Neurilemmoma: A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)Klatskin's Tumor: Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457)Peripheral Nervous System Neoplasms: Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)Scleral Diseases: General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.
DISEASES - neurilemmomaThe disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.. Developed by Sune Frankild, Albert Pallejà, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.. ...
Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas - Full Text View - ClinicalTrials.govNeurilemmoma. Ependymoma. Meningioma. Neurofibromatoses. Neurofibroma. Neurofibromatosis 1. Hemangiopericytoma. ...
Otoneurosurgical treatment of tumors of the cerebellopontine angle. Apropos of a series of 93 casesNeurilemmoma / surgery. Neuroma, Acoustic / surgery. Postoperative Complications. Prognosis. From MEDLINE®/PubMed®, a database ...
An unusual case of glandular schwannoma.Neurilemmoma / pathology*. Retroperitoneal Neoplasms / pathology*. From MEDLINE®/PubMed®, a database of the U.S. National ...
Intramedullary schwannoma of the spinal cord. A case report and review of the literature.Neurilemmoma / pathology*, surgery. Schwann Cells / pathology. Spinal Cord Neoplasms / pathology*, surgery. From MEDLINE®/ ...
PPT - Disorders of oral cavity PowerPoint Presentation - ID:495764Neurofibromas and schwannomas (neurilemmoma) - on the tongue or buccal mucosa *Sipple syndrome - multiple mucosal neuromas, ...
Atlas of pathology for medical students22.214.171.124 Neurilemmoma of the acoustic nerve. Pictures. Neurofibromatosis, brain, neurinoma of the acoustic nerve, MR T1W ...
atlases.muni.cz/atlases/stud/atl_en/main cnspatol tumcns.html
Brain Cancer - MegaCNET | MegaCNETThe most common benign brain tumors are meningiomas and neural sheath tumors (neurilemmoma). ...
Enchondroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trialsneurilemmoma 10.1. IDH1 IDH2 10. testis refractory cancer 10.1. IDH1 IDH2 11. cystinosis, nephropathic 10.1. IDH1 IDH2 ...
Neurilemmomas - Biology-Online DictionaryHome » Neurilemmomas. neurilemmoma An encapsulated neoplasm in which the fundamental component is structurally identical to a syncytium of schwann cells. It is thought to arise from the neural crest. By convention the benign schwannoma is preferably known as neurilemmoma and the true or malignant schwannoma is designated simply as schwannoma. Although it is the most common malignancy of peripheral nerves, it is poorly understood. With neurofibromas, neurilemmomas make up at least 65% of all neurogenic tumours. ...
Gastric Schwannoma -The Gastrointestinall Atlas - gastrointestinalatlas.comVideo Endoscopic Sequence 1 of 15.. Upper gastrointestinal bleeding due to a Gastric Schwannoma. This is a 73 year-old female, who was referred to our unit because she had been presenting two upper tract digestive bleedings. When the endoscopy was performed an active bleeding was observed. The exact site of the bleeding was located; it looked like an ulcerated mass in the sub-mucosa and gave an impression to be a GIST. A blood vessel that was actively bleeding and pulsating was also observed. Hemostatic therapy with injections of absolute alcohol was initiated, infiltrating the ulcer.. Gastric Schwannoma: A Rare but Important Differential Diagnosis of a Gastric Submucosal Mass. Schwannomas, also known as neurinomas or neurilemmomas, are generally benign, slow-growing neoplasms originating in any nerve that has a Schwann cell sheath. These neoplasms are rare among the spindle cell mesenchymal tumors of the gastrointestinal tract, but develop most commonly in the stomach representing 0.2% of ...
Synthesis, Characterization and Application of Dumbbell-shaped Magnetic (Fe3O4 and γ-Fe2O3) Nanoparticles Against HeLa (Cancer)...Title:Synthesis, Characterization and Application of Dumbbell-shaped Magnetic (Fe3O4 and γ-Fe2O3) Nanoparticles Against HeLa (Cancer) Cells. VOLUME: 8 ISSUE: 6. Author(s):Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla-Al-Mamun, Hirotaka Manaka and Yuji Horie. Affiliation:Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan.. Keywords:Magnetic materials, dumbbell-shaped, hyperthermia, heat dissipation, cancer cells, cytotoxicity, magnetic-field. Abstract:The current study was designed to find out the cancer cell killing efficacy of as-synthesized dumbbell-shaped Fe3O4 and γ- Fe2O3 magnetic nanoparticles under AC (alternating current) magnetic-fields induction condition. Dumbbell-shaped Fe3O4 and γ-Fe2O3 magnetic nanoparticles were successfully prepared by a modified hydrothermal method. Ferrous chloride tetrahydrate was solely used as a precursor for the nanomaterials. The as-synthesized ...
