Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. It includes the OLFACTORY NERVE; OLFACTORY BULB; OLFACTORY TRACT; OLFACTORY TUBERCLE; ANTERIOR PERFORATED SUBSTANCE; and OLFACTORY CORTEX.
Ovoid body resting on the CRIBRIFORM PLATE of the ethmoid bone where the OLFACTORY NERVE terminates. The olfactory bulb contains several types of nerve cells including the mitral cells, on whose DENDRITES the olfactory nerve synapses, forming the olfactory glomeruli. The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here.
Neurons in the OLFACTORY EPITHELIUM with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. These neurons send their DENDRITES to the surface of the epithelium with the odorant receptors residing in the apical non-motile cilia. Their unmyelinated AXONS synapse in the OLFACTORY BULB of the BRAIN.
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.
The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)
An infraorder of CRUSTACEA, in the order DECAPODA comprising the hermit crabs and characterized by a small fifth pair of legs.
A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.
Paired sense organs connected to the anterior segments of ARTHROPODS that help them navigate through the environment.
Loss of or impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATORY TRACT INFECTIONS; CRANIOCEREBRAL TRAUMA; SMOKING; and other conditions.
The process by which the nature and meaning of olfactory stimuli, such as odors, are recognized and interpreted by the brain.
That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.
Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.
The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.
Proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the neurons. The large number of different odorant receptors appears to arise from several gene families or subfamilies rather than from DNA rearrangement.
Prominent lobed neuropils found in ANNELIDA and all ARTHROPODS except crustaceans. They are thought to be involved in olfactory learning and memory.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A ubiquitous, cytoplasmic protein found in mature OLFACTORY RECEPTOR NEURONS of all VERTEBRATES. It is a modulator of the olfactory SIGNAL TRANSDUCTION PATHWAY.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Traumatic injuries to the OLFACTORY NERVE. It may result in various olfactory dysfunction including a complete loss of smell.

A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene. (1/1308)

The wiring patterns among various types of neurons via specific synaptic connections are the basis of functional logic employed by the brain for information processing. This study introduces a powerful method of analyzing the neuronal connectivity patterns by delivering a tracer selectively to specific types of neurons while simultaneously transsynaptically labeling their target neurons. We developed a novel genetic approach introducing cDNA for a plant lectin, wheat germ agglutinin (WGA), as a transgene under the control of specific promoter elements. Using this method, we demonstrate three examples of visualization of specific transsynaptic neural pathways: the mouse cerebellar efferent pathways, the mouse olfactory pathways, and the Drosophila visual pathways. This strategy should greatly facilitate studies on the anatomical and functional organization of the developing and mature nervous system.  (+info)

Sodefrin: a novel sex pheromone in a newt. (2/1308)

The abdominal gland in the male red-bellied newt, Cynops pyrrhogaster, is the source of a female-attracting pheromone. An attempt was made to isolate and characterize the female-attracting pheromone in the abdominal glands of male newts. The active substance, named sodefrin (from the Japanese 'sodefuri' which means 'soliciting') has been isolated and shown to be a novel decapeptide with the sequence, Ser-Ile-Pro-Ser-Lys-Asp-Ala-Leu-Leu-Lys. Its minimum effective concentration in water is 0.1-1.0 pmol 1-1. Synthetic sodefrin shows a female-attracting activity similar to that of the native peptide, and acts through the olfactory organ of female newts. Electrophysiological studies reveal that sodefrin evokes a marked electroolfactogram response in the vomeronasal epithelium in sexually mature females and in ovariectomized females treated with prolactin and oestrogen. The pheromonal activity of sodefrin appears to be species-specific since it does not attract females of a congeneric species, the sword-tailed newt C. ensicauda. However, C. ensicauda has a variant of sodefrin differing from that in C. pyrrhogaster by substitutions of Leu for Pro at position 3 and Gln for Leu at position 8. The C. ensicauda variant sodefrin does not attract C. pyrrhogaster females. Genes encoding the sodefrin precursor protein have been cloned in both C. pyrrhogaster and C. ensicauda. Immunostaining of the abdominal gland using the antiserum against sodefrin shows that sodefrin occurs in the epithelial cells, predominantly within the secretory granules. Sodefrin content, detected by immunoassay, in C. pyrrhogaster males decreases after castration and hypophysectomy and increases markedly in the castrated and hypophysectomized newts after treatment with androgen and prolactin. This combination of hormones also enhances sodefrin mRNA content in the abdominal gland as assessed by northern blot analysis using sodefrin cDNA.  (+info)

