Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.
A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.
Hydrolytic enzyme activity used as a histocytochemical test for the presence of esterases in tissue. Substrate used is 3-hydroxy-4'-nitro-2-naphthanilide chloroacetate (naphthol AS-D).
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
"Chemical Engineering is a branch of engineering that deals with the design, construction, and operation of plants and machinery for large-scale chemical processing of raw materials into finished or partially finished products and for the disposal or recycling of byproducts."
Tricyclic ethylene-bridged naphthalene derivatives. They are found in petroleum residues and coal tar and used as dye intermediates, in the manufacture of plastics, and in insecticides and fungicides.
A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)
A group of TETRAHYDRONAPHTHALENES containing a keto oxygen.
Azo compounds are organic compounds characterized by the presence of one or more azo groups, -N=N-, linking two aromatic rings, which can impart various colors and are used in dyes, pharmaceuticals, and chemical research.
A group of condensed ring hydrocarbons.
A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.
A chemosterilant agent that is anticipated to be a carcinogen.
An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.
Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)
3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.
Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.

A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes. (1/487)

1. The spatial and temporal distribution of intracellular H+ ions in response to activation of a proton-coupled dipeptide transporter localized at the apical pole of mouse small intestinal isolated enterocytes was investigated using intracellular carboxy-SNARF-1 fluorescence in combination with whole-cell microspectrofluorimetry or confocal microscopy. 2. In Hepes-buffered Tyrode solution, application of the dipeptide Phe-Ala (10 mM) to a single enterocyte reduced pHi locally in the apical submembranous space. After a short delay (8 s), a fall of pHi occurred more slowly at the basal pole. 3. In the presence of CO2/HCO3--buffered Tyrode solution, the apical and basal rates of acidification were not significantly different and the time delay was reduced to 1 s or less. 4. Following application of the carbonic anhydrase inhibitor acetazolamide (100 microM) in the presence of CO2/HCO3- buffer, addition of Phe-Ala once again produced a localized apical acidification that took 5 s to reach the basal pole. Basal acidification was slower than at the apical pole. 5. We conclude that acid influx due to proton-coupled dipeptide transport can lead to intracellular pH gradients and that intracellular carbonic anhydrase activity, by facilitating cytoplasmic H+ mobility, limits their magnitude and duration.  (+info)

Changes in intracellular Na+ and pH in rat heart during ischemia: role of Na+/H+ exchanger. (2/487)

The role of the Na+/H+ exchanger in rat hearts during ischemia and reperfusion was investigated by measurements of intracellular Na+ concentration ([Na+]i) and intracellular and extracellular pH. Under our standard conditions (2-Hz stimulation), 10 min of ischemia caused no significant rise in [Na+]i but an acidosis of 1.0 pH unit, suggesting that the Na+/H+ exchanger was inactive during ischemia. This was confirmed by showing that the Na+/H+ exchange inhibitor methylisobutyl amiloride (MIA) had no effect on [Na+]i or on intracellular pH during ischemia. However, there was a short-lived increase in [Na+]i of 8.2 +/- 0.6 mM on reperfusion, which was reduced by MIA, showing that the Na+/H+ exchanger became active on reperfusion. To investigate the role of metabolic changes, we measured [Na+]i during anoxia. The [Na+]i did not change during 10 min of anoxia, but there was a small, transient rise of [Na+]i on reoxygenation, which was inhibited by MIA. In addition, we show that the Na+/H+ exchanger, tested by sodium lactate exposure, was inhibited during anoxia. These results show that the Na+/H+ exchanger is inhibited during ischemia and anoxia, probably by an intracellular metabolic mechanism. The exchanger activates rapidly on reperfusion and can cause a rapid rise in [Na+]i.  (+info)

Mitotic aberrations induced by carbaryl reflect tyrosine kinase inhibition with coincident up-regulation of serine/threonine protein phosphatase activity: implications for coordination of karyokinesis and cytokinesis. (3/487)

The insecticide carbaryl and its metabolite 1-naphthol cause partial uncoupling of karyokinesis and cytokinesis in V79 Chinese hamster fibroblasts; karyokinesis is blocked in metaphase, the microtubules of the spindle depolymerize and the chromosomes and spindle remnants become displaced to the periphery of the cell. A high frequency of these disturbed cells elongate and a smaller fraction initiate a cleavage furrow. Here, we attempt to determine the potential targets for carbaryl and 1-naphthol in cytokinesis-specific signalling, led by the fact that the potential protein phosphatase inhibitor 1-naphthyl phosphate was previously identified in treated cells. We found that the typical cytological pattern induced by carbaryl and 1-naphthol could be obtained with tyrphostins, specific tyrosine kinase inhibitors, indicating that the carbaryl-induced effects could be due to tyrosine kinase inhibition. This was confirmed by tyrosine kinase assays showing that carbaryl, 1-naphthol and 2-naphthol were equally efficient at inhibiting tyrosine kinase activity as tyrphostin B44(-). As tyrosine kinases can act as regulatory factors in determining dephosphorylation rates, the activities of type-1 (PP1) and type-2A (PP2A) serine/threonine protein phosphatases were also determined. There was a clear up-regulation of the overall PP1/PP2A activities in cells treated with carbaryl, 1-naphthol or tyrphostin B44(-). This stimulation was shown to be indirect because these compounds had no effect on the activity of purified human PP1 in the test tube. 2-Naphthol, which has been found to be less efficient with regard to displacement of chromatin, did not cause up-regulation, but a significant decrease in PP1/PP2A activity. We suggest that a net decrease in tyrosine kinase activity in combination with a net increase in PP1/PP2A activity is a precondition for cell elongation and cytokinesis in mammalian cells and that the corresponding enzymes are targets in the network of activities serving to coordinate karyokinesis and cytokinesis.  (+info)

