Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. (1/1423)

Uncoupling protein 2 (UCP2) uncouples respiration from oxidative phosphorylation and may contribute to obesity through effects on energy metabolism. Because basal metabolic rate is decreased in obesity, UCP2 expression is predicted to be reduced. Paradoxically, hepatic expression of UCP2 mRNA is increased in genetically obese (ob/ob) mice. In situ hybridization and immunohistochemical analysis of ob/ob livers demonstrate that UCP2 mRNA and protein expression are increased in hepatocytes, which do not express UCP2 in lean mice. Mitochondria isolated from ob/ob livers exhibit an increased rate of H+ leak which partially dissipates the mitochondrial membrane potential when the rate of electron transport is suppressed. In addition, hepatic ATP stores are reduced and these livers are more vulnerable to necrosis after transient hepatic ischemia. Hence, hepatocytes adapt to obesity by up-regulating UCP2. However, because this decreases the efficiency of energy trapping, the cells become vulnerable to ATP depletion when energy needs increase acutely.  (+info)

Metabolic regulation, activity state, and intracellular binding of glucokinase in insulin-secreting cells. (2/1423)

Regulation of glucose-induced insulin secretion is crucially dependent on glucokinase function in pancreatic beta-cells. Glucokinase mRNA expression was metabolically regulated allowing continuous translation into enzyme protein. Glucokinase enzyme activity in the beta-cell was exclusively regulated by glucose. Using a selective permeabilization technique, different intracellular activity states of the glucokinase enzyme in bioengineered glucokinase-overexpressing RINm5F tissue culture cells were observed. These results could be confirmed in analogous experiments with dispersed islet cells. A diffusible glucokinase fraction with high enzyme activity could be distinguished from an intracellularly bound fraction with low activity. Glucose induced a significant long-term increase of the active glucokinase fraction. This effect was accomplished through the release of glucokinase enzyme protein from an intracellular binding site of protein character. The inhibitory function of this protein factor was abolished through proteolytic digestion or heat inactivation. Northern blot analyses revealed that this binding protein was not identical to the well-known liver glucokinase regulatory protein. This hitherto unknown new protein factor may have the function of a glucokinase regulatory protein in the pancreatic beta-cell, which may regulate glucokinase enzyme activity in a glucose-dependent manner.  (+info)

Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. (3/1423)

A pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) was cloned using a subtractive cDNA expression cloning procedure from mouse insulinoma tissue. Two alternatively spliced variants that differed by the presence or absence of a 118-bp exon (exon IV) were detected in normal balb/c mice, diabetic ob/ob mice, and insulinoma tissue. The longer, 1901-bp full-length cDNA encoded a 355-amino acid protein (molecular weight 40,684) structurally related (50% overall identity) to the liver glucose-6-phosphatase and exhibited similar predicted transmembrane topology, conservation of catalytically important residues, and the presence of an endoplasmic reticulum retention signal. The shorter transcript encoded two possible open reading frames (ORFs), neither of which possessed His174, a residue thought to be the phosphoryl acceptor (Pan CJ, Lei KJ, Annabi B, Hemrika W, Chou JY: Transmembrane topology of glucose-6-phosphatase. J Biol Chem 273:6144-6148, 1998). Northern blot and reverse transcription-polymerase chain reaction analysis showed that the mRNA was highly expressed in pancreatic islets and expressed more in beta-cell lines than in an alpha-cell line. It was notably absent in tissues and cell lines of non-islet neuroendocrine origin, and no other major tissue source of the mRNA was found. During development, it was expressed in parallel with insulin mRNA. The mRNA was efficiently translated and glycosylated in an in vitro translation/membrane translocation system and readily transcribed into COS 1, HIT, and CHO cells using cytomegalovirus or Rous sarcoma virus promoters. Whereas the liver glucose-6-phosphatase showed activity in these transfection systems, the IGRP failed to show glucose phosphotransferase or phosphatase activity with p-nitrophenol phosphate, inorganic pyrophosphate, or a range of sugar phosphates hydrolyzed by the liver enzyme. While the metabolic function of the enzyme is not resolved, its remarkable tissue-specific expression warrants further investigation, as does its transcriptional regulation in conditions where glucose responsiveness of the pancreatic islet is altered.  (+info)

Resistance to hepatic action of vasopressin in genetically obese (ob/ob) mice. (4/1423)

1. Fatty acid synthesis, measured in the perfused liver of genetically obese (ob/ob) mice with 3H2O or [14C]actate, did not show the inhibition by [8-arginine]vasopressin (antidiuretic hormone) that is observed in livers from normal mice. 2. Hepatic glycogen breakdown in obese mice was stimuulated by vasopressin, but not as extensively as in lean mice. 3. If obese mice received a restricted amount of food, then fatty acid synthesis still did not respond to vasopressin, but glycogen breakdown was fully stimulated. 4. Cholesterol synthesis was not inhibited by vasopressin in livers from obese mice. 5. Vasopressin inhibited fatty acid synthesis in intact lean mice, but not in obese animals. 6. These results suggest that genetic obesity could be due to an inborn error within the mechanisms (other than adenylate cyclase) which mediate responses to extracellular effectors.  (+info)

Induction of uncoupling protein-2 (UCP2) gene expression on the differentiation of rat preadipocytes to adipocytes in primary culture. (5/1423)

We have examined uncoupling protein-2 (UCP2) gene expression in the adipose tissue of obese and normal rats and mice, and also in differentiated rat adipocytes in primary culture. Expression of the UCP2 gene was examined in rat and mouse adipose tissues using both RT-PCR and Northern blotting. Although the RT-PCR was not quantitative, the band corresponding to the UCP2 mRNA was stronger in white adipose tissue than in brown fat, regardless of the body weight of the rats. In agreement with the RT-PCR data, there was a higher level of UCP2 mRNA in the white adipocytes than in brown adipocytes, the level being greater in obese mice. Fibroblastic preadipocytes were obtained from the inguinal fat pad of suckling rats. Lipid droplets developed inside the cells upon differentiation and adipsin and UCP2 mRNAs were detected by Northern blotting. Both mRNAs were evident in the adipocytes at 4, 6, and 10 d after the induction of differentiation. There was no indication that the expression of UCP2 was markedly affected by the addition of leptin, dexamethasone or isoprenaline.  (+info)

The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6J ob/ob). (6/1423)

Some individuals of the mixed group of "lean" littermates (+/ob and +/+) of (C57BL/6J ob/ob) often suggest phenotypic characteristics of ob/ob animals. Therefore, it was of interest to determine whether expression of the ob gene had physiological significance in +/ob animals. Body weight (BW), fasting blood glucose (FBG), and body core temperature (Tr) were monitored between 62 and 364 days of age in +/+ and +/ob mice. Among females but not males, +/ob mice were heavier (P = 0.003) and FBG levels were greater (P = 0.04) than in +/+ animals. Comparison of Tr indicated differences suggesting falling Tr in +/ob but rising Tr in +/+ mice with age in males but not females. Multivariate analysis of variance yielded genotype effects for both males (P = 0.002) and females (P = 0.02). BW, FBG, and Tr alone were sufficient at the 75% level for genotypic characterization and separation of +/? animals as +/ob or +/+; clearly, expression of the ob gene in heterozygotes of the +/ob animal may make the mixed +/? group inappropriate as lean controls.  (+info)

Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. (7/1423)

Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.  (+info)

Rodent mutant models of obesity and their correlations to human obesity. (8/1423)

Obesity is a heath problem affecting a significant fraction of adult Americans and is on the rise globally. It is of importance to find treatments that achieve medically significant weight loss and successful long-term maintenance of a desired weight. Recent transgenic mouse studies and genetic characterization of spontaneous rodent obesity mutants, together with gene linkage analysis in humans, have led to an increased understanding of the physiologic and molecular mechanisms underlying obesity. However, much remains to be studied in this complex field of research. In this review, we discuss the physiology and genetics underlying obesity and how studies in rodents and humans are converging, producing a greater understanding of the mechanisms underlying this health problem.  (+info)

Non-obese Diabetic mice, i.e., NOD mice, may be a more appropriate model of the human disease. These mice are genetically ... Ffar2 gene knockout mice developed more severe disease than control mice; 4) two studies found that normal mice but not Ffar2 ... Ffar2 gene knockout mice (i.e., mice that have had their Ffar2 genes removed or inactivated) have decreased pancreatic beta ... Studies have reported that compared to control mice, germ-free mice (which lack SCFAs in their gastrointestinal tracts) have ...
Non-obese diabetic (NOD) mice, which develop diabetes mellitus type 1. Murphy Roths large (MRL) mice, with unusual regenerative ... The laboratory mouse genome has been sequenced and many mouse genes have human homologues. Lab mice sold at pet stores for ... "Researchers add mice to list of creatures that sing in the presence of mates"-Study of male mouse "song" with mouse song ... the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). Mice have been used in ...
The obese mouse lost only fat. The lean mouse lost muscle mass and fat. Harris concluded that leptin levels are increased in ... After injecting leptin into each pair's obese mouse, she found that leptin circulated between the conjoined animals, but the ... The two mice were conjoined in the experiment, and demyelination was induced via injection into the older mice. The experiment ... Enhanced immunity from the younger mouse also promoted the general health of the older mouse in each pair. The results of this ...
The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. Non-obese diabetic (NOD) mice exhibit a susceptibility ... Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. Diabetes develops in ... "Non-Obese Diabetic (NOD) Mouse BAC Library". National Institute of Allergy and Infectious Diseases. Retrieved 2006-05-15. ... Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980). "Breeding of a non-obese, diabetic strain of mice ...
As shown with mice, obese mice are prone to liver cancer, likely due to two factors. Obese mice have increased pro-inflammatory ... Obese mice also have higher levels of deoxycholic acid, a product of bile acid alteration by certain gut microbes, and these ...
as autoimmune non-obese-type diabetes mice. Lack of functional T and B cells that is derived from a mutation of protein kinase ... Cancer Infectious Diseases Regenerative Medicine Hematology Humanized mouse Nude mouse SCID mouse M. Ito and, et al. (2002). " ... such as nude mouse and NOD/scid mouse. Thus, the mouse can be the best model as a highly efficient recipient of human cells to ... The NOG mouse was generated in CIEA in 2000 by back-cross mating of C57BL/6J-IL-2Rγnull mouse that was originally developed by ...
Minimum: A mouse and Chlorophylle's best friend. He is smaller and more obese than Chlorophylle. Due to his stupidity and more ... Fictional mice and rats, Dormice, Anthropomorphic mice and rats, Belgian comics characters, Lombard Editions titles). ... Mitron XIII: A mouse who is the king of Coquefredouille. Anthracite: A huge black rat who is Chlorophylle's arch nemesis. He is ... Comics about mice and rats, Comics set in forests, Comics adapted into animated series, Comics adapted into television series, ...
In mice rendered obese and diabetic by feeding a high-fat, high-sugar diet, a study performed at the National Institute of ... In a later study, SRT1720 increased mean lifespan of obese, diabetic mice by 21.7%, similar to the earlier study, but there was ... Aug 2011). "SRT1720 improves survival and healthspan of obese mice". Scientific Reports. 1 (70): 70. Bibcode:2011NatSR...1E.. ... as compared to other short-lived obese, diabetic mice; however, treated animals still lived substantially shorter lives than ...
"Appetite-suppressing molecule helps obese mice lose weight". New Scientist. Retrieved 18 July 2022. Li VL, He Y, Contrepois K, ... with improved cognitive function in aged mice and that increasing the amount of GPLD1 produced by the mouse liver in old mice ... Evidence in transgenic mouse models of AD, in which the mice have an artificially elevated amyloid load, suggests that exercise ... Mice that had access to running wheels and other such exercise equipment had better neuronal growth in the neural systems ...
Wong C (15 June 2022). "Appetite-suppressing molecule helps obese mice lose weight". New Scientist. Retrieved 18 June 2022. ... In mice, high levels of Lac-Phe in the blood cause a decrease of food intake. In mammals it is created from (S)-lactate and L- ... Oral intake of Lac-Phe does not have anti-obesity effects in mice. Acyl group Lactoyl, the acyl group derived from lactic acid ...
"Hunger Suppressor Slimmed Lab Mice, But Not Humans. Obese Mice Have A Shortage Of The Hormone Leptin. Heavy People Have A ... "Doubt Is Cast On Role of Faulty Obese Gene. The Cause Of Obesity In Mice Does Not Apply To Humans, Researchers Said. If Only It ... "Positional cloning of the mouse obese gene and its humanhomologue". Nature. 372 (6505): 425-432. Bibcode:1994Natur.372..425Z. ... of obese people with diabetes. Moreover, in people with pre-diabetes the gastric bypass surgery prevents the development of ...
... a non-obese mouse colony being studied at the Jackson Laboratory produced a strain of obese offspring, suggesting that a ... and obese individuals have higher leptin levels in their blood circulation, compared with non-obese individuals. In obese ... Mice homozygous for the so-called ob mutation (ob/ob) ate voraciously and were massively obese. In the 1960s, a second mutation ... Mice with a mutation in the leptin receptor gene that prevents the activation of STAT3 are obese and exhibit hyperphagia. The ...
The reward value of sucrose in leptin-deficient obese mice. Mol Metab. 2013 Dec 5;3(1):73-80. doi: 10.1016/j.molmet.2013.10.007 ... The reward value of sucrose in leptin-deficient obese mice. Molecular metabolism 3 (1), 73-80 279 AI Domingos. Leptin: a ... "Mouse brains eavesdrop on their fat" by Alejandra Manjarrez, The New Scientist ft. Ana Domingos "Food for Thought" Ana Domingos ...
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M. (1994). Positional cloning of the mouse obese gene ... Binge eating disorder (BED) Obese individuals with binge eating disorder have been compared with obese controls to see if there ... Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269,540-543. Elmquist, J.K., Elias, C.F., ... It has also been found that children, particularly obese children, were faster at pushing a positive key than a negative key ...
... /MC4 double knockout transgenic mice were found morbidly obese. Also, the treatment of MC4/MRAP2 transfected cells with ... MRAP2 knockout mice models revealed the obesity phenotype of those models to be different from the phenotype caused by MC4 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "MRAP2 melanocortin ... Most of the identified mutations were detected in obese individuals with no obesity-related symptoms and those mutations. ...