A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. (3/1308)

Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. We have developed a novel search algorithm, used it to search the Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. Different members of the family initiate expression at different times during antennal development. Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities.  (+info)

The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor. (4/1308)

Little is known about how the odor specificities of olfactory neurons are generated, a process essential to olfactory coding. We have found that neuronal identity relies on the abnormal chemosensory jump 6 (acj6) gene, originally identified by a defect in olfactory behavior. Physiological analysis of individual olfactory neurons shows that in acj6 mutants, a subset of neurons acquires a different odorant response profile. Certain other neurons do not respond to any tested odors in acj6. Molecular analysis of acj6 shows that it encodes a POU-domain transcription factor expressed in olfactory neurons. Our data suggest that the odor response spectrum of an olfactory neuron, and perhaps the choice of receptor genes, is determined through a process requiring the action of Acj6.  (+info)

Crossmodal associative memory representations in rodent orbitofrontal cortex. (5/1308)

Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampled particular odors. Furthermore, a substantial fraction of the cells exhibited odor-specific firing patterns prior to odor presentation, when the animal arrived at a location associated with that odor. These findings suggest that neurons in the OF encode cross-modal associations between odors and locations within long-term memory.  (+info)

Blind smell: brain activation induced by an undetected air-borne chemical. (6/1308)

EEG and behavioural evidence suggests that air-borne chemicals can affect the nervous system without being consciously detected. EEG and behaviour, however, do not specify which brain structures are involved in chemical sensing that occurs below a threshold of conscious detection. Here we used functional MRI to localize brain activation induced by high and low concentrations of the air-borne compound oestra-1,3,5(10),16-tetraen-3yl acetate. Following presentations of both concentrations, eight of eight subjects reported verbally that they could not detect any odour (P = 0.004). Forced choice detection performed during the presentations revealed above-chance detection of the high concentration, but no better than chance detection of the low concentration compound. Both concentrations induced significant brain activation, primarily in the anterior medial thalamus and inferior frontal gyrus. Activation in the inferior frontal gyrus during the high concentration condition was significantly greater in the right than in the left hemisphere (P = 0.03). A trend towards greater thalamic activation was observed for the high concentration than the low concentration compound (P = 0.08). These findings localize human brain activation that was induced by an undetectable air-borne chemical (the low concentration compound).  (+info)

Adenovirus-mediated expression of an olfactory cyclic nucleotide-gated channel regulates the endogenous Ca2+-inhibitable adenylyl cyclase in C6-2B glioma cells. (7/1308)

Previous studies have established that Ca2+-sensitive adenylyl cyclases, whether endogenously or heterologously expressed, are preferentially regulated by capacitative Ca2+ entry, compared with other means of elevating cytosolic Ca2+ (Chiono, M., Mahey, R., Tate, G., and Cooper, D. M. F. (1995) J. Biol. Chem. 270, 1149-1155; Fagan, K. A., Mahey, R., and Cooper, D. M. F. (1996) J. Biol. Chem. 271, 12438-12444; Fagan, K. A., Mons, N., and Cooper, D. M. F. (1998) J. Biol. Chem. 273, 9297-9305). These findings led to the suggestion that adenylyl cyclases and capacitative Ca2+ entry channels were localized in the same functional domain of the plasma membrane. In the present study, we have asked whether a heterologously expressed Ca2+-permeable channel could regulate the Ca2+-inhibitable adenylyl cyclase of C6-2B glioma cells. The cDNA coding for the rat olfactory cyclic nucleotide-gated channel was inserted into an adenovirus construct to achieve high levels of expression. Electrophysiological measurements confirmed the preservation of the properties of the expressed olfactory channel. Stimulation of the channel with cGMP analogs yielded a robust elevation in cytosolic Ca2+, which was associated with an inhibition of cAMP accumulation, comparable with that elicited by capacitative Ca2+ entry. These findings not only extend the means whereby Ca2+-sensitive adenylyl cyclases may be regulated, they also suggest that in tissues where they co-exist, cyclic nucleotide-gated channels and Ca2+-sensitive adenylyl cyclases may reciprocally modulate each other's activity.  (+info)

