Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties.
Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Cetyltrimethylammonium compounds that have cationic detergent, antiseptic, and disinfectant activities. They are used in pharmaceuticals, foods, and cosmetics as preservatives; on skin, mucous membranes, etc., as antiseptics or cleansers, and also as emulsifiers. These compounds are toxic when used orally due to neuromuscular blockade.
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Relating to the size of solids.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Dimethylamines are organic compounds that contain two methyl groups (-CH3) bonded to a nitrogen atom (N), with the general formula (CH3)2NH. They can act as secondary amines and are commonly used in chemical synthesis, but they are not typically found as natural components in the human body.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Glucosides are glycosides that contain glucose as the sugar component, often forming part of the plant's defense mechanism and can have various pharmacological effects when extracted and used medically.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
A trihydroxy bile salt that is used as a digestive aid in dietary supplements. It is used in culture media and in conjunction with PAPAIN and PANCREATIN.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Measurement of the intensity and quality of fluorescence.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Colipase I and II, consisting of 94-95 and 84-85 amino acid residues, respectively, have been isolated from porcine pancreas. Their role is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
The thermodynamic interaction between a substance and WATER.
Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
The rate dynamics in chemical or physical systems.
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Spherical particles of nanometer dimensions.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Biophysical characterization of the structure of the amino-terminal region of gp41 of HIV-1. Implications on viral fusion mechanism. (1/2247)

A peptide of 51 amino acids corresponding to the NH2-terminal region (5-55) of the glycoprotein gp41 of human immunodeficiency virus type 1 was synthesized to study its conformation and assembly. Nuclear magnetic resonance experiments indicated the sequence NH2-terminal to the leucine zipper-like domain of gp41 was induced into helix in the micellar solution, in agreement with circular dichroism data. Light scattering experiment showed that the peptide molecules self-assembled in water into trimeric structure on average. That the peptide molecules oligomerize in aqueous solution was supported by gel filtration and diffusion coefficient experiments. Molecular dynamics simulation based on the NMR data revealed a flexible region adjacent to the hydrophobic NH2 terminus of gp41. The biological significance of the present findings on the conformational flexibility and the propensity of oligomerization of the peptide may be envisioned by a proposed model for the interaction of gp41 with membranes during fusion process.  (+info)

Further studies on the mechanism of adrenaline-induced lipolysis in lipid micelles. (2/2247)

Lipase [EC 3.1.1.3] depleted lipid micelles, in which lipolysis was not elicited by adrenaline, were prepared from lipid micelles. When these lipase-depleted lipid micelles incubated with adipose tissue extract containing lipase activity, adrenaline-induced lipolysis was restored to almost the same level as that of native lipid micelles. Adrenaline-induced lipolysis was not restored when the lipase-depleted lipid micelles were homogenized or sonicated. Various tissue extracts from kidney, lung, liver, and pancreas, and post-heparin plasma, which contained lipase activity, restored adrenaline-induced lipolysis in lipase-depleted lipid micelles.  (+info)

Folding of apocytochrome c induced by the interaction with negatively charged lipid micelles proceeds via a collapsed intermediate state. (3/2247)

Unfolded apocytochrome c acquires an alpha-helical conformation upon interaction with lipid. Folding kinetic results below and above the lipid's CMC, together with energy transfer measurements of lipid bound states, and salt-induced compact states in solution, show that the folding transition of apocytochrome c from the unfolded state in solution to a lipid-inserted helical conformation proceeds via a collapsed intermediate state (I(C)). This initial compact state is driven by a hydrophobic collapse of the polypeptide chain in the absence of the heme group and may represent a heme-free analogue of an early compact intermediate detected on the folding pathway of cytochrome c in solution. Insertion into the lipid phase occurs via an unfolding step of I(C) through a more extended state associated with the membrane surface (I(S)). While I(C) appears to be as compact as salt-induced compact states in solution with substantial alpha-helix content, the final lipid-inserted state (Hmic) is as compact as the unfolded state in solution at pH 5 and has an alpha-helix content which resembles that of native cytochrome c.  (+info)

Molecular dynamics study of substance P peptides in a biphasic membrane mimic. (4/2247)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in a TIP3P water/CCl4 biphasic solvent system as a mimic for the water-membrane system. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) in the equilibration stage of the simulation. The starting orientation/position of the peptides for the MD simulation was either parallel to the water/CCl4 interface or in a perpendicular/insertion mode. In both cases the peptides equilibrated and adopted a near-parallel orientation within approximately 250 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained in the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbone of nearly all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions with the hydrophobic phase come from the hydrophobic interactions of the side chains of Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, and Phe-7, Leu-10, Met-11 and, to a lesser extent, Tyr-8 in SP-Y8. Concerted conformational transitions took place in the time frame of hundreds of picoseconds. The concertedness of the transition was due to the tendency of the peptide to maintain the necessary secondary structure to position the peptide properly with respect to the water/CCl4 interface.  (+info)

Molecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelle. (5/2247)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) during the equilibration stage of the simulation. It was shown that when SP-Y8 was initially placed in an insertion (perpendicular) configuration, the peptide equilibrated to a surface-bound (parallel) configuration in approximately 450 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained from the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbones of all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions come from the hydrophobic interaction between the side chains of Lys-3, Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, from Lys-3, Phe-7, Leu-10, and Met-11 in SP-Y8, and the micellar interior. Significant interactions, electrostatic and hydrogen bonding, between the N-terminal residues, Arg-Pro-Lys, and the micellar headgroups were observed. These latter interactions served to affect both the structure and, especially, the flexibility, of the N-terminus. The results from simulation of the same peptides in a water/CCl4 biphasic cell were compared with the results of the present study, and the validity of using the biphasic system as an approximation for peptide-micelle or peptide-bilayer systems is discussed.  (+info)

Cryoelectron microscopy of a nucleating model bile in vitreous ice: formation of primordial vesicles. (6/2247)

Because gallstones form so frequently in human bile, pathophysiologically relevant supersaturated model biles are commonly employed to study cholesterol crystal formation. We used cryo-transmission electron microscopy, complemented by polarizing light microscopy, to investigate early stages of cholesterol nucleation in model bile. In the system studied, the proposed microscopic sequence involves the evolution of small unilamellar to multilamellar vesicles to lamellar liquid crystals and finally to cholesterol crystals. Small aliquots of a concentrated (total lipid concentration = 29.2 g/dl) model bile containing 8.5% cholesterol, 22.9% egg yolk lecithin, and 68.6% taurocholate (all mole %) were vitrified at 2 min to 20 days after fourfold dilution to induce supersaturation. Mixed micelles together with a category of vesicles denoted primordial, small unilamellar vesicles of two distinct morphologies (sphere/ellipsoid and cylinder/arachoid), large unilamellar vesicles, multilamellar vesicles, and cholesterol monohydrate crystals were imaged. No evidence of aggregation/fusion of small unilamellar vesicles to form multilamellar vesicles was detected. Low numbers of multilamellar vesicles were present, some of which were sufficiently large to be identified as liquid crystals by polarizing light microscopy. Dimensions, surface areas, and volumes of spherical/ellipsoidal and cylindrical/arachoidal vesicles were quantified. Early stages in the separation of vesicles from micelles, referred to as primordial vesicles, were imaged 23-31 min after dilution. Observed structures such as enlarged micelles in primordial vesicle interiors, segments of bilayer, and faceted edges at primordial vesicle peripheries are probably early stages of small unilamellar vesicle assembly. A decrease in the mean surface area of spherical/ellipsoidal vesicles was correlated with the increased production of cholesterol crystals at 10-20 days after supersaturation by dilution, supporting the role of small unilamellar vesicles as key players in cholesterol nucleation and as cholesterol donors to crystals. This is the first visualization of an intermediate structure that has been temporally linked to the development of small unilamellar vesicles in the separation of vesicles from micelles in a model bile and suggests a time-resolved system for further investigation.  (+info)

Lipid exchange between mixed micelles of phospholipid and triton X-100. (7/2247)

If phospholipase catalyzed hydrolysis of phospholipid dissolved in a detergent mixed micelle is limited to the phospholipid carried by a single micelle, then hydrolysis ceases upon exhaustion of that pool. However, if the rate of phospholipid exchange between micelles exceeds the catalytic rate then all of the phospholipid is available for hydrolysis. To determine phospholipid availability we studied the exchange of 1,2-dioleoyl-sn-glycero-3-phosphocholine between mixed micelles of phospholipid and non-ionic Triton detergents by both stopped-flow fluorescence-recovery and nuclear magnetic resonance-relaxation techniques. Stopped-flow analysis was performed by combining mixed micelles of Triton and phospholipid with mixed micelles that contained the fluorescent phospholipid 1-palmitoyl-2-(12-[{7-nitro-2-1, 3-benzoxadiazo-4-yl}amino]dodecanoyl)-sn-glycero-3-phosphocholine (P-2-NBD-PC). The concentration dependence of fluorescence recovery suggested a second-order exchange mechanism that was saturable. The true second-order rate constant depends on the specific mechanism for exchange, which was not determined in this study, but the rate constant will be on the order of 106 to 107 M-1s-1. Incorporation of 1-palmitoyl-2-(16-doxylstearoyl)phosphatidylcholine into micelles increased the rate of proton relaxation and gave a limiting relaxation time of 1.3 ms. The results demonstrate that phospholipid exchange was rapid and that the phospholipid content of a single micelle did not limit the rate of phospholipid hydrolysis by phospholipases.  (+info)

Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes. (8/2247)

We examined the effects of quinaprilat, an active metabolite of quinapril (an angiotensin converting enzyme (ACE) inhibitor) on the increase in intracellular concentration of Ca2+ ([Ca2+]i) (Ca2+-overload) induced by lysophosphatidylcholine (LPC) in isolated rat cardiomyocytes. LPC (15 microM) produced Ca2+-overload with a change in cell-shape from rod to round. Quinaprilat but not quinapril at 20 or 50 microM attenuated the LPC-induced increase in [Ca2+]i and the change in cell-shape in a concentration-dependent manner. Since quinaprilat has an inhibitory action on ACE and quinapril has practically no inhibitory action on ACE, it is likely that the inhibitory action of quinaprilat on ACE is necessary for the protective effect of the drug against LPC-induced changes. We therefore examined the effects of enalapril (another ACE inhibitor with the weak inhibitory action on ACE) and enalaprilat (an active metabolite of enalapril with an inhibitory action on ACE) on the LPC-induced changes. Both enalapril and enalaprilat attenuated the LPC-induced Ca2+-overload, suggesting that the inhibitory action on ACE may not mainly contribute to the protective effect of ACE inhibitors against LPC-induced Ca2+-overload. This suggestion was supported by the fact that neither ACE (0.2 U/ml) nor angiotensin II (0.1-100 microM) increased [Ca2+]i in isolated cardiomyocytes. Furthermore, application of bradykinin (0.01-10 microM) did not enhance the protective effect of quinaprilat against LPC-induced changes. LPC also increased release of creatine kinase (CK) from the myocyte markedly, and quinaprilat but not quinapril attenuated the LPC-induced CK release. Unexpectedly, both enalapril and enalaprilat did not attenuate the LPC-induced CK release. Neither quinapril nor quinaprilat changed the critical micelle concentration of LPC, suggesting that these drugs do not directly bind to LPC. We conclude that quinaprilat attenuates the LPC-induced increase in [Ca2+]i, and that the protective effect of quinaprilat on the LPC-induced change may not be related to a decrease in angiotensin II production or an increase in bradykinin production.  (+info)

Micelles are structures formed in a solution when certain substances, such as surfactants, reach a critical concentration called the critical micelle concentration (CMC). At this concentration, these molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) components, arrange themselves in a spherical shape with the hydrophilic parts facing outward and the hydrophobic parts clustered inside. This formation allows the hydrophobic components to avoid contact with water while the hydrophilic components interact with it. Micelles are important in various biological and industrial processes, such as drug delivery, soil remediation, and the formation of emulsions.

