bites of infected mosquitoes.
* Antiprotozoal agents: These drugs are used to treat infections caused by protozoa, which are single-celled organisms that can cause diseases such as giardiasis, amoebic dysentery, and sleeping sickness.
* Antihelminthic agents: These drugs are used to treat infections caused by helminths, which are parasitic worms that can infect various organs of the body, including the intestines, lungs, and skin. Examples include roundworms, tapeworms, and flukes.

Antiparasitic agents work in different ways to target parasites. Some disrupt the parasite's metabolism or interfere with its ability to reproduce. Others damage the parasite's membrane or exoskeleton, leading to its death. The specific mechanism of action depends on the type of antiparasitic agent and the parasite it is targeting.

It is important to note that while antiparasitic agents can be effective in treating parasitic infections, they can also have side effects and potential risks. Therefore, it is essential to consult with a healthcare provider before starting any antiparasitic medication to ensure safe and appropriate use.

Diethylcarbamazine (DECT or DEC) is an anti-parasitic medication used to treat infections caused by roundworms, including lymphatic filariasis (elephantiasis) and river blindness (onchocerciasis). It works by killing the parasitic worms, thus helping to prevent the progression of these diseases.

Diethylcarbamazine is typically available as a prescription oral medication in the form of tablets or capsules. The dosage and duration of treatment will depend on the type and severity of the infection being treated. It's important to note that DEC should only be taken under the supervision of a healthcare professional, as it may have side effects and potential drug interactions.

Medical Citation:
"Diethylcarbamazine." National Center for Biotechnology Information. PubChem Compound Database. U.S. National Library of Medicine. . Accessed on April 18, 2023.

Anthelmintics are a type of medication used to treat infections caused by parasitic worms, also known as helminths. These medications work by either stunting the growth of the worms, paralyzing them, or killing them outright, allowing the body to expel the worms through normal bodily functions. Anthelmintics are commonly used to treat infections caused by roundworms, tapeworms, flukeworms, and hookworms. Examples of anthelmintic drugs include albendazole, mebendazole, praziquantel, and ivermectin.

Dipetalonema is a genus of parasitic nematodes (roundworms) that can infect various mammals, including humans. Two species within this genus, Dipetalonema perstans and Dipetalonema streptocerca, are known to cause human filariasis, a group of tropical diseases characterized by the presence of parasitic worms in the lymphatic system.

Dipetalonema perstans is also known as "persistent strongyloides" and can cause a condition called "tropical pulmonary eosinophilia." This species has a complex life cycle involving mosquitoes as intermediate hosts. The adult worms reside in the abdominal cavity of the human host, where they produce microfilariae that circulate in the bloodstream. When an infected mosquito takes a blood meal, it ingests the microfilariae, which then develop into infective larvae inside the mosquito. Upon subsequent bites by the mosquito, these infective larvae enter the human host and migrate to the abdominal cavity, where they mature into adults and continue the life cycle.

Dipetalonema streptocerca is primarily found in West Africa and causes a condition known as "cutaneous filariasis" or "subcutaneous filariasis." This species has a similar life cycle to D. perstans, but it involves biting midges (culicoides) instead of mosquitoes as intermediate hosts. The adult worms reside in the subcutaneous tissue, where they produce microfilariae that circulate in the skin. Infective larvae develop inside the biting midge and are transmitted to humans during blood feeding.

The symptoms of Dipetalonema infections can vary widely depending on the species and the severity of the infection. Some people may not experience any symptoms, while others may have fever, cough, wheezing, skin rashes, or lymphatic swelling (lymphedema). Treatment typically involves administration of anti-parasitic drugs such as diethylcarbamazine or ivermectin.

Mansonella is a genus of filarial nematodes (roundworms) that are transmitted to humans through the bites of infected blackflies or mosquitoes. There are several species within this genus, including M. perstans, M. ozzardi, and M. streptocerca, which can cause different clinical manifestations in humans.

Mansonella perstans is the most widespread species, found mainly in Africa and some parts of Central and South America. The adult worms reside in the abdominal cavity and the thoracic cavity, where they release microfilariae into the bloodstream. This species does not usually cause severe symptoms, but chronic infection can lead to general malaise, fatigue, and peripheral eosinophilia (high levels of eosinophils in the blood).

Mansonella ozzardi is found primarily in Central and South America, and its vectors are mosquitoes. The adult worms reside in the body cavities, subcutaneous tissues, and the peritoneal cavity. Infection with M. ozzardi can cause dermatological manifestations such as pruritus (itching), papular rash, and calcified nodules under the skin.

Mansonella streptocerca is transmitted through bites of infected midges in West and Central Africa. The adult worms live in the subcutaneous tissues, particularly around the head and neck regions, leading to pruritus, papular rash, and lymphadenopathy (swollen lymph nodes).

Diagnosis of Mansonella infections is typically made through the detection of microfilariae in blood samples, often obtained during nighttime due to the nocturnal periodicity of some species. Treatment usually involves the administration of antiparasitic drugs such as ivermectin or diethylcarbamazine.

Wolbachia is a genus of intracellular bacteria that naturally infects a wide variety of arthropods (insects, spiders, mites) and filarial nematodes (roundworms). These bacteria are transmitted vertically from mother to offspring, often through the cytoplasm of eggs. Wolbachia can manipulate the reproductive biology of their hosts in various ways, such as feminization, parthenogenesis, male killing, and cytoplasmic incompatibility, which favor the spread and maintenance of the bacteria within host populations. The interactions between Wolbachia and their hosts have implications for insect pest management, disease transmission, and evolutionary biology.

Loiasis is a tropical parasitic infection caused by the filarial nematode worm, Loa loa. It is also known as "African eye worm" due to the migration of the adult worm through the subconjunctival tissues of the eye, which is a common symptom. The infection is transmitted through the bite of deerfly or mango fly (Chrysops spp.).

After transmission, the larval form of the parasite migrates through the soft tissues and matures into an adult worm that lives in the subcutaneous tissue. Adult worms can be up to 7 cm long and may cause localized itching or a transient subconjunctival migration, which is painless but alarming to the patient.

Loiasis is usually asymptomatic, but severe symptoms such as Calabar swellings (recurrent angioedema), arthralgia, pruritus, and cardiac or respiratory complications can occur in heavy infections. Diagnosis is made by detecting microfilariae or adult worms in the blood, skin snips, or eye fluid. Treatment typically involves diethylcarbamazine citrate (DEC) therapy, but ivermectin and albendazole can also be used. Preventive measures include avoiding fly bites through the use of protective clothing, insect repellents, and bed nets.

I'm sorry for any confusion, but "Guatemala" is not a medical term or concept. It is the name of a country located in Central America. If you have any questions related to medical terminology or health-related topics, I would be happy to help with those!

I'm sorry for any confusion, but "Togo" is not a medical term. It is the name of a country in West Africa, known officially as the Togolese Republic. If you have any questions about medical terminology or health-related topics, please don't hesitate to ask!

I apologize for any confusion, but "Ecuador" is not a medical term or concept. It is the name of a country located in South America, officially known as the "República del Ecuador." If you have any questions related to medicine or health, I would be happy to try and help answer those for you!

Antinematodal agents are a type of medication used to treat infections caused by nematodes, which are also known as roundworms. These agents work by either killing the parasitic worms or preventing them from reproducing. Some examples of antinematodal agents include albendazole, ivermectin, and mebendazole. These medications are used to treat a variety of nematode infections, such as ascariasis, hookworm infection, and strongyloidiasis. It is important to note that the use of antinematodal agents should be under the guidance of a healthcare professional, as they can have side effects and may interact with other medications.