From embryo to adult: persistent neurogenesis and apoptotic cell death shape the lobster deutocerebrum. (8/1308)

Neuronal plasticity and synaptic remodeling play important roles during the development of the invertebrate nervous system. In addition, structural neuroplasticity as a result of long-term environmental changes, behavioral modifications, age, and experience have been demonstrated in the brains of sexually mature insects. In adult vertebrates, persistent neurogenesis is found in the granule cell layer of the mammalian hippocampus and the subventricular zone, as well as in the telencephalon of songbirds, indicating that persistent neurogenesis, which is presumably related to plasticity and learning, may be an integral part of the normal biology of the mature brain. In decapod crustaceans, persistent neurogenesis among olfactory projection neurons is a common principle that shapes the adult brain, indicating a remarkable degree of life-long structural plasticity. The present study closes a gap in our knowledge of this phenomenon by describing the continuous cell proliferation and gradual displacement of proliferation domains in the central olfactory pathway of the American lobster Homarus americanus from early embryonic through larval and juvenile stages into adult life. Neurogenesis in the deutocerebrum was examined by the in vivo incorporation of bromodeoxyuridine, and development and structural maturation of the deutocerebral neuropils were studied using immunohistochemistry against Drosophila synapsin. The role of apoptotic cell death in shaping the developing deutocerebrum was studied using the terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling method, combined with immunolabeling using an antiphospho histone H3 mitosis marker. Our results indicate that, in juvenile and adult lobsters, birth and death of olfactory interneurons occur in parallel, suggesting a turnover of these cells. When the persistent neurogenesis and concurrent death of interneurons in the central olfactory pathway of the crustacean brain are taken into account with the life-long turnover of olfactory receptor cells in crustacean antennules, a new, highly dynamic picture of olfaction in crustaceans emerges.  (+info)

The olfactory pathways refer to the neural connections and structures involved in the sense of smell. The process begins with odor molecules that are inhaled through the nostrils, where they bind to specialized receptor cells located in the upper part of the nasal cavity, known as the olfactory epithelium.

These receptor cells then transmit signals via the olfactory nerve (cranial nerve I) to the olfactory bulb, a structure at the base of the brain. Within the olfactory bulb, the signals are processed and relayed through several additional structures, including the olfactory tract, lateral olfactory striae, and the primary olfactory cortex (located within the piriform cortex).

From there, information about odors is further integrated with other sensory systems and cognitive functions in higher-order brain regions, such as the limbic system, thalamus, and hippocampus. This complex network of olfactory pathways allows us to perceive and recognize various scents and plays a role in emotional responses, memory formation, and feeding behaviors.

The olfactory bulb is the primary center for the sense of smell in the brain. It's a structure located in the frontal part of the brain, specifically in the anterior cranial fossa, and is connected to the nasal cavity through tiny holes called the cribriform plates. The olfactory bulb receives signals from olfactory receptors in the nose that detect different smells, processes this information, and then sends it to other areas of the brain for further interpretation and perception of smell.

Olfactory receptor neurons (ORNs) are specialized sensory nerve cells located in the olfactory epithelium, a patch of tissue inside the nasal cavity. These neurons are responsible for detecting and transmitting information about odors to the brain. Each ORN expresses only one type of olfactory receptor protein, which is specific to certain types of odor molecules. When an odor molecule binds to its corresponding receptor, it triggers a signal transduction pathway that generates an electrical impulse in the neuron. This impulse is then transmitted to the brain via the olfactory nerve, where it is processed and interpreted as a specific smell. ORNs are continuously replaced throughout an individual's lifetime due to their exposure to environmental toxins and other damaging agents.

In medical terms, the sense of smell is referred to as olfaction. It is the ability to detect and identify different types of chemicals in the air through the use of the olfactory system. The olfactory system includes the nose, nasal passages, and the olfactory bulbs located in the brain.