Recipe for the Mr. Antoni cocktail, a variation on the Penicillin cocktail by Sam Ross » Cocktail adventures at Oh Gosh!The Mr. Antoni, a cocktail based on the Penicillin from Sam Ross that uses the very special Paradyswijn Genever in place of Scotch whisky.
Antoni Jan GoetzKlatskin tumorWater injection (oil production): Water injection or water flooding refers to the method in the oil industry where water is injected into the reservoir, usually to increase pressure and thereby stimulate production. Water injection wells can be found both on- and offshore, to increase oil recovery from an existing reservoir.
(1/627) Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis.
Inbred rodent strains with differing sensitivity to experimental tumor induction provide model systems for the detection of genes that either are responsible for cancer predisposition or modify the process of carcinogenesis. Rats of the inbred BD strains differ in their susceptibility to the induction of neural tumors by N-ethyl-N-nitrosourea (EtNU). Newborn BDIX rats that are exposed to EtNU (80 microg/g body weight; injected s.c.) develop malignant schwannomas predominantly of the trigeminal nerves with an incidence >85%, whereas BDIV rats are entirely resistant. A T:A-->A:T transversion mutation at nucleotide 2012 of the neu (erbB-2) gene on chromosome 10, presumably the initial event in EtNU-induced schwannoma development, is later followed by loss of the wild-type neu allele. Genetic crosses between BDIX and BDIV rats served: (a) to investigate the inheritance of susceptibility; (b) to obtain animals informative for the mapping of losses of heterozygosity (LOH) in tumors with polymorphic simple sequence length polymorphisms (SSLPs); and (c) to localize genes associated with schwannoma susceptibility by linkage analysis with SSLPs. Schwannoma development was strongly suppressed in F1 animals (20% incidence). All of the F1 schwannomas displayed LOH on chromosome 10, with a consensus region on the telomeric tip encompassing D10Rat3, D10Mgh16 and D10Rat2 but excluding neu. A strong bias toward losing the BDIV alleles suggests the involvement of a BDIV-specific tumor suppressor gene(s). Targeted linkage analysis with chromosome 10 SSLPs in F2 intercross and backcross animals localized schwannoma susceptibility to a region around D10Wox23, 30 cM centromeric to the tip. Ninety-four % of F1 tumors exhibited additional LOH at this region. Two distinct loci on chromosome 10 may thus be connected with susceptibility to the induction and development of schwannomas in rats exposed to EtNU. (+info)
(2/627) Schwannoma with features mimicking neuroblastoma: report of two cases with immunohistochemical and ultrastructural findings.
OBJECTIVE: A study of two cases of a rare variant of benign schwannoma showing areas mimicking neuroblastoma/peripheral primitive neuroectodermal tumour (PNET). METHODS: Sections of formalin fixed, paraffin embedded specimens were studied by tinctorial stains and immunohistochemistry, and the tissue retrieved from formalin was examined by electronmicroscopy in one case. RESULTS: The tumours were small and subcutaneous. Both showed features of benign schwannoma; one had a multinodular plexiform pattern. In addition, rosette-like structures consisting of collagenous cores surrounded by small round cells or slightly larger epithelioid cells were present. Tumour cells were positive for S100 protein, Leu7, and in one case GFAP, but were negative for neurofilament protein, synaptophysin, and MIC2. Type IV collagen surrounded individual cells. Electronmicroscopy in case 2 confirmed schwannian features (lamina, processes) and failed to show features of neuroblastoma (neuroendocrine granules). CONCLUSIONS: Benign schwannomas may contain rosette-like structures mimicking neuroblastoma/PNET. The techniques used confirmed schwannian differentiation only and eliminated neuroblastoma/PNET. These uncommon variants should be recognised by practising histopathologists to avoid erroneous diagnoses and inappropriate treatment. (+info)
(3/627) Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.
Specific mutations in some tumor suppressor genes such as p53 can act in a dominant fashion. We tested whether this mechanism may also apply for the neurofibromatosis type-2 gene (NF2) which, when mutated, leads to schwannoma development. Transgenic mice were generated that express, in Schwann cells, mutant NF2 proteins prototypic of natural mutants observed in humans. Mice expressing a NF2 protein with an interstitial deletion in the amino-terminal domain showed high prevalence of Schwann cell-derived tumors and Schwann cell hyperplasia, whereas those expressing a carboxy-terminally truncated protein were normal. Our results indicate that a subset of mutant NF2 alleles observed in patients may encode products with dominant properties when overexpressed in specific cell lineages. (+info)
(4/627) Probability of bilateral disease in people presenting with a unilateral vestibular schwannoma.