Colloids are a type of mixture that contains particles that are intermediate in size between those found in solutions and suspensions. These particles range in size from about 1 to 1000 nanometers in diameter, which is smaller than what can be seen with the naked eye, but larger than the molecules in a solution.

Colloids are created when one substance, called the dispersed phase, is dispersed in another substance, called the continuous phase. The dispersed phase can consist of particles such as proteins, emulsified fats, or finely divided solids, while the continuous phase is usually a liquid, but can also be a gas or a solid.

Colloids are important in many areas of medicine and biology, including drug delivery, diagnostic imaging, and tissue engineering. They are also found in nature, such as in milk, blood, and fog. The properties of colloids can be affected by factors such as pH, temperature, and the presence of other substances, which can influence their stability and behavior.

Polyethylene glycols (PEGs) are a family of synthetic, water-soluble polymers with a wide range of molecular weights. They are commonly used in the medical field as excipients in pharmaceutical formulations due to their ability to improve drug solubility, stability, and bioavailability. PEGs can also be used as laxatives to treat constipation or as bowel cleansing agents prior to colonoscopy examinations. Additionally, some PEG-conjugated drugs have been developed for use in targeted cancer therapies.

In a medical context, PEGs are often referred to by their average molecular weight, such as PEG 300, PEG 400, PEG 1500, and so on. Higher molecular weight PEGs tend to be more viscous and have longer-lasting effects in the body.

It's worth noting that while PEGs are generally considered safe for use in medical applications, some people may experience allergic reactions or hypersensitivity to these compounds. Prolonged exposure to high molecular weight PEGs has also been linked to potential adverse effects, such as decreased fertility and developmental toxicity in animal studies. However, more research is needed to fully understand the long-term safety of PEGs in humans.

A drug carrier, also known as a drug delivery system or vector, is a vehicle that transports a pharmaceutical compound to a specific site in the body. The main purpose of using drug carriers is to improve the efficacy and safety of drugs by enhancing their solubility, stability, bioavailability, and targeted delivery, while minimizing unwanted side effects.

Drug carriers can be made up of various materials, including natural or synthetic polymers, lipids, inorganic nanoparticles, or even cells and viruses. They can encapsulate, adsorb, or conjugate drugs through different mechanisms, such as physical entrapment, electrostatic interaction, or covalent bonding.

Some common types of drug carriers include:

1. Liposomes: spherical vesicles composed of one or more lipid bilayers that can encapsulate hydrophilic and hydrophobic drugs.
2. Polymeric nanoparticles: tiny particles made of biodegradable polymers that can protect drugs from degradation and enhance their accumulation in target tissues.
3. Dendrimers: highly branched macromolecules with a well-defined structure and size that can carry multiple drug molecules and facilitate their release.
4. Micelles: self-assembled structures formed by amphiphilic block copolymers that can solubilize hydrophobic drugs in water.
5. Inorganic nanoparticles: such as gold, silver, or iron oxide nanoparticles, that can be functionalized with drugs and targeting ligands for diagnostic and therapeutic applications.
6. Cell-based carriers: living cells, such as red blood cells, stem cells, or immune cells, that can be loaded with drugs and used to deliver them to specific sites in the body.
7. Viral vectors: modified viruses that can infect cells and introduce genetic material encoding therapeutic proteins or RNA interference molecules.

The choice of drug carrier depends on various factors, such as the physicochemical properties of the drug, the route of administration, the target site, and the desired pharmacokinetics and biodistribution. Therefore, selecting an appropriate drug carrier is crucial for achieving optimal therapeutic outcomes and minimizing side effects.

Surfactants, also known as surface-active agents, are amphiphilic compounds that reduce the surface tension between two liquids or between a liquid and a solid. They contain both hydrophilic (water-soluble) and hydrophobic (water-insoluble) components in their molecular structure. This unique property allows them to interact with and stabilize interfaces, making them useful in various medical and healthcare applications.

In the medical field, surfactants are commonly used in pulmonary medicine, particularly for treating respiratory distress syndrome (RDS) in premature infants. The lungs of premature infants often lack sufficient amounts of natural lung surfactant, which can lead to RDS and other complications. Exogenous surfactants, derived from animal sources or synthetically produced, are administered to replace the missing or dysfunctional lung surfactant, improving lung compliance and gas exchange.

Surfactants also have applications in topical formulations for dermatology, as they can enhance drug penetration into the skin, reduce irritation, and improve the spreadability of creams and ointments. Additionally, they are used in diagnostic imaging to enhance contrast between tissues and improve visualization during procedures such as ultrasound and X-ray examinations.

I'm sorry for any confusion, but "octanes" is not a medical term. It is a term used in chemistry and physics, particularly in reference to fuel. Octane is a hydrocarbon molecule found in gasoline, and it is used as a measure of the fuel's ability to resist engine knocking or pinging during combustion.

The octane rating of gasoline typically ranges from 87 (regular) to 91-93 (premium). Higher-octane fuels are often recommended for high-performance vehicles that have higher compression ratios in their engines. If you have any questions related to medical terminology, I'd be happy to help!

Detergents are cleaning agents that are often used to remove dirt, grease, and stains from various surfaces. They contain one or more surfactants, which are compounds that lower the surface tension between two substances, such as water and oil, allowing them to mix more easily. This makes it possible for detergents to lift and suspend dirt particles in water so they can be rinsed away.

Detergents may also contain other ingredients, such as builders, which help to enhance the cleaning power of the surfactants by softening hard water or removing mineral deposits. Some detergents may also include fragrances, colorants, and other additives to improve their appearance or performance.

In a medical context, detergents are sometimes used as disinfectants or antiseptics, as they can help to kill bacteria, viruses, and other microorganisms on surfaces. However, it is important to note that not all detergents are effective against all types of microorganisms, and some may even be toxic or harmful if used improperly.

It is always important to follow the manufacturer's instructions when using any cleaning product, including detergents, to ensure that they are used safely and effectively.

Phosphorylcholine is not a medical condition or disease, but rather a chemical compound. It is the choline ester of phosphoric acid, and it plays an important role in the structure and function of cell membranes. Phosphorylcholine is also found in certain types of lipoproteins, including low-density lipoprotein (LDL) or "bad" cholesterol.

In the context of medical research and therapy, phosphorylcholine has been studied for its potential role in various diseases, such as atherosclerosis, Alzheimer's disease, and other inflammatory conditions. Some studies have suggested that phosphorylcholine may contribute to the development of these diseases by promoting inflammation and immune responses. However, more research is needed to fully understand the role of phosphorylcholine in human health and disease.

Sodium dodecyl sulfate (SDS) is not primarily used in medical contexts, but it is widely used in scientific research and laboratory settings within the field of biochemistry and molecular biology. Therefore, I will provide a definition related to its chemical and laboratory usage:

Sodium dodecyl sulfate (SDS) is an anionic surfactant, which is a type of detergent or cleansing agent. Its chemical formula is C12H25NaO4S. SDS is often used in the denaturation and solubilization of proteins for various analytical techniques such as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), a method used to separate and analyze protein mixtures based on their molecular weights.

When SDS interacts with proteins, it binds to the hydrophobic regions of the molecule, causing the protein to unfold or denature. This process disrupts the natural structure of the protein, exposing its constituent amino acids and creating a more uniform, negatively charged surface. The negative charge results from the sulfate group in SDS, which allows proteins to migrate through an electric field during electrophoresis based on their size rather than their native charge or conformation.

While not a medical definition per se, understanding the use of SDS and its role in laboratory techniques is essential for researchers working in biochemistry, molecular biology, and related fields.

Solubility is a fundamental concept in pharmaceutical sciences and medicine, which refers to the maximum amount of a substance (solute) that can be dissolved in a given quantity of solvent (usually water) at a specific temperature and pressure. Solubility is typically expressed as mass of solute per volume or mass of solvent (e.g., grams per liter, milligrams per milliliter). The process of dissolving a solute in a solvent results in a homogeneous solution where the solute particles are dispersed uniformly throughout the solvent.

Understanding the solubility of drugs is crucial for their formulation, administration, and therapeutic effectiveness. Drugs with low solubility may not dissolve sufficiently to produce the desired pharmacological effect, while those with high solubility might lead to rapid absorption and short duration of action. Therefore, optimizing drug solubility through various techniques like particle size reduction, salt formation, or solubilization is an essential aspect of drug development and delivery.

In the context of medical definitions, polymers are large molecules composed of repeating subunits called monomers. These long chains of monomers can have various structures and properties, depending on the type of monomer units and how they are linked together. In medicine, polymers are used in a wide range of applications, including drug delivery systems, medical devices, and tissue engineering scaffolds. Some examples of polymers used in medicine include polyethylene, polypropylene, polystyrene, polyvinyl chloride (PVC), and biodegradable polymers such as polylactic acid (PLA) and polycaprolactone (PCL).

Cetrimonium compounds are a type of chemical compound that contain cetrimonium as the active ingredient. Cetrimonium is a quaternary ammonium compound that has antimicrobial and surfactant properties. It is commonly used in personal care products such as shampoos, conditioners, and cosmetics as a preservative and to improve the product's ability to spread and wet surfaces.

Cetrimonium compounds are often used as a alternative to formaldehyde-releasing preservatives, which have been linked to health concerns. They work by disrupting the bacterial cell membrane, leading to cell death. Cetrimonium compounds are also effective against fungi and viruses.

In addition to their use in personal care products, cetrimonium compounds are also used in medical settings as a antiseptic and disinfectant. They are often found in products used to clean and disinfect medical equipment and surfaces.

It is important to note that while cetrimonium compounds have been deemed safe for use in personal care products and medical settings, they can cause irritation and allergic reactions in some people. It is always recommended to do a patch test before using a new product containing cetrimonium compounds.

Octoxynol is a type of surfactant, which is a compound that lowers the surface tension between two substances, such as oil and water. It is a synthetic chemical that is composed of repeating units of octylphenoxy polyethoxy ethanol.

