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Patterns of innovation organisation in service firms: postal survey results and theoretical models... the managerial model, the traditional industrial model, the neo-industrial model, the entrepreneurial model and the artisanal ... Statistical data are used to test the validity of a certain number of theoretical models of the organisation of innovation, in ... the managerial model, the traditional industrial model, the neo-industrial model, the entrepreneurial model and the artisanal ... "Patterns of innovation organisation in service firms: postal survey results and theoretical models," Post-Print halshs-01133139 ...
Theoretical Model | iMechanicaPostdoc Opening in Soft Robotics Modeling at Carnegie Mellon. *[Deadline: 30 Sep. 2017] EMMC16, March 26-28, Nantes, France - ... The Evaluation of Deformation and Fracture of Gilsocarbon Graphite Subject to Service Environments: Experimental and Modelling ...
"Theoretical modelling of momentum transfer function of bi-disperse porous...... occupying a bi-disperse porous medium by mapping the available experimental data to the theoretical model proposed by Nield and ... "Theoretical modelling of momentum transfer function of bi-disperse porous media" Applied Thermal Engineering Vol. 75 (2015) ... occupying a bi-disperse porous medium by mapping the available experimental data to the theoretical model proposed by Nield and ...
A single theoretical model of superconductivity?Home » Computation and theory » News » A single theoretical model of superconductivity? A single theoretical model of ... "We carried out a study based on theory and simulations that demonstrated that this is not the case: the theoretical explanation ... "However, demonstrating that there is a single theoretical framework explaining these phenomena could be an important step ... and they put forward some hypotheses as to the theoretical framework for this explanation, hypotheses which paradoxically liken ...
Theoretical Modeling of Cellular Physiology Direct24-D. Holcman modeling potassium dynamics, FENS, Spain July 212. 23- D. Holcman, Modeling the Synpatic Current in Neurobiology ... 91-A. Amitai, D. Holcman, beta-model application to DNA modeling in the nucleus, Phys. Rev E. 2013 ... 35- D. Holcman, Modeling viral and DNA trafficking in the cytoplasm of a cell J. of Statistical Physics. 127, 3, 471-494, 2007. ... 67- J. Reingruber D. Holcman, Transcription factor search for a DNA promoter in a three-state model Physical Review E, 84, 2, ...
Theoretical model of DNA-membrane contacts].Abstract A DNA-membrane complex model (DMC) is presented, in which specific sites of DNA, low molecular weight RNA, and a ... Sergei Sazhin Presentation - Modelling of Automotive Fuel Droplet Heating and Evaporation. PPT Version , PDF Version ... Abstract A DNA-membrane complex model (DMC) is presented, in which specific sites of DNA, low molecular weight RNA, and a ...
Theoretical Modeling of Cellular Physiology BioNewMetricsVisit our Open Access Applied math and computational Biology Project. Bionewmetrics. See also the Youtube BioNewMetrics presentation. ...
Theoretical Modeling of Cellular Physiology Summer programEach year the group of Theoretical Modeling of Cellular Physiology offers one position for a summer student (3 months from June ...
Theoretical Modeling of Cellular Physiology Upcoming eventsWorkshop :Modeling Axonal transport . Nov 3-8. 2014 The goal of this workshop is to bring together leading cell biologists, ... Mathematical Modelling of Complex Systems To celebrate its 10th birthday, the laboratory MAS has organized an international ... In the past decades, quantitative biology has been driven by new modelling-based stochastic dynamical systems and partial ... conference on "Mathematical Modelling of Complex Systems".. Neurophotonics 2013 October 1-4, 2013 The themes and methods we ...
Theoretical Modeling of Cellular Physiology Holcman's messageDear reader,. I am looking for one or two persons to cross for 3 weeks the Svalbard island. Pulkas only, no engine.. http://en.wikipedia.org/wiki/Svalbard. description : 20km/ day. The itinerary from longyearbyen to Ny Alensund.. Period : April.. Conditions : extremely motivated.. Training : in shape, used to cross country skying. runing 3 times a week.. Please contact : D. Holcman.. Short CV :. 1991 : Crossing France bycling.. 1992 : crossing North of spain. 1997 : crossing spain bycling. 2003-2004 : Mona-loa 4100m, Hawai.. ...
