Oculomotor Nerve Diseases: Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)Oculomotor Nerve: The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain.Oculomotor Nerve Injuries: Traumatic injuries to the OCULOMOTOR NERVE. This may result in various eye movement dysfunction.Ophthalmoplegia: Paralysis of one or more of the ocular muscles due to disorders of the eye muscles, neuromuscular junction, supporting soft tissue, tendons, or innervation to the muscles.Mydriasis: Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.Trochlear Nerve: The 4th cranial nerve. The trochlear nerve carries the motor innervation of the superior oblique muscles of the eye.Abducens Nerve: The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.Anisocoria: Unequal pupil size, which may represent a benign physiologic variant or a manifestation of disease. Pathologic anisocoria reflects an abnormality in the musculature of the iris (IRIS DISEASES) or in the parasympathetic or sympathetic pathways that innervate the pupil. Physiologic anisocoria refers to an asymmetry of pupil diameter, usually less than 2mm, that is not associated with disease.InkParasympathetic Fibers, Postganglionic: Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters.Blepharoptosis: Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.Oculomotor Muscles: The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris.Cranial Nerve Neoplasms: Benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.Circle of Willis: A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.Nerve Compression Syndromes: Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.Abducens Nerve Diseases: Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.Cavernous Sinus: An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.Surgical Instruments: Hand-held tools or implements used by health professionals for the performance of surgical tasks.Reflex, Pupillary: Constriction of the pupil in response to light stimulation of the retina. It refers also to any reflex involving the iris, with resultant alteration of the diameter of the pupil. (Cline et al., Dictionary of Visual Science, 4th ed)Cranial Nerve Diseases: Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.Exotropia: A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Neurosurgical Procedures: Surgery performed on the nervous system or its parts.Hematoma, Subdural, Chronic: Accumulation of blood in the SUBDURAL SPACE with delayed onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.Pupil: The aperture in the iris through which light passes.Petrous Bone: The dense rock-like part of temporal bone that contains the INNER EAR. Petrous bone is located at the base of the skull. Sometimes it is combined with the MASTOID PROCESS and called petromastoid part of temporal bone.Peripheral Nerves: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.Optic Nerve: The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Ganglia, Parasympathetic: Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Dissection: The separation and isolation of tissues for surgical purposes, or for the analysis or study of their structures.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Decompression, Surgical: A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Nerve Endings: Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.Sural Nerve: A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.Median Nerve: A major nerve of the upper extremity. In humans, the fibers of the median nerve originate in the lower cervical and upper thoracic spinal cord (usually C6 to T1), travel via the brachial plexus, and supply sensory and motor innervation to parts of the forearm and hand.Facial Nerve: The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.Nerve Crush: Treatment of muscles and nerves under pressure as a result of crush injuries.Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.Tibial Nerve: The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.Ulnar Nerve: A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Femoral Nerve: A nerve originating in the lumbar spinal cord (usually L2 to L4) and traveling through the lumbar plexus to provide motor innervation to extensors of the thigh and sensory innervation to parts of the thigh, lower leg, and foot, and to the hip and knee joints.

*  Nasopalatine nerve | Radiology Reference Article | Radiopaedia.org

... also known as the long sphenopalatine nerve) is a branch of the maxillary division of the trigeminal nerve and contributes to ... Gross anatomy The nasopalatine nerve divides off the maxillary d... ... oculomotor nerve (CN III). * trochlear nerve (CN IV). * trigeminal nerve (mnemonic) (CN V) *ophthalmic division *tentorial ... The nasopalatine nerve (also known as the long sphenopalatine nerve) is a branch of the maxillary division of the trigeminal ...

*  Superior orbital fissure nerves (mnemonic) | Radiology Reference Article | Radiopaedia.org

Mnemonics for the nerves passing though the superior orbital fissure include: Lazy French Tarts Sit Nakedly In Anticipation ... oculomotor nerve (CN III). * trochlear nerve (CN IV). * trigeminal nerve (mnemonic) (CN V) *ophthalmic division *tentorial ... The order of the nerves passing through the superior orbital fissure from superior to inferior:. * L: lacrimal nerve (branch of ... Superior orbital fissure nerves (mnemonic). Mr Andrew Murphy ◉ and A.Prof Frank Gaillard ◉ ◈ et al. ...

*  A Rare Presentation of Isolated Oculomotor Nerve Palsy due to Multiple Sclerosis in a Child

Isolated oculomotor nerve palsy is found rarely in children with MS. We present a case of MS in 10-year-old boy, who had ... Isolated oculomotor nerve palsy is found rarely in children with MS. We present a case of MS in 10-year-old boy, who had ... Taksande, A., Meshram, R., Lohakare, A. A Rare Presentation of Isolated Oculomotor Nerve Palsy due to Multiple Sclerosis in a ... "A Rare Presentation of Isolated Oculomotor Nerve Palsy due to Multiple Sclerosis in a Child". International Journal of ...