I'm sorry for any confusion, but "Liberia" is not a medical term. It is a country in West Africa, bordering the North Atlantic Ocean, between Côte d'Ivoire and Sierra Leone. Established in 1847, it was the first African republic to proclaim its independence, and is known for its unique history of being settled by freed slaves from the United States. Is there a different term or concept you would like me to define or provide information about?

Keratitis is a medical condition that refers to inflammation of the cornea, which is the clear, dome-shaped surface at the front of the eye. The cornea plays an essential role in focusing vision, and any damage or infection can cause significant visual impairment. Keratitis can result from various causes, including bacterial, viral, fungal, or parasitic infections, as well as trauma, allergies, or underlying medical conditions such as dry eye syndrome. Symptoms of keratitis may include redness, pain, tearing, sensitivity to light, blurred vision, and a feeling of something foreign in the eye. Treatment for keratitis depends on the underlying cause but typically includes antibiotics, antivirals, or anti-fungal medications, as well as measures to alleviate symptoms and promote healing.

Filariasis is a parasitic disease caused by infection with roundworms of the Filarioidea type. The infection is spread through the bite of infected mosquitoes and can lead to various symptoms depending on the type of filarial worm, including lymphatic dysfunction (elephantiasis), eye damage (onchocerciasis or river blindness), and tropical pulmonary eosinophilia. The disease is prevalent in tropical areas with poor sanitation and lack of access to clean water. Preventive measures include wearing protective clothing, using insect repellents, and sleeping under mosquito nets. Treatment typically involves the use of antiparasitic drugs such as diethylcarbamazine or ivermectin.

'Brugia malayi' is a species of parasitic nematode (roundworm) that can infect humans and cause the tropical disease known as lymphatic filariasis. The adult worms typically reside in the lymphatic vessels, where they can cause inflammation, obstruction, and damage to the lymphatic system.

The life cycle of 'Brugia malayi' involves several stages, including microfilariae (immature worms) that are transmitted to a human host through the bite of an infected mosquito vector. Once inside the human body, the microfilariae migrate to the lymphatic vessels and mature into adult worms over a period of several months.

The symptoms of lymphatic filariasis can range from mild to severe, depending on the extent of the infection and the individual's immune response. In some cases, the disease can lead to chronic swelling and deformity of the affected limbs or genitalia, a condition known as elephantiasis.

Preventive measures for lymphatic filariasis include avoiding mosquito bites through the use of insect repellent, long-sleeved clothing, and bed nets, as well as mass drug administration programs to eliminate the parasite from affected communities.

I'm sorry for any confusion, but "Guinea" is not a medical term. It is a geographical term referring to a region on the west coast of Africa, as well as the country of Equatorial Guinea and its neighboring countries. Additionally, "Guinea" can also refer to a unit of currency in Liberia.

If you have any medical concerns or questions, I would be happy to try to help answer them for you.

Setaria nematodes are a type of roundworm that belongs to the family Setariidae. These parasitic worms primarily infect birds, but some species can also infect mammals, including humans. The most common Setaria nematode that infects humans is Setaria digitata, which is found mainly in Asia and is transmitted through the consumption of raw or undercooked freshwater snails or fish.

In humans, Setaria nematodes typically cause mild symptoms or are asymptomatic. However, in some cases, they can lead to the development of eosinophilic meningitis, an inflammation of the membranes surrounding the brain and spinal cord, which can cause headaches, stiff neck, fever, and other neurological symptoms.

Setaria nematodes have a complex life cycle that involves several hosts, including snails, fish, and birds. Humans can become accidental hosts when they ingest infective larvae present in contaminated food or water. Once inside the human body, the larvae migrate to various tissues, such as the brain, eyes, or subcutaneous tissue, where they mature into adults and produce eggs. The eggs are then excreted from the body through feces or other bodily fluids.

Preventing Setaria nematode infections involves avoiding the consumption of raw or undercooked freshwater snails or fish and practicing good hygiene, such as washing hands thoroughly before eating or preparing food. In cases where infection occurs, treatment typically involves administering anthelmintic drugs to kill the worms and alleviate symptoms.

Wuchereria bancrofti is a parasitic roundworm that causes lymphatic filariasis, also known as elephantiasis. It is transmitted to humans through the bite of infected mosquitoes. The worms infect the lymphatic system and can lead to chronic swelling of body parts such as the limbs, breasts, and genitals, as well as other symptoms including fever, chills, and skin rashes. Wuchereria bancrofti is a significant public health problem in many tropical and subtropical regions around the world.

"Western Africa" is a geographical region that consists of several countries located in the western part of the African continent. The United Nations defines Western Africa as the 16 countries of Benin, Burkina Faso, Cape Verde, Gambia, Ghana, Guinea, Guinea-Bissau, Ivory Coast, Liberia, Mali, Mauritania, Niger, Nigeria, Senegal, Sierra Leone, and Togo.

The region is characterized by a diverse range of cultures, languages, and ethnic groups, as well as a variety of landscapes, including coastal areas, savannas, and deserts. Western Africa has a rich history, with many ancient kingdoms and empires having existed in the region, such as the Ghana Empire, Mali Empire, and Songhai Empire.

In medical contexts, "Western Africa" may be used to describe the epidemiology, distribution, or characteristics of various health conditions or diseases that are prevalent in this geographical region. For example, certain infectious diseases such as malaria, HIV/AIDS, and Ebola virus disease are more common in Western Africa than in other parts of the world. Therefore, medical researchers and practitioners may use the term "Western Africa" to refer to the specific health challenges and needs of the populations living in this region.

Insect vectors are insects that transmit disease-causing pathogens (such as viruses, bacteria, parasites) from one host to another. They do this while feeding on the host's blood or tissues. The insects themselves are not infected by the pathogen but act as mechanical carriers that pass it on during their bite. Examples of diseases spread by insect vectors include malaria (transmitted by mosquitoes), Lyme disease (transmitted by ticks), and plague (transmitted by fleas). Proper prevention measures, such as using insect repellent and reducing standing water where mosquitoes breed, can help reduce the risk of contracting these diseases.

'Insect control' is not a term typically used in medical definitions. However, it generally refers to the methods and practices used to manage or reduce the population of insects that can be harmful or disruptive to human health, food supply, or property. This can include various strategies such as chemical pesticides, biological control agents, habitat modification, and other integrated pest management techniques.

In medical terms, 'vector control' is a more relevant concept, which refers to the specific practices used to reduce or prevent the transmission of infectious diseases by insects and other arthropods that act as disease vectors (such as mosquitoes, ticks, and fleas). Vector control measures may include the use of insecticides, larvicides, biological control agents, environmental management, personal protection methods, and other integrated vector management strategies.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

Cecal diseases refer to medical conditions that affect the cecum, which is a pouch-like structure located at the junction of the small and large intestines. The cecum plays an important role in digestion, particularly in the fermentation of certain types of food.

