No data available that match "Models, Genetic"
A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters | UBC Department of...A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters. ... A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters. ... A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters. ... A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters ...
Use of Pleiotropy to Model Genetic Interactions in a PopulationOur method generates data-driven models and testable hypotheses of how the genetic variation in a population combines to affect ... We tested this method using a population of yeast strains with random combinations of five genetic mutations and derived an ... It is designed to be flexible and scalable for application to populations with extensive genetic diversity. ... approach that uses the complementary information encoded by multiple phenotypes in conjunction with genetic data to map genetic ...
PLOS Biology: Understanding Cannabinoid Psychoactivity with Mouse Genetic ModelsThanks to recent advances in the cannabinoid field, investigators have begun to relate cannabis's cellular mechanisms to its psychoactive behavioral effects.
Voltage-dependant anion channels: novel insights into isoform function through genetic models... ... Here, we review the approaches used to create these insect and mammalian animal models, and the conclusions reached by studying ... the consequences of loss of function mutations on the genetic, physiologic, and biochemical properties of the resulting models ... with the generation of animal models of VDAC deficiency providing much of the available information about isoform-specific ...
Mixing Energy Models in Genetic Algorithms for On-Lattice Protein Structure Prediction : Algorithm 8Algorithm 8: The pseudocode of evaluation procedure ...
Oxidative stress in genetic mouse models of Parkinson's disease.Genetic Models and Environmental Challenge To complete our understanding of the genetic contribution to PD, a full ... the identification of PD-associated genes has led to the development of new genetic animal models of PD . While many models ... Genetic animal models of Parkinson's diseaseNeuronYear: 201066564666120547124. 23. Farrer MJ. Genetics of Parkinson disease: ... As the current genetic models of PD do not reproduce the complete disease pattern, the influence of genes, environment, and the ...
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of...Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of ...
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease... in the substantia nigra of an AAV-based rat genetic model of Parkinson's disease (PD). In this model, daily exposure of both ... Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. ... may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human ...
Modeling Human Liver Cancer Heterogeneity: Virally Induced Transgenic Models and Mouse Genetic Models of Chronic Liver...Modeling Human Liver Cancer Heterogeneity: Virally Induced Transgenic Models and Mouse Genetic Models of Chronic Liver ... Mouse models of hepatocellular carcinoma. Semin. Liver Dis. 30:87‐98.. Freeman, A.J., Dore, G.J., Law, M.G., Thorpe, M., Von ... Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL‐6 and TNF expression. Cell 140:197‐208 ... Drug development over the past 15 years has focused on generating mouse models that mimic the human pathology for HCC. This has ...
Model Discusses Rare Genetic Condition Affecting Her AppearanceMeet a young woman with a rare genetic condition that dramatically affects her appearance. Plus, see the incredible surprises ... Melanie, 26, is a successful international, high-fashion model with a unique appearance. She was born with a rare genetic ...
Genetic Models... Pharmacology Faculty. Barrett, Paula Q.. Regulation of low-voltage activated T-type Ca2+ channel activity by ...
"Development of a hybrid support vector machine and genetic algorithm model for regime identification of slurry transport in...The method incorporates hybrid support vector machine and genetic algorithm technique (SVM-GA) for efficient tuning of SVM meta ... Development of a hybrid support vector machine and genetic algorithm model for regime identification of slurry transport in ... "Development of a hybrid support vector machine and genetic algorithm model for regime identification of slurry transport in ... The method incorporates hybrid support vector machine and genetic algorithm technique (SVM-GA) for efficient tuning of SVM meta ...
KAKEN - Research Projects | Investigation of the role of MHC class I molecule on the demyelination in a model of genetic...Investigation of the role of MHC class I molecule on the demyelination in a model of genetic demyelination. Research Project ... which is a murine model of genetic demyelinating disease, globoid cell leukodystrophy.The crossbreeding of beta2-microglobulin- ... Publications] M.Taniike et al.: 'An apoptotic depletion of oligodendrocytes in the twitcher,a murine model of globoid cell ... Publications] M.Taniike et al.: 'An apoptotic depletion of oligodendrocytes in the twitcher, a murine model of globoid cell ...
