An rpoB signature sequence provides unique resolution for the molecular typing of cyanobacteria. (1/1147)
(+info)Rapid discrimination of Legionella by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. (2/1147)
(+info)Erwinia piriflorinigrans sp. nov., a novel pathogen that causes necrosis of pear blossoms. (3/1147)
(+info)Mycoplasma mucosicanis sp. nov., isolated from the mucosa of dogs. (4/1147)
(+info)Rhizobium borbori sp. nov., aniline-degrading bacteria isolated from activated sludge. (5/1147)
(+info)The Ontario universal typing of tuberculosis (OUT-TB) surveillance program--what it means to you. (6/1147)
BACKGROUND: Tuberculosis (TB) is a serious disease that is transmitted primarily by the airborne route. Effective disease control and outbreak management requires the timely diagnosis, isolation and treatment of infected individuals with active disease; contact tracing to identify secondary cases likely to benefit from treatment of latent infection; and laboratory identification or confirmation of epidemiologically linked cases. TB genotyping enables the comparison of Mycobacterium tuberculosis complex (MTBC) strains and the identification of cases that may or may not be linked. The increased availability of molecular methods for genotyping has allowed for greater discrimination of MTBC strains and greatly enhanced understanding of TB transmission patterns. OBJECTIVE: To improve TB surveillance and control in Ontario, the Public Health Laboratories of the Ontario Agency for Health Protection and Promotion has introduced the Ontario Universal Typing of Tuberculosis (OUT-TB) Surveillance Program. METHODS: The first isolate from every new TB case will be genotyped with two rapid molecular methods: spoligotyping and mycobacterial interspersed repetitive unit-variable-number tandem repeat typing. MTBC isolates with nonunique genotypes and, thus, potentially linked to other TB cases, will also be genotyped by IS6110 restriction fragment length polymorphism analysis. CONCLUSION: By providing TB control programs using these new genotyping tools, and using traditional and new case investigation methods (eg, social network analysis), this new program will provide a clearer picture of TB in Ontario, and permit more effective use of public health resources and improve disease control. (+info)Review of detection of Brucella spp. by polymerase chain reaction. (7/1147)
Here we present a review of most of the currently used polymerase chain reaction (PCR)-based methods for identification of Brucella bacteria in biological samples. We focused in particular on methods using single-pair primers, multiplex primers, real-time PCRs, PCRs for marine Brucella, and PCRs for molecular biotyping. These methods are becoming very important tools for the identification of Brucella, at the species level and recently also at the biovar level. These techniques require minimum biological containment and can provide results in a very short time. In addition, genetic fingerprinting of isolates aid in epidemiological studies of the disease and its control. PCR-based methods are more useful and practical than conventional methods used to identify Brucella spp., and new methods for Brucella spp. identification and typing are still being developed. However, the sensitivity, specificity, and issues of quality control and quality assurance using these methods must be fully validated on clinical samples before PCR can be used in routine laboratory testing for brucellosis. (+info)Serological, bacteriological, and molecular diagnosis of brucellosis in domestic animals in Croatia. (8/1147)
AIM: To present the surveillance data on Brucella melitensis, B. suis, and B. ovis infection in cattle, sheep, goats, and swine in Croatia obtained in 2008 by serological, bacteriological, and molecular methods for diagnostics of brucellosis in domestic animals. METHODS: We serologically tested 42,785 cattle serums, 22,686 sheep and goat serums, and 28520 swine serums using the Rose Bengal test, complement fixation test, and various immunosorbent assays. We also tested 10,173 ram blood samples for B. ovis infection using the complement fixation test. Bacteriological examination was conducted on 214 samples collected from 34 serologically positive animals. Different molecular methods were employed in the identification and typing of 20 isolates from the samples. RESULTS: B. melitensis biovar (bv.) 3 was confirmed with different identification methods in 2 flocks in 2 Croatian counties and B. suis bv. 2 in 3 flocks in 3 counties. B. melitensis in cows was confirmed for the first time in Croatia. Infection with B. ovis was serologically confirmed in 202 rams in 12 counties. CONCLUSIONS: In 2008, the size of the brucellosis-affected area in Croatia and the efficiency of detection and prevention of brucellosis in sheep, goats, and swine were satisfactory. Infection with B. melitensis in cattle was confirmed for the first time and possible links for infection in humans were detected. More efficient measures for suppression and control of ovine epididymitis are required and a new strategy may be necessary for complete eradication of this disease. (+info)
Molecular Assembly of Clostridium botulinum progenitor M complex of type E | Scientific Reports
We have determined the crystal structure of M type Progenitor complex of botulinum neurotoxin E [PTC-E(M)], a heterodimer of ... The crystal structure explains the mechanism of molecular assembly of the complex and reveals several acidic clusters at the ... strongly suggests that the progenitor M complexes of all botulinum serotypes may have similar molecular arrangement, although ... Molecular characterization of type E Clostridium botulinum and comparison to other types of Clostridium botulinum. Biochim. ...
