Mice congenic. Medical search

Mouse strains constructed to possess identical genotypes except for a difference at a single gene locus.

Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.

Inbred C57BL mice are a strain of laboratory mice that have been produced by many generations of brother-sister matings, resulting in a high degree of genetic uniformity and homozygosity, making them widely used for biomedical research, including studies on genetics, immunology, cancer, and neuroscience.

A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.

Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.

Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.

Genetic loci associated with a QUANTITATIVE TRAIT.

Any method used for determining the location of and relative distances between genes on a chromosome.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.

Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. (1/709)

BACKGROUND: Although Fas on pancreatic islets promotes autoimmune diabetes in mice, the role of Fas expression on kidney parenchymal cells during autoimmune disease is unknown. METHODS: To determine whether Fas on renal parenchymal cells promotes autoimmune renal destruction, we compared apoptosis and pathology in Fas-intact and Fas-deficient kidneys in an autoimmune milieu. For this purpose, we transplanted single, normal kidneys from MRL-++ (Fas-intact) mice (3 months of age) into age-matched, congenic MRL-Faslpr (Fas-deficient) recipients after removal of nephritic kidneys. These Fas-intact kidneys were compared with Fas-deficient nephritic kidneys. RESULTS: There is a progressive increase of FasL on kidney-infiltrating cells and Fas and FasL on renal parenchymal cells in MRL-++ kidneys during engraftment (0, 2, 4-6, and 8 weeks). By comparison, we detected an increase in FasL in MRL-Faslpr kidneys (3 to 5 months of age), whereas Fas was not detectable. The engagement of T cells bearing FasL with Fas expressing tubular epithelial cells (TECs) induced TEC apoptosis in vitro. However, apoptosis and pathology were similar in kidneys (MRL-++, 8 weeks postengraftment vs. MRL-Faslpr, 5 months) with equivalent amounts of FasL-infiltrating cells or FasL TECs, regardless of Fas on renal parenchymal cells. CONCLUSION: The expression of Fas on renal parenchymal cells does not increase apoptosis or promote renal disease in MRL-++ mice. We speculate that the autoimmune milieu evokes mechanisms that mask, counter, or pre-empt Fas-FasL-initiated apoptosis in MRL kidneys. (+info)

The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. (2/709)

Hirschsprung disease (HSCR) is a multigenic neurocristopathy clinically recognized by aganglionosis of the distal gastrointestinal tract. Patients presenting with aganglionosis in association with hypopigmentation are classified as Waardenburg syndrome type 4 (Waardenburg-Shah, WS4). Variability in the disease phenotype of WS4 patients with equivalent mutations suggests the influence of genetic modifier loci in this disorder. Sox10(Dom)/+ mice exhibit variability of aganglionosis and hypopigmentation influenced by genetic background similar to that observed in WS4 patients. We have constructed Sox10(Dom)/+ congenic lines to segregate loci that modify the neural crest defects in these mice. Consistent with previous studies, increased lethality of Sox10(Dom)/+ animals resulted from a C57BL/6J locus(i). However, we also observed an increase in hypopigmentation in conjunction with a C3HeB/FeJLe-a/a locus(i). Linkage analysis localized a hypopigmentation modifier of the Dom phenotype to mouse chromosome 10 in close proximity to a previously reported modifier of hypopigmentation for the endothelin receptor B mouse model of WS4. To evaluate further the role of SOX10 in development and disease, we have performed comparative genomic analyses. An essential role for this gene in neural crest development is supported by zoo blot hybridizations that reveal extensive conservation throughout vertebrate evolution and by similar Northern blot expression profiles between mouse and man. Comparative sequence analysis of the mouse and human SOX10 gene have defined the exon-intron boundaries of SOX10 and facilitated mutation analysis leading to the identification of two new SOX10 mutations in individuals with WS4. Structural analysis of the HMG DNA-binding domain was performed to evaluate the effect of human mutations in this region. (+info)

Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. (3/709)

Using mice deficient for LFA-1, CD44, and ICAM-1, we examined the role of these adhesion molecules in NK1.1+TCR alpha beta+ (NKT) cell development. Although no defect in NKT cell development was observed in CD44-/- and ICAM-1-/- mice, a dramatic reduction of liver NKT cells was observed in LFA-1-/- mice. Normal numbers of NKT cells were present in other lymphoid organs in LFA-1-/- mice. When LFA-1-/- splenocytes were injected i.v. into wild-type mice, the frequency of NKT cells among donor-derived cells in the recipient liver was normal. In contrast, when LFA-1-/- bone marrow (BM) cells were injected i.v. into irradiated wild-type mice, the frequency of liver NKT cells was significantly lower than that of mice injected with wild-type BM cells. Collectively, these data indicate that LFA-1 is required for the development of liver NKT cells, rather than the migration to and/or subsequent establishment of mature NKT cells in the liver. (+info)

Evidence of alternative or concomitant use of perforin- and Fas-dependent pathways in a T cell-mediated negative regulation of Ig production. (4/709)

To study the possible involvement of perforin (Pfp)- and/or Fas-dependent cytotoxicity pathways in a T cell-mediated negative regulation of Ig production, we used the T cell-induced Ig-allotype suppression model. T splenocytes from Igha/a mice, when neonatally transferred into histocompatible Igha/b F1 or Ighb/b congenic hosts, are intrinsically able to totally, specifically, and chronically suppress the production of IgG2a of the Ighb haplotype (IgG2ab). It has not been established whether the suppression effectors, which are anti-IgG2ab MHC class I-restricted CD8+ T cells, cytolyse IgG2ab+ B targets or whether they only silence Ig production. In this study, using T cells from Igha/a Pfp+/+ or Pfpo/o mice, the latter obtained by crossbreeding, and B cells from Ighb/b Fas+/+ or Faslpr/lpr (lymphoproliferation) mice in appropriate adoptive transfer models, we demonstrated that: 1) under blockage of the Pfp-mediated pathway, Igha/a T cells were still able to induce suppression against wild-type IgG2ab+ B cells, 2) IgG2ab+ B cells with impaired Fas expression were also subjected to suppression by WT Igha/a T splenocytes, and 3) the suppression establishment was totally inhibited when both Pfp- and Fas-dependent mechanisms were simultaneously blocked, i.e., when Igha/a Pfpo/o T cells were used to induce suppression against Ighb/b Faslpr/lpr B cells. These results provide the first demonstration of the existence of alternative or simultaneous use of the major cytotoxic mechanisms in a T cell-mediated down-regulation of an Ig production. (+info)

Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus. (5/709)

Of the many minor histocompatibility (H) Ags that have been detected in mice, the ability to induce graft vs host disease (GVHD) after bone marrow transplantation is restricted to a limited number of immunodominant Ags. One such murine Ag, B6dom1, is presented by the H2-Db MHC class I molecule. We present biochemical evidence that the natural B6dom1 peptide is indistinguishable from AAPDNRETF, and we show that this peptide can be isolated from a wide array of tissues, with highest levels from the lymphoid organs and lung. Moreover, we employ a novel, somatic cell selection technique involving CTL-mediated immunoselection coupled with classical genetics, to show that B6dom1 is encoded by the H7 minor H locus originally discovered approximately 40 years ago. These studies provide a molecular genetic framework for understanding B6dom1, and exemplify the fact that mouse minor H loci that encode immunodominant CTL epitopes can correspond to classical H loci originally identified by their ability to confer strong resistance to tumor transplantation. Additionally, these studies demonstrate the utility of somatic cell selection approaches toward resolving H Ag immunogenetics. (+info)

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment. (6/709)

During positive selection, immature thymocytes commit to either the CD4+ or CD8+ T cell lineage ("commitment") and convert from short-lived thymocytes into long-lived T cells ("rescue"). By formal precursor-progeny analysis, we now identify what is likely to be the initial positive selection step signaled by alpha beta TCR, which we have termed "induction". During induction, RAG mRNA expression is downregulated, but lineage commitment does not occur. Rather, lineage commitment (which depends upon the MHC class specificity of the alpha beta TCR) only occurs after downregulation of RAG expression and the consequent fixation of alpha beta TCR specificity. We propose that positive selection can be viewed as a sequence of increasingly selective developmental steps (induction-->commitment-->rescue) that are signaled by alpha beta TCR engagements of intrathymic ligands. (+info)

A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. (7/709)

Class II transactivator (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells. Surprisingly, when CIITA-/- CD4 T cells were stimulated in the presence of IL-12, they produced not only IFNgamma but also high levels of IL-4. The IL-4 production is due to the accumulation of IL-4 gene transcripts in Th1 cells. This transcriptional control is observed in T cells differentiating to the Th1 but not Th2 lineage, consistent with induction of expression of the CIITA gene in T cells by IFNgamma. Thus, in addition to its role in transactivation of genes involved in antigen presentation, CIITA plays a critical role during the T cell differentiation by negatively regulating the IL-4 gene transcription. (+info)

c-kitUsing Ly5 congenic mice, we characterized the early differentiation step of pluripotent hemopoietic stem cells. Lineage- (Lin-)/CD71- cells in the bone marrow cells were separated into major histocompatibility complex (MHC) class I(high)/c-kit(low) and MHC class I(high)/c-kit+info)

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Congenic mice are strains that have been developed through a specific breeding process to be genetically identical, except for a small region of interest (ROI) that has been introgressed from a donor strain. This is achieved by repeatedly backcrossing the donor ROI onto the genetic background of a recipient strain for many generations, followed by intercrossing within the resulting congenic line to ensure homozygosity of the ROI.

The goal of creating congenic mice is to study the effects of a specific gene or genomic region while minimizing the influence of other genetic differences between strains. This allows researchers to investigate the relationship between genotype and phenotype more accurately, which can be particularly useful in biomedical research for understanding complex traits, diseases, and potential therapeutic targets.

