National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.National Institute of Mental Health (U.S.): A component of the NATIONAL INSTITUTES OF HEALTH concerned with research, overall planning, promoting, and administering mental health programs and research. It was established in 1949.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.National Institute of Allergy and Infectious Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. It was established in 1948.National Institute of Neurological Disorders and Stroke: Component of the NATIONAL INSTITUTES OF HEALTH. It supports and conducts research, both basic and clinical, on the normal and diseases nervous system. It was established in 1950.National Institute on Aging (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research into the nature of the aging process and diseases associated with the later stages of life. The Institute was established in 1974.United StatesDelivery of Health Care: The concept concerned with all aspects of providing and distributing health services to a patient population.Health Surveys: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.Health Policy: Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.Health Promotion: Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.National Institute of Child Health and Human Development (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. It now conducts and supports research on all stages of human development. It was established in 1962.National Health Programs: Components of a national health care system which administer specific services, e.g., national health insurance.Health Care Reform: Innovation and improvement of the health care system by reappraisal, amendment of services, and removal of faults and abuses in providing and distributing health services to patients. It includes a re-alignment of health services and health insurance to maximum demographic elements (the unemployed, indigent, uninsured, elderly, inner cities, rural areas) with reference to coverage, hospitalization, pricing and cost containment, insurers' and employers' costs, pre-existing medical conditions, prescribed drugs, equipment, and services.Mental Health: The state wherein the person is well adjusted.Research Support as Topic: Financial support of research activities.National Institute of Diabetes and Digestive and Kidney Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research for a national program in diabetes, endocrinology, and metabolic diseases; digestive diseases and nutrition; and kidney, urologic, and hematologic diseases. It was established in 1948.Health Care Surveys: Statistical measures of utilization and other aspects of the provision of health care services including hospitalization and ambulatory care.National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.Health Services Accessibility: The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.National Institute on Drug Abuse (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Health: The state of the organism when it functions optimally without evidence of disease.National Institute of Environmental Health Sciences (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.Primary Health Care: Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community. (JAMA 1995;273(3):192)Attitude to Health: Public attitudes toward health, disease, and the medical care system.Health Planning: Planning for needed health and/or welfare services and facilities.Quality of Health Care: The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.National Heart, Lung, and Blood Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.Health Behavior: Behaviors expressed by individuals to protect, maintain or promote their health status. For example, proper diet, and appropriate exercise are activities perceived to influence health status. Life style is closely associated with health behavior and factors influencing life style are socioeconomic, educational, and cultural.World Health: The concept pertaining to the health status of inhabitants of the world.Institute of Medicine (U.S.): Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.Health Services Research: The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Environmental Health: The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.Health Services Needs and Demand: Health services required by a population or community as well as the health services that the population or community is able and willing to pay for.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Insurance, Health: Insurance providing coverage of medical, surgical, or hospital care in general or for which there is no specific heading.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)Health Services: Services for the diagnosis and treatment of disease and the maintenance of health.Health Education: Education that increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of health on a personal or community basis.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Health Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).Health Expenditures: The amounts spent by individuals, groups, nations, or private or public organizations for total health care and/or its various components. These amounts may or may not be equivalent to the actual costs (HEALTH CARE COSTS) and may or may not be shared among the patient, insurers, and/or employers.Outcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).Public Health Administration: Management of public health organizations or agencies.Oral Health: The optimal state of the mouth and normal functioning of the organs of the mouth without evidence of disease.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Health Care Rationing: Planning for the equitable allocation, apportionment, or distribution of available health resources.Great BritainNational Institute of Dental and Craniofacial Research (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It seeks to improve oral, dental and craniofacial health through research, research training, and the dissemination of health information by conducting and supporting basic and clinical research. It was established in 1948 as the National Institute of Dental Research and re-named in 1998 as the National Institute of Dental and Craniofacial Research.Health Status Disparities: Variation in rates of disease occurrence and disabilities between population groups defined by socioeconomic characteristics such as age, ethnicity, economic resources, or gender and populations identified geographically or similar measures.Patient Acceptance of Health Care: The seeking and acceptance by patients of health service.Public Health Practice: The activities and endeavors of the public health services in a community on any level.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Mental Health Services: Organized services to provide mental health care.Community Health Services: Diagnostic, therapeutic and preventive health services provided for individuals in the community.Health Priorities: Preferentially rated health-related activities or functions to be used in establishing health planning goals. This may refer specifically to PL93-641.