Programming Languages as Mathematical Representations | Lambda the UltimateI wouldn't so much disagree with the statement itself as object to [well, okay, be wary of :-) ] the apparent emphasis. Try this as a complement: the strengths of mathematics are caused by the flexibility and adaptivity of human thought. Here's another related proposition: the problems with type systems are caused by their explicitness and formality.. For a long time now we've had a strong economic motive to play up how "smart" our technology is. Also, for the past century and more we've been motivated to play up how "smart" evolution is, because we've been trying to get across to people why evolution is powerful enough to explain things traditionally explained by religion. We've had no comparably strong motive to figure out what makes us special, and when we did try to investigate it we've tended to focus on our ability to do particular tasks over and over (easy to test), which I suspect is entirely the wrong place to look for our essential strengths. The result of all this is that we've ended ...
New theory uncovers cancer's deep evolutio... ( TEMPE Ariz. -- A new way to look at ...)Health, ...TEMPE Ariz. -- A new way to look at cancer -- by tracing its deep evo...Davies and Lineweaver are both theoretical physicists and cosmologists...The new theory challenges the orthodox view that cancer develops anew ...Their view of cancer is outlined in the article Exposing cancer's dee...,New,theory,uncovers,cancer's,deep,evolutionary,roots,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Researchers air new theories about 1918 flu mortality | CIDRAP(CIDRAP News) - Experts who have studied the 1918 pandemic have long puzzled over why the mortality rate in young adults was so high, a feature that might be explained by pathologic immune responses related to previous flu exposure, according to a new theory from a research team.
LESSON 13: FACTORING THEORETICAL FRAMEWORK - PDFLESSON 13: FACTORING THEORETICAL FRAMEWORK Lesson Objectives To understand the Concept of Factoring. Methodology of Factoring and Forfeiting. Types of factoring. Introduction Receivables constitute a significant
A conceptual model for guiding the clustering analysisO autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia ...
No data available that match "Models, Theoretical"
(1/14889) Myths, models and mitigation of resistance to pesticides.
Resistance to pesticides in arthropod pests is a significant economic, ecological and public health problem. Although extensive research has been conducted on diverse aspects of pesticide resistance and we have learned a great deal during the past 50 years, to some degree the discussion about 'resistance management' has been based on 'myths'. One myth involves the belief that we can manage resistance. I will maintain that we can only attempt to mitigate resistance because resistance is a natural evolutionary response to environmental stresses. As such, resistance will remain an ongoing dilemma in pest management and we can only delay the onset of resistance to pesticides. 'Resistance management' models and tactics have been much discussed but have been tested and deployed in practical pest management programmes with only limited success. Yet the myth persists that better models will provide a 'solution' to the problem. The reality is that success in using mitigation models is limited because these models are applied to inappropriate situations in which the critical genetic, ecological, biological or logistic assumptions cannot be met. It is difficult to predict in advance which model is appropriate to a particular situation; if the model assumptions cannot be met, applying the model sometimes can increase the rate of resistance development rather than slow it down. Are there any solutions? I believe we already have one. Unfortunately, it is not a simple or easy one to deploy. It involves employing effective agronomic practices to develop and maintain a healthy crop, monitoring pest densities, evaluating economic injury levels so that pesticides are applied only when necessary, deploying and conserving biological control agents, using host-plant resistance, cultural controls of the pest, biorational pest controls, and genetic control methods. As a part of a truly multi-tactic strategy, it is crucial to evaluate the effect of pesticides on natural enemies in order to preserve them in the cropping system. Sometimes, pesticide-resistant natural enemies are effective components of this resistance mitigation programme. Another name for this resistance mitigation model is integrated pest management (IPM). This complex model was outlined in some detail nearly 40 years ago by V. M. Stern and colleagues. To deploy the IPM resistance mitigation model, we must admit that pest management and resistance mitigation programmes are not sustainable if based on a single-tactic strategy. Delaying resistance, whether to traditional pesticides or to transgenic plants containing toxin genes from Bacillus thuringiensis, will require that we develop multi-tactic pest management programmes that incorporate all appropriate pest management approaches. Because pesticides are limited resources, and their loss can result in significant social and economic costs, they should be reserved for situations where they are truly needed--as tools to subdue an unexpected pest population outbreak. Effective multi-tactic IPM programmes delay resistance (= mitigation) because the number and rates of pesticide applications will be reduced. (+info)
(2/14889) Referenceless interleaved echo-planar imaging.
