Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.
Nitroso compounds are organic or inorganic substances containing the nitroso functional group, which consists of a nitrogen atom bonded to an oxygen atom through a single covalent bond, often abbreviated as -NO.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.
A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
A naphthalene derivative with carcinogenic action.
A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.
Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.
Diethylamines are organic compounds consisting of two ethyl groups bonded to an amino nitrogen atom, with the general formula (C2H5)2NH, known for their foul odor and use as chemical intermediates in various industrial applications, but notably not associated with medical definitions unless referring to potential substance abuse or intoxication.
Inorganic oxides that contain nitrogen.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Compounds containing the -SH radical.
Oxidoreductases that are specific for the reduction of NITRATES.
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclature, 1992) EC 1.
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Derivatives of formic acids. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are formed with a single carbon carboxy group.
An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Life or metabolic reactions occurring in an environment containing oxygen.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Regular course of eating and drinking adopted by a person or animal.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. (1/286)

In cultured human endothelial cells, physiological levels of NO prevent apoptosis and interfere with the activation of the caspase cascade. In vitro data have demonstrated that NO inhibits the activity of caspase-3 by S-nitrosation of the enzyme. Here we present evidence for the in vivo occurrence and functional relevance of this novel antiapoptotic mechanism. To demonstrate that the cysteine residue Cys-163 of caspase-3 is S-nitrosated, cells were transfected with the Myc-tagged p17 subunit of caspase-3. After incubation of the transfected cells with different NO donors, Myc-tagged p17 was immunoprecipitated with anti-Myc antibody. S-Nitrosothiol was detected in the immunoprecipitate by electron spin resonance spectroscopy after liberation and spin trapping of NO by N-methyl-D-glucamine-dithiocarbamate-iron complex. Transfection of cells with a p17 mutant, where the essential Cys-163 was mutated into alanine, completely prevented S-nitrosation of the enzyme. As a functional correlate, in human umbilical vein endothelial cells the NO donors sodium nitroprusside or PAPA NONOate (50 microM) significantly reduced the increase in caspase-3-like activity induced by overexpressing caspase-3 by 75 and 70%, respectively. When human umbilical vein endothelial cells were cotransfected with beta-galactosidase, morphological analysis of stained cells revealed that cell death induction by overexpression of caspase-3 was completely suppressed in the presence of sodium nitroprusside, PAPA NONOate, or S-nitroso-L-cysteine (50 microM). Thus, NO supplied by exogenous NO donors serves in vivo as an antiapoptotic regulator of caspase activity via S-nitrosation of the Cys-163 residue of caspase-3.  (+info)

The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces. (2/286)

OBJECTIVES: We studied the antithrombotic effect of coating glass, collagen and metal stent surfaces with bovine serum albumin (BSA) covalently modified to carry S-NO functional groups denoted (pS-NO-BSA). METHODS: Video-enhanced light microscopy was used to visualize canine blood platelet adhesion and aggregation in a parallel plate glass chamber. Platelet adhesion was observed for 60 min on glass, glass coated with BSA, glass coated with pS-NO-BSA, collagen I (CO) surface, CO coated with BSA and CO coated with pS-NO-BSA. We also coated Palmaz-Shatz (P-S) stents with pS-NO-BSA. Coated and uncoated stents were then immersed in porcine platelet-rich plasma for two min and the platelet cyclic GMP level was measured. In six anesthetized pigs, coated and uncoated stents were placed in the carotid arteries and [111In]-labeled platelets were circulated for 2 h. The stented arteries were then removed and placed in a gamma well counter. RESULTS: There was significantly less platelet attachment, adhesion and aggregation on the pS-NO-BSA coated surfaces compared with the BSA coated and uncoated surfaces. The pS-NO-BSA coating increased the platelet cGMP levels to 5.9+/-0.7 pmoles/10(8) platelets compared with 2.7+/-0.9 pmoles/10(8) platelets for control (p < 0.01). The average gamma ray count from [111In]-labeled platelets that attached to the coated stents was 90,000+/-42,000/min and 435,000+/-290,000/min for the uncoated stents (p < 0.01). CONCLUSIONS: The pS-NO-BSA coating of thrombogenic surfaces reduces platelet adhesion and aggregation, possibly by increasing the platelet cGMP. This inhibitory effect appears to be a consequence of the direct antiplatelet actions of NO combined with the antiadhesive properties of albumin.  (+info)

Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite. (3/286)

This review is concerned mainly with the three redox-related, but chemically distinct, species NO-, NO. and NO+, with greatest emphasis being placed on the chemistry and biology of the nitroxyl ion. Biochemical routes for the formation of nitroxyl ion and methods for showing the intermediacy of this species are discussed, together with chemical methods for generating nitroxyl ion in solution. Reactions of nitroxyl ion with NO., thiols, iron centres in haem and with dioxygen are reviewed The significance of the reaction between NO- and dioxygen as a source of peroxynitrite is assessed, and attention drawn to the possible significance of the spin state of the nitroxyl ion in this context. The biological significance of nitrosation and the importance of S-nitrosothiols and certain metal nitrosyl complexes as carriers of NO+ at physiological pH is stressed. Some features in the chemistry of peroxynitrite are noted.  (+info)

Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. (4/286)

S-Nitrosation of cysteine beta93 in hemoglobin (S-nitrosohemoglobin (SNO-Hb)) occurs in vivo, and transnitrosation reactions of deoxygenated SNO-Hb are proposed as a mechanism leading to release of NO and control of blood flow. However, little is known of the oxygen binding properties of SNO-Hb or the effects of oxygen on transnitrosation between SNO-Hb and the dominant low molecular weight thiol in the red blood cell, GSH. These data are important as they would provide a biochemical framework to assess the physiological function of SNO-Hb. Our results demonstrate that SNO-Hb has a higher affinity for oxygen than native Hb. This implies that NO transfer from SNO-Hb in vivo would be limited to regions of extremely low oxygen tension if this were to occur from deoxygenated SNO-Hb. Furthermore, the kinetics of the transnitrosation reactions between GSH and SNO-Hb are relatively slow, making transfer of NO+ from SNO-Hb to GSH less likely as a mechanism to elicit vessel relaxation under conditions of low oxygen tension and over the circulatory lifetime of a given red blood cell. These data suggest that the reported oxygen-dependent promotion of S-nitrosation from SNO-Hb involves biochemical mechanisms that are not intrinsic to the Hb molecule.  (+info)

Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. (5/286)