Congenic animals are genetically identical organisms, except for a specific genetic locus or region that has been intentionally altered. In the context of animal research, congenic animals are created through selective breeding to transfer a particular gene or genes from one strain to another while keeping the rest of the genetic background as similar as possible.

The process involves repeatedly backcrossing the offspring of the initial cross between two strains to one of the parental strains for several generations, followed by brother-sister mating to establish a congenic strain. The resulting congenic animals share more than 99% of their genetic material with the recipient strain but carry the donor strain's gene(s) at the specific locus of interest.

Congenic animal models are essential tools in biomedical research, as they allow researchers to study the effects of a particular gene or genetic variant while minimizing the influence of other genetic factors. These models help isolate the contribution of a single gene to a phenotype, disease susceptibility, or drug response, facilitating a better understanding of complex biological processes and potential therapeutic interventions.

C57BL/6 (C57 Black 6) is an inbred strain of laboratory mouse that is widely used in biomedical research. The term "inbred" refers to a strain of animals where matings have been carried out between siblings or other closely related individuals for many generations, resulting in a population that is highly homozygous at most genetic loci.

The C57BL/6 strain was established in 1920 by crossing a female mouse from the dilute brown (DBA) strain with a male mouse from the black strain. The resulting offspring were then interbred for many generations to create the inbred C57BL/6 strain.

C57BL/6 mice are known for their robust health, longevity, and ease of handling, making them a popular choice for researchers. They have been used in a wide range of biomedical research areas, including studies of cancer, immunology, neuroscience, cardiovascular disease, and metabolism.

One of the most notable features of the C57BL/6 strain is its sensitivity to certain genetic modifications, such as the introduction of mutations that lead to obesity or impaired glucose tolerance. This has made it a valuable tool for studying the genetic basis of complex diseases and traits.

Overall, the C57BL/6 inbred mouse strain is an important model organism in biomedical research, providing a valuable resource for understanding the genetic and molecular mechanisms underlying human health and disease.

Inbred NOD (Nonobese Diabetic) mice are a strain of laboratory mice that are genetically predisposed to develop autoimmune diabetes. This strain was originally developed in Japan and has been widely used as an animal model for studying type 1 diabetes and its complications.

NOD mice typically develop diabetes spontaneously at around 12-14 weeks of age, although the onset and severity of the disease can vary between individual mice. The disease is caused by a breakdown in immune tolerance, leading to an autoimmune attack on the insulin-producing beta cells of the pancreas.

Inbred NOD mice are highly valuable for research purposes because they exhibit many of the same genetic and immunological features as human patients with type 1 diabetes. By studying these mice, researchers can gain insights into the underlying mechanisms of the disease and develop new treatments and therapies.

Mammalian chromosomes are thread-like structures that exist in the nucleus of mammalian cells, consisting of DNA, hist proteins, and RNA. They carry genetic information that is essential for the development and function of all living organisms. In mammals, each cell contains 23 pairs of chromosomes, for a total of 46 chromosomes, with one set inherited from the mother and the other from the father.

The chromosomes are typically visualized during cell division, where they condense and become visible under a microscope. Each chromosome is composed of two identical arms, separated by a constriction called the centromere. The short arm of the chromosome is labeled as "p," while the long arm is labeled as "q."

Mammalian chromosomes play a critical role in the transmission of genetic information from one generation to the next and are essential for maintaining the stability and integrity of the genome. Abnormalities in the number or structure of mammalian chromosomes can lead to various genetic disorders, including Down syndrome, Turner syndrome, and Klinefelter syndrome.

"Genetic crosses" refer to the breeding of individuals with different genetic characteristics to produce offspring with specific combinations of traits. This process is commonly used in genetics research to study the inheritance patterns and function of specific genes.

There are several types of genetic crosses, including:

1. Monohybrid cross: A cross between two individuals that differ in the expression of a single gene or trait.
2. Dihybrid cross: A cross between two individuals that differ in the expression of two genes or traits.
3. Backcross: A cross between an individual from a hybrid population and one of its parental lines.
4. Testcross: A cross between an individual with unknown genotype and a homozygous recessive individual.
5. Reciprocal cross: A cross in which the male and female parents are reversed to determine if there is any effect of sex on the expression of the trait.

These genetic crosses help researchers to understand the mode of inheritance, linkage, recombination, and other genetic phenomena.

Quantitative Trait Loci (QTL) are regions of the genome that are associated with variation in quantitative traits, which are traits that vary continuously in a population and are influenced by multiple genes and environmental factors. QTLs can help to explain how genetic variations contribute to differences in complex traits such as height, blood pressure, or disease susceptibility.

Quantitative trait loci are identified through statistical analysis of genetic markers and trait values in experimental crosses between genetically distinct individuals, such as strains of mice or plants. The location of a QTL is inferred based on the pattern of linkage disequilibrium between genetic markers and the trait of interest. Once a QTL has been identified, further analysis can be conducted to identify the specific gene or genes responsible for the variation in the trait.

It's important to note that QTLs are not themselves genes, but rather genomic regions that contain one or more genes that contribute to the variation in a quantitative trait. Additionally, because QTLs are identified through statistical analysis, they represent probabilistic estimates of the location of genetic factors influencing a trait and may encompass large genomic regions containing multiple genes. Therefore, additional research is often required to fine-map and identify the specific genes responsible for the variation in the trait.

Chromosome mapping, also known as physical mapping, is the process of determining the location and order of specific genes or genetic markers on a chromosome. This is typically done by using various laboratory techniques to identify landmarks along the chromosome, such as restriction enzyme cutting sites or patterns of DNA sequence repeats. The resulting map provides important information about the organization and structure of the genome, and can be used for a variety of purposes, including identifying the location of genes associated with genetic diseases, studying evolutionary relationships between organisms, and developing genetic markers for use in breeding or forensic applications.

Inbred strains of mice are defined as lines of mice that have been brother-sister mated for at least 20 consecutive generations. This results in a high degree of homozygosity, where the mice of an inbred strain are genetically identical to one another, with the exception of spontaneous mutations.

Inbred strains of mice are widely used in biomedical research due to their genetic uniformity and stability, which makes them useful for studying the genetic basis of various traits, diseases, and biological processes. They also provide a consistent and reproducible experimental system, as compared to outbred or genetically heterogeneous populations.

Some commonly used inbred strains of mice include C57BL/6J, BALB/cByJ, DBA/2J, and 129SvEv. Each strain has its own unique genetic background and phenotypic characteristics, which can influence the results of experiments. Therefore, it is important to choose the appropriate inbred strain for a given research question.

'Rats, Inbred Dahl' are a strain of laboratory rats that have been selectively bred for research purposes. They were first developed by Dr. Lewis L. Dahl in the 1960s at the University of Colorado School of Medicine. These rats are known for their susceptibility to develop high blood pressure (hypertension) and related cardiovascular diseases, making them a valuable model for studying hypertension and its complications.

Inbred Dahl rats are typically divided into two main strains: the Dahl Salt-Sensitive (SS/JrHsdMcwi or SS) rat and the Dahl Salt-Resistant (SR/JrHsdMcwi or SR) rat. When fed a high-salt diet, the SS rats develop severe hypertension, kidney damage, and cardiac hypertrophy, while the SR rats are relatively resistant to these effects.

The Inbred Dahl rats have contributed significantly to our understanding of the genetic and environmental factors that contribute to the development of hypertension and related disorders. They continue to be widely used in biomedical research today.

... strains are discussed in detail in Lee Silver's online book Mouse Genetics: Concepts and Applications: "Mouse Genetics ... Congenic strains are generated in the laboratory by mating two inbred strains (usually rats or mice), and back-crossing the ... Congenic mice or rats can then be compared to the pure recipient strain to determine whether they are phenotypically different ... November 1997). "Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains". Nat. Genet. 17 (3): ...

https://en.wikipedia.org/wiki/Congenic

2003). "A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density". Mamm. Genome. 13 (7): 335-40. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Hahn GV, Cohen RB, ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...

https://en.wikipedia.org/wiki/Bone_morphogenetic_protein_6

"Multiparameter analyses of spontaneous nonthymic lymphomas occurring in NFS/N mice congenic for ecotropic murine leukemia ... Rowe and his colleagues showed that retroviruses can cause leukemia in mice. He was among the first "to recognize the role of ... ISBN 978-0-323-14218-2. Rowe, W. P. (1961). "The Epidemiology of Mouse Polyoma Virus Infection". Bacteriological Reviews. 25 (1 ... Rowe, W. (1983). "Deformed whiskers in mice infected with certain exogenous murine leukemia viruses". Science. 221 (4610): 562- ...

https://en.wikipedia.org/wiki/Wallace_P._Rowe

1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". ... It is known to cause experimental disease in mouse models, suggesting that some strains could also be connected with human Lyme ...

https://en.wikipedia.org/wiki/Borrelia_lusitaniae

1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". ...

https://en.wikipedia.org/wiki/Borrelia_japonica

Selective breeding - Organisms, often mice, may be bred selectively among inbred strains to create a recombinant congenic ... most commonly mice. The recent sequencing of the genome of many species, most notably mice, has facilitated this technique. ... Genetic engineering - The genome may also be experimentally-manipulated; for example, knockout mice can be engineered to lack a ... mice, and monkeys. As a result, a critical assumption in behavioral neuroscience is that organisms share biological and ...