Interleaved echo-planar imaging (EPI) is an ultrafast imaging technique important for applications that require high time resolution or short total acquisition times. Unfortunately, EPI is prone to significant ghosting artifacts, resulting primarily from system time delays that cause data matrix misregistration. In this work, it is shown mathematically and experimentally that system time delays are orientation dependent, resulting from anisotropic physical gradient delays. This analysis characterizes the behavior of time delays in oblique coordinates, and a new ghosting artifact caused by anisotropic delays is described. "Compensation blips" are proposed for time delay correction. These blips are shown to remove the effects of anisotropic gradient delays, eliminating the need for repeated reference scans and postprocessing corrections. Examples of phantom and in vivo images are shown. (+info)
(3/14889) Modeling breathing-zone concentrations of airborne contaminants generated during compressed air spray painting.
This paper presents a mathematical model to predict breathing-zone concentrations of airborne contaminants generated during compressed air spray painting in cross-flow ventilated booths. The model focuses on characterizing the generation and transport of overspray mist. It extends previous work on conventional spray guns to include exposures generated by HVLP guns. Dimensional analysis and scale model wind-tunnel studies are employed using non-volatile oils, instead of paint, to produce empirical equations for estimating exposure to total mass. Results indicate that a dimensionless breathing zone concentration is a nonlinear function of the ratio of momentum flux of air from the spray gun to the momentum flux of air passing through the projected area of the worker's body. The orientation of the spraying operation within the booth is also very significant. The exposure model requires an estimate of the contaminant generation rate, which is approximated by a simple impactor model. The results represent an initial step in the construction of more realistic models capable of predicting exposure as a mathematical function of the governing parameters. (+info)
(4/14889) The impact of a multidisciplinary approach on caring for ventilator-dependent patients.
OBJECTIVE: To determine the clinical and financial outcomes of a highly structured multidisciplinary care model for patients in an intensive care unit (ICU) who require prolonged mechanical ventilation. The structured model outcomes (protocol group) are compared with the preprotocol outcomes. DESIGN: Descriptive study with financial analysis. SETTING: A twelve-bed medical-surgical ICU in a non-teaching tertiary referral center in Ogden, Utah. STUDY PARTICIPANTS: During a 54 month period, 469 consecutive intensive care patients requiring mechanical ventilation for longer than 72 hours who did not meet exclusion criteria were studied. INTERVENTIONS: A multidisciplinary team was formed to coordinate the care of ventilator-dependent patients. Care was integrated by daily collaborative bedside rounds, monthly meetings, and implementation of numerous guidelines and protocols. Patients were followed from the time of ICU admission until the day of hospital discharge. MAIN OUTCOME MEASURES: Patients were assigned APACHE II scores on admission to the ICU, and were divided into eight diagnostic categories. ICU length of stay, hospital length of stay, costs, charges, reimbursement, and in-hospital mortality were measured. RESULTS: Mortality in the preprotocol and protocol group, after adjustment for APACHE II scores, remained statistically unchanged (21-23%). After we implemented the new care model, we demonstrated significant decreases in the mean survivor's ICU length of stay (19.8 days to 14.7 days, P= 0.001), hospital length of stay (34.6 days to 25.9 days, P=0.001), charges (US$102500 to US$78500, P=0.001), and costs (US$71900 to US$58000, P=0.001). CONCLUSIONS: Implementation of a structured multidisciplinary care model to care for a heterogeneous population of ventilator-dependent ICU patients was associated with significant reductions in ICU and hospital lengths of stay, charges, and costs. Mortality rates were unaffected. (+info)
(5/14889) Simultaneous measurement of evoked release and [Ca2+]i in a crayfish release bouton reveals high affinity of release to Ca2+.
The opener neuromuscular junction of crayfish was used to determine the affinity of the putative Ca2+ receptor(s) responsible for evoked release. Evoked, asynchronous release, and steady-state intracellular Ca2+ concentration, [Ca2+]ss, were measured concomitantly in single release boutons. It was found that, as expected, asynchronous release is highly correlated with [Ca2+]ss. Surprisingly, evoked release was also found to be highly correlated with [Ca2+]ss. The quantal content (m) and the rate of asynchronous release (S) showed sigmoidal dependence on [Ca2+]ss. The slope log m/log [Ca2+]ss varied between 1.6 and 3.3; the higher slope observed at the lower [Ca2+]o. The slope log S/log [Ca2+]ss varied between 3 and 4 and was independent of [Ca2+]o. These results are consistent with the assumption that evoked release is controlled by the sum of [Ca2+]ss and the local elevation of Ca2+ concentration near the release sites resulting from Ca2+ influx through voltage-gated Ca2+ channels (Y). On the basis of the above, we were able to estimate Y. We found Y to be significantly <10 microM even for [Ca2+]o = 13.5 mM. The dissociation constant (Kd) of the Ca2+ receptor(s) associated with evoked release was calculated to be in the range of 4-5 microM. This value of Kd is similar to that found previously for asynchronous release. (+info)
(6/14889) Resolution of fluorescence correlation measurements.