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.Women's Health: The concept covering the physical and mental conditions of women.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Attitude of Health Personnel: Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Tissue Plasminogen Activator: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.World Health Organization: A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Delivery of Health Care, Integrated: A health care system which combines physicians, hospitals, and other medical services with a health plan to provide the complete spectrum of medical care for its customers. In a fully integrated system, the three key elements - physicians, hospital, and health plan membership - are in balance in terms of matching medical resources with the needs of purchasers and patients. (Coddington et al., Integrated Health Care: Reorganizing the Physician, Hospital and Health Plan Relationship, 1994, p7)Financing, Government: Federal, state, or local government organized methods of financial assistance.Rural Health: The status of health in rural populations.Health Care Sector: Economic sector concerned with the provision, distribution, and consumption of health care services and related products.Quality Assurance, Health Care: Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Consensus Development Conferences, NIH as Topic: Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).Urban Health: The status of health in urban populations.Child Health Services: Organized services to provide health care for children.Fibrinolytic Agents: Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.Population Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Health Literacy: Degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Infant, Newborn: An infant during the first month after birth.History, 20th Century: Time period from 1901 through 2000 of the common era.Thrombolytic Therapy: Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Community Health Planning: Planning that has the goals of improving health, improving accessibility to health services, and promoting efficiency in the provision of services and resources on a comprehensive basis for a whole community. (From Facts on File Dictionary of Health Care Management, 1988, p299)National Institute on Alcohol Abuse and Alcoholism (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the health, social, and economic consequences of this disease. NIAAA, NIMH, and NIDA were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Health Facilities: Institutions which provide medical or health-related services.Rural Health Services: Health services, public or private, in rural areas. The services include the promotion of health and the delivery of health care.Health Planning Guidelines: Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.Health Resources: Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)National Institute of General Medical Sciences (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Socioeconomic Factors: Social and economic factors that characterize the individual or group within the social structure.Technology Assessment, Biomedical: Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Health Manpower: The availability of HEALTH PERSONNEL. It includes the demand and recruitment of both professional and allied health personnel, their present and future supply and distribution, and their assignment and utilization.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Health Services Administration: The organization and administration of health services dedicated to the delivery of health care.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.State Medicine: A system of medical care regulated, controlled and financed by the government, in which the government assumes responsibility for the health needs of the population.Organizational Objectives: The purposes, missions, and goals of an individual organization or its units, established through administrative processes. It includes an organization's long-range plans and administrative philosophy.Regional Health Planning: Planning for health resources at a regional or multi-state level.Awards and PrizesReproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.National Institute of Biomedical Imaging and Bioengineering (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Its mission is to improve health by leading the development and accelerating the application of biomedical technologies, and integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. It was established in 2000.Program Evaluation: Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Quality-Adjusted Life Years: A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)Preventive Health Services: Services designed for HEALTH PROMOTION and prevention of disease.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Program Development: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development).Interviews as Topic: Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.Electronic Health Records: Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.Politics: Activities concerned with governmental policies, functions, etc.History, 21st Century: Time period from 2001 through 2100 of the common era.Financing, Organized: All organized methods of funding.Research Personnel: Those individuals engaged in research.Community Health Centers: Facilities which administer the delivery of health care services to people living in a community or neighborhood.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.United States Public Health Service: A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Interinstitutional Relations: The interactions between representatives of institutions, agencies, or organizations.Policy Making: The decision process by which individuals, groups or institutions establish policies pertaining to plans, programs or procedures.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Outcome and Process Assessment (Health Care): Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.EnglandAcute Disease: Disease having a short and relatively severe course.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Advisory Committees: Groups set up to advise governmental bodies, societies, or other institutions on policy. (Bioethics Thesaurus)Public Policy: A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions.Government Programs: Programs and activities sponsored or administered by local, state, or national governments.Rehabilitation: Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury.Maternal Health Services: Organized services to provide health care to expectant and nursing mothers.Health Benefit Plans, Employee: Health insurance plans for employees, and generally including their dependents, usually on a cost-sharing basis with the employer paying a percentage of the premium.Needs Assessment: Systematic identification of a population's needs or the assessment of individuals to determine the proper level of services needed.