Octoxynol is commonly used in medical applications as a spermicide, as it is able to disrupt the membrane of sperm cells and prevent them from fertilizing an egg. It is found in some contraceptive creams, gels, and films, and is also used as an ingredient in some personal care products such as shampoos and toothpastes.

In addition to its use as a spermicide, octoxynol has been studied for its potential antimicrobial properties, and has been shown to have activity against certain viruses, bacteria, and fungi. However, its use as an antimicrobial agent is not widely established.

It's important to note that octoxynol can cause irritation and allergic reactions in some people, and should be used with caution. Additionally, there is some concern about the potential for octoxynol to have harmful effects on the environment, as it has been shown to be toxic to aquatic organisms at high concentrations.

I'm sorry for any confusion, but "Polyesters" is not a medical term. It is a term used in materials science and textile industry to describe a type of synthetic fiber made from polymers characterized by the presence of ester groups in their main chain. If you have any questions related to medical terminology or concepts, I'd be happy to help with those instead!

In the context of medical and health sciences, particle size generally refers to the diameter or dimension of particles, which can be in the form of solid particles, droplets, or aerosols. These particles may include airborne pollutants, pharmaceutical drugs, or medical devices such as nanoparticles used in drug delivery systems.

Particle size is an important factor to consider in various medical applications because it can affect the behavior and interactions of particles with biological systems. For example, smaller particle sizes can lead to greater absorption and distribution throughout the body, while larger particle sizes may be filtered out by the body's natural defense mechanisms. Therefore, understanding particle size and its implications is crucial for optimizing the safety and efficacy of medical treatments and interventions.

Magnetic Resonance Spectroscopy (MRS) is a non-invasive diagnostic technique that provides information about the biochemical composition of tissues, including their metabolic state. It is often used in conjunction with Magnetic Resonance Imaging (MRI) to analyze various metabolites within body tissues, such as the brain, heart, liver, and muscles.

During MRS, a strong magnetic field, radio waves, and a computer are used to produce detailed images and data about the concentration of specific metabolites in the targeted tissue or organ. This technique can help detect abnormalities related to energy metabolism, neurotransmitter levels, pH balance, and other biochemical processes, which can be useful for diagnosing and monitoring various medical conditions, including cancer, neurological disorders, and metabolic diseases.

There are different types of MRS, such as Proton (^1^H) MRS, Phosphorus-31 (^31^P) MRS, and Carbon-13 (^13^C) MRS, each focusing on specific elements or metabolites within the body. The choice of MRS technique depends on the clinical question being addressed and the type of information needed for diagnosis or monitoring purposes.

Dimethylamine is an organic compound with the formula (CH3)2NH. It is a colorless gas that is highly soluble in water and polar solvents. Dimethylamine is a derivative of ammonia (NH3) in which two hydrogen atoms are replaced by methyl groups (CH3).

Dimethylamines, in medical terminology, typically refer to compounds that contain the functional group -N(CH3)2. These compounds can have various biological activities and may be used as drugs or therapeutic agents. For example, dimethylamine is a metabolite of choline, a nutrient important for brain function.

However, it's worth noting that "dimethylamines" is not typically used as a medical term to describe a specific condition or diagnosis. If you have any concerns about exposure to dimethylamine or its potential health effects, it would be best to consult with a healthcare professional.

Drug delivery systems (DDS) refer to techniques or technologies that are designed to improve the administration of a pharmaceutical compound in terms of its efficiency, safety, and efficacy. A DDS can modify the drug release profile, target the drug to specific cells or tissues, protect the drug from degradation, and reduce side effects.

The goal of a DDS is to optimize the bioavailability of a drug, which is the amount of the drug that reaches the systemic circulation and is available at the site of action. This can be achieved through various approaches, such as encapsulating the drug in a nanoparticle or attaching it to a biomolecule that targets specific cells or tissues.

Some examples of DDS include:

1. Controlled release systems: These systems are designed to release the drug at a controlled rate over an extended period, reducing the frequency of dosing and improving patient compliance.
2. Targeted delivery systems: These systems use biomolecules such as antibodies or ligands to target the drug to specific cells or tissues, increasing its efficacy and reducing side effects.
3. Nanoparticle-based delivery systems: These systems use nanoparticles made of polymers, lipids, or inorganic materials to encapsulate the drug and protect it from degradation, improve its solubility, and target it to specific cells or tissues.
4. Biodegradable implants: These are small devices that can be implanted under the skin or into body cavities to deliver drugs over an extended period. They can be made of biodegradable materials that gradually break down and release the drug.
5. Inhalation delivery systems: These systems use inhalers or nebulizers to deliver drugs directly to the lungs, bypassing the digestive system and improving bioavailability.

Overall, DDS play a critical role in modern pharmaceutical research and development, enabling the creation of new drugs with improved efficacy, safety, and patient compliance.

A nanocapsule is a type of nanoparticle that is characterized by its hollow, spherical structure. It is composed of a polymeric membrane that encapsulates an inner core or "cargo" which can be made up of various substances such as drugs, proteins, or imaging agents. The small size of nanocapsules (typically ranging from 10 to 1000 nanometers in diameter) allows them to penetrate cells and tissue more efficiently than larger particles, making them useful for targeted drug delivery and diagnostic applications.

The polymeric membrane can be designed to be biodegradable or non-biodegradable, depending on the desired application. Additionally, the surface of nanocapsules can be functionalized with various moieties such as antibodies, peptides, or small molecules to enhance their targeting capabilities and improve their stability in biological environments.

Overall, nanocapsules have great potential for use in a variety of medical applications, including cancer therapy, gene delivery, and vaccine development.

Poloxamers are a type of triblock copolymer made up of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). They are amphiphilic molecules, meaning they have both hydrophilic and hydrophobic parts.

Poloxamers are often used in the pharmaceutical industry as drug delivery agents, emulsifiers, solubilizers, and stabilizers. They can form micelles in aqueous solutions above their critical micelle concentration (CMC), with the hydrophobic chains oriented toward the interior of the micelle and the hydrophilic chains on the exterior, interacting with the water molecules. This unique property allows poloxamers to solubilize drugs that are otherwise poorly soluble in water, improving their bioavailability.

Poloxamers have been studied for various medical applications, including as drug carriers for chemotherapy, diagnostic agents, and mucoadhesive materials. Some specific poloxamer compounds have been approved by the FDA for use in pharmaceutical formulations, such as Poloxamer 188 and Poloxamer 407.

In a medical context, poloxamers are not typically used as standalone treatments but rather as components of drug delivery systems or formulations.

Glucosides are chemical compounds that consist of a glycosidic bond between a sugar molecule (typically glucose) and another non-sugar molecule, which can be an alcohol, phenol, or steroid. They occur naturally in various plants and some microorganisms.

Glucosides are not medical terms per se, but they do have significance in pharmacology and toxicology because some of them may release the sugar portion upon hydrolysis, yielding aglycone, which can have physiological effects when ingested or absorbed into the body. Some glucosides are used as medications or dietary supplements due to their therapeutic properties, while others can be toxic if consumed in large quantities.

Medical definitions of water generally describe it as a colorless, odorless, tasteless liquid that is essential for all forms of life. It is a universal solvent, making it an excellent medium for transporting nutrients and waste products within the body. Water constitutes about 50-70% of an individual's body weight, depending on factors such as age, sex, and muscle mass.

In medical terms, water has several important functions in the human body:

1. Regulation of body temperature through perspiration and respiration.
2. Acting as a lubricant for joints and tissues.
3. Facilitating digestion by helping to break down food particles.
4. Transporting nutrients, oxygen, and waste products throughout the body.
5. Helping to maintain healthy skin and mucous membranes.
6. Assisting in the regulation of various bodily functions, such as blood pressure and heart rate.

Dehydration can occur when an individual does not consume enough water or loses too much fluid due to illness, exercise, or other factors. This can lead to a variety of symptoms, including dry mouth, fatigue, dizziness, and confusion. Severe dehydration can be life-threatening if left untreated.

Nuclear Magnetic Resonance (NMR) Biomolecular is a research technique that uses magnetic fields and radio waves to study the structure and dynamics of biological molecules, such as proteins and nucleic acids. This technique measures the magnetic properties of atomic nuclei within these molecules, specifically their spin, which can be influenced by the application of an external magnetic field.

When a sample is placed in a strong magnetic field, the nuclei absorb and emit electromagnetic radiation at specific frequencies, known as resonance frequencies, which are determined by the molecular structure and environment of the nuclei. By analyzing these resonance frequencies and their interactions, researchers can obtain detailed information about the three-dimensional structure, dynamics, and interactions of biomolecules.

NMR spectroscopy is a non-destructive technique that allows for the study of biological molecules in solution, which makes it an important tool for understanding the function and behavior of these molecules in their natural environment. Additionally, NMR can be used to study the effects of drugs, ligands, and other small molecules on biomolecular structure and dynamics, making it a valuable tool in drug discovery and development.

I believe there might be a slight confusion in your question. Sodium cholate is not a medical term, but it is related to the field of biochemistry and physiology. Sodium cholate is a type of bile salt, which is a surfactant that helps in the digestion and absorption of fats in the body.

To provide a more detailed definition:

Sodium cholate (also known as sodium deoxycholate) is a conjugated bile salt, formed from the bacterial modification of primary bile acids (cholic acid) in the intestine. It is a sodium salt of deoxycholic acid, which is a secondary bile acid produced by intestinal bacteria. Bile salts like sodium cholate play an essential role in emulsifying dietary lipids, facilitating their breakdown by enzymes and subsequent absorption in the small intestine.

While not a medical definition per se, understanding bile salts like sodium cholate is important for comprehending various physiological processes, including digestion and liver function.

Phosphatidylcholines (PtdCho) are a type of phospholipids that are essential components of cell membranes in living organisms. They are composed of a hydrophilic head group, which contains a choline moiety, and two hydrophobic fatty acid chains. Phosphatidylcholines are crucial for maintaining the structural integrity and function of cell membranes, and they also serve as important precursors for the synthesis of signaling molecules such as acetylcholine. They can be found in various tissues and biological fluids, including blood, and are abundant in foods such as soybeans, eggs, and meat. Phosphatidylcholines have been studied for their potential health benefits, including their role in maintaining healthy lipid metabolism and reducing the risk of cardiovascular disease.

Taurodeoxycholic acid (TDCA) is a bile acid, which is a type of organic compound that is produced in the liver and essential for the digestion and absorption of fats. It is a conjugated bile acid, meaning it is formed from the combination of a deoxycholic acid with a taurine molecule.

TDCA helps to emulsify dietary fats, making them easier to absorb in the small intestine. It also plays a role in the elimination of cholesterol from the body by promoting its conversion into bile acids and excretion through the digestive system.

Abnormal levels of TDCA and other bile acids have been associated with various medical conditions, including liver disease, gallstones, and intestinal disorders. Therefore, measuring the levels of TDCA in blood or other bodily fluids can provide valuable diagnostic information for these conditions.

Circular dichroism (CD) is a technique used in physics and chemistry to study the structure of molecules, particularly large biological molecules such as proteins and nucleic acids. It measures the difference in absorption of left-handed and right-handed circularly polarized light by a sample. This difference in absorption can provide information about the three-dimensional structure of the molecule, including its chirality or "handedness."