Frontiers | On the underlying assumptions of threshold Boolean networks as a model for genetic regulatory network behavior |...... and synergistic regulation while maintaining their Markovian nature increases the applicability of these models to genetic ... and synergistic regulation while maintaining their Markovian nature increases the applicability of these models to genetic ... Specifying these models with fewer parameters while retaining their ability to describe complex regulatory relationships is an ... Specifying these models with fewer parameters while retaining their ability to describe complex regulatory relationships is an ...
The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model | Disease Models & MechanismsThis profile of the Drd1 mutant rat offers the field of neuroscience a novel genetic rat model to study a series of psychiatric ... We describe a novel rat model with a genetic mutation in the Drd1, in which we measured basic behavioural phenotypes and social ... Review - Mouse models of metastasis: progress and prospects. Currently available mouse models of metastasis are reviewed by ... The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model ...
Alternating evolutionary pressure in a genetic algorithm facilitates protein model selectionHome » Alternating evolutionary pressure in a genetic algorithm facilitates protein model selection ... on model accuracy (when compared to that of corresponding single-template based models) is not clear. To address this, we ... This problem is approached in a twofold manner; simple lattice models are used to represent protein structures with the ability ... Conclusion: This approach improves the overall performance of the GA by allowing models to overcome local energy barriers. AEP ...
Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor - Garvan Institute of Medical...To clarify NPY's role in schizophrenia, we investigated a genetic animal model for Y(1) deficiency in regard to (i) acoustic ... To clarify NPY's role in schizophrenia, we investigated a genetic animal model for Y(1) deficiency in regard to (i) acoustic ... Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia patients. Importantly ... Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia patients. Importantly ...
Model Melanie Gaydos Has a Rare Genetic Disorder-And She's Taking Over the Fashion WorldMelanie Gaydos is a model with ectodermal dysplasia and a crazy-inspiring outlook. ... Model Melanie Gaydos Has a Rare Genetic Disorder-And She's Taking Over the Fashion World. Gaydos has ectodermal dysplasia-which ... Gaydos also name drops albino model Shaun Ross and Winnie Harlow, a former America's Next Top Model contestant turned super ... As with other genetic disorders, ED can be inherited or occur due to a mutated gene at conception. Approximately 1 in 10,000 ...
Models of experimental evolution: the role of genetic chance and selective necessity.23952685 - Integrating models and data to estimate the structural reliability of utility poles dur.... 18245845 - Multivariate ... 16783015 - Population models of genomic imprinting. ii. maternal and fertility selection.. 16592685 - Equivalence of maximizing ...
Analysis of GEMMs helps unravel genetic heterogeneity in colorectal cancer | Disease Models & MechanismsYour Name) has sent you a message from Disease Models & Mechanisms Message Body (Your Name) thought you would like to see the ... Genetically engineered mouse models (GEMMs) have been widely used to explore cancer biology and establish targeted cancer ... Damian C. Crowther and colleagues summarise in a new Review how studies in Drosophila and mouse models accelerate our ... Sporadic CRC is difficult to mimic in preclinical animal models because of its heterogeneous nature, which has contributed to ...
PubZone - A Mathematical Model for Vehicle-Occupant Frontal Crash Using Genetic Algorithm. (Rating)A Mathematical Model for Vehicle-Occupant Frontal Crash Using Genetic Algorithm. Rate this publication. If you log in you may ...
Random regression models on Legendre polynomials to estimate genetic parameters for weights from birth to adult age in Canchim...... to derive relevant genetic parameters for growth traits in Canchim cattle. ... The objective of this work was to estimate covariance functions for direct and maternal genetic effects, animal and maternal ... A total of 12 random regression models from second to seventh order were used to model direct and maternal genetic effects, ... Random regression models on Legendre polynomials to estimate genetic parameters for weights from birth to adult age in Canchim ...