https://en.wikipedia.org/wiki/Behavioral_neuroscience

Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types". Journal ... In a study, researchers discovered that mice heterozygous at all MHC loci were less resistant than mice homozygous at all loci ... Yamazaki, K.; Yamaguchi, M.; Baranoski, L.; Bard, J.; Boyse, E. A.; Thomas, L. (1979). "Recognition among mice. ... such as mice, assess a mate's genetic compatibility based on their urine odor. In an experiment studying three-spined ...

https://en.wikipedia.org/wiki/Mate_choice

"Recognition among mice. Evidence from the use of a Y-maze differentially scented by congenic mice of different major ...

https://en.wikipedia.org/wiki/Mate_choice_in_humans

1985 - Started producing BALB/c mice. 1991 - Became the first commercial provider of the C.B-17 SCID mouse model. 1994 - ... Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and ... "Mice in microgravity: how rodent research in space accelerates study timelines". outsourcing-pharma.com. Retrieved 9 June 2017 ... They continue to supply NCI with BDF1 mice. 1975 - Began offering the SHR hypertensive rat and the WKY control strain. 1980 - ...

https://en.wikipedia.org/wiki/Taconic_Biosciences

November 2004). "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered ... The images and graph demonstrate that BMAT is higher in obese compared with lean mice. B6 mice were fed HFD from age 4 wk until ... August 2015). "Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice". ... August 2017). "Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice". Journal of Bone and Mineral ...

https://en.wikipedia.org/wiki/Bone_marrow_adipose_tissue

In 2016 a new knock-in mouse was generated on the C57BL/6 background to be a perfect congenic strain. This mouse, dubbed the ... For instance, leukocytes can be transferred from a CD45.1 donor mouse, into a CD45.2 host mouse, and can be subsequently ... "Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/ ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Kaplan R, Morse B, ...

https://en.wikipedia.org/wiki/PTPRC

"Know thy mouse." Science Direct. Vol. 22, No. 12, Dec. 2006, pp. 649-653. Trends in Genetics. doi:10.1016/j.tig.2006.09.010 ... inbreeding guarantees a consistent and uniform animal model for experimental purposes and enables genetic studies in congenic ... The mice that are inbred typically show considerably lower survival rates. Inbreeding increases homozygosity, which can ... In order to achieve a mouse strain that is considered inbred, a minimum of 20 sequential generations of sibling matings must ...

https://en.wikipedia.org/wiki/Inbreeding

Stanford, Lianne; Brown, Richard E. (September 2003). "MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but ... The Hebb-Williams maze is a maze used in comparative psychology to assess the cognitive ability of small animals such as mice ... The maze has been used to investigate strain and sex differences in mice. A 2018 study argued that the maze is potentially ... "Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb-Williams maze". Behavioural Brain ...

https://en.wikipedia.org/wiki/Hebb–Williams_maze

DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice ... Backcrossing Congenic strain Inbreeding Linebreeding Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, ... "The period before World War I led to the initiation of inbreeding in rats by Dr Helen King in about 1909 and in mice by Dr C. C ... Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the ...

https://en.wikipedia.org/wiki/Inbred_strain

... associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic mouse ... The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. Non-obese diabetic (NOD) mice exhibit a susceptibility ... Loss of IL-2 can thereby contribute to the development of autoimmunity in NOD mice. NOD mice have a mutation in exon 2 of the ... NOD mice have polymorphisms in the Idd3 locus which are linked to IL-2 production. IL-2 promotes either immunity or tolerance ...

https://en.wikipedia.org/wiki/NOD_mice

MeSH B01.050.157.040 - animals, congenic MeSH B01.050.157.040.500 - mice, congenic MeSH B01.050.157.520 - mice, inbred strains ... mice, congenic MeSH B01.050.199.520.520 - mice, inbred strains MeSH B01.050.199.520.520.300 - mice, inbred a MeSH B01.050. ... mice MeSH B01.150.900.649.865.635.505.500.150 - mice, congenic MeSH B01.150.900.649.865.635.505.500.400 - mice, inbred strains ... congenic MeSH B01.050.199.040.500 - mice, congenic MeSH B01.050.199.520 - animals, inbred strains MeSH B01.050.199.520.040 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)

The karyotype of the house mouse normally consists of 40 telocentric chromosomes, but in certain regions in Europe, mice with ... The associations were demonstrated by testing the responses of congenic strains differing at the H2 complex and mapping the ... Genetic mapping of the loci controlling the class I and class II antigens of the mouse showed them to be part of a cluster, ... Klein group's combined t and H2 studies on wild mice from all over the world led to the identification and characterization of ...

https://en.wikipedia.org/wiki/Jan_Klein

... "congenic", or deliberately inbred mouse strains which are histocompatible.[citation needed] An individual's immune response of ...

https://en.wikipedia.org/wiki/Passive_immunity

... rat electronic annotations from UniProt and mouse phenotype annotations from the Mouse Genome Database/Mouse Genome Informatics ... For congenic and mutant strains, genomic positions are assigned for the introgressed region (congenic strains) or the location ... Mouse QTL records, including Mammalian Phenotype (MP) ontology assignments, are imported directly from MGI. For rat and human ... Although the largest numbers of these are human and mouse cell lines, records are also available for rat, bonobo, dog, squirrel ...

https://en.wikipedia.org/wiki/Rat_Genome_Database

Using a number of recombinant and congenic rat strains, the work mapped susceptibility genes in the BB rat to the class II MHC ... Arlotta P; Tai AK; Manfioletti G; Clifford C; Jay G; Ono SJ (May 2000). "Transgenic mice expressing a truncated form of the ... Using transgenic mouse technology, they also showed (concurrently and independently of Alfredo Fusco), that fusion proteins ... can drive the development of lipomas and generate obese mice. Further contributions in the field include the mapping of the ...

https://en.wikipedia.org/wiki/Santa_Ono

In mice, ZIP12 mRNA is not detected in pancreas. In mouse Neuro-2a cells and primary mouse neurons, ZIP12 is necessary for ... identified ZIP12 as the responsible gene through congenic breeding between Fisher 344 (F344) rats, which are resistant to ... ZIP12 mRNA is more abundant in mouse oocytes compared to cumulus cells, which indicates that ZIP12 may play a role in ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: ...

https://en.wikipedia.org/wiki/Zinc_transporter_ZIP12

They had previously described the development, manufacture, and efficacy in mice of an A/Anhui/1/13 (H7N9) viruslike particle ( ... the national avian flu reference laboratory concluded that the strain of the H7N9 virus found on pigeons was highly congenic ... vaccine against H7N9 influenza is immunogenic in mice". Emerging Microbes & Infections. 2 (8): e52. doi:10.1038/emi.2013.54. ...

https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9

We used recombinant congenic mouse strains to map asthma susceptibility genes on mouse chromosome 17. Recombinant congenic ... Dissertation: Mapping of asthma susceptibility in recombinant congenic mouse strains. Promotor(s): prof. A.J.M. van Oosterhout ... Mapping of asthma susceptibility in recombinant congenic mouse strains. 04 April 2012 ... We then started to map asthma susceptibility in the Lmr series of recombinant congenic and subcongenic strains. We identified 3 ...

https://www.rug.nl/news/2012/04/13_piavaux

The Inotiv speed congenic program can shorten the generational window by reducing your breeding time by as much as 50% using as ... panels for characterizing and selecting breeders from a wide variety of inbred mouse strains used in the generation of congenic ... The Inotiv speed congenic program can shorten the generational window by reducing your breeding time by as much as 50% using as ... Inotiv also offers an animal production component to the Inotiv speed congenic program. Your colonies can be maintained in ...

https://www.inotivco.com/genetic-testing/speed-congenic-services

... produced congenic mice derived from two types of gene background, BALB/c and C57BL/6J after producing knockout mice using ES ... SOCS1 KO mice are lethal before weaning caused by anomaly of immune cells. These mice decrease lymphoid cell by facilitation of ... deficient mice. Proc. Natl. Acad. Sci. U.S.A. 95(26):15577-82. [PMID:9861011] ... cells derived from 129 strain mice (4). Were available for supply of these two lines. ...

https://animal.nibiohn.go.jp/e_socs1-kobalb.html

We have successively localized the hph-1 mutation to a congenic interval of 1.6-2.8 Mb, containing the GCH gene encoding GTP ... These new findings will extend the utility of the hph-1 mouse in studies of GTP-CH I deficiency. ... hph-1 and heterozygote mice, and found that heterozygote animals have partial tetrahydrobiopterin deficiency. ... The hph-1 ENU-mutant mouse provides a model of tetrahydrobiopterin deficiency for studying hyperphenylalaninaemia, dopa- ...

https://www.cardioscience.ox.ac.uk/publications/32772

PRNewswire/ -- The global market for mice models is expected to be evaluated at US$1.79 bn by the end of 2023. North America ... Global Mice Models Market, by Type *Transgenic Mice. *Hybrid/congenic Mice. *Knockout Mice ... Mouse breeding and re-derivation have so far been the more popular mice model service types but are likely to be replaced by ... Mice Model Market is Projected to Reach US$1.79 bn by the end of 2023; Mice Model Usage Increases in Scope through Advanced ...

https://www.prnewswire.com/news-releases/mice-model-market-is-projected-to-reach-us179-bn-by-the-end-of-2023-mice-model-usage-increases-in-scope-through-advanced-models-reports-tmr-591282461.html

By M Bosma and G Bosma, Published on 01/01/75

https://mouseion.jax.org/ssbb1975/536/

Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the ... Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the ... Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the ... Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the ...

https://keio.elsevierpure.com/en/publications/nodc3c4-congenic-mice-develop-autoimmune-biliary-disease-that-ser

