Musculoskeletal System: The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.Musculoskeletal Physiological Phenomena: Processes and properties of the MUSCULOSKELETAL SYSTEM.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Musculoskeletal Development: The morphologic and physiological changes of the MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body, i.e., MUSCULOSKELETAL SYSTEM, during the prenatal and postnatal stages of development.Musculoskeletal Abnormalities: Congenital structural abnormalities and deformities of the musculoskeletal system.Musculoskeletal Pain: Discomfort stemming from muscles, LIGAMENTS, tendons, and bones.Tendons: Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Muscle Neoplasms: Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.Occupational Diseases: Diseases caused by factors involved in one's employment.Joints: Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Posture: The position or attitude of the body.Locomotion: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Physical Examination: Systematic and thorough inspection of the patient for physical signs of disease or abnormality.Ankle Joint: The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Arm: The superior part of the upper extremity between the SHOULDER and the ELBOW.Gait: Manner or style of walking.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Human Engineering: The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Cumulative Trauma Disorders: Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Musculoskeletal Physiological Processes: Biological actions and functions of the MUSCULOSKELETAL SYSTEM.Computer Terminals: Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neck Pain: Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Shoulder Pain: Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.Rheumatology: A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.Sick Leave: An absence from work permitted because of illness or the number of days per year for which an employer agrees to pay employees who are sick. (Webster's New Collegiate Dictionary, 1981)Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Upper Extremity: The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.Back Pain: Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.Workload: The total amount of work to be performed by an individual, a department, or other group of workers in a period of time.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.

*  Musculoskeletal System Introduction - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Mortality due to diseases of the musculoskeletal system

How does the Canadian mortality rate due to diseases of the musculoskeletal system compare to those of peer OECD countries? ... Are more Canadians dying of musculoskeletal diseases than in the past? ... How Canada Performs , International Rankings , Health , Mortality Due to Diseases of the Musculoskeletal System ... In the 1970s, Canada's mortality rate due to diseases of the musculoskeletal system was the 6th best, earning it a "B" grade. ...
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*  Bones, Muscles, and Joints

The musculoskeletal system supports our bodies, protects our organs from injury, and enables movement. ... This Web site provides the latest information about the treatment and prevention of arthritis and musculoskeletal and skin ... National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/. ...
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*  BrendaMueller.com: 8 Autoimmune Disorders That Affecting Multiple Organs including the Musculoskeletal System

The musculoskeletal system provides form, support, stability, and movement to the body. It is made up of the bones of the ... Many of the autoimmune disorders affect multiple organs and the musculoskeletal system. The musculoskeletal system provides ... Populations Affected by AI Disorders affecting multiple organs including the musculoskeletal system. Lupus According to the ... AI disorders affecting multiple organs including the musculoskeletal system. *Lupus affects connective tissue and can strike ...
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*  An analysis of the sources of musculoskeletal system impedance.

... the impedance of musculoskeletal systems to applied loads is known to increase. In this paper a physiologically-based, higher- ... Abstract When antagonistic muscles co-contract, the impedance of musculoskeletal systems to applied loads is known to increase ... Industrial Engineering & Management - Andrej Ivanco Presentation - Vehicle powertrain SYSTEM modeling. PPT Version , PDF ...
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*  Simulating in-vivo tibiofemoral loads with the aid of a customised lifemodeler musculoskeletal system

... M�ller JH (2013) ...
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*  Heart rate zones calculator and the musculoskeletal system | Modeonline.org

If you want to know more on muscles and musculoskeletal system use google or see how the musculoskeletal system looks like. ... Heart rate zones calculator and the musculoskeletal system. by admin // May 7, 2016. // No Comments ...
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*  Biomechanics of the Musculoskeletal System :: Mechanical Engineering :: Purdue School of Engineering and Technology, IUPUI