In more technical terms, CD is a form of spectroscopy that measures the differential absorption of left and right circularly polarized light as a function of wavelength. The CD signal is measured in units of millidegrees (mdeg) and can be positive or negative, depending on the type of chromophore and its orientation within the molecule.

CD spectra can provide valuable information about the secondary and tertiary structure of proteins, as well as the conformation of nucleic acids. For example, alpha-helical proteins typically exhibit a strong positive band near 190 nm and two negative bands at around 208 nm and 222 nm, while beta-sheet proteins show a strong positive band near 195 nm and two negative bands at around 217 nm and 175 nm.

CD spectroscopy is a powerful tool for studying the structural changes that occur in biological molecules under different conditions, such as temperature, pH, or the presence of ligands or other molecules. It can also be used to monitor the folding and unfolding of proteins, as well as the binding of drugs or other small molecules to their targets.

In the context of medical terminology, "solutions" refers to a homogeneous mixture of two or more substances, in which one substance (the solute) is uniformly distributed within another substance (the solvent). The solvent is typically the greater component of the solution and is capable of dissolving the solute.

Solutions can be classified based on the physical state of the solvent and solute. For instance, a solution in which both the solvent and solute are liquids is called a liquid solution or simply a solution. A solid solution is one where the solvent is a solid and the solute is either a gas, liquid, or solid. Similarly, a gas solution refers to a mixture where the solvent is a gas and the solute can be a gas, liquid, or solid.

In medical applications, solutions are often used as vehicles for administering medications, such as intravenous (IV) fluids, oral rehydration solutions, eye drops, and topical creams or ointments. The composition of these solutions is carefully controlled to ensure the appropriate concentration and delivery of the active ingredients.

Radiation scattering is a physical process in which radiation particles or waves deviate from their original direction due to interaction with matter. This phenomenon can occur through various mechanisms such as:

1. Elastic Scattering: Also known as Thomson scattering or Rayleigh scattering, it occurs when the energy of the scattered particle or wave remains unchanged after the collision. In the case of electromagnetic radiation (e.g., light), this results in a change of direction without any loss of energy.
2. Inelastic Scattering: This type of scattering involves an exchange of energy between the scattered particle and the target medium, leading to a change in both direction and energy of the scattered particle or wave. An example is Compton scattering, where high-energy photons (e.g., X-rays or gamma rays) interact with charged particles (usually electrons), resulting in a decrease in photon energy and an increase in electron kinetic energy.
3. Coherent Scattering: In this process, the scattered radiation maintains its phase relationship with the incident radiation, leading to constructive and destructive interference patterns. An example is Bragg scattering, which occurs when X-rays interact with a crystal lattice, resulting in diffraction patterns that reveal information about the crystal structure.

In medical contexts, radiation scattering can have both beneficial and harmful effects. For instance, in diagnostic imaging techniques like computed tomography (CT) scans, radiation scattering contributes to image noise and reduces contrast resolution. However, in radiation therapy for cancer treatment, controlled scattering of therapeutic radiation beams can help ensure that the tumor receives a uniform dose while minimizing exposure to healthy tissues.

Poloxalene is not a medical term, but a chemical compound. It's an ether used as a non-ionic surfactant and emulsifying agent in the pharmaceutical industry. Poloxalene is also known for its ability to reduce the severity of bloat (gas distention) in animals, particularly in ruminants like cows, when included in their feed. However, it's not typically used as a human medication.

Secondary protein structure refers to the local spatial arrangement of amino acid chains in a protein, typically described as regular repeating patterns held together by hydrogen bonds. The two most common types of secondary structures are the alpha-helix (α-helix) and the beta-pleated sheet (β-sheet). In an α-helix, the polypeptide chain twists around itself in a helical shape, with each backbone atom forming a hydrogen bond with the fourth amino acid residue along the chain. This forms a rigid rod-like structure that is resistant to bending or twisting forces. In β-sheets, adjacent segments of the polypeptide chain run parallel or antiparallel to each other and are connected by hydrogen bonds, forming a pleated sheet-like arrangement. These secondary structures provide the foundation for the formation of tertiary and quaternary protein structures, which determine the overall three-dimensional shape and function of the protein.

Fluorescence spectrometry is a type of analytical technique used to investigate the fluorescent properties of a sample. It involves the measurement of the intensity of light emitted by a substance when it absorbs light at a specific wavelength and then re-emits it at a longer wavelength. This process, known as fluorescence, occurs because the absorbed energy excites electrons in the molecules of the substance to higher energy states, and when these electrons return to their ground state, they release the excess energy as light.

Fluorescence spectrometry typically measures the emission spectrum of a sample, which is a plot of the intensity of emitted light versus the wavelength of emission. This technique can be used to identify and quantify the presence of specific fluorescent molecules in a sample, as well as to study their photophysical properties.

Fluorescence spectrometry has many applications in fields such as biochemistry, environmental science, and materials science. For example, it can be used to detect and measure the concentration of pollutants in water samples, to analyze the composition of complex biological mixtures, or to study the properties of fluorescent nanomaterials.

Phospholipids are a major class of lipids that consist of a hydrophilic (water-attracting) head and two hydrophobic (water-repelling) tails. The head is composed of a phosphate group, which is often bound to an organic molecule such as choline, ethanolamine, serine or inositol. The tails are made up of two fatty acid chains.

Phospholipids are a key component of cell membranes and play a crucial role in maintaining the structural integrity and function of the cell. They form a lipid bilayer, with the hydrophilic heads facing outwards and the hydrophobic tails facing inwards, creating a barrier that separates the interior of the cell from the outside environment.

Phospholipids are also involved in various cellular processes such as signal transduction, intracellular trafficking, and protein function regulation. Additionally, they serve as emulsifiers in the digestive system, helping to break down fats in the diet.

Hydrogen-ion concentration, also known as pH, is a measure of the acidity or basicity of a solution. It is defined as the negative logarithm (to the base 10) of the hydrogen ion activity in a solution. The standard unit of measurement is the pH unit. A pH of 7 is neutral, less than 7 is acidic, and greater than 7 is basic.

In medical terms, hydrogen-ion concentration is important for maintaining homeostasis within the body. For example, in the stomach, a high hydrogen-ion concentration (low pH) is necessary for the digestion of food. However, in other parts of the body such as blood, a high hydrogen-ion concentration can be harmful and lead to acidosis. Conversely, a low hydrogen-ion concentration (high pH) in the blood can lead to alkalosis. Both acidosis and alkalosis can have serious consequences on various organ systems if not corrected.

Solvents, in a medical context, are substances that are capable of dissolving or dispersing other materials, often used in the preparation of medications and solutions. They are commonly organic chemicals that can liquefy various substances, making it possible to administer them in different forms, such as oral solutions, topical creams, or injectable drugs.

However, it is essential to recognize that solvents may pose health risks if mishandled or misused, particularly when they contain volatile organic compounds (VOCs). Prolonged exposure to these VOCs can lead to adverse health effects, including respiratory issues, neurological damage, and even cancer. Therefore, it is crucial to handle solvents with care and follow safety guidelines to minimize potential health hazards.

Colipases are small protein enzymes that activate and work together with pancreatic lipases to digest dietary fats in the small intestine. They are produced by the pancreas and secreted into the duodenum as part of the pancreatic juice. Colipases help to stabilize and orient the lipase enzyme on the surface of fat droplets, allowing it to efficiently hydrolyze triacylglycerols into monoacylglycerols, free fatty acids, and glycerol. This process is crucial for the absorption of dietary fats in the human body.

Liposomes are artificially prepared, small, spherical vesicles composed of one or more lipid bilayers that enclose an aqueous compartment. They can encapsulate both hydrophilic and hydrophobic drugs, making them useful for drug delivery applications in the medical field. The lipid bilayer structure of liposomes is similar to that of biological membranes, which allows them to merge with and deliver their contents into cells. This property makes liposomes a valuable tool in delivering drugs directly to targeted sites within the body, improving drug efficacy while minimizing side effects.

A lipid bilayer is a thin membrane made up of two layers of lipid molecules, primarily phospholipids. The hydrophilic (water-loving) heads of the lipids face outwards, coming into contact with watery environments on both sides, while the hydrophobic (water-fearing) tails point inward, away from the aqueous surroundings. This unique structure allows lipid bilayers to form a stable barrier that controls the movement of molecules and ions in and out of cells and organelles, thus playing a crucial role in maintaining cellular compartmentalization and homeostasis.

Hydrophobic interactions: These are the interactions that occur between non-polar molecules or groups of atoms in an aqueous environment, leading to their association or aggregation. The term "hydrophobic" means "water-fearing" and describes the tendency of non-polar substances to repel water. When non-polar molecules or groups are placed in water, they tend to clump together to minimize contact with the polar water molecules. These interactions are primarily driven by the entropy increase of the system as a whole, rather than energy minimization. Hydrophobic interactions play crucial roles in various biological processes, such as protein folding, membrane formation, and molecular self-assembly.

Hydrophilic interactions: These are the interactions that occur between polar molecules or groups of atoms and water molecules. The term "hydrophilic" means "water-loving" and describes the attraction of polar substances to water. When polar molecules or groups are placed in water, they can form hydrogen bonds with the surrounding water molecules, which helps solvate them. Hydrophilic interactions contribute to the stability and functionality of various biological systems, such as protein structure, ion transport across membranes, and enzyme catalysis.

Lysophosphatidylcholines (LPCs) are a type of glycerophospholipids, which are major components of cell membranes. They are formed by the hydrolysis of phosphatidylcholines, another type of glycerophospholipids, catalyzed by the enzyme phospholipase A2. LPCs contain a single fatty acid chain attached to a glycerol backbone and a choline headgroup.

In medical terms, LPCs have been implicated in various physiological and pathological processes, such as cell signaling, membrane remodeling, and inflammation. Elevated levels of LPCs have been found in several diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. They can also serve as biomarkers for the diagnosis and prognosis of these conditions.

Nanoparticles are defined in the field of medicine as tiny particles that have at least one dimension between 1 to 100 nanometers (nm). They are increasingly being used in various medical applications such as drug delivery, diagnostics, and therapeutics. Due to their small size, nanoparticles can penetrate cells, tissues, and organs more efficiently than larger particles, making them ideal for targeted drug delivery and imaging.

Nanoparticles can be made from a variety of materials including metals, polymers, lipids, and dendrimers. The physical and chemical properties of nanoparticles, such as size, shape, charge, and surface chemistry, can greatly affect their behavior in biological systems and their potential medical applications.

It is important to note that the use of nanoparticles in medicine is still a relatively new field, and there are ongoing studies to better understand their safety and efficacy.

Chitosan is a complex carbohydrate that is derived from the exoskeletons of crustaceans, such as shrimp and crabs. It is made up of chains of N-acetyl-d-glucosamine and d-glucosamine units. Chitosan has been studied for its potential medical and health benefits, including its ability to lower cholesterol levels, promote weight loss, and help control blood sugar levels. It is also used in wound care products due to its antibacterial and absorbent properties. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines.