The ability of human liver cytochrome P450s to metabolize the environmental carcinogen N-nitrosodi-n-propylamine (NDPA) was investigated. The maximum rate of NDPA depropylation in seven human liver microsomal samples was 1.15 nmol/min/mg (range 0.53-2.60). Troleandomycin, a P450 3A4/5 inhibitor, inhibited depropylation modestly (10-60%) in three of seven samples. Diethyldithiocarbamic acid, a potent 2E1 inhibitor, and a 2E1 inhibitory monoclonal antibody (mAb) inhibited the reaction in all samples (23 to almost 100%). No significant inhibition was observed with the 2C9 inhibitor sulfaphenazole or with mAbs to 3A4, 2A6 and 2D6. The 2C8/9/18/19 mAb inhibited depropylation in one sample by approximately 25% and approximately 25% of the activity in another sample could not be accounted for by the inhibitors. Denitrosation of NDPA by three of the microsomal samples exhibited low K(m) values (51-86 microM) while two of these also had high K(m) values (2.6 and 4.6 mM). Purified human P450 2B6 and 3A4 and human P450 2A6, 2C8, 2C9 and 2D6 membranes had high K(m) values relative to their maximum turnover rates and are unlikely to participate in NDPA metabolism at micromolar concentrations. Conversely, purified rabbit 2E1 exhibited K(m) and V(max) values for depropylation of 52 microM and 13.4 nmol propionaldehyde/min/nmol P450, respectively. Values for denitrosation were 66 microM and 1.44 nmol nitrite/min/nmol P450, respectively. The toxicity of NDPA in transfected human liver epithelial cells expressing 2E1 was dose dependent down to 50 microM. No toxicity was observed in control cells or those expressing 2A6. These results indicate that 2E1 is the major human liver microsomal isoform responsible for NDPA metabolism at low micromolar concentrations. We also show that purified P450s catalyze the denitrosation of NDPA at approximately 10-20% of the rate of depropylation and K(m) values for both reactions are the same for each isozyme. This is consistent with the formation of an initial intermediate common to both pathways, presumably an alpha-nitrosamino radical.  (+info)

Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress. (6/286)

Protein S-glutathiolation, the reversible covalent addition of glutathione to cysteine residues on target proteins, is emerging as a candidate mechanism by which both changes in the intracellular redox state and the generation of reactive oxygen and nitrogen species may be transduced into a functional response. This review will provide an introduction to the concepts of oxidative and nitrosative stress and outline the molecular mechanisms of protein regulation by oxidative and nitrosative thiol-group modifications. Special attention will be paid to recently published work supporting a role for S-glutathiolation in stress signalling pathways and in the adaptive cellular response to oxidative and nitrosative stress. Finally, novel insights into the molecular mechanisms of S-glutathiolation as well as methodological problems related to the interpretation of the biological relevance of this post-translational protein modification will be discussed.  (+info)

Nitrosation and oxidation in the regulation of gene expression. (7/286)

A growing body of evidence suggests that the cellular response to oxidative and nitrosative stress is primarily regulated at the level of transcription. Posttranslational modification of transcription factors may provide a mechanism by which cells sense these redox changes. In bacteria, for example, OxyR senses redox-related changes via oxidation or nitrosylation of a free thiol in the DNA binding region. This mode of regulation may serve as a paradigm for redox-sensing by eukaryotic transcription factors as most-including NF-kappaB, AP-1, and p53-contain reactive thiols in their DNA binding regions, the modification of which alters binding in vitro. Several of these transcription factors have been found to be sensitive to both reactive oxygen species and nitric oxide-related species in vivo. It remains entirely unclear, however, if oxidation or nitrosylation of eukaryotic transcription factors is an important mode of regulation, or whether transcriptional activating pathways are principally controlled at other redox-sensitive levels.-Marshall, H. E., Merchant, K., Stamler, J. S. Nitrosation and oxidation in the regulation of gene expression.  (+info)

The role of nitric oxide in neoplastic transformation of C3H 10T1/2 embryonic fibroblasts. (8/286)

Nitric oxide synthase inhibitors block the neoplastic transformation of C3H 10T1/2 cells in vitro. Evidence presented herein suggests that they mediate their effects early in the carcinogenic process as brief treatment with the NOS inhibitor aminoguanidine (AG) during log phase cell growth (initiation phase) is sufficient to block foci formation. In contrast, treatment initiated after formation of a confluent monolayer was associated with diminished protection, while treatment commencing late in the promotional phase had no protective effect and appeared to enhance the number and stage of foci observed. These findings suggest that while AG treatment can inhibit transformation during the early promotional phase, it most effectively inhibits transformation during the initiation phase. In general AG enhanced growth of both normal and tumor cells, suggesting that effects on growth were unrelated to its anti-transformation properties, however, these effects could be related to the effect on tumor cell stage noted above. Although induction of inducible nitric oxide synthase (iNOS) by treatment with LI during the last 2 weeks of the assay was associated with enhanced transformation, the efficacy of AG in protecting against transformation was not clearly associated with substantial reductions in NO synthesis. The data suggest that AG inhibits transformation early in the transformation process independently of iNOS inhibition and that AG may have deleterious effects late in the process, possibly through stimulation of tumor cell growth.  (+info)

Nitrosation is a chemical reaction that involves the addition of a nitrosonium ion (NO+) to another molecule. In the context of medicine, particularly in relation to gastroenterology and oncology, nitrosation is often discussed in terms of its potential role in the formation of carcinogenic N-nitroso compounds (NOCs).

These NOCs can be formed when nitrites (compounds containing a nitrite ion, NO2-) or nitrous acid (HNO2) react with secondary amines or other amino compounds under acidic conditions. This reaction can occur in the stomach after the ingestion of foods or beverages that contain both nitrites and amines, such as processed meats and certain alcoholic beverages.

The formation of NOCs has been associated with an increased risk of various types of cancer, including gastric and esophageal cancer. However, it's important to note that the relationship between nitrosation and cancer is complex and not fully understood, as other factors such as the presence of antioxidants in the diet can also influence the formation of NOCs.

Nitroso compounds are a class of chemical compounds that contain a nitroso functional group, which is composed of a nitrogen atom bonded to an oxygen atom with a single covalent bond. The general formula for nitroso compounds is R-N=O, where R represents an organic group such as an alkyl or aryl group.

Nitroso compounds are known to be reactive and can form under various physiological conditions. They have been implicated in the formation of carcinogenic substances and have been linked to DNA damage and mutations. In the medical field, nitroso compounds have been studied for their potential use as therapeutic agents, particularly in the treatment of cancer and cardiovascular diseases. However, their use is limited due to their potential toxicity and carcinogenicity.

It's worth noting that exposure to high levels of nitroso compounds can be harmful to human health, and may cause respiratory, dermal, and ocular irritation, as well as potential genotoxic effects. Therefore, handling and storage of nitroso compounds should be done with caution, following appropriate safety guidelines.

Nitrosamines are a type of chemical compound that are formed by the reaction between nitrous acid (or any nitrogen oxide) and secondary amines. They are often found in certain types of food, such as cured meats and cheeses, as well as in tobacco products and cosmetics.