Biomechanics of the Musculoskeletal System. ME 40200 / 3 Cr. (3 Class) Mechanical design of organisms, with emphasis on the ... Nigg and Herzog Biomechanics of the Musculo-skeletal System, John Wiley & Sons, 1994. ... mechanics of the musculoskeletal system. Selected topics in prosthesis design and biomaterials; emphasis on the unique ...
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*  Bones, Muscles, and Joints

The musculoskeletal system supports our bodies, protects our organs from injury, and enables movement. ... The movements your muscles make are coordinated and controlled by the brain and nervous system. The involuntary muscles are ... Generally, we can't consciously control our smooth muscles; rather, they're controlled by the nervous system automatically ( ... which help break up food and move it through the digestive system. Smooth muscle is also found in the walls of blood vessels, ...
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*  musculoskeletal system Archives - Workers Comp, Car Accident, Slip and Fall Doctors

Musculoskeletal system , Lower Hudson Medical Associates spine and pain clinic announces grand opening on October 15th, located ... Tags: car accidents, dislocations, fractures, musculoskeletal pain, musculoskeletal system, pain specialist, rehabilitation, ... Tags: car accidents, chronic pain management, Lower Hudson Medical Associates, medical group, musculoskeletal system, pain ... Musculoskeletal pain is the most common reason for medical visits to the doctor. It can be as simple as a carpel tunnel from ...
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*  Musculoskeletal System - ppt download

Emergency care for Musculoskeletal system. The Skeletal System The Musculoskeletal system consists of: - Bones (skeleton) - ... Download ppt "Musculoskeletal System" * Ppt on vegetarian and non vegetarian Ppt on pin diode spice Ppt on life history of ... 1 Musculoskeletal System. Metro Community College NURS 1110 Nancy Pares, RN, MSN ... Musculoskeletal Trauma Tissue is subjected to more force than it can absorb Severity depends on: ◦ Amount of force ◦ Location ...
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*  Nourishing the Musculoskeletal System | Robin Rose Bennett

Nourishing the musculoskeletal system is as important as nourishing any other. The best way to do this is with food, herbs, and ... Nourishing the Musculoskeletal System. By Robin Bennett. Posted in Blog. On June 27, 2017 ... Artemisia vulgaris is rich in minerals that nourish the nervous system, and also the joints and connective tissue. You can ... Red clover infusion is a great source of bio-available minerals that support excellent musculoskeletal health. Nettles are rich ...
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*  Disorders of Tendons - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Osteochondrosis in Horses - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Project replicates human musculoskeletal system to advance robotics

... Home , Robotics , Project replicates human musculoskeletal ... Project replicates human musculoskeletal system to advance robotics 20th February 2017. *Surveillance robot reduces danger 27th ... First and foremost, the human musculoskeletal system is a proven solution that leads to dexterous, dynamic and robust robots. ... has been built with EOS systems for Plastic Additive Manufacturing. ...
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*  Interdigital Fibroma in Sheep - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Osteomyelitis in Small Animals - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Ankylosing Spondylosis in Cattle - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Heel Erosion in Cattle - Musculoskeletal System - Merck Veterinary Manual

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*  Radial Paralysis in Cattle - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  Slipper Foot in Cattle - Musculoskeletal System - Merck Veterinary Manual

The nervous system The neuromuscular junction The muscle The skeleton Am I Correct?. ...
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*  The Musculoskeletal System, artwork - Stock Image C020/2984 - Science Photo Library

Anatomical model showing the human muscular system. - Stock Image C020/2984 ... muscular system, musculoskeletal system, normal, skeletal muscle, voluntary muscle ... Caption: Anatomical model showing the human muscular system.. Release details: Model release not required. Property release not ...
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*  Cholangiocarcinoma - hilar | Image | Radiopaedia.org

Details of the image 'Cholangiocarcinoma - hilar' Modality: MRI (T1 arterial)
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*  Cough and Low blood platelet level and Mouth symptoms - Symptom Checker - check medical symptoms at RightDiagnosis