Purification and characterization of a secreted laccase of Gaeumannomyces graminis var. tritici. (4/487)

We purified a secreted fungal laccase from filtrates of Gaeumannomyces graminis var. tritici cultures induced with copper and xylidine. The active protein had an apparent molecular mass of 190 kDa and yielded subunits with molecular masses of 60 kDa when denatured and deglycosylated. This laccase had a pI of 5.6 and an optimal pH of 4.5 with 2,6-dimethoxyphenol as its substrate. Like other, previously purified laccases, this one contained several copper atoms in each subunit, as determined by inductively coupled plasma spectroscopy. The active enzyme catalyzed the oxidation of 2, 6-dimethoxyphenol (Km = 2.6 x 10(-5) +/- 7 x 10(-6) M), catechol (Km = 2.5 x 10(-4) +/- 1 x 10(-5) M), pyrogallol (Km = 3.1 x 10(-4) +/- 4 x 10(-5) M), and guaiacol (Km = 5.1 x 10(-4) +/- 2 x 10(-5) M). In addition, the laccase catalyzed the polymerization of 1, 8-dihydroxynaphthalene, a natural fungal melanin precursor, into a high-molecular-weight melanin and catalyzed the oxidation, or decolorization, of the dye poly B-411, a lignin-like polymer. These findings indicate that this laccase may be involved in melanin polymerization in this phytopathogen's hyphae and/or in lignin depolymerization in its infected plant host.  (+info)

Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. (5/487)

Brain homeostasis depends on the composition of both brain interstitial fluid and CSF. Whereas the former is largely controlled by the blood-brain barrier, the latter is regulated by a highly specialized blood-CSF interface, the choroid plexus epithelium, which acts either by controlling the influx of blood-borne compounds, or by clearing deleterious molecules and metabolites from CSF. To investigate mechanisms of brain protection at the choroid plexus, the blood-CSF barrier was reconstituted in vitro by culturing epithelial cells isolated from newborn rat choroid plexuses of either the fourth or the lateral ventricle. The cells grown in primary culture on semipermeable membranes established a pure polarized monolayer displaying structural and functional barrier features, (tight junctions, high electric resistance, low permeability to paracellular markers) and maintaining tissue-specific markers (transthyretin) and specific transporters for micronutriments (amino acids, nucleosides). In particular, the high enzymatic drug metabolism capacity of choroid plexus was preserved in the in vitro blood-CSF interface. Using this model, we demonstrated that choroid plexuses can act as an absolute blood-CSF barrier toward 1-naphthol, a cytotoxic, lipophilic model compound, by a coupled metabolism-efflux mechanism. This compound was metabolized in situ via uridine diphosphate glururonosyltransferase-catalyzed conjugation, and the cellular efflux of the glucurono-conjugate was mediated by a transporter predominantly located at the basolateral, i.e., blood-facing membrane. The transport process was temperature-dependent, probenecid-sensitive, and recognized other glucuronides. Efflux of 1-naphthol metabolite was inhibited by intracellular glutathione S-conjugates. This metabolism-polarized efflux process adds a new facet to the understanding of the protective functions of choroid plexuses.  (+info)

Sulfating-activity and stability of cDNA-expressed allozymes of human phenol sulfotransferase, ST1A3*1 ((213)Arg) and ST1A3*2 ((213)His), both of which exist in Japanese as well as Caucasians. (6/487)

We recently found single amino acid substitutions ((213)Arg/His and (223)Met/Val) in polymorphic human phenol-sulfating phenol sulfotransferase (SULT: cDNAs encoding ST1A3, P PST or HAST1/2) among Caucasians and African-Americans. In a Japanese population (n = 143), allele frequencies of (213)Arg and (213)His were 83.2 and 16. 8%, respectively, but the (223)Val allele was not found. (213)His homozygosity was reportedly associated with both very low (>7-fold) sulfating activities of p-nitrophenol (at 4 microM) and low thermostability in platelets. Sulfating-activity determinations using recombinant (213)Arg- and (213)His-forms (ST1A3*1 and ST1A3*2, respectively) did not, however, reveal appreciable deficiency in [(35)S]3'-phosphoadenosine 5'-phosphosulfate (PAPS)-dependent sulfation of p-nitrophenol (4 microM) by ST1A3*2 (7.5 vs. 10.2 nmol/min/nmol SULT for ST1A3). Kinetic parameters for p-nitrophenol for p-nitrophenol sulfation supported the slight decrease in sulfating activities at 4 microM (K(m), 0.82 vs. 1.75 microM; V(max), 13.2 vs. 13.1 nmol/min/nmol SULT, respectively, for ST1A3*1 and *2). p-Nitrophenyl sulfate-dependent 2-naphthol sulfation by ST1A3*2 was 69% of that by ST1A3*1 (p<0.05). However, ST1A3*2 was remarkably unstable at 45 and 37 degrees C as compared to ST1A3*1. The lower p-nitrophenol sulfating activity of ST1A3*2 may explain the lower platelet p-nitrophenol sulfation in ST1A3*2 homozygotes. Protein instability and ST1A3 gene regulation may be both involved in the polymorphism of p-nitrophenol sulfation in human tissues.  (+info)

Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. (7/487)

Invasion of skin by schistosome cercariae is facilitated by a serine protease secreted from the acetabular cells of cercariae in response to skin lipid. Specific inhibitors of the protease, when applied to human skin in formulations designed to retain the inhibitor on and in the upper stratum corneum layers, block cercarial invasion of human skin. Both peptide-based, irreversible inhibitors and non-peptide, reversible inhibitors block cercarial invasion when applied in a propylene glycol:isopropyl alcohol (3:1) formulation in vitro. Arrest of cercarial invasion could be achieved even after immersion of treated skin in water for 2 hr. Peptide-based irreversible inhibitors in the presence of three different Topicare Delivery Compounds optimized arrest of cercarial invasion. The three Topicare Delivery Compounds applied alone prevented 80-100% of cercarial invasion. With inclusion of the inhibitor, there was 97-100% inhibition in vitro. The optimal formulation with inhibitor was then applied to the tails of BALB/c mice, and the mice were exposed to 120 cercariae by tail immersion. With the carrier lotion alone, there was a 50% reduction in worm burden and a 70% reduction in egg burden. When inhibitor was included, an 80% reduction in worm burden and a 92% reduction in egg burden was observed.  (+info)

Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice. (8/487)

To understand the role of Na(+)/H(+) exchanger 1 (NHE1) in intracellular pH (pH(i)) regulation and neuronal function, we took advantage of natural knockout mice lacking NHE1, the most ubiquitously and densely expressed NHE isoform in the central nervous system (CNS). CA1 neurons from both wild-type (WT) and NHE1 mutant mice were studied by continuous monitoring of pH(i), using the fluorescent indicator carboxy-seminaphthorhodafluor-1 (SNARF-1) and confocal microscopy. In the nominal absence of CO(2)/HCO(3)(-), steady-state pH(i) was higher in WT neurons than in mutant neurons. Using the NH(4)Cl prepulse technique, we also show that H(+) flux in WT neurons was much greater than in mutant neurons. The recovery from acid load was blocked in WT neurons, but not in mutant neurons, by removal of Na(+) from the extracellular solution or by using 100 microM 3-(methylsulfonyl-4-piperidino-benzoyl)-guanidine methanesulfonate (HOE 694) in HEPES buffer. Surprisingly, in the presence of CO(2)/HCO(3)(-), the difference in H(+) flux between WT and mutant mice was even more exaggerated, with a difference of more than 250 microM/s between them at pH 6.6. H(+) flux in CO(2)/HCO(3)(-) was responsive to diisothiocyanato-stilbene-2, 2'-disulfonate (DIDS) in the WT but not in the mutant. We conclude that (a) the absence of NHE1 in the mutant neurons tended to cause lower steady-state pH(i) and, perhaps more importantly, markedly reduced the rate of recovery from an acid load; and (b) this difference in the rate of recovery between mutant and WT neurons was surprisingly larger in the presence, rather than in the absence, of HCO(3)(-), indicating that the presence of NHE1 is essential for the regulation and/or functional expression of both HCO(3)(-)-dependent and -independent transporters in neurons.  (+info)

Naphthols are chemical compounds that consist of a naphthalene ring (a polycyclic aromatic hydrocarbon made up of two benzene rings) substituted with a hydroxyl group (-OH). They can be classified as primary or secondary naphthols, depending on whether the hydroxyl group is directly attached to the naphthalene ring (primary) or attached through a carbon atom (secondary). Naphthols are important intermediates in the synthesis of various chemical and pharmaceutical products. They have been used in the production of azo dyes, antioxidants, and pharmaceuticals such as analgesics and anti-inflammatory agents.

Carbaryl is a carbamate pesticide that is used to control a wide variety of insects, including fleas, ticks, and mosquitoes. It works by inhibiting the action of an enzyme called cholinesterase, which is necessary for the proper functioning of the nervous system in insects. This leads to paralysis and death of the pests. Carbaryl is also used in some veterinary products to treat parasitic infestations. It can be found in various forms, such as powders, granules, and solutions, and can be applied to plants, animals, and indoor/outdoor surfaces. However, it can be harmful to non-target organisms, including humans, if not used properly. Therefore, it is important to follow the label instructions carefully when using carbaryl products.

Naphthol AS-D esterase is an enzyme that catalyzes the hydrolysis of Naphthol AS-D esters to produce phenol and naphthoic acids. It is commonly found in various tissues, including the liver, kidney, and intestine, and is used as a marker for neutrophil activation in diagnostic tests.

In medical terms, Naphthol AS-D esterase is often referred to as a "non-specific esterase" because it can hydrolyze various types of esters, not just those containing the Naphthol AS-D group. It is also known as "alkaline phosphatase" because it has optimal activity at alkaline pH levels and contains phosphate groups in its active site.

Naphthol AS-D esterase is often used in histological staining techniques to identify and differentiate various types of cells, such as neutrophils, monocytes, and macrophages, based on their enzymatic activity. The presence and intensity of the enzyme activity can provide valuable information about the type, location, and severity of inflammation or tissue damage in various pathological conditions.

Naphthalene is not typically referred to as a medical term, but it is a chemical compound with the formula C10H8. It is a white crystalline solid that is aromatic and volatile, and it is known for its distinctive mothball smell. In a medical context, naphthalene is primarily relevant as a potential toxin or irritant.

Naphthalene can be found in some chemical products, such as mothballs and toilet deodorant blocks. Exposure to high levels of naphthalene can cause symptoms such as nausea, vomiting, diarrhea, and headaches. Long-term exposure has been linked to anemia and damage to the liver and nervous system.