When a person inhales air containing volatile substances, these substances bind to specialized receptor cells in the nasal passage called olfactory receptors. These receptors then transmit signals to the olfactory bulbs, which process the information and send it to the brain's limbic system, including the hippocampus and amygdala, as well as to the cortex. The brain interprets these signals and identifies the various scents or smells.

Impairment of the sense of smell can occur due to various reasons such as upper respiratory infections, sinusitis, nasal polyps, head trauma, or neurodegenerative disorders like Parkinson's disease and Alzheimer's disease. Loss of smell can significantly impact a person's quality of life, including their ability to taste food, detect dangers such as smoke or gas leaks, and experience emotions associated with certain smells.

In the context of medicine, "odors" refer to smells or scents that are produced by certain medical conditions, substances, or bodily functions. These odors can sometimes provide clues about underlying health issues. For example, sweet-smelling urine could indicate diabetes, while foul-smelling breath might suggest a dental problem or gastrointestinal issue. However, it's important to note that while odors can sometimes be indicative of certain medical conditions, they are not always reliable diagnostic tools and should be considered in conjunction with other symptoms and medical tests.

Anomura is an order of crustaceans that includes hermit crabs, king crabs, and related species. These decapod crustaceans are characterized by the modification or absence of the last pair of pleopods (swimming legs) in the adult stage. The name "Anomura" comes from the Greek words "anomos," meaning unusual, and "oura," meaning tail.

Hermit crabs are known for their unique behavior of using empty gastropod shells as portable shelters, while king crabs have a distinctive broad and flattened appearance with a thick, spiny carapace. Anomurans can be found in various marine habitats worldwide, from shallow coastal waters to the deep sea. Some species are also adapted to freshwater or terrestrial environments.

Neuropil refers to the complex network of interwoven nerve cell processes (dendrites, axons, and their synaptic connections) in the central nervous system that forms the basis for information processing and transmission. It is the part of the brain or spinal cord where the neuronal cell bodies are not present, and it mainly consists of unmyelinated axons, dendrites, and synapses. Neuropil plays a crucial role in neural communication and is often the site of various neurochemical interactions.

Arthropod antennae are the primary sensory organs found in arthropods, which include insects, crustaceans, arachnids, and myriapods. These paired appendages are usually located on the head or nearest segment to the head and are responsible for detecting various stimuli from the environment such as touch, taste, smell, temperature, humidity, vibration, and air motion.

The structure of arthropod antennae varies among different groups but generally consists of one or more segments called flagellum or funicle that may be further divided into subsegments called annuli. The number and arrangement of these segments are often used to classify and identify specific taxa.

Insect antennae, for example, typically have a distinct shape and can be thread-like, feathery, or clubbed depending on the species. They contain various sensory receptors such as olfactory neurons that detect odor molecules, mechanoreceptors that respond to touch or movement, and thermoreceptors that sense temperature changes.

Overall, arthropod antennae play a crucial role in enabling these organisms to navigate their environment, find food, avoid predators, and communicate with conspecifics.

Olfaction disorders, also known as smell disorders, refer to conditions that affect the ability to detect or interpret odors. These disorders can be categorized into two main types:

1. Anosmia: This is a complete loss of the sense of smell. It can be caused by various factors such as nasal polyps, sinus infections, head injuries, and degenerative diseases like Alzheimer's and Parkinson's.
2. Hyposmia: This is a reduced ability to detect odors. Like anosmia, it can also be caused by similar factors including aging and exposure to certain chemicals.

Other olfaction disorders include parosmia, which is a distortion of smell where individuals may perceive a smell as being different from its original scent, and phantosmia, which is the perception of a smell that isn't actually present.

Olfactory perception refers to the ability to perceive and recognize odors or smells, which is mediated by olfactory receptor neurons located in the nasal cavity. These neurons detect and transmit information about chemical compounds present in the inhaled air to the brain, specifically to the primary olfactory cortex, where the perception of smell is processed and integrated with other sensory inputs. Olfactory perception plays a crucial role in various aspects of human behavior, including food selection, safety, and emotional responses.