AND Musculoskeletal symptoms (11 matches). *AND Red blood cell symptoms (11 matches) ... Heart Electrical System. *Hernia - Pediatric. *Herniated Disk. *Hip dysplasia - Pediatric. *Hot Flashes ...
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*  Science and Development of Muscle Hypertrophy - Callisto.Ro

Neuromuscular System. Endocrine, Paracrine, and Autocrine Systems. Chapter 2. Mechanisms of Hypertrophy ...
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Human musculoskeletal system: The human musculoskeletal system (also known as the locomotor system, and previously the activity system) is an organ system that gives humans the ability to move using their muscular and skeletal systems. The musculoskeletal system provides form, support, stability, and movement to the body.Musculoskeletal abnormalityJournal of Musculoskeletal Pain: The Journal of Musculoskeletal Pain is a quarterly Peer review-peer-reviewed medical journal covering research on chronic muscle and bone pain, including fibromyalgia, myofascial pain, and other types of musculoskeletal pain. It is published by Informa Healthcare.Quadriceps tendon: In human anatomy, the quadriceps tendon, also known as the patellar tendon, allows the quadriceps femoris muscles (rectus femoris, vastus lateralis, vastus medialis, and vastus intermedius)Saladin, Kenneth S. Anatomy & Physiology: The Unity of Form and Function.Mechanochemistry: Mechanochemistry or mechanical chemistry is the coupling of mechanical and chemical phenomena on a molecular scale and includes mechanical breakage, chemical behaviour of mechanically stressed solids (e.g.Dredge ball joint: A dredge ball joint is a connection between two pipes that are used to transport a mixture of water and sand from a dredger to the discharging area.Myokine: A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.Bente Klarlund Pedersen , Thorbjörn C.Riding-like sittingWalker (BEAM): In BEAM robotics, a walker is a walking machine that has a driven mode of locomotion by intermittent ground-contacting legs. They usually possess 1 to 12 (generally, three or less) motors.Voluntary Parenthood League: The Voluntary Parenthood League (VPL) was an organization that advocated for contraception during the birth control movement in the United States. The VPL was founded in 1919 by Mary Dennett.Full-body CT scan: A full-body scan is a scan of the patient's entire body as part of the diagnosis or treatment of illnesses. If computed tomography (CAT) scan technology is used, it is known as a full-body CT scan, though many medical imaging technologies can perform full-body scans.Footballer's ankle: Footballer's Ankle is a pinching or impingement of the ligaments or tendons of the ankle between the bones, particularly the talus and tibia. This results in pain, inflammation and swelling.Cancellous bone: Cancellous bone, synonymous with trabecular bone or spongy bone, is one of two types of osseous tissue that form bones. The other osseous tissue type is cortical bone also called compact bone.Gait (human): Human gait refers to locomotion achieved through the movement of human limbs. Human gait is defined as bipedal, biphasic forward propulsion of center of gravity of the human body, in which there are alternate sinuous movements of different segments of the body with least expenditure of energy.Matrix model: == Mathematics and physics ==Human factors and ergonomics: Human factors and ergonomics (HF&E), also known as comfort design, functional design, and user-friendly systems,Ergonomics in Thesaurus.com is the practice of designing products, systems or processes to take proper account of the interaction between them and the people who use them.Maladaptation: A maladaptation () is a trait that is (or has become) more harmful than helpful, in contrast with an adaptation, which is more helpful than harmful. All organisms, from bacteria to humans, display maladaptive and adaptive traits.Aging movement control: Normal aging movement control in humans is about the changes on the muscles, motor neurons, nerves, sensory functions, gait, fatigue, visual and manual responses, in men and women as they get older but who do not have neurological, muscular (atrophy, dystrophy...) or neuromuscular disorder.Closed-ended question: A closed-ended question is a question format that limits respondents with a list of answer choices from which they must choose to answer the question.Dillman D.WorkraveMuscle contraction: Muscle contraction is the activation of tension-generating sites within muscle fibers. In physiology, muscle contraction does not mean muscle shortening because muscle tension can be produced without changes in muscle length such as holding a heavy book or a dumbbell at the same position.QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingAvijit Lahiri: Avijit Lahiri is a researcher in cardiology[http://www.journals.Cancer pain: Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response. Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures.German Center for Pediatric and Adolescent Rheumatology: == History ==Sick leave: Sick leave (or paid sick days or sick pay) is time off from work that workers can use to stay home to address their health and safety needs without losing pay. Paid sick leave is a statutory requirement in many nations around the world.WHO collaborating centres in occupational health: The WHO collaborating centres in occupational health constitute a network of institutions put in place by the World Health Organization to extend availability of occupational health coverage in both developed and undeveloped countries.Network of WHO Collaborating Centres in occupational health.Pain scale: A pain scale measures a patient's pain intensity or other features. Pain scales are based on self-report, observational (behavioral), or physiological data.