Phenotypic and molecular diversities of spinocerebellar ataxia type 2 in Japan
Dominican Republic Molecular Blood Typing, Grouping Infectious Disease
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DNA Topoisomerases: Types and Mechanisms | Molecular Biology | JoVE
Type IC is mainly found in archaea and has a similar mechanism as type IB. Most Type I topoisomerases do not require ATP to ... Types and Mechanism of action. Topoisomerases are divided into two main types. Type I Topoisomerases act on one strand of ... The mechanism of type IA topoisomerase-mediated DNA topological transformations. Molecular Cell 7, no. 2 (2001): 301-307. ... They are divided into two subtypes, Type IIA and Type IIB. These subtypes are distinguished by their structure and locations of ...
Gold nanoparticle fluorescent molecular beacon for low-resolution DQ2 gene HLA typing
... Beni, Valerio Universitat Rovira i ... Gold nanoparticles; HLA typing; Molecular beacons; Fluorescent genosensor; Coeliac disease National Category Analytical ... Improvement of the specificity of the molecular beacons was also achieved by the incorporation within their recognition ... Finally, gold nanoparticles functionalized with two molecular beacons targeting the DQA1*05* and DQB1*02* alleles allowed the ...
Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III
Glycogen storage disease type III (GSD-III) is an inborn error of glycogen metabolism caused by a deficiency of the glycogen ... Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III. * Sue-Hyun Oh , Hyung- ... "Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III" Clinical Chemistry and ... "Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III" Clinical Chemistry and ...
Plants | Free Full-Text | Molecular Characterization of Novel x-Type HMW Glutenin Subunit 1B × 6.5 in Wheat
A high level of similarity was found between the sequence encoding 1B × 6.5 and other x-type encoding alleles of this locus. ... Subunit 1B × 6.5 has a theoretical molecular weight of 88,322.83 Da, which is more mobile than 1B × 6 subunit, and isoelectric ... A novel high molecular weight glutenin subunit encoded by the Glu-1B locus was identified in the French genotype Bagou, which ... Molecular Characterization of Novel x-Type HMW Glutenin Subunit 1B × 6.5 in Wheat by Tímea Kuťka Hlozáková ...
Frontiers | Isolation, Molecular Typing, and Antibiotic Susceptibility Testing of Mycobacterium avium Subspecies hominissuis...
Mycobacterial colonies were isolated from a popliteal lymph node aspirate sample and molecular typed by SNPs typing of the ... Mycobacterial colonies were isolated from a popliteal lymph node aspirate sample and molecular typed by SNPs typing of the ... Here we describe the isolation, molecular typing, and antibiotic susceptibility testing of the causative agent of a rare case ... Results from SNPs typing of gyrB and ITS, as well as from MIRU-VNTR analysis suggested the isolation of a single strain of M. ...
Molecular Vision: Evidence of genetic heterogeneity in
Alberta Hutterites with Usher syndrome type I
Clinical examination defines three types: Usher syndrome type I (USH1) with severe to profound congenital hearing impairment, ... Evidence of genetic heterogeneity in Alberta Hutterites with Usher syndrome type I. Qi Zhou,1 Chaeli Lenger,2 Richard Smith,2 ... To date, there are five known USH1 genes: MYO7A (USH1B), cadherin-23 (CDH23; USH1D), PCDH15 (USH1F), Usher syndrome type 1C ( ... Usher syndrome type I is the most severe form of this disease. USH1 patients suffer from severe to profound prelingual and ...
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Molecular Atlas of Small Cell Lung Cancer Reveals Unusual Cell Type That Could Explain Why It's So Aggressive | Memorial Sloan...
Molecular Atlas of Small Cell Lung Cancer Reveals Unusual Cell Type That Could Explain Why Its So Aggressive Share * ... Homing in on Molecular Changes. The single cell technique also allowed the team to go further. Within the cells making up this ... We treat every type of cancer, including the most important one: yours.. With cancer, where you get treated first matters. From ... A new molecular atlas of the disease, produced by scientists at Memorial Sloan Kettering, sheds light on what makes the cancer ...
Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients...
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular ... Qin J, Li Y, Cai Z et al (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490:55-60 ... Watts T, Berti I, Sapone A et al (2005) Role of intestinal tight junction modulator zonulin in the pathogenesis of type 1 ... Larsen N et al (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5:e9085 ...
The diverse cold molecular gas contents, morphologies, and kinematics of type-2 quasars as seen by ALMA | Instituto de...
... and adjacent continuum observations of seven nearby radio-quiet type-2 quasars (QSO2s) obtained with ALMA at ∼0.2″ resolution ( ... The diverse cold molecular gas contents, morphologies, and kinematics of type-2 quasars as seen by ALMA. ... The diverse cold molecular gas contents, morphologies, and kinematics of type-2 quasars as seen by ALMA ... These outflows represent 0.2-0.7% of the QSO2s total molecular gas mass and have maximum velocities of 200-350 km s−1, radii ...
talks.cam : Prof Gabriel Waksman - Structural and molecular biology of bacterial Type IV Secretion Systems
Molecular Vision: Two novel disease-causing mutations in the CLRN1 gene in patients with Usher syndrome type 3
Usher syndrome type III can mimic other types of Usher syndrome. Ann Otol Rhinol Laryngol. 2003; 112:525-30. [PMID: 12834121] ... Two novel disease-causing mutations in the CLRN1 gene in patients with Usher syndrome type 3 Gema García-García,1 María J. ... Usher syndrome type 3 is rare except among Finns and Ashkenazi Jews. In fact, most studies show that USH3 represents less than ... Fields RR, Zhou G, Huang D, Davis JR, Möller C, Jacobson SG, Kimberling WJ, Sumegi J. Usher syndrome type III: revised genomic ...
Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. | Molecular Pharmacology
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RNA editing and the biogenesis of AMPA-type glutamate receptors | Research Institute of Molecular Pathology (IMP)
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Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation | www.ibmc.up.pt
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ALMA imaging of the cold molecular and dusty disk in the type 2 active nucleus of the Circinus galaxy | Astronomy &...
ALMA imaging of the cold molecular and dusty disk in the type 2 active nucleus of the Circinus galaxy. Konrad R. W. Tristram1, ... 12 the molecular line ratio maps for CO(6−5) to CO(3−2), HCO+(4−3) to CO(3−2) and HCN(4−3) to HCO+(4−3). For the CO(6−5) to CO( ... which is seen as a sign for these molecular lines being better probes of the rotating dense molecular gas in the torus than CO( ... Our molecular lines trace the (cold) dense mid-plane of the disk. A much higher velocity dispersion, σ , 50 km s−1, is measured ...
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Molecular cloning, refined physical map and heterogeneity of methylation sites of papilloma virus type 1a DNA - Research -...
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Academic Unit: Cellular, Molecular, Structural, and Genetic Studies / Subject: Molecular biology / Type: Theses / Degree Level:...
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BiologyHuman MoleculaCharacterizationEpidemiologyMycobacteriumGeneticGenesDiagnosticsGeneticsGenome2022EpidemiologicGenomicsHeterogeneityAssaysBacterialEscherichiaKinematicsPharmacologyTumorsIsolatesReagentsHumansBiochemicalPrognosisSubunitSummarizesChromosomeCold molecularGlobal molecularObesity and type 2 diabetStrainsClades2016TumorIsolateSerotypesIsolationDiabetes mellitusSequenceInhibitAutosomal recessiveMechanismMechanismsCharacteristicsInfectious diseaseAnalysisUsherPlateletsStudyLipidSubjectsDeficiencyVariantsLineagePatientsMarkersNucleiMethodsSearchCell type-specificMild
Biology1
- Avalanche® Transfection Reagent Series: Built on their expert knowledge & experience, powered by their vision & passion, EZ Biosystems™ has been dedicated to the research and development of next-generation transfection reagents by applying their expertise in combinatorial chemistry, molecular biology, and cell biology. (cambio.co.uk)
Human Molecula1
- Human Molecular Genetics. (wikipedia.org)
Characterization3
- Targeted therapies have a minimal role in PC partly because of the molecular characterization is not well understood. (carislifesciences.com)
- An experimental toolbox for characterization of mammalian collagen type I in biological specimens Nat Protoc. (moleculardepot.com)
- Lee, Min Kyung, "Characterization of cell type-specific molecular heterogeneity in cancer using multi-omic approaches" (2023). (dartmouth.edu)
Epidemiology3
- In order to obtain data on isolated M. bovis strains and assist in the control and eradication program for BTB, a cross sectional descriptive molecular epidemiology study in the Brazilian Midwest was conducted. (fiocruz.br)