There are several different types of cecal diseases, including:

1. Cecal volvulus: This is a rare condition in which the cecum twists on itself, cutting off blood flow and causing severe pain and other symptoms.
2. Diverticulitis: This occurs when small pouches called diverticula form in the wall of the cecum and become inflamed or infected.
3. Appendicitis: Although not strictly a cecal disease, the appendix is a small tube-like structure that branches off from the cecum. Inflammation of the appendix (appendicitis) can cause severe pain in the lower right abdomen and may require surgical removal of the appendix.
4. Crohn's disease: This is a chronic inflammatory bowel disease that can affect any part of the digestive tract, including the cecum.
5. Tuberculosis: The cecum can also be affected by tuberculosis, which is a bacterial infection that primarily affects the lungs but can spread to other parts of the body.
6. Cancer: Although rare, cancer can also affect the cecum, leading to symptoms such as abdominal pain, bloating, and changes in bowel habits.

Treatment for cecal diseases depends on the specific condition and its severity. Treatment options may include antibiotics, surgery, or other medical interventions. If you are experiencing symptoms that may be related to a cecal disease, it is important to seek medical attention promptly.

A larva is a distinct stage in the life cycle of various insects, mites, and other arthropods during which they undergo significant metamorphosis before becoming adults. In a medical context, larvae are known for their role in certain parasitic infections. Specifically, some helminth (parasitic worm) species use larval forms to infect human hosts. These invasions may lead to conditions such as cutaneous larva migrans, visceral larva migrans, or gnathostomiasis, depending on the specific parasite involved and the location of the infection within the body.

The larval stage is characterized by its markedly different morphology and behavior compared to the adult form. Larvae often have a distinct appearance, featuring unsegmented bodies, simple sense organs, and undeveloped digestive systems. They are typically adapted for a specific mode of life, such as free-living or parasitic existence, and rely on external sources of nutrition for their development.

In the context of helminth infections, larvae may be transmitted to humans through various routes, including ingestion of contaminated food or water, direct skin contact with infective stages, or transmission via an intermediate host (such as a vector). Once inside the human body, these parasitic larvae can cause tissue damage and provoke immune responses, leading to the clinical manifestations of disease.

It is essential to distinguish between the medical definition of 'larva' and its broader usage in biology and zoology. In those fields, 'larva' refers to any juvenile form that undergoes metamorphosis before reaching adulthood, regardless of whether it is parasitic or not.

I'm sorry for any confusion, but "Mexico" is not a medical term or concept. It is the name of a country located in North America. If you have any questions related to medical topics, I would be happy to try and help answer those for you.

Intestinal obstruction, also known as bowel obstruction, is a medical condition characterized by a blockage that prevents the normal flow of contents through the small intestine or large intestine (colon). This blockage can be caused by various factors such as tumors, adhesions (scar tissue), hernias, inflammation, or impacted feces.

The obstruction can be mechanical, where something physically blocks the intestinal lumen, or functional, where the normal muscular contractions of the bowel are impaired. Mechanical obstructions are more common than functional ones.

Symptoms of intestinal obstruction may include abdominal pain and cramping, nausea and vomiting, bloating, inability to pass gas or have a bowel movement, and abdominal distention. If left untreated, intestinal obstruction can lead to serious complications such as tissue death (necrosis), perforation of the intestine, and sepsis. Treatment typically involves hospitalization, intravenous fluids, nasogastric decompression, and possibly surgery to remove the obstruction.

I'm sorry for any confusion, but "Ghana" is not a medical term. It is the name of a country located in West Africa, known officially as the Republic of Ghana. If you have any questions about medical terms or conditions, I would be happy to help with those!

An endemic disease is a type of disease that is regularly found among particular people or in a certain population, and is spread easily from person to person. The rate of infection is consistently high in these populations, but it is relatively stable and does not change dramatically over time. Endemic diseases are contrasted with epidemic diseases, which suddenly increase in incidence and spread rapidly through a large population.

Endemic diseases are often associated with poverty, poor sanitation, and limited access to healthcare. They can also be influenced by environmental factors such as climate, water quality, and exposure to vectors like mosquitoes or ticks. Examples of endemic diseases include malaria in some tropical countries, tuberculosis (TB) in many parts of the world, and HIV/AIDS in certain populations.

Effective prevention and control measures for endemic diseases typically involve improving access to healthcare, promoting good hygiene and sanitation practices, providing vaccinations when available, and implementing vector control strategies. By addressing the underlying social and environmental factors that contribute to the spread of these diseases, it is possible to reduce their impact on affected populations and improve overall health outcomes.

Interleukin-5 (IL-5) is a type of cytokine, which is a small signaling protein that mediates and regulates immunity, inflammation, and hematopoiesis. IL-5 is primarily produced by activated T cells, especially Th2 cells, as well as mast cells, eosinophils, and innate lymphoid cells (ILCs).

The primary function of IL-5 is to regulate the growth, differentiation, activation, and survival of eosinophils, a type of white blood cell that plays a crucial role in the immune response against parasitic infections. IL-5 also enhances the ability of eosinophils to migrate from the bone marrow into the bloodstream and then into tissues, where they can participate in immune responses.

In addition to its effects on eosinophils, IL-5 has been shown to have a role in the regulation of B cell function, including promoting the survival and differentiation of B cells into antibody-secreting plasma cells. Dysregulation of IL-5 production and activity has been implicated in several diseases, including asthma, allergies, and certain parasitic infections.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Glomerulonephritis is a medical condition that involves inflammation of the glomeruli, which are the tiny blood vessel clusters in the kidneys that filter waste and excess fluids from the blood. This inflammation can impair the kidney's ability to filter blood properly, leading to symptoms such as proteinuria (protein in the urine), hematuria (blood in the urine), edema (swelling), hypertension (high blood pressure), and eventually kidney failure.

Glomerulonephritis can be acute or chronic, and it may occur as a primary kidney disease or secondary to other medical conditions such as infections, autoimmune disorders, or vasculitis. The diagnosis of glomerulonephritis typically involves a combination of medical history, physical examination, urinalysis, blood tests, and imaging studies, with confirmation often requiring a kidney biopsy. Treatment depends on the underlying cause and severity of the disease but may include medications to suppress inflammation, control blood pressure, and manage symptoms.

Pharyngitis is the medical term for inflammation of the pharynx, which is the back portion of the throat. This condition is often characterized by symptoms such as sore throat, difficulty swallowing, and scratchiness in the throat. Pharyngitis can be caused by a variety of factors, including viral infections (such as the common cold), bacterial infections (such as strep throat), and irritants (such as smoke or chemical fumes). Treatment for pharyngitis depends on the underlying cause of the condition, but may include medications to relieve symptoms or antibiotics to treat a bacterial infection.

Streptococcal infections are a type of infection caused by group A Streptococcus bacteria (Streptococcus pyogenes). These bacteria can cause a variety of illnesses, ranging from mild skin infections to serious and potentially life-threatening conditions such as sepsis, pneumonia, and necrotizing fasciitis (flesh-eating disease).

Some common types of streptococcal infections include:

* Streptococcal pharyngitis (strep throat) - an infection of the throat and tonsils that can cause sore throat, fever, and swollen lymph nodes.
* Impetigo - a highly contagious skin infection that causes sores or blisters on the skin.
* Cellulitis - a bacterial infection of the deeper layers of the skin and underlying tissue that can cause redness, swelling, pain, and warmth in the affected area.
* Scarlet fever - a streptococcal infection that causes a bright red rash on the body, high fever, and sore throat.
* Necrotizing fasciitis - a rare but serious bacterial infection that can cause tissue death and destruction of the muscles and fascia (the tissue that covers the muscles).

Treatment for streptococcal infections typically involves antibiotics to kill the bacteria causing the infection. It is important to seek medical attention if you suspect a streptococcal infection, as prompt treatment can help prevent serious complications.