Pharmaceutical chemistry is a branch of chemistry that deals with the design, synthesis, and development of chemical entities used as medications. It involves the study of drugs' physical, chemical, and biological properties, as well as their interactions with living organisms. This field also encompasses understanding the absorption, distribution, metabolism, and excretion (ADME) of drugs in the body, which are critical factors in drug design and development. Pharmaceutical chemists often work closely with biologists, medical professionals, and engineers to develop new medications and improve existing ones.

In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."

1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.

2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.

3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.

4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).

Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.

Taurocholic acid is a bile salt, which is a type of organic compound that plays a crucial role in the digestion and absorption of fats and fat-soluble vitamins in the small intestine. It is formed in the liver by conjugation of cholic acid with taurine, an amino sulfonic acid.

Taurocholic acid has a detergent-like effect on the lipids in our food, helping to break them down into smaller molecules that can be absorbed through the intestinal wall and transported to other parts of the body for energy production or storage. It also helps to maintain the flow of bile from the liver to the gallbladder and small intestine, where it is stored until needed for digestion.

Abnormal levels of taurocholic acid in the body have been linked to various health conditions, including gallstones, liver disease, and gastrointestinal disorders. Therefore, it is important to maintain a healthy balance of bile salts, including taurocholic acid, for optimal digestive function.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

Nanospheres are defined in the medical context as tiny, spherical particles that have a diameter in the nanometer range (typically between 1 to 1000 nm). They can be made up of various materials such as polymers, lipids, metals or ceramics. Nanospheres have unique properties due to their small size and large surface area, making them useful for a variety of medical applications including drug delivery, diagnostic imaging, and tissue engineering.

In the field of drug delivery, nanospheres can be used to encapsulate drugs and deliver them to specific sites in the body, improving the efficacy and safety of treatments. They can also be designed to target certain cell types or release their cargo in response to specific stimuli. Additionally, nanospheres can be used as contrast agents for medical imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT).

Overall, nanospheres are a promising tool in the development of new medical technologies and therapies.

Bile acids and salts are naturally occurring steroidal compounds that play a crucial role in the digestion and absorption of lipids (fats) in the body. They are produced in the liver from cholesterol and then conjugated with glycine or taurine to form bile acids, which are subsequently converted into bile salts by the addition of a sodium or potassium ion.

Bile acids and salts are stored in the gallbladder and released into the small intestine during digestion, where they help emulsify fats, allowing them to be broken down into smaller molecules that can be absorbed by the body. They also aid in the elimination of waste products from the liver and help regulate cholesterol metabolism.

Abnormalities in bile acid synthesis or transport can lead to various medical conditions, such as cholestatic liver diseases, gallstones, and diarrhea. Therefore, understanding the role of bile acids and salts in the body is essential for diagnosing and treating these disorders.

Artificial membranes are synthetic or man-made materials that possess properties similar to natural biological membranes, such as selective permeability and barrier functions. These membranes can be designed to control the movement of molecules, ions, or cells across them, making them useful in various medical and biotechnological applications.

Examples of artificial membranes include:

1. Dialysis membranes: Used in hemodialysis for patients with renal failure, these semi-permeable membranes filter waste products and excess fluids from the blood while retaining essential proteins and cells.
2. Hemofiltration membranes: Utilized in extracorporeal circuits to remove larger molecules, such as cytokines or inflammatory mediators, from the blood during critical illnesses or sepsis.
3. Drug delivery systems: Artificial membranes can be used to encapsulate drugs, allowing for controlled release and targeted drug delivery in specific tissues or cells.
4. Tissue engineering: Synthetic membranes serve as scaffolds for cell growth and tissue regeneration, guiding the formation of new functional tissues.
5. Biosensors: Artificial membranes can be integrated into biosensing devices to selectively detect and quantify biomolecules, such as proteins or nucleic acids, in diagnostic applications.
6. Microfluidics: Artificial membranes are used in microfluidic systems for lab-on-a-chip applications, enabling the manipulation and analysis of small volumes of fluids for various medical and biological purposes.

Molecular models are three-dimensional representations of molecular structures that are used in the field of molecular biology and chemistry to visualize and understand the spatial arrangement of atoms and bonds within a molecule. These models can be physical or computer-generated and allow researchers to study the shape, size, and behavior of molecules, which is crucial for understanding their function and interactions with other molecules.

Physical molecular models are often made up of balls (representing atoms) connected by rods or sticks (representing bonds). These models can be constructed manually using materials such as plastic or wooden balls and rods, or they can be created using 3D printing technology.

Computer-generated molecular models, on the other hand, are created using specialized software that allows researchers to visualize and manipulate molecular structures in three dimensions. These models can be used to simulate molecular interactions, predict molecular behavior, and design new drugs or chemicals with specific properties. Overall, molecular models play a critical role in advancing our understanding of molecular structures and their functions.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