- Molecular epidemiology of dengue virus type 3 in Venezuela. (ox.ac.uk)
- The molecular epidemiology of Candida albicans infections in animals has been rarely studied. (springer.com)
Mycobacterium1
- Molecular typing of Mycobacterium spp. (who.int)
Genetic8
- More recently, typing to investigate the genetic structure and possible epide- decaying wood from certain species of trees has been proposed miologic relationships between clinical and environmental iso- as environmental habitat for this variety (6). (cdc.gov)
- We present a fluorescent genosensor, exploiting molecular-beacon-functionalized gold nanoparticles, for the identification of human leukocyte antigen (HLA) DQ2 gene, a key genetic factor in coeliac disease. (diva-portal.org)
- To identify the genetic defect in a Hutterite population from northern Alberta with Usher syndrome type I. (molvis.org)
- The finding of a MYO7A mutation in two related Hutterite families from northern Alberta provides evidence of genetic heterogeneity in Hutterites affected by Usher syndrome type I. (molvis.org)
- Here, we describe two Hutterite families from northern Alberta with Usher syndrome type I who did not carry a mutation in exon 10 of PCDH15 but did carry a mutation in exon 3 of the myosin VIIA ( MYO7 A) gene, providing evidence of genetic heterogeneity in Alberta Hutterites with Usher syndrome type I. (molvis.org)
- Genetic typing of the initial DEN-3 isolate from Panama at CDC indicated the virus belongs to the Sri Lanka/India genotype, which caused major dengue hemorrhagic fever (DHF) epidemics in Sri Lanka and India during 1989-1992. (cdc.gov)
- In this study, multilocus sequence typing was used to characterise the genetic diversity and population structure of 24 avian origin C. albicans isolates collected from different birds with candidiasis and compared to human isolates. (springer.com)
- To address those questions, we applied functional genomics approaches to study genetic variants pertinent to obesity and type 2 diabetes-related traits. (lu.se)
Genes11
- Cases exhibited elevated expression of type 1 interferon-stimulated genes (ISGs) in monocytes, reduction of naïve CD4 + T cells that correlated with monocyte ISG expression, and expansion of repertoire-restricted cytotoxic GZMH + CD8 + T cells. (nih.gov)
- Mycobacterial colonies were isolated from a popliteal lymph node aspirate sample and molecular typed by SNPs typing of the genes gyrB and rpsA , the 3′ region of the hsp65 gene and the internal transcribed spacer (ITS), and MIRU-VNTR analysis. (frontiersin.org)
- SNP typing takes advantage of nucleotide changes in specific single-copy genes-i.e., gyrA, gyrB, groEL1, sodA, rpsA , and hsp65 -( 10 - 12 ) or chromosomal loci-i.e., 16S−23S rDNA internal transcribed spacer (ITS)-( 13 ) to use them as biomarkers for subspecies differentiation. (frontiersin.org)
- In this study, we characterised the genes encoding type 3 fimbriae from CAUTI strains of Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca , Citrobacter koseri and Citrobacter freundii . (biomedcentral.com)
- Phylogenetic analysis of the type 3 fimbrial genes ( mrkABCD ) from 39 strains revealed they clustered into five distinct clades (A-E) ranging from one to twenty-three members. (biomedcentral.com)
- Our data provides additional evidence for the spread of type 3 fimbrial genes by lateral gene transfer. (biomedcentral.com)
- Type 3 fimbriae belong to the chaperone-usher class of fimbriae and are encoded by five genes ( mrkABCDF ) arranged in the same transcriptional orientation [ 29 , 37 ]. (biomedcentral.com)
- In this investigation, we have assessed the drug resistance and virulence genes as well as the molecular typing characteristics of 30 E. coli strains isolated from duck farms in the Zhanjiang area of China . (bvsalud.org)
- Polymerase chain reaction was used to detect the drug resistance and virulence genes as well as serotypes , and whole- genome sequencing was used to analyze the multilocus sequence typing . (bvsalud.org)
- The epidemic serotype was O81 (5/24), ST3856 was an epidemic sequence type, and strains I-9 and III-6 carried 11 virulence genes . (bvsalud.org)
- This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
Diagnostics2
- The infectious disease diagnostics segment accounted for the biggest share of the global molecular quality controls market in 2022. (bharatbook.com)
- Spartan Bioscience has unveiled the first assays for its molecular diagnostics device and promised further launches in food and water safety testing. (foodnavigator.com)
Genetics2
- For more information view our Department of Molecular and Human Genetics brochure . (bcm.edu)
- To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. (lu.se)
Genome3