... mice were injected with PBS, OVA or OVA + fucoidan. Right after 3 day remedy, splenocytes from these mice had been stained for ... Rom OT-II mice have been labeled with CFSE and transferred into CD45.1 congenic mice, and 24 hrs later, ... Rom OT-II mice have been labeled with CFSE and transferred into CD45.1 congenic mice, and 24 hrs later, mice were injected with ... Rom OT-II mice have been labeled with CFSE and transferred into CD45.1 congenic mice, and ...

https://www.bcrablinhibitor.com/2023/08/04/12341/

Liver expression of B6.C3H-6T (6T) (congenic mice with low serum IGF-1) and C57BL/6J mice. ... Liver expression of B6.C3H-6T (6T) (congenic mice with low serum IGF-1) and C57BL/6J mice ... congenic mouse is homozygous for C57BL/6J (B6) alleles across the genome except for a 30 cM region on Chr 6 that is homozygous ... in this case mouse strain, B6.C3H-6T vs. C57BL/6J). Each sample represented one mouse; no samples were pooled. No technical ...

http://churchill-lab.jax.org/website/AckertPPARG

Genetic Analysis of Skull Shape Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic ... Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic Strains between C57Bl/6 and Mice ... Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic Strains between C57Bl/6 and Mice ... To assess the genetic basis of the skull shape variation and morphological integration in mice, we have used a tool based on ...

https://complete.bioone.org/journals/evolution/volume-63/issue-10/j.1558-5646.2009.00737.x/Genetic-Analysis-of-Skull-Shape-Variation-and-Morphological-Integration-in/10.1111/j.1558-5646.2009.00737.x.short

MHC-congenic and other strains of mice can be classified according to the profiles of volatiles and microflora in their scent- ... MHC-congenic and other strains of mice can be classified according to the profiles of volatiles and microflora in their scent- ... in scent-marks produced by congenic strains of mice. The use of Consensus Principal Components Analysis is described and shows ... House mice (Mus domesticus) communicate using scent-marks, and the chemical and microbial composition of these extended ...

https://nrl.northumbria.ac.uk/id/eprint/4558/

Mice. Mice, Congenic. Mice, Inbred C57BL. Mice, Inbred NOD. Receptors, Tumor Necrosis Factor. T-Lymphocytes, Regulatory. ... Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics 2017 Mar;69(3):193- ... T1D is suppressed in NOD mice congenic for the C57BL/10 (B10)-derived Idd9 resistance region on chromosome 4. Previous studies ... where B10-derived genes suppress T1D development in NOD mice. We independently generated and characterized six congenic strains ...

https://fcd.mcw.edu/?search/showPublication/id/691570

We have evaluated the expression of IAAs in NOD mice and in diabetes-resistant NOD congenic strains to characterize the ... the prevalence of IAAs is reduced relative to NOD mice. In contrast, NOD.B10 Idd9 mice have a high prevalence of IAAs and a ... In NOD congenic strains with genes that contribute to protection from insulitis and diabetes (Idd3, Idd5, Idd10, and Idd18), ... Insulin autoantibodies (IAAs) are often present in humans for years, and in NOD mice for weeks, before the onset of diabetes. ...

https://www.ndm.ox.ac.uk/publications/1114226?cef0eb62-90bc-11ee-b2f5-0694888955de

Here, we report a study of phenotypic effects and gene interactions for 90 blood, bone, and metabolic traits in a mouse CSS ... Mice, Congenic * Mice, Inbred C57BL * Phenotype * Quantitative Trait Loci* * Rats Grants and funding * T32 GM008613/GM/NIGMS ...

https://pubmed.ncbi.nlm.nih.gov/19066216/

View mouse strain B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm : mutations, QTL, phenotypes, diseases, and references. ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse ...

https://www.informatics.jax.org/strain/MGI:6197222

Congenic strains are discussed in detail in Lee Silvers online book Mouse Genetics: Concepts and Applications: "Mouse Genetics ... Congenic strains are generated in the laboratory by mating two inbred strains (usually rats or mice), and back-crossing the ... Congenic mice or rats can then be compared to the pure recipient strain to determine whether they are phenotypically different ... November 1997). "Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains". Nat. Genet. 17 (3): ...

https://en.wikipedia.org/wiki/Congenic

Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus. Kidney Int. 2009 Feb. 75(4):366-72 ...

https://emedicine.medscape.com/article/246031-overview

Knock-out (KO) mice lacking FMRP were compared with congenic C57BL/6J wild-type (WT) controls. Input-output curves and paired- ... it appears that age does not influence LTP in APC of WT mice; LTP in Fmr1 KO mice is mostly unaffected in young mice (3-6 ... D, As in A for 8-month-old WT and KO mice. E, F, As in B and C for 16 WT and 31 KO mice aged 6-12 months. ... Animals. Male Fmr1 KO and WT mice were bred from congenic C57BL/6J stock obtained from The Jackson Laboratory (Bar Harbor, ME ...

https://www.jneurosci.org/content/25/41/9460

... central nervous system trafficking was independent of neuro-inflammatory signals as it occurred in MIS416-treated healthy mice ... d,e) CFSE-labelled 2D2 cells were transferred to congenic mice (CD45.1) one day before MIS416 treatment and EAE immunization. ... mouse anti-FoxP3 IgG1, mouse anti-CX3CR1 IgG2a, and mouse anti-CD45.1 IgG2a from Biolegend (San Diego, CA) and rat anti-CD4 ... showed that PD-L1−/− mice have enhanced T cell responses in vitro and develop more severe EAE than wild type mice26. In ...

https://www.nature.com/articles/s41598-017-18543-z?error=cookies_not_supported&code=2a32c8c1-3848-41d3-8de1-b725dc246a8e

In an early congenic mouse melanoma model [95], the OVA-expressing B16F10 cell line MO-4 was used. Bone marrow-derived DCs ( ... In a mouse model of malaria where mice were challenged with infected erythrocytes of Plasmodium berghei transgenic for the ... in a pivotal mouse study, ovalbumin (OVA) preincubated with anti-OVA IgG was taken up much more efficiently by splenic mouse ... Importantly, in mice transplanted with OVA-specific CD8+ or CD4+ T cells, OVA:IgG ICs induced both CD4+ and CD8+ T-cell ...

https://www.mdpi.com/2076-393X/9/4/409

Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57BL/6J strain, the Ahl locus has been ... The present study was designed to test these congenic strains for their vulnerability to noise-induced hearing loss. Mouse ... This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. This ... identified a single genetic locus (Ahl) that could explain the early presbycusis observed in the inbred C57BL/6J mouse strain. ...

http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=noise+&f1=TI&Startyear=&t1=0&s2=hearing+loss&terms=3&Adv=1&ct=&B1=Search&f2=TI&Limit=500&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=7&RecNo=70&View=f&

Further, "SOD1 mouse models of disease, especially on congenic backgrounds, appear to be quite sensitive to environmental ... at least one mouse mutant line for every gene in the mouse genome over the next 20 years. The total number of mice that are ... Working with mice as an in vivo model to phenocopy the disease, mice stem cells are bred "to have either the normal human SOD ... "Transgenic mutant SOD1 mice are the only ALS mouse models currently available that exhibit all of the histopathological ...

https://www.erudit.org/en/journals/ateliers/2013-v8-n1-ateliers0812/1018334ar/

The p16-3MR mouse model was created and backcrossed to C57BL/6J (000664) using a "speed congenic" approach. If you have a ... Measuring frailty in mice to examine aging. Vivek Kumar is using machine learning and computational science to examine frailty ... Double p16 (Cdkn1a)/p21(Cdkn2a) knockout mice could be generated using some of these JAX strains: *B6.129S6(Cg)-Cdkn1atm1Led/J ... both a comprehensive Speed Congenic Service as well as a Genome Scanning Service to assist you with backcrossing your mice at ...

https://www.jax.org/news-and-insights/2015/February/cellular-senescence-an-unexpected-advantage-in-wound-healing

Immunogenicity threshold affects the CTL responses to the linked nonimmunogenic and subdominant Ags.Congenic marker Ags are ... Mice referred to as CD45.1/2 129B6 are B6 Ly5.1 mice crossed with 129 mice. The OTI mice were bred in-house. Prior to ... Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment ... 5B, B10 CD45.2 mice were crossed to B6-CD45.2 mice to create B6/B10 CD45.2 mice. B6-CD45.2 females (recipients) were immunized ...

https://journals.aai.org/jimmunol/article/211/11/1623/266095/Immunogenicity-Threshold-in-Allogeneic-Cells

... of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic ... 3I,L, 4A,B, red) increased the predicted threshold for three CamKIIa-ChR2 mice, but decreased it for two mice. There was no ... Indeed, light presentation alone did not affect the startle response (PV-ChR2 mice, blue light: n = 11, p , 0.05; PV-Arch mice ... All experiments were performed in adult male mice (The Jackson Laboratory; age 12-15 weeks; weight 22-32 g; PV-Cre mice, strain ...

https://www.jneurosci.org/content/38/8/2094.full

A mouse model of papillomavirus infection reveals that skin colonization with commensal papillomaviruses protects the ... Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune ... mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a ... we colonized several strains of immunocompetent mice with mouse papillomavirus type 1 (MmuPV1)5. ...

https://www.nature.com/articles/s41586-019-1719-9?error=cookies_not_supported&code=61ff6cff-0e9d-4d7b-8119-bc2b71208e57

These mice were backcrossed for 10 generations to C57BL/6J mice to generate the congenic line, C57BL/6J-Bcar3tm1Lern. Further, ... founder mice were backcrossed to 129 mice to immediately establish genetically homogeneous mice or backcrossed to C57BL/6J mice ... AND-34−/− mice undergo postnatal lens rupture. During general maintenance of the mouse colony, it was noted that some mice had ... AND-34−/− mice have few phenotypic abnormalities. AND-34−/− mice were initially observed to be healthy and without overt signs ...