Streptococcus pyogenes is a Gram-positive, beta-hemolytic streptococcus bacterium that causes various suppurative (pus-forming) and nonsuppurative infections in humans. It is also known as group A Streptococcus (GAS) due to its ability to produce the M protein, which confers type-specific antigenicity and allows for serological classification into more than 200 distinct Lancefield groups.

S. pyogenes is responsible for a wide range of clinical manifestations, including pharyngitis (strep throat), impetigo, cellulitis, erysipelas, scarlet fever, rheumatic fever, and acute poststreptococcal glomerulonephritis. In rare cases, it can lead to invasive diseases such as necrotizing fasciitis (flesh-eating disease) and streptococcal toxic shock syndrome (STSS).

The bacterium is typically transmitted through respiratory droplets or direct contact with infected skin lesions. Effective prevention strategies include good hygiene practices, such as frequent handwashing and avoiding sharing personal items, as well as prompt recognition and treatment of infections to prevent spread.

Rheumatic fever is a systemic inflammatory disease that may occur following an untreated Group A streptococcal infection, such as strep throat. It primarily affects children between the ages of 5 and 15, but it can occur at any age. The condition is characterized by inflammation in various parts of the body, including the heart (carditis), joints (arthritis), skin (erythema marginatum, subcutaneous nodules), and brain (Sydenham's chorea).

The onset of rheumatic fever usually occurs 2-4 weeks after a streptococcal infection. The exact cause of the immune system's overreaction leading to rheumatic fever is not fully understood, but it involves molecular mimicry between streptococcal antigens and host tissues.

The Jones Criteria are used to diagnose rheumatic fever, which include:

1. Evidence of a preceding streptococcal infection (e.g., positive throat culture or rapid strep test, elevated or rising anti-streptolysin O titer)
2. Carditis (heart inflammation), including new murmurs or changes in existing murmurs, electrocardiogram abnormalities, or evidence of heart failure
3. Polyarthritis (inflammation of multiple joints) – typically large joints like the knees and ankles, migratory, and may be associated with warmth, swelling, and pain
4. Erythema marginatum (a skin rash characterized by pink or red, irregularly shaped macules or rings that blanch in the center and spread outward)
5. Subcutaneous nodules (firm, round, mobile lumps under the skin, usually over bony prominences)
6. Sydenham's chorea (involuntary, rapid, irregular movements, often affecting the face, hands, and feet)

Treatment of rheumatic fever typically involves antibiotics to eliminate any residual streptococcal infection, anti-inflammatory medications like corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs) to manage symptoms and prevent long-term heart complications, and secondary prophylaxis with regular antibiotic administration to prevent recurrent streptococcal infections.

Membranoproliferative Glomerulonephritis (MPGN) is a type of glomerulonephritis, which is a group of kidney disorders characterized by inflammation and damage to the glomeruli, the tiny blood vessels in the kidneys responsible for filtering waste and excess fluids from the blood.

MPGN is specifically characterized by thickening of the glomerular basement membrane and proliferation (increased number) of cells in the mesangium, a region within the glomerulus. This condition can be primary or secondary to other diseases such as infections, autoimmune disorders, or monoclonal gammopathies.

MPGN is typically classified into three types based on the pattern of injury seen on electron microscopy: Type I, Type II (Dense Deposit Disease), and Type III. Each type has distinct clinical features, laboratory findings, and treatment approaches. Symptoms of MPGN may include hematuria (blood in urine), proteinuria (protein in urine), hypertension (high blood pressure), edema (swelling), and eventually progress to chronic kidney disease or end-stage renal disease if left untreated.

Penicillin V, also known as Penicillin V Potassium, is an antibiotic medication used to treat various bacterial infections. It belongs to the class of medications called penicillins, which work by interfering with the bacteria's ability to form a protective covering (cell wall), causing the bacteria to become more susceptible to destruction by the body's immune system.

Penicillin V is specifically used to treat infections of the respiratory tract, skin, and ear. It is also used to prevent recurrent rheumatic fever and chorea (Sydenham's chorea), a neurological disorder associated with rheumatic fever.

The medication is available as oral tablets or liquid solutions and is typically taken by mouth every 6 to 12 hours, depending on the severity and type of infection being treated. As with any antibiotic, it is important to take Penicillin V exactly as directed by a healthcare professional and for the full duration of treatment, even if symptoms improve before all doses have been taken.

Penicillin V is generally well-tolerated, but like other penicillins, it can cause allergic reactions in some people. It may also interact with certain medications, so it is important to inform a healthcare provider of any other medications being taken before starting Penicillin V therapy.

