'Methylamines' are organic compounds consisting of a methyl group (CH3) linked to an amino group (-NH2), with the general formula of CH3-NH-R, where R can be a hydrogen atom or any organic group, and they exist as colorless gases or liquids at room temperature.
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.
A species of bacteria isolated from soil.
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Dimethylamines are organic compounds that contain two methyl groups (-CH3) bonded to a nitrogen atom (N), with the general formula (CH3)2NH. They can act as secondary amines and are commonly used in chemical synthesis, but they are not typically found as natural components in the human body.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Semicarbazides are organic compounds containing a functional group with the structure NH2-NH-CO-NH2, which are commonly used as reagents in chemical reactions to form semicarbazones, and can also be found in some pharmaceuticals and industrial chemicals.
A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
Butylamines are a class of organic compounds where a butyl group is attached to an amine functional group, with the general structure (C4H9)NHR or (C4H9)NR'R", commonly used as stimulants, entactogens, and psychedelics.
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.
A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.
An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.
A delayed rectifier subtype of shaker potassium channels that has been described in NEURONS and ASTROCYTES.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
The rate dynamics in chemical or physical systems.
Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
A genus of gram-negative, rod-shaped bacteria that derives energy from the oxidation of one or more reduced sulfur compounds. Many former species have been reclassified to other classes of PROTEOBACTERIA.
A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
A foul-smelling diamine formed by bacterial decarboxylation of lysine.
A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. The protein has a molecular weight of approximately 16,000, contains a single copper atom, is intensively blue, and has a fluorescence emission band centered at 308nm.
A family of gram-negative, aerobic bacteria utilizing only one-carbon organic compounds and isolated from in soil and water.
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
An aspect of monoamine oxidase, EC 1.4.3.4. Catalyzes the oxidation of benzylamine to form benzaldehyde, ammonia and hydrogen peroxide.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
A subclass of cartilaginous fish comprising the SHARKS; rays; skates (SKATES (FISH);), and sawfish. Elasmobranchs are typically predaceous, relying more on smell (the olfactory capsules are relatively large) than sight (the eyes are relatively small) for obtaining their food.
Gram-negative non-motile bacteria found in soil or brines.
A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.
Used as an electron carrier in place of the flavine enzyme of Warburg in the hexosemonophosphate system and also in the preparation of SUCCINIC DEHYDROGENASE.
'Ethylamines' are organic compounds containing an ethyl group (two carbon atoms) bonded to an amino group (-NH2), which can vary in their complexity and properties, playing a role in various biological processes or utilized in the synthesis of numerous pharmaceuticals and chemicals.
Phenazines are nitrogen-containing heterocyclic compounds that have been widely studied for their antibacterial, antifungal, and antiparasitic properties, and can be found in various natural sources such as bacteria and fungi, or synthesized chemically.
An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
An anticonvulsant that is the active metabolite of TRIMETHADIONE.
The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
The type species of gram negative bacteria in the genus ALCALIGENES, found in soil. It is non-pathogenic, non-pigmented, and used for the production of amino acids.
Serum globulins with high molecular weight. (Dorland, 28th ed)
A family of gram-negative bacteria in the order Methylophilales.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Cyclic TETRAPYRROLES based on the corrin skeleton.
3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Proteins that have one or more tightly bound metal ions forming part of their structure. (Dorland, 28th ed)
A genus of anaerobic, irregular spheroid-shaped METHANOSARCINALES whose organisms are nonmotile. Endospores are not formed. These archaea derive energy via formation of methane from acetate, methanol, mono-, di-, and trimethylamine, and possibly, carbon monoxide. Organisms are isolated from freshwater and marine environments.

Haloanaerobacter salinarius sp. nov., a novel halophilic fermentative bacterium that reduces glycine-betaine to trimethylamine with hydrogen or serine as electron donors; emendation of the genus Haloanaerobacter. (1/852)

A novel halophilic fermentative bacterium has been isolated from the black sediment below a gypsum crust and a microbial mat in hypersaline ponds of Mediterranean salterns. Morphologically, physiologically and genetically this organism belongs to the genus Haloanaerobacter. Haloanaerobacter strain SG 3903T (T = type strain) is composed of non-sporulating long flexible rods with peritrichous flagella, able to grow in the salinity range of 5-30% NaCl, with an optimum at 14-15%. The strain grows by fermenting carbohydrates or by using the Stickland reaction with either serine or H2 as electron donors and glycine-betaine as acceptor, which is reduced to trimethylamine. The two species described so far in the genus Haloanaerobacter are not capable of Stickland reaction with glycine-betaine + serine; however, Haloanaerobacter chitinovorans can use glycine-betaine with H2 as electron donor. Strain SG 3903T thus represents the first described strain in the genus Haloanaerobacter capable of the Stickland reaction with two amino acids. Although strain SG 3903T showed 67% DNA-DNA relatedness to H. chitinovorans, it is physiologically sufficiently different from the two described species to be considered as a new species which has been named Haloanaerobacter salinarius sp. nov.  (+info)

Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition. (2/852)

1. Hypoxia (PO2 < 5 mmHg) decreased vessel tone in isolated rat mesenteric arteries precontracted with either high [K+] or the thromboxane analogue U46619. This response was not altered by N-nitro-L-arginine (L-NA) and indomethacin. 2. Simultaneous measurement of pHi and tension showed that the decrease in vessel tone was accompanied by an intracellular acidification. Similar reductions in tone and pHi were observed with the metabolic inhibitors 2,4-dinitrophenol (DNP) and sodium azide. 3. The presence of the lactate transport inhibitor alpha-cyano-4-hydroxy-cinnamic acid (CHC) increased the magnitude of the acidification and resulted in a significantly faster reduction in tone in response to hypoxia. Addition of CHC to normoxic tissues caused both a vasodilatation and a reduction of pHi. 4. A decrease in pHi induced on washout of ammonium chloride (NH4Cl) resulted in an increase in tone. 5. Relaxation to hypoxia or metabolic inhibition was unaffected when the change in pHi was neutralized by addition of the weak base trimethylamine (TMA). 6. It is concluded that severe hypoxia decreases tone in isolated rat mesenteric arteries by a mechanism which is independent of nitric oxide and prostaglandins. Both severe hypoxia and metabolic inhibition reduced pHi, although this does not appear to be contributing to the changes in tone observed.  (+info)

Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor. (3/852)

A number of biologically important proteins or protein domains identified recently are fully or partially unstructured (unfolded). Methods that allow studies of the propensity of such proteins to fold naturally are valuable. The traditional biophysical approaches using alcohols to drive alpha-helix formation raise serious questions of the relevance of alcohol-induced structure to the biologically important conformations. Recently we illustrated the extraordinary capability of the naturally occurring solute, trimethylamine N-oxide (TMAO), to force two unfolded proteins to fold to native-like species with significant functional activity. In the present work we apply this technique to recombinant human glucocorticoid receptor fragments consisting of residues 1-500 and residues 77-262. CD and fluorescence spectroscopy showed that both were largely disordered in aqueous solution. TMAO induced a condensed structure in the large fragment, indicated by the substantial enhancement in intrinsic fluorescence and blue shift of fluorescent maxima. CD spectroscopy demonstrated that the TMAO-induced structure is different from the alpha-helix-rich conformation driven by trifluoroethanol (TFE). In contrast to TFE, the conformational transition of the 1-500 fragment induced by TMAO is cooperative, a condition characteristic of proteins with unique structures.  (+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (4/852)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. (5/852)