In addition, naphthalene is a known environmental pollutant that can be found in air, water, and soil. It is produced by the combustion of fossil fuels and is also released from some industrial processes. Naphthalene has been shown to have toxic effects on aquatic life and may pose a risk to human health if exposure levels are high enough.

Coal tar is a thick, dark liquid that is a byproduct of coal manufacturing processes, specifically the distillation of coal at high temperatures. It is a complex mixture of hundreds of different compounds, including polycyclic aromatic hydrocarbons (PAHs), which are known to be carcinogenic.

In medical terms, coal tar has been used topically for various skin conditions such as psoriasis, eczema, and seborrheic dermatitis due to its anti-inflammatory and keratolytic properties. Coal tar can help reduce scaling, itching, and inflammation of the skin. However, its use is limited due to potential side effects such as skin irritation, increased sun sensitivity, and potential risk of cancer with long-term use. Coal tar products should be used under the guidance of a healthcare provider and according to the instructions on the label.

Creosote is a thick, dark brown or black liquid that has a strong, tarry odor and is produced when wood, coal, or other organic materials are burned or distilled. It is a complex mixture of chemicals, including polycyclic aromatic hydrocarbons (PAHs), which have been linked to an increased risk of cancer.

In the medical context, creosote is not typically used as a treatment for any condition. However, it has been used historically as a topical antiseptic and wound dressing, due to its antibacterial properties. However, its use in this way has largely been replaced by more modern and effective treatments.

It's important to note that creosote is considered a hazardous substance and can be harmful if swallowed, inhaled, or comes into contact with the skin. It can cause irritation to the eyes, skin, and respiratory tract, and prolonged exposure has been linked to an increased risk of cancer. Therefore, it should be handled with care and used only under the supervision of a medical professional.

Glucuronosyltransferase (UDP-glucuronosyltransferase) is an enzyme belonging to the family of glycosyltransferases. It plays a crucial role in the process of biotransformation and detoxification of various endogenous and exogenous substances, including drugs, hormones, and environmental toxins, in the liver and other organs.

The enzyme functions by transferring a glucuronic acid moiety from a donor molecule, uridine diphosphate glucuronic acid (UDP-GlcUA), to an acceptor molecule, which can be a variety of hydrophobic compounds. This reaction results in the formation of a more water-soluble glucuronide conjugate, facilitating the excretion of the substrate through urine or bile.

There are multiple isoforms of glucuronosyltransferase, classified into two main families: UGT1 and UGT2. These isoforms exhibit different substrate specificities and tissue distributions, allowing for a wide range of compounds to be metabolized through the glucuronidation pathway.

In summary, Glucuronosyltransferase is an essential enzyme in the detoxification process, facilitating the elimination of various substances from the body by conjugating them with a glucuronic acid moiety.

Chemical engineering is a branch of engineering that deals with the design, construction, and operation of plants and machinery for the large-scale production or processing of chemicals, fuels, foods, pharmaceuticals, and biologicals, as well as the development of new materials and technologies. It involves the application of principles of chemistry, physics, mathematics, biology, and economics to optimize chemical processes that convert raw materials into valuable products. Chemical engineers are also involved in developing and improving environmental protection methods, such as pollution control and waste management. They work in a variety of industries, including pharmaceuticals, energy, food processing, and environmental protection.

Acenaphthene is an organic compound that is classified as a polycyclic aromatic hydrocarbon (PAH). It is made up of four benzene rings arranged in a specific structure. Acenaphthene is not typically used in medical applications, but it can be found in some industrial products and may be produced as a byproduct of certain chemical reactions or processes.

In the environment, acenaphthene can be released into the air, water, and soil through various sources, including the burning of coal and oil, the exhaust from vehicles, and the incineration of waste. It is not considered to be highly toxic to humans, but long-term exposure to high levels of acenaphthene has been linked to an increased risk of cancer in laboratory animals.

There are no specific medical definitions associated with acenaphthene, as it is not a substance that is typically used in medical treatments or procedures. However, it is important for healthcare professionals and researchers to be aware of the potential presence of acenaphthene and other PAHs in the environment, as these substances can have harmful effects on human health.

Phosgene is not a medical condition, but it is an important chemical compound with significant medical implications. Medically, phosgene is most relevant as a potent chemical warfare agent and a severe pulmonary irritant. Here's the medical definition of phosgene:

Phosgene (COCl2): A highly toxic and reactive gas at room temperature with a characteristic odor reminiscent of freshly cut hay or grass. It is denser than air, allowing it to accumulate in low-lying areas. Exposure to phosgene primarily affects the respiratory system, causing symptoms ranging from mild irritation to severe pulmonary edema and potentially fatal respiratory failure.

Inhaling high concentrations of phosgene can lead to immediate choking sensations, coughing, chest pain, and difficulty breathing. Delayed symptoms may include fever, cyanosis (bluish discoloration of the skin due to insufficient oxygen), and pulmonary edema (fluid accumulation in the lungs). The onset of these severe symptoms can be rapid or take up to 48 hours after exposure.

Medical management of phosgene exposure primarily focuses on supportive care, including administering supplemental oxygen, bronchodilators, and corticosteroids to reduce inflammation. In severe cases, mechanical ventilation may be necessary to maintain adequate gas exchange in the lungs.