Prior to entering human clinical trials, Faustman's approach was tested in non-obese diabetic mice (NOD mice), a strain of mice ... Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH (2006). "Reversal of diabetes in non-obese diabetic mice ... "Reversal of Sjogren's-like syndrome in non-obese diabetic mice". Ann Rheum Dis. 66 (6): 812-4. doi:10.1136/ard.2006.064030. PMC ... Injecting the mice with a common inflammatory agent that increases the production of TNF-α, called complete Freund's adjuvant ( ...
September 2009). "The protein kinase IKKepsilon regulates energy balance in obese mice". Cell. 138 (5): 961-975. doi:10.1016/j. ... reduced inflammation and attenuated hepatic steatosis without affecting food intake in obese mice. It produced a statistically ... March 2013). "An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice". ... significant reduction in glycated hemoglobin and fructosamine in obese patients with type 2 diabetes and nonalcoholic fatty ...
Furthermore, this effect was exaggerated when the mice became obese from a high fat diet. Diagrammatic sectional view of the ... discovered the protein leptin that the genetically obese mouse lacked. Leptin is produced in the white adipose tissue and ... August 2017). "Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice". Journal of Bone and Mineral ... "Effects of the obese gene product on body weight regulation in ob/ob mice". Science. 269 (5223): 540-543. Bibcode:1995Sci...269 ...
"Apelin stimulates glucose utilization in normal and obese insulin-resistant mice". Cell Metab. 8 (5): 437-45. doi:10.1016/j. ... Most obese people have elevated levels of insulin, which may therefore be the reason why obese people have been reported to ... Studies performed on mice knocked out for the apelin receptor gene have suggested the existence of a balance between ... Aged apelin knockout mice develop progressive impairment of cardiac contractility. Apelin acts as a mediator of the ...
These mice have very low levels of estrogen and are obese. Obesity was also observed in estrogen deficient female mice lacking ... Female mice that were given a calorically restricted diet during the majority of their lives maintained higher levels of ERα in ... Hewitt KN, Boon WC, Murata Y, Jones ME, Simpson ER (Sep 2003). "The aromatase knockout mouse presents with a sexually dimorphic ... A dramatic demonstration of the importance of estrogens in the regulation of fat deposition comes from transgenic mice that ...
It has been shown to promote insulin resistance in obese mice. Leukotriene B4 (LTB4) is a leukotriene involved in inflammation ... San Diego School of Medicine has shown that leukotriene B4 promotes insulin resistance in obese mice. Obesity is the major ... "LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes". Nature Medicine. 21 (3): ...
Anti-hyperglycaemic effects were studied in diabetic and severely obese mice. Gingerol compounds increased glucose uptake in ... "Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice". Cytotechnology. 67 (4): 641-52 ... Most research on [6]-Gingerol has been on either mouse subjects (in-vivo) or on cultured human tissue (in-vitro) and may be ... In a meta analysis looking at many different phytochemical effects on prostate cancer, two specific studies using mice observed ...
In the ob/ob mouse, mutations in the leptin gene resulted in the obese phenotype opening the possibility of leptin therapy for ... Zhang, Y; Proenca, R; Maffei, M; Barone, M; Leopold, L; Friedman, JM (Dec 1, 1994). "Positional cloning of the mouse obese gene ... "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity". The Journal of Clinical ...
This dip in leptin levels instructs the body to search for food.[citation needed] In studies of obese mice, Friedman has found ... Zhang, Y; Proenca, R; Maffei, M; Barone, M; Leopold, L; Friedman, JM (December 1994). "Positional cloning of the mouse obese ... "Obese Locus in WNIN/Obese Rat Maps on Chromosome 5 Upstream of Leptin Receptor". PLOS ONE. 8 (10): 10. Bibcode:2013PLoSO... ... He is also involved in the research related to the 1st inbred rat model of obesity and aging, also known as WNIN/Ob obese rats ...
In the ob/ob mouse, mutations in the leptin gene resulted in the obese phenotype opening the possibility of leptin therapy for ... Zhang, Y; Proenca, R; Maffei, M; Barone, M; Leopold, L; Friedman, JM (Dec 1, 1994). "Positional cloning of the mouse obese gene ... Although administration of leptin may be effective in a small subset of obese individuals who are leptin-deficient, most obese ... "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity". The Journal of Clinical ...
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (December 1994). "Positional cloning of the mouse obese gene and ...
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (December 1994). "Positional cloning of the mouse obese gene and ... Similarly, in mice, a postprandial increase in hepatic leptin expression has also been reported. However, in grass carp, ... May 1997). "Crystal structure of the obese protein leptin-E100". Nature. 387 (6629): 206-209. Bibcode:1997Natur.387..206Z. doi: ... "Transient increase in obese gene expression after food intake or insulin administration". Nature. 377 (6549): 527-529. Bibcode: ...
Edwardson JA, Hough CA (April 1975). "The pituitary-adrenal system of the genetically obese (ob/ob) mouse". The Journal of ... Studies of mice and monkeys show that repeated stress-and a high-fat, high-sugar diet-stimulate the release of neuropeptide Y, ... Two results suggest that NPY might protect against alcoholism: knock-out mice in which a type of NPY receptor has been removed ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Heilig M, Widerlöv ...
... clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock ... In mice, the disruption to the essential clock genes, Period genes (Per2, Per1) caused by circadian misalignment was found to ... Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM (May 2006). "A clock shock: mouse CLOCK is not required for ... Mutations or deletions of clock genes in mice have demonstrated the importance of body clocks to ensure the proper timing of ...
"Exercise Decreases Marrow Adipose Tissue through β-Oxidation in Obese Running Mice". Journal of Bone and Mineral Research. 32 ( ...
A study conducted in 2013 found that, while INSIG1 and SREBF1 mRNA expression was decreased in the adipose tissue of obese mice ... August 2017). "Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice". Journal of Bone and Mineral ... the amount of active SREBF1 was increased in comparison with normal mice and non-obese patients. This downregulation of INSIG1 ... Individuals who become obese as adults, rather than as adolescents, have no more adipocytes than they had before. People who ...
Johnson PR, Hirsch J (January 1972). "Cellularity of adipose depots in six strains of genetically obese mice" (PDF). Journal of ... Mice with wildtype agouti will be grey, with each hair being partly yellow and partly black. Loss of function mutations in mice ... Two genetically identical mice could look very different phenotypically due to the mothers' diets while the mice were in utero ... In mice, the yellow coat color is also associated with health problems in mice including obesity and diabetes. Agouti signaling ...
The images and graph demonstrate that BMAT is higher in obese compared with lean mice. B6 mice were fed HFD from age 4 wk until ... August 2017). "Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice". Journal of Bone and Mineral ... November 2004). "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered ... August 2015). "Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice". ...