The regulation of intracellular ion concentrations is a fundamental property of living cells. Although many ion transporters have been identified, the systems that modulate their activity remain largely unknown. We have characterized two partially redundant genes from Saccharomyces cerevisiae, HAL4/SAT4 and HAL5, that encode homologous protein kinases implicated in the regulation of cation uptake. Overexpression of these genes increases the tolerance of yeast cells to sodium and lithium, whereas gene disruptions result in greater cation sensitivity. These phenotypic effects of the mutations correlate with changes in cation uptake and are dependent on a functional Trk1-Trk2 potassium transport system. In addition, hal4 hal5 and trk1 trk2 mutants exhibit similar phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium, tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential. These results suggest that the Hal4 and Hal5 protein kinases activate the Trk1-Trk2 potassium transporter, increasing the influx of potassium and decreasing the membrane potential. The resulting loss in electrical driving force reduces the uptake of toxic cations and improves salt tolerance. Our data support a role for regulation of membrane potential in adaptation to salt stress that is mediated by the Hal4 and Hal5 kinases.  (+info)

The reaction of trimethylamine dehydrogenase with trimethylamine. (6/852)

The reductive half-reaction of trimethylamine dehydrogenase with its physiological substrate trimethylamine has been examined by stopped-flow spectroscopy over the pH range 6.0-11.0, with attention focusing on the fastest of the three kinetic phases of the reaction, the flavin reduction/substrate oxidation process. As in previous work with the slow substrate diethylmethylamine, the reaction is found to consist of three well resolved kinetic phases. The observed rate constant for the fast phase exhibits hyperbolic dependence on the substrate concentration with an extrapolated limiting rate constant (klim) greater than 1000 s-1 at pH above 8.5, 10 degrees C. The kinetic parameter klim/Kd for the fast phase exhibits a bell-shaped pH dependence, with two pKa values of 9.3 +/- 0.1 and 10. 0 +/- 0.1 attributed to a basic residue in the enzyme active site and the ionization of the free substrate, respectively. The sigmoidal pH profile for klim gives a single pKa value of 7.1 +/- 0. 2. The observed rate constants for both the intermediate and slow phases are found to decrease as the substrate concentration is increased. The steady-state kinetic behavior of trimethylamine dehydrogenase with trimethylamine has also been examined, and is found to be adequately described without invoking a second, inhibitory substrate-binding site. The present results demonstrate that: (a) substrate must be protonated in order to bind to the enzyme; (b) an ionization group on the enzyme is involved in substrate binding; (c) an active site general base is involved, but not strictly required, in the oxidation of substrate; (d) the fast phase of the reaction with native enzyme is considerably faster than observed with enzyme isolated from Methylophilus methylotrophus that has been grown up on dimethylamine; and (e) a discrete inhibitory substrate-binding site is not required to account for excess substrate inhibition, the kinetic behavior of trimethylamine dehydrogenase can be readily explained in the context of the known properties of the enzyme.  (+info)

The role of Tyr-169 of trimethylamine dehydrogenase in substrate oxidation and magnetic interaction between FMN cofactor and the 4Fe/4S center. (7/852)

Tyr-169 in trimethylamine dehydrogenase is one component of a triad also comprising residues His-172 and Asp-267. Its role in catalysis and in mediating the magnetic interaction between FMN cofactor and the 4Fe/4S center have been investigated by stopped-flow and EPR spectroscopy of a Tyr-169 to Phe (Y169F) mutant of the enzyme. Tyr-169 is shown to play an important role in catalysis (mutation to phenylalanine reduces the limiting rate constant for bleaching of the active site flavin by about 100-fold) but does not serve as a general base in the course of catalysis. In addition, we are able to resolve two kinetically influential ionizations involved in both the reaction of free enzyme with free substrate (as reflected in klim/Kd), and in the breakdown of the Eox.S complex (as reflected in klim). In EPR studies of the Y169F mutant, it is found that the ability of the Y169F enzyme to form the spin-interacting state between flavin semiquinone and reduced 4Fe/4S center characteristic of wild-type enzyme is significantly compromised. The present results are consistent with Tyr-169 representing the ionizable group of pKa approximately 9.5, previously identified in pH-jump studies of electron transfer, whose deprotonation must occur for the spin-interacting state to be established.  (+info)

Common components of patch-clamp internal recording solutions can significantly affect protein kinase A activity. (8/852)

Common components of whole-cell internal recording solutions were tested both in vitro and in patch-clamp experiments for their effects on the activity of cAMP-dependent protein kinase. Potassium fluoride (KF), 440 mM trimethylamine chloride and exclusion of bovine serum albumin (BSA) decreased the activity of the enzyme, while ethylene glycol-bis (beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA) and the potassium salts of aspartate, gluconate, methylsulfate and monobasic phosphate increased its activity. Addition of KF to the internal solution produced a hyperpolarizing shift in the V1/2 of Ih channel activation, consistent with the KF-induced reduction of protein kinase A activity. Therefore, consideration of the composition of internal solutions is warranted when studying channel physiology by patch-clamp techniques.  (+info)

Methylamines are organic compounds that contain a methyl group (CH3) and an amino group (-NH2). They have the general formula of CH3-NH-R, where R can be a hydrogen atom or any organic group. Methylamines are derivatives of ammonia (NH3), in which one or more hydrogen atoms have been replaced by methyl groups.

There are several types of methylamines, including:

1. Methylamine (CH3-NH2): This is the simplest methylamine and is a colorless gas at room temperature with a strong odor. It is highly flammable and reactive.
2. Dimethylamine (CH3)2-NH: This is a colorless liquid at room temperature with an unpleasant fishy odor. It is less reactive than methylamine but still highly flammable.
3. Trimethylamine (CH3)3-N: This is a colorless liquid at room temperature that has a strong, unpleasant odor often described as "fishy." It is less reactive than dimethylamine and is used in various industrial applications.

Methylamines are used in the production of various chemicals, including pesticides, dyes, and pharmaceuticals. They can also be found naturally in some foods and are produced by certain types of bacteria in the body. Exposure to high levels of methylamines can cause irritation to the eyes, skin, and respiratory tract, and prolonged exposure can lead to more serious health effects.

Oxidoreductases acting on CH-NH group donors are a class of enzymes within the larger group of oxidoreductases, which are responsible for catalyzing oxidation-reduction reactions. Specifically, this subclass of enzymes acts on CH-NH group donors, where the CH-NH group is a chemical functional group consisting of a carbon atom (C) bonded to a nitrogen atom (N) via a single covalent bond.

These enzymes play a crucial role in various biological processes by transferring electrons from the CH-NH group donor to an acceptor molecule, which results in the oxidation of the donor and reduction of the acceptor. This process can lead to the formation or breakdown of chemical bonds, and plays a key role in metabolic pathways such as amino acid degradation and nitrogen fixation.

Examples of enzymes that fall within this class include:

* Amino oxidases, which catalyze the oxidative deamination of amino acids to produce alpha-keto acids, ammonia, and hydrogen peroxide.
* Transaminases, which transfer an amino group from one molecule to another, often in the process of amino acid biosynthesis or degradation.
* Amine oxidoreductases, which catalyze the oxidation of primary amines to aldehydes and secondary amines to ketones, with the concomitant reduction of molecular oxygen to hydrogen peroxide.