- The entire genome of human papilloma virus type 1a was cloned in Escherichia coli using the plasmid pBR322 as vector. (pasteur.fr)
- A network dedicated to bacterial foodborne disease surveillance will standardise subtyping via WGS using whole genome multilocus sequence typing (wgMLST). (foodnavigator.com)
- For over 40 years, BCM has not only been making breakthrough discoveries in genome integrity, molecular evolution, gene regulation and brain function, we have been creating the tools and techniques that make these discoveries possible. (bcm.edu)
20225
- The independent controls segment accounted for the biggest share of the global molecular quality controls market in 2022. (bharatbook.com)
- Single-analyte controls accounted for the biggest share of the molecular quality controls market in 2022. (bharatbook.com)
- North America dominated the molecular quality controls market in 2022. (bharatbook.com)
- 2022) Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type. (plos.org)
- Nigéria, en décembre 2022 et publie depuis lors des rapports mensuels. (who.int)
Epidemiologic3
- The majority of the isolates, 68.2% (n=232), nique in the ongoing global molecular epidemiologic survey of were VNI (var. (cdc.gov)
- The aims of this study were the following: 1) to extend the from the environment, which primarily colonize the lung and molecular epidemiologic survey to other parts of the world, 2) subsequently invade the central nervous system (4). (cdc.gov)
- Molecular epidemiologic studies have mainly focused on candidiasis in humans, but rarely in animals, thus in-depth investigations on molecular typing and evolutionary relationships are still lacking. (springer.com)
Genomics2
- Recent advances in single cell genomics technologies have begun to increase our understanding of the molecular heterogeneity that exists in tumors with particular focus on gene expression and chromatin accessibility profiles. (dartmouth.edu)
- However, due to limitations in methods for certain sample types and high cost for single cell genomics, bulk tumor molecular profiling has been and remains widely used. (dartmouth.edu)
Heterogeneity3
- Thus, investigations to understand the cell type specific epigenetic heterogeneity and the cooperation among various molecular layers to regulate tumorigenesis are needed. (dartmouth.edu)
- Then, I shift my focus to characterize the cellular heterogeneity in pediatric central nervous system tumors and transcriptomic alterations associated with these tumors, while accounting for cell type composition, with single nuclei gene expression data. (dartmouth.edu)
- Together, these findings emphasize the need for consideration of cellular identity to determine molecular heterogeneity that exist in various cancer contexts. (dartmouth.edu)
Assays3
- Analysis of current and emerging blood typing, grouping and infectious disease NAT screening assays. (aarkstore.com)
- New product development opportunities for blood typing, grouping and infectious disease NAT assays and instrumentation with significant market appeal. (aarkstore.com)
- This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2. (linscottsdirectory.com)
Bacterial1
- Further work is now required to substantiate the clade structure reported here by examining more strains as well as other bacterial genera that make type 3 fimbriae and cause CAUTI. (biomedcentral.com)
Escherichia1
- Resistance and virulence gene analysis and molecular typing of Escherichia coli from duck farms in Zhanjiang, China. (bvsalud.org)
Kinematics2
- Based on our analysis of the ionized and molecular gas kinematics and millimeter continuum emission, these CO morphologies are most likely produced by active galactic nucleus (AGN) feedback in the form of outflows, jets, and/or shocks. (iac.es)
- We aim to shed light on the physical properties and kinematics of the molecular material in the nucleus of one of the closest type 2 active galaxies. (aanda.org)
Pharmacology2
- Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
- Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)
Tumors9
- The first question we wanted to tackle was whether there were other molecular features of the tumors that could help us explain why some people were well-served by chemotherapy," explained Louis M. Staudt, M.D., Ph.D. , of NCI's CCR, who led the new study. (nih.gov)
- Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. (medlineplus.gov)
- The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas. (medlineplus.gov)
- Tumors that form on the membrane that covers the brain and spinal cord (meninges) are also common in neurofibromatosis type 2. (medlineplus.gov)
- Research suggests that the loss of merlin allows cells, especially Schwann cells, to multiply too frequently and form the tumors characteristic of neurofibromatosis type 2. (medlineplus.gov)