We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their ... These data sets offer the currently most comprehensive public record of the β-cell mass distribution in the mouse. As such, ... Lindstrom, P. The physiology of obese-hyperglycemic mice [ob/ob mice]. Scientific World Journal 7, 666-685 (2007). ... We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their ...
... the drug consistently normalized body weight and reversed metabolic damage in obese middle-aged mice. ... Repurposed drug helps obese mice lose weight, improve metabolic function Share: Print page Facebook share Linkedin share ... effectively normalizing their weight to that of obese mice who were switched back to standard diet. Mice in either disulfiram ... Both groups of obese mice (control and disulfiram) were not subjected to any form of exercise, nor did they demonstrate ...
Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had ... Tandem mass spectrometry analysis of plasma from obese mice under CR showed no difference in Cur metabolite levels between ... 47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to induce obesity. Then, mice were divided ... It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD ...
Altogether, these data strongly suggest that the modulation of the gut microbiota using prebiotics in obese mice, could act ... Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut ... Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut ... The mice were fed the same control diet as described in experiment 1. The mice were separated into two groups and injected ...
Altogether, these data strongly suggest that the modulation of the gut microbiota using prebiotics in obese mice, could act ... Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut ... Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut ... The mice were fed the same control diet as described in experiment 1. The mice were separated into two groups and injected ...
1146-P: The Effects of the SGLT2 Inhibitor Empagliflozin on Fatty Liver in Diet-Induced Obese Mice WEI WANG; WEI WANG ... The Effects of the SGLT2 Inhibitor Empagliflozin on Fatty Liver in Diet-Induced Obese Mice. Diabetes 1 June 2020; 69 ( ... In our study, 8-week-old C57BL/6 mice were fed on a normal diet or a high-fat diet for 16 weeks. After the diet induction, they ...
Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways ... and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). Chemerin decreased insulin-induced ... Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. ... CCX832 also partially restored vascular insulin responses in db/db and high-fat diet-fed mice. Our novel in vivo findings ...
... he was struck by similarities in behavior between obese mice and Parkinsonian mice. Based on that observation, he hypothesized ... Inactivity in obese mice linked to altered dopamine receptors and a decreased motivation to move. by Cell Press ... In the study, mice were fed either a standard or a high-fat diet for 18 weeks. Beginning in the second week, the mice on the ... By studying lean mice that were engineered to have the same defect in the D2 receptor, they found that those mice did not gain ...
Mealworm protein didnt cause obese mice to lose weight, but their rate of weight gain slowed relative to mice consuming high- ... Study: Insect protein slows weight gain, boosts health status in obese mice. July 26, 2023 ... but most have used genetically altered mice designed to stay obese no matter what. Swansons team intentionally used "wild type ... A new study in mice from the University of Illinois Urbana-Champaign suggests replacing traditional protein sources with ...
Decrease of microglia and fatty liver in obese mice by germinated Sang-Yod rice Nuntika Wangpradit, Supattra Prom-in, Jaya ... Our previous study indicated that learning and cognition of obese mice were enhanced by germinated Sang-Yod rice intervention. ... In contrast, microglia is simply observed in this brain area of mice in HFD group. Limitation of high fat in foods should be ... Thirty-two male C57BL/6J mice are divided into 4 groups (n = 8), and distinctly assigned to receive a different diet for 12 ...
... Details Written by Chip Rose Chip Rose Category: ... effectively normalizing their weight to that of obese mice who were switched back to standard diet. Mice in either disulfiram ... Both groups of obese mice (control and disulfiram) were not subjected to any form of exercise, nor did they demonstrate ... As expected, the mice who stayed on the high-fat diet alone continued to gain weight and show metabolic problems. Mice who ...
Scientists have discovered a new type of brain cell that increases appetite in mice even when their bodies are satiated, ... Previous studies on mice have shown that restricting AgRP-positive NPY neurons in the brain can significantly reduce food ... Scientists have discovered a new type of brain cell that increases appetite in mice even when their bodies are satiated, ... Although these mechanisms have only been observed in mice, they may provide useful insights into the neurological factors that ...
... in mice. The treatment with infliximab improved markers of liver damage in mice with pre-existing early MASH. In TNFα-/- mice, ... TNFα is a key trigger of inflammation in diet-induced non-obese MASLD in mice. ... TNFα is a key trigger of inflammation in diet-induced non-obese MASLD in mice. ... mice compared to wild-type mice with early MASH, markers of intestinal barrier function were similarly impaired in both MASH- ...
Mealworm protein didnt cause obese mice to lose weight, but their rate of weight gain slowed relative to mice consuming high- ... Study: Insect protein slows weight gain, boosts health status in obese mice University of Illinois 30 Lug 2023 Scienceonline ... but most have used genetically altered mice designed to stay obese no matter what. Swansons team intentionally used "wild type ... Swansons team fed mice a high-fat diet (46% calories from fat) with casein, a protein from dairy, for 12 weeks before ...
We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice. The mice were divided ... The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also ... The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious ... HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice. Access & ...
Mealworm protein didnt cause obese mice to lose weight, but their rate of weight gain slowed relative to mice consuming high- ... but most have used genetically altered mice designed to stay obese no matter what. Swansons team intentionally used wild type ... The mice then started eating two types of mealworms in a dried, powdered form similar to flour, substituting either 50% or 100 ... By the time mealworms were introduced, the high-fat diet group was obese and experiencing metabolic syndrome, a cluster of ...
Abnormal trigeminal sensory processing in obese mice. Rossi, Heather L.; Broadhurst, Kimberly A.; Luu, Anthony S.K.; More ... Obese mice display photophobic behavior after stimulation of the trigeminal nerve (V2) with capsaicin. Cultured trigeminal ... physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice ...
Drug from David Sinclairs Sirtris Start-Up Lengthens Life of Obese Mice. "An obese mouse given the drug SRT-1720, center, and ... These and other positive health effects enable the obese mice to live 44 percent longer, on average, than obese mice that did ... "Longer Lives for Obese Mice, With Hope for Humans of All Sizes." The New York Times (Fri., August 19, 2011): A1 & A3.. (Note: ... researchers have found they can substantially extend the average life span of obese mice with a specially designed drug. ...