Indolequinones are a type of chemical compound that consist of an indole ring, which is a heterocyclic aromatic organic compound, fused to a quinone ring. They can be found in some natural sources, including certain types of bacteria and fungi, as well as in synthetic forms.

Indolequinones have been studied for their potential use in medical treatments, particularly in the area of cancer research. Some indolequinones have been shown to have antitumor properties and are being investigated as possible chemotherapeutic agents. However, they can also be toxic and may have side effects, so further research is needed to determine their safety and effectiveness for medical use.

"Paracoccus denitrificans" is not a medical term, but rather a term used in the field of microbiology. It refers to a species of gram-negative, facultatively anaerobic bacteria that are commonly found in soil and water environments. These bacteria are known for their ability to carry out denitrification, which is the process of converting nitrate (NO3-) to nitrogen gas (N2) under anaerobic conditions. This ability makes them important players in the global nitrogen cycle.

While "Paracoccus denitrificans" itself is not a medical term, certain strains of this bacterium have been used in medical research and biotechnology applications. For example, some researchers have studied the use of "Paracoccus denitrificans" as a potential agent for removing nitrogenous compounds from wastewater or for producing hydrogen gas through fermentation. However, there is no direct medical relevance to this bacterium in terms of human health or disease.

Alpha-macroglobulins are a type of large protein molecule found in blood plasma, which play a crucial role in the human body's immune system. They are called "macro" globulins because of their large size, and "alpha" refers to their electrophoretic mobility, which is a laboratory technique used to separate proteins based on their electrical charge.

Alpha-macroglobulins function as protease inhibitors, which means they help regulate the activity of enzymes called proteases that can break down other proteins in the body. By inhibiting these proteases, alpha-macroglobulins help protect tissues and organs from excessive protein degradation and also help maintain the balance of various biological processes.

One of the most well-known alpha-macroglobulins is alpha-1-antitrypsin, which helps protect the lungs from damage caused by inflammation and protease activity. Deficiencies in this protein have been linked to lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD).

Overall, alpha-macroglobulins are an essential component of the human immune system and play a critical role in maintaining homeostasis and preventing excessive tissue damage.

Dimethylamine is an organic compound with the formula (CH3)2NH. It is a colorless gas that is highly soluble in water and polar solvents. Dimethylamine is a derivative of ammonia (NH3) in which two hydrogen atoms are replaced by methyl groups (CH3).

Dimethylamines, in medical terminology, typically refer to compounds that contain the functional group -N(CH3)2. These compounds can have various biological activities and may be used as drugs or therapeutic agents. For example, dimethylamine is a metabolite of choline, a nutrient important for brain function.

However, it's worth noting that "dimethylamines" is not typically used as a medical term to describe a specific condition or diagnosis. If you have any concerns about exposure to dimethylamine or its potential health effects, it would be best to consult with a healthcare professional.

Amines are organic compounds that contain a basic nitrogen atom with a lone pair of electrons. They are derived from ammonia (NH3) by replacing one or more hydrogen atoms with alkyl or aryl groups. The nomenclature of amines follows the substitutive type, where the parent compound is named as an aliphatic or aromatic hydrocarbon, and the functional group "amine" is designated as a suffix or prefix.

Amines are classified into three types based on the number of carbon atoms attached to the nitrogen atom:

1. Primary (1°) amines: One alkyl or aryl group is attached to the nitrogen atom.
2. Secondary (2°) amines: Two alkyl or aryl groups are attached to the nitrogen atom.
3. Tertiary (3°) amines: Three alkyl or aryl groups are attached to the nitrogen atom.

Quaternary ammonium salts have four organic groups attached to the nitrogen atom and a positive charge, with anions balancing the charge.

Amines have a wide range of applications in the chemical industry, including pharmaceuticals, dyes, polymers, and solvents. They also play a significant role in biological systems as neurotransmitters, hormones, and cell membrane components.

Semicarbazides are organic compounds that contain the functional group -NH-CO-NH-NH2. They are derivatives of hydrazine and carbamic acid, with the general structure (CH3)NHCSNH2. Semicarbazides are widely used in the synthesis of various chemical compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals.

In a medical context, semicarbazides themselves do not have any therapeutic use. However, they can be used in the preparation of certain drugs or drug intermediates. For example, semicarbazones, which are derivatives of semicarbazides, can be used to synthesize some antituberculosis drugs.

It is worth noting that semicarbazides and their derivatives have been found to have mutagenic and carcinogenic properties in some studies. Therefore, they should be handled with care in laboratory settings, and exposure should be minimized to reduce potential health risks.

Methanol, also known as methyl alcohol or wood alcohol, is a volatile, colorless, flammable liquid with a distinctive odor similar to that of ethanol (drinking alcohol). It is used in various industrial applications such as the production of formaldehyde, acetic acid, and other chemicals. In the medical field, methanol is considered a toxic alcohol that can cause severe intoxication and metabolic disturbances when ingested or improperly consumed. Methanol poisoning can lead to neurological symptoms, blindness, and even death if not treated promptly and effectively.

Butylamines are a class of organic compounds that contain a butyl group (a chain of four carbon atoms) attached to an amine functional group, which consists of nitrogen atom bonded to one or more hydrogen atoms. The general structure of a primary butylamine is R-NH2, where R represents the butyl group.

Butylamines can be found in various natural and synthetic substances. Some of them have important uses in industry as solvents, intermediates in chemical synthesis, or building blocks for pharmaceuticals. However, some butylamines are also known to have psychoactive effects and may be used as recreational drugs or abused.

It is worth noting that the term "butylamine" can refer to any of several specific compounds, depending on the context. For example, n-butylamine (also called butan-1-amine) has the formula CH3CH2CH2CH2NH2, while tert-butylamine (also called 2-methylpropan-2-amine) has the formula (CH3)3CNH2. These two compounds have different physical and chemical properties due to their structural differences.

In a medical context, butylamines may be encountered as drugs of abuse or as components of pharmaceuticals. Some examples of butylamine-derived drugs include certain antidepressants, anesthetics, and muscle relaxants. However, it is important to note that these compounds are often highly modified from their parent butylamine structure, and may not resemble them closely in terms of their pharmacological properties or toxicity profiles.

'Methanosarcina barkeri' is not a medical term, but a species name in the domain of microbiology. It refers to a type of archaea (single-celled organisms) that is capable of methanogenesis - producing methane as a metabolic byproduct. This microorganism is commonly found in anaerobic environments such as wetlands, digestive tracts of animals, and sewage sludge. It's not something that typically has a direct medical definition or relevance, unless in the context of specific research or environmental/industrial settings.

Gram-negative aerobic bacteria are a type of bacteria that do not retain the crystal violet stain used in the Gram staining method, which is a technique used to differentiate bacterial species based on their cell wall composition. These bacteria have a thin peptidoglycan layer and an outer membrane containing lipopolysaccharides (LPS), making them resistant to many antibiotics and disinfectants. They are called aerobic because they require oxygen for their growth and metabolism. Examples of Gram-negative aerobic bacteria include Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. These bacteria can cause various infections in humans, such as pneumonia, urinary tract infections, and sepsis.

Ammonium chloride is an inorganic compound with the formula NH4Cl. It is a white crystalline salt that is highly soluble in water and can be produced by combining ammonia (NH3) with hydrochloric acid (HCl). Ammonium chloride is commonly used as a source of hydrogen ions in chemical reactions, and it has a variety of industrial and medical applications.