Nitrosamines have been classified as probable human carcinogens by the International Agency for Research on Cancer (IARC). Exposure to high levels of nitrosamines has been linked to an increased risk of cancer, particularly in the digestive tract. They can also cause DNA damage and interfere with the normal functioning of cells.

In the medical field, nitrosamines have been a topic of concern due to their potential presence as contaminants in certain medications. For example, some drugs that contain nitrofurantoin, a medication used to treat urinary tract infections, have been found to contain low levels of nitrosamines. While the risk associated with these low levels is not well understood, efforts are underway to minimize the presence of nitrosamines in medications and other products.

Nitrates are chemical compounds that consist of a nitrogen atom bonded to three oxygen atoms (NO3-). In the context of medical science, nitrates are often discussed in relation to their use as medications or their presence in food and water.

As medications, nitrates are commonly used to treat angina (chest pain) caused by coronary artery disease. Nitrates work by relaxing and widening blood vessels, which improves blood flow and reduces the workload on the heart. Some examples of nitrate medications include nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.

In food and water, nitrates are naturally occurring compounds that can be found in a variety of vegetables, such as spinach, beets, and lettuce. They can also be present in fertilizers and industrial waste, which can contaminate groundwater and surface water sources. While nitrates themselves are not harmful, they can be converted into potentially harmful compounds called nitrites under certain conditions, particularly in the digestive system of young children or in the presence of bacteria such as those found in unpasteurized foods. Excessive levels of nitrites can react with hemoglobin in the blood to form methemoglobin, which cannot transport oxygen effectively and can lead to a condition called methemoglobinemia.

Sodium nitrite is an inorganic compound with the chemical formula NaNO2. Medically, it is used as a vasodilator and an antidote for cyanide poisoning. It is a white to slightly yellowish crystalline powder that is very soluble in water and moderately soluble in alcohol. In solution, it is easily oxidized to sodium nitrate (NaNO3), which is stable and less toxic.

In the food industry, sodium nitrite is used as a preservative and coloring agent in meat and fish products. It helps prevent the growth of harmful bacteria, such as Clostridium botulinum, which can cause botulism. However, under certain conditions, sodium nitrite can react with proteins in food to form potentially carcinogenic compounds, so its use is regulated.

S-Nitrosoglutathione (GSNO) is defined as a type of nitrosothiol, which is a class of compounds containing a nitroso (−NO) group attached to a sulfur atom. Specifically, GSNO is the result of the attachment of a nitric oxide (NO) molecule to the sulfur atom of the tripeptide glutathione (GSH). This compound has been the subject of extensive research due to its potential role in the regulation of various biological processes, including cell signaling, vasodilation, and neurotransmission, among others. It is also known to have antioxidant properties and to play a role in the immune response. However, it should be noted that abnormal levels of GSNO have been associated with various pathological conditions, such as cancer, neurodegenerative diseases, and cardiovascular disorders.

In a medical context, nitrites are typically referred to as organic compounds that contain a functional group with the formula R-N=O, where R represents an alkyl or aryl group. They are commonly used in medicine as vasodilators, which means they widen and relax blood vessels, improving blood flow and lowering blood pressure.

One example of a nitrite used medically is amyl nitrite, which was previously used to treat angina pectoris, a type of chest pain caused by reduced blood flow to the heart muscle. However, its use has largely been replaced by other medications due to safety concerns and the availability of more effective treatments.

It's worth noting that inorganic nitrites, such as sodium nitrite, are also used in medicine for various purposes, including as a preservative in food and as a medication to treat cyanide poisoning. However, these compounds have different chemical properties and uses than organic nitrites.

2-Naphthylamine is a crystalline solid organic compound that is classified as a primary aromatic amine. Its chemical formula is C10H9N. It is an intensely orange-red to reddish-brown substance that is slightly soluble in water and more soluble in organic solvents.

2-Naphthylamine is produced by the reduction of 2-naphthol or its derivatives. Historically, it was used as an intermediate in the synthesis of azo dyes and other chemical compounds. However, due to its toxicity and carcinogenicity, its use has been largely discontinued in many industries.

Exposure to 2-Naphthylamine can occur through inhalation, skin contact, or ingestion, and it has been associated with an increased risk of bladder cancer and other health effects. Therefore, appropriate safety measures must be taken when handling this compound, including the use of personal protective equipment (PPE) such as gloves, lab coats, and eye protection.

S-Nitrosothiols (SNOs) are a type of organic compound that contain a nitroso (-NO) group attached to a sulfur atom in a thiol (-SH) group. They are formed by the reaction between nitric oxide (NO) and low molecular weight thiols, such as cysteine or glutathione. S-Nitrosothiols play an important role in the regulation of various cellular processes, including signal transduction, gene expression, and protein function. They also have been implicated in the pathogenesis of several diseases, such as cancer, neurodegenerative disorders, and cardiovascular disease. SNOs can be measured in biological samples, such as blood or tissues, to evaluate nitrosative stress and oxidative damage.

Postgastrectomy syndromes refer to a group of clinical manifestations that can occur as complications or sequelae following a gastrectomy, which is the surgical removal of all or part of the stomach. These syndromes are relatively common and can have a significant impact on the patient's quality of life.

There are several types of postgastrectomy syndromes, including:

1. Dumping syndrome: This occurs when the remaining portion of the stomach is unable to adequately regulate the passage of food into the small intestine, leading to symptoms such as nausea, vomiting, abdominal cramps, diarrhea, dizziness, and sweating.
2. Gastroparesis: This is a condition where the stomach is unable to empty properly due to decreased motility, leading to symptoms such as bloating, nausea, vomiting, and early satiety.
3. Nutritional deficiencies: Following gastrectomy, there can be malabsorption of certain nutrients, including vitamin B12, iron, calcium, and folate, leading to anemia, osteoporosis, and other health problems.
4. Afferent loop syndrome: This is a rare complication that occurs when the afferent loop, which carries digestive enzymes from the pancreas and bile from the liver to the small intestine, becomes obstructed or narrowed, leading to symptoms such as abdominal pain, nausea, vomiting, and jaundice.
5. Alkaline reflux gastritis: This occurs when the alkaline contents of the small intestine reflux into the remnant stomach, causing inflammation and ulceration.
6. Bile reflux: This is a condition where bile from the small intestine flows back into the stomach, leading to symptoms such as abdominal pain, nausea, vomiting, and heartburn.

Treatment of postgastrectomy syndromes depends on the specific type and severity of the syndrome, and may include dietary modifications, medication, or surgical intervention.