Williamson L, Ayalon I, Shen H, Kaplan J. Hepatic STAT3 inhibition amplifies the inflammatory response in obese mice during ... Williamson, L, Ayalon, I, Shen, H & Kaplan, J 2019, Hepatic STAT3 inhibition amplifies the inflammatory response in obese mice ... Hepatic STAT3 inhibition amplifies the inflammatory response in obese mice during sepsis. / Williamson, Lauren; Ayalon, Itay; ... High-fat-fed mice with hepatic STAT3 inhibition gained more weight and had more fat than control mice on the same diet, and ...
The researchers also used in-vitro fertilization to implant fertilized eggs from obese mice into normal-weight mice to carry ... Obese mouse mothers trigger heart problems in offspring. Washington University School of Medicine • March 22, 2019. ... Notably, the researchers found multigenerational heart problems, even when the mouse offspring were not obese and ate a normal ... in the offspring of obese mouse mothers and in two subsequent generations. ...
A new study reports that inhibiting a liver enzyme in obese mice decreases their appetite, increases expenditure of fat, and ... A new study reports that inhibiting a liver enzyme in obese mice decreases their appetite, increases expenditure of fat, and ... The CNOT6L inhibitor, labeled iD1, stabilized GDF15 and FGF21 mRNAs in obese mice, increasing blood levels of the two proteins ... Liver enzyme discovery decreases appetite in obese mice, leads to weight loss. May 10, 2022 ...
Study finds additive and interactive synbiotic effects in obese mice 07-Aug-2023. By Asia Sherman ...
Study: Açai powder improves cognition and insulin sensitivity in obese mice 19-Jan-2023. By Asia Sherman ... 5 Study suggests astaxanthin and CrossFit improves metabolic health in obese participants ...
... in the non-obese diabetic (NOD) mouse. Prior to the CY challenge (350 mgkg body weight), female euglycemic NOD mice were ... in the non-obese diabetic (NOD) mouse. Prior to the CY challenge (350 mgkg body weight), female euglycemic NOD mice were ... Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor. NICOLETTI ... of the control mice (group A). In contrast, repeated injections with sIL-1R protected NOD mice from insulin-dependent diabetes ...
... Sci Rep. 2017 Mar 10:7 ... Treatment of BTBR ob/ob mice with 4 mM carnosine for 18 weeks reduced plasma glucose and HbA1c, concomitant with elevated ... Also, albuminuria and kidney weights were reduced in carnosine-treated mice, which showed less glomerular hypertrophy due to a ... ob/ob mice, a type 2 diabetes model which develops a phenotype that closely resembles advanced human DN. ...
Bimagrumab co-administration with incretins drives additive fat loss while preserving muscle mass in obese mice. ...
In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total ... In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total ... In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total ... In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total ...
OX-A-induced enhancement of 2-AG levels in different brain areas of obese ob/ob mice. ...
Non-obese Diabetic mice, i.e., NOD mice, may be a more appropriate model of the human disease. These mice are genetically ... Ffar2 gene knockout mice developed more severe disease than control mice; 4) two studies found that normal mice but not Ffar2 ... Ffar2 gene knockout mice (i.e., mice that have had their Ffar2 genes removed or inactivated) have decreased pancreatic beta ... Studies have reported that compared to control mice, germ-free mice (which lack SCFAs in their gastrointestinal tracts) have ...
  • 47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to induce obesity. (springer.com)
  • In our study, 8-week-old C57BL/6 mice were fed on a normal diet or a high-fat diet for 16 weeks. (diabetesjournals.org)
  • Molecular and vascular mechanisms were probed in mesenteric arteries and cultured vascular smooth muscle cells (VSMCs) from C57BL/6J, nondiabetic lean db/m, and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). (gla.ac.uk)
  • Chemerin decreased insulin-induced vasodilatation in C57BL/6J mice, an effect prevented by CCX832 (ChemR23 antagonist) treatment. (gla.ac.uk)
  • Thirty-two male C57BL/6J mice are divided into 4 groups (n = 8), and distinctly assigned to receive a different diet for 12 weeks, including normal diet (CONTROL group), high fat diet (HFD group), high fat diet plus 20 mg simvastatin/kg/day (POSITIVE group), and high fat diet plus 0.5% germinated Sang-Yod rice/kg/day (HFD-GR group). (peertechzpublications.com)
  • In pharmacological inhibition studies, male C57BL/6 mice were randomized to a high-fat (60% kcal fat) or normal (16% kcal fat) diet for 6-7 wk and pretreated with Stattic before inducing sepsis by cecal ligation and puncture. (tau.ac.il)
  • C57BL/6 mice were randomised to one of three diets - low-fat diet (LFD), HFD and HFD plus 4 % (w/w) blueberry (HFD+B) - for 8 or 12 weeks. (blueberry.org)
  • Male C57BL/6J (B6) mice were fed either a high-fat diet (HF, 45% kcal fat) or HF diet supplemented with EPA (HF-EPA, 6.75% kcal EPA) for 11 weeks. (ttu.edu)
  • Forty-eight male C57BL/6J mice were assigned to a high-fat diet (control), HFD + 400 mg GGOH/kg diet (GG), HFD + 0.5% GTP water (TP), or HFD + GGOH + GTP (GGTP) diet for 14 weeks. (syr.edu)
  • Eight weeks of feeding C57BL/6 mice with the standardized O. aristatus extract (400 mg/kg) inhibited the progression of NAFLD. (edu.sy)
  • Methods and results: C57BL/6N mice were fed with a normal diet, HFD (40% fat of total energy), and HFD-supplemented with 0.03% oleuropein for 10 wk. (elsevierpure.com)
  • Male C57BL/6 mice were fed with a normal diet (ND) or ND supplemented with HN (NDh) or HO (NDo). (frontiersin.org)
  • Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. (bvsalud.org)
  • Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single walled carbon nanotube s in C57BL/6 mice. (cdc.gov)
  • However, even in a small animal like the mouse, the predominant model system for studies of diabetes and metabolic stress, the ability to obtain a detailed spatial and quantitative view of the pancreatic β-cell mass distribution has been limited. (nature.com)
  • Within the academia and the pharmaceutical industry alike, the ob/ob mouse model is widely used for studies on initial aspects of metabolic disturbances leading to type 2 diabetes, including insulin resistance and obesity 11 . (nature.com)
  • An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. (nih.gov)
  • As expected, this diet made the mice overweight and they started to show signs of pre-diabetes-like metabolic problems, such as insulin resistance and elevated fasting blood sugar levels. (nih.gov)
  • As expected, the mice who stayed on the high-fat diet alone continued to gain weight and show metabolic problems. (nih.gov)
  • The mice in the remaining two groups, with either a low or high dose of disulfiram added to their still-fatty food, showed a dramatic decrease in their weight and related metabolic damage. (nih.gov)
  • According to study's research team, the key to the positive results seem to stem from disulfiram's anti-inflammatory properties, which helped the mice avoid imbalances in fasting glucose and protected them from the damage of fatty diet and weight gain while improving metabolic efficiency. (nih.gov)
  • CR favorably impacted metabolic profiles of obesity (i.e., lower body weight, plasma glucose and plasma insulin) in obese mice, but the addition of Cur and/or Pip into the CR diet resulted in no further measurable benefit on total body weight. (springer.com)
  • In the present study, we further investigated whether Cur and/or Pip could improve metabolic profiles in obese mice subjected to CR on a HFD. (springer.com)
  • Obese and diabetic mice display enhanced intestinal permeability and metabolic endotoxaemia that participate in the occurrence of metabolic disorders. (bmj.com)
  • 1 2 Evidence that the gut microbiota composition can be different between healthy and obese and/or type 2 diabetic patients has led to the investigation of this environmental element as a key factor in the pathophysiology of metabolic diseases. (bmj.com)