Tetralones are not a medical term, but rather a chemical classification. They refer to a class of organic compounds that contain a tetralone ring structure, which is a cyclohexanone fused to a benzene ring. These compounds have various applications in the pharmaceutical industry as intermediates in the synthesis of drugs. Some tetralones have been studied for their potential medicinal properties, such as anti-inflammatory and analgesic effects, but they are not themselves approved medical treatments.

Azo compounds are organic compounds characterized by the presence of one or more azo groups (-N=N-) in their molecular structure. The term "azo" is derived from the Greek word "azō," meaning "to boil" or "to sparkle," which refers to the brightly colored nature of many azo compounds.

These compounds are synthesized by the reaction between aromatic amines and nitrous acid or its derivatives, resulting in the formation of diazonium salts, which then react with another aromatic compound containing an active methylene group to form azo compounds.

Azo compounds have diverse applications across various industries, including dyes, pigments, pharmaceuticals, and agrochemicals. They are known for their vibrant colors, making them widely used as colorants in textiles, leather, paper, and food products. In addition, some azo compounds exhibit unique chemical properties, such as solubility, stability, and reactivity, which make them valuable intermediates in the synthesis of various organic compounds.

However, certain azo compounds have been found to pose health risks due to their potential carcinogenicity and mutagenicity. As a result, regulations have been imposed on their use in consumer products, particularly those intended for oral consumption or direct skin contact.

I'm sorry for any confusion, but "Pyrenes" is not a medical term. It is a term used in chemistry and materials science, referring to a type of aromatic hydrocarbon molecule that consists of two benzene rings fused together. If you have a different term or concept in mind, please provide it so I can give you an accurate definition or information.

Arylsulfotransferases (ASTs) are a group of enzymes that play a role in the detoxification of xenobiotics and endogenous compounds by catalyzing the transfer of a sulfuryl group from a donor, such as 3'-phosphoadenosine-5'-phosphosulfate (PAPS), to an acceptor aromatic molecule. This results in the formation of a sulfate ester, which can then be excreted from the body. ASTs are found in various tissues, including the liver, kidney, and intestine, and are involved in the metabolism of numerous drugs, hormones, and neurotransmitters. Defects in ASTs have been associated with certain genetic disorders, such as aromatic L-amino acid decarboxylase deficiency and disorders of steroid sulfation.

I'm sorry for any confusion, but "Hempa" is not a term commonly used in medical terminology. It's possible that there may be a typo or misunderstanding in the term you're looking for. If you're referring to "hemp," I can provide some information related to this.

Hemp is a variety of the Cannabis sativa plant species that is grown specifically for industrial purposes. It has very low concentrations of tetrahydrocannabinol (THC), the main psychoactive compound found in cannabis, making it unsuitable for use as a recreational drug. Hemp is used to produce a wide range of products, including textiles, paper, rope, biodegradable plastics, paint, insulation, biofuel, food, and animal feed.

If you meant to ask about something else or if there's more information you need regarding hemp, please let me know!

Equilenin is an estrogen compound that is found in certain plants and is also produced synthetically. It is structurally similar to the natural estrogens produced by the human body, such as estradiol and estrone. Equilenin has been used in some forms of hormone replacement therapy and in the treatment of certain medical conditions, such as breast cancer and prostate cancer. However, its use is not as common as other synthetic estrogens due to its potential side effects and risks.

Like other estrogen compounds, equilenin works by binding to estrogen receptors in the body, which are found in various tissues including the breasts, uterus, bones, and brain. This binding action can stimulate cell growth and development, as well as regulate various physiological processes such as bone density, cholesterol levels, and mood.

It is important to note that the use of estrogen therapy, including equilenin, carries certain risks, particularly for postmenopausal women. Long-term use of estrogen therapy has been associated with an increased risk of breast cancer, endometrial cancer, stroke, and blood clots. Therefore, it should only be used under the close supervision of a healthcare provider and for the shortest duration necessary to treat the underlying medical condition.

Cutaneous tuberculosis (CTB) is a rare form of tuberculosis that affects the skin. It is caused by the Mycobacterium tuberculosis complex, including M. tuberculosis, M. bovis, and M. africanum. CTB can occur as a primary infection after direct inoculation of the skin with the bacteria, or it can be secondary to a distant focus of infection such as lung or lymph node TB.

The clinical presentation of CTB is varied and can include papules, nodules, pustules, ulcers, plaques, or scaly lesions. The lesions may be painless or painful, and they can be associated with systemic symptoms such as fever, night sweats, and weight loss.

CTB can be diagnosed through a combination of clinical examination, skin biopsy, culture, and PCR testing. Treatment typically involves a prolonged course of multiple antibiotics, often for six to nine months or more. The most commonly used drugs are isoniazid, rifampin, ethambutol, and pyrazinamide. Surgical excision may be necessary in some cases.

Prevention measures include early detection and treatment of pulmonary TB, BCG vaccination, and avoiding contact with people with active TB.

Glucuronides are conjugated compounds formed in the liver by the attachment of glucuronic acid to a variety of molecules, including drugs, hormones, and environmental toxins. This process, known as glucuronidation, is catalyzed by enzymes called UDP-glucuronosyltransferases (UGTs) and increases the water solubility of these compounds, allowing them to be more easily excreted from the body through urine or bile.

Glucuronidation plays a crucial role in the detoxification and elimination of many substances, including drugs and toxins. However, in some cases, glucuronides can also be hydrolyzed back into their original forms by enzymes called β-glucuronidases, which can lead to reabsorption of the parent compound and prolong its effects or toxicity.