BACKGROUND: Some 4%-5% of those who develop vestibular schwannomas have neurofibromatosis type 2 (NF2). Although about 10% of these patients present initially with a unilateral vestibular schwannoma, the risk for a patient with a truly sporadic vestibular schwannoma developing contralateral disease is unknown. METHODS: A United Kingdom survey of 296 patients with NF2 was reviewed for laterality of vestibular schwannoma at presentation and the presence of other NF2 related features. The time to presentation of bilateral disease was calculated for patients presenting with a unilateral tumour. Mutation analysis of the NF2 gene was carried out on all available cases presenting initially with unilateral disease. RESULTS: Of 240 patients with NF2 with vestibular schwannomas, 45 (18%; 32 sporadic, 13 familial) had either a unilateral tumour or delay in detection between the first and contralateral tumours. Among those tested for NF2 mutations, eight of 27 and nine of 13 were identified among sporadic and familial cases respectively. Sporadic cases showed a high female to male ratio and 19 of 32 have not as yet developed a contralateral tumour (mean 4.1 years after diagnosis of the first). Thirteen of 32 sporadic patients developed a contralateral tumour (mean 6.5 years after the first tumour diagnosis, range 0-22 years) compared with 11 of 13 familial patients (mean delay 5 years, range 0-16 years). Seven of the 45 patients had neither a family history of NF2 nor evidence of related tumours at initial presentation (six before the age of 35 years). CONCLUSION: The risk of patients with sporadic unilateral vestibular schwannomata developing a contralateral tumour in the absence of family history or other features of NF2 is low, but those presenting with other neurogenic tumours in addition to vestibular schwannoma are at high risk of harbouring an NF2 mutation in at least a proportion of their somatic cells. (+info)
(5/627) Midline cerebellar cystic schwannoma : a case report.
An extremely unusual case of a cystic schwannoma in the region of the inferior vermis and posterior to the fourth ventricle in a fifteen year old boy is reported. The cystic tumour caused partial obstruction to the outflow of cerebrospinal fluid from fourth ventricle and resulted in development of supratentorial hydrocephalus. On investigations, the schwannoma simulated a Dandy-Walker cyst. The boy presented with symptoms of increased intracranial pressure. On surgery, the lesion was not arising from any cranial nerve, nor was it attached to brain parenchyma, blood vessel or to the dura. The possible histogenesis of the cystic schwannoma in a rare location is discussed. (+info)
(6/627) Association of lower cranial nerve schwannoma with spinal ependymoma in ? NF2.
A 15 year old male, who had earlier been operated for intraspinal intramedullary ependymoma, subsequently developed a right cerebello pontine (CP) angle mass. A diagnosis of right CP angle ependymoma was considered, in view of established histology of previously operated spinal lesion. Histopathological examination of the well defined extra-axial mass, which was attached with ninth cranial nerve, however revealed a schwannoma. A diagnosis of Neurofibromatosis-2 (NF2) is strongly suspected, because of well established fact, that the spinal ependymomas may have association with lower cranial nerve schwannomas in NF2. Cranial and spinal MRI screening for early diagnosis of associated, asymptomatic lesions, in suspected cases of NF2, particularly in children, is recommended. (+info)
(7/627) Ventral T-1 neurinoma removed via hemilaminectomy without costotransversectomy--case report.
A 39-year-old male presented with a spinal neurinoma originating from the T-1 anterior root and located ventral to the spinal cord. The tumor was removed by hemilaminectomy with only partial facetectomy without costotransversectomy. No stabilization was necessary, and no complications secondary to surgery occurred. Costotransversectomy is not necessary for neurinoma ventral to the spinal cord within the spinal canal at T-1 level because the transverse process protrudes more laterally and the spinal canal of the T-1 vertebra is wider than at other thoracic levels. (+info)
(8/627) Paediatric presentation of type 2 neurofibromatosis.
BACKGROUND: Neurofibromatosis type 2 (NF2) is a highly penetrant autosomal dominant condition predisposing affected individuals to schwannomas and meningiomas. The proportion of children presenting with meningioma or schwannoma who have NF2 is not well described, and neither is the mode of presentation in most children with the inherited disease. AIMS: To determine the frequency of childhood meningioma and schwannoma cases caused by NF2 and the mode of presentation. METHODS: The records of the Manchester Children's Tumour Registry from 1954 were searched for cases of meningioma and schwannoma. Paediatric presentation in a large UK series of NF2 was also studied. RESULTS: 18% (61/334) of patients with NF2 on the UK database presented in the paediatric age group (0-15 years), frequently with the symptoms of an isolated tumour. More than half had no family history to alert the clinician to their susceptibility. Three of 22 children presenting with a meningioma on the Manchester Children's Tumour Registry have gone on to develop classic features of NF2. CONCLUSIONS: Clinicians should suspect NF2 in children presenting with meningioma, schwannoma, and skin features, such as neurofibromas/schwannomas, but fewer than 6 cafe au lait patches, who thus fall short of a diagnosis of neurofibromatosis type 1. (+info)