  • By the time mealworms were introduced, the high-fat diet group was obese and experiencing metabolic syndrome, a cluster of conditions increasing risk of heart attack, stroke, diabetes, and other health problems. (illinois.edu)
  • Here, we determined the effects of a treatment with the anti-TNFα antibody infliximab and a genetic deletion of TNFα, respectively, in the development of non-obese diet -induced early metabolic dysfunction-associated steatohepatitis (MASH) in mice . (bvsalud.org)
  • Indeed, past work by this group confirmed that mitochondrial problems also exist in the skeletal muscle, leading to whole-body metabolic abnormalities, such as insulin resistance, in the offspring of obese mouse mothers and in two subsequent generations. (wustl.edu)
  • This study examined the efficacy of supplemental L: -carnitine as an adjunctive diabetes therapy in mouse models of metabolic disease. (nih.gov)
  • The results showed in this study suggest that, together with cytoskeletal proteins, mitochondria and metabolic proteins are changing their post-translational status in brains of obese mice. (lu.se)
  • Specifically, proteins involved in metabolic pathways and in mitochondrial functions are mainly downregulated in mice fed with obesogenic diets compared to SD. (lu.se)
  • Prebiotic-treated mice exhibited a lower plasma lipopolysaccharide (LPS) and cytokines, and a decreased hepatic expression of inflammatory and oxidative stress markers. (bmj.com)
  • Our data suggest that TNFα is a key regulator of hepatic inflammation and insulin resistance associated with the development of early non-obese MASH. (bvsalud.org)
  • To investigate obesity in mice with hepatic-specific STAT3 inhibition, we randomized mice to a high-fat or normal diet as described above for 6 mo before induction of sepsis. (tau.ac.il)
  • High-fat-fed mice with hepatic STAT3 inhibition gained more weight and had more fat than control mice on the same diet, and obesity increased neutrophil infiltration to the liver of these mice during sepsis. (tau.ac.il)
  • In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total cholesterol, adipocyte size, crown-like structures, proinflammatory cytokine secretion (IL-6 and tumor necrosis factor α) in adipose tissue, liver injury, hepatic steatosis, and inflammation foci, while treatment with IL-10 or PSL alone did not. (elsevierpure.com)
  • Gpr120 agonist treatment of high-fat diet-fed obese mice causes improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity and decreased hepatic steatosis. (elsevierpure.com)
  • However, no studies have demonstrated the molecular effects of short-term strength training on the accumulation of hepatic fat in obese mice. (bioscientifica.com)
  • Carnitine supplementation improved insulin-stimulated glucose disposal in genetically diabetic mice and wild-type mice fed a high-fat diet, without altering body weight or food intake. (nih.gov)
  • Therefore, PBMT might ameliorate whole-body insulin resistance in diabetic mice. (google.com)
  • It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD induced inflammation. (springer.com)
  • A new study in mice from the University of Illinois Urbana-Champaign suggests replacing traditional protein sources with mealworms in high-fat diets could slow weight gain, improve immune response, reduce inflammation, enhance energy metabolism, and beneficially alter the ratio of good to bad cholesterol. (illinois.edu)
  • is a key trigger of inflammation in diet-induced non-obese MASLD in mice. (bvsalud.org)
  • Lung inflammation and cardiovascular outcomes - whole blood gene expression studies in a lipopolysaccharide (LPS) pharyngeal aspiration mouse model. (cdc.gov)
  • Yifei Kang et al, Yellow Mealworm (Tenebrio molitor) and Lesser Mealworm (Alphitobius diaperinus) Proteins Slowed Weight Gain and Improved Metabolism of Diet-Induced Obesity Mice, The Journal of Nutrition (2023). (medtelligence.net)
  • Further analysis of the mice models identified some of the genes that connect prolonged ER stress with faulty fat metabolism in the liver. (sciencedaily.com)
  • These changes suggest a reduced metabolism and a lower activity of mitochondria in obese mice. (lu.se)
  • A similar transplant of the microbiota from Malawian children with kwashiorkor with a Malawian diet, however, produces weight loss in mice, accompanied by alterations in amino acid, carbohydrate and intermediate metabolism. (medscape.com)
  • Ephedrine reduces weight of viable yellow obese mice (avy/a)." by T T. Yen, M M. Mckee et al. (jax.org)
  • Ephedrine reduces weight of viable yellow obese mice (avy/a). (jax.org)
  • For example, when pregnant mice are fed bisphenol A (BPA), a chemical present in many commonly used products , the number of offspring with the yellow obese coat color increases dramatically. (cdc.gov)
  • Oleuropein also significantly reversed the HFD-induced elevations of adipogenic related gene expression involved in WNT10b- and galanin-mediated signalings in adipose tissue of mice. (elsevierpure.com)
  • Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice. (google.com)
  • The treatment with infliximab improved markers of liver damage in mice with pre-existing early MASH. (bvsalud.org)
  • The drug, SRT-1720, protects the mice from the usual diseases of obesity by reducing the amount of fat in the liver and increasing sensitivity to insulin. (artdiamondblog.com)
  • A new study reports that inhibiting a liver enzyme in obese mice decreases their appetite, increases expenditure of fat, and results in weight loss. (gutnews.com)
  • This study aimed to investigate the effects of short-term strength training on the mechanisms of oxidation and lipid synthesis in the liver of obese mice. (bioscientifica.com)
  • Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity. (logosbio.com)
  • Liver enzymes including alanine aminotransferase and aspartate transaminase were significantly reduced in treated mice by 74.2% _ 7.69 and 52.8% _ 7.83, respectively. (edu.sy)
  • New findings in mice suggest that merely changing meal times could have a significant effect on the levels of triglycerides in the liver. (sciencedaily.com)
  • In studying the role of circadian rhythm in the accumulation of lipids in the liver, postdoctoral fellow Yaarit Adamovich and the team in the lab of Dr. Gad Asher of the Weizmann Institute's Biological Chemistry Department, together with scientists from Dr. Xianlin Han's lab in the Sanford-Burnham Medical Research Institute, Orlando, US, quantified hundreds of different lipids present in the mouse liver. (sciencedaily.com)
  • When the scientists proceeded to check the effect of an imposed feeding regimen upon wild type mice, however, they were in for another surprise: After they provided the same amount of food -- but restricted 100% of the feeding to nighttime hours -- the team observed a dramatic 50% decrease in overall liver TAG levels. (sciencedaily.com)
  • Asher: "The striking outcome of restricted nighttime feeding -- lowering liver TAG levels in the very short time period of 10 days in the mice -- is of clinical importance. (sciencedaily.com)
  • The study, led by Tom Rutkowski, Ph.D., assistant professor of anatomy and cell biology at the UI Roy J. and Lucille A. Carver College of Medicine, and Randal Kaufman, Ph.D., professor of biological chemistry and internal medicine at the University of Michigan Medical School, shows that disrupted protein folding causes fatty liver in mice. (sciencedaily.com)
  • In addition, the team found that protein misfolding caused fatty liver in mice with the mutation. (sciencedaily.com)
  • The researchers followed up on the result and found that mice also developed fatty liver if their ability to fold proteins in the ER was genetically impaired, even when the UPR was functionally intact. (sciencedaily.com)