This type of micelle is known as a normal-phase micelle (oil-in-water micelle). Inverse micelles have the head groups at the ... Micelles form only when the concentration of surfactant is greater than the critical micelle concentration (CMC), and the ... The formation of micelles can be understood using thermodynamics: Micelles can form spontaneously because of a balance between ... Micelles may also have important roles in chemical reactions. Micellar chemistry uses the interior of micelles to harbor ...
Micelles only form above critical micelle temperature. For example, the value of CMC for sodium dodecyl sulfate in water ( ... The CMC is the concentration of surfactants in the bulk at which micelles start forming. The word bulk is important because ... Upon reaching CMC, any further addition of surfactants will just increase the number of micelles (in the ideal case). According ... Phillips J. The energetics of micelle formation. Transactions of the Faraday Society 1955;51:561-9 Mukerjee, P.; Mysels, K. J. ...
Newkome GR, Yao Z, Baker GR, Gupta VK (1985). "Micelles Part 1. Cascade molecules: a new approach to micelles, A-arborol". J. ... Newkome GR, Yao Z, Baker GR, Gupta VK (1985). "Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol ... The use of dendrimers as unimolecular micelles was proposed by Newkome in 1985. This analogy highlighted the utility of ... Liu M, Kono K, Fréchet JM (March 2000). "Water-soluble dendritic unimolecular micelles: their potential as drug delivery agents ...
Multicompartment polymer micelles. Attempts to Mimic Biomembrane Processes: Synthetic and natural receptors in molecular ...
The second type is noticeably larger than the first and has been termed 'super micelles'. Unfortunately, the structure of the ... In the case of spherical Janus micelles having hemispheres of polystyrene (PS) and poly(methyl methacrylate) (PMMA), ... "Janus Micelles" (PDF). Macromolecules. 34 (4): 1069-1075. Bibcode:2001MaMol..34.1069E. doi:10.1021/ma000670p.{{cite journal}}: ...
Bates, Frank S.; Davis, H. Ted; Won, You-Yeon (1999-02-12). "Giant Wormlike Rubber Micelles". Science. 283 (5404): 960-963. ... "Giant Wormlike Rubber Micelles", Science 283, 960 (1999). F.S. Bates, G.H. Fredrickson, D. Hucul, S.F. Hahn "PCHE-based ... "Toughening of Epoxies with Block Copolymer Micelles of Wormlike Morphology". Macromolecules. 43 (17): 7238-7243. Bibcode: ...
Reverse micelles as hosts for proteins and small molecules; P.P. Luisi, M. Giomini, M.P. Pileni, B. Robinson; Biochem. Biophys ... 947, 209-216, (1988). Reverse micelles : a microreactors; M.P. Pileni; J. Phys.Chem. 97, 6961-6974 (1993). Nanosized Particles ...
"Micelle". Google Scholar. 2006. Retrieved 18 October 2014. "TWAS". TWAS. 2015. Retrieved 23 January 2015. "APAM". APAM. 2014. ... Sood has also experimented with soft condensed matter like micelle composed viscoelastic gels which establish a deterministic ...
Micelles, Membranes, Microemulsions, and Monolayers. Partially Ordered Systems. Springer. pp. 1-104. doi:10.1007/978-1-4613- ... and on the self-assembly theory of micelles, surfactant monolayers, and biological membranes. During a sabbatical year in 1998- ...
... an aggregation number is a description of the number of molecules present in a micelle once the critical micelle concentration ... Micelles: theoretical and applied aspects. Springer Science & Business Media, 1992. N.E. Olesen. Journal of Colloid and ... In more detail, it has been defined as the average number of surfactant monomers in a spherical micelle. The aggregation number ... "What can isothermal titration microcalorimetry experiments tell us about the self‐organization of surfactants into micelles?." ...
"Glycation Reactions of Casein Micelles". Journal of Agricultural and Food Chemistry. 64 (14): 2953-2961. doi:10.1021/acs.jafc. ...
Tanford, Charles (May 1974). "Thermodynamics of Micelle Formation: Prediction of Micelle Size and Size Distribution". ... Micelles are spheres with a hydrophobic core formed by the non-polar tail of wetting solution molecules and are surrounded by a ... Not until Debye published his original hypothesis in 1949 did he described the reason of micelle formation and the existence of ... At this point, the surface tension is maximally lowered and is termed as the critical micelle concentration (CMC). The lower ...
Micelle; Spaulding, Paul M.; Velazco, Marcelo; Weksler, John R.; Wible, Andrea L.; Cirranello, A. L. (8 February 2013). "The ...
Micelle; Spaulding, Paul M.; Velazco, Marcelo; Weksler, John r.; Wible, Andrea L.; Cirranello, A. L. (8 February 2013). "The ...
"Micelle Edwards". University of Iowa Department of Intercollegiate Athletics. Retrieved 5 Jun 2014. "Storm's Edwards calls it ...
Micelle; Velazco, Paul M.; Weksler, Marcelo; Wible, John R.; Cirranello, Andrea L. (8 February 2013). "The Placental Mammal ...
Haydel, Micelle; Scott, Dulebohn (2021). "Blunt Head Trauma". StatPearls. PMID 28613521. Retrieved 11 December 2018. Nickson, ...
Micelle; Spaulding, Paul M.; Velazco, Marcelo; Weksler, John r.; Wible, Andrea L.; Cirranello, A. L. (8 February 2013). "The ...
Micelle; Velazco, Paul M.; Weksler, Marcelo; Wible, John r.; Cirranello, Andrea L. (8 February 2013). "The Placental Mammal ...
His papers and inventions introduced nanogels, cross-linked polymeric micelles, and high-capacity poly(2-oxazoline) micelles ... "The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers ... Batrakova, E. V.; Han, H. Y.; Miller, D. W.; Kabanov, A. V. (1998). "Effects of pluronic P85 unimers and micelles on drug ... In late the late 1980s Kabanov published seminal work on the use of polymeric micelles as a nanoparticle delivery platform for ...
His paper, "Micelles of Delivery of Nitric Oxide", was published in the Journal of the American Chemical Society in September ... Jo, Yun Suk (September 18, 2009). "Micelles for Delivery of Nitric Oxide". Journal of the American Chemical Society. 131 (40): ...
Haydel, Micelle J.; Preston, Charles A.; Mills, Trevor J.; Luber, Samuel; Blaudeau, Erick; DeBlieux, Peter M.C. (2000). " ...
1990). "Amino acids in AOT reversed micelles. 2. The hydrophobic effect and hydrogen bonding as driving forces for interfacial ... measured the partitioning of 14 radiolabeled amino acids using sodium dodecyl sulfate (SDS) micelles. Also, amino acid side ...
... micelles} }} is number concentration of micelles (number of micelles per unit volume), and N A {\displaystyle N_{\mathrm {A ... Excess surfactant creates micelles in the water. Small amounts of monomer diffuse through the water to the micelle. A water- ... Monomer in the micelle quickly polymerizes and the growing chain terminates. At this point the monomer-swollen micelle has ... Those micelles that did not encounter a radical during the earlier stage of conversion begin to disappear, losing their monomer ...
Once solubilized by encapsulation in either a hydrophobic interior micelle or a hydrophilic exterior micelle, the QDs can be ... which will spontaneously form micellular structures at its critical micelle concentration (CMC). The critical micelle ... These micelles can be moved in a magnetic field to create concentration gradients that will influence a cell's processes. Gold ... However, if the PEG chain is too long the micelle will become unstable. It has been observed that a stable hydrogel can only be ...
"Light-induced reversible formation of polymeric micelles". Angewandte Chemie International Edition. 46 (14): 2453-2457. doi: ...
Bandyopadhyaya, Rajdip; Kumar, R.; Gandhi, K. S. (2000). "Simulation of precipitation reactions in reverse micelles". Langmuir ...
Kaler is coeditor of the book Giant Micelles and is author or coauthor of more than 200 papers. He holds 10 U.S. patents. Kaler ... Examples are liquid crystals, microemulsions and micelles, some polymeric solutions, vesicles, emulsions, and protein solutions ... Kaler, Eric William (1982). Surfactant Microstructures (Microemulsions, Micelles) (Ph.D. thesis). University of Minnesota. OCLC ...
Merocyanine dyes in cationic and anionic micelles". Journal of Organic Chemistry, 44:3252, 1979. Amaresh Mishra, et al.: " ...
"Rheology and structure of worm-like micelles". Current Opinion in Colloid & Interface Science. 6 (5-6): 451-456. doi:10.1016/ ...
This type of micelle is known as a normal-phase micelle (oil-in-water micelle). Inverse micelles have the head groups at the ... Micelles form only when the concentration of surfactant is greater than the critical micelle concentration (CMC), and the ... The formation of micelles can be understood using thermodynamics: Micelles can form spontaneously because of a balance between ... Micelles may also have important roles in chemical reactions. Micellar chemistry uses the interior of micelles to harbor ...
The temperature-dependence of PS80 micelle growth kinetics is quantified by SANS in the presence of m-cresol. The monotonic ... The addition of m-cresol to PS80 solutions leads to solution turbidity and irreversibly alters PS80 micelle morphology. This ... Gilbert, P. , Zhang, Z. , Qian, K. , Allen, D. , Wagner, N. and Liu, Y. (2021), Preservative Induced Polysorbate 80 Micelle ... which highlights the essential role that micelle growth kinetics plays in preservative-surfactant interactions. ...
Helix curvature is significantly less than predicted based on the native micelle shape, indicating a deformation of the micelle ... Structure and dynamics of micelle-bound human alpha-synuclein. Ulmer, T.S., Bax, A., Cole, N.B., Nussbaum, R.L.. (2005) J Biol ... Here, the structure and dynamics of micelle-bound aS are reported. Val3-Val37 and Lys45-Thr92 form curved alpha-helices, ... Here, the structure and dynamics of micelle-bound aS are reported. Val3-Val37 and Lys45-Thr92 form curved alpha-helices, ...
... and surface-functionalized worm-like block copolymer micelles as drug delivery vehicles. The polyether-based diblock terpolymer ... Core-Cross-linked Fluorescent Worm-Like Micelles for Glucose-Mediated Drug Delivery Biomacromolecules. 2021 Apr 12;22(4):1458- ... Furthermore, we covalently attached glucose to the allyl end groups present on the surface of the micelles to investigate ... and surface-functionalized worm-like block copolymer micelles as drug delivery vehicles. The polyether-based diblock terpolymer ...
Multicompartment micelles from blends of terpolymers†‡ Jean-François Gohy,*a Nathalie Lefèvre,a Cécile DHaese,a Stephanie ... to lead to micelles containing a core formed of poly(VDF-ter-HFP) segments and TFMA/2VP hydrogen-bonded complexes, and a corona ... Multicompartment micelles from blends of terpolymers J. Gohy, N. Lefèvre, C. DHaese, S. Hoeppener, U. S. Schubert, G. Kostov ...
... rather than buried deeply within the micelle. This suggestion is supported by the selective broadening of micelle-bound ... The cyclotides from the different subfamilies exhibited clearly different binding orientations at the micelle surface. ... bound to dodecylphosphocholine micelles, using NMR spectroscopy in the presence and absence of 5- and 16-doxylstearate ... Solution structure of micelle-bound kalata B2. *PDB DOI: https://doi.org/10.2210/pdb2KCH/pdb ...
Keywords: sodium conjugated linoleate, self-assembly, micelle Fig.1 The cryo-TEM image of the SCL-micelles (A) and the TEM ... and spherical SCL micelles were self-assembled in pH 13 at the concentration of 3 mmol·L-1, and then the SCL micelles were ... See Micelles Clearly. Bei Wei, Ye Fan, Chao Chen, Yongchun Pan, Biao Jiang, Lingyu Bao, Meng Zhu, Yun Fang*. The Key Laboratory ... Abstract: Small spherical micelles may be the self-assemblies of surfactants with the simplest morphology, which has become the ...
The IUPAC Compendium of Chemical Terminology
Citation: copolymer micelle in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied ...
Amphiphilic protein micelles for targeted in vivo imaging on Materials Today - the gateway for characterization features. ... Home » Characterization » Features » Amphiphilic protein micelles for targeted in vivo imaging Amphiphilic protein micelles for ...
Microrheology of giant-micelle solutions. F. Cardinaux1, L. Cipelletti2, F. Scheffold1 and P. Schurtenberger1 ... Brownian motion of particles embedded in a solution of giant micelles Eur. Phys. J. E (2002) 8: 431-436. ... Synergistic effects in mixed wormlike micelles of dimeric and single-chain cationic surfactants at high ionic strength Eur. ... Under the chosen conditions these surfactants self-assemble to form giant polymer-like micelles, resulting in a strongly ...
Shop for Bioderma Sebium H2O Purifying Cleansing Micelle Solution from Singapores trusted grocery retailer. FairPrice offers a ... The micelles contained in its formula ensure impurities are removed while respecting the cutaneous balance (soap-free, ...
Taking advantage of CTAB micelles for the simultaneous electrochemical quantification of diclofenac and acetaminophen in ... Taking advantage of CTAB micelles for the simultaneous electrochemical quantification of diclofenac and acetaminophen in ...
Surface active agent can make the liquid CO2 gel by forming wormlike micelle or cylinder micelles structure. The cylinder ... A New Liquid CO2 Based Gel Fracturing Fluid with Cylinder Micelles Structure Yongjun Lu; Yongjun Lu ... "A New Liquid CO2 Based Gel Fracturing Fluid with Cylinder Micelles Structure." Paper presented at the SPE Asia Pacific ... micelles enhance the viscosity through entanglement inter-actions above a critical concentration. ...