... is a filarial (arthropod-borne) nematode (roundworm) that causes onchocerciasis (river blindness), and is ... John O'Neill, an Irish surgeon, first described Onchocerca volvulus in 1874, when he found it to be the causative agent of ' ... Greene, B.M.; Gbakima, A.A.; Albiez, E.J.; Taylor, H.R. (1985). "Humoral and cellular immune responses to Onchocerca volvulus ... "Onchocerca volvulus". NCBI Taxonomy Browser. 6282. (CS1 Dutch-language sources (nl), Articles with short description, Short ...
Onchocerca ochengi, the closest relative of O. volvulus, lives in intradermal cavities in cattle, and is also spread by black ... 2010). "Lack of Onchocerca volvulus transmission in the northern focus in Chiapas". Am. J. Trop. Med. Hyg. 83 (1): 15-20. doi: ... The Onchocerca volvulus main habitat is fast flowing rivers, Onchocerciasis is more commonly found along the large rivers in ... Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (June 2007). "Prevalence and intensity of Onchocerca volvulus ...
... with a relatively high level of infection by the parasitic worm Onchocerca volvulus, the causative agent of river blindness. ... "The Effects of Drugs on Onchocerca volvulus: 4. Trials of Melarsonyl Potassium". World Health Organization Bulletin. 42 (1): ...
Onchocercal keratitis, which follows Onchocerca volvulus infection by infected blackfly bite. These blackfly, Simulium, usually ...
ISBN 978-3-662-00226-1. Duke, BO (1968). "Reinfections with Onchocerca volvulus in cured patients exposed to continuing ... Premunity occurs in infections of babesiosis, malaria Onchocerca volvulus, and Trichomonas. Herd immunity Adaptive immune ...
The other two are Mansonella streptocerca and Onchocerca volvulus (causes river blindness). Maturing larvae and adults of the " ... and Onchocerca volvulus in rain forest villages of Cameroon". Medical Microbiology and Immunology. 192 (1): 15-21. doi:10.1007/ ...
Examination of skin snips will identify microfilariae of Onchocerca volvulus and M. streptocerca. Skin snips can be obtained ... Additionally, to differentiate the skin-dwelling filariae M. streptocerca and Onchocerca volvulus, a nested polymerase chain ... "The morphological discrimination of microfilariae of Onchocerca volvulus from Mansonella ozzardi" (PDF). Parasitology. 127 (Pt ...
... yet unlike other Black flies these species are not carriers of Onchocerca volvulus. List of Ethiopian rivers Schütt, Brigitta, ...
Onchocerca volvulus] is involved in some way, but it is a little puzzling because [the worm] is fairly common in areas that do ... "We could not establish any hint that Onchocerca volvulus is actually going into the brain, but what we cannot exclude is that ... but it is believed to be connected to infestations of the parasitic worm Onchocerca volvulus, which is prevalent in all ... "Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus". Science Translational Medicine. 9 ( ...
... a disease caused by the parasitic worm Onchocerca volvulus. In a 2017 publication in the journal Science Translational Medicine ... "Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus". Science Translational Medicine. 9 ( ... Nath and colleagues implicated an autoimmune reaction to O. volvulus as a potential cause of the disease. In 2012, Nath was ...
... and Onchocerca volvulus. These worms occupy the layer just under the skin. L. loa causes Loa loa filariasis, while O. volvulus ... Onchocerca volvulus manifests itself in the eyes, causing "river blindness" (onchocerciasis), one of the leading causes of ... Some filarial worms, such as M. streptocerca and O. volvulus, produce microfilariae that do not use the blood; they reside in ... O. ochengi is closely related to human O. volvulus (river blindness), sharing the same vector, and could be useful in human ...
... the Onchocerca volvulus, Necator americanus, Wuchereria bancrofti and Dracunculus medinensis are human parasites. Some of ...
... double-blind study of moxidectin in Onchocerca volvulus infection". PLOS Neglected Tropical Diseases. 8 (6): e2953. doi:10.1371 ...
Irvine M, Huima T, Prince AM, Lustigman S (May 1994). "Identification and characterization of an Onchocerca volvulus cDNA clone ... and an Onchocerca volvulus antigen. Goetinck S, Waterston RH (October 1994). "The Caenorhabditis elegans muscle-affecting gene ...
The other two filarial nematodes are Loa loa (the African eye worm), and Onchocerca volvulus (river blindness). The worm is ... or ocular infections like that of Onchocerca volvulus. Due to the absence of nodules, differentiating between M. streptocerca ...
A public health study in 1998 found significant presence of Onchocerca volvulus in the local government area. "Tudun Wada LGA ...
Onchocerca volvulus infection promotes immunosuppressive processes within the human host that suppress immunity against ... Because O. volvulus microfilariae require at least seven days to mature into infective L3 larvae in the black fly, the worm ...
M. ozzardi is usually smaller than those Onchocerca Volvulus (that causes human onchocerciasis) when both species co-exist; ... Characterization of Nuclear Ribosomal DNA Sequences from Onchocera volvulus and Mansonella ozzardi (Nematoda: Filarioidea) and ... volvulus co-occur, skin biopsies have always showed that onchoserciasis is the cause for corneal lesions. Microscopic ...
A study examining the epidemiology of Loa loa, Onchocerca volvulus, and M. perstans in the rain forest villages of Cameroon ... Wolbachiae are bacterial endosymbionts of insects and many filarial nematodes, such as Onchocerca volvulus, Wuchereria ... and Onchocerca volvulus in rain forest villages of Cameroon". Medical Microbiology and Immunology. 192 (1): 15-21. doi:10.1007/ ...
Black flies are central to the transmission of the parasitic nematode Onchocerca volvulus which causes onchocerciasis, or " ...
Onchocerca volvulus causes cutaneous onchocerciasis and river blindness The other two are less seriously pathogenic but ...
It is caused by the nematode Onchocerca volvulus, which is transmitted to people via the bite of a black fly. The current WHO ...
An extract of the stem bark proved to be toxic to microfilariae of Onchocerca volvulus, the cause of river blindness. ...
Onchocerca volvulus Transmission Has Been Eliminated from the Central Endemic Zone". The American Journal of Tropical Medicine ... correctly attributing it to infection with Onchocerca volvulus parasites. He discerned the etiology from clinical observations ... Puente Rodolfo Robles Fee, W. T. (September 1919). "The Epidemic of Filaria-Onchocerca". California State Journal of Medicine. ...
The river is home to Onchocerca volvulus, the parasite that causes Onchocerciasis, which causes blindness and is a serious ...
It was not until 1985 ivermectin was first used to treat infections with Onchocerca volvulus (onchocerciasis or river blindness ...
Duke BO, Marty AM, Peett DL, Gardo J, Pion SD, Kamgno J, Boussinesq M. Neoplastic change in Onchocerca volvulus and its ... Marty in developing various infectious disease conferences and in identifying unusual effects caused in the female Onchocerca ...
Ov-FAR-1, which is produced by the riverblindness parasite Onchocerca volvulus binds retinol with great affinity, and this ...
... main Onchocerca volvulus vector within the highland areas of the Amazonia onchocerciasis focus". Acta Tropica. 131: 49, 51. doi ...
... nearly 13,000 flies over an area of 1000 square miles and dissecting 1200 flies to check for larvae of Onchocerca volvulus. ...
Onchocerca volvulus is a filarial (arthropod-borne) nematode (roundworm) that causes onchocerciasis (river blindness), and is ... John ONeill, an Irish surgeon, first described Onchocerca volvulus in 1874, when he found it to be the causative agent of ... Greene, B.M.; Gbakima, A.A.; Albiez, E.J.; Taylor, H.R. (1985). "Humoral and cellular immune responses to Onchocerca volvulus ... "Onchocerca volvulus". NCBI Taxonomy Browser. 6282. (CS1 Dutch-language sources (nl), Articles with short description, Short ...
A genomic comparison of 27 global isolates of Onchocerca volvulus, the agent of river blindness, elucidates its evolutionary ... We describe O. volvulus genome variation in 27 isolates from the early 1990s (before widespread mass treatment) from four ... Ongoing elimination efforts have altered the global distribution of Onchocerca volvulus, the agent of river blindness, and ...