In the medical field, ammonium chloride is sometimes used as a expectorant to help thin and loosen mucus in the respiratory tract, making it easier to cough up and clear from the lungs. It may also be used to treat conditions such as metabolic alkalosis, a condition characterized by an excess of base in the body that can lead to symptoms such as confusion, muscle twitching, and irregular heartbeat.

However, it is important to note that ammonium chloride can have side effects, including stomach upset, nausea, vomiting, and diarrhea. It should be used under the guidance of a healthcare professional and should not be taken in large amounts or for extended periods of time without medical supervision.

The Kv1.6 potassium channel is a type of voltage-gated potassium channel that is encoded by the KCNA6 gene in humans. These channels are composed of four α subunits, each containing six transmembrane domains and a pore-forming region. The Kv1.6 channel specifically is known to be widely expressed in various tissues, including the brain, heart, and kidneys.

Kv1.6 channels play important roles in regulating electrical excitability and neurotransmitter release in neurons, as well as modulating action potential duration and repolarization in cardiac myocytes. They are also involved in the regulation of potassium secretion in the kidney's distal convoluted tubule.

Mutations in the KCNA6 gene have been associated with various human diseases, including epilepsy, spinocerebellar ataxia, and cardiac arrhythmias. Additionally, changes in Kv1.6 channel expression and function have been implicated in several pathological conditions, such as ischemia, inflammation, and cancer.

Ammonia is a colorless, pungent-smelling gas with the chemical formula NH3. It is a compound of nitrogen and hydrogen and is a basic compound, meaning it has a pH greater than 7. Ammonia is naturally found in the environment and is produced by the breakdown of organic matter, such as animal waste and decomposing plants. In the medical field, ammonia is most commonly discussed in relation to its role in human metabolism and its potential toxicity.

In the body, ammonia is produced as a byproduct of protein metabolism and is typically converted to urea in the liver and excreted in the urine. However, if the liver is not functioning properly or if there is an excess of protein in the diet, ammonia can accumulate in the blood and cause a condition called hyperammonemia. Hyperammonemia can lead to serious neurological symptoms, such as confusion, seizures, and coma, and is treated by lowering the level of ammonia in the blood through medications, dietary changes, and dialysis.

Hydrogen-ion concentration, also known as pH, is a measure of the acidity or basicity of a solution. It is defined as the negative logarithm (to the base 10) of the hydrogen ion activity in a solution. The standard unit of measurement is the pH unit. A pH of 7 is neutral, less than 7 is acidic, and greater than 7 is basic.

In medical terms, hydrogen-ion concentration is important for maintaining homeostasis within the body. For example, in the stomach, a high hydrogen-ion concentration (low pH) is necessary for the digestion of food. However, in other parts of the body such as blood, a high hydrogen-ion concentration can be harmful and lead to acidosis. Conversely, a low hydrogen-ion concentration (high pH) in the blood can lead to alkalosis. Both acidosis and alkalosis can have serious consequences on various organ systems if not corrected.

"Pseudomonas" is a genus of Gram-negative, rod-shaped bacteria that are widely found in soil, water, and plants. Some species of Pseudomonas can cause disease in animals and humans, with P. aeruginosa being the most clinically relevant as it's an opportunistic pathogen capable of causing various types of infections, particularly in individuals with weakened immune systems.

P. aeruginosa is known for its remarkable ability to resist many antibiotics and disinfectants, making infections caused by this bacterium difficult to treat. It can cause a range of healthcare-associated infections, such as pneumonia, bloodstream infections, urinary tract infections, and surgical site infections. In addition, it can also cause external ear infections and eye infections.

Prompt identification and appropriate antimicrobial therapy are crucial for managing Pseudomonas infections, although the increasing antibiotic resistance poses a significant challenge in treatment.

In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."

1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.

2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.

3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.

4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).

Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.

Allylamine is an organic compound with the formula CH2=CH-CH2-NH2. It is a colorless liquid that is soluble in water and polar organic solvents. Allylamine is used as a building block in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and polymers.

In the medical field, allylamine derivatives are used as antifungal agents. These drugs work by inhibiting the enzyme squalene epoxidase, which is necessary for the synthesis of ergosterol, a key component of fungal cell membranes. By blocking the production of ergosterol, allylamine derivatives disrupt the integrity of fungal cell membranes and prevent the growth of fungi. Examples of allylamine antifungal drugs include terbinafine and naftifine.

Thiobacillus is a genus of gram-negative, rod-shaped bacteria that are capable of oxidizing inorganic sulfur compounds and sulfides to produce sulfuric acid. These bacteria play a significant role in the biogeochemical cycles of sulfur and carbon, particularly in environments like soil, water, and sediments. They are widely distributed in nature and can be found in various habitats such as acid mine drainage, sewage treatment plants, and even in the human respiratory system. Some species of Thiobacillus have been used in industrial applications for the bioremediation of heavy metal-contaminated soils and wastewater treatment. However, they can also contribute to the corrosion of metals and concrete structures due to their acid production.

Arthrobacter is a genus of Gram-positive, catalase-positive, aerobic bacteria that are commonly found in soil and water. These bacteria are known for their ability to degrade various organic compounds, including hydrocarbons, and are often used in bioremediation applications. The cells of Arthrobacter species are typically rod-shaped and may appear slightly curved or irregular. They can form dormant structures called exospores that allow them to survive in harsh environments. Arthrobacter species are not considered human pathogens and do not cause disease in humans.

Cadaverine is a foul-smelling organic compound that is produced by the breakdown of certain amino acids in dead bodies. It is formed through the decarboxylation of lysine, an essential amino acid, and is characterized by its strong, unpleasant odor. Cadaverine is often used as a forensic indicator of decomposition and is also being studied for its potential role in various physiological processes, such as inflammation and cancer.

Azurin is a small protein with a blue copper center, which is involved in electron transfer reactions. It is produced by the bacterium *Pseudomonas aeruginosa*, and has been studied for its potential role in wound healing and as an anticancer agent. The name "azurin" comes from the fact that this protein has a bright blue color due to its copper ion content.

Methylococcaceae is a family of bacteria that have the ability to oxidize methane as their source of carbon and energy. These bacteria are also known as methanotrophs. They are gram-negative, aerobic, and typically occur in freshwater and marine environments. The family includes several genera such as Methylococcus, Methylomonas, and Methylothermus. These bacteria play an important role in the global carbon cycle by converting methane, a potent greenhouse gas, into carbon dioxide.

Formaldehyde is a colorless, pungent, and volatile chemical compound with the formula CH2O. It is a naturally occurring substance that is found in certain fruits like apples and vegetables, as well as in animals. However, the majority of formaldehyde used in industry is synthetically produced.

In the medical field, formaldehyde is commonly used as a preservative for biological specimens such as organs, tissues, and cells. It works by killing bacteria and inhibiting the decaying process. Formaldehyde is also used in the production of various industrial products, including adhesives, resins, textiles, and paper products.

However, formaldehyde can be harmful to human health if inhaled or ingested in large quantities. It can cause irritation to the eyes, nose, throat, and skin, and prolonged exposure has been linked to respiratory problems and cancer. Therefore, it is essential to handle formaldehyde with care and use appropriate safety measures when working with this chemical compound.