http://www.molvis.org/molvis/v15/a70/

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations ... Mouse strains utilized in the experiments were: CB.17 SCID mice for subQ xenografts relative to A375, Colo205, and A375 NRAS; ... D, Individual BLI signals from the mice of the same study on study days 6, 13, 20, and 27. E and F, Brain micrometastatic ... D, Individual BLI signals from the mice of the same study on study days 6, 13, 20, and 27. E and F, Brain micrometastatic ...

https://aacrjournals.org/clincancerres/article/28/4/770/678091/Preclinical-Characterization-of-a-Next-Generation

Three to five R1.P1-Apoa2c congenic mice were housed in a single cage. Female mice were used for experiments to avoid the ... R1.P1-Apoa2c congenic mice were used in this study, which carry the amyloidogenic type c allele (Apoa2c) of amyloidosis- ... Apolipoprotein A-II gene and development of amyloidosis and senescence in a congenic strain of mice carrying amyloidogenic ApoA ... e) Mice in curcumin-supplemented group have larger livers and less adipose tissue in the abdominal cavity than mice without ...

https://elifesciences.org/articles/63538

We used recombinant congenic mouse strains to map asthma susceptibility genes on mouse chromosome 17. (rug.nl)
Recombinant congenic strains are series of strains which have inherited one or more chromosomal fragments from a donor strain and all other DNA from the background strain. (rug.nl)
We then started to map asthma susceptibility in the Lmr series of recombinant congenic and subcongenic strains. (rug.nl)
Alteration of ig expression in congenic mouse strains. (jax.org)
To assess the genetic basis of the skull shape variation and morphological integration in mice, we have used a tool based on the cross between the distantly related mouse species Mus spretus (SEG/Pas strain) and the laboratory strain C57BL/6 called interspecific recombinant congenic strains (IRCSs). (bioone.org)
This study examined how the genes of the major histocompatibility complex (MHC) and background genes influence the volatile compounds (analysed with Gas Chromatography Mass Spectrometry or GC/MS) and microbial communities (analysed using Denaturating Gradient Gel Electrophoresis or DGGE) in scent-marks produced by congenic strains of mice. (northumbria.ac.uk)
As expected, the differences among the mice were much greater between strains that vary at both MHC and background loci than the congenics, which differ only at the MHC. (northumbria.ac.uk)
We independently generated and characterized six congenic strains containing B10-derived intervals that partially overlap with the Idd9.1 and Idd9.4 regions. (mcw.edu)
We have evaluated the expression of IAAs in NOD mice and in diabetes-resistant NOD congenic strains to characterize the association of autoantibody expression with insulitis and diabetes. (ox.ac.uk)
In NOD congenic strains with genes that contribute to protection from insulitis and diabetes (Idd3, Idd5, Idd10, and Idd18), the prevalence of IAAs is reduced relative to NOD mice. (ox.ac.uk)
These data indicate that IAA expression is a phenotype that is associated with insulitis and correlates with overall disease progression in some strains of congenic mice but not in others. (ox.ac.uk)
Congenic strains are generated in the laboratory by mating two inbred strains (usually rats or mice), and back-crossing the descendants 5-10 generations with one of the original strains, known as the recipient strain. (wikipedia.org)
Susceptibility to noise -induced hearing loss in two congenic mouse strains. (cdc.gov)
Recently, Johnson has developed two relevant congenic mouse strains. (cdc.gov)
This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous inbred C57BL/6J and CBA/CaJ data. (cdc.gov)
To investigate the effects of papillomavirus on carcinogen-driven skin cancer, we colonized several strains of immunocompetent mice with mouse papillomavirus type 1 (MmuPV1) 5 . (nature.com)
2009 ). Strikingly, two congenic mouse strains in which the Prdm9 alleles have different zinc finger arrays show completely distinct sets of hotspots (Brick et al. (springer.com)
Actually in my reply I totally forgot to mention that the most promising way to test for the restriction element is to use congenic MHC recombined mouse strains. (bio.net)
To look for mice strains with recombinant MHCs take a look at the article of Klein-J, Immunogenetics, I think Vol. 17, around page 700. (bio.net)
Several functional studies have reported that the Ahl gene renders mice more susceptible to noise-induced hearing loss (NIHL) than strains which do not carry this gene [e.g. (cdc.gov)
Non-noise-exposed mice of the same strains and age served as controls. (cdc.gov)
The Ghent researchers looked through the sequences for differences between Black 6 mice and the 129 strains that would affect protein production. (the-scientist.com)
Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. (gentaur.com)
Common laboratory inbred mouse strains such as BALB/c and C57Bl6/J form the backbone of much of our pre-clinical work. (ncard.org.au)
Immunodeficient mouse strains are invaluable when assessing the role of immune cell subsets in anti‑tumour immunity. (ncard.org.au)
The use of recombinant inbred (RI) and congenic mouse strains for genetic and biochemical studies of audiogenic seizures is presented. (elsevierpure.com)

Faculty of Medicine, Osaka University) produced congenic mice derived from two types of gene background, BALB/c and C57BL/6J after producing knockout mice using ES cells derived from 129 strain mice (4). (go.jp)
C57BL/6 mice have been immunized with PBS, OVA, fucoidan or OVA + fucoidan on days 0, 15 and 30. (bcrablinhibitor.com)
plosone.orgFucoidan Functions as an Adjuvant In Vivotransgenic mice and C57BL/6-Ly5.1 (CD45.1) congenic mice were obtained from Shanghai Public Wellness Clinical Center, and kept below pathogen-free conditions. (bcrablinhibitor.com)
The B6.C3H-6T (6T) congenic mouse is homozygous for C57BL/6J (B6) alleles across the genome except for a 30 cM region on Chr 6 that is homozygous for C3H/HeJ (C3H) alleles. (jax.org)
The experimental design of this experiment was a simple two-factor experiment, with three biological replicates of each factor (in this case mouse strain, B6.C3H-6T vs. C57BL/6J). (jax.org)
T1D is suppressed in NOD mice congenic for the C57BL/10 (B10)-derived Idd9 resistance region on chromosome 4. (mcw.edu)
Knock-out (KO) mice lacking FMRP were compared with congenic C57BL/6J wild-type (WT) controls. (jneurosci.org)
Female C57BL/6, B6.SJL-ptprca, 2D2 (MOG 35-55 TCR transgenic) 6 , and IFN-γ-deficient mice between the ages of 8-12 weeks old were obtained from the Malaghan Institute of Medical Research. (nature.com)
identified a single genetic locus (Ahl) that could explain the early presbycusis observed in the inbred C57BL/6J mouse strain. (cdc.gov)
In the congenic C57BL/6J strain, the Ahl locus has been replaced by the wild-type locus from the inbred CBA/CaJ strain (strain B6.CBA). (cdc.gov)
The p16-3MR mouse model was created and backcrossed to C57BL/6J ( 000664 ) using a "speed congenic" approach. (jax.org)
The CIEA NOG mouse ® was developed by backcrossing the C57BL/6JJic-Il2rg line to the NOD/ShiJic-Prkdc scid line for a total of eight generations. (taconic.com)
Inbred C57BL/6J mice carry two copies of an age-related hearing loss gene (Ahl). (cdc.gov)
The congenic B6.CAST-+Ahl male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not less PTS or hair-cell losses at 20 days post-exposure. (cdc.gov)
Particularly repeated sibling interbreedings of mice having the transgene over the C57BL/6 hereditary background result in progressive adjustments in the appearance design of transgenes in the locus that no more Triacsin C reflects endogenous appearance. (exposed-skin-care.net)
METHODS: As renal phenotype can be influenced by genetic background, we generated congenic C57BL/6 and FVB/N Ctns(-/-) mice and assayed renal lesions and function by histological and biochemical studies. (cnrs.fr)
RESULTS: C57BL/6 Ctns(-/-) mice showed significantly higher renal cystine levels than the FVB/N strain. (cnrs.fr)
Moreover, C57BL/6 mice presented with pronounced histological lesions of the proximal tubules as well as a tubulopathy and progressively developed chronic renal failure. (cnrs.fr)
CONCLUSIONS: Thus, the C57BL/6 strain represents the first Ctns(-/-) mouse model to show clear renal defects. (cnrs.fr)
In addition to highlighting the influence of genetic background on phenotype, the C57BL/6 Ctns(-/-) mice represent a useful model for further understanding cystinosin function in the kidney and, specifically, in the proximal tubules. (cnrs.fr)
Congenic BALB/c CL4 strain expressing C57Bl/6 Thy 1.1 allele. (ncard.org.au)

We have successively localized the hph-1 mutation to a congenic interval of 1.6-2.8 Mb, containing the GCH gene encoding GTP cyclohydrolase I (GTP-CH I). We used these data to establish a PCR method for genotyping wild type, hph-1 and heterozygote mice, and found that heterozygote animals have partial tetrahydrobiopterin deficiency. (ox.ac.uk)
Unlike congenic organisms, coisogenic organisms cannot be bred and only occur through spontaneous or targeted mutation at the locus. (wikipedia.org)
If you have a mutation that you would like to transfer to a different genetic background, JAX offers both a comprehensive Speed Congenic Service as well as a Genome Scanning Service to assist you with backcrossing your mice at your facility. (jax.org)
The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. (taconic.com)
BALB/c nude mice: A spontaneous mutation in Foxn1 nu induces abnormal hair growth (nude phenotype). (ncard.org.au)
Mice homozygous for the Rag1 tm1Mom mutation produce no mature T cells or B cells. (ncard.org.au)
Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironmentsevere combined immune deficient phenotype on Non obese diabetic genetic background. (ncard.org.au)
Here, in mice carrying pathogenic C5024T in mt-tRNAAla and in patients with mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS) syndrome carrying A3243G in mt-tRNALeu, we found memory T and B cells to have lower pathogenic mtDNA mutation burdens than their antigen-inexperienced naive counterparts, including after vaccination. (bvsalud.org)