... volvulus infection may persist for years. To investigate the effect of residual adult filaria on the … ... of Onchocerca volvulus from skin and eyes of onchocerciasis patients while adult filaria remains alive and reproductive, and ... Chemokines and cytokines in patients with an occult Onchocerca volvulus infection Microbes Infect. 2012 May;14(5):438-46. doi: ... Repeated ivermectin treatment will clear microfilaria (Mf) of Onchocerca volvulus from skin and eyes of onchocerciasis patients ...
... volvulus infective 3rd-stage larvae (L3) and anthropometric factors may influence the acquisition, development and persistence ... This study analysed the impact and the extent by which parental Onchocerca volvulus infection, intensity of transmission of O. ... of O. volvulus infection in offspring. A total … ... volvulus, and prevalence and level of O. volvulus infection in ... This study analysed the impact and the extent by which parental Onchocerca volvulus infection, intensity of transmission of O. ...
Animals Antibodies, Helminth Diagnostic Tests, Routine Enzyme-Linked Immunosorbent Assay Humans Onchocerca Volvulus ... Serological assays for human IgG4 to the Onchocerca volvulus antigen Ov16 have been used to confirm elimination of ... "A Recombinant Positive Control for Serology Diagnostic Tests Supporting Elimination of Onchocerca volvulus" 10, no. 1 (2016). ... A Recombinant Positive Control for Serology Diagnostic Tests Supporting Elimination of Onchocerca volvulus. ...
Onchocerca volvulus. Like the deer fly and loa loa worm, the worm-like Onchocerca volvulus parasite is passed to a new host ...
Motile Onchocerca volvulus Microfilariae in the Anterior Chamber of the Eye Michael E. Gyasi ...
... Author: Manchang, T. ... Immune recognition of Onchocerca volvulus proteins in the human host and animal models of onchocerciasis. DSpace Repository. ...
Onchocerca volvulus. Syphilis. Trichinella spiralis. SARS-CoV-2 (COVID-19). Fungal. Histoplasma capsulatum. ...
Onchocerca volvulus, a filarial nematode, causes onchocerciasis, also known as river blindness. ... volvulus adult worm and for embryogenesis. Individuals at risk for co-infection with Loa loa should have blood evaluated to ...
Parasite Antigens Are Present in Breast Milk of Women Infected with Onchocerca volvulus ...
A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the ... A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the ... A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the ... A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the ...
ABSTRACT A study on the assessment of Onchocercavolvulus infection in humans and blackflies and the onchocerciasis response to ... Project Title: ASSESSMENTS OF ONCHOCERCA VOLVULUS INFECTION IN HUMANS AND BLACKFLIES AND ONCHOCERCIASIS RESPONSE TO IVERMECTIN ... ASSESSMENTS OF ONCHOCERCA VOLVULUS INFECTION IN HUMANS AND BLACKFLIES AND ONCHOCERCIASIS RESPONSE TO IVERMECTIN AMONG VILLAGERS ... Complete Project Topic Material(s) for ASSESSMENTS OF ONCHOCERCA VOLVULUS INFECTION IN HUMANS AND BLACKFLIES AND ONCHOCERCIASIS ...
Dive into the research topics of Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and ... T1 - Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter ... Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter ... Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter ...
Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus.. Tory P. Johnson, Richa Tyagi, Paul R ... Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Tory P. Johnson, Richa Tyagi, Paul R ... Detection of Onchocerca volvulus in Skin Snips by Microscopy and Real-Time Polymerase Chain Reaction: Implications for ... The emergence of zoonotic onchocerca lupi infection in the United States-a case-series. Paul T. Cantey, Jessica Weeks, Morven ...
Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial. Lancet. ... Moxidectin, a macrocyclic lactone, is an anthelmintic indicated for the treatment of onchocerciasis due to Onchocerca volvulus ... Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of ... Ocular zoonotic onchocerca infection in a resident of Oregon. Am J Trop Med Hyg. 2012 Dec. 87(6):1073-5. [QxMD MEDLINE Link]. [ ...
Onchocerca volvulus: A0A044TMQ9; Brugia pahangi: A0A0N4TLS2; Brugia malayi: A0A4E9FFK1, A0A0K0JD75; Acanthocheilonema viteae: ... Onchocerca ochengi: A0A182EJC5; Litomosoides sigmodontis: A0A3P6U6X0; Brugia timori: A0A0R3Q8V2; Phocoena sinus: A0A8C9B3Q4; ... Onchocerca flexuosa: A0A238BX73; Alligator sinensis: A0A1U7RE43; Phascolarctos cinereus: A0A6P5LL69; Orthonyx spaldingii: ...
Categories: Onchocerca volvulus Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
cyclophilin Ovcyp-2 [Onchocerca volvulus]. Match: gi,11270316,pir,,T50768. score: 202.6. e-value: 7.5e-51. Identity: 60.23%. ...
onchocerciasis, filarial disease caused by the helminth Onchocerca volvulus, which is transmitted to humans by...... ...
Onchocerciasis: Onchocerca volvulus infects 20 million people in West, Central, and East Africa and another 1 million people in ... Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis. Lancet Infect Dis. 2008 May. 8( ...
When it progresses, Onchocerca volvulus microfilariae concentrate on eyeballs, which can lead to eye lesions, and if left ... 2 It is caused by the parasitic worm Onchocerca volvulus. It is transmitted through repeated bites by black flies of the genus ...
Onchocerca volvulus Strongyloides stercoralis Trichinella spiralis Trichuris trichiura Wuchereria bancrofti Animal Parasitic ... Onchocerca ochengi Onchocerca flexuosa Ostertagia ostertagi Parastrongyloides trichosuri Strongyloides ratti Teladorsagia ...
... streptocerca from Onchocerca volvulus in skin snips. In research settings, real-time PCR (RT-PCR) assays can be used to detect ... and should be thus distinguished from Wuchereria bancrofti and Onchocerca volvulus. ... and should be distinguished from those of Onchocerca volvulus. ...
Quantitative studies on the transmission of Onchocerca volvulus by Simulium damnosum in the Bong Range, Liberia 1973 Bernhard ... volvulus, and 3.0% third stage larvae of other filaria species. An average of 900 O. volvulus larvae theoretically transmitted ... Quantitative aspects of the transmission of O. volvulus have been investigated in an area of the tropical rain forest zone in ... volvulus. The infection was determined by a standardized skin biopsy technique (Walser punch). At the age of 16 to 18 yr more ...
Onchocerca volvulus. 433. Opisthorchis viverrini. 434. Paecilomyces lilacinus (Purpureocillium lilacinum). 526. Paecilomyces ...
The worm (Onchocerca volvulus) is transmitted to humans as immature larvae through bites of infected black flies. Symptoms of ... Onchocerciasis a parasitic disease is caused by the filarial worm Onchocerca volvulus. Onchocerciasis is also ... ... In the new study, 16,259 volunteers in 92 villages in Cameroon where both L. loa and O. volvulus are commonly found provided ...
Moreover there seems to be an association between epilepsy and the degree of infection with Onchocerca volvulus. Indeed, in a ...
Onchocerca volvulus, the infectious agent of onchocerciasis. We therefore sought to determine whether antibodies produced by ... and the lambda Ral-1 antigen of Onchocerca volvulus.. ... In addition, a monoclonal antibody raised against O. volvulus ... and the lambda Ral-1 antigen of Onchocerca volvulus.. ... volvulus might play a triggering or exacerbating role in the ...
  • Onchocerca volvulus is a filarial (arthropod-borne) nematode (roundworm) that causes onchocerciasis (river blindness), and is the second-leading cause of blindness due to infection worldwide after trachoma. (wikipedia.org)
  • Two highly similar genes encoding unique extracellular, glycosylated glutathione S-transferases (GSTs) of the human-pathogenic nematode, Onchocerca volvulus (Ov-GST1a and Ov-GST1b), have been isolated and characterised. (aber.ac.uk)
  • The sequence of this 46-kD Ro/SS-A protein (calreticulin) has significant homology to lambda Ral-1, a recombinant cDNA clone corresponding to a major antigen of the nematode, Onchocerca volvulus, the infectious agent of onchocerciasis. (jci.org)
  • Onchocerciasis (river blindness) is a neglected tropical parasitic disease (NTD) caused by a filarial nematode worm called Onchocerca volvulus encapsulated in nodules under the skin. (hindawi.com)
  • Loa loa is a member of the filarial nematode (roundworm) family, which also includes worms that cause river blindness ( Onchocerca volvulus ) and elephantiasis ( Wuchereria bancrofti ). (broadinstitute.org)