A Unifying Model for the Analysis of Phenotypic, Genetic and Geographic Data - DTU OrbitA Unifying Model for the Analysis of Phenotypic, Genetic and Geographic Data. Publication: Research - peer-review › Journal ... it allows one to analyze genetic and phenotypic data within a unied model and inference framework, thus opening the way to ... A Spatial Model for the Instantaneous Estimation of Wind Power at a Large Number of Unobserved Sites. Publication: Research - ... Spatial models for probabilistic prediction of wind power with application to annual-average and high temporal resolution data ...
A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin.In particular, an EDS variant is caused by a genetic mutation res ... A mouse model of spontaneous preterm birth based on the genetic ... Thus, the biglycan/decorin null mutant mouse is a model of genetically induced preterm birth and perinatal loss. This model ... Disease Models, Animal*. Ehlers-Danlos Syndrome / metabolism, pathology, physiopathology, prevention & control. Extraembryonic ... In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two ...
Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood AsthmaIn the noncausal model, a common familial predisposition to asthma is associated with winter viral infection and asthma and is ... It seems implausible, however, that those with a genetic predisposition to asthma have differential seasonal fertility or that ... Noncausal and causal models of the relationship between winter viral infection and early childhood asthma. ... Univariate and multivariable logistic regression models were constructed to analyze the relationship of infant age in days at ...
No data available that match "Models, Genetic"
(1/26926) A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder.
Inherited defects in the degradation of glycosphingolipids (GSLs) cause a group of severe diseases known as GSL storage disorders. There are currently no effective treatments for the majority of these disorders. We have explored a new treatment paradigm, substrate deprivation therapy, by constructing a genetic model in mice. Sandhoff's disease mice, which abnormally accumulate GSLs, were bred with mice that were blocked in their synthesis of GSLs. The mice with simultaneous defects in GSL synthesis and degradation no longer accumulated GSLs, had improved neurologic function, and had a much longer life span. However, these mice eventually developed a late-onset neurologic disease because of accumulation of another class of substrate, oligosaccharides. The results support the validity of the substrate deprivation therapy and also highlight some limitations. (+info)
(2/26926) A computational screen for methylation guide snoRNAs in yeast.
Small nucleolar RNAs (snoRNAs) are required for ribose 2'-O-methylation of eukaryotic ribosomal RNA. Many of the genes for this snoRNA family have remained unidentified in Saccharomyces cerevisiae, despite the availability of a complete genome sequence. Probabilistic modeling methods akin to those used in speech recognition and computational linguistics were used to computationally screen the yeast genome and identify 22 methylation guide snoRNAs, snR50 to snR71. Gene disruptions and other experimental characterization confirmed their methylation guide function. In total, 51 of the 55 ribose methylated sites in yeast ribosomal RNA were assigned to 41 different guide snoRNAs. (+info)
(3/26926) Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance.
OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. METHODS: Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with > or =2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. RESULTS: Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. CONCLUSION: Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including beta2-glycoprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas. (+info)
(4/26926) Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice.
To study the effect of continued telomere shortening on chromosome stability, we have analyzed the telomere length of two individual chromosomes (chromosomes 2 and 11) in fibroblasts derived from wild-type mice and from mice lacking the mouse telomerase RNA (mTER) gene using quantitative fluorescence in situ hybridization. Telomere length at both chromosomes decreased with increasing generations of mTER-/- mice. At the 6th mouse generation, this telomere shortening resulted in significantly shorter chromosome 2 telomeres than the average telomere length of all chromosomes. Interestingly, the most frequent fusions found in mTER-/- cells were homologous fusions involving chromosome 2. Immortal cultures derived from the primary mTER-/- cells showed a dramatic accumulation of fusions and translocations, revealing that continued growth in the absence of telomerase is a potent inducer of chromosomal instability. Chromosomes 2 and 11 were frequently involved in these abnormalities suggesting that, in the absence of telomerase, chromosomal instability is determined in part by chromosome-specific telomere length. At various points during the growth of the immortal mTER-/- cells, telomere length was stabilized in a chromosome-specific man-ner. This telomere-maintenance in the absence of telomerase could provide the basis for the ability of mTER-/- cells to grow indefinitely and form tumors. (+info)
(5/26926) Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicase.