(1/250) Extended field of view sonography in musculoskeletal imaging.

The usage patterns and benefits of extended field of view sonography were analyzed prospectively in 100 consecutive musculoskeletal ultrasonographic examinations. Extended field of view sonography was used in 23 of 58 abnormal cases (10 of 41 shoulders, five of eight other joints, seven of seven extra-articular extremities, one of two interventional procedures) and two of 42 normal cases. Of 23 abnormal cases using extended field of view sonography (12 of 46 tendon tears and 11 of 12 fluid collections or masses), this modality helped in measuring abnormalities in 13, displaying abnormalities in 19, showing spatial relationships in 17, communicating findings in 13, and making diagnoses in 0. Extended field of view is a useful technique for musculoskeletal ultrasonography. The primary benefits are measuring and displaying abnormalities (most often fluid collections or masses and extra-articular extremity abnormalities).  (+info)

(2/250) The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype.

Various mutations of the hairless (hr) gene of mice result in hair loss and other integument defects. To examine the role of the hr gene in mouse development, the expression profile of hr has been determined by in situ hybridisation and correlated to the nature of genetic changes and morphological abnormalities in different mutant animals. Four variant alleles have been characterised at the molecular level. hr/hr mice produce reduced, but significant, levels of hr mRNA whereas other alleles contain mutations which would be expected to preclude the synthesis of functional product, demonstrating a correlation between allelic variation at the hr locus and phenotypic severity. hr expression was shown to be widespread and temporally regulated. It was identified in novel tissues such as cartilage, developing tooth, inner ear, retina, and colon as well as in skin and brain. Analysis of mice homozygous for the rhino allele of hairless revealed that, although no morphological defects were detectable in many tissues normally expressing hr, previously undescribed abnormalities were present in several tissues including inner ear, retina, and colon. These findings indicate that the hairless gene product plays a wider role in development than previously suspected. Dev Dyn 1999;216:113-126.  (+info)

(3/250) Damage in systemic lupus erythematosus and its association with corticosteroids.

OBJECTIVE: To evaluate the association between corticosteroid use and organ damage in patients with systemic lupus erythematosus (SLE). METHODS: The occurrence and date of organ damage, as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, were determined for 539 patients enrolled in the Hopkins Lupus Cohort Study. The risk of damage associated with the cumulative prednisone dose, high-dose prednisone (> or =60 mg/day for > or =2 months), and pulse methylprednisolone (1,000 mg intravenously for 1-3 days) was estimated using Cox proportional hazards regression analyses, controlling for age, race, and sex. Risk estimates for the cumulative prednisone dose were based on a reference dose of 36.5 gm (e.g., 10 mg of prednisone daily for 10 years [or equivalent]). RESULTS: The cumulative prednisone dose was significantly associated with the development of osteoporotic fractures (relative risk [RR] 2.5, 95% confidence interval [95% CI] 1.7, 3.7), symptomatic coronary artery disease (RR 1.7, 95% CI 1.1, 2.5), and cataracts (RR 1.9, 95% CI 1.4, 2.5). Each intravenous pulse was associated with a small increase in the risk of osteoporotic fractures (RR 1.3, 95% CI 1.0, 1.8); however, this result failed to reach statistical significance (P = 0.07). Each 2-month exposure to high-dose prednisone was associated with a 1.2-fold increase in the risk of both avascular necrosis (95% CI 1.1, 1.4) and stroke (95% CI 1.0, 1.5). CONCLUSION: SLE patients receiving long-term prednisone therapy were at significant risk of morbidity due to permanent organ damage. Additional research is required to determine the relative contributions of SLE disease activity and corticosteroids to the pathogenesis of specific types of organ damage. Furthermore, new steroid-sparing therapies are needed in order to treat disease activity and minimize cumulative and high-dose prednisone exposure.  (+info)