*  "A child with intra-orbital oculomotor nerve schwannoma without neurofi" by Muhammad Shahzad Shamim, Muhammad Ehsan Bari et al.

Shamim, M., Bari, M., Chisti, K., Abbas, A. (2008). A child with intra-orbital oculomotor nerve schwannoma without ...

*  Single-center experience with TruFill platinum coils for the embolization of cerebral aneurysms.

Previous Document: Oculomotor nerve palsy evaluated by diffusion-tensor tractography.. Next Document: Variables contributing to ...

*  Duane syndrome type 1 | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program

Oculomotor nerve palsy. Very frequent (present in 80%-99% of cases). Short palpebral fissure. Very frequent (present in 80%-99 ... Unfortunately, surgery does not restore function to the affected nerve and muscle, and no surgical technique has been ...

*  plate13

OcNr Radiations of the Oculomotor Nerve. VII Lamina VII. GPe Globus Pallidus, External segment. OcNu Oculomotor Nucleus. VL ... IXn Glossopharyngeal Nerve. RaNu Raphe Nucleus. AVC Arterial Vasocorona. LatVen, B Lateral Ventricle, Body. RetSp ... AbdNr Abducens Nerve. ICP Inferior Cerebellar Peduncle. PMChA posteromedial Choroidal Artery. AbdNu Abducens Nucleus. II Lamina ... HyNr Radiations of Hypoglossal Nerve. PCA Posterior Cerebral Artery. VTA Ventral Tegmental Area. ...

*  Arnold B. Etame | Moffitt Cancer Center

Acute expansion of an asymptomatic posterior communicating artery aneurysm resulting in oculomotor nerve palsy. BMJ Case Rep. ...

*  Sphenoethmoidal suture | Radiology Reference Article | Radiopaedia.org

oculomotor nerve (CN III). * trochlear nerve (CN IV). * trigeminal nerve (mnemonic) (CN V) *ophthalmic division *tentorial ...

*  Retropharyngeal space | Radiology Reference Article | Radiopaedia.org

oculomotor nerve (CN III). * trochlear nerve (CN IV). * trigeminal nerve (mnemonic) (CN V) *ophthalmic division *tentorial ...