MicroemulsionsThe phase behavioralkyl chain lengthssurfactantMicellesnitratelyotropicpropylammoniumLyotropic Liquid Crystals ... Micelles and single-phase microemulsions were all found to form at alkyl chain lengths from dodecyl to octadecyl, and lyotropic ... Propylammonium Nitrate as a Solvent for Amphiphile Self-Assembly into Micelles, Lyotropic Liquid Crystals, and Microemulsions. ...
chemiluminescence in micelle solutions - a model system for cypridina bioluminescence Tetrahedron Letters 10(49): 4299-4302. ... Cypridina bio luminescence part 7 chemi luminescence in micelle solutions a model system for cypridina bio luminescence. Goto, ...
The micelle-incorporated sulfonic acid groups mimic the function of biological membrane proteins that deftly control the ... 关键字:1. biomimicking Micelles, hydrogel, fluorescent, electrically responsive, self-healing, aggregation-induced emission. 论文来源: ... Fluorescent, electrically responsive and ultratough self-healing hydrogels via bioinspired all-in-one hierarchical micelles ... electrically responsive and ultratough self-healing hydrogels via aqueous self-assembly of polyelectrolyte-surfactant micelles ...
This suggests stabilization of the polar dispersed phase in polar regions of the micelle. ... ultrafast dynamics, microemulsions, monosubstituted benzenes, dodecyltrimethylammonium bromide (DTAB), aqueous micelles, ... aqueous micelles. Langmuir, 21 (2005). pp. 1238-1243. ISSN 0743-7463 (http://dx.doi.org/10.1021/la047599r) ...
Growth of gold nanorods is investigated in the presence of ascorbic acid in an aqueous mixed micelle solution of ... in the Crystallization of Gold Nanorods within CTAB/TOAB Micelles. ...
Be the first to review "Bioderma Crealine H2O Micelle Oplossing 2 x 500ml" Cancel reply. Your email address will not be ... Bioderma Crealine H2O Micelle Solution, 2 flessen (500 ml per stuk) van Bioderma. ... Bioderma Crealine H2O Micelle Solution, 2 flessen (500 ml per stuk) van Bioderma ...
Switchable Supramolecular Organization of Structurally Defined Micelles Based on an Amphiphilic Fullerene. S. Burghardt, A. ... Switchable Supramolecular Organization of Structurally Defined Micelles Based on an Amphiphilic Fullerene ... Switchable Supramolecular Organization of Structurally Defined Micelles Based on an Amphiphilic Fullerene ...
T1 - Micelle and Gel Formation in a Poly (ethylene oxide)/ Poly (propylene oxide)/ Poly (ethylene oxide) Triblock Copolymer in ... Micelle and Gel Formation in a Poly (ethylene oxide)/ Poly (propylene oxide)/ Poly (ethylene oxide) Triblock Copolymer in Water ... Micelle and Gel Formation in a Poly (ethylene oxide)/ Poly (propylene oxide)/ Poly (ethylene oxide) Triblock Copolymer in Water ... Micelle and Gel Formation in a Poly (ethylene oxide)/ Poly (propylene oxide)/ Poly (ethylene oxide) Triblock Copolymer in Water ...
Worm-like micelles of CTAB and sodium salicylate under turbulent flow. In: Langmuir. 2008 ; Vol. 24, No. 24. pp. 13875-13879. ... Worm-like micelles of CTAB and sodium salicylate under turbulent flow. Roberta K. Rodrigues, Marcelo A. Da Silva, Edvaldo ... Worm-like micelles of CTAB and sodium salicylate under turbulent flow. / Rodrigues, Roberta K.; Da Silva, Marcelo A.; Sabadini ... Rodrigues RK, Da Silva MA, Sabadini E. Worm-like micelles of CTAB and sodium salicylate under turbulent flow. Langmuir. 2008 ...
An investigation of the synthesis and properties of nano crystalline Y2O3: Eu3+ (prepared using micelle-based precursors).. ... An investigation of the synthesis and properties of nano crystalline Y2O3: Eu3+ (prepared using micelle-based precursors) ( ...
Atomic Force Microscopy Force Mapping Analysis of an Adsorbed Surfactant above and below the Critical Micelle Concentration. ... Atomic Force Microscopy Force Mapping Analysis of an Adsorbed Surfactant above and below the Critical Micelle Concentration. In ... Atomic Force Microscopy Force Mapping Analysis of an Adsorbed Surfactant above and below the Critical Micelle Concentration. / ... Atomic Force Microscopy Force Mapping Analysis of an Adsorbed Surfactant above and below the Critical Micelle Concentration. ...
Deposition of gadolinium onto the shell structure of micelles for integrated magnetic resonance imaging and robust drug ... Deposition of gadolinium onto the shell structure of micelles for integrated magnetic resonance imaging and robust drug ...
As far as we know, the present study is the first time to demonstrate the potency of both fisetin and fisetin micelles inducing ... Multiple lines of evidence indicated that fisetin and fisetin micelles induce apoptosis in ovarian cancer cells in a dose- ... In addition, the efficacy of fisetin and fisetin-micelles in vivo was determined by using immunocompromised mice. Apoptosis was ... Further studies will be needed to validate the therapeutic potential of fisetin and fisetin micelles in ovarian cancer ...
Spherical micelles are favored entropically, as they are the most stable self assembly. This is referred to as the micelles " ... Given the negative charge of the exterior micelle head, the individual micelles repel from one another. Energetically bouncing ... The micelle nanoparticle is composed of lipids. Each individual lipid has two components, a head and a tail. Each end of the ... A micelle is one to four nanometers in diameter. For a point of reference, a human hair is about 80,000 nanometers. ...
  • Polymers with high molecular weight and worm-like micelles are drag-reducing agents under turbulent flow. (bath.ac.uk)
  • However, in contrast to the polymeric systems, the worm-like micelles do not undergo mechanical degradation due to the turbulence, because their macromolecular structure can be spontaneously restored. (bath.ac.uk)
  • This very favorable property, together with their drag-reduction capability, offer the possibility to use such worm-like micelles in heating and cooling systems to recirculate water while expending less energy. (bath.ac.uk)
  • The formation, growth, and stability of worm-like micelles formed by cetyltrimethylammonium bromide (CTAB) and sodium salicylate(NaSal) were investigated using the self-fluorescence of salicylate ions and the ability of the giant micelles to promote hydrodynamic drag reduction under turbulent flow. (bath.ac.uk)
  • Contrast variation in small-angle neutron scattering enables us to focus on one compartment of the worm-like micelles. (uni-bayreuth.de)
  • Under the chosen conditions these surfactants self-assemble to form giant polymer-like micelles, resulting in a strongly viscoelastic liquid. (edpsciences.org)
  • Polymer micelles were recognized as an effective carrier system for drug encapsulation, and are now studied as a vehicle for oral delivery of insoluble compounds. (huji.ac.il)
  • Drug loading of polymer micelles can have a profound effect on their particle size and morphology as well as their physicochemical properties. (bvsalud.org)
  • Furthermore, curcumin molecules can be exchanged between polymer micelles and bile colloids , an important prerequisite for their uptake. (bvsalud.org)
  • Finally, increased loading of the polymer micelles with curcumin resulted in a larger number of vesicles as taurocholateâ through coordination with Curâ is less available to form nanoparticles with the lipids . (bvsalud.org)
  • Addition of a pH-regulating citrate buffer accelerates micelle aggregation kinetics. (nist.gov)
  • As the cyclodextrin concentration increases, this equilibrium leads to the shifting of the multiple equilibria involving micelles of successive aggregation numbers toward those of smaller dimensions and to the decrease of the average intermicellar distance. (ua.pt)
  • The structural characterization, obtained with small-angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 ± 2 and the two micellar axes of about 52 and 26 Å. (cnr.it)
  • The shape and size of a micelle are a function of the molecular geometry of its surfactant molecules and solution conditions such as surfactant concentration, temperature, pH, and ionic strength. (wikipedia.org)
  • The size of a micelle ranges from 2 nm to 20 nm. (pediaa.com)
  • Holdings: Critical Concentrations and Role of Ascorbic Acid (Vitamine C) in the Crystallization of Gold Nanorods within CTAB/TOAB Micelles. (villanova.edu)
  • Growth of gold nanorods is investigated in the presence of ascorbic acid in an aqueous mixed micelle solution of hexadecyltrimethyl ammonium bromide (CTAB) and tetraoctyl ammonium bromide (TOAB) through photochemical reduction of HAuCl4·3H2O using 300 nm Hg lamps. (villanova.edu)
  • Detailed diagrams were obtained for different ratios of Sal and CTAB, which revealed transitions associated with the thermal stability of giant micelles under turbulent flow. (bath.ac.uk)
  • The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. (ac.rs)
  • copolymer micelle' in IUPAC Compendium of Chemical Terminology , 3rd ed. (iupac.org)
  • A micelle (/maɪˈsɛl/) or micella (/maɪˈsɛlə/) (plural micelles or micellae, respectively) is an aggregate (or supramolecular assembly) of surfactant amphipathic lipid molecules dispersed in a liquid, forming a colloidal suspension (also known as associated colloidal system). (wikipedia.org)
  • In water, the hydrophilic "heads" of surfactant molecules are always in contact with the solvent, regardless of whether the surfactants exist as monomers or as part of a micelle. (wikipedia.org)
  • However, the lipophilic "tails" of surfactant molecules have less contact with water when they are part of a micelle-this being the basis for the energetic drive for micelle formation. (wikipedia.org)
  • In a micelle, the hydrophobic tails of several surfactant molecules assemble into an oil-like core, the most stable form of which having no contact with water. (wikipedia.org)
  • In water, the hydrophobic effect is the driving force for micelle formation, despite the fact that assembling surfactant molecules is unfavorable in terms of both enthalpy and entropy of the system. (wikipedia.org)
  • On the whole, the experimental results point to the adsorption of methylated cyclodextrins on the surface of the formed decanoate micelles and are consonant with the existence of an equilibrium between the molecules in aqueous solution and those adsorbed by the micelles. (ua.pt)
  • For example micelles form which consist of several clustered surfactant molecules that shield their non-polar chains from the surrounding aqueous phase with their polar head groups (see figure 3 ). (dataphysics-instruments.com)
  • The main difference between chylomicrons and micelles is that chylomicrons are lipoproteins having a core of t riglycerides and cholesterols and a coat made of apolipoproteins and phospholipids , whereas micelles are globules of lipid molecules that are arranged in a spherical form in an aqueous solution. (pediaa.com)
  • Micelles are globules of lipid molecules that are arranged in a spherical form in an aqueous solution. (pediaa.com)
  • We use self-assembly, driven by interactions between nanoscopic species (micelles, nanoparticles, polymers) in solution and at interfaces to form materials with organized structures from nm to cm. (lu.se)
  • Inspired by the hierarchical structure of fluorescent proteins in jellyfish and biomembranes in nature, herein, a facile and universal all-in-one strategy is demonstrated to construct fluorescent, electrically responsive and ultratough self-healing hydrogels via aqueous self-assembly of polyelectrolyte-surfactant micelles with hierarchical structures and functionality. (polymer.cn)
  • Small-angle neutron scattering is used to study the influence that methylated and unsubstituted cyclodextrins might have on sodium decanoate micelles in D(2)O aqueous solution. (ua.pt)
  • Small spherical micelles may be the self-assemblies of surfactants with the simplest morphology, which has become the fundament to further explore complex amphiphilic systems and life phenomenon. (confex.com)
  • As you can see in Fig.1B, the clearest TEM image of spherical micelles of surfactants by far was obtained successfully, and provided the direct evidence of the micellar diameter indeed twice stretch length of a surfactant hydrophobic chain ( 3-5 nm). (confex.com)
  • Four diblock copolymers, POEGMA-block-poly(N-isopropylacrylamide) (POEGMA-b-PNIPAM), POEGMA-b-poly(N,N-diethylacrylamide) (POEGMA-b-PDEAM), and two examples of POEGMA-b-[PNIPAM-co-poly(pentafluorophenyl acrylate)] (POEGMA-b-(PNIPAM-co-PPFPA)), containing different amounts of activated PFP esters, were found to reversibly self-assemble into well-defined spherical micelles upon cooling in 1-octanol, as evidenced by dynamic light scattering (DLS) and electron microscopy. (edu.au)
  • Micelles composed of ionic surfactants have an electrostatic attraction to the ions that surround them in solution, the latter known as counterions. (wikipedia.org)
  • The formation of micelles is due to the amphiphilic nature of the fatty acids (fatty acids have a hydrophilic head and a hydrophobic tail). (pediaa.com)
  • Impaired micelle formation causes a problem in fat solubilization and subsequent fat malabsorption. (medscape.com)
  • The bacteria deconjugate bile salts, causing failure of micelle formation and subsequent fat malabsorption. (msdmanuals.com)
  • In this study, we address this interface in vitro through a detailed structural characterization of the colloidal assemblies of polymeric micelles based on poly(2-oxazolines) with three different guest loadings with the natural product curcumin (17-52 wt %) in fed- state simulated intestinal fluids (FeSSIF). (bvsalud.org)