We previously identified a Quantitative Trait Locus (QTL) for Bone Mineral Density (BMD) on mouse Chromosome (Chr) 6 that overlaps a QTL for serum IGF-1. (jax.org)
In genetics, two organisms that differ in only one locus and a linked segment of chromosome are defined as congenic. (wikipedia.org)
As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)

Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. (elsevierpure.com)
Congenic mice or rats can then be compared to the pure recipient strain to determine whether they are phenotypically different if selection was for a genotypic region, or to identify the critical genetic locus, if selection was for a phenotype. (wikipedia.org)
In the congenic CBA/CaJ strain the wild-type locus has been replaced by the mutant Ahl locus (strain CBA.B6). (cdc.gov)
This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. (cdc.gov)
114 (1997) 83] developed a congenic B6.CAST-+Ahl mouse which carries the wild-type allele from Mus musculus castaneus at the Ahl locus. (cdc.gov)
Significantly by mating mice using the aberrant transgene appearance design onto different hereditary backgrounds the recombination design that recapitulates the appearance design from the endogenous hereditary locus could be reestablished. (exposed-skin-care.net)
Outcomes The hereditary locus exhibits adjustable activity that depends upon hereditary Triacsin C background and it is mixed up in developing germline and mice had been generated on the history (Franco et al. (exposed-skin-care.net)
Amount 1 The hereditary locus exhibits adjustable activity that depends upon hereditary history To facilitate maintenance of the lines for regular shipments we produced homozygous or mice. (exposed-skin-care.net)
Sparse") that spanned all neocortical cell levels similarly (Fig. 1B E). This is in stark comparison to the appearance design from the endogenous hereditary locus as well as the recombination design in mice which were not really preserved by mating homozygous littermates (Fig. 1A) (Franco et al. (exposed-skin-care.net)

Likewise, p16/p21 double knockout mice, which have very few senescent cells, showed similar delays in wound closure. (jax.org)
Notably, genetic deletion of Na V 1.1 in sensory neurons caused profound and visible motor coordination deficits in conditional knockout mice of both sexes, similar to conditional Piezo2-knockout animals, suggesting that this channel is a major contributor to sensory proprioceptive transmission. (elifesciences.org)
Impressively, recordings from afferents of heterozygous conditional knockout animals were similarly impaired, and heterozygous conditional knockout mice also exhibited motor behavioral deficits. (elifesciences.org)
Using pharmacology, gene knockout, behavior, and histology in mice, the authors show quite convincingly that Na V 1.1 in sensory neurons is essential for normal motor behavior and contributes to proprioceptor excitability. (elifesciences.org)
Knockout and other transgenic mice are traditionally made by genetically modifying embryonic stem cells (ESCs) in a dish and then inserting them into a recipient mouse embryo. (the-scientist.com)
That's because, according to a 1995 study and subsequent work, Casp1 knockout mice did not go into septic shock when challenged with molecules signaling foreign invaders. (the-scientist.com)
However, in 2011, researchers at Genentech showed that many Casp1 knockout mice also harbored a mutated Casp11 gene from 129 strain mice. (the-scientist.com)
This result triggered Vanden Berghe and his colleagues to look into their own work with Casp3 knockout mice. (the-scientist.com)
Researchers can genetically modify Black 6 mice using Black 6 ESCs, or they can use CRISPR/Cas to make knockout mice in just about any background. (the-scientist.com)

Previous studies conducted by other investigators have identified four subregions (Idd9.1, Idd9.2, Idd9.3, and Idd9.4) where B10-derived genes suppress T1D development in NOD mice. (mcw.edu)
Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
They found that 1,084 genes in 129 strain mice have insertions, deletions, or single-nucleotide mutations that cause them to diverge in sequence from Black 6 mice. (the-scientist.com)

Rom OT-II mice have been labeled with CFSE and transferred into CD45.1 congenic mice, and 24 hrs later, mice were injected with PBS, OVA or OVA + fucoidan. (bcrablinhibitor.com)
Consequently, we further explored 1) under what circumstances does the congenic marker CD45.1 provoke immunity in CD45.2 mice, and 2) whether linking two dominant or subdominant Ags can instigate an immune response. (aai.org)

This mouse was created to study biology behind both the BMD and the serum IGF-1 QTLs and to identify the gene(s) underlying these QTLs. (jax.org)
The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
These results indicate that, at one month of age, mice carrying two copies of the Ahl gene have an increased susceptibility to TTS from a low-frequency noise before they have any indication of age-related hearing or hair-cell loss. (cdc.gov)
When researchers compare their modified mice to control Black 6 mice, they may observe phenotypic differences that result from passenger mutations in 129 mouse DNA, rather than from changes to their actual gene of interest, according to the Ghent team. (the-scientist.com)
Df1 /+ mice have a multi-gene deletion analogous to the chromosomal microdeletion that causes human 22q11.2DS, and like human 22q11.2DS patients exhibit high rates of hearing loss arising primarily from susceptibility to middle ear inflammation. (biorxiv.org)
When crossed to different Cre reporter lines Triacsin C on the congenic history mice regularly exhibited a recombination design that recapitulated the upper-layer biased appearance design from the endogenous gene (Fig. 1A). (exposed-skin-care.net)
TAg phenocopies loss of the tumour suppressor gene p16 and thus MexTAg mice reliably develop mesothelioma, but only after asbestos exposure (PubMed Refs 17108115 , 20850297 , 26680231 ). (ncard.org.au)

Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a defined triple-helical epitope on collagen type-II (COL2), constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans. (bvsalud.org)
The following animal models are presently characterized: Akita mouse model, IGF-II/LDLR-/-ApoB100/100 mouse, BB/DR.LepR-/- congenic rats, PDGFBret/ret mouse (a.k.a. retention mouse), ZSF1 rats, DIO mouse, SUR1/E1506K x LDLR-/-ApoB100/100. (lu.se)

Susceptibility to diabetes in humans and nonobese diabetic (NOD) mice is believed to arise from the combined effect of multiple genetic loci, resulting in immune-mediated destruction of the insulin-secreting beta-cells. (ox.ac.uk)
Fmr1 KO mice exhibit hyperactivity in open field tests, heightened seizure susceptibility, exaggerated responses to sensory stimulation, normal fear conditioning, and mild impairments in spatial learning tasks ( Kooy, 2003 ). (jneurosci.org)
Here, we used the Df1 /+ mouse model of 22q11.2DS to investigate the relationship between hearing loss and susceptibility to schizophrenia-relevant brain and behavioral abnormalities. (biorxiv.org)

We tested whether modulation of inhibition or excitation in the auditory cortex of male mice could evoke such a variety of effects in tone-evoked responses and in behavioral frequency discrimination acuity. (jneurosci.org)
Please note that advanced order placement is encouraged for male mice. (taconic.com)
Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)

CD4 TCR transgenic mouse whose CD4 T cells predominantly recognise the MHC class II (I‑A d )‑restricted TCR specific for the PR8 influenza HA peptide 126-138 (HNTngvtaacshe) ( PMID: 7889402 ). (ncard.org.au)

Platform Affymetrix GeneChip Mouse Genome 430 2.0 Array. (jax.org)
Passenger mutations affect experiments using transgenic animals models called congenic mice, whose modified genetic material comes from a different genetic background than the rest of their genome. (the-scientist.com)

Cell populations derived from these transgenic mice can be distinguished from syngeneic host and other mice with the alternate allele via flow cytometry. (ncard.org.au)

AND-34 −/− mice were generated by homologous recombination. (molvis.org)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
Since 129 strain mice are difficult to breed, researchers typically transfer their ESCs into the embryos of Black 6 mice and then repeatedly backcross the animals with Black 6 mates while selecting for their 129 strain-derived transgene, slowly eliminating 129 strain DNA surrounding the transgene through recombination. (the-scientist.com)
People don't realize that recombination occurs very infrequently and that you're going to end up with this chunk of DNA from one strain on the background of the other," said Jake Lusis , who studies mouse genetics and cardiovascular and metabolic disorders at the University of California, Los Angeles, and was not involved in the study. (the-scientist.com)
We present which the recombination design in mice depends upon hereditary background and mating strategies. (exposed-skin-care.net)
2012 We observed this shifted recombination design with increasing frequency and magnitude upon extended inbreeding of mice. (exposed-skin-care.net)

Herein we demonstrate that NOD.c3c4 mice congenically derived from the nonobese diabetic strain develop an autoimmune biliary disease (ABD) that models human PBC. (elsevierpure.com)
The nonobese diabetic (NOD) mouse develops spontaneous T1D and has been used extensively to study the genetic control of this disease. (mcw.edu)

The transformed cells are, however, all oncogenic in the host animal and in immunocompetent mice. (microbiologyresearch.org)

Genetically engineered mice is expected to be the leading service by 2023. (prnewswire.com)
Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes. (the-scientist.com)

The hph-1 ENU-mutant mouse provides a model of tetrahydrobiopterin deficiency for studying hyperphenylalaninaemia, dopa-response dystonia, and vascular dysfunction. (ox.ac.uk)
By using congenic or mutant mice and wild-type versus genetically engineered viruses, we examined the consequences on antiviral CD8 T cell responses of specific defects in the ability of the NK cells to control MCMV. (uni-muenchen.de)

However, our previous study in mice showed that linked nonimmunogenic Ags (OVA and GFP) containing immunodominant peptides mount immunity irrespective of the MHC-matched allogeneic cell's immunogenicity. (aai.org)
Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a manner dependent on CD8 + T cells. (nature.com)
homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. (ncard.org.au)