Oculomotor nerve palsyOculomotor nucleus: The fibers of the oculomotor nerve arise from a nucleus in the midbrain, which lies in the gray substance of the floor of the cerebral aqueduct and extends in front of the aqueduct for a short distance into the floor of the third ventricle. From this nucleus the fibers pass forward through the tegmentum, the red nucleus, and the medial part of the substantia nigra, forming a series of curves with a lateral convexity, and emerge from the oculomotor sulcus on the medial side of the cerebral peduncle.OphthalmoparesisTrochlear nerve: The trochlear nerve,, ) come from Ancient Greek also called the fourth cranial nerve or cranial nerve IV, is a motor nerve] (a [[somatic nervous system|somatic efferent nerve) that innervates only a single muscle: the superior oblique muscle of the eye, which operates through the pulley-like trochlea.Abducens nucleus: The abducens nucleus is the originating nucleus from which the abducens nerve (VI) emerges - a cranial nerve nucleus. This nucleus is located beneath the fourth ventricle in the caudal portion of the pons, medial to the sulcus limitans.AnisocoriaSoy ink: Soy ink is a kind of ink made from soybeans. As opposed to traditional petroleum-based ink, soy-based ink is more environmentally friendly, might provide more accurate colors, and makes it easier to recycle paper .Marcus Gunn phenomenonInferior rectus muscle: The inferior rectus muscle is a muscle in the orbit.Templebryan Stone Circle: [1.jpg|thumb|300px|right|Templebryan: Nine stones were recorded as standing in the eighteenth century.Surgical scissors: Surgical scissors are surgical instruments usually used for cutting. They include bandage scissors, dissecting scissors, iris scissors, operating scissors, stitch scissors, tenotomy scissors, Metzenbaum scissors, plastic surgery scissors, and Mayo scissors.Task-invoked pupillary responseInfectious intracranial aneurysm: An infectious intracranial aneurysm (IIA, also called mycotic aneurysm) is a cerebral aneurysm that is caused by infection of the cerebral arterial wall.Sciatic nerve: The sciatic nerve (; also called ischiadic nerve, ischiatic nerve) is a large nerve in humans and other animals. It begins in the lower back and runs through the buttock and down the lower limb.XYZ file format: The XYZ file format is a chemical file format. There is no formal standard and several variations exist, but a typical XYZ format specifies the molecule geometry by giving the number of atoms with Cartesian coordinates that will be read on the first line, a comment on the second, and the lines of atomic coordinates in the following lines.Tadpole pupil: The eye is made up of the sclera, the iris, and the pupil, a black hole located at the center of the eye with the main function of allowing light to pass to the retina. Due to certain muscle spasms in the eye, the pupil can resemble a tadpole, which consists of a circular body, no arms or legs, and a tail.Endoneurium: The endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or Henle's sheath) is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber. Its component cells are called endoneurial cells.Optic nerve tumor: An optic nerve melanocytoma is a tumor made up of melanocytes and melanin. These tumors are typically a benign; they can grow, but rarely transform into a malignancy.Nerve fiber layer: The retinal nerve fiber layer (nerve fiber layer, stratum opticum, RNFL) is formed by the expansion of the fibers of the optic nerve; it is thickest near the porus opticus, gradually diminishing toward the ora serrata.Ganglion cellHyperintensityDissection puzzle: A dissection puzzle, also called a transformation puzzle or Richter Puzzle, is a tiling puzzle where a set of pieces can be assembled in different ways to produce two or more distinct geometric shapes. The creation of new dissection puzzles is also considered to be a type of dissection puzzle.Neuroregeneration: Neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products. Such mechanisms may include generation of new neurons, glia, axons, myelin, or synapses.Spinal decompression: Spinal decompression is the relief of pressure on one or many pinched nerves (neural impingement) of the spinal column.Nerve blockNerve biopsyMedian nerve: The median nerve is a nerve in humans and other animals in the upper limb. It is one of the five main nerves originating from the brachial plexus.Electroneuronography: Electroneuronography or electroneurography (ENoG) is a neurological non-invasive test that was first described by Esslen and Fisch in 1979 and is used to examine the integrity and conductivity of a peripheral nerve. It consists of a brief electrical stimulation of the nerve in one point underneath the skin, and at the same time recording the electrical activity (compound action potentials) at another point of the nerve's trajectory in the body.Bobby Crush: Bobby Crush (born Robert Nicholas Crush, 23 March 1954) is an English pianist, songwriter, actor and television presenter, originally from Leyton in East London.Neurotmesis: Neurotmesis (in Greek tmesis signifies "to cut") is part of Seddon's classification scheme used to classify nerve damage. It is the most serious nerve injury in the scheme.Martin-Gruber Anastomosis: The Martin-Gruber Anastomosis (or Martin-Gruber Connection) is a communicating nerve branch between the median nerve and the ulnar nerve in the forearm. It is the most common anastomotic anomaly that occurs between these two nerves.

(1/219) Recovery of the vestibulocolic reflex after aminoglycoside ototoxicity in domestic chickens.

Avian auditory and vestibular hair cells regenerate after damage by ototoxic drugs, but until recently there was little evidence that regenerated vestibular hair cells function normally. In an earlier study we showed that the vestibuloocular reflex (VOR) is eliminated with aminoglycoside antibiotic treatment and recovers as hair cells regenerate. The VOR, which stabilizes the eye in the head, is an open-loop system that is thought to depend largely on regularly firing afferents. Recovery of the VOR is highly correlated with the regeneration of type I hair cells. In contrast, the vestibulocolic reflex (VCR), which stabilizes the head in space, is a closed-loop, negative-feedback system that seems to depend more on irregularly firing afferent input and is thought to be subserved by different circuitry than the VOR. We examined whether this different reflex also of vestibular origin would show similar recovery after hair cell regeneration. Lesions of the vestibular hair cells of 10-day-old chicks were created by a 5-day course of streptomycin sulfate. One day after completion of streptomycin treatment there was no measurable VCR gain, and total hair cell density was approximately 35% of that in untreated, age-matched controls. At 2 wk postlesion there was significant recovery of the VCR; at this time two subjects showed VCR gains within the range of control chicks. At 3 wk postlesion all subjects showed VCR gains and phase shifts within the normal range. These data show that the VCR recovers before the VOR. Unlike VOR gain, recovering VCR gain correlates equally well with the density of regenerating type I and type II vestibular hair cells, except at high frequencies. Several factors other than hair cell regeneration, such as length of stereocilia, reafferentation of hair cells, and compensation involving central neural pathways, may be involved in behavioral recovery. Our data suggest that one or more of these factors differentially affect the recovery of these two vestibular reflexes.  (+info)

(2/219) Microstimulation of the lateral wall of the intraparietal sulcus compared with the frontal eye field during oculomotor tasks.