The olfactory mucosa is a specialized mucous membrane that is located in the upper part of the nasal cavity, near the septum and the superior turbinate. It contains the olfactory receptor neurons, which are responsible for the sense of smell. These neurons have hair-like projections called cilia that are covered in a mucus layer, which helps to trap and identify odor molecules present in the air we breathe. The olfactory mucosa also contains supporting cells, blood vessels, and nerve fibers that help to maintain the health and function of the olfactory receptor neurons. Damage to the olfactory mucosa can result in a loss of smell or anosmia.

Cadmium radioisotopes are unstable forms of the heavy metal cadmium that emit radiation as they decay into more stable elements. These isotopes can be created through various nuclear reactions, such as bombarding a cadmium atom with a high-energy particle. Some common cadmium radioisotopes include cadmium-109, cadmium-113, and cadmium-115.

These radioisotopes have a wide range of applications in medicine, particularly in diagnostic imaging and radiation therapy. For example, cadmium-109 is used as a gamma ray source for medical imaging, while cadmium-115 has been studied as a potential therapeutic agent for cancer treatment.

However, exposure to cadmium radioisotopes can also be hazardous to human health, as they can cause damage to tissues and organs through ionizing radiation. Therefore, handling and disposal of these materials must be done with care and in accordance with established safety protocols.

The olfactory nerve, also known as the first cranial nerve (I), is a specialized sensory nerve that is responsible for the sense of smell. It consists of thin, delicate fibers called olfactory neurons that are located in the upper part of the nasal cavity. These neurons have hair-like structures called cilia that detect and transmit information about odors to the brain.

The olfactory nerve has two main parts: the peripheral process and the central process. The peripheral process extends from the olfactory neuron to the nasal cavity, where it picks up odor molecules. These molecules bind to receptors on the cilia, which triggers an electrical signal that travels along the nerve fiber to the brain.

The central process of the olfactory nerve extends from the olfactory bulb, a structure at the base of the brain, to several areas in the brain involved in smell and memory, including the amygdala, hippocampus, and thalamus. Damage to the olfactory nerve can result in a loss of smell (anosmia) or distorted smells (parosmia).

Odorant receptors are a type of G protein-coupled receptor (GPCR) that are primarily found in the cilia of olfactory sensory neurons in the nose. These receptors are responsible for detecting and transmitting information about odorants, or volatile molecules that we perceive as smells.

Each odorant receptor can bind to a specific set of odorant molecules, and when an odorant binds to its corresponding receptor, it triggers a signaling cascade that ultimately leads to the generation of an electrical signal in the olfactory sensory neuron. This signal is then transmitted to the brain, where it is processed and interpreted as a particular smell.

There are thought to be around 400 different types of odorant receptors in humans, each with its own unique binding profile. The combinatorial coding of these receptors allows for the detection and discrimination of a vast array of different smells, from sweet to sour, floral to fruity, and everything in between.

Overall, the ability to detect and respond to odorants is critical for many important functions, including the identification of food, mates, and potential dangers in the environment.

"Mushroom bodies" is a term that is primarily used in the field of insect neuroanatomy, rather than human or mammalian medicine. They are a pair of prominent structures in the insect brain, located in the olfactory processing center and involved in sensory integration, learning, and memory.

These structures have a distinctive morphology, resembling a mushroom with a large cap-like structure (the calyx) sitting atop a stalk (the peduncle). The calyx receives input from various sensory neurons, while the peduncle and its downstream processes are involved in information processing and output.

While not directly relevant to human medicine, understanding the organization and function of insect nervous systems can provide valuable insights into the evolution of neural circuits and behaviors across species.

Sensory receptor cells are specialized structures that convert physical stimuli from our environment into electrical signals, which are then transmitted to the brain for interpretation. These receptors can be found in various tissues throughout the body and are responsible for detecting sensations such as touch, pressure, temperature, taste, and smell. They can be classified into two main types: exteroceptors, which respond to stimuli from the external environment, and interoceptors, which react to internal conditions within the body. Examples of sensory receptor cells include hair cells in the inner ear, photoreceptors in the eye, and taste buds on the tongue.