Diethylamines are organic compounds that consist of a nitrogen atom bonded to two ethyl groups and one hydrogen atom. The chemical formula for diethylamine is (C2H5)2NH, and it is a colorless liquid with an unpleasant fishy odor. It is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Diethylamines can also be found as byproducts in some industrial processes and are produced naturally by certain plants and animals.

Diethylamines can have stimulant effects on the central nervous system and can cause symptoms such as excitement, restlessness, and confusion. In high concentrations or with prolonged exposure, diethylamines can be toxic and may cause respiratory, cardiovascular, and neurological problems. Therefore, it is important to handle diethylamines with care and use appropriate safety measures when working with them.

Nitrogen oxides (NOx) are a group of highly reactive gases, primarily composed of nitric oxide (NO) and nitrogen dioxide (NO2). They are formed during the combustion of fossil fuels, such as coal, oil, gas, or biomass, and are emitted from various sources, including power plants, industrial boilers, transportation vehicles, and residential heating systems. Exposure to NOx can have adverse health effects, particularly on the respiratory system, and contribute to the formation of harmful air pollutants like ground-level ozone and fine particulate matter.

Nitric oxide (NO) is a molecule made up of one nitrogen atom and one oxygen atom. In the body, it is a crucial signaling molecule involved in various physiological processes such as vasodilation, immune response, neurotransmission, and inhibition of platelet aggregation. It is produced naturally by the enzyme nitric oxide synthase (NOS) from the amino acid L-arginine. Inhaled nitric oxide is used medically to treat pulmonary hypertension in newborns and adults, as it helps to relax and widen blood vessels, improving oxygenation and blood flow.

Sulfhydryl compounds, also known as thiol compounds, are organic compounds that contain a functional group consisting of a sulfur atom bonded to a hydrogen atom (-SH). This functional group is also called a sulfhydryl group. Sulfhydryl compounds can be found in various biological systems and play important roles in maintaining the structure and function of proteins, enzymes, and other biomolecules. They can also act as antioxidants and help protect cells from damage caused by reactive oxygen species. Examples of sulfhydryl compounds include cysteine, glutathione, and coenzyme A.

Nitrate reductases are a group of enzymes that catalyze the reduction of nitrate (NO3-) to nitrite (NO2-). This process is an essential part of the nitrogen cycle, where nitrate serves as a terminal electron acceptor in anaerobic respiration for many bacteria and archaea. In plants, this enzyme plays a crucial role in nitrogen assimilation by reducing nitrate to ammonium (NH4+), which can then be incorporated into organic compounds. Nitrate reductases require various cofactors, such as molybdenum, heme, and/or FAD, for their activity. There are three main types of nitrate reductases: membrane-bound (which use menaquinol as an electron donor), cytoplasmic (which use NADH or NADPH as an electron donor), and assimilatory (which also use NADH or NADPH as an electron donor).

Dimethylnitrosamine is a chemical compound with the formula (CH3)2NNO. It is a potent carcinogen, and is classified as a Class 1 carcinogen by the International Agency for Research on Cancer (IARC). It is known to cause cancer in various organs, including the liver, kidney, and lungs.

Dimethylnitrosamine is formed when nitrogen oxides react with secondary amines under conditions that are commonly encountered in industrial processes or in certain food preservation methods. It can also be found as a contaminant in some foods and cosmetics.

Exposure to dimethylnitrosamine can occur through inhalation, ingestion, or skin contact. The toxic effects of this compound are due to its ability to form DNA adducts, which can lead to mutations and cancer. It is important to minimize exposure to this compound and to take appropriate safety measures when working with it.

Pernicious anemia is a specific type of vitamin B12 deficiency anemia that is caused by a lack of intrinsic factor, a protein made in the stomach that is needed to absorb vitamin B12. The absence of intrinsic factor leads to poor absorption of vitamin B12 from food and results in its deficiency.

Vitamin B12 is essential for the production of healthy red blood cells, which carry oxygen throughout the body. Without enough vitamin B12, the body cannot produce enough red blood cells, leading to anemia. Pernicious anemia typically develops slowly over several years and can cause symptoms such as fatigue, weakness, pale skin, shortness of breath, and a decreased appetite.

Pernicious anemia is an autoimmune disorder, which means that the body's immune system mistakenly attacks healthy cells in the stomach lining, leading to a loss of intrinsic factor production. It is more common in older adults, particularly those over 60 years old, and can also be associated with other autoimmune disorders such as type 1 diabetes, Hashimoto's thyroiditis, and Addison's disease.

Treatment for pernicious anemia typically involves vitamin B12 replacement therapy, either through oral supplements or injections of the vitamin. In some cases, dietary changes may also be recommended to ensure adequate intake of vitamin B12-rich foods such as meat, fish, poultry, and dairy products.

Nitrite reductases are a group of enzymes that catalyze the reduction of nitrite (NO2-) to nitric oxide (NO). This reaction is an important part of the nitrogen cycle, particularly in denitrification and dissimilatory nitrate reduction to ammonium (DNRA) processes. Nitrite reductases can be classified into two main types based on their metal co-factors: copper-containing nitrite reductases (CuNiRs) and cytochrome cd1 nitrite reductases. CuNiRs are typically found in bacteria and fungi, while cytochrome cd1 nitrite reductases are primarily found in bacteria. These enzymes play a crucial role in the global nitrogen cycle and have potential implications for environmental and medical research.

Ascorbic acid is the chemical name for Vitamin C. It is a water-soluble vitamin that is essential for human health. Ascorbic acid is required for the synthesis of collagen, a protein that plays a role in the structure of bones, tendons, ligaments, and blood vessels. It also functions as an antioxidant, helping to protect cells from damage caused by free radicals.

Ascorbic acid cannot be produced by the human body and must be obtained through diet or supplementation. Good food sources of vitamin C include citrus fruits, strawberries, bell peppers, broccoli, and spinach.

In the medical field, ascorbic acid is used to treat or prevent vitamin C deficiency and related conditions, such as scurvy. It may also be used in the treatment of various other health conditions, including common cold, cancer, and cardiovascular disease, although its effectiveness for these uses is still a matter of scientific debate.

I'm sorry for any confusion, but "Formates" is not a recognized term in medical terminology. It is possible that you may be referring to "formic acid" or "formate," which are terms used in chemistry and biochemistry. Formic acid is a colorless, pungent, and corrosive liquid with the chemical formula HCOOH. Its salts are called formates.

Formate is the anion (negatively charged ion) of formic acid, with the chemical formula HCOO-. Formate can be found in various biological systems and is involved in several metabolic processes. If you could provide more context or clarify your question, I would be happy to help further.

Nitrate reductase is an enzyme that catalyzes the reduction of nitrate (NO3-) to nitrite (NO2-). It is widely distributed in nature and plays a crucial role in the nitrogen cycle, particularly in the process of nitrate assimilation by plants, fungi, and some bacteria.