The resolution limit of fluorescence correlation spectroscopy for two-component solutions is investigated theoretically and experimentally. The autocorrelation function for two different particles in solution were computed, statistical noise was added, and the resulting curve was fitted with a least squares fit. These simulations show that the ability to distinguish between two different molecular species in solution depends strongly on the number of photons detected from each particle, their difference in size, and the concentration of each component in solution. To distinguish two components, their diffusion times must differ by at least a factor of 1.6 for comparable quantum yields and a high fluorescence signal. Experiments were conducted with Rhodamine 6G and Rhodamine-labeled bovine serum albumin. The experimental results support the simulations. In addition, they show that even with a high fluorescence signal but significantly different quantum yields, the diffusion times must differ by a factor much bigger than 1.6 to distinguish the two components. Depending on the quantum yields and the difference in size, there exists a concentration threshold for the less abundant component below which it is not possible to determine with statistical means alone that two particles are in solution. (+info)
(7/14889) Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epithelium.
1. The mammalian colonic epithelium carries out a number of different transporting activities simultaneously, of which more than one is increased following activation with a single agonist. These separate activities can be quantified by solving a set of equations describing these activities, provided some of the dependent variables can be eliminated. Using variations in the experimental conditions, blocking drugs and comparing wild type tissues with those from transgenic animals this has been achieved for electrogenic ion transporting activity of the mouse colon. 2. Basal activity and that following activation with forskolin was measured by short circuit current in isolated mouse colonic epithelia from normal and cystic fibrosis (CF) mice. 3. Using amiloride it is shown that CF colons show increased electrogenic sodium absorption compared to wild type tissues. CF mice had elevated plasma aldosterone, which may be responsible for part or all of the increased sodium absorbtion in CF colons. 4. The derived values for electrogenic chloride secretion and for electrogenic potassium secretion were increased by 13 and 3 fold respectively by forskolin, compared to basal state values for these processes. 5. The loop diuretic, frusemide, completely inhibited electrogenic potassium secretion, but apparently only partially inhibited electrogenic chloride secretion. However, use of bicarbonate-free solutions and acetazolamide reduced the frusemide-resistant current, suggesting that electrogenic bicarbonate secretion accounts for the frusemide-resistant current. 6. It is argued that the use of tissues from transgenic animals is an important adjunct to pharmacological analysis, especially where effects in tissues result in the activation of more than one sort of response. (+info)
(8/14889) Stretching lattice models of protein folding.
A new class of experiments that probe folding of individual protein domains uses mechanical stretching to cause the transition. We show how stretching forces can be incorporated in lattice models of folding. For fast folding proteins, the analysis suggests a complex relation between the force dependence and the reaction coordinate for folding. (+info)
- 6- D. Holcman, Multiscale modeling, stochastic and asymptotic approaches for analyzing neural networks based on synaptic dynamics, ESAIM: Proceedings and Surveys 47, 36-54 2015. (ens.fr)
- In the past decades, quantitative biology has been driven by new modelling-based stochastic dynamical systems and partial differential equations. (ens.fr)
- G. Malherbe D. Holcman, Stochastic modeling of gene activation and application to cell regulation, J. Th.Bio 2010. (ens.fr)
- 4- Z. Schuss D. Holcman, Time scales of Diffusion for Molecular and Cellular processes, J.Phys A: Mathematical and Theoretical 47 (17), 1730012014. (ens.fr)
- Because synapses are still unavailable to direct experimental recordings, mathematical modeling and simulations have been used to analyze their functions. (ens.fr)
- In their new paper, Capone and co-workers demonstrate that the explanation is the same, and they put forward some hypotheses as to the theoretical framework for this explanation, hypotheses which paradoxically liken superconductivity and very high impedance phenomena. (materialstoday.com)
- But if we want to treat education scientifically so we can accumulate, evaluate, and refine what we learn, then we must develop a theoretical framework that is strongly rooted in objective observations and through which different theoretical models of student thinking can be compared. (umd.edu)
- In this paper, I draw from a variety of fields ranging from neuroscience to sociolinguistics to propose an over-arching theoretical framework that allows us to both make sense of what we see in the classroom and to compare a variety of specific theoretical approaches. (umd.edu)