- Almost everyone who is born with one NF2 variant acquires a second variant (known as a somatic variant) in these cells and develops the tumors characteristic of neurofibromatosis type 2. (medlineplus.gov)
- Tumors are composed of heterogeneous cell types each with its own unique molecular profiles. (dartmouth.edu)
- In this thesis, I utilize a multi-omic approach integrating DNA methylation, hydroxymethylation, chromatin accessibility, and gene expression profiles to investigate unique single cell type-specific features in 1) epithelial-to-mesenchymal transition and in 2) pediatric central nervous system tumors. (dartmouth.edu)
- Finally, I illustrate the cytosine modification alterations that occur predominantly in the progenitorlike cell types of pediatric central nervous system tumors with a multi-omic approach. (dartmouth.edu)
Isolates1
- 400 clinical and environ- that this variety causes most human cryptococcal infections mental isolates into eight major molecular types: VNI (var. (cdc.gov)
Reagents4
- Check out the general purpose transfection reagents for plasmids, siRNAs (plasmid + siRNA co-transfections) and CRISPR/Cas9 as well as highly specific transfection reagents that have been carefully optimised for different primary cell types and different cell lines. (cambio.co.uk)
- Why Cell Type-Specific Avalanche™ Transfection Reagents? (cambio.co.uk)
- Other unknown properties that cause the responses of cells to transfection reagents vary significantly: some types of cells, such as suspension culture cells, primary cells, or stem cells are especially difficult to transfect with general-purpose tranfection reagents. (cambio.co.uk)
- Cell type/cell line specific Avalanche ® transfection reagents - a series of transfection reagents that were designed and optimized specifically with ingredients, formulations, and protocols for each type of cell lines or primary cells, in order to ensure the highest levels of efficiency while keeping the toxicity levels minimal. (cambio.co.uk)
Humans1
- This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene. (wikipedia.org)
Biochemical2
- Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III" Clinical Chemistry and Laboratory Medicine , vol. 46, no. 9, 2008, pp. 1245-1249. (degruyter.com)
- This product has been used as molecular tool for various biochemical applications. (moleculardepot.com)
Prognosis1
- Prognosis varies by type. (msdmanuals.com)
Subunit1
- A novel high molecular weight glutenin subunit encoded by the Glu-1B locus was identified in the French genotype Bagou, which we named 1B × 6.5. (mdpi.com)
Summarizes2
- The present study review and summarizes the temporal spreading and molecular evolution of SARS-CoV-2 clades and variants worldwide. (unboundmedicine.com)
- This article summarizes the relationships between the molecular and physiological functions of these Ca 2+ channel proteins. (eurekaselect.com)
Chromosome1
- The location of this clock gene was delimited by the molecular mapping of chromosome aberrations at or very near the per locus. (nih.gov)
Cold molecular2
- Thus, although we do not find evidence for a significant impact of quasar feedback on the total molecular gas reservoirs and star formation rates, it appears to be modifying the distribution of cold molecular gas in the central kiloparsec of the galaxies. (iac.es)
- and (2) a cold molecular and dusty disk, traced by submillimetre continuum and line emission. (aanda.org)
Global molecular1
- The global molecular quality controls market is projected to reach USD 0.3 billion by 2028 from USD 0.2 billion in 2023, at a CAGR of 6.6% during the forecast period. (bharatbook.com)
Obesity and type 2 diabet3
- Creely SJ, McTernan PG, Kusminski CM (2007) Lipopolysaccharide activates an innateimmune system response in humanadipose tissue in obesity and type 2 diabetes. (springer.com)
- GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. (lu.se)
- The findings presented in this thesis provide biological mechanistic insights underlying epidemiological observations and may aid in developing precision medicine for obesity and type 2 diabetes. (lu.se)
Strains3
- Several molecular typing methods have been developed to differentiate between M. avium subspecies and strains, such as single nucleotide polymorphism (SNP) typing and mini-satellite sequence analysis-mycobacterial interspersed repetitive-unit variable-number tandem repeats (MIRU-VNTR) ( 5 ). (frontiersin.org)
- All of the strains examined caused type 3 fimbriae mediated agglutination of tannic acid treated human erythrocytes despite sequence variation in the mrkD -encoding adhesin gene. (biomedcentral.com)
- Type 3 fimbriae deletion mutants were constructed in 13 representative strains and were used to demonstrate a direct role for type 3 fimbriae in biofilm formation. (biomedcentral.com)
Clades1