Neurons, also known as nerve cells or neurocytes, are specialized cells that constitute the basic unit of the nervous system. They are responsible for receiving, processing, and transmitting information and signals within the body. Neurons have three main parts: the dendrites, the cell body (soma), and the axon. The dendrites receive signals from other neurons or sensory receptors, while the axon transmits these signals to other neurons, muscles, or glands. The junction between two neurons is called a synapse, where neurotransmitters are released to transmit the signal across the gap (synaptic cleft) to the next neuron. Neurons vary in size, shape, and structure depending on their function and location within the nervous system.

The olfactory marker protein (OMP) is a specific type of protein that is primarily found in the olfactory sensory neurons of the nose. These neurons are responsible for detecting and transmitting information about odors to the brain. The OMP plays a crucial role in the function of these neurons, as it helps to maintain their structure and stability. It also contributes to the process of odor detection by helping to speed up the transmission of signals from the olfactory receptors to the brain.

The presence of OMP is often used as a marker for mature olfactory sensory neurons, as it is not typically found in other types of cells. Additionally, changes in the expression levels of OMP have been associated with various neurological conditions, such as Alzheimer's disease and Parkinson's disease, making it a potential target for diagnostic and therapeutic purposes.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

Olfactory nerve injuries refer to damages or trauma inflicted on the olfactory nerve, which is the first cranial nerve (CN I) responsible for the sense of smell. The olfactory nerve has sensory receptors in the nasal cavity that detect and transmit smell signals to the brain.

Olfactory nerve injuries can occur due to various reasons, such as head trauma, viral infections, exposure to toxic chemicals, or neurodegenerative diseases like Parkinson's and Alzheimer's. The injury may result in a reduced or complete loss of the sense of smell (anosmia) or distorted smells (parosmia).

The diagnosis of olfactory nerve injuries typically involves a thorough clinical evaluation, including a detailed medical history, physical examination, and specific tests like those assessing the ability to identify and discriminate between various odors. Treatment options depend on the underlying cause and may include medications, surgery, or rehabilitation strategies aimed at improving sensory function.