- The goal of this class is to present modeling methods to study cellular microdomains and in particular synapses, which are local micro contacts between neurons. (ens.fr)
- The present methods are general and can be applied to various microdomains where there is a low molecular number and thus most of the existing models based on continuum concepts, in which the medium is assumed homogeneous cannot be applied. (ens.fr)
- In that case, to obtain quantitative information about chemical processes, modeling and simulations seem to be inevitable to reconstruct the microdomains environment and to obtain precise quantitative information about the molecular dynamics. (ens.fr)
- 9- N. Rouach, D Holcman, Modeling neuron-glia interactions (invited chapter) Springer. (ens.fr)
- 1- T. Lagache, E. Dauty, D. Holcman, Physical principles and models describing intracellular virus particle dynamics, Current Opinion in Microbiology;12(4):439-45 (2009). (ens.fr)
- T. Lagache E. Dauty D. Holcman, Physical principles and models describing intracellular virus particle dynamics, Current Opinion in Microbiology, 12,4 (2009). (ens.fr)
- Modeling of Neuron-Gli interactions. (ens.fr)
- The group is currently working on modeling cellular biology and we are involved in identifying principles underlying the cell function in normal and pathological conditions. (ens.fr)
- We carried out a study based on theory and simulations that demonstrated that this is not the case: the theoretical explanation for copper and iron superconductors could be the same, and could even apply to other materials like carbon, for example carbon fullerides, which have been extensively studied at SISSA. (materialstoday.com)
- Multiscale modeling in neuroscience. (ens.fr)
- The aim of this paper is to obtain the momentum transfer coefficient between the two phases, denoted by f and p, occupying a bi-disperse porous medium by mapping the available experimental data to the theoretical model proposed by Nield and Kuznetsov . (bepress.com)
- Finally, we will study the motion of mARN or fundamental proteins transported in the nucleus, some models of gene activation and some physical principle associated with DNA repair. (ens.fr)
- Modeling diffusion of shaped object, law of reflection, polymer dynamics using Rouse model. (ens.fr)
- Abstract A DNA-membrane complex model (DMC) is presented, in which specific sites of DNA, low molecular weight RNA, and a system of two lipid (or lipoprotein) membranes take part, Morphological identity of these complexes and nuclear pores for eucaryotes and "Bayer's junctions" for procaryotes is suggested. (omicsonline.org)
- The modern approach of modeling cellular biological systems requires many branches of theoretical physics, mathematics and chemistry. (ens.fr)
- In addition, it is necessary to include to the list the biological fields of interest and some knowledge of theoretical chemistry. (ens.fr)
- A model based on statistical mechanics is applied to describe a key factor determining the senescence of biological cells. (ens.fr)
- For each level, I sketch some plausible starting models for student thinking and learning in physics and give examples of how a theoretical orientation can affect instruction and research. (umd.edu)
- The study reported here developed and tested a model of EIS usage. (bl.uk)
- Each year the group of Theoretical Modeling of Cellular Physiology offers one position for a summer student (3 months from June to September). (ens.fr)
- In the second part, we will focus on telomere organization (ends of the chromosomes) and introduce a model of aggregation-dissociation to describe telomere clustering. (ens.fr)
- Patterns of innovation organisation in service firms: postal survey results and theoretical models ," Post-Print halshs-01133139, HAL. (repec.org)
- The results provided considerable support to the research model. (bl.uk)
- Statistical data are used to test the validity of a certain number of theoretical models of the organisation of innovation, in particular the professionals in partnership model, the managerial model, the traditional industrial model, the neo-industrial model, the entrepreneurial model and the artisanal or craft model. (repec.org)
- The model was tested against data from 216 EIS users across various organisations. (bl.uk)
- The proposed model integrates key constructs from the information systems success factors research stream into the theoretical frame of the technology acceptance model and other theories from social psychology (the theory of reasoned action, the theory of planned behaviour, and the Triandis model of attitude and behaviour). (bl.uk)
- S. Pillay, A. Peirce, and T. Kolokolnikov, M. Ward, An Asymptotic Analysis of the Mean First Passage Time for Narrow Escape Problems : Part I : Two-Dimensional Domains (SIAM Multiscale Modeling and Simulation, (March 2009), 28 pages. (ens.fr)
- A. Cheviakov and R. Straube M. Ward, An Asymptotic Analysis of the Mean First Passage Time for Narrow Escape Problems : Part II : The Sphere (SIAM Multiscale Modeling and Simulation, (March 2009), 32 pages. (ens.fr)