In plants, nitrate reductase is primarily located in the cytoplasm and chloroplasts of plant cells. It requires reduced forms of nicotinamide adenine dinucleotide phosphate (NADPH) or flavin adenine dinucleotide (FADH2) as electron donors to facilitate the reduction of nitrate to nitrite.

The reaction catalyzed by nitrate reductase can be summarized as follows:
NO3- + NAD(P)H + H+ -> NO2- + NAD(P)+ + H2O

It is worth noting that there are different types of nitrate reductases, each with distinct properties and functions. For example, some nitrate reductases require molybdenum cofactor as a prosthetic group for their catalytic activity, while others do not. Additionally, some nitrate reductases are membrane-bound, while others are soluble enzymes.

Overall, nitrate reductase is an essential enzyme in the global nitrogen cycle and has significant implications for agriculture, environmental science, and microbiology.

Glutathione disulfide (GSSG) is the oxidized form of glutathione (GSH), which is a tripeptide composed of three amino acids: cysteine, glutamic acid, and glycine. It plays a crucial role in maintaining cellular redox homeostasis by scavenging free radicals and reactive oxygen species (ROS) in the body.

Glutathione exists in two forms - reduced (GSH) and oxidized (GSSG). In the reduced form, glutathione has a sulfhydryl group (-SH), which can donate an electron to neutralize free radicals and ROS. When glutathione donates an electron, it becomes oxidized and forms glutathione disulfide (GSSG).

Glutathione disulfide is a dimer of two glutathione molecules linked by a disulfide bond (-S-S-) between the sulfur atoms of their cysteine residues. The body can recycle GSSG back to its reduced form (GSH) through the action of an enzyme called glutathione reductase, which requires NADPH as a reducing agent.

Maintaining a proper balance between GSH and GSSG is essential for cellular health, as it helps regulate various physiological processes such as DNA synthesis, gene expression, immune function, and apoptosis (programmed cell death). An imbalance in glutathione homeostasis can lead to oxidative stress, inflammation, and the development of various diseases.

Nitric oxide (NO) donors are pharmacological agents that release nitric oxide in the body when they are metabolized. Nitric oxide is a molecule that plays an important role as a signaling messenger in the cardiovascular, nervous, and immune systems. It helps regulate blood flow, relax smooth muscle, inhibit platelet aggregation, and modulate inflammatory responses.

NO donors can be used medically to treat various conditions, such as hypertension, angina, heart failure, and pulmonary hypertension, by promoting vasodilation and improving blood flow. Some examples of NO donors include nitroglycerin, isosorbide dinitrate, sodium nitroprusside, and molsidomine. These drugs work by releasing nitric oxide slowly over time, which then interacts with the enzyme soluble guanylate cyclase to produce cyclic guanosine monophosphate (cGMP), leading to relaxation of smooth muscle and vasodilation.

It is important to note that NO donors can have side effects, such as headache, dizziness, and hypotension, due to their vasodilatory effects. Therefore, they should be used under the guidance of a healthcare professional.

Carcinogens are agents (substances or mixtures of substances) that can cause cancer. They may be naturally occurring or man-made. Carcinogens can increase the risk of cancer by altering cellular DNA, disrupting cellular function, or promoting cell growth. Examples of carcinogens include certain chemicals found in tobacco smoke, asbestos, UV radiation from the sun, and some viruses.

It's important to note that not all exposures to carcinogens will result in cancer, and the risk typically depends on factors such as the level and duration of exposure, individual genetic susceptibility, and lifestyle choices. The International Agency for Research on Cancer (IARC) classifies carcinogens into different groups based on the strength of evidence linking them to cancer:

Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans
Group 3: Not classifiable as to its carcinogenicity to humans
Group 4: Probably not carcinogenic to humans

This information is based on medical research and may be subject to change as new studies become available. Always consult a healthcare professional for medical advice.

Glutathione is a tripeptide composed of three amino acids: cysteine, glutamic acid, and glycine. It is a vital antioxidant that plays an essential role in maintaining cellular health and function. Glutathione helps protect cells from oxidative stress by neutralizing free radicals, which are unstable molecules that can damage cells and contribute to aging and diseases such as cancer, heart disease, and dementia. It also supports the immune system, detoxifies harmful substances, and regulates various cellular processes, including DNA synthesis and repair.

Glutathione is found in every cell of the body, with particularly high concentrations in the liver, lungs, and eyes. The body can produce its own glutathione, but levels may decline with age, illness, or exposure to toxins. As such, maintaining optimal glutathione levels through diet, supplementation, or other means is essential for overall health and well-being.

Nitrogen is not typically referred to as a medical term, but it is an element that is crucial to medicine and human life.

In a medical context, nitrogen is often mentioned in relation to gas analysis, respiratory therapy, or medical gases. Nitrogen (N) is a colorless, odorless, and nonreactive gas that makes up about 78% of the Earth's atmosphere. It is an essential element for various biological processes, such as the growth and maintenance of organisms, because it is a key component of amino acids, nucleic acids, and other organic compounds.

In some medical applications, nitrogen is used to displace oxygen in a mixture to create a controlled environment with reduced oxygen levels (hypoxic conditions) for therapeutic purposes, such as in certain types of hyperbaric chambers. Additionally, nitrogen gas is sometimes used in cryotherapy, where extremely low temperatures are applied to tissues to reduce pain, swelling, and inflammation.

However, it's important to note that breathing pure nitrogen can be dangerous, as it can lead to unconsciousness and even death due to lack of oxygen (asphyxiation) within minutes.

Cysteine is a semi-essential amino acid, which means that it can be produced by the human body under normal circumstances, but may need to be obtained from external sources in certain conditions such as illness or stress. Its chemical formula is HO2CCH(NH2)CH2SH, and it contains a sulfhydryl group (-SH), which allows it to act as a powerful antioxidant and participate in various cellular processes.

Cysteine plays important roles in protein structure and function, detoxification, and the synthesis of other molecules such as glutathione, taurine, and coenzyme A. It is also involved in wound healing, immune response, and the maintenance of healthy skin, hair, and nails.

Cysteine can be found in a variety of foods, including meat, poultry, fish, dairy products, eggs, legumes, nuts, seeds, and some grains. It is also available as a dietary supplement and can be used in the treatment of various medical conditions such as liver disease, bronchitis, and heavy metal toxicity. However, excessive intake of cysteine may have adverse effects on health, including gastrointestinal disturbances, nausea, vomiting, and headaches.

Anaerobiosis is a state in which an organism or a portion of an organism is able to live and grow in the absence of molecular oxygen (O2). In biological contexts, "anaerobe" refers to any organism that does not require oxygen for growth, and "aerobe" refers to an organism that does require oxygen for growth.