... olfactory bulb; ObP, olfactory bulb peduncle; OC, olfactory cortex; OE, olfactory epithelium; OP, occipital pole; P, piriform ... there is limited work on the olfactory pathways. A functional MRI (fMRI) study mapping the olfactory system in both awake and ... the olfactory system is composed of sensory neurons that transmit information from olfactory epithelium to the olfactory bulb, ... As part of our project we provided mean volume and FA parameters for each olfactory pathway. FA is a diffusivity parameter that ...
HHV-6 encephalopathy associated with structural changes in the olfactory pathway. Latvian researchers studied autopsy material ... Ultrastructural changes in the olfactory pathways of HHV-6+ patients. Source: PLOS ONE ... The prevalence of HHV-6 in diseased tissues of the olfactory tract/bulb was 60%- higher than in the tissues of both age-matched ... The team, led by Modra Murovska from the Riga Stradins University, determined that HHV-6 viral loads in olfactory bulb tissue ...
The olfactory system represents one of the oldest sensory modalities in the phylogenetic history of mammals. (See the image ... Olfactory Tract and Central Pathways. Mitral cell axons project to the olfactory cortex via the olfactory tract. Medial fibers ... Olfactory Bulb. The olfactory bulb lies inferior to the basal frontal lobe. The olfactory bulb is a highly organized structure ... Olfactory Epithelium. The olfactory epithelium consists of 3 cell types: basal, supporting, and olfactory receptor cells. Basal ...
Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees. In: Journal of ... Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees. / Wright, Geraldine A ... Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees. Journal of ... Wright, GA, Mustard, JA, Kottcamp, SM & Smith, B 2007, Olfactory memory formation and the influence of reward pathway during ...
... Gian Luca Breschi;Carlo Ciliberto; ... In this paper we present a machine learning approach to derive the input-output function of the olfactory-limbic pathway in the ... In this paper we present a machine learning approach to derive the input-output function of the olfactory-limbic pathway in the ... We first experimentally characterized the neuronal pathway by delivering different sets of electrical stimuli from the lateral ...
Anosmia in subjects with dementia is associated with Lewy pathology in the olfactory pathways ... Anosmia in subjects with dementia is associated with Lewy pathology in the olfactory pathways ...
Olfactory Bulb / physiology* * Olfactory Mucosa / innervation* * Olfactory Pathways / physiology * Pheromones / physiology* * ... These processes are mediated by the main olfactory system but not the vomeronasal accessory-olfactory system. ... but elimination of main olfactory system function by ZnSO4 treatment of the olfactory mucosa did abolish such preferences. Thus ... Individual recognition of female hamsters by males: role of chemical cues and of the olfactory and vomeronasal systems Physiol ...
Pyramidal neurons in the piriform cortex from olfactory-discrimination-trained rats have reduced postburst ... Olfactory Pathways / physiology * Rats * Rats, Sprague-Dawley * Small-Conductance Calcium-Activated Potassium Channels / drug ... Pyramidal neurons in the piriform cortex from olfactory-discrimination-trained rats have reduced postburst ... may act to counterbalance learning-induced hyperexcitability and preserve the piriform cortex ability to subserve olfactory ...
... and is brought into view by throwing back the olfactory tract. It is part of the olfactory pathway. This article incorporates ... "Elemental imbalances in the olfactory pathway in Alzheimers disease". J. Neurol. Sci. 130 (2): 139-45. doi:10.1016/0022-510X( ... The olfactory trigone is a small triangular area in front of the anterior perforated substance. Its apex, directed forward, ... occupies the posterior part of the olfactory sulcus, ... Olfactory system, All stub articles, Neuroanatomy stubs). ...
Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees Geraldine A. Wright, ... In typical olfactory classical conditioning in honey bees, both pathways are stimulated with sucrose (US) to produce a CS-US ... The purpose of the present study is to investigate the extent to which the reward pathway experienced during olfactory learning ... Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees. J Exp Biol 15 November ...
Brain regions important in recognizing smells (olfactory pathways). Types of Lewy body dementia. Lewy body dementia includes ...
2006) Dual olfactory pathway in the honeybee, Apis mellifera. J Comp Neurol 499:933-952, doi:10.1002/cne.21158, pmid:17072827. ... A, Dual olfactory pathway of the honey bee brain (adapted from Carcaud et al., 2012). Odorant molecules are detected by ORNs on ... 2012) Dynamics of sensory processing in the dual olfactory pathway of the honeybee. Apidologie 43:269-291, doi:10.1007/s13592- ... 2013) Parallel processing via a dual olfactory pathway in the honeybee. J Neurosci 33:2443-2456, doi:10.1523/JNEUROSCI.4268- ...
Post-COVID-19 persistent olfactory, gustatory, and trigeminal chemosensory disorders: Definitions, mechanisms, and potential ... Figure 1 Olfactory perception and its pathways. There are two routes for odor perception: The orthonasal and retronasal routes ... The olfactory information is carried out from the olfactory neuroepithelium, nerves, bulb, and brain. The olfactory mucosa is ... Figure 2 Structure of the olfactory mucosa and topographical mapping of the olfactory sensory neurons and their connections. A ...
Brain regions important in recognizing smells (olfactory pathways). Who is affected by LBD? Although less known than its " ...