(4/250) Developmental expression pattern of the cdo gene.

CDO is a cell-surface protein of the immunoglobulin/fibronectin type III repeat family that positively regulates myogenic differentiation in vitro. To gain a better understanding of the role of cdo during vertebrate development, we carried out an extensive in situ hybridization study to characterize its expression pattern from postimplantation to late stages of mouse embryogenesis and in rat brain from E13 to adult. Our results show a broad pattern of cdo expression that is spatially and temporally restricted during embryogenesis. In the central nervous system (CNS), cdo expression is detected as early as E7.5 and maintained in the dorsal ventricular zones of the brain and spinal cord, becoming increasingly restricted in the adult. High levels of cdo are detected in developing sensory organs, such as the eye and ear. Outside the CNS, cdo is expressed mainly in neural crest and mesodermal derivatives, including skeletal muscle precursors. Overall, the highest levels of cdo expression are seen from E9.0 to E15.5. The temporal onset and restricted expression of cdo suggest that cdo plays a role in the determination and/or differentiation of a number of cell types during embryogenesis.  (+info)

(5/250) Incomplete lupus erythematosus: results of a multicentre study under the supervision of the EULAR Standing Committee on International Clinical Studies Including Therapeutic Trials (ESCISIT).

OBJECTIVE: Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus (SLE). The aim of this multicentre study was to describe the outcome of these so-called incomplete SLE patients. Two aspects of the outcome were studied: (i) the disease course, defined by the presence or absence of clinical symptoms; and (ii) the number of patients that eventually developed full SLE. METHODS: Outcome parameters were the ACR criteria, the SLE disease Activity Index (SLEDAI), the European Consensus Lupus Activity Measure (ECLAM) and the requirement for treatment. In 10 European rheumatology centres, patients who had been evaluated in the last 3 months of 1994 and had been diagnosed as having incomplete SLE on clinical grounds for at least 1 yr were included in the study. All 122 patients who were included in the study were evaluated annually during 3 yr of follow-up. RESULTS: Our results are confined to a patient cohort defined by disease duration of at least 1 yr, being under clinical care at the different centres in Europe. These patients showed disease activity that was related mostly to symptoms of the skin and the musculoskeletal system, and leucocytopenia. During the follow-up, low doses of prednisolone were still being prescribed in 43% of the patients. On recruitment to the study, 22 of the 122 incomplete SLE patients already fulfilled the ACR criteria for the diagnosis of SLE. In the 3 yr of follow-up only three patients developed SLE. CONCLUSIONS: A high proportion of patients in our cohort defined on clinical grounds as having incomplete SLE eventually showed disease activity defined by the SLEDAI as well as ECLAM. However, only three cases developed to SLE during the follow-up. This suggests that incomplete SLE forms a subgroup of SLE that has a good prognosis.  (+info)

(6/250) Expression and function of Ets transcription factors in mammalian development: a regulatory network.