Benzylamine oxidase is an enzyme that catalyzes the oxidation of benzylamine and related compounds to their corresponding nitroso or nitro derivatives. It is found in various organisms, including bacteria, fungi, and plants. The enzyme plays a role in the detoxification of aromatic amines and contributes to the degradation of certain xenobiotics. Benzylamine oxidase requires flavin adenine dinucleotide (FAD) as a cofactor for its activity.

Mechlorethamine is an antineoplastic agent, which means it is used to treat cancer. It is a type of alkylating agent, which is a class of drugs that work by interfering with the DNA of cancer cells, preventing them from dividing and growing. Mechlorethamine is used in the treatment of Hodgkin's lymphoma and non-Hodgkin's lymphoma, as well as some other types of cancer. It can be administered intravenously or topically (as a cream) to treat skin lesions caused by certain types of cancer.

Mechlorethamine is a potent drug that can have significant side effects, including nausea, vomiting, hair loss, and an increased risk of infection due to suppression of the immune system. It can also cause damage to the heart, lungs, and reproductive system with long-term use. As with all chemotherapy drugs, mechlorethamine should be administered under the close supervision of a healthcare professional.

'Elasmobranchii' is a superorder in the class Chondrichthyes, which includes all sharks, skates, rays, and sawfishes. This group is characterized by several distinct features, including:

1. Cartilaginous skeletons: Unlike bony fishes, elasmobranchs have skeletons made of cartilage rather than bone.
2. Five to seven gill slits: Most elasmobranchs have five pairs of gill slits on each side of their body, although some species may have six or seven pairs. These gill slits are open to the outside environment and lack protective covers found in bony fishes.
3. Heterocercal tail: Elasmobranchs possess a unique tail structure called a heterocercal tail, where the upper lobe is longer than the lower lobe. This tail design provides powerful propulsion and maneuverability in the water.
4. Dermal denticles: The skin of elasmobranchs is covered with small, tooth-like structures called dermal denticles, which provide a protective covering and reduce friction while swimming.
5. No swim bladders: Unlike bony fishes, elasmobranchs do not have a gas-filled swim bladder to help maintain buoyancy. Instead, they rely on their large liver, which contains low-density oil, to provide some degree of buoyancy.
6. Electrosensory organs: Many elasmobranchs possess specialized sensory organs called the ampullae of Lorenzini, which allow them to detect electric fields generated by living organisms and other environmental sources. This ability aids in hunting, navigation, and communication.
7. Carnivorous diet: Elasmobranchs are primarily carnivorous, feeding on various marine animals such as fish, squid, and crustaceans. Some species may also consume smaller elasmobranchs.
8. Live birth or egg laying: Most elasmobranchs reproduce by giving live birth (viviparity), where the embryos develop inside the mother's body and receive nourishment through a placenta-like structure. However, some species lay eggs (oviparity) in protective cases called mermaid's purses.
9. Slow growth and late maturity: Elasmobranchs generally grow slowly and reach sexual maturity at a relatively advanced age compared to many bony fishes. This slow life history makes them particularly vulnerable to overfishing and other human-induced threats.

"Paracoccus" is not a medical term itself, but it is a genus name in the family of bacteria called "Paracoccaceae." The bacteria belonging to this genus are typically found in various environments such as soil, water, and sewage. Some species of Paracoccus have been reported to cause infections in humans, particularly in individuals with weakened immune systems. However, such infections are rare.

In a medical context, if a patient has an infection caused by a bacterium identified as Paracoccus, it would typically be described using the specific species name (e.g., Paracoccus yeei) and information about the site of infection, symptoms, and treatment approach.

Benzoylarginine nitroanilide is a synthetic peptide derivative that is often used as a substrate in enzyme assays, particularly for testing the activity of proteases (enzymes that break down proteins). Proteases cleave the peptide bond between benzoyl and arginine in the molecule, releasing p-nitroaniline, which can be easily measured spectrophotometrically. This allows researchers to quantify the activity of protease enzymes in a sample. It is also known as Benzoyl-L-arginine ρ-nitroanilide hydrochloride or BAPNA.

Methylphenazonium methosulfate is not a medication itself, but rather a reagent used in the production and pharmacological research of certain medications. It's commonly used as a redox mediator, which means it helps to facilitate electron transfer in chemical reactions. In medical contexts, it may be used in the laboratory synthesis or testing of some drugs.

It's important to note that methylphenazonium methosulfate is not intended for direct medical use in humans or animals. Always consult with a healthcare professional or trusted medical source for information regarding specific medications and their uses.

Ethylamines are organic compounds that contain a primary amino group (-NH2) attached to an ethyl group (-C2H5). In other words, they have the formula R-CH2-CH2-NH2, where R is a carbon-containing group. Ethylamines are derivatives of ammonia (NH3), in which one or more hydrogen atoms have been replaced by an ethyl group.

Ethylamines can be found in various natural and synthetic substances. They are used as building blocks in the synthesis of various pharmaceuticals, agrochemicals, and other industrial chemicals. Some ethylamines also have psychoactive properties and are used as recreational drugs or abused for their mind-altering effects.

It is important to note that some ethylamines can be toxic or harmful to human health, especially at high concentrations or with prolonged exposure. Therefore, they should be handled with care and used only under controlled conditions.

Phenazines are a class of heterocyclic aromatic organic compounds that consist of two nitrogen atoms connected by a five-membered ring. They are naturally occurring in various species of bacteria and fungi, where they play a role in chemical defense and communication. Some phenazines have been found to have antibiotic, antifungal, and antiparasitic properties. Synthetic phenazines are also used in various industrial applications, such as dyes and pigments, and as components in some pharmaceuticals and agrochemicals.

Monensin is a type of antibiotic known as a polyether ionophore, which is used primarily in the veterinary field for the prevention and treatment of coccidiosis, a parasitic disease caused by protozoa in animals. It works by selectively increasing the permeability of cell membranes to sodium ions, leading to disruption of the ion balance within the cells of the parasite and ultimately causing its death.

In addition to its use as an animal antibiotic, monensin has also been studied for its potential effects on human health, including its ability to lower cholesterol levels and improve insulin sensitivity in type 2 diabetes. However, it is not currently approved for use in humans due to concerns about toxicity and potential side effects.

Phenylhydrazines are organic compounds that contain a phenyl group (a benzene ring with a hydrogen atom substituted by a hydroxy group) and a hydrazine group (-NH-NH2). They are aromatic amines that have been used in various chemical reactions, including the formation of azos and hydrazones. In medicine, phenylhydrazines were once used as vasodilators to treat angina pectoris, but their use has largely been discontinued due to their toxicity and potential carcinogenicity.

Quinones are a class of organic compounds that contain a fully conjugated diketone structure. This structure consists of two carbonyl groups (C=O) separated by a double bond (C=C). Quinones can be found in various biological systems and synthetic compounds. They play important roles in many biochemical processes, such as electron transport chains and redox reactions. Some quinones are also known for their antimicrobial and anticancer properties. However, some quinones can be toxic or mutagenic at high concentrations.

Trypsin inhibitors are substances that inhibit the activity of trypsin, an enzyme that helps digest proteins in the small intestine. Trypsin inhibitors can be found in various foods such as soybeans, corn, and raw egg whites. In the case of soybeans, trypsin inhibitors are denatured and inactivated during cooking and processing.

In a medical context, trypsin inhibitors may be used therapeutically to regulate excessive trypsin activity in certain conditions such as pancreatitis, where there is inflammation of the pancreas leading to the release of activated digestive enzymes, including trypsin, into the pancreas and surrounding tissues. By inhibiting trypsin activity, these inhibitors can help reduce tissue damage and inflammation.