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Budgets: Detailed financial plans for carrying out specific activities for a certain period of time. They include proposed income and expenditures.Public Health Nursing: A nursing specialty concerned with promoting and protecting the health of populations, using knowledge from nursing, social, and public health sciences to develop local, regional, state, and national health policy and research. It is population-focused and community-oriented, aimed at health promotion and disease prevention through educational, diagnostic, and preventive programs.Multicenter Studies as Topic: Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.Health Occupations: Professions or other business activities directed to the cure and prevention of disease. For occupations of medical personnel who are not physicians but who are working in the fields of medical technology, physical therapy, etc., ALLIED HEALTH OCCUPATIONS is available.Data Collection: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.Information Dissemination: The circulation or wide dispersal of information.Ethnic Groups: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Reproductive Health: The physical condition of human reproductive systems.IndiaOdds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.Nutrition Surveys: A systematic collection of factual data pertaining to the nutritional status of a human population within a given geographic area. Data from these surveys are used in preparing NUTRITION ASSESSMENTS.National Institute of Nursing Research (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports clinical and basic research to establish a scientific basis for the care of individuals across the life span, from the management of patients during illness and recovery to the reduction of risks for disease and disability; the promotion of healthy lifestyles; the promotion of quality of life in those with chronic illness; and the care for individuals at the end of life. It was established in 1986.Demography: Statistical interpretation and description of a population with reference to distribution, composition, or structure.Federal Government: The level of governmental organization and function at the national or country-wide level.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Consumer Participation: Community or individual involvement in the decision-making process.Healthcare Disparities: Differences in access to or availability of medical facilities and services.National Academy of Sciences (U.S.): A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.Guideline Adherence: Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.Educational Status: Educational attainment or level of education of individuals.Health Plan Implementation: Those actions designed to carry out recommendations pertaining to health plans or programs.Interdisciplinary Communication: Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.Training Support: Financial support for training including both student stipends and loans and training grants to institutions.Government Regulation: Exercise of governmental authority to control conduct.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Poverty: A situation in which the level of living of an individual, family, or group is below the standard of the community. It is often related to a specific income level.State Health Plans: State plans prepared by the State Health Planning and Development Agencies which are made up from plans submitted by the Health Systems Agencies and subject to review and revision by the Statewide Health Coordinating Council.Substance-Related Disorders: Disorders related to substance abuse.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Internationality: The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)Family Health: The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.Community Mental Health Services: Diagnostic, therapeutic and preventive mental health services provided for individuals in the community.Rural Population: The inhabitants of rural areas or of small towns classified as rural.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Centers for Disease Control and Prevention (U.S.): An agency of the UNITED STATES PUBLIC HEALTH SERVICE that conducts and supports programs for the prevention and control of disease and provides consultation and assistance to health departments and other countries.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Health Services for the Aged: Services for the diagnosis and treatment of diseases in the aged and the maintenance of health in the elderly.Societies, Medical: Societies whose membership is limited to physicians.Catchment Area (Health): A geographic area defined and served by a health program or institution.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Search of: Recruiting, Not yet recruiting, Available Studies | 'Vulvar Diseases' - List Results - ClinicalTrials.govU.S. National Institutes of Health. * U.S. Department of Health and Human Services ... IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a ... U.S. National Library of Medicine. * ... Other U.S. Federal agency. Industry. All others (individuals, ...
NIH Research Helps Explain How Antibody Treatment Led to Lasting HIV-Like Virus RemissionScientists at the National Institutes of Health have found that the presence of the protein alpha-4 beta-7 integrin on the ... Scientists at the National Institutes of Health have found that the presence of the protein alpha-4 beta-7 integrin on the ... which is approved by the U.S. Food and Drug Administration for treating ulcerative colitis and Crohn's disease. The mechanism ... said Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, who co- ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Trial of device that is not approved or cleared by the U.S. FDA]. Withheld. No Results Available. https://ClinicalTrials.gov/ ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Device: MiniHip (Corin U.K.),Device: Metafix (Corin, U.K). https://ClinicalTrials.gov/show/NCT02174965. ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly Diagnosed Breast Cancer or Colon Cancer. ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... S-1,Drug: L-OHP (130mg/m2),Drug: L-OHP (85 mg/m2),Drug: l-LV,Drug: 5-FU. https://ClinicalTrials.gov/show/NCT02280070. ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Reproductive Health Survivorship Care Plan Pilot. Recruiting. No Results Available. Breast Cancer,Hot Flashes,Vaginal Dryness, ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... CKD-828 Drug Interaction Study (S-amlodipine). Completed. No Results Available. Healthy Male Volunteers. Drug: S-amlodipine 5mg ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Measurement of Gastrointestinal (GI) and Health-related Quality of Life (HRQL) Outcomes in Liver Transplant Recipients. ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... ESD Versus EMR for Treatment of Early Barrett`s Adenocarcinoma. Completed. No Results Available. High Grade Intraepithelial ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Effects of a 9-months Treatment of SPIRIVA on Health Related Quality of Life in Patients With COPD. Completed. No Results ...