  • Mice with no CHOP were partially protected from fatty liver. (sciencedaily.com)
  • Here we report that a selective high-affinity, orally available, small-molecule Gpr120 agonist (cpdA) exerts potent anti-inflammatory effects on macrophages in vitro and in obese mice in vivo. (elsevierpure.com)
  • The islets contain five hormone-producing cell-types of which the insulin producing β-cells is the most prominent type (~80% in humans and mice). (nature.com)
  • Swanson's team intentionally used "wild type" mice so they would gain weight the same way many humans do: through diet. (illinois.edu)
  • Although these mechanisms have only been observed in mice, they may provide useful insights into the neurological factors that contribute to appetite and obesity in humans. (scienceinformed.com)
  • Longer Lives for Obese Mice, With Hope for Humans of All Sizes. (artdiamondblog.com)
  • Of course, mice are nocturnal animals, so in order to construe these results for humans, the timetable would need to be reversed. (sciencedaily.com)
  • Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)
  • We have evaluated the effects of a treatment with soluble interleukin-1 receptor (sIL-1R) in the accelerated model of autoimmune diabetes induced by cyclophosphamide (CY) in the non-obese diabetic (NOD) mouse. (unimol.it)
  • Thus, BPA exposure is associated with a higher number of yellow mice predisposed to obesity and diabetes. (cdc.gov)
  • In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagon-like peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
  • In obese patients with type 2 diabetes mellitus who require insulin therapy, at least one of the following is suggested: metformin, pramlintide, or GLP-1 agonists to mitigate associated weight gain due to insulin. (medscape.com)
  • Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes mellitus who are obese. (medscape.com)
  • The sirtuins help bring about the 30 percent extension of life span enjoyed by mice and rats that are kept on very low-calorie diets. (artdiamondblog.com)
  • Effects of concentrated ambient ultrafine /fine particles in insulin-resistant, obese rats. (cdc.gov)
  • For example, obesity can be transferred to germ-free mice with fecal microbiota from obese subjects, but not from lean twins. (medscape.com)
  • Increases of low-density lipoprotein and total cholesterol concentrations and the albumin/globulin ratio are found for mice fed with high fat diet. (peertechzpublications.com)
  • Scientists have discovered a new type of brain cell that increases appetite in mice even when their bodies are satiated, according to a recent study. (scienceinformed.com)
  • In genetic inhibition studies, mice were randomized by genotype before induction of sepsis. (tau.ac.il)
  • Obese mice with genetic or diet-induced forms of insulin resistance were fed rodent chow +/- 0.5% L: -carnitine for a period of 1-8 weeks. (nih.gov)
  • Under normal conditions, mice with the genetic mutation looked and behaved normally. (sciencedaily.com)
  • Figure 2 shows two mice with identical genetic codes (as with identical twins). (cdc.gov)
  • Swanson's team fed mice a high-fat diet (46% calories from fat) with casein, a protein from dairy, for 12 weeks before switching to the alternative proteins. (illinois.edu)
  • Mealworm protein didn't cause obese mice to lose weight, but their rate of weight gain slowed relative to mice consuming high-fat diets with casein. (illinois.edu)
  • However, the mutated mice were much less able to cope with cellular stress caused by disrupted protein folding than wild-type mice. (sciencedaily.com)
  • Results demonstrated that GTP supplementation improved glucose tolerance in obese mice. (syr.edu)
  • Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
  • The current results indicated that PBMT inhibited FFA generation and release in insulin-resistant adipocytes and reduced plasma FFA levels in diabetic db/db mice and HFD-fed mice. (google.com)
  • Other studies have evaluated alternative proteins for obesity weight management in mice, but most have used genetically altered mice designed to stay obese no matter what. (illinois.edu)
  • The CNOT6L inhibitor, labeled iD1, stabilized GDF15 and FGF21 mRNAs in obese mice, increasing blood levels of the two proteins. (gutnews.com)
  • The aim of the study was to identify proteins present in the brain that are changing their expression based on the diet given to the mice. (lu.se)
  • Mice treated with iD1 also showed improved insulin sensitivity and decreased blood glucose levels. (gutnews.com)
  • When scientists suppressed these neurons in mouse brains, food intake and post-meal weight gain were significantly reduced. (scienceinformed.com)
  • Given these lines of evidence, in the present study we investigated brains of mice treated with 2 obesogenic diets, high-fat diet (HFD) and high-glycaemic diet (HGD), compared to mice fed with a standard diet (SD) employing a quantitative mass spectrometry-based approach. (lu.se)
  • These findings suggest that carnitine supplementation relieves lipid overload and glucose intolerance in obese rodents by enhancing mitochondrial efflux of excess acyl groups from insulin-responsive tissues. (nih.gov)
  • Our previous study sought to evaluate whether Cur and/or Pip could potentiate CR's effect on body weight reduction in mice made obese by feeding a high-fat diet (HFD) [ 10 ]. (springer.com)
  • Study 2: Ob-CT and Ob-Pre mice were treated with GLP-2 antagonist or saline. (bmj.com)
  • Now a study done in mice is providing clues about one of the reasons why it may be hard for so many people to stick with an exercise program. (psypost.org)
  • In the study, mice were fed either a standard or a high-fat diet for 18 weeks. (psypost.org)
  • Our previous study indicated that learning and cognition of obese mice were enhanced by germinated Sang-Yod rice intervention. (peertechzpublications.com)
  • In many ways, this study presents more questions than it answers, and we plan to continue studying these mice to help answer them. (wustl.edu)
  • This study examined the combined effects of GGOH and GTP on glucose homeostasis in addition to bone remodeling in obese mice. (syr.edu)
  • Scope: The aim of the present study was to investigate the antiobesity effect of oleuropein on high-fat diet (HFD) induced body weight gain and visceral adiposity in mice, and to explore the underlying mechanisms involved. (elsevierpure.com)
  • Conclusion: This study demonstrated the oleuropein-reduced body weight gain and visceral adiposity in HFD-fed mice. (elsevierpure.com)
  • A new study finds vitamin D may be protective among asthmatic obese children living in urban environments with high indoor air pollution. (fabresearch.org)
  • Another study showed that feeding mice macadamia nut oil as a supplement reduced the size of their fat cells after 12 weeks. (medicalnewstoday.com)
  • In an obese male mouse model, individual GGOH and GTP supplementation improved glucose homeostasis, serum CTX, and trabecular microstructure of LV-4. (syr.edu)
  • However, the combined GGOH and GTP supplementation compromises such osteoprotective effects on serum CTX and trabecular bone of obese mice. (syr.edu)
  • Furthermore, the treated mice showed a reduction in serum levels of glucose (50% _ 5.71), insulin (70.2% _ 12.09), total cholesterol (27.5% _ 15.93), triglycerides (63.2% _ 16.5), low-density lipoprotein (62.5% _ 4.93) and atherogenic risk index relative to the negative control. (edu.sy)
  • Serum oxLDL levels are decreased in both lean and obese diabetic animals treated with TZDs. (jci.org)
  • CCX832 also partially restored vascular insulin responses in db/db and high-fat diet-fed mice. (gla.ac.uk)