Dimethadione is a central nervous system stimulant and an anticonvulsant drug. It is a derivative of methadone and is used in the treatment of seizure disorders, such as epilepsy. The drug works by decreasing abnormal electrical activity in the brain, which can help to prevent or reduce the frequency of seizures.

Dimethadione is no longer commonly used due to its potential for serious side effects, including kidney damage and blood disorders. It should only be used under the close supervision of a healthcare provider, and patients should be closely monitored for signs of toxicity while taking this medication.

It's important to note that dimethadione is not approved by the FDA for use in the United States, but it may still be available in other countries with different regulatory agencies. As always, it's essential to consult a healthcare professional before using any medication.

Chloroquine is an antimalarial and autoimmune disease drug. It works by increasing the pH or making the environment less acidic in the digestive vacuoles of malaria parasites, which inhibits the polymerization of heme and the formation of hemozoin. This results in the accumulation of toxic levels of heme that are harmful to the parasite. Chloroquine is also used as an anti-inflammatory agent in the treatment of rheumatoid arthritis, discoid or systemic lupus erythematosus, and photodermatitis.

The chemical name for chloroquine is 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline, and it has a molecular formula of C18H26ClN3. It is available in the form of phosphate or sulfate salts for oral administration as tablets or solution.

Chloroquine was first synthesized in 1934 by Bayer scientists, and it has been widely used since the 1940s as a safe and effective antimalarial drug. However, the emergence of chloroquine-resistant strains of malaria parasites has limited its use in some areas. Chloroquine is also being investigated for its potential therapeutic effects on various viral infections, including COVID-19.

*Alcaligenes faecalis* is a species of gram-negative, rod-shaped bacteria that is commonly found in the environment, including soil, water, and the gastrointestinal tracts of animals. It is a facultative anaerobe, which means it can grow in both aerobic (with oxygen) and anaerobic (without oxygen) conditions.

The bacteria are generally not harmful to healthy individuals, but they have been associated with various types of infections in people with weakened immune systems or underlying medical conditions. These infections can include urinary tract infections, wound infections, pneumonia, and bacteremia (bloodstream infections).

*Alcaligenes faecalis* is resistant to many antibiotics, which can make treating infections caused by this bacteria challenging. It is important to identify the specific species of bacteria causing an infection so that appropriate antibiotic therapy can be administered.

Macroglobulins are high molecular weight immunoglobulins, specifically, IgM antibodies. They are called "macro" because of their large size, which is approximately 10 times larger than other types of immunoglobulins (IgG, IgA, and IgD). Macroglobulins are normally present in low concentrations in the blood, but their levels can increase in certain medical conditions such as macroglobulinemia, lymphoma, multiple myeloma, and other chronic inflammatory diseases.

Elevated levels of macroglobulins can cause various symptoms, including fatigue, weakness, bleeding, and neurological problems due to the increased viscosity of the blood. Macroglobulins can also interfere with laboratory tests, leading to false positive results for certain conditions. Treatment for elevated macroglobulins depends on the underlying cause and may include chemotherapy, radiation therapy, or other targeted therapies.

Methylophilaceae is a family of bacteria within the order Burkholderiales. These bacteria are known to be capable of growth on reduced one-carbon compounds such as methanol and formate as their sole source of carbon and energy. They are often found in various environments including soil, water, and sewage sludge. Some species within this family are also known to be able to degrade certain aromatic compounds. It's important to note that medical definition of Methylophilaceae is not commonly used since they are not associated with any specific human disease, but rather studied for their metabolic capabilities and potential applications in bioremediation and bioenergy production.

Amino alcohols are organic compounds containing both amine and hydroxyl (alcohol) functional groups. They have the general structure R-NH-OH, where R represents a carbon-containing group. Amino alcohols can be primary, secondary, or tertiary, depending on the number of alkyl or aryl groups attached to the nitrogen atom.

These compounds are important in many chemical and biological processes. For example, some amino alcohols serve as intermediates in the synthesis of pharmaceuticals, dyes, and polymers. In biochemistry, certain amino alcohols function as neurotransmitters or components of lipids.

Some common examples of amino alcohols include:

* Ethanolamine (monoethanolamine, MEA): a primary amino alcohol used in the production of detergents, emulsifiers, and pharmaceuticals
* Serinol: a primary amino alcohol that occurs naturally in some foods and is used as a flavoring agent
* Choline: a quaternary ammonium compound with a hydroxyl group, essential for human nutrition and found in various foods such as eggs, liver, and peanuts
* Trimethylamine (TMA): a tertiary amino alcohol that occurs naturally in some marine animals and is responsible for the "fishy" odor of their flesh.

PQQ, or pyrroloquinoline quinone, is a redox cofactor that plays a role in the electron transfer chain and is involved in various redox reactions in the body. It can be found in some bacteria and plants, and there is evidence to suggest that it may also be present in human tissues. However, the exact role of PQQ as a cofactor in humans is not well understood and more research is needed to fully understand its functions and potential health benefits.

A cofactor is a non-protein chemical compound that is required for an enzyme to function. Cofactors can be inorganic ions, such as iron or magnesium, or organic molecules, like PQQ. They play a crucial role in catalyzing biochemical reactions and maintaining the structural integrity of proteins.

In summary, PQQ is a redox cofactor that may have a role in various redox reactions in the body, but its exact functions and significance in human health are still being studied.

Corrinoids are a class of compounds that include vitamin B12 and its analogs. Vitamin B12 is an essential nutrient for humans and other animals, playing a critical role in the synthesis of DNA, the maintenance of the nervous system, and the metabolism of fatty acids and amino acids.

The corrinoid ring is the structural backbone of vitamin B12 and its analogs. It is a complex, planar molecule made up of four pyrrole rings joined together in a macrocycle. The corrinoid ring contains a central cobalt ion, which can form coordination bonds with various ligands, including organic groups such as methyl, hydroxo, and cyano.

Corrinoids can be found in a wide variety of foods, including meat, dairy products, fish, eggs, and some fortified plant-based foods. They are also produced by certain bacteria, which can synthesize the corrinoid ring and the cobalt ion de novo. Some corrinoids have biological activity similar to vitamin B12, while others do not.

In addition to their role in human nutrition, corrinoids are also used in industrial applications, such as the production of antibiotics and other pharmaceuticals. They are also used as catalysts in chemical reactions, due to their ability to form stable coordination complexes with various ligands.

Theobromine is defined as a bitter, crystalline alkaloid of the cacao plant, and is found in chocolate, especially cocoa. It is a stimulant that primarily affects the heart and cardiovascular system, and to a lesser extent the central nervous system. Theobromine is also found in the kola nut and tea leaves.

In a medical context, theobromine may be used as a vasodilator and diuretic. It can help to relax muscles, widen blood vessels, and increase urine production. However, it is important to note that theobromine is toxic to some animals, including dogs and cats, and can cause serious medical problems or even death if ingested in large quantities.

Tryptophan is an essential amino acid, meaning it cannot be synthesized by the human body and must be obtained through dietary sources. Its chemical formula is C11H12N2O2. Tryptophan plays a crucial role in various biological processes as it serves as a precursor to several important molecules, including serotonin, melatonin, and niacin (vitamin B3). Serotonin is a neurotransmitter involved in mood regulation, appetite control, and sleep-wake cycles, while melatonin is a hormone that regulates sleep-wake patterns. Niacin is essential for energy production and DNA repair.