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U.S. National Institutes of Health. U.S. National Institutes of Health ... U.S. National Institutes of Health. U.S. National Institutes of Health. ... U.S. National Institutes of Health. U.S. National Institutes of Health ... Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI). Enrolling by ...
NIOSHTIC-2 Publications Search - 20000503 - Health Hazard Evaluation Report HETA 98-0131-2704, U.https://cdc.gov/niosh/nioshtic-2/20000503.html
Hypersensitivity pneumonitis: Number of deaths by state, U.S. residents age 15 and over, 2001-20102014-811 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... Mortality multiple cause-of-death data from National Center for Health Statistics, National Vital Statistics System. ... U.S. totals represent all of the deaths reported in a given year, including those states with less than 10 reported deaths. ...
NORA services sector: Number and percent of deaths with selected work-related respiratory condition, U.S. residents age 15 and...2008-250 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... NORA services sector: Number and percent of deaths with selected work-related respiratory condition, U.S. residents age 15 and ... NORA - National Occupational Research Agenda. * data for malignant mesothelioma are for 1999 only. ...
Chronic obstructive pulmonary disease: Proportionate mortality ratio (PMR) adjusted for age, sex, and race by usual occupation,...2008-730 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... Mortality multiple cause-of-death data from National Center for Health Statistics, National Vital Statistics System. ... U.S. residents age 15 and over, selected states, 1999. ... The National Institute for Occupational Safety and Health ( ...
NORA services sector and unspecified and other pneumoconioses: Most frequently recorded industries and occupations on death...2008-615 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... U.S. residents age 15 and over, selected states and years, 1990-1999. ... NORA - National Occupational Research Agenda CIC - Census Industry Code COC - Census Occupation Code n.e.c. - not elsewhere ...
Silicosis: Most frequently recorded occupations on death certificate, U.S. residents age 15 and over, selected states and years...2008-177 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... Mortality multiple cause-of-death data from National Center for Health Statistics, National Vital Statistics System. ... Silicosis: Most frequently recorded occupations on death certificate, U.S. residents age 15 and over, selected states and years ...
Asbestosis: Years of potential life lost to age 65 and to life expectancy by race and sex, U.S. residents age 15 and over, 2005...2017-907 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for ... Content source: National Institute for Occupational Safety and Health (NIOSH) * Page maintained by: Respiratory Health Division ... Mortality multiple cause-of-death data from National Center for Health Statistics, National Vital Statistics System. ... Asbestosis: Years of potential life lost to age 65 and to life expectancy by race and sex, U.S. residents age 15 and over, 2005 ...
Our Partners | Center for Health, Work & Environment | University of Colorado DenverU.S. Department of Energy. *National Institutes of Health. *University of Colorado Health and Welfare Trust. ... Western States Division of the National Institute for Occupational Safety and Health ... We work with local, national, and international stakeholders to advance worker health, safety, and well-being. Thank you to our ... Colorado School of Public Health*. Center for Health, Work, & Environment*. Pages*. Partners ...
Advisory Committee on Construction Safety and Health (ACCSH) | Meeting Minutes/Transcripts - October 20, 2004 - Transcripts |...Advisory Committee on Construction Safety and Health (ACCSH) , Meeting Minutes/Transcripts - October 20, 2004 - Transcripts ... CHERYL F. ESTILL, M.S., P.E.. Industrial Hygiene Supervisor, Industry Wide Survey. Branch, DSHEFSCDC. National Institute for ... BRODERICK: On July 22nd down in Orlando, Florida, the Department of Labor, OSHA, NIOSH, the U.S. Hispanic Chamber of Commerce, ... Director, Safety & Health. Laborers' Health and Safety Fund of North America. MR. WILLIAM C. RHOTEN. Director, Safety & Health ...