Furthermore, NOD.c3c4- scid mice develop disease after adoptive transfer of splenocytes or CD4 + T cells, demonstrating a central role for T cells in pathogenesis. (elsevierpure.com)
Fukuchi Y, Miyakawa Y, Kobayashi K, Kuramochi T, Shimamura K, Tamaoki N, Nomura T, Ueyama Y, Ito M. (1998) Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice. (taconic.com)

House mice (Mus domesticus) communicate using scent-marks, and the chemical and microbial composition of these 'extended phenotypes' are both influenced by genetics. (northumbria.ac.uk)

Notably mice attained with the Chen lab originally originated from colonies which were preserved for over 10 years (>3 years) by interbreeding mice homozygous for the transgene which we present here impacts the Cre appearance design. (exposed-skin-care.net)
Mice which were eventually obtained with the Chen lab were preserved for a lot more than 10 years of interbreeding inside our homozygous colony. (exposed-skin-care.net)

These results identify the NOD.c3c4 mouse as the first spontaneous mouse model of PBC. (elsevierpure.com)
These disorders in mice include audiogenic seizures, the epilepsy (El) mouse, various spontaneous seizures, the tottering/leaner syndrome, seizures associated with cerebellar abnormalities, seizures associated with myelin disorders, and alcohol withdrawal seizures. (elsevierpure.com)

ELISA Enzyme-linked immunosorbent assays Code 90320007 SNOMED, Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. (gentaur.com)

Insulin autoantibodies (IAAs) are often present in humans for years, and in NOD mice for weeks, before the onset of diabetes. (ox.ac.uk)
In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
In this chapter, we review the major inherited convulsive disorders found in mice and discuss their possible relationship to specific clinical seizure disorders in humans. (elsevierpure.com)
We find that for most major types of epilepsy in humans, there exists a similar counterpart in the mouse. (elsevierpure.com)

Input-output curves and paired-pulse plasticity were not significantly altered in KO compared with WT mice in either the olfactory cortex or hippocampus. (jneurosci.org)
Postsynaptic responses to patterned burst stimulation in KO mice showing impaired LTP were not significantly different from those in WT mice, suggesting that the LTP deficit was not caused by alterations in circuit properties. (jneurosci.org)
Moreover, PV+ inhibitory interneurons, another marker for schizophrenia pathology, were significantly reduced in density in auditory cortex but not secondary motor cortex of Df1 /+ mice with hearing loss. (biorxiv.org)

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. (mcw.edu)
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. (ox.ac.uk)
In contrast, NOD.B10 Idd9 mice have a high prevalence of IAAs and a high degree of insulitis, despite a nearly complete resistance to diabetes. (ox.ac.uk)

mouse: an excellent recipient mouse model for engraftment of human cells. (taconic.com)

A 3-component transgenic mouse model to track and manipulate senescent cells in vivo . (jax.org)
In their study, the Campisi team developed a transgenic mouse model to label and eliminate cells undergoing cellular senescence. (jax.org)
CD8 TCR transgenic mouse whose CD8 T cells predominantly recognise the MHC class I (H-2K d ) restricted CL4 epitope of PR8 influenza HA protein. (ncard.org.au)

The CIEA NOG mouse ® was developed by Mamoru Ito of the Central Institute for Experimental Animals (CIEA) in Japan. (taconic.com)

BALB/cJ : a commonly used inbred mouse stain. (ncard.org.au)
BALB/c based mouse model in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Treg) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. (ncard.org.au)

These mice decrease lymphoid cell by facilitation of apoptosis though differentiation of lymphocytes in thymus or spleen is normal. (go.jp)

All information are from analyses of 6 person mice every single group (two mice per experiment, total 3 independent experiments). (bcrablinhibitor.com)
All data are representative of or the average of analyses of 5 independent samples (two or 3 mice per experiment, total two independent experiments). (bcrablinhibitor.com)
The protocol was authorized by the committee on the Ethics of Animal Experiments of your Shanghai Public Health Clinical Center (Mouse Protocol Nu. (bcrablinhibitor.com)
FLICKR, STEFANO Passenger mutations-unwanted alterations that accompany intentional genetic modifications-can confound experiments using certain types of transgenic mice. (the-scientist.com)
Experiments using transgenic mice have provided perhaps the strongest evidence for a direct role by HIV type 1 (HIV-1) in the development of HIV-associated nephropathy (HIVAN). (medscape.com)

While AND-34 is widely expressed in wild type mice, histologic analysis of multiple organs in AND-34 −/− mice is unremarkable and analyses of lymphocyte development show no overt changes. (molvis.org)
wild-type mice routinely. (exposed-skin-care.net)

Indeed, the same optogenetic manipulation in the auditory cortex of different mice could improve or impair frequency discrimination acuity, predictable from the effects on cortical responses to tones. (jneurosci.org)
Moreover, we report a reduction in density of PV+ inhibitory interneurons in the auditory cortex, but not secondary motor cortex, of Df1 /+ mice with hearing loss. (biorxiv.org)

Affected areas of biliary epithelium are infiltrated with CD3 + , CD4 + , and CD8 + T cells, and treatment of NOD.c3c4 mice with monoclonal antibody to CD3 protects from ABD. (elsevierpure.com)
Here, we have expressed monoclonal ACPAs derived from patients with RA, and analyzed their functions in mice, as well as their specificities. (bvsalud.org)

The 5 atypical BSE-H isolates by analyzing their molecular apparent molecular masses and relative quantities of these and neuropathologic properties during transmission in glycoforms are used in biochemical PrPres typing as the transgenic mice expressing homologous bovine prion criteria to differentiate between prion diseases. (cdc.gov)

On the other hand, Li and colleagues ( 2002 ) found that synaptic potentials recorded in layer IV/V of frontal neocortex in response to white matter stimulation showed greatly diminished LTP in Fmr1 KO mice. (jneurosci.org)

New mice models are found to be acceptable in the studies of advanced diseases, a fact which is greatly driving the demand for mice models. (prnewswire.com)
To understand how senescent cells promote repair, the Campisi team surveyed wound sites in GCV-treated p16-3MR mice and found fewer endothelial cells and fibroblasts, including myofibroblasts, which are contractile cells responsible for wound closure. (jax.org)
Sizable variation in the magnitude of TTS, PTS and hair-cell loss was found among mice of the same genetic strain. (cdc.gov)
We found that hearing loss in Df1 /+ mice affected schizophrenia-relevant endophenotypes, including electrophysiological measures of central auditory gain and behavioral measures of auditory sensorimotor gating. (biorxiv.org)

The hIL-2 NOG mouse was developed by microinjecting a transgene consisting of a DNA fragment containing human IL-2 cDNA under the control of the CMV promoter into zygotes of NOD/ShiJic-Il2rg mice. (taconic.com)
The ideal result is an almost entirely Black 6 mouse with a 129 strain transgene. (the-scientist.com)
Specifically, 129 strain congenic mice on a Black 6 background that have been backcrossed for 10 generations have more than a 90 percent chance of having around 1 million base pairs of 129 strain DNA on either side of the transgene. (the-scientist.com)

The mice developed proteinuria and had a histologic picture similar to that observed in patients with HIVAN. (medscape.com)

Super immunodeficient NOG mouse expressing human IL-2 cytokine. (taconic.com)
NCARD uses a variety of immunodeficient mice, which are mostly sourced from commercial vendors. (ncard.org.au)

The ALS Association had recently shown the use of mutated mice models for the study of the disease," states a TMR analyst. (prnewswire.com)
Whilst IFN-γ is typically considered to be a pro-inflammatory product of effector T cells, it has been also been demonstrated that IFN-γ −/− mice develop more severe EAE than wild type (WT) controls 5 , highlighting alternate, IFN-γ-dependant negative feedback mechanisms that can constrain EAE disease activity. (nature.com)

The adjuvant function of fucoidan is going to be potentially helpful for tumor vaccines.Components and Methods Mice and cell linesC57BL/6 mice (6 weeks old) were purchased in the B K Laboratory Animal Corp (Shanghai). (bcrablinhibitor.com)

Classification methods including Support Vector Machines and Discriminant Partial Least Squares suggest that mice can be classified according to both background strain and MHC-haplotype. (northumbria.ac.uk)

Mouse breeding and re-derivation have so far been the more popular mice model service types but are likely to be replaced by genetically engineered models soon. (prnewswire.com)
Inbred mice models have consistently been the more popular mice model types. (prnewswire.com)
This is only one of the many examples that can show that the recent advancements in mice model types and services have not only added to the strength of existing research processes, but have also expanded the scope of mice model use within other medical research fields. (prnewswire.com)
The integral nature of the mice model market with the pharmaceutical and biomedical fields has allowed companies from these industries to form alliances that can even revolve around further advancing the mice models types and services in the future. (prnewswire.com)
The information presented in this review is based on a Transparency Market Research report, titled, "Mice Model Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023. (prnewswire.com)
Synaptic function and plasticity were studied in mice lacking the fragile X mental retardation protein (FMRP), a model for the fragile X mental retardation syndrome. (jneurosci.org)
To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. (elifesciences.org)
In the Df1 /+ mouse model of human 22q11.2 Deletion Syndrome, we find that hearing loss shapes measures that are considered schizophrenia-relevant endophenotypes, such as central auditory gain and auditory sensorimotor gating. (biorxiv.org)
Asbestos induced mesothelioma mouse model in which expression of the Simian Virus 40 large T antigen (SV40 TAg) is controlled by mesothelin tissue‑specific promoter. (ncard.org.au)