Foods rich in tryptophan include turkey, chicken, fish, eggs, cheese, milk, nuts, seeds, and whole grains. In some cases, tryptophan supplementation may be recommended to help manage conditions related to serotonin imbalances, such as depression or insomnia, but this should only be done under the guidance of a healthcare professional due to potential side effects and interactions with other medications.

Metalloproteins are proteins that contain one or more metal ions as a cofactor, which is required for their biological activity. These metal ions play crucial roles in the catalytic function, structural stability, and electron transfer processes of metalloproteins. The types of metals involved can include iron, zinc, copper, magnesium, calcium, or manganese, among others. Examples of metalloproteins are hemoglobin (contains heme-bound iron), cytochrome c (contains heme-bound iron and functions in electron transfer), and carbonic anhydrase (contains zinc and catalyzes the conversion between carbon dioxide and bicarbonate).

Methanosarcina is a genus of archaea, which are single-celled microorganisms that lack a nucleus and other membrane-bound organelles. These archaea are characterized by their ability to produce methane as a metabolic byproduct during the process of anaerobic respiration or fermentation. Methanosarcina species are found in various environments, including freshwater and marine sediments, waste treatment facilities, and the digestive tracts of animals. They are capable of degrading a wide range of organic compounds, such as acetate, methanol, and methylamines, to produce methane. It's important to note that while Methanosarcina species can be beneficial in certain environments, they may also contribute to the release of greenhouse gases, particularly methane, which is a potent contributor to climate change.