Patent encumbrance of large automotive NiMH batteriesRadiation dose reconstruction: Radiation dose reconstruction refers to the process of estimating radiation doses that were received by individuals or populations in the past as a result of particular exposure situations of concern.A Review of the Dose Reconstruction Program of the Defense Threat Reduction Agency.Toronto Western Research Institute: The Toronto Western Research Institute (TWRI) is a non-profit academic medical research institute located in Canada’s largest city, Toronto. The TWRI is one the principal research institutes of the University Health Network of academic teaching hospitals associated with the University of Toronto; the TWRI is also one of the largest research institutes in Canada focussing on human neurological disease from both a basic science and clinical research perspective.Self-rated health: Self-rated health (also called Self-reported health, Self-assessed health, or perceived health) refers to both a single question such as “in general, would you say that you health is excellent, very good, good, fair, or poor?” and a survey questionnaire in which participants assess different dimensions of their own health.Public Health Act: Public Health Act is a stock short title used in the United Kingdom for legislation relating to public health.Bioinformatics Resource Centers: The Bioinformatics Resource Centers (BRCs) are a group of five Internet-based research centers established in 2004 and funded by NIAID (the National Institute of Allergy and Infectious Diseases.) Overview, Bioinformatics Resource Centers, National Institute of Allergy and Infectious Diseases (NIAID), January 10, 2008.List of Parliamentary constituencies in Kent: The ceremonial county of Kent,Global Health Delivery ProjectHealth policy: Health policy can be defined as the "decisions, plans, and actions that are undertaken to achieve specific health care goals within a society."World Health Organization.Lifestyle management programme: A lifestyle management programme (also referred to as a health promotion programme, health behaviour change programme, lifestyle improvement programme or wellness programme) is an intervention designed to promote positive lifestyle and behaviour change and is widely used in the field of health promotion.Jennifer Lippincott-SchwartzRock 'n' Roll (Status Quo song)Cancer Trials Support Unit: Cancer Trials Support Unit is a service of the National Cancer Institute (NCI) that provides clinicians across the United States and Canada access to cancer treatment trials. The Trials include nearly all Phase III treatment trials in breast, gastrointestinal, genitourinary, lung cancers, as well as adult leukemia.Eric J. Nestler: Eric J. Nestler, M.Halfdan T. MahlerNational Heart, Lung, and Blood Institute: right|220px|borderBehavior: Behavior or behaviour (see spelling differences) is the range of actions and [made by individuals, organism]s, [[systems, or artificial entities in conjunction with themselves or their environment, which includes the other systems or organisms around as well as the (inanimate) physical environment. It is the response of the system or organism to various stimuli or inputs, whether [or external], [[conscious or subconscious, overt or covert, and voluntary or involuntary.Andrew Dickson WhiteList of kanji by stroke count: This Kanji index method groups together the kanji that are written with the same number of strokes. Currently, there are 2,186 individual kanji listed.Great Lakes Environmental Research Laboratory: right|300px|thumb|Great Lakes Environmental Research Laboratory logo.Systematic Protein Investigative Research EnvironmentContraceptive mandate (United States): A contraceptive mandate is a state or federal regulation or law that requires health insurers, or employers that provide their employees with health insurance, to cover some contraceptive costs in their health insurance plans. In 1978, the U.School health education: School Health Education see also: Health Promotion is the process of transferring health knowledge during a student's school years (K-12). Its uses are in general classified as Public Health Education and School Health Education.WHO collaborating centres in occupational health: The WHO collaborating centres in occupational health constitute a network of institutions put in place by the World Health Organization to extend availability of occupational health coverage in both developed and undeveloped countries.Network of WHO Collaborating Centres in occupational health.Behavior change (public health): Behavior change is a central objective in public health interventions,WHO 2002: World Health Report 2002 - Reducing Risks, Promoting Healthy Life Accessed Feb 2015 http://www.who.National Cancer Research Institute: The National Cancer Research Institute (NCRI) is a UK-wide partnership between cancer research funders, which promotes collaboration in cancer research. Its member organizations work together to maximize the value and benefit of cancer research for the benefit of patients and the public.AIDS Research Alliance: AIDS Research Alliance of America (ARAA) is