There are two types of anaerobes: obligate anaerobes, which cannot tolerate the presence of oxygen and will die if exposed to it; and facultative anaerobes, which can grow with or without oxygen but prefer to grow in its absence. Some organisms are able to switch between aerobic and anaerobic metabolism depending on the availability of oxygen, a process known as "facultative anaerobiosis."

Anaerobic respiration is a type of metabolic process that occurs in the absence of molecular oxygen. In this process, organisms use alternative electron acceptors other than oxygen to generate energy through the transfer of electrons during cellular respiration. Examples of alternative electron acceptors include nitrate, sulfate, and carbon dioxide.

Anaerobic metabolism is less efficient than aerobic metabolism in terms of energy production, but it allows organisms to survive in environments where oxygen is not available or is toxic. Anaerobic bacteria are important decomposers in many ecosystems, breaking down organic matter and releasing nutrients back into the environment. In the human body, anaerobic bacteria can cause infections and other health problems if they proliferate in areas with low oxygen levels, such as the mouth, intestines, or deep tissue wounds.

Oxidation-Reduction (redox) reactions are a type of chemical reaction involving a transfer of electrons between two species. The substance that loses electrons in the reaction is oxidized, and the substance that gains electrons is reduced. Oxidation and reduction always occur together in a redox reaction, hence the term "oxidation-reduction."

In biological systems, redox reactions play a crucial role in many cellular processes, including energy production, metabolism, and signaling. The transfer of electrons in these reactions is often facilitated by specialized molecules called electron carriers, such as nicotinamide adenine dinucleotide (NAD+/NADH) and flavin adenine dinucleotide (FAD/FADH2).

The oxidation state of an element in a compound is a measure of the number of electrons that have been gained or lost relative to its neutral state. In redox reactions, the oxidation state of one or more elements changes as they gain or lose electrons. The substance that is oxidized has a higher oxidation state, while the substance that is reduced has a lower oxidation state.

Overall, oxidation-reduction reactions are fundamental to the functioning of living organisms and are involved in many important biological processes.

Aerobiosis is the process of living, growing, and functioning in the presence of oxygen. It refers to the metabolic processes that require oxygen to break down nutrients and produce energy in cells. This is in contrast to anaerobiosis, which is the ability to live and grow in the absence of oxygen.

In medical terms, aerobiosis is often used to describe the growth of microorganisms, such as bacteria and fungi, that require oxygen to survive and multiply. These organisms are called aerobic organisms, and they play an important role in many biological processes, including decomposition and waste breakdown.

However, some microorganisms are unable to grow in the presence of oxygen and are instead restricted to environments where oxygen is absent or limited. These organisms are called anaerobic organisms, and their growth and metabolism are referred to as anaerobiosis.

Indicators and reagents are terms commonly used in the field of clinical chemistry and laboratory medicine. Here are their definitions:

1. Indicator: An indicator is a substance that changes its color or other physical properties in response to a chemical change, such as a change in pH, oxidation-reduction potential, or the presence of a particular ion or molecule. Indicators are often used in laboratory tests to monitor or signal the progress of a reaction or to indicate the end point of a titration. A familiar example is the use of phenolphthalein as a pH indicator in acid-base titrations, which turns pink in basic solutions and colorless in acidic solutions.

2. Reagent: A reagent is a substance that is added to a system (such as a sample or a reaction mixture) to bring about a chemical reaction, test for the presence or absence of a particular component, or measure the concentration of a specific analyte. Reagents are typically chemicals with well-defined and consistent properties, allowing them to be used reliably in analytical procedures. Examples of reagents include enzymes, antibodies, dyes, metal ions, and organic compounds. In laboratory settings, reagents are often prepared and standardized according to strict protocols to ensure their quality and performance in diagnostic tests and research applications.

Catalysis is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst, which remains unchanged at the end of the reaction. A catalyst lowers the activation energy required for the reaction to occur, thereby allowing the reaction to proceed more quickly and efficiently. This can be particularly important in biological systems, where enzymes act as catalysts to speed up metabolic reactions that are essential for life.

In the context of medicine, "chemistry" often refers to the field of study concerned with the properties, composition, and structure of elements and compounds, as well as their reactions with one another. It is a fundamental science that underlies much of modern medicine, including pharmacology (the study of drugs), toxicology (the study of poisons), and biochemistry (the study of the chemical processes that occur within living organisms).

In addition to its role as a basic science, chemistry is also used in medical testing and diagnosis. For example, clinical chemistry involves the analysis of bodily fluids such as blood and urine to detect and measure various substances, such as glucose, cholesterol, and electrolytes, that can provide important information about a person's health status.

Overall, chemistry plays a critical role in understanding the mechanisms of diseases, developing new treatments, and improving diagnostic tests and techniques.

Chemical phenomena refer to the changes and interactions that occur at the molecular or atomic level when chemicals are involved. These phenomena can include chemical reactions, in which one or more substances (reactants) are converted into different substances (products), as well as physical properties that change as a result of chemical interactions, such as color, state of matter, and solubility. Chemical phenomena can be studied through various scientific disciplines, including chemistry, biochemistry, and physics.

A diet, in medical terms, refers to the planned and regular consumption of food and drinks. It is a balanced selection of nutrient-rich foods that an individual eats on a daily or periodic basis to meet their energy needs and maintain good health. A well-balanced diet typically includes a variety of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.

A diet may also be prescribed for therapeutic purposes, such as in the management of certain medical conditions like diabetes, hypertension, or obesity. In these cases, a healthcare professional may recommend specific restrictions or modifications to an individual's regular diet to help manage their condition and improve their overall health.

It is important to note that a healthy and balanced diet should be tailored to an individual's age, gender, body size, activity level, and any underlying medical conditions. Consulting with a healthcare professional, such as a registered dietitian or nutritionist, can help ensure that an individual's dietary needs are being met in a safe and effective way.

High-performance liquid chromatography (HPLC) is a type of chromatography that separates and analyzes compounds based on their interactions with a stationary phase and a mobile phase under high pressure. The mobile phase, which can be a gas or liquid, carries the sample mixture through a column containing the stationary phase.

In HPLC, the mobile phase is a liquid, and it is pumped through the column at high pressures (up to several hundred atmospheres) to achieve faster separation times and better resolution than other types of liquid chromatography. The stationary phase can be a solid or a liquid supported on a solid, and it interacts differently with each component in the sample mixture, causing them to separate as they travel through the column.

HPLC is widely used in analytical chemistry, pharmaceuticals, biotechnology, and other fields to separate, identify, and quantify compounds present in complex mixtures. It can be used to analyze a wide range of substances, including drugs, hormones, vitamins, pigments, flavors, and pollutants. HPLC is also used in the preparation of pure samples for further study or use.