Overall, understanding the metabolism and disposition of glucuronides is important for predicting drug interactions, pharmacokinetics, and potential adverse effects.

Potassium iodide is an inorganic, non-radioactive salt of iodine. Medically, it is used as a thyroid blocking agent to prevent the absorption of radioactive iodine in the event of a nuclear accident or radiation exposure. It works by saturating the thyroid gland with stable iodide, which then prevents the uptake of radioactive iodine. This can help reduce the risk of thyroid cancer and other thyroid related issues that may arise from exposure to radioactive materials. Potassium iodide is also used in the treatment of iodine deficiency disorders.

Phosphoadenosine phosphosulfate (PAPS) is not exactly a medical term, but a biochemical term. However, it is often referred to in the context of medical and biological research.

PAPS is a crucial molecule in the metabolism of living organisms and serves as the primary donor of sulfate groups in the process of sulfonation, which is a type of enzymatic modification that adds a sulfate group to various substrates such as proteoglycans, hormones, neurotransmitters, and xenobiotics. This process plays an essential role in several biological processes, including detoxification, signal transduction, and cell-cell recognition.

Therefore, PAPS is a critical molecule for maintaining proper physiological functions in the body, and its dysregulation has been implicated in various diseases, such as cancer, inflammation, and neurodevelopmental disorders.

Glucuronates are not a medical term per se, but they refer to salts or esters of glucuronic acid, a organic compound that is a derivative of glucose. In the context of medical and biological sciences, glucuronidation is a common detoxification process in which glucuronic acid is conjugated to a wide variety of molecules, including drugs, hormones, and environmental toxins, to make them more water-soluble and facilitate their excretion from the body through urine or bile.

The process of glucuronidation is catalyzed by enzymes called UDP-glucuronosyltransferases (UGTs), which are found in various tissues, including the liver, intestines, and kidneys. The resulting glucuronides can be excreted directly or further metabolized before excretion.

Therefore, "glucuronates" can refer to the chemical compounds that result from this process of conjugation with glucuronic acid, as well as the therapeutic potential of enhancing or inhibiting glucuronidation for various clinical applications.