a national community-based 501(c)3 non-profit medical research institution that seeks to develop a cure for HIV/AIDS, medical strategies to prevent new HIV infections and better treatments for people living with HIV/AIDS. Since 1989, ARAA has conducted over 150 clinical and pre-clinical studies, ranging from alternative therapies that employ a complementary approach to HIV care to the first in-human HIV vaccine trial.National Collaborating Centre for Mental Health: The National Collaborating Centre for Mental Health (NCCMH) is one of several centres of the National Institute for Health and Care Excellence (NICE) tasked with developing guidance on the appropriate treatment and care of people with specific conditions within the National Health Service (NHS) in England and Wales. It was established in 2001.Comprehensive Rural Health Project: The Comprehensive Rural Health Project (CRHP) is a non profit, non-governmental organization located in Jamkhed, Ahmednagar District in the state of Maharashtra, India. The organization works with rural communities to provide community-based primary healthcare and improve the general standard of living through a variety of community-led development programs, including Women's Self-Help Groups, Farmers' Clubs, Adolescent Programs and Sanitation and Watershed Development Programs.Aging (scheduling): In Operating systems, Aging is a scheduling technique used to avoid starvation. Fixed priority scheduling is a scheduling discipline, in which tasks queued for utilizing a system resource are assigned a priority each.Companies OfficeWomen's Health Initiative: The Women's Health Initiative (WHI) was initiated by the U.S.Thrombolysis: Thrombolysis is the breakdown (lysis) of blood clots by pharmacological means, and commonly called clot busting. It works by stimulating secondary fibrinolysis by plasmin through infusion of analogs of tissue plasminogen activator (tPA), the protein that normally activates plasmin.European Immunization Week: European Immunization Week (EIW) is an annual regional initiative, coordinated by the World Health Organization Regional Office for Europe (WHO/Europe), to promote immunization against vaccine-preventable diseases. EIW activities are carried out by participating WHO/Europe member states.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingIncremental cost-effectiveness ratio: The incremental cost-effectiveness ratio (ICER) is a statistic used in cost-effectiveness analysis to summarise the cost-effectiveness of a health care intervention. It is defined by the difference in cost between two possible interventions, divided by the difference in their effect.Penumbra (medicine): In pathology and anatomy the penumbra is the area surrounding an ischemic event such thrombotic or embolic stroke. Immediately following the event, blood flow and therefore oxygen transport is reduced locally, leading to hypoxia of the cells near the location of the original insult.Closed-ended question: A closed-ended question is a question format that limits respondents with a list of answer choices from which they must choose to answer the question.Dillman D.Age adjustment: In epidemiology and demography, age adjustment, also called age standardization, is a technique used to allow populations to be compared when the age profiles of the populations are quite different.Antithrombotic: An antithrombotic agent is a drug that reduces the formation of blood clots (thrombi).http://cancerweb.Proportional reporting ratio: The proportional reporting ratio (PRR) is a statistic that is used to summarize the extent to which a particular adverse event is reported for individuals taking a specific drug, compared to the frequency at which the same adverse event is reported for patients taking some other drug (or who are taking any drug in a specified class of drugs). The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded.The Flash ChroniclesThrombolytic drug: Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. They limit the damage caused by the blockage or occlusion of a blood vessel.Healthy community design: Healthy community design is planning and designing communities that make it easier for people to live healthy lives. Healthy community design offers important benefits:College student alcoholism: The rates of college students binge drinking in the United States have fluctuated for the past years. As high as 40% of college students could now be considered alcoholics as defined by the next edition psychiatry's diagnostic manual but many would have only a mild problem which is intentionally for early treatment.Society for Education Action and Research in Community Health: Searching}}Resource leak: In computer science, a resource leak is a particular type of resource consumption by a computer program where the program does not release resources it has acquired. This condition is normally the result of a bug in a program.QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.
(1/1076) Report of a National Institutes of Health--Centers for Disease Control and Prevention workshop on the feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons.