The Ets transcription factor family is involved in a variety of mammalian developmental processes at the cellular, tissue and organ levels. They are implicated in cellular proliferation, differentiation, migration, apoptosis and cell - cell interactions. This article reviews recent studies that demonstrate the integral importance of Ets in the dosage dependent regulation of development. The expression of many Ets genes is associated with mesenchymal - epithelial interactions and changes in extracellular matrix proteins. These inductive processes contribute to tissue remodeling and integrity, particularly during embryonic development. Overlapping as well as unique patterns of Ets expression are evident in developing tissues, including development of the lymphoid and myeloid lineages, brain and central nervous system, bone and mammary gland. Integration of these data will allow the development of predictive models for the regulation of complex developmental processes.  (+info)

(7/250) Ets transcription factors and targets in osteogenesis.

Bone formation in vivo is a complex phenomenon whereby recruitment and replication of mesenchymal precursors of osteoblasts, differentiation into preosteoblasts, osteoblasts, and mature osteoblasts ultimately result in the accumulation and mineralization of the extracellular matrix. MC3T3-E1, a clonal osteoblastic cell line, was derived from mouse calvaria and undergoes an ordered and time dependent developmental sequence leading to formation of multilayered bone nodules over a 30 - 35 day period. This developmental pattern is characterized by the replication of preosteoblasts followed by growth arrest and expression of mature osteoblastic characteristics such as matrix maturation and eventual formation of multilayered nodules with a mineralized extracellular matrix. We have found that Ets1 is expressed in proliferating preosteoblastic cells whereas Ets2 is expressed by differentiating and mature osteoblasts. In addition, the expression of Ets1 can be induced in MC3T3-E1 and fetal rat calvaria cells by retinoic acid (RA) which is known to exert profound effects on skeletal growth and development, bone turnover, and induce specific cellular responses in bone cells. Thus the multiple functions of RA in bone cells are likely to be mediated in part by Ets1. Also, Ets2 transgenic mice develop multiple neurocranial, viserocranial, and cervical skeletal abnormalities. Significantly, these abnormalities are similar to the skeletal anomalies found in trisomy-16 mice and in humans with Down's syndrome, wherein the dosage of Ets2 is known to be increased. These results indicate that Ets2 has an important role in skeletal development and that Ets2 overexpression in transgenics is responsible for the genesis of the same type of skeletal abnormalities that are seen in Down's syndrome. Thus the genetic programs regulated by Ets1 and Ets2 may significantly affect the development and differentiation of osteoblasts, and in fact, Ets1 has been shown to interact with the 'quintessential' osteoblast transcription factor CbfA1. This review will examine in detail the role and possible targets of Ets1 and Ets2 in osteoblast differentiation and bone formation.  (+info)

(8/250) Preferential utilization of healthcare systems by a Malaysian rural community for the treatment of musculoskeletal injuries.

The preferential utilization of healthcare systems by a rural Malaysian community in Perlis for the treatment of musculoskeletal injuries was studied using focus group discussions. The objectives of the study were to explore the pattern of utilization of healthcare systems, the factors influencing the choice of a healthcare provider, rural residents' expectations of their healthcare provider and their views on integrating traditional and modern scientific healthcare systems. Most participants considered traditional and modern scientific healthcare systems as complementing each other. For musculoskeletal injuries, the traditional system was considered the primary choice of healthcare regardless of the participants' socioeconomic and educational levels. Key factors for preferring traditional care were the nature of treatment, the perceived shorter duration for recovery and inclusion of spiritual elements in the therapy. Barriers to seeking hospital treatment were the perceived longer duration for recovery, fear of surgery, use of metallic implants and casts that were culturally unacceptable and objections from elders. For perceived life-threatening situations, in children, pregnancy, and where injuries to internal organs were suspected, hospital treatment was preferred as the primary choice. Discussions on integrating traditional and modern scientific systems were inconclusive.  (+info)



Disease


  • IMHA has been very successful in being inclusive, transparent, and engaging with the various musculoskeletal and skin disease and oral disease stakeholders in developing their research strategy. (gc.ca)