The replication initiator protein RepD encoded by the Staphylococcus chloramphenicol resistance plasmid pC221 stimulates the helicase activity of the Bacillus stearothermophilus PcrA DNA helicase in vitro. This stimulatory effect seems to be specific for PcrA and differs from the stimulatory effect of the Escherichia coli ribosomal protein L3. Whereas L3 stimulates the PcrA helicase activity by promoting co-operative PcrA binding onto its DNA substrate, RepD stimulates the PcrA helicase activity by increasing the processivity of the enzyme and enables PcrA to displace DNA from a nicked substrate. The implication of these results is that PcrA is the helicase recruited into the replisome by RepD during rolling circle replication of plasmids of the pT181 family. (+info)
(6/26926) Transplacement mutagenesis: a novel in situ mutagenesis system using phage-plasmid recombination.
Site-specific mutagenesis provides the ability to alter DNA with precision so that the function of any given gene can be more fully understood. Several methods of in vitro mutagenesis are time-consuming and imprecise, requiring the subcloning and sequencing of products. Here we describe a rapid, high fidelity method of in situ mutagenesis in bacteriophage lambda using transplacement. Using this method, mutations are transferred from oligonucleotides to target phages using a plasmid interface. A small (50 bp) homology region bearing a centred point mutation is generated from oligonucleotides and subcloned into a transplacement plasmid bearing positive and negative phage selectable markers. Following a positive/negative selection cycle of integrative recombination and excision, the point mutation is transferred precisely from plasmid to phage in a subset ( approximately 25-50%) of recombinants. As the fidelity of both oligonucleotide synthesis and phage-plasmid recombination is great, this approach is extremely reliable. Using transplacement, point mutations can be accurately deposited within large phage clones and we demonstrate the utility of this technique in the construction of gene targeting vectors in bacteriophages. (+info)
(7/26926) Rapid modification of bacterial artificial chromosomes by ET-recombination.
We present a method to modify bacterial artificial chromosomes (BACs) resident in their host strain. The method is based on homologous recombination by ET-cloning. We have successfully modified BACs at two distinct loci by recombination with a PCR product containing homology arms of 50 nt. The procedure we describe here is rapid, was found to work with high efficiency and should be applicable to any BAC modification desired. (+info)
(8/26926) Amplification of cDNA ends based on template-switching effect and step-out PCR.
A new method for amplifying cDNA ends is described which requires only first-strand cDNA synthesis and a single PCR to generate a correct product with very low or no background. The method can be successfully applied to total RNA as well as poly A+ RNA. The same first-strand cDNA can be used to amplify flanking sequences of any cDNA species present in the sample. (+info)
- The method incorporates hybrid support vector machine and genetic algorithm technique (SVM-GA) for efficient tuning of SVM meta-parameters. (bepress.com)
- She was born with a rare genetic disorder called ectodermal dysplasia, which affects the epidermal layer of the skin and therefore her hair, skin, nails, teeth and glands. (thedoctorstv.com)
- She was born with ectodermal dysplasia*, an umbrella term for a host of genetic conditions that affected the development of her hair, teeth, and nails. (esquire.com)
- Results: In the context of an automatic modelling pipeline, we analysed each step separately, revealing several non-intuitive trends and explored a new strategy for protein conformation sampling using Genetic Algorithms (GA). We apply the concept of alternating evolutionary pressure (AEP), i.e. intermediate rounds within the GA runs where unrestrained, linear growth of the model populations is allowed. (ebscohost.com)
- We describe a novel rat model with a genetic mutation in the Drd1, in which we measured basic behavioural phenotypes and social cognition. (biologists.org)
- The dynamic models range from highly quantitative frameworks such as systems of differential equations [see Heinrich and Schuster (1996) for an introduction] to more qualitative models such as Boolean networks (BoN) ( Kauffman, 1969 ). (frontiersin.org)