A workshop was convened in 1997 by the National Institutes of Health and the Centers for Disease Control and Prevention to consider the need for and feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons. Although the benefits of weight loss in obese individuals may seem obvious, little information is available showing that intentional weight loss improves long-term health outcomes. Observational studies may be unable to provide convincing answers about the magnitude and direction of the health effects of intentional weight loss. Workshop participants agreed that a well-designed randomized clinical trial could answer several questions necessary for developing a rational clinical and public health policy for treating obesity. Such information will ultimately provide needed guidance on the risks and benefits of weight loss to health care providers and payers, as well as to millions of obese Americans. (+info)
(2/1076) A process evaluation of the National Cancer Institute's Data-based Intervention Research program: a study of organizational capacity building.
This paper reports on a qualitative process evaluation of the Data-based Intervention Research (DBIR) program, that was funded by the National Cancer Institute (NCI) and operated in 21 states and the District of Columbia. The goal of DBIR was to build a foundation within state health agencies to ensure the translation of cancer control science into practice. NCI's objective reflected the readiness of cancer control research for public health application, the paucity of cancer control activity within public health settings and the recognition that state health agencies could play a critical role in the effective transfer of research results into public health practice. The qualitative process evaluation reported in this paper is based on one case study of four DBIR programs. The present study indicates that the four state health agencies executed the DBIR program with fidelity. Also, the four states offered a balanced assessment of NCI's role in enabling the state agency operation of DBIR, providing numerous citations illustrating how NCI successfully facilitated organizational capacity as compared to fewer mentions of ways NCI was less than successful. Thus, in funding the DBIR model, NCI was successful in raising state health agency capacity to implement cancer prevention and control programming. Implications for capacity building in state health departments are discussed. (+info)
(3/1076) The impact of the National Cancer Institute's Data-based Intervention Research program on state health agencies.
To assist state health agencies adopt a new role in cancer prevention and control, the National Cancer Institute (NCI) initiated the Data-based Intervention Research (DBIR) program. The goal of DBIR was to stimulate data-driven activities and to build capacity for ongoing programs within state health agencies to ensure the translation of cancer prevention and control science into practice across the US. Each state funded under the DBIR program was required to conduct four phases of activity: identifying and analyzing relevant data, using these data to develop a state cancer control plan, and implementing and evaluating prevention and control interventions at the local level. This paper presents the results of survey of the 22 states that participated in the DBIR program. The survey is intended as a supplement to the case study also reported in this issue of Health Education Research. Results indicated that states were able to implement the DBIR model and they show the process to be useful to their cancer prevention efforts. DBIR had a major impact on how states will use data in future planning for cancer prevention and control. States had a number of recommendations for how NCI could improve its working relationships with state health agencies. (+info)
(4/1076) Long-term management of asthma: how to improve outcomes.
Improved clinical outcomes in asthma patients have been demonstrated in several clinical trials that applied the National Institutes of Health (NIH) guidelines for the long-term management of asthma. Environmental control, objective monitoring, drug therapy, and partnership in patient education are the major components of optimal management. Inhaled antiinflammatory agents are of major importance for long-term control in patients with persistent asthma. Adequate patient education is absolutely essential for excellent, cost-effective care of patients with asthma. Improved outcomes in adults with asthma have been demonstrated at clinics initiated and managed by pharmacists. Further trials are needed with large numbers of patients in managed care organizations. (+info)
(5/1076) Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin.
The administration of reference endotoxin (Escherichia coli O:113, Lot EC-5) to humans has been an important means to study inflammation in vivo; however, the supply of Lot EC-5 is depleted. A new lot of reference endotoxin (Clinical Center reference endotoxin [CCRE]), derived from the original bulk material extracted from E. coli O:113, was processed. The effects of 0-, 1-, 2-, and 4-ng/kg doses of intravenous CCRE and EC-5 were studied in 20 male subjects. CCRE resulted in dose-related increases in symptoms, temperature (P=. 016), total leukocyte count (P=.014), tumor necrosis factor-alpha (P=.004), interleukin (IL)-1 receptor antagonist (P=.004), IL-6 (P=. 005), IL-8 (P=.011), cortisol (P<.05), and C-reactive protein (P=. 04). These responses were attenuated (all P<.012) in subjects given Lot EC-5 (4 ng/kg) in comparison with those in subjects given CCRE, showing that, over several years, EC-5 had lost potency. Thus, in healthy subjects, the magnitude of exposure to CCRE results in a graded dose response of major components of innate immunity. (+info)
(6/1076) Innovation and public accountability in clinical research.