- The COVID-19 pandemic has had a significant impact on global health worldwide and the present study provides an overview of the molecular evolution of SARS-CoV-2 lineage clades (from the Wuhan strain to the currently circulating lineages of the Omicron). (unboundmedicine.com)
20161
- In 2015-2016, a new group of type A trichothecene toxins, named NX, was described [ 7 , 8 ]. (actanaturae.ru)
Tumor2
- Therefore, we investigated the serum levels of LPS and zonulin (ZO-1, a marker of gut permeability) along with systemic levels of tumor necrosis factor-α (TNF-α) and Interleukin-6 (IL-6) in patients with type 2 diabetes mellitus (T2DM) compared to control subjects. (springer.com)
- Unlike most other autosomal dominant conditions, in which one altered copy of a gene in each cell is sufficient to cause the disorder, two copies of the NF2 gene must be altered to trigger tumor formation in neurofibromatosis type 2. (medlineplus.gov)
Isolate2
- However, in a few cases, molecular typing at subspecies level has been carried out and Mah has proved to be the most frequent isolate ( 6 , 7 , 9 ). (frontiersin.org)
- Our aims were (1) to isolate and molecular type the causative agent, and (2) to determine antibiotic susceptibility in vitro so as to ensure the most appropriate antimicrobial therapy for the dog. (frontiersin.org)
Serotypes1
- The similarity of the general architecture between the PTC-E(M) and the previously determined PTC-A(M) strongly suggests that the progenitor M complexes of all botulinum serotypes may have similar molecular arrangement, although the neurotoxins apparently can take very different conformation when they are released from the M complex. (nature.com)
Isolation3
- Here we describe the isolation, molecular typing, and antibiotic susceptibility testing of the causative agent of a rare case of generalized mycobacteriosis in a crossbred dog. (frontiersin.org)
- Results from SNPs typing of gyrB and ITS, as well as from MIRU-VNTR analysis suggested the isolation of a single strain of M. avium subsp. (frontiersin.org)
- On November 25, 1994, the Ministry of Health of Nicaragua announced the isolation of dengue type 3 (DEN-3) from two children hospitalized with minor hemorrhagic manifestations in Managua. (cdc.gov)
Diabetes mellitus1
- Pradhan JE, Manson N, Rifai JE et al (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. (springer.com)
Sequence3
- Further increase in the response (approximately 40%) was shown to be achievable when the recognition sequence of the molecular beacon was incorporated in the stem. (diva-portal.org)
- Improvement of the specificity of the molecular beacons was also achieved by the incorporation within their recognition sequence of a one-base mismatch. (diva-portal.org)
- Fourteen diploid sequence types (DSTs) including six new DSTs were determined. (springer.com)
Inhibit1
- Because ethaverine is structurally related to verapamil, it is likely that ethaverine acts by binding to the verapamil binding sites on the L-type calcium channels to inhibit channel activation and dihydropyridine binding. (aspetjournals.org)
Autosomal recessive2
- Type III glycogen storage disease (GSD III) is an autosomal recessive disease caused by mutations in the AGL gene, which codes for glycogen debranching enzyme. (medscape.com)
- These diseases are autosomal recessive, except for mucopolysaccharidosis type II, which is X-linked. (medscape.com)
Mechanism3
- The crystal structure explains the mechanism of molecular assembly of the complex and reveals several acidic clusters at the interface responsible for association at low acidic pH and disassociation at basic/neutral pH. (nature.com)
- Type IC is mainly found in archaea and has a similar mechanism as type IB. (jove.com)
- Our results indicate that context-dependent recruitment of alternative intracellular signaling pathways within a single sensory neuron type conveys opposite hedonic valences, thereby providing a robust mechanism for odorant encoding and discrimination at the periphery. (plos.org)
Mechanisms1
- Although mechanisms operating at the level of single sensory neuron types or sensilla in the periphery have also been implicated in this process [ 14 - 21 ], the contributions of sensory neurons to mediating odorant discrimination and olfactory behavioral plasticity are not fully understood. (plos.org)
Characteristics1
- Little is known about the molecular characteristics of subset of PC that doesn't carry KRAS mutations. (carislifesciences.com)
Infectious disease1
- Test volume and sales forecasts for over 40 blood typing, grouping and infectious disease screening tests, including NAT. (aarkstore.com)
Analysis4
- Guatemala, and Spain were typed by using M13 polymerase phism (RFLP), DNA hybridization studies, amplified frag- chain reaction-fingerprinting and orotidine monophosphate pyro- ment length polymorphism (AFLP), and polymerase chain phosphorylase ( URA5 ) gene restriction fragment length polymor- phsm analysis with Hha I and Sau 96I in a double digest. (cdc.gov)