  • However we hypothesised that since a reaction that produces an amphiphile can result in the self-assembly of supramolecular structures such as micelles or vesicles 7 , the use of a template self-replication reaction to produce an amphiphile would link self-replication to the formation of such structures. (nature.com)
  • The addition of m-cresol to PS80 solutions leads to solution turbidity and irreversibly alters PS80 micelle morphology. (nist.gov)
  • The morphology of the self- crosslinked SCL micelles was characterized by high-resolution transmission electron microscopy (TEM). (confex.com)
  • By the way, in situ reduction and gold doping-TEM coupling technology is applying to investigate morphology of spherical surfactant micelles in order to further improve the TEM image contrast. (confex.com)
  • The aggregates exhibited an inverted morphology compared to PNIPAM core-POEGMA shell micelles accessible through a thermally triggered self-assembly in water exploiting the lower critical solution temperature (LCST) behaviour of PNIPAM. (edu.au)
  • Inverse micelles have the head groups at the centre with the tails extending out (water-in-oil micelle). (wikipedia.org)
  • In addition to the micelles shown in figure 3 so-called inverse micelles exist which cluster their head groups and orient their chains towards a surrounding non-polar phase. (dataphysics-instruments.com)
  • Micelles form only when the concentration of surfactant is greater than the critical micelle concentration (CMC), and the temperature of the system is greater than the critical micelle temperature, or Krafft temperature. (wikipedia.org)
  • To solve the problems in this paper, sodium conjugated linoleate (SCL), a type polymerizable anionic surfactant was synthesized, and spherical SCL micelles were self-assembled in pH 13 at the concentration of 3 mmol·L -1 , and then the SCL micelles were tethered by moderated UV irradiation to insure its original fragile micellar structure maintained. (confex.com)
  • The cylinder micelles enhance the viscosity through entanglement inter-actions above a critical concentration. (onepetro.org)
  • The critical micelle concentration CMC is the surfactant concentration at and above which micelles are formed. (dataphysics-instruments.com)
  • Furthermore, the formation of micelles happens above the critical micelle concentration. (pediaa.com)
  • In water solution at pH 7.4, PCA self-assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 × 10-7 mol kg-1] as confirmed by fluorescence spectroscopy. (cnr.it)
  • Triazine enhanced LAS transport, and SRA decreased LAS critical micelle concentration (CMC) which reduced LAS monomers available for membrane transport. (cdc.gov)
  • The formation of micelles can be understood using thermodynamics: Micelles can form spontaneously because of a balance between entropy and enthalpy. (wikipedia.org)
  • This relationship contradicts the thermodynamics of micelle formation in solution. (ox.ac.uk)
  • The difficulty filling all the volume of the interior of a bilayer, while accommodating the area per head group forced on the molecule by the hydration of the lipid head group, leads to the formation of the micelle. (wikipedia.org)
  • These highly mobile, spontaneously formed clusters came to be called micelles, a term borrowed from biology and popularized by G.S. Hartley in his classic book Paraffin Chain Salts: A Study in Micelle Formation. (wikipedia.org)
  • Adding salts to a colloid containing micelles can decrease the strength of electrostatic interactions and lead to the formation of larger ionic micelles. (wikipedia.org)
  • Micelle and Gel Formation in a Poly (ethylene oxide)/ Poly (propylene oxide)/ Poly (ethylene oxide) Triblock Copolymer in Water Solution. (dtu.dk)
  • The minimization of the unfavorable contact between non-polar surfactant chains and the polar solvent compensates the loss of entropy by micelle formation. (dataphysics-instruments.com)
  • Micelle contains fatty acids with a single hydrocarbon chain, facilitating the easy formation of the spherical shape due to the lesser steric hindrance. (pediaa.com)
  • Formation and dissociation processes of gas-phase detergent micelles. (ox.ac.uk)
  • Possibilities of micelle formation exist. (cdc.gov)
  • The micelle-incorporated sulfonic acid groups mimic the function of biological membrane proteins that deftly control the micelle size, leading to electro-responsiveness, enhanced toughness and fluorescence emission. (polymer.cn)
  • Growing interest in micelles to protect membrane complexes during the transition from solution to gas phase prompts a better understanding of their properties. (ox.ac.uk)
  • After crystallization-induced self-assembly of polystyrene-block-polyethylene-block-poly(methyl methacrylate) triblock terpolymers (abbreviated as SEMs = Styrene-Ethylene-Methacrylates) from solution, worm-like core-shell micelles with a patchy corona of polystyrene and poly(methyl methacrylate) were observed by transmission electron microscopy. (uni-bayreuth.de)
  • Micelle gel is a radiochromic hydrogel with the potential to be used as a three dimensional (3D) radiation dosimeter. (edu.au)
  • Micelles represent a molecular assembly, in which the individual components are thermodynamically in equilibrium with monomers of the same species in the surrounding medium. (wikipedia.org)
  • The lack of phospholipids produces unstable micelles that have a toxic effect on the bile ducts, leading to bile duct plugs and biliary obstruction. (medscape.com)
  • The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. (ac.rs)
  • Normally, water-insoluble cholesterol is made water soluble by combining with bile salts and lecithin to form mixed micelles. (msdmanuals.com)
  • To determine the structural basis for the biological activity of the two major subfamilies of cyclotides, we determined the conformation and orientation of kalata B2 (kB2), a Möbius cyclotide, and cycloviolacin O2 (cO2), a bracelet cyclotide, bound to dodecylphosphocholine micelles, using NMR spectroscopy in the presence and absence of 5- and 16-doxylstearate relaxation probes. (rcsb.org)
  • Although it is possible to theoretically infer that micellar diameter is about twice stretch length of a hydrophobic chain length of a surfactant (3-5 nm) and laser light scattering experiment provides some indirect evidence of the particle size, there is a lack of a powerful technique to give direct visualization for characterizing surfactant micelles. (confex.com)
  • Micelle technology reduces the particle size of the carbon structure the charcoal is composed of. (organically-kismet.store)
  • In turn, unsubstituted cyclodextrins are not adsorbed by the decanoate micelles and so are involved in a guest-host equilibrium with the decanoate ion in solution. (ua.pt)
  • Micelle Solution is a cleansing solution for combination or oily skin types. (activecarestore.co.uk)
  • Micelles of polystyrene-block-poly-(2-vinylpyridine) (PS-b-P2VP) in toluene were used as nanoreactors to fabricate FeCl3 in the core domains, and the complex solution was used as an ink to print films with polydimethylsiloxane (PDMS) stamps, different morphologies (porous, dots and stripes patterns) of the FeCl3-loaded micellar films were left onto silicon substrates after printed. (hereon.de)
  • We characterized the properties of monomethoxy polyethylene glycol-poly lactic acid (mPEG-PLA) micelles, and visualized their internalization in mouse small intestine. (huji.ac.il)
  • The authors in this paper developed monomethoxy polyethylene glycol-poly lactic acid (mPEG-PLA) micelles as a drug nanocarrier, and studied the mechanism of uptake across intestinal cells. (huji.ac.il)
  • A typical micelle in water forms an aggregate with the hydrophilic "head" regions in contact with surrounding solvent, sequestering the hydrophobic single-tail regions in the micelle centre. (wikipedia.org)
  • Although the closest counterions partially mask a charged micelle (by up to 92%), the effects of micelle charge affect the structure of the surrounding solvent at appreciable distances from the micelle. (wikipedia.org)
  • Dialysis method, solid dispersion, solvent evaporation, and oil in water emulsion are the predominant methods of preparation of micelles. (pediaa.com)
  • This slow preservative-induced destabilization of PS80 micelles progresses over days or even weeks, which highlights the essential role that micelle growth kinetics plays in preservative-surfactant interactions. (nist.gov)
  • The temperature-dependence of PS80 micelle growth kinetics is quantified by SANS in the presence of m-cresol. (nist.gov)
  • Simplicio J, Schwenzer K, Maenpa F. Kinetics of cyanate and imidazole binding to hemin in micelles. (medscape.com)
  • The self-assembled 2-ureido-4-[1 H ]-pyrimidone (UPy) hydrophobic core containing reversible physical crosslinks embedded in micelles leads to a durable network structure with excellent toughness and self-healing ability. (polymer.cn)
  • In brief, chylomicrons and micelles are fat globules having a hydrophobic core and a hydrophilic coat. (pediaa.com)
  • Moreover, varying parameters like temperature or system composition micelles can also adopt forms other than spherical, such as elongated and worm-like structures. (dataphysics-instruments.com)
  • unstable cluster structure and weak ability to scatter electrons, even if by a combination technique of the advanced electron microscopy with other special sample preparation techniques (cryogenic, freeze fracture, etc), the images of the small micelles are still unclear as presented in Fig.1A. (confex.com)
  • Micelles and single-phase microemulsions were all found to form at alkyl chain lengths from dodecyl to octadecyl, and lyotropic liquid crystals formed with hexadecyl chains or longer. (figshare.com)
  • Here, the structure and dynamics of micelle-bound aS are reported. (rcsb.org)
  • Surface active agent can make the liquid CO 2 gel by forming wormlike micelle or cylinder micelles structure. (onepetro.org)
  • This suggests stabilization of the polar dispersed phase in polar regions of the micelle. (strath.ac.uk)
  • On the outer surface, micelles have polar head groups. (pediaa.com)
  • CICECO Publication » Why Do Methylated and Unsubstituted Cyclodextrins Interact So Differently with Sodium Decanoate Micelles in Water? (ua.pt)
  • We herein report the fabrication of core-crosslinked, fluorescent, and surface-functionalized worm-like block copolymer micelles as drug delivery vehicles. (nih.gov)
  • In addition, the simulations will clarify the stability of the micelles as well as structural fluctuations. (northwestern.edu)
  • This variation in size is due to the variation of the composition in different types of micelles. (pediaa.com)
  • Ionic micelles influence many properties of the mixture, including its electrical conductivity. (wikipedia.org)
  • An investigation of the synthesis and properties of nano crystalline Y2O3: Eu3+ (prepared using micelle-based precursors). (bentham.co.uk)
  • An investigation of the synthesis and properties of nano crystalline Y2O3: Eu3+ (prepared using micelle-based precursors) (Doctoral dissertation). (bentham.co.uk)
  • To explore further the properties of gas-phase micelles, we have performed collision-induced dissociation on them during tandem mass spectrometry. (ox.ac.uk)
  • Since an ideal dosimeter should present water equivalent properties, in this study the water equivalence of two formulations of micelle gel has been investigated by calculating electron density, effective atomic number, fractional interaction probabilities, mass attenuation coefficient. (edu.au)
  • Contrast variation SANS studies using deuterated version of C12EO6 or SDS, or by varying the D2O/H2O ratio of the suspensions (with CapB), allowed focusing only on the structural properties of OCNFs or surfactant micelles. (lu.se)
  • This type of micelle is known as a normal-phase micelle (oil-in-water micelle). (wikipedia.org)
  • Sensibio H2O is de 1Re en het alleen dermatologisch micellair water, perfecte biologische analyse met de huid te presenteren. (marsenchansons.be)
  • This is demonstrated by its ability to stabilise reverse micelles of water in chloroform. (nature.com)
  • It is suggested that methylated cyclodextrins should be more easily adsorbed on the electric double layer of the decanoate micelle-water interface than the unsubstituted cyclodextrins, as the former tend to sample the environment that is most energetically favorable, where the dielectric permittivity is lower than in bulk water and so is closer to those of the methylated cyclodextrins. (ua.pt)
  • Inverted micelles with PNIPAM-co-PPFPA coronae in 1-octanol were shell crosslinked using a diamine and subsequently transferred into water. (edu.au)
  • Micelles self-assemble into spherical shapes in the water. (pediaa.com)
  • Based on the results of this work, micelle gels can be considered as water equivalent dosimeters. (edu.au)
  • By relating the observed micelle morphologies to the various experimentally controllable parameters, large savings in time and effort can be realized, in which the synthesis efforts are guided by the simulation results. (northwestern.edu)
  • The cyclotides from the different subfamilies exhibited clearly different binding orientations at the micelle surface. (rcsb.org)
  • We are proud to offer our comprehensive Pharmaceutical Grade Bio Charged Activated Charcoal Formula, using our NANO bio-technology delivery system known as Micelle. (organically-kismet.store)