Oxygen is a colorless, odorless, tasteless gas that constitutes about 21% of the earth's atmosphere. It is a crucial element for human and most living organisms as it is vital for respiration. Inhaled oxygen enters the lungs and binds to hemoglobin in red blood cells, which carries it to tissues throughout the body where it is used to convert nutrients into energy and carbon dioxide, a waste product that is exhaled.

Medically, supplemental oxygen therapy may be provided to patients with conditions such as chronic obstructive pulmonary disease (COPD), pneumonia, heart failure, or other medical conditions that impair the body's ability to extract sufficient oxygen from the air. Oxygen can be administered through various devices, including nasal cannulas, face masks, and ventilators.

... is a process of converting organic compounds into nitroso derivatives, i.e., compounds containing the R-NO ... Nitrosation of Amines (Articles with short description, Short description matches Wikidata, Organic reactions). ...
ISBN 978-1-4822-9784-3.[page needed] Williams DL (2004). "Reagents effecting nitrosation". Nitrosation Reactions and the ... Mackerness CW, Leach SA, Thompson MH, Hill MJ (February 1989). "The inhibition of bacterially mediated N-nitrosation by vitamin ... Ingesting nitrite under conditions that result in endogenous nitrosation has been classified as "probably carcinogenic to ... C: relevance to the inhibition of endogenous N-nitrosation in the achlorhydric stomach". Carcinogenesis. 10 (2): 397-399. doi: ...
Chen, M. F.; MacDonald, S. F. (1974). "Nitrosation with Lithium Nitrite". Canadian Journal of Chemistry. 52 (9): 1760-1761. doi ...
Nitrosation Mannick, Joan B.; Schonhoff, Christopher M. (7 July 2009). "Review: NO Means No and Yes: Regulation of Cell ...
Kuhnle, G.G.C.; Bingham, S.A. (1 November 2007). "Dietary meat, endogenous nitrosation and colorectal cancer". Biochemical ... A principal concern about sodium nitrite is Nitrosation/nitrosylation, the formation of carcinogenic nitroso-compounds in meats ...
Kuhnle, G.G.C.; Bingham, S.A. (1 November 2007). "Dietary meat, endogenous nitrosation and colorectal cancer". Biochemical ... "Effect of White Versus Red Meat on Endogenous N-Nitrosation in the Human Colon and Further Evidence of a Dose Response". The ...
Thomas DD, Jourd'heuil D (October 2012). "S-nitrosation: current concepts and new developments". Antioxidants & Redox Signaling ... sensitive to oxidizing agents and modulated through S-nitrosation, a post-translational modification that regulates cell ...
... undergoes nitrosation to give dimethylnitrosamine, a carcinogen. Dimethylamine is not very toxic with the ...
Evidence now exists that ascorbic acid is a limiting factor in nitrosation reactions in people. Combet, E.; Paterson, S; Iijima ... The nitrosation is also partially reversible; aryl nitrosamines rearrange to give a para-nitroso aryl amine in the Fischer-Hepp ... "Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation". Gut. 56 (12): 1678-1684. doi:10.1136/ ...
Mitchell DA, Marletta MA (August 2005). "Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine". Nat. ... "Site-specific and redox-controlled S-nitrosation of thioredoxin". Proc. Natl. Acad. Sci. U.S.A. 108 (35): E600-6. doi:10.1073/ ...
... leads to nitrosation of amines, that yields nitrosamines (potential carcinogens). Nitrosation is low if amine concentration is ... In foodstuffs and in the gastro-intestinal tract, nitrosation and nitrosylation do not have the same consequences on consumer ... Nitrosation is adding a nitrosonium ion NO+ to an amine -NH2 leading to a nitrosamine. This conversion occurs at acidic pH, ... ascorbate inhibits nitrosation of amines to nitrosamine, because ascorbate reacts with NO−2 to form NO. Ascorbate and pH 5 thus ...
Osterloh J, Goldfield D (1984). "Butyl nitrite transformation in vitro, chemical nitrosation reactions, and mutagenesis". ...
Noguchi A, Kitamura T, Onaka H, Horinouchi S, Ohnishi Y (2010). "A copper-containing oxidase catalyzes C-nitrosation in ...
"ER reductive stress caused by Ero1α S-nitrosation accelerates senescence". Free Radical Biology and Medicine. 180: 165-178. doi ... "Reductive Stress in the Endoplasmic Reticulum Caused by Ero1α S-Nitrosation Accelerates Senescence". SSRN Electronic Journal. ...
Galkin A, Moncada S (December 2007). "S-nitrosation of mitochondrial complex I depends on its structural conformation". The ...
Generation of endogenous methylating agents by nitrosation in Escherichia coli. Journal of Bacteriology. 178:5105-5111. Harris ...
"Nitrosation of volatile amines at the workplace [MAK Value Documentation, 1990]". Nitrosation of volatile amines at the ... The nitrosamine N-nitroso-diethylamine has been found in cosmetics and is a possible product of DEMA nitrosation. However, this ...
Bosch, E.; Kochi, J. K. (1994). "Direct Nitrosation of Aromatic Hydrocarbons and Ethers with the Electrophilic Nitrosonium ...
Ohshima H, Friesen M, Brouet I, Bartsch H (September 1990). "Nitrotyrosine as a new marker for endogenous nitrosation and ...
Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I (February 2013). "Nornicotine nitrosation in saliva and its relation ... Nicotine in tobacco can form carcinogenic tobacco-specific nitrosamines through a nitrosation reaction. This occurs mostly in ...
"Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein". Proc. Natl. Acad. Sci. USA. 102 (3): ...
"Omeprazole, Helicobacter pylori status, and alterations in the intragastric milieu facilitating bacterial N-nitrosation". ...
"Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor". Journal of Proteomics. 138 ... "Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor". Journal of Proteomics. 138 ...
"Nornicotine Nitrosation in Saliva and Its Relation to Endogenous Synthesis of N′-Nitrosonornicotine in Humans". Nicotine & ...
Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I (February 2013). "Nornicotine nitrosation in saliva and its relation ...
Nitration, nitrosation, azo coupling, halogenation, sulfonation, formylation, hydroxymethylation, and aminomethylation have ...
Nitrosation/Nitration Pathways, Antioxidant Defense Mechanisms and Toxicological Implications". Chemical Research in Toxicology ...
NNN is produced by the nitrosation of nornicotine during the curing, aging, processing, and smoking of tobacco. Roughly half of ... From there, Nornicotine undergoes nitrosation (the conversion of organic compounds into nitroso derivatives by gaining a ...
Tao L, Murphy ME, English AM (May 2002). "S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from ...
Its synthesis starts by reacting 1-aminomorpholine with formaldehyde and hydrogen cyanide to give 2. Nitrosation gives the N- ...
