Molecular Imprinting
alpha-Endorphin
Genomic Imprinting
Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels. (1/75)
(+info)The recombinational anatomy of a mouse chromosome. (2/75)
(+info)Analysis of ketoprofen and mefenamic acid by high-performance liquid chromatography with molecularly imprinted polymer as the stationary phase. (3/75)
A simple and sensitive high-performance liquid chromatographic method for simultaneous determination of ketoprofen and mefenamic acid in tablets has been developed. HPLC with UV detection (220 nm) was performed on an analytical column packed with molecularly imprinted polymer (MIP) as the stationary phase. The MIPs are prepared by bulk polymerisation followed by crushing and sieving to the desired particle size. In this paper, we selected ketoprofen, methacrylic acid, and ethylene glycoldimethacrylate as template, functional monomer, and crosslinker in the presence of chloroform as the solvent. The retention times of mefenamic acid and ketoprofen were approximately 5 and 20 min, respectively. In order to compare the chromatographic data from the stationary phase, separation factors (alpha) were given. The values of alpha were 4.36 approximately 4.39 and showed that the MIPs were able to recognize structurally subtle differences from the template molecule. The limits of detection for ketoprofen and mefenamic acid were found to be 0.029 and 0.038 (g/L), while the limits of quantitation were 0.097 and 0.127 (g/L), respectively. Our results showed good accuracy, indicating that a ketoprofen-selective polymer was suitable for ketoprofen and mefenamic acid separations. Therefore, the MIPs are certainly applied to commercial tablet analysis. (+info)Computational insights on sulfonamide imprinted polymers. (4/75)
(+info)Nanoimprinted thin films of reactive, azlactone-containing polymers: combining methods for the topographic patterning of cell substrates with opportunities for facile post-fabrication chemical functionalization. (5/75)
(+info)Examination of imprinting process with molsidomine as a template. (6/75)
(+info)An electrochemical sensor for phenylephrine based on molecular imprinting. (7/75)
Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples. (+info)Hybrid separation and detection device for analysis of benzene, toluene, ethylbenzene, and xylenes in complex samples. (8/75)
(+info)Molecular imprinting is a technique used in the production of polymer-based materials that have specific recognition sites for target molecules. It is a type of nanotechnology that involves creating a molecular template within a polymer matrix during its synthesis. The template is introduced into the polymer solution, and when the polymer hardens or sets, it takes on the shape and size of the template. After the template is removed, the resulting material has binding sites that are complementary in shape, size, and chemical functionality to the target molecule. These materials can then be used for various applications such as sensors, separations, drug delivery systems, and diagnostics.
Alpha-endorphin is a naturally occurring opioid peptide that is derived from the precursor protein proopiomelanocortin (POMC). It is one of several endorphins, which are endogenous opioid neuropeptides that bind to opiate receptors in the brain and play a role in pain regulation, reward, and addictive behaviors.
Alpha-endorphin is composed of 31 amino acids and is formed by the proteolytic cleavage of POMC in the anterior pituitary gland. It has been shown to have analgesic effects, as well as potential anxiolytic and antidepressant properties. However, its precise physiological functions and mechanisms of action are not fully understood.
In addition to alpha-endorphin, POMC can also be cleaved to produce other bioactive peptides, including adrenocorticotropic hormone (ACTH), beta-lipotropin, and several other endorphins, such as beta-endorphin and gamma-endorphin. These peptides have a range of physiological functions, including regulation of stress responses, appetite, and energy metabolism.
Genomic imprinting is a epigenetic process that leads to the differential expression of genes depending on their parental origin. It involves the methylation of certain CpG sites in the DNA, which results in the silencing of one of the two copies of a gene, either the maternal or paternal allele. This means that only one copy of the gene is active and expressed, while the other is silent.
This phenomenon is critical for normal development and growth, and it plays a role in the regulation of genes involved in growth and behavior. Genomic imprinting is also associated with certain genetic disorders, such as Prader-Willi and Angelman syndromes, which occur when there are errors in the imprinting process that lead to the absence or abnormal expression of certain genes.
It's important to note that genomic imprinting is a complex and highly regulated process that is not yet fully understood. Research in this area continues to provide new insights into the mechanisms underlying gene regulation and their impact on human health and disease.
In the context of medical definitions, polymers are large molecules composed of repeating subunits called monomers. These long chains of monomers can have various structures and properties, depending on the type of monomer units and how they are linked together. In medicine, polymers are used in a wide range of applications, including drug delivery systems, medical devices, and tissue engineering scaffolds. Some examples of polymers used in medicine include polyethylene, polypropylene, polystyrene, polyvinyl chloride (PVC), and biodegradable polymers such as polylactic acid (PLA) and polycaprolactone (PCL).