  • Next, the scientists divided these mice into four groups to be fed four different diets for an additional 12 weeks: a standard diet alone, a high-fat diet alone, a high-fat diet with a low amount of disulfiram, or a high-fat diet with a higher amount of disulfiram. (nih.gov)
  • But the rationale behind the research is somewhat different: the researchers are trying to capture the benefits that allow mice on very low-calorie diets to live longer. (artdiamondblog.com)
  • Though perhaps revealing some effects of a healthy diet, the severity of the heart problems diminished slightly over the generations of mice that ate standard chow diets, the researchers noted. (wustl.edu)
  • Mice who switched to standard diet alone gradually saw their body weight, fat composition and blood sugar levels return to normal. (nih.gov)
  • The researchers also plan to look at how quickly the mice recover to normal activity levels once they begin eating a healthy diet and losing weight. (psypost.org)
  • Lastly, cells of the prefrontal cortex of these treated mice are morphologically normal with an absence of microglia. (peertechzpublications.com)
  • It just so happens that such benefits are much easier to demonstrate in mice under physiological stress like obesity than in normal mice. (artdiamondblog.com)
  • Obese mothers' male offspring that mated with healthy females fed a normal diet also passed on the same heart problems. (wustl.edu)
  • They are passed down by both the male and female offspring of obese mothers, even when the offspring eat a normal diet. (wustl.edu)
  • Notably, the researchers found multigenerational heart problems, even when the mouse offspring were not obese and ate a normal diet throughout their lives. (wustl.edu)
  • The researchers also used in-vitro fertilization to implant fertilized eggs from obese mice into normal-weight mice to carry the pregnancies. (wustl.edu)
  • accordingly, in parallel experiments, splenic lymphoid cells from NOD mice not challenged with CY, but treated with 2 mg/kg sIL-1R for 5 consecutive days showed a normal distribution of mononuclear cell subsets and maintained their capacity to secrete interferon-gamma and IL-2 and to proliferate in response to polyclonal mitogenic stimulation with concanavalin A. (unimol.it)
  • We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their lean controls, together with information about individual islet β-cell volumes, their three-dimensional coordinates and shape throughout the volume of the pancreas between 4 and 52 weeks of age. (nature.com)
  • To address the current lack of combined topological and quantitative information of the BCV distribution in obese ( ob/ob ) mice and their healthy lean controls, we recently assessed the full BCV distribution at 4, 8, 17, 26 and 52 weeks of age by OPT imaging analyses 12 (for schematic overview of the assay design see Fig. 1 ). (nature.com)
  • Swapping dietary saturated fats for monounsaturated fats reverses nerve damage and restores nerve function in male mice, finds new preclinical research. (fabresearch.org)
  • While mRNA expression of proinflammatory cytokines like interleukin 1 ß (Il1b) and interleukin 6 ( Il6 ) were significantly lower in livers of MASH- diet -fed TNFα-/- mice compared to wild-type mice with early MASH, markers of intestinal barrier function were similarly impaired in both MASH- diet -fed groups compared to controls. (bvsalud.org)
  • Mice on the high disulfiram dose lost as much as 40% of their body weight in just four weeks, effectively normalizing their weight to that of obese mice who were switched back to standard diet. (nih.gov)
  • When we first went down this path, we did not know what to expect, but once we started to see data showing dramatic weight loss and leaner body mass in the mice, we turned to each other and couldn't quite believe our eyes," Bernier said. (nih.gov)
  • CCX832 treatment of db/db mice decreased body weight, insulin, and glucose levels as well as vascular oxidative stress. (gla.ac.uk)
  • The investigators found that in obese mice, physical inactivity results from altered dopamine receptors rather than excess body weight. (psypost.org)
  • There's a common belief that obese animals don't move as much because carrying extra body weight is physically disabling. (psypost.org)
  • Beginning in the second week, the mice on the unhealthy diet had higher body weight. (psypost.org)
  • Surprisingly, the mice on high-fat diet moved less before they gained the majority of the weight, suggesting that the excess weight alone was not responsible for the reduced movements. (psypost.org)
  • By studying lean mice that were engineered to have the same defect in the D2 receptor, they found that those mice did not gain weight more readily on a high-fat diet, despite their lack of inactivity, suggesting that weight gain was compounded once the mice start moving less. (psypost.org)
  • Prior to the CY challenge (350 mgkg body weight), female euglycemic NOD mice were randomly divided into three groups (A-C). Groups B and C were treated daily from 1 day before to 13 days after the CY challenge with sIL-1R at doses of 0.2 and 2 mg/kg body weight. (unimol.it)
  • In the yellow mouse, a region of the DNA is unmethylated which makes the nearby Agouti gene turned on all the time, while in the brown mouse, the region is methylated and the Agouti gene is turned off. (cdc.gov)
  • When pregnant mice are exposed to BPA along with a vitamin B cocktail (including B12 and folic acid) which increase methylation of the Agouti gene, the offspring are no longer predominantly yellow and obese. (cdc.gov)
  • Both groups of obese mice (control and disulfiram) were not subjected to any form of exercise, nor did they demonstrate noticeable spontaneous behavioral changes. (nih.gov)
  • Fat degeneration, cytoplasmic vacuoles, and lipid droplets in the livers of mice treated with simvastatin and germinated Sang-Yod rice are reduced. (peertechzpublications.com)
  • The protective effect of oleuropein against HFD-induced adiposity in mice appeared to be mediated through the upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades. (elsevierpure.com)
  • To investigate how cells adapt to stress, the researchers created mice that were missing one component of the UPR. (sciencedaily.com)
  • The investigators looked at six different components in the dopamine signaling pathway and found that the obese, inactive mice had deficits in the D2 dopamine receptor. (psypost.org)
  • In TNFα-/- mice , the development of early signs of MASH and insulin resistance was significantly attenuated compared to wild-type animals . (bvsalud.org)
  • Scientists now have found that a high-fat, high-sugar diet in mouse mothers before and during pregnancy causes problems in the hearts of their offspring, and that such problems are passed down at least three generations, even if the younger generations only eat a standard mouse chow diet. (wustl.edu)
  • The scientists were astonished to find, however, that daily fluctuations in this group of lipids persist even in mice lacking a functional biological clock, albeit with levels cresting at a completely different time -- 12 hours later than the natural schedule. (sciencedaily.com)
  • The scientific team studied groups of 9-month-old lab mice who had been fed a high-fat diet for 12 weeks. (nih.gov)
  • Then, mice were divided into 5 groups. (springer.com)
  • Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1β and KC/GRO. (springer.com)
  • Tandem mass spectrometry analysis of plasma from obese mice under CR showed no difference in Cur metabolite levels between groups supplemented with Cur alone or combined with Pip. (springer.com)
  • The levels of blood glucose, triglycerides, and high-density lipoproteins for all groups of mice are not different. (peertechzpublications.com)
  • The activities of alanine transaminase and aspartate transaminase enzymes are not different among these groups of mice. (peertechzpublications.com)