- This profile of the Drd1 mutant rat offers the field of neuroscience a novel genetic rat model to study a series of psychiatric disorders including schizophrenia, autism, depression, bipolar disorder and drug addiction. (biologists.org)
- Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia patients. (garvan.org.au)
- To clarify NPY's role in schizophrenia, we investigated a genetic animal model for Y(1) deficiency in regard to (i) acoustic startle response (ASR), (ii) habituation to ASR and (iii) sensorimotor gating [i.e. prepulse inhibition (PPI)] using two different PPI protocols. (garvan.org.au)
- Translating the well-described in vitro characteristics of the VDAC isoforms into in vivo functions has been a challenge, with the generation of animal models of VDAC deficiency providing much of the available information about isoform-specific roles in biology. (omicsonline.org)
- Additionally, extending these models to incorporate variable gene decay rates, asynchronous gene response, and synergistic regulation while maintaining their Markovian nature increases the applicability of these models to genetic regulatory networks (GRN). (frontiersin.org)
- Genetic regulation is either positive, resulting in increased gene expression, or negative, resulting in decreased gene expression. (frontiersin.org)
- Dynamic models are used frequently to study the evolution of a genetic regulatory network (GRN) over time [see De Jong (2002) for a review]. (frontiersin.org)
- Models of experimental evolution: the role of genetic chance and selective necessity. (biomedsearch.com)
- Taken into consideration the importance of ageing and environmental factors as a risk for developing Parkinson's disease, gene-environment interactions in genetically engineered mouse models of Parkinson's disease are also discussed, highlighting the role of oxidative damage in the interplay between genetic makeup, environmental stress, and ageing in Parkinson's disease. (biomedsearch.com)
- Gene expression analysis in HBV transgenic mouse liver: A model to study early events related to hepatocarcinogenesis. (currentprotocols.com)
- Boolean networks (BoN) are relatively simple and interpretable models of gene regulatory networks. (frontiersin.org)
- Is the Subject Area "Genetic interactions" applicable to this article? (plos.org)
- Population models of genomic imprinting. (biomedsearch.com)
- Specifying these models with fewer parameters while retaining their ability to describe complex regulatory relationships is an ongoing methodological challenge. (frontiersin.org)
- Rodriguez et al.have been performed extensive studies about the pathological role of MHC class I on the demyelination using virus-induced demyelination and he suggested that the existence of this molecule is essential for the progression of demyelination and the occurrence of neurological deficits.Thus it is important to examine the forthcoming F2 and F3 progeny to see if his conclusion is also the case in this genetic demyelination. (nii.ac.jp)
- Conclusion: This approach improves the overall performance of the GA by allowing models to overcome local energy barriers. (ebscohost.com)
- Oxidative stress in genetic mouse models of Parkinson's disease. (biomedsearch.com)
- Furthermore, an overview of the existing genetic mouse models of Parkinson's disease is given and the evidence of oxidative stress in these models highlighted. (biomedsearch.com)
- Chimeric mouse model of hepatitis B virus infection. (currentprotocols.com)
- In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson's disease (PD). (epfl.ch)
- Here, we review the approaches used to create these insect and mammalian animal models, and the conclusions reached by studying the consequences of loss of function mutations on the genetic, physiologic, and biochemical properties of the resulting models. (omicsonline.org)
- Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. (epfl.ch)
- We note that the introduction of variable degradation compromises the Markovian property fundamental to BoN models but show that a simple state augmentation procedure restores their Markovian nature. (frontiersin.org)
- Nevertheless, there are still potential improvements to be made in template selection, refinement and protein model selection. (ebscohost.com)