We compared the effects of intracortical microstimulation (ICMS) of the lateral wall of the intraparietal sulcus (LIP) with those of ICMS of the frontal eye field (FEF) on monkeys performing oculomotor tasks. When ICMS was applied during a task that involved fixation, contraversive saccades evoked in the LIP and FEF appeared similar. When ICMS was applied to the FEF at the onset of voluntary saccades, the evoked saccades collided with the ongoing voluntary saccade so that the trajectory of voluntary saccade was compensated by the stimulus. Thus the resultant saccade was redirected and came close to the endpoint of saccades evoked from the fixation point before the start of voluntary saccade. In contrast, when ICMS was applied to the LIP at the onset of voluntary saccades, the resultant saccade followed a trajectory that was different from that evoked from the FEF. In that case, the colliding saccades were redirected toward an endpoint that was close to the endpoint of saccades evoked when animals were already fixating at the target of the voluntary saccade. This finding suggests that the colliding saccade was directed toward an endpoint calculated with reference to the target of the voluntary saccade. We hypothesize that, shortly before initiation of voluntary saccades, a dynamic process occurs in the LIP so that the reference point for calculating the saccade target shifts from the fixation point to the target of a voluntary saccade. Such predictive updating of reference points seems useful for immediate reprogramming of upcoming saccades that can occur in rapid succession.  (+info)

(3/219) Oculomotor tracking in two dimensions.

Results from studies of oculomotor tracking in one dimension have indicated that saccades are driven primarily by errors in position, whereas smooth pursuit movements are driven primarily by errors in velocity. To test whether this result generalizes to two-dimensional tracking, we asked subjects to track a target that moved initially in a straight line then changed direction. We found that the general premise does indeed hold true; however, the study of oculomotor tracking in two dimensions provides additional insight. The first saccade was directed slightly in advance of target location at saccade onset. Thus its direction was related primarily to angular positional error. The direction of the smooth pursuit movement after the saccade was related linearly to the direction of target motion with an average slope of 0.8. Furthermore the magnitude and direction of smooth pursuit velocity did not change abruptly; consequently the direction of smooth pursuit appeared to rotate smoothly over time.  (+info)

(4/219) Effect of reversible inactivation of macaque lateral intraparietal area on visual and memory saccades.

Previous studies from our laboratory identified a parietal eye field in the primate lateral intraparietal sulcus, the lateral intraparietal area (area LIP). Here we further explore the role of area LIP in processing saccadic eye movements by observing the effects of reversible inactivation of this area. One to 2 microl of muscimol (8 mg/ml) were injected at locations where saccade-related activities were recorded for each lesion experiment. After the muscimol injection we observed in two macaque monkeys consistent effects on both the metrics and dynamics of saccadic eye movements at many injection sites. These effects usually took place within 10-30 min and disappeared after 5-6 h in most cases and certainly when tested the next day. After muscimol injection memory saccades directed toward the contralesional and upper space became hypometric, and in one monkey those to the ipsilesional space were slightly but significantly hypermetric. In some cases, the scatter of the end points of memory saccades was also increased. On the other hand, the metrics of visual saccades remained relatively intact. Latency for both visual and memory saccades toward the contralesional space was increased and in many cases displayed a higher variance after muscimol lesion. At many injection sites we also observed an increase of latency for visual and memory saccades toward the upper space. The peak velocities for memory saccades toward the contralesional space were decreased after muscimol injection. The peak velocities of visual saccades were not significantly different from those of the controls. The duration of saccadic eye movements either to the ipsilesional or contralesional space remained relatively the same for both visual and memory saccades. Overall these results demonstrated that we were able to selectively inactivate area LIP and observe effects on saccadic eye movements. Together with our previous recording studies these results futher support the view that area LIP plays a direct role in processing incoming sensory information to program saccadic eye movements. The results are consistent with our unit recording data and microstimulation studies, which suggest that area LIP represents contralateral space and also has a bias for the upper visual field.  (+info)

(5/219) Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC.