For more than 20 years, clinical researchers have expressed alarm about the decline of their field, but they have failed to achieve a consensus on policies to revitalize and sustain it. Although they have traced the plight of clinical research to profound changes in science, medicine, and public expectations, their conservative vision and preference for short-term measures inhibit effective policy formulation. These trends are the outcome of historical developments, and they seem to mandate a new approach to public policy. A potential source for more viable and socially accountable policies lies in practitioners' notion that clinical research bridges basic and applied science (by translating scientific innovations into practical measures). Exploiting that idea, however, would require a major reorientation of the field toward health services research and the institutions that are struggling to support it. (+info)
(7/1076) Annual report to the nation on the status of cancer, 1973-1996, with a special section on lung cancer and tobacco smoking.
BACKGROUND: The American Cancer Society, the National Cancer Institute (NCI), and the Centers for Disease Control and Prevention (CDC), including the National Center for Health Statistics (NCHS), provide the second annual report to the nation on progress in cancer prevention and control, with a special section on lung cancer and tobacco smoking. METHODS: Age-adjusted rates (using the 1970 U.S. standard population) were based on cancer incidence data from NCI and underlying cause of death data compiled by NCHS. The prevalence of tobacco use was derived from CDC surveys. Reported P values are two-sided. RESULTS: From 1990 through 1996, cancer incidence (-0.9% per year; P = .16) and cancer death (-0.6% per year; P = .001) rates for all sites combined decreased. Among the 10 leading cancer incidence sites, statistically significant decreases in incidence rates were seen in males for leukemia and cancers of the lung, colon/rectum, urinary bladder, and oral cavity and pharynx. Except for lung cancer, incidence rates for these cancers also declined in females. Among the 10 leading cancer mortality sites, statistically significant decreases in cancer death rates were seen for cancers of the male lung, female breast, the prostate, male pancreas, and male brain and, for both sexes, cancers of the colon/rectum and stomach. Age-specific analyses of lung cancer revealed that rates in males first declined at younger ages and then for each older age group successively over time; rates in females appeared to be in the early stages of following the same pattern, with rates decreasing for women aged 40-59 years. CONCLUSIONS: The declines in cancer incidence and death rates, particularly for lung cancer, are encouraging. However, unless recent upward trends in smoking among adolescents can be reversed, the lung cancer rates that are currently declining in the United States may rise again. (+info)
(8/1076) Promoting safe and effective genetic tests in the United States: work of the task force on genetic testing.
The Task Force on Genetic Testing was created to review genetic testing in the United States and, when necessary, to make recommendations to ensure the development of safe and effective genetic tests. A survey to explore the state of genetic testing was undertaken for the Task Force and completed in early 1995. The survey, as well as literature reports and other information collected for the Task Force, showed problems affecting safety and effectiveness, as defined by the Task Force: validity and utility of predictive tests, laboratory quality, and appropriate use by healthcare providers and consumers. On the basis of these findings, the Task Force made several recommendations to ensure safe and effective genetic testing. The Secretary of Health and Human Services followed up one recommendation by creating the Secretary's Advisory Committee on Genetic Testing. One of its functions will be to implement other recommendations of the Task Force. (+info)
- the National Institute for Occupational Safety and Health (NIOSH) received a health hazard evaluation (HHE) request from the management at U.S. Precision Lens, Inc. (USPL) in Cincinnati, Ohio. (cdc.gov)
Center for Health Statistics
- Mortality multiple cause-of-death data from National Center for Health Statistics, National Vital Statistics System. (cdc.gov)
- 2014-811 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Respiratory Health Division, Morgantown, WV. (cdc.gov)
- NORA - National Occupational Research Agenda * data for malignant mesothelioma are for 1999 only. (cdc.gov)
- Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005. (thebody.com)
- This trial is evaluating a public health intervention strategy trial which aims to reduce the incidence of HIV at a population-level. (clinicaltrials.gov)
- Health Hazard Evaluation Report HETA 98-0131-2704, U.S. Precision Lens Incorporated, Cincinnati, Ohio. (cdc.gov)
- As the majority of perinatally HIV-infected U.S. children are entering or in adolescence, the potential for HIV-related impaired BMD during the adolescent peak of bone mass acquisition is of particular concern. (clinicaltrials.gov)