Naphthol may refer to: 1-Naphthol 2-Naphthol This set index article lists chemical compounds articles associated with the same ...
1-Naphthol has been used as a prooxidant to analyze its ability to induce hemolysis in a zebrafish G6PD (glucose-6-phosphate ... 1-Naphthol is a hydroxyl-aromatic compound. Its thermodynamic properties such as heat capacity, sublimation pressure, vapor ... The ability of biochar of orange peels in adsorbing 1-naphthol from water has been investigated.. The activation energy and the ... The decomposition of 1-naphthol in aqueous solutions on exposure to gamma radiation has been studied.. ...
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Type of paint: acrylique Colour or pattern: Naphthol Red Medium
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Naphthol blue black. From CAMEO. Revision as of 13:10, 26 July 2022 by MDerrick. (talk , contribs) (MDerrick moved page Napthol ... blue black to Naphthol blue black without leaving a redirect). (diff) ← Older revision , Latest revision (diff) , Newer ... Retrieved from "https://cameo.mfa.org/index.php?title=Naphthol_blue_black&oldid=90278" ...
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2-Naphthol-6-Sulfonic Acid Sodium Salt ► Flinn Scientific SDS Sheets ► Learn health and safety information about chemicals. ... 2-Naphthol-6-Sulfonic Acid Sodium Salt. Flinn Scientific, Inc. P.O. Box 219, Batavia, IL 60510 (800) 452-1261. Chemtrec ...
2-Naphthol; LC-APCI-QFT; MS2; CE: Ramp 20%-70% (nominal); R=30000; [M-H]-. Mass Spectrum ... RECORD_TITLE: 2-Naphthol; LC-APCI-QFT; MS2; CE: Ramp 20%-70% (nominal); R=30000; [M-H]-. DATE: 2022.08.15. AUTHORS: ACESx, ... CH$NAME: 2-Naphthol. CH$NAME: Naphthalen-2-ol. CH$COMPOUND_CLASS: Intermediate substance in pigment production; Polycyclic ... Aromatic Hydrocarbons; Naphthalenes; Naphthols. CH$FORMULA: C10H8O. CH$EXACT_MASS: 144.0575. CH$SMILES: OC=1C=CC=2C=CC=CC2C1. ...
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The quantitative estimation of certain beta-naphthol sulphonic acids singly and in presence of one another ...
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Distribution of T-lymphocytes in follicular lymphomas as revealed by acid alpha-naphthol acetate esterase. ... Distribution of T-lymphocytes in follicular lymphomas as revealed by acid alpha-naphthol acetate esterase. ...
Properties: Yellow needles or platelets, mp 103°. Insol in water. Sol in alcohol, ether, glacial acetic acid, in alkali hydroxide solns. ...
2-benzyl-1-naphthol - cas 36441-32-4, synthesis, structure, density, melting point, boiling point ... Tags: melting point of 2-benzyl-1-naphthol - 36441-32-4 , boiling point of 2-benzyl-1-naphthol - 36441-32-4 , density of 2- ... benzyl-1-naphthol - 36441-32-4 , refractive index of 2-benzyl-1-naphthol - 36441-32-4 ...
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You, "Among the multiple reactive sites available on the α-naphthol substrates, the desired reaction takes place in a rather ... For the first time, an asymmetric aminative dearomatization/Michael addition cascade was realized on α-naphthols. ... Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording ... Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence - Nature Communications ...
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  • Our firm is a renowned entity, engaged in offering high quality Beta Naphthol that is a fluorescent colorless crystalline solid. (hrameshkumar.com)
  • Offered Beta Naphthol is highly appreciated for its effectiveness, purity, longer shelf life and accurate composition. (hrameshkumar.com)
  • The main difference between alpha and beta naphthol is the position of the hydroxyl (OH) group on the naphthalene ring. (pediaa.com)
  • In beta naphthol, the hydroxyl group is attached to the carbon atom at the end of the naphthalene ring. (pediaa.com)
  • Alpha naphthol refers to the isomer where the hydroxyl group is situated next to the double bond in the ring, while beta naphthol is the isomer with the hydroxyl group at the end of the naphthalene ring. (pediaa.com)
  • It presents as a white solid and stands as an isomer of beta naphthol, differing in the placement of the hydroxyl group on the naphthalene ring. (pediaa.com)
  • Although it undergoes azo coupling to create azo dyes, these derivatives are generally considered less valuable than those derived from its isomer, beta naphthol. (pediaa.com)
  • Beta Naphthol, also known as 2-Naphthol or β-naphthol, is a crystalline solid that can appear fluorescent, colorless, or occasionally yellow. (pediaa.com)
  • Traditionally, the synthesis of beta naphthol follows a two-step procedure. (pediaa.com)
  • The resultant product is then subjected to acid neutralization to yield beta naphthol. (pediaa.com)
  • An alternate approach for beta naphthol production resembles the cumene process. (pediaa.com)
  • Both alpha naphthol and beta naphthol have the same chemical formula, C 10 H 7 OH. (pediaa.com)
  • Alpha naphthol is an organic compound with the molecular formula C 10 H 7 OH, characterized by a hydroxyl group attached to the carbon atom adjacent to the double bond in the naphthalene ring, whereas beta naphthol is a crystalline organic compound (C 10 H 7 OH) with a hydroxyl group attached to the carbon atom at the end of the naphthalene ring. (pediaa.com)
  • Distribution of T-lymphocytes in follicular lymphomas as revealed by acid alpha-naphthol acetate esterase. (bmj.com)
  • Moreover, our clients can purchase this ALPHA NAPHTHOL negotiable prices from us. (arnishlaborates.in)
  • In alpha naphthol, the hydroxyl group is attached to the carbon atom adjacent to the double bond in the naphthalene ring. (pediaa.com)
  • Alpha naphthol, or 1-naphthol , having the chemical formula C 10 H 7 OH , is a fluorescent organic compound. (pediaa.com)
  • There are two primary approaches for synthesizing alpha naphthol. (pediaa.com)
  • This amine compound can then undergo hydrolysis to yield the desired alpha naphthol product. (pediaa.com)
  • Alternatively, the second method involves the hydrogenation of naphthalene to create tetralin, followed by a dehydrogenation reaction to achieve alpha naphthol. (pediaa.com)
  • Alpha naphthol serves as a precursor for various insecticides, including carbaryl, and finds application in pharmaceuticals such as nadolol and the antidepressant sertraline. (pediaa.com)
  • Alpha naphthol acts as a metabolite of the insecticide carbaryl and naphthalene. (pediaa.com)
  • Furthermore, alpha naphthol plays a pivotal role in various chemical tests, including rapid furfural tests, Molisch's tests, Sakaguchi tests, and Voges-Proskauer tests. (pediaa.com)
  • Art Spectrum® Dry Ground Pigment Naphthol Crimson. (artspectrum.com.au)
  • Naphthol Crimson is a mid blue-red pigment developed in the early 20th century. (artspectrum.com.au)
  • This 10ml tube of naphtol red bluish is formulated with pigment(s) PR170, and has a lightfastness rating of ++ (25-100 years under museum conditions). (panchroma.gr)
  • The first one was developed in the 1880's and enjoyed early success under the name para red but it was superseded in the 20th century by superior pigments such as PR170 that were still naphthols but with vastly improved permanence. (matisse.com.au)