Studies on the cellular mechanisms of working memory demonstrated that neurons in dorsolateral prefrontal cortex (dPFC) exhibit directionally tuned activity during an oculomotor delayed response. To determine the particular contributions of pyramidal cells and interneurons to spatial tuning in dPFC, we examined both individually and in pairs the tuning properties of regular-spiking (RS) and fast-spiking (FS) units that represent putative pyramidal cells and interneurons, respectively. Our main finding is that FS units possess spatially tuned sensory, motor, and delay activity (i. e., "memory fields") similar to those found in RS units. Furthermore, when recorded simultaneously at the same site, the majority of neighboring neurons, whether FS or RS, displayed isodirectional tuning, i.e., they shared very similar tuning angles for the sensory and delay phases of the task. As the trial entered the response phase of the task, many FS units shifted their direction of tuning and became cross-directional to adjacent RS units by the end of the trial. These results establish that a large part of inhibition in prefrontal cortex is spatially oriented rather than being untuned and simply regulating the threshold response of pyramidal cell output. Moreover, the isodirectional tuning between adjacent neurons supports a functional microcolumnar organization in dPFC for spatial memory fields similar to that found in other areas of cortex for sensory receptive fields.  (+info)

(6/219) MR imaging of Dejerine-Sottas disease.

We report the MR findings in two patients with clinically and histologically proved Dejerine-Sottas disease. One patient had spinal involvement with multiple thickened and clumped nerve roots of the cauda equina; the second had multiple enlarged and enhancing cranial nerves. Although these findings are not specific for Dejerine-Sottas disease, they are suggestive of the diagnosis, which is further corroborated with history and confirmed with sural nerve biopsy and laboratory studies.  (+info)

(7/219) Stereotactic radiosurgery for cavernous sinus cavernous hemangioma--case report.

A 40-year-old female presented with cavernous sinus cavernous hemangioma manifesting as left abducens and trigeminal nerve pareses. Magnetic resonance imaging revealed a left cavernous sinus tumor. The tumor was partially removed. Histological examination of the specimen confirmed cavernous hemangioma. Radiosurgery was performed using the gamma knife. The tumor markedly decreased in size after radiosurgery and morbidity was avoided. Cavernous sinus cavernous hemangiomas may be difficult to treat surgically due to intraoperative bleeding and cranial nerve injury. Stereotactic radiosurgery can be used either as an adjunct treatment to craniotomy, or as the primary treatment for small cavernous sinus cavernous hemangioma.  (+info)

(8/219) Model for the translational vestibuloocular reflex (VOR).

The function of the translational vestibuloocular reflex (tVOR) and the angular vestibuloocular reflex (aVOR) is to stabilize images on the retina during translational and rotational motion, respectively. It has generally been assumed that these two reflexes differ in their central processing because they differ significantly in their primary afferent behavior and characteristics at the motor level. So far, models of the tVOR have focused on the type of processing that the primary afferent signal must undergo before reaching the neural integrator. Here, we propose a model that does not require any prefiltering. It is known that the eye plant requires signals in phase with velocity and position. We propose that the velocity signal is obtained directly from the neural integrator, whereas the position signal is obtained directly from the primary afferents synapsing onto the oculomotor nuclei. This design proved sufficient to simulate eye movements in response to translational motion.  (+info)


  • A Rare Presentation of Isolated Oculomotor Nerve Palsy due to Multiple Sclerosis in a Child', International Journal of Pediatrics , 5(8), pp. 5525-5529. (ac.ir)
  • Isolated oculomotor nerve palsy is found rarely in children with MS. We present a case of MS in 10-year-old boy, who had bilateral ptosis associated with medial gaze restriction. (ac.ir)
  • Oculomotor nerve palsy evaluated by diffusion-tensor tractography. (biomedsearch.com)

cranial nerves

  • The two bellies of the muscle have different embryonic origins and hence are supplied by different cranial nerves . (radiopaedia.org)

Trigeminal Nerve

  • The nasopalatine nerve (also known as the long sphenopalatine nerve ) is a branch of the maxillary division of the trigeminal nerve and contributes to the pterygopalatine ganglion . (radiopaedia.org)


  • It leaves the fossa inferomedially through the sphenopalatine foramen with the posterior superior nasal nerves to enter the nasal cavity just being the superior nasal meatus where it passes along the roof of the nose and into the nasal septum, where it may groove the vomer . (radiopaedia.org)
  • The left nasopalatine nerve can pass through the anterior incisive foramen and the right nasopalatine nerve can pass through the posterior incisive foramen when an anterior and posterior foramen exists for the incisive foramen. (radiopaedia.org)
  • The posterior superior nasal nerves may branch of the nasopalatine nerve just before or after it passes through the sphenopalatine foramen. (radiopaedia.org)


  • The nasopalatine nerve divides off the maxillary division just after emerging from the foramen rotundum to enter the pterygopalatine fossa . (radiopaedia.org)


  • A child with intra-orbital oculomotor nerve schwannoma without neurofi" by Muhammad Shahzad Shamim, Muhammad Ehsan Bari et al. (aku.edu)