Nitrosation is a process of converting organic compounds into nitroso derivatives, i.e., compounds containing the R-NO ... Nitrosation of Amines (Articles with short description, Short description matches Wikidata, Organic reactions). ...
S-Nitrosation at Cys47 and Cys101 was found to reduce the detoxification activity of GSTP1-1 by 94%. Circular dichroism ... These data elucidate the physical basis for the regulation of GSTP1-1 by S-nitrosation, and provide general insight into the ... Biophysical methods were used to elucidate the mechanism and molecular consequences of S-nitrosation of glutathione transferase ... isothermal titration calorimetry and protein engineering were used to develop a minimal mechanism for S-nitrosation of GSTP1-1 ...
S-Nitrosation of Hemoglobin and Hypoxic Pulmonary Vasoconstriction Steven Deem, MD; Steven Deem, MD ... Steven Deem, Joung-Uk Kim, B N Manjula, Erik R Swenson, A S Acharya, Mark T Gladwin; S-Nitrosation of Hemoglobin and Hypoxic ...
Berkeley Madonna Software for Nitrosation Kinetic Calculations Risk Assessment Strategy / Tools & Technology ... Berkeley Madonna model was used to apply mechanistic models to simulate NDMA formation from amine nitrosation reactions.. The ... Once again Berkeley Madonna was used to model dialkylamine and trialkylamines nitrosation reactions.. The details of the mode ... Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation [https:// ...
Morpholine nitrosation to better understand potential solvent based CO 2 capture process reactions. / Chandan, Payal A.; Remias ... Morpholine nitrosation to better understand potential solvent based CO 2 capture process reactions. In: Environmental Science ... Morpholine nitrosation to better understand potential solvent based CO 2 capture process reactions. Environmental Science and ... Chandan, P. A., Remias, J. E., Neathery, J. K., & Liu, K. (2013). Morpholine nitrosation to better understand potential solvent ...
Nitrosation * Oxidative Stress / physiology* * Reactive Nitrogen Species / metabolism * Reactive Oxygen Species / metabolism ...
Amidine nitrosation. Loeppky RN, Yu H. Loeppky RN, et al. Among authors: yu h. J Org Chem. 2004 Apr 30;69(9):3015-24. doi: ...
Secondary Amines Containing One Aromatic Nitro Group: Preparation, Nitrosation, Sustained Nitric Oxide Release, and the ... Nitric oxide -- Physiological effect; Nitrosation; Vascular smooth muscle; Biogenic amines; Atherosclerosis -- Treatment; ...
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat. Med. 19, 753-759 (2013). ...
S-nitrosation of plant GSNORs was confirmed after immunodetection and using mass spectrometry S-nitrosation of conserved Cys271 ... This study was focused on the dynamic regulation of the activity of plant GSNORs through reversible S-nitrosation and/or ... The major pathway of NO reactions in vivo represents S-nitrosation of thiols to form S-nitrosothiols. S-nitrosoglutathione ... Nitric oxide; Post-translational modifications; Redox regulation; S-nitrosoglutathione reductase; S-nitrosation ...
Factors influencing nitrosation of amines and amides were discussed in the Monograph on nitrite and include the role of ... BOYLAND E. & WALKER, S.A. (1974). Effect of thiocyanate on nitrosation of mines. Nature, 248: 601-602. BRADLEY, W.B. ET AL. ( ... WARD, F.W., COATES, M.E. & WALKER, R. (1986). Nitrate reduction, gastro-intestinal pH and N-nitrosation in gnotobiotic and ... endogenous nitrosation). According to Ruddell et al. (1978), iron deficient patients with gastric lesions and patients with ...
Mont.) Reaction kinetics of nitrosation of azo-dyes with a second- ary amino-group. It was found that the reaction velocity ... changes with the concentration Cl- and Bt~. Isobaric potentials and ther- mal effects of the nitrosation reaction were ...
the oxidation and nitrosation of thiols by nitric oxide ... Nitrosation reactions are quenched by O2, while the oxidation ... Nitrosation reactions are quenched by O-2(radical anion), while the oxidation chemistry mediated by peroxynitrite is quenched ... The results suggest that oxidation and nitrosation of thiols by superoxide and NO are determined by their relative fluxes and ... The results suggest that oxidation and nitrosation of thiols by superoxide and NO are determined by their relative fluxes and ...
Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 ...
Nitric oxide induced S-nitrosation causes base excision repair imbalance. DNA Repair (Amst). 2018 08; 68:25-33. ...
Nitrosation stress caused by diabetes can damage DNA and activate poly polymerase 1 (PARP1). PARP1 can not only promote the ...
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med. 2013;19(6):753. ...
... a N-nitrosamine is a classic example of N-nitrosation. Nitroso-nitrite derivatives are referred to as nitrosites while nitroso- ...
Identification of Mitochondrial S-nitrosothiols and Determination of the Protective Effect of Mitochondrial S-nitrosation in ...
9. Shephard, et al., Mutagenics Activity of Peptides and the Artificial Sweetener Aspartame after Nitrosation. Fd Chem Toxic ...
Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Commun ...
The use of potassium dichromate and sodium nitrite in aromatic nitrosations Vol 66, Iss 2, Page 315 ...
The use of potassium dichromate and sodium nitrite in aromatic nitrosations Vol 66, Iss 2, Page 315 ...
Shenoy, N. R. and Choughuley, A. S. Characterization of potentially mutagenic products from the nitrosation of piperine. Cancer ...
L. Tao, M.E.P. Murphy and A.M. English (2002) S-Nitrosation of Ca-loaded and Ca-free recombinant calbindin D28K from human ... L. Tao and A.M. English (2003) Mechanism of S-nitrosation of recombinant human brain calbindin D28K, Biochemistry 42, 3326-3334 ... J.-F. Roy, M.N. Chrétien, B. Woodside and A.M.English (2007) Reduction and S-nitrosation of the neuropeptide oxytocin: ... A.A. Romeo, A. Filosa, J.A. Capobianco and A.M. English (2001) Metal chelators inhibit S-nitrosation of Cysb93 in oxyhemoglobin ...
In situ nitrosation of anilines followed by reduction with ascorbic acid to form aryl radicals and thiolation with disulfides ...
... by the method of nitrosation-extraction. To 10 ml. of the sample solution containing 1∼10 mg. of DADA, 2.5 ml. of glacial ...
Nitrosation of volatile Amines at the Workplace onlinelibrary.wiley.com/doi/10.1002/3527600418.mb0b03e0001/pdf is a report ...
... an indicator of possible endogenous nitrosation), the risk for oesophageal cancer was seven times greater in those with a high ... perhaps because soya beans contain known inhibitors of nitrosation. The results suggest that intake of nitrosamines and nitrite ...

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