- According to our analysis, these noncircular motions correspond to molecular outflows that are mostly coplanar with the CO disks in four of the QSO2s, and either to a coplanar inflow or vertical outflow in the case of J1010+0612. (iac.es)
- Freeze-dried, cross-linked bovine type I collagen: analysis of properties J Periodontol. (moleculardepot.com)
- The European Centre for Disease Prevention and Control (ECDC) has said improvements must be made after low scores in one parameter of an analysis looking at Listeria typing methods. (foodnavigator.com)
Usher1
- Complete ophthalmic examinations were conducted on two boys and two girls from two related Hutterite families diagnosed with Usher syndrome type I. DNA from patients and their parents was first evaluated for a mutation in exon 10 of the protocadherin-related 15 ( PCDH15 ) gene (c.1471delG), previously reported in southern Alberta Hutterite patients with Usher syndrome (USH1F). (molvis.org)
Platelets1
- We test your blood type each time you come to give blood or platelets, and we cross check the results with your previous donations to guard against any mix-ups" explains Sue Ismay (Scientific Director, Manufacturing and Quality). (lifeblood.com.au)
Study2
- gattii is geograph- study permitted us to determine the major molecular types and ically restricted to mainly tropical and subtropical regions their distribution within each participating country. (cdc.gov)
- In a study to determine how well contrast-enhanced ultrasonographic scans can characterize focal liver lesions in patients with GSD type Ia, Nguyen et al examined images from 8 benign hepatic adenomas associated with the disease. (medscape.com)
Lipid2
- In Asian Indians who are considered highly insulin resistant, the circulatory LPS levels, LPS activity, and ZO-1 were significantly increased in patients with type 2 diabetes and showed positive correlation with inflammatory markers and poor glycemic/lipid control. (springer.com)
- We tested its effects on single, dihydropyridine-sensitive, L-type calcium channels from porcine cardiac muscle, incorporated into planar lipid bilayers. (aspetjournals.org)
Subjects1
- Gokulakrishnan K, Mohanavalli KT, Monickaraj F et al (2009) Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and type 2 diabetes patients. (springer.com)
Deficiency4
- Glycogen storage disease type III (GSD-III) is an inborn error of glycogen metabolism caused by a deficiency of the glycogen debranching enzyme, amylo-1,6-glucosidase,4-α-glucanotransferase (AGL). (degruyter.com)
- Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease ( GSD type II , acid maltase deficiency), Cori disease (GSD type IIIa, debranching enzyme deficiency), McArdle disease ( GSD type V , myophosphorylase deficiency), and Tarui disease ( GSD type VII , phosphofructokinase deficiency). (medscape.com)
- One form, Von Gierke disease ( GSD type Ia , glucose-6-phosphatase deficiency), causes clinically significant end-organ disease with significant morbidity. (medscape.com)
- 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
Variants2
- We integrated dense genotyping data to map cell type-specific cis-expression quantitative trait loci and to link SLE-associated variants to cell type-specific expression. (nih.gov)
- Variants (also known as mutations) in the NF2 gene cause neurofibromatosis type 2. (medlineplus.gov)
Lineage1
- Catalog Number: B2010505 (100 ug) SARS-CoV-2 Spike RBD (Wild type) is a highly pure recombinant SARS-CoV-2 RBD from the origical wild type lineage expressed in insect cells. (linscottsdirectory.com)
Patients2
Markers1
- At least four types of molecularly and prognostically distinct medulloblastomas have been identified based on molecular markers. (msdmanuals.com)
Nuclei1
- The central engines of many active galactic nuclei (AGNs) are thought to be surrounded by warm molecular and dusty material in an axisymmetric geometry, thus explaining part of the observational diversity of active nuclei. (aanda.org)
Methods1
- 1: Ritti L. Type I Collagen Purification from Rat Tail Tendons Methods Mol Biol. (moleculardepot.com)
Search1
- Search, find, compare suppliers for SARS-CoV-2 Spike RBD (Wild type) products. (linscottsdirectory.com)
Cell type-specific3
- Why cell-type specific? (cambio.co.uk)
- Transfection-EZ Biosystems: Why cell-type specific? (cambio.co.uk)
- I determine associations between cell type-specific hydroxymethylation alterations with cell type-specific gene expression changes. (dartmouth.edu)
Mild1
- These outflow properties are intermediate between those of the mild molecular outflows measured for Seyfert galaxies and the fast and energetic outflows shown by ultra-luminous infrared galaxies. (iac.es)