  • STROMECTOL is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis and for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus . (yahoo.com)
  • Onchocerciasis (pronounced /ˈɒŋkɵsɜrˈsaɪ.əsɨs/ or /ˈɒŋkɵsɜrˈkaɪ.əsɨs/), also known as river blindness and Robles' Disease, is a parasitic disease caused by infection with the nematode Onchocerca volvulus. (openlinksw.com)
  • The microfilariae of O. volvulus are found in the dermis layer of skin in the host. (wikipedia.org)
  • The microfilariae are taken up by a female blackfly when it takes a blood meal, thus completing the lifecycle of O. volvulus. (wikipedia.org)
  • A total of 15290 individuals in 3939 families with 9640 children were surveyed for microfilariae of O. volvulus, and prevalence and level of O. volvulus infection in children aged 0 to 20 years from infected and non-infected parents were followed longitudinally for 18 years. (nih.gov)
  • Concurrent administration of corticosteroids should be considered with DEC treatment to minimize the allergic manifestations secondary to the disintegration of microfilariae, particularly in O volvulus and L loa infections. (medscape.com)
  • The survey result revealed that none of the study participants regardless of age, sex, and location demonstrated skin snip Onchocerca microfilariae. (hindawi.com)
  • Female Onchocerca volvulus worms produce thousands of microfilariae which exit the nodules, move into the dermis, and enter the eye causing cutaneous and eye disease [ 1 , 2 ]. (hindawi.com)
  • The morphological discrimination of microfilariae of Onchocerca volvulus from Mansonella ozzardi. (lshtm.ac.uk)
  • There is no published account which allows the morphological discrimination of microfilariae of Onchocerca volvulus and M. ozzardi from each other. (lshtm.ac.uk)
  • O. volvulus causes onchocerciasis, which causes severe itching. (wikipedia.org)
  • Repeated ivermectin treatment will clear microfilaria (Mf) of Onchocerca volvulus from skin and eyes of onchocerciasis patients while adult filaria remains alive and reproductive, and such occult O. volvulus infection may persist for years. (nih.gov)
  • To investigate the effect of residual adult filaria on the immune response profile, chemokines and cytokines were quantified 1) in onchocerciasis patients who developed an occult O. volvulus infection (Mf-negative) due to repeated ivermectin treatments, 2) patients who became Mf-negative without ivermectin treatments due to missing re-infection, and 3) endemic and non-endemic O. volvulus Mf-negative controls. (nih.gov)
  • Longitudinal follow up of children showed that during vector control activities by the Onchocerciasis Control Programme (OCP) and in low-level transmission areas, infection persisted at higher levels in children from O. volvulus-positive mothers. (nih.gov)
  • In summary, the dominant risk factor for children to become infected is maternal onchocerciasis, and also age-associated factors will strongly impact on the development of patent O. volvulus infection in offspring. (nih.gov)
  • NOTE: By purchasing this "ASSESSMENTS OF ONCHOCERCA VOLVULUS INFECTION IN HUMANS AND BLACKFLIES AND ONCHOCERCIASIS RESPONSE TO IVERMECTIN AMONG VILLAGERS AROUND GURARA DAM, KADUNA STATE, NIGERIA" CodeMint project, it means you have read and agreed to our Terms of Use and our Privacy Policy . (codemint.net)
  • Moxidectin, a macrocyclic lactone, is an anthelmintic indicated for the treatment of onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older. (medscape.com)
  • These results strongly suggest that onchocerciasis patients produce antibodies that crossreact with the 46-kD human Ro/SS-A autoantigen (calreticulin) and raise the possibility that infectious organisms such as O. volvulus might play a triggering or exacerbating role in the human Ro/SS-A autoimmune response. (jci.org)
  • Onchocerciasis, commonly known as river blindness, is a neglected tropical disease (NTD) caused by the parasitic worm Onchocerca volvulus . (nri.org)
  • Although the Onchocerciasis Control Programme (OCP) in West Africa (1975-2002) has greatly improved the situation in its 11 participating countries, infection by Onchocerca volvulus (the causal agent of River Blindness ) still poses an important public health problem in many areas of Africa, Yemen, and Latin America. (imperial.ac.uk)
  • Onchocerciasis - or "river blindness" - is a parasitic disease caused by the filarial worm Onchocerca volvulus transmitted by repeated bites of infected blackflies (Simulium spp. (evanewyork.net)
  • Simplified life cycle of Onchocerciasis volvulus. (medscape.com)
  • Onchocerciasis is caused by the parasitic worm Onchocerca volvulus . (who.int)
  • An estimated 187 million people are at risk of O. volvulus infection, with 17-25 million people infected and 0.8 million showing some impairment of vision. (wikipedia.org)
  • With occult O. volvulus infection, serum levels of pro-inflammatory chemokines MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, MPIF-1/CCL23 and CXCL8/IL-8 enhanced and approached higher concentrations as determined in infection-free controls, whilst regulatory and Th2-type cytokines and chemokines MCP-4/CCL13, MIP-1δ/CCL15, TARC/CCL17 and IL-13 lessened. (nih.gov)
  • This study analysed the impact and the extent by which parental Onchocerca volvulus infection, intensity of transmission of O. volvulus infective 3rd-stage larvae (L3) and anthropometric factors may influence the acquisition, development and persistence of O. volvulus infection in offspring. (nih.gov)
  • Multiple logistic regression analysis showed that maternal O. volvulus infection and children's age are the predominant predictors for patent O. volvulus infection, while the intensity of transmission, measured by the annual transmission potential (ATP) of O. volvulus L3, was less decisive. (nih.gov)
  • Moreover there seems to be an association between epilepsy and the degree of infection with Onchocerca volvulus. (kit.nl)
  • Infection with nematodes of the genus ONCHOCERCA. (umassmed.edu)
  • Some experts recommend treating patients with 1 dose of ivermectin, then 6 weeks of doxycycline to kill Wolbachia, an endosymbiotic rickettsia-like bacterium that appears to be required for the survival of the O. volvulus adult worm and for embryogenesis. (cdc.gov)
  • In an effort to eliminate that disease, Merck &Co., Inc. has run mass drug administration campaigns since 1989 to treat entire communities with ivermectin, a drug that kills the Onchocerca worms and is used in this country to treat heartworm in pets, among other things. (broadinstitute.org)
  • The danger comes when people who are co-infected with both Onchocerca and Loa loa receive ivermectin treatment. (broadinstitute.org)
  • Desjardins and his colleagues hoped the sequence of Loa loa , along with those of Wuchereria bancrofti and Onchocerca volvulus , would shed some light on the host-parasite relationship, in addition to giving scientists valuable data to help explain the dangerous post-ivermectin reactions. (broadinstitute.org)
  • The worm (Onchocerca volvulus) is transmitted to humans as immature larvae through bites of infected black flies. (medindia.net)
  • O. volvulus parasites obtain nutrients from the human host by ingesting blood or by diffusion through their cuticle. (wikipedia.org)
  • 5) Were the species on the ark all "good" species (as originally created by God) or had some of them evolved into parasites like O. volvulus and black flies by the time of the flood? (blogspot.com)
  • O volvulus larvae mature into their sexually competent adult forms in these nodules. (medscape.com)
  • Moxidectin does not kill adult O volvulus . (medscape.com)
  • The WHO estimates that at least 12-15 years of annual treatment are required in high and moderate endemic areas to eliminate transmission, corresponding to the lifespan of the adult Onchocerca volvulus . (nri.org)
  • The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
  • The genome of Onchocerca volvulus, agent of river blindness. (cdc.gov)
  • Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents. (umassmed.edu)
  • In vitro production of enzymatically active O. volvulus prolyl 4-hydroxylase should facilitate identification of specific inhibitors of the parasite enzyme. (embl.de)