The olfactory pathway does not involve a thalamic relay prior to its cortical projections. Relays from the olfactory tubercle ... Olfactory dysfunction. Disturbances in olfaction can result from pathologic processes at any level along the olfactory pathway ... Treatment of Olfactory and Gustatory Dysfunction. Treatment of olfactory dysfunction. Any treatment of olfactory disorders must ... the anterior olfactory nucleus, connecting the 2 olfactory bulbs through the anterior commissure, (2) the olfactory tubercle, ( ...
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes GENES AND NUTRITION. 14, ...
In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in ... and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and rprml is found in the telencephalon. At the ... In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) ... Whitlock, K. E., and Westerfield, M. (1998). A transient population of neurons pioneers the olfactory pathway in the zebrafish ...
... revealing that context-dependent engagement of distinct intracellular signaling pathways within a single sensory neuron type is ... sufficient to switch olfactory preference behavior to an individual odorant from attraction to aversion. ... Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron. 1995;14:803-12. pmid:7718242 * View ... A) Cartoon of the olfactory signal transduction pathway in AWC. Adapted from [61]. (B) Average residence histograms and ...
The present study addresses this research gap by assessing differences in olfactory abilities between 39 depressed mothers, who ... The assessments include two olfactory testing sessions conducted 4-weeks apart, each comprising a standard odour detection ... threshold test (i.e., Snap & Sniff Olfactory Test System), and intensity and valence ratings for 3 ... their distinct involvements of olfactory pathways.. Research on olfactory hedonic perception has particular importance for ...
"Representations of olfactory scenes in feedforward and feedback pathways to the olfactory bulb. " ... "In Silico Modeling of PICK1 Protein Dynamics and Interactions: Pathway to Peptide-based Therapies for Substance Use Disorders" ...
Lie, J., et al. (2021). What's that smell? A pictorial review of the olfactory pathways and imaging assessment of the ... Phantosmia is also called a phantom smell or an olfactory hallucination. Causes include problems with the nose, such as ... Idot;şlek, A., et al. (2021). Phantosmia with COVID-19 related olfactory dysfunction: Report of nine case.. https://www. ... Wehling, E., et al. (2021). Olfactory hallucinations in a population-based sample.. https://www.sciencedirect.com/science/ ...
Mate discrimination among subspecies through a conserved olfactory pathway. Science Advances 6 (25), eaba5279 (2020) ... Das Chakraborty, S.; Chang, H.; Hansson, B. S.; Sachse, S.: Higher-order olfactory neurons in the lateral horn support odor ... Campetella, F.; Ignell, R.; Beutel, R.; Hansson, B. S.; Sachse, S.: Comparative dissection of the peripheral olfactory system ... Das Chakraborty, S.; Sachse, S.: Olfactory processing in the lateral horn of Drosophila. Cell and Tissue Research 383, pp. 113 ...
... that is without deviation via olfactory receptors and complex biochemical signalling pathways as found in olfactory cells. ... The "Lily of the Valley phenomenon" is a laboratory artefact: sperm do not have an olfactory signalling pathway. ... was born as a result of this discovery that sperm act as swimming olfactory cells which follow a "scent trail" laid by the egg ... have now discovered that sperm do not function like olfactory cells - a finding that casts doubt on the assumption that scents ...
2013) Parallel processing via a dual olfactory pathway in the honeybee The Journal of Neuroscience 33:2443-2456. ... 2014) Parallel pathways convey olfactory information with opposite polarities in Drosophila Proceedings of the National Academy ... 2004) Integration of chemosensory pathways in the Drosophila second-order olfactory centers Current Biology 14:449-457. ... We characterized an olfactory-processing pathway, comprised of inhibitory projection neurons (iPNs) that target the LH ...
We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) ... We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) ... However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our ... However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our ...
Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway. Proceedings of the ... Lind RW, Swanson LW, Ganten D. Angiotensin II immunoreactive pathways in the central nervous system of the rat: evidence for a ... Autoradiographic evidence for pathways from the medial preoptic area to the midbrain involved in the drinking response to ... Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron. 46: 647-60. ...
Thus both odors activate the same olfactory glomerulus, just through different neuronal pathways. Together, the scents evoke an ... Proof That the Olfactory System of Fruit Flies is Based on Self-Regulation of Odorant Receptors ... Glomeruli are spherical functional units in the antennal lobe, the olfactory center in the fly brain. "We were able to show in ... Both odors together intensify the activation of DA1," explains Silke Sachse, head of the "Olfactory Coding" research group. The ...
Olfactory Localization: the what and where pathways in Human Olfaction. Localization of biologically relevant stimuli in the ...
"By using the special organization of the olfactory pathways, memories can be manipulated in a local manner on one side of the ...
However, whether olfactory exposure to essential oils affects night-time... , Find, read and cite all the research you need on ... Thus, olfactory enrichment may provide an effective and low-effort pathway to improved brain health. ... tion of human olfactory cortex. Nature 360:339-340.. Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., Ives, J.R., Dollins, A.B., ... To test olfactory function, subjects were exposed to several odors and. water and asked whether they could detect each. Those ...

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