  • Our processed premium quality 1 naphthol has a solid white crystalline crystal and an aromatic chemical compound. (khatauvalabhdas.com)
  • When a color is more expensive, like reds tend to be, you want to be able to use just a little in a mixture and Naphthol Crimson has that strength to go a long way. (matisse.com.au)
  • Naphthol Crimson is used in many ways besides its power as a pure red in graphic arts. (matisse.com.au)
  • The synonym of Naphthols Asbo is Naphthols ASBO Dyes. (dyestuff.co.in)
  • S D International is one of the leading dyes manufacturer and exporter of high grade and superior quality of Naphthols, Fast Bases & Fast Salts in India to an industry-wide customer base. (sdinternational.com)
  • A bispecific nanobody with high sensitivity/efficiency for simultaneous determination of carbaryl and its metabolite 1-naphthol in the soil and rice samples. (bvsalud.org)
  • The simultaneous determination of carbaryl and its metabolite 1- naphthol is essential for risk assessment of pesticide exposure in agricultural and environmental samples. (bvsalud.org)
  • Herein, several bispecific nanobodies (BsNbs) with different lengths of hydrophilic linkers and junction sites were prepared and characterized for the simultaneous recognition of carbaryl and its metabolite 1- naphthol . (bvsalud.org)
  • The assay demonstrated a limit of detection of 0.8 ng/mL for carbaryl and 0.4 ng/mL for 1- naphthol in buffer system. (bvsalud.org)
  • Good recoveries from soil and rice samples were obtained, ranging from 80.0% to 112.7% ( carbaryl ) and 76.5%-110.8% (1- naphthol ), respectively. (bvsalud.org)
  • Utility of urinary 1-naphthol and 2-naphthol levels to assess environmental carbaryl and naphthalene exposure in an epidemiology study. (cdc.gov)
  • As naphthalene, but not carbaryl, is also metabolized to 2-naphthol (2N), the relationship of urinary 1N to 2N within an individual may give information about source of 1N. (cdc.gov)
  • Buy high-quality Naphthols, Fast Bases & Fast Salts from S D International - Leading manufacturer and exporter of Naphthols, Fast Bases & Fast Salts who is known for its high quality. (sdinternational.com)
  • We are manufacturer and supplier of all 1-Naphthol Impurity, impurities which is to be isolated by preparative HPLC and Lyophillized. (blogspot.com)
  • We are manufacturer and supplier of all Impurities which are acceptable to all regulatory agencies in the world, US-FDA, MHRA, MCC, WHO, Brazil, Japan.We are pharmaceutical manufacturer and supplier of all 1-Naphthol impurity which are used for ANDA filing/DMF filing. (blogspot.com)
  • 1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. (sdinternational.com)
  • 1-Naphthol is a hydroxyl-aromatic compound. (sigmaaldrich.com)
  • They developed an array of asymmetric dearomatization reactions of important aromatic compounds like indoles, pyrroles, phenols, naphthols, pyridines, oxazoles, etc . by transition-metal-catalysis or organocatalysis. (nature.com)
  • Naphthol is a class of aromatic organic compounds derived from naphthalene, featuring a hydroxyl group attached to the naphthalene ring. (pediaa.com)
  • We recently reported associations between urinary 1-naphthol (1N) levels and several intermediate measures of male reproductive health, namely sperm motility, serum testosterone levels, and sperm DNA damage. (cdc.gov)
  • Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children. (cdc.gov)
  • The molecular weight of Naphthols Asbo is 313.35 g/mol and the molecular formula is C21H15O2N1. (dyestuff.co.in)
  • This compound shares the same molecular formula with 1-naphthol, but it varies in the position of the hydroxyl group on the naphthalene ring. (pediaa.com)
  • Numerous colours are manufactured directly from the compound 1-naphthol, or -naphthol, which is produced by heating 1-naphthalenesulfonic acid with caustic alkali or by heating 1-naphthylamine with water under pressure. (khatauvalabhdas.com)
  • Just Paint on the Golden Paints website describes Naphthol Red as, "bright, opaque, fire engine red. (marygwynsart.com)
  • The activation energy and the reaction rate constant of the enzymatic polymerization of 1-naphthol using laccase have been reported. (sigmaaldrich.com)
  • Surprisingly, the reaction shows exceedingly high chemo-, regio-, and stereoselectivities," said Prof. You, "Among the multiple reactive sites available on the α -naphthol substrates, the desired reaction takes place in a rather precise manner, overriding several potential side pathways including the well-known Friedel-Crafts reaction. (nature.com)
  • Naphthol may refer to: 1-Naphthol 2-Naphthol This set index article lists chemical compounds articles associated with the same name. (wikipedia.org)
  • Finding wide usage in textile, plastic, chemical and pharmaceutical industry, these when dyeing with naphthols offer economical usage. (sdinternational.com)
  • In addition to the data part, the report also provides overview of Naphthol AS-KB market, including classification, application, manufacturing technology, industry chain analysis and latest market dynamics. (valuates.com)
  • Naphthols, Fast Bases & Fast Salts are also known as certified colours and artificial colours, can be used in a varied range of combinations to make nearly any colour conceivable for cosmetic products. (sdinternational.com)
  • The physical appearance of Naphthols Asbo is Creamy White Powder. (dyestuff.co.in)
  • Gamblin's website says Naphthol Red is a, "modern organic, warm red that closely matches Cadmium Red Medium," though Naphthol Red "makes more intense tints" and is "more transparent. (marygwynsart.com)
  • The decomposition of 1-naphthol in aqueous solutions on exposure to gamma radiation has been studied. (sigmaaldrich.com)
  • Rxn chemicals are leading manufacturer of 1-Naphthol Impurity. (blogspot.com)
  • AArbor Colorants recommends Naphthol Red for printing inks and gives it an excellent light fastness rating. (marygwynsart.com)
  • The photocatalytic activity of FeWO4 - CuS composite was evaluated forphotodegradation of naphthol green B dye under visible light. (envirobiotechjournals.com)
  • S D International offers Naphthols, Fast Bases & Fast Salts who is well known for using superior quality to meet International Industry standards. (sdinternational.com)
  • S D International is committed to customer fulfilment by delivering the best quality of Naphthols, Fast Bases & Fast Salts products at competitive market prices. (sdinternational.com)
  • The first stage, involves material getting impregnated with naphthol solution. (sdinternational.com)
  • Naphthol Red was born in a chemistry lab as a derivative of coal tar. (marygwynsart.com)
  • The Asia Pacific Naphthol AS-KB market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024. (valuates.com)
  • Gamblin also reports Naphthol Red is "excellent for high key painting. (marygwynsart.com)
  • Some sources report Naphthol Red as fading in tints. (marygwynsart.com)
  • This report is an essential reference for who looks for detailed information on Asia Pacific Naphthol AS-KB market. (valuates.com)
  • Naphthols Asbo belongs to the category of having CAS number 63451-35-4. (dyestuff.co.in)

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