Right after 3 day remedy, splenocytes from these mice had been stained for CD45.two to identify the donor OT-I or OT-II cells along with the H3 Receptor Antagonist web proliferation of those cells was determined by CFSE dilution. (bcrablinhibitor.com)

Until recently, these cells almost always came from 129 strain mice, a group of substrains of mice that produce ESCs that are unusually robust and easy to manipulate. (the-scientist.com)

SOCS1 KO mice are lethal before weaning caused by anomaly of immune cells. (go.jp)
Immunization with OVA and fucoidan protects mice from challenge with B16-OVA tumor cells. (bcrablinhibitor.com)
On day 35 of immunization, the mice had been challenged s.c. with 16106 B16-OVA (melanoma) tumor cells. (bcrablinhibitor.com)
D) On day 35, in vivo killing of adoptively transferred SIINFEK-coated and CFSE-labeled target cells by CTLs in the immunized mice was measured. (bcrablinhibitor.com)
Using these p16-3MR mice and in vivo bioluminescent imaging, the researchers observed a robust, but transient, increase in senescent cells at the site of cutaneous injury. (jax.org)
Scar tissue (stained for collagen, in orange) is evident in healed wounds from transgenic p16-3MR mice lacking senescent cells (bottom panel, GCV-treated) compared to control mice (top panel, PBS-treated). (jax.org)
Both GIMAP4 and GIMAP7 from human Jurkat cells [ 3 ] localize to the endoplasmic reticulum and Golgi apparatus while mouse Gimap3 from murine IL-3-dependent 32D myeloid precursor cells was expressed at the outer mitochondrial membrane [ 15 ]. (hindawi.com)
Predominant differentiation of human NK cells following human HSC engraftment, with>10-fold higher CD56+ NK cell numbers compared to the base NOG mouse. (taconic.com)
Human NK cells developed in hIL-2 NOG mice express various NK receptors and produce both granzyme A and perforin upon stimulation. (taconic.com)
Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
To address this question, we took advantage of the well-defined molecular interactions involved in the recognition of mouse cytomegalovirus (MCMV) by NK cells. (uni-muenchen.de)
This Issues Arising paper is within response to Guo et al (2013) in mice we demonstrated which the neocortical ventricular zone (VZ) contains radial glial cells (RGCs) with restricted fate potentials (Franco et al. (exposed-skin-care.net)
E4 showed a binding pattern restricted to skin, macrophages and dendritic cells in lymphoid tissue, and cartilage derived from mouse and human arthritic joints. (bvsalud.org)

Because the brains of human epileptics are generally inaccessible for neurochemical research, the epileptic mouse mutants offer a convenient means of pursuing this type of research. (elsevierpure.com)

Female 6T mice have lower BMD and lower serum IGF-1 levels at all ages measured. (jax.org)
As the liver is the major source of serum IGF-1, we examined differential expression in the livers of fasted female B6 and 6T mice by microarray. (jax.org)
hIL-2 NOG mice produce human IL-2 in the range of 0.5-2.0 ng/mL as measured by MFI serology testing on DBS and serum in February 2023. (taconic.com)
ELISA tests are enzyme linked immunoassays to detect human, mouse or other proteins in serum, plasma, urine or biological fluids. (gentaur.com)

These results indicate that the volatiles in scent-marks provide information about genetic similarity of the mice, and support the idea that the production of these genetically determined volatiles is influenced by commensal microflora. (northumbria.ac.uk)

Naka T, Matsumoto T, Narazaki M, Fujimoto M, Morita Y, Ohsawa Y, Saito H, Nagasawa T, Uchiyama Y, and Kishimoto T. (1998) Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. (go.jp)

The well-known genetic constitution of the mouse, together with the availability of numerous physiologically distinct convulsive disorders, makes the mouse ideally suited for molecular, genetic, and biochemical studies of convulsive behavior. (elsevierpure.com)

Our futurestudies will straight test regardless of whether fucoidan can activate SR-A and whether activation of SR-A signaling in DCs can promote CLR responses in vivo by utilizing SR-A-knock out mouse. (bcrablinhibitor.com)

Fig. 1: Colonization of the skin with MmuPV1 protects mice against chemically induced skin carcinogenesis. (nature.com)

Vivek Kumar is using machine learning and computational science to examine frailty in mice to study the biology of aging. (jax.org)
But a substantial quantity of biology research has been built on traditionally constructed transgenic mice, and many labs continue to use them. (the-scientist.com)
An Integrated Systems Biology Approach to Identify Opioid-Induced Shifts in Function of the Gut Microbiome among Lean and Obese Mice Undergoing Systemic Opioid Treatment. (utk.edu)

Similar differences between WT and KO mice were seen whether LTP was induced in the presence or absence of a GABA A receptor blocker. (jneurosci.org)
No differences in hippocampal LTP were observed in WT and KO mice at any ages. (jneurosci.org)

The global market for mice models is expected to be evaluated at US$1.79 bn by the end of 2023. (prnewswire.com)
North America has consistently been a key region in terms of demand for mice models. (prnewswire.com)
Meanwhile, the demand for mice models is expected to expand at a CAGR of 11.1% in Asia Pacific , from 2015 to 2023. (prnewswire.com)
By 2023, North America will generated a revenue of US$785.4 mn in mice models. (prnewswire.com)
Research on diabetic complications has been hampered by the limitation that most of the animal models used for T1D (NOD mice, BB rat) or T2D (db/db mice, GK rat) do not develop classical micro- and macrovascular complications. (lu.se)

None of the ACPAs showed arthritogenicity nor induced pain-associated behavior in mice. (bvsalud.org)

These new findings will extend the utility of the hph-1 mouse in studies of GTP-CH I deficiency. (ox.ac.uk)

Anatomy1

Organisms6

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. (1/709)

The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. (2/709)

Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. (3/709)

Evidence of alternative or concomitant use of perforin- and Fas-dependent pathways in a T cell-mediated negative regulation of Ig production. (4/709)

Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus. (5/709)

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment. (6/709)

A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. (7/709)

No images available that match "mice congenic"

Mice, Congenic

Animals, Congenic

Mice, Inbred C57BL

Mice, Inbred NOD

Chromosomes, Mammalian

Crosses, Genetic

Quantitative Trait Loci

Chromosome Mapping

Mice, Inbred Strains

Rats, Inbred Dahl

Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. (1/709)

The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. (2/709)

Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. (3/709)

Evidence of alternative or concomitant use of perforin- and Fas-dependent pathways in a T cell-mediated negative regulation of Ig production. (4/709)

Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus. (5/709)

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment. (6/709)

A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. (7/709)

c-kitUsing Ly5 congenic mice, we characterized the early differentiation step of pluripotent hemopoietic stem cells. Lineage- (Lin-)/CD71- cells in the bone marrow cells were separated into major histocompatibility complex (MHC) class I(high)/c-kit(low) and MHC class I(high)/c-kit+info)12345678910

Congenic

Bone morphogenetic protein 6

Wallace P. Rowe

Borrelia lusitaniae

Borrelia japonica

Behavioral neuroscience

Mate choice

Mate choice in humans

Taconic Biosciences

Bone marrow adipose tissue

PTPRC

Inbreeding

Hebb-Williams maze

Inbred strain

NOD mice

List of MeSH codes (B01)

Jan Klein

Passive immunity

Rat Genome Database

Santa Ono

Zinc transporter ZIP12

Influenza A virus subtype H7N9

Mapping of asthma susceptibility in recombinant congenic mouse strains | News articles | University of Groningen

Mouse Speed Congenic Services

SOCS1 KO (BALB/c congenic) mice | JCRB Laboratory Animal Resource Bank at NIBIOHN

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse. - Oxford Cardiovascular Science

Mice Model Market is Projected to Reach US$1.79 bn by the end of 2023; Mice Model Usage Increases in Scope through Advanced...

"Alteration of ig expression in congenic mouse strains. Abstr." by M Bosma and G Bosma

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary...

Rom OT-II mice have been labeled with CFSE and transferred into CD45.1 congenic mice, and | Crab Inhibitor.com

Liver expression of B6.C3H-6T (6T) (congenic mice with low serum IGF-1) and C57BL/6J mice | Churchill Lab

Genetic Analysis of Skull Shape Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic...

Consensus multivariate methods in gas chromatography mass spectrometry and denaturing gradient gel electrophoresis: MHC...

Faculty Collaboration Database - Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. ...

Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic...

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm Strain Detail MGI Mouse MGI:6197222

Congenic - Wikipedia

HIV-Associated Nephropathy and Other HIV-Related Renal Disorders: Practice Essentials, Pathophysiology, Epidemiology

Age-Dependent and Selective Impairment of Long-Term Potentiation in the Anterior Piriform Cortex of Mice Lacking the Fragile X...

Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression |...

Vaccines | Free Full-Text | Dendritic Cell Tumor Vaccination via Fc Gamma Receptor Targeting: Lessons Learned from Pre-Clinical...

NIOSHTIC-2 Search Results - Full View

"The Animal" After Derrida: Interrogating the Bio… - Les ateliers de l'éthique / The Ethics Forum -...

Cellular senescence: an unexpected advantage in wound healing

Immunogenicity Threshold in Allogeneic Cells Impacts CTL Response to Nondominant Congenic Antigens | The Journal of Immunology ...

Cortical Neural Activity Predicts Sensory Acuity Under Optogenetic Manipulation | Journal of Neuroscience

Immunity to commensal papillomaviruses protects against skin cancer | Nature

Molecular Vision: Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens

Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor | Clinical Cancer Research |...

Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway | eLife

Strains26

C57BL21

Mutation8

Chromosome3

Locus9

Knockout9

Genes3

CD45.12

Gene7

Rats2

Susceptibility3