... is used as a building block for the synthesis of numerous other commercially available compounds. Methylamine is ... Methylamine arises as a result of putrefaction and is a substrate for methanogenesis. Additionally, methylamine is produced ... Methylamine is an organic compound with a formula of CH3NH2. This colorless gas is a derivative of ammonia, but with one ... Methylamine is sold as a solution in methanol, ethanol, tetrahydrofuran, or water, or as the anhydrous gas in pressurized metal ...
The systematic name of this enzyme class is L-glutamate:methylamine ligase (ADP-forming). This enzyme is also called gamma- ... A new intermediate in the metabolism of methylamine". J. Biol. Chem. 244 (15): 4136-40. PMID 5800436. Portal: Biology v t e (EC ... In enzymology, a glutamate-methylamine ligase (EC 6.3.4.12) is an enzyme that catalyzes the chemical reaction ATP + L-glutamate ... and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine. This enzyme belongs to the family of ...
Methylamine+dehydrogenase+(amicyanin) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ... Methylamine dehydrogenase (amicyanin) (EC 1.4.9.1, amine dehydrogenase, primary-amine dehydrogenase) is an enzyme with ... de Beer R, Duine JA, Frank J, Large PJ (April 1980). "The prosthetic group of methylamine dehydrogenase from Pseudomonas AM1: ... "Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine". The ...
In enzymology, a methylamine-glutamate N-methyltransferase (EC 2.1.1.21) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is methylamine:l-glutamate N-methyltransferase. Other names in common use include N- ... the two substrates of this enzyme are methylamine and l-glutamate, whereas its two products are NH3 and N-methyl-l-glutamate. ... methylglutamate synthase, and methylamine-glutamate methyltransferase. This enzyme participates in methane metabolism. Shaw WV ...
4-methylaminobutanoate+oxidase+(methylamine-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ... 4-methylaminobutanoate oxidase (methylamine-forming) (EC 1.5.3.21, mao (gene)) is an enzyme with systematic name 4- ... methylamine + H2O2 The enzyme participates in the nicotine degradation in soil bacterium Arthrobacter nicotinovorans. Chiribau ...
This enzyme catalyses the following chemical reaction methylamine + [Co(I) methylamine-specific corrinoid protein] ⇌ {\ ... Methylamine---corrinoid+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ... Methylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.248, mtmB (gene), monomethylamine methyltransferase) is an enzyme ... Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases ...
methyl-Co(III)+methylamine-specific+corrinoid+protein):coenzyme+M+methyltransferase at the U.S. National Library of Medicine ... Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.247, methyltransferase 2, MT2, ... This enzyme catalyses the following chemical reaction [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M ⇌ ... methyl-CoM + [Co(I) methylamine-specific corrinoid protein] This enzyme contains zinc. Burke SA, Krzycki JA (August 1995). " ...
"Methylamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a16_535. "Ziram" (PDF ...
... is a weak base and the pKa of the ammonium CH3-NH+ 2-CH3 is 10.73, a value above methylamine (10.64) and ... Corbin D.R.; Schwarz S.; Sonnichsen G.C. (1997). "Methylamines synthesis: A review". Catalysis Today. 37 (2): 71-102. doi: ... Methylamine Trimethylamine "Dimethylamine". NIST Chemistry WebBook. USA: National Institute of Standards and Technology. ... "Methylamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a16_535. ...
3 H2O This reaction coproduces the other methylamines, dimethylamine (CH3)2NH and methylamine CH3NH2. Trimethylamine has also ... Ammonia, NH3 Ammonium, NH4+ Methylamine, (CH3)NH2 Triethylamine (TEA) Merck Index, 11th Edition, 9625. IUPAC Chemical ... "Methylamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a16_535. Ashford, ...
Van Gysel, August B.; Musin, Willy (2000). "Methylamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH ...
They cannot use acetate or methylamines. They grow fastest at temperatures of 30-40 °C. The currently accepted taxonomy is ...
They cannot use acetate or methylamines. They grow most quickly at 30-40 °C. The currently accepted taxonomy is based on the ...
They cannot metabolize acetate, methylamines, or methanol. List of Archaea genera See the NCBI webpage on Methanomicrobium. ...
Kaifu, N.; Kojima, T.; Tagaki, K. (1 June 1975). "Excitation of interstellar methylamine". The Astrophysical Journal. 198: 4. ...
Charles-Adolphe Wurtz obtains methylamine. Louis Pasteur discovers that the racemic form of tartaric acid is a mixture of the ...
... acids or methyl amines; acetogenesis making acetic acid; methanogenesis making methane, and sulfate, nitrite and nitrate ...
These compounds include methanol, methyl amines, formaldehyde, and formate. Several other less common substrates may also be ...
Possible electron donors include methanol, methylamines, dimethylamines, and trimethylamines. Methanohalophilus mahii is ... which is also coded for by the genes used for methylamine methyltransferases. This species was also the first member to have ...
Such one-carbon compounds include methylamines, methanol, and methyl thiols. Only Methanosarcina species possess all three ...
They produce methane from methanol, methylamines, dimethyl sulfide and methanethiol. With the exception of M. thermophila, ...
nov., a coccoid methanogen growing only on methanol and methylamines." Zentralblatt für Bakteriologie Mikrobiologie und Hygiene ...
nov., a coccoid methanogen growing only on methanol and methylamines". Zentralbl. Bakteriol. Parasitenkd. Infektionskr. Hyg. ...
When their accomplice Todd kills a child witness during a methylamine theft, Jesse and Mike sell their share of the methylamine ... P2P and methylamine form an imine intermediate; reduction of this P2P-methylamine imine intermediate is performed using mercury ... The new method Walt chooses is a reductive amination reaction, relying on phenyl-2-propanone and methylamine. On the show, the ... She reluctantly begins supplying Walt and Jesse with methylamine and helps Walt expand his operation overseas. Jesse Plemons as ...
The reaction with methylamine gives fludorex (4). The benzylamine is called SK&F 39728-A Beregi SL, Duhault J (1977). " ...
... methylamines, and reactive metals). "The Chemours Company 2021 Annual Report (Form 10-K)" (PDF). February 17, 2022. "Chemours ...
One other name for buphedrone is phenylacetoethyl-methylamine. Buphedrone as free base is very unstable; it is prone to ...
... is the cation with the formula [N2H5]+. This cation has a methylamine-like structure ([H2N−NH3]+). It can be ...
Produces acetone, carbonyl iron, diethanolamine, isopropanol, methylamine, phenol, etc. Orgsteklo, JSC (previously manufactured ...
and novel Gammaproteobacteria in marine methanol and methylamine metabolism". ISME Journal. 1 (6): 480-491. doi:10.1038/ismej. ...
Methylamine is used as a building block for the synthesis of numerous other commercially available compounds. Methylamine is ... Methylamine arises as a result of putrefaction and is a substrate for methanogenesis. Additionally, methylamine is produced ... Methylamine is an organic compound with a formula of CH3NH2. This colorless gas is a derivative of ammonia, but with one ... Methylamine is sold as a solution in methanol, ethanol, tetrahydrofuran, or water, or as the anhydrous gas in pressurized metal ...
X-ray reduced Paraccocus denitrificans methylamine dehydrogenase N- quinol in complex with amicyanin. ... METHYLAMINE DEHYDROGENASE HEAVY CHAIN. E [auth G],. F [auth H],. G [auth I],. H [auth J]. 386. Paracoccus denitrificans. ... METHYLAMINE DEHYDROGENASE LIGHT CHAIN. I [auth K],. J [auth L],. K [auth M],. L [auth N]. 131. Paracoccus denitrificans. ... Tracking X-Ray-Derived Redox Changes in Crystals of a Methylamine Dehydrogenase/Amicyanin Complex Using Single-Crystal Uv/Vis ...
... CAS 593-51-1 WIKI information includes physical and chemical properties, USES, security data, NMR ... Method for Recycling Methylamine Hydrochloride Mar 11 2021 Methylamine is an organic compound with a formula of CH3NH2. This ... How Can Methylamine Hydrochloride be Recycled? Oct 21 2019 Methylamine, with the chemical formula CH3NH2, is an organic ... Methylamine hydrochloride. 1.2 Synonyms. CH3NH3Cl(MACl) MERCURIALIN HYDROCHLORIDE Methylamine-hydrogenchloride(1/1) ...
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Millimeter and submillimeter wave spectra of 13C methylamine⋆ R. A. Motiyenko1, L. Margulès1, V. V. Ilyushin2, I. A. Smirnov2, ... Predicted (in red) and observed (in blue) rotational spectrum of 13C methylamine between 882 and 908 GHz dominated by cQ-type ... Predicted (in red) and observed (in blue) rotational spectrum of 13C methylamine between 882 and 908 GHz dominated by cQ-type ... Methylamine (CH3NH2) is a light molecule of astrophysical interest, which has an intensive rotational spectrum that extends in ...
Sonqor Methyl Amine. Category: Petrochemical Status: Ongoing Location: Kermanshah Sonqor Industrial Park ...
Methylamine, 1-acetoxy-N-nitroso-N-trideuteromethyl- , C4H8N2O3 , CID 49930 - structure, chemical names, physical and chemical ...
Methylamine is an enogenous amine found in humans. Human urine was found to contain 1.68 to 62.30 mg of methylamine per day.[1] ...
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Adsorption of methylamine on alpha-Al203(0001) and alpha-Cr203(0001) Journal article, 2007 ...
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Methylamine. CH3NH2 (g). -6.67. -21.38. ± 0.27. kJ/mol. 31.05714 ±. 0.00088. 74-89-5*0. ... Methylamine. CH3NH2 (l). -45.41. ± 0.47. kJ/mol. 31.05714 ±. 0.00088. 74-89-5*500. ...
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Global Methylamines Market, Share, Revenue, Size, Global, Research Report, Rate, Price, Industry Trends, Analysis, Outlook , ... 5.1 East Asia Methylamines Consumption by Countries. 5.2 China. 5.3 Japan. 5.4 South Korea. 6 Europe. 6.1 Europe Methylamines ... 3.4 East Asia Methylamines Sales Volume. 3.4.1 East Asia Methylamines Sales Volume Growth Rate (2018-2021). 3.4.2 East Asia ... 3.6 South Asia Methylamines Sales Volume (2018-2021). 3.6.1 South Asia Methylamines Sales Volume Growth Rate (2018-2021). 3.6.2 ...
Turkey exports of Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and ... Turkey exported Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and ... Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and their salts. 2021. ... Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and their salts. 2021. ...
Exporter of Methylamine Hydrochloride offered by Nikava Pharmaceutical Industries, Thane, Maharashtra. ... Methylamine Hydrochloride. We provide high quality Methylamine Hydrochloride. We supply with packing in 25 kg Paper HDPE Lined ... Also known as Mono Methylamine hydrochloride or Methyl Amonium Chloride and use in the manufacture of LOBELIN HCL , API . ... We manufacture Methylamine Hydrochloride and supply it in high quality packing. We provide by 25 kg Paper HDPE Lined Bags with ...
6-bromo-1H-indazol-3-yl)methyl]amine hydrochloride. Formula. C8 H8 Br N3 . Cl H. Molecular Weight. 263. LogP. 1.46. Rotatable ...
Turkey imports of Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and ... Turkey imported Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and ... Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and their salts. 2021. ... Amine-function compounds; acyclic monoamines and their derivatives, methylamine, di- or trimethylamine and their salts. 2021. ...
Hydroxy-PEG-methylamine: high purity Polyethylene Glycol (PEG) linkers with different linker lengths, bearing various reactive ... HomePolyethylene Glycol PEG LinkersMeNH-PEG Hydroxy-PEG-methylamine. Showing all 3 results ...
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METHYL-D3-AMINE HYDROCHLORIDE [7436-22-8],Linear Formula CH2 D3 N . Cl H.Supply advanced organic chemicals.
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CHEMICAL NUMBER: P210-0378 CAS_RN: 56622-54-9 PRODUCT PURITY: 95% PRODUCT QUANTITY: 1g LEAD TIME: 2 WEEKS CONTACT FOR PRICING
How to detect Methylamine. Formula: CH5N , CAS: 74-89-5. Synonyms: methanamine, aminomethane, methylamine (anhydrous), ... View products detecting gaseous Methylamine. TVOC 2 Continuous VOC Gas Detector. TVOC 2 is a fixed, continuous VOC gas detector ... View products detecting gaseous Methylamine. TVOC 2 Continuous VOC Gas Detector. TVOC 2 is a fixed, continuous VOC gas detector ... methylamine (aqueous), monomethylamine. Methyl is a sour gas scavenger used in refining, a precursor in the manufacture of ...
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Email: [email protected] Name: Methylamine hydrochloride. CAS Number :593-51-1… ... Email: [email protected] Name: Methylamine hydrochloride. CAS Number :593-51-1… ... Bulk supply methylamine hydrochloride cas 593-51-1 methylamine hcl (Bagalkot, Karnataka) I am sherry of HUBEI AOKS BIO-TECH CO ... Top sell of Methylamine hydrochloride cas 593-51-1 (Basavakalyan, Karnataka) I am sherry of HUBEI AOKS BIO-TECH CO, Ltd. ...

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