  • John O'Neill, an Irish surgeon, first described Onchocerca volvulus in 1874, when he found it to be the causative agent of 'craw-craw', a skin disease found in West Africa. (wikipedia.org)
  • This study has provided new data on the kinetics of Mf in the skin and eyes after IVM treatment of persons with light to moderate intensity Onchocerca volvulus infections that are common in Africa at this time. (wustl.edu)
  • In areas where Loa loa is endemic, particularly West Africa, people are often also infected with Onchocerca , the roundworm behind river blindness. (broadinstitute.org)
  • This further demonstrates the potential of C. elegans as a host for expression of candidate vaccine antigens from O. volvulus and affirms the role of C. elegans as a model for parasitic nematodes. (aber.ac.uk)
  • these changes may reflect a decreasing effector cell activation against Mf of O. volvulus, and in parallel, an enhancing inflammatory immune responsiveness. (nih.gov)
  • Subcutaneous nodule on hip caused by encysted Onchocerca volvulus. (medscape.com)
  • In the new study, 16,259 volunteers in 92 villages in Cameroon where both L. loa and O. volvulus are commonly found provided finger-prick blood samples. (medindia.net)
  • 3) Did Noah find a male and female O. volvulus to take on the ark or were human passengers serving as hosts? (blogspot.com)
  • 4) Did Noah bring male and female black flies that are needed to complete the life cycle of O. volvulus ? (blogspot.com)
  • So God's original creation didn't include Onchocerca volvulus , is that what you're saying, Berend? (blogspot.com)
  • O. volvulus has not directly caused a single death, but has cost 1.1 million disability adjusted life years, which measure the number of years of healthy life lost due to a specific disease and show the burden of a disease. (wikipedia.org)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Onchocerca volvulus is a filarial (arthropod-borne) nematode (roundworm) that causes onchocerciasis (river blindness), and is the second-leading cause of blindness due to infection worldwide after trachoma. (wikipedia.org)
  • Ongoing elimination efforts have altered the global distribution of Onchocerca volvulus, the agent of river blindness, and further population restructuring is expected as efforts continue. (nih.gov)
  • Onchocerca volvulus is a parasitic worm that causes river blindness, transmitted by blackflies and characterized by nodules under the skin, itching, and potential loss of vision. (hbot-india.com)
  • Human onchocerciasis (river blindness) caused by Onchocerca volvulus is endemic in 30 countries of sub-Saharan Africa and Yemen. (biomedcentral.com)
  • These flies transmit Onchocerca volvulus , the tiny parasitic worm responsible for river blindness. (nih.gov)
  • Onchocerciasis, commonly known as "river blindness", is caused by the parasitic worm Onchocerca volvulus . (who.int)
  • Onchocerciasis - or "river blindness" - is a parasitic disease caused by the filarial worm Onchocerca volvulus transmitted by repeated bites of infected blackflies ( Simulium spp. (who.int)
  • Multivalent vaccines are being developed against Onchocerca volvulus, the causative agent of river blindness, and against Stongyloides stercoralis. (jefferson.edu)
  • Onchocerciasis, or river blindness , is a filarial infection caused by the parasitic nematode, Onchocerca volvulus , carried by black flies of the genus Simulium . (encyclopedia.com)
  • Onchocerciasis, or river blindness, is caused by infection by the filarial worm Onchocerca volvulus which is transmitted by female black flies of the genus Simulium . (biomedcentral.com)
  • onchocerca volvulus causes river blindness and is transmitted by black flies of the genus simulium. (scoutgambia.org)
  • Of all the infectious, environmental and psychological factors associated with NS, the major culprit is Onchocerca Volvulus (Ov)-a parasitic worm transmitted to human by blackflies. (huji.ac.il)
  • O. volvulus is transmitted to humans by blackflies ( Simulium damnosum ), which breed in fast-flowing rivers and streams. (hopkinsguides.com)
  • Fain, A, Wéry, M & Tilkin, J 1981, ' Transmission d' Onchocerca volvulus par Simulium albivirgulatum dans le foyer d'onchocercose de la Cuvette Centrale, Zaïre ', Annales de la Société Belge de Médecine Tropicale , vol. 61, pp. 307-309. (itg.be)
  • Several types of parasitic roundworms have iPGM, including Brugia malayi and Onchocerca volvulus , which infect roughly 150 million people living mostly in tropical regions. (nih.gov)
  • The objective was to establish the impact of mass drug administration in combination with larviciding on the interruption of O. volvulus transmission. (sightsavers.org)
  • The principle was that, by controlling breeding sites of the flies for long enough, transmission could be interrupted while waiting for the adult parasites of Onchocerca volvulus to die (in infected individuals). (cehjournal.org)
  • Some experts recommend treating patients with 1 dose of ivermectin, then 6 weeks of doxycycline to kill Wolbachia, an endosymbiotic rickettsia-like bacterium that appears to be required for the survival of the O. volvulus adult worm and for embryogenesis. (cdc.gov)
  • John O'Neill, an Irish surgeon, first described Onchocerca volvulus in 1874, when he found it to be the causative agent of 'craw-craw', a skin disease found in West Africa. (wikipedia.org)
  • O. volvulus has been proposed as one of the causative agents of nodding syndrome, a condition that affects children aged 5 to 15 and is currently only observed in South Sudan, Tanzania, and northern Uganda. (wikipedia.org)
  • Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda-Clinical, EEG and Brain Imaging Features. (ox.ac.uk)
  • In the newly published research, the scientists describe sequencing the complete genomes of O. volvulus worms gathered from Ecuador, Uganda and West Africa. (nih.gov)
  • O. volvulus can also cause intense skin itching, leaving dead and discolored patches of skin in addition to the characteristic blindness. (scienceblogs.com)
  • To improve our understanding of the disease spectrum, we described the clinical, electroencephalographic (EEG) and magnetic resonance imaging (MRI) features of children with epilepsy and sero-positive for Onchocerca volvulus (possible OAEs other than nodding syndrome). (ox.ac.uk)
  • Light and electron microscopic immunohistology using antibodies against the recombinant protein showed labeling of lysosomes in the hypodermis and epithelia of the intestine and the reproductive organs of Onchocerca. (edu.au)
  • The phylogenetic analysis showed the high degree of identity between the identified O. ochengi and the O. volvulus galectin-1 (ß-galactoside-binding protein-1) consisting only in one exchange of alanine for serine. (biomedcentral.com)
  • To compare the magnitude of binding of both native and recombinant forms of tubulin, we developed an ELISA assay for estimating the amount of tubulin in soluble protein extracts of O. volvulus. (mak.ac.ug)
  • To enhance the immune response for our vaccine design, truncated (residues 10-153) Onchocerca volvulus activation-associated secreted protein-1 (Ov-ASP-1) has been utilized as an adjuvant at N terminal of both the MEVs. (biorxiv.org)
  • O. volvulus parasites obtain nutrients from the human host by ingesting blood or by diffusion through their cuticle. (wikipedia.org)
  • 17. Human macrophages and T-lymphocyte subsets infiltrating nodules of Onchocerca volvulus. (nih.gov)
  • Human isotype antibody responses to an Onchocerca volvulus glutathione S-transferase. (fq.edu.uy)
  • Studies on the biology of O. volvulus have been limited due to the lack of appropriate animal models [ 2 ]. (biomedcentral.com)
  • We describe an 11-year-old girl, a new immigrant from Ethiopia, who had a firm mass in her left thigh, caused by Onchocerca volvulus. (ima.org.il)
  • The effects of drugs on onchocerca volvulus: II. (who.int)
  • O. volvulus has not directly caused a single death, but has cost 1.1 million disability adjusted life years, which measure the number of years of healthy life lost due to a specific disease and show the burden of a disease. (wikipedia.org)
  • Robust disease surveillance is a cornerstone of global health efforts that range from detecting emerging pathogens and epidemics to the control or elimination of vaccine-preventable diseases, HIV, malaria, and neglected tropical diseases (NTDs) ( http://www.who.int/neglected_diseases/9789241564540/en/ ) ( 2 - 4 ). (cdc.gov)