A genus of anaerobic, irregular spheroid-shaped METHANOSARCINALES whose organisms are nonmotile. Endospores are not formed. These archaea derive energy via formation of methane from acetate, methanol, mono-, di-, and trimethylamine, and possibly, carbon monoxide. Organisms are isolated from freshwater and marine environments.
A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.
A phylum of ARCHAEA comprising at least seven classes: Methanobacteria, Methanococci, Halobacteria (extreme halophiles), Archaeoglobi (sulfate-reducing species), Methanopyri, and the thermophiles: Thermoplasmata, and Thermococci.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
Proteins found in any species of archaeon.
A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
Cyclic TETRAPYRROLES based on the corrin skeleton.
An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.
A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
The functional genetic units of ARCHAEA.
An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. Acetylphosphate serves as a high-energy phosphate compound. EC 2.3.1.8.
Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in archaea.
Oxidoreductases that are specific for ALDEHYDES.
Deoxyribonucleic acid that makes up the genetic material of archaea.
'Methylamines' are organic compounds consisting of a methyl group (CH3) linked to an amino group (-NH2), with the general formula of CH3-NH-R, where R can be a hydrogen atom or any organic group, and they exist as colorless gases or liquids at room temperature.
Dimethylamines are organic compounds that contain two methyl groups (-CH3) bonded to a nitrogen atom (N), with the general formula (CH3)2NH. They can act as secondary amines and are commonly used in chemical synthesis, but they are not typically found as natural components in the human body.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
A family of anaerobic METHANOSARCINALES whose cells are mesophilic or thermophilic and appear as irregular spheroid bodies or sheathed rods. These methanogens are found in any anaerobic environment including aquatic sediments, anaerobic sewage digesters and gastrointestinal tracts. There are four genera: METHANOSARCINA, Methanolobus, Methanothrix, and Methanococcoides.
An order of anaerobic methanogens in the kingdom EURYARCHAEOTA. There are two families: METHANOSARCINACEAE and Methanosaetaceae.
Structures within the nucleus of archaeal cells consisting of or containing DNA, which carry genetic information essential to the cell.
Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
One of the three domains of life (the others being BACTERIA and Eukarya), formerly called Archaebacteria under the taxon Bacteria, but now considered separate and distinct. They are characterized by: (1) the presence of characteristic tRNAs and ribosomal RNAs; (2) the absence of peptidoglycan cell walls; (3) the presence of ether-linked lipids built from branched-chain subunits; and (4) their occurrence in unusual habitats. While archaea resemble bacteria in morphology and genomic organization, they resemble eukarya in their method of genomic replication. The domain contains at least four kingdoms: CRENARCHAEOTA; EURYARCHAEOTA; NANOARCHAEOTA; and KORARCHAEOTA.
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
Iodinated hydrocarbons are organic compounds containing carbon and hydrogen atoms, with iodine atoms covalently bonded to them, which are used in medical imaging as radiocontrast agents.
Ribonucleic acid in archaea having regulatory and catalytic roles as well as involvement in protein synthesis.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Immunoglobulins produced in a response to ARCHAEAL ANTIGENS.
The genetic complement of an archaeal organism (ARCHAEA) as represented in its DNA.
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Substances of archaeal origin that have antigenic activity.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Organic esters or salts of sulfonic acid derivatives containing an aliphatic hydrocarbon radical.
Phenazines are nitrogen-containing heterocyclic compounds that have been widely studied for their antibacterial, antifungal, and antiparasitic properties, and can be found in various natural sources such as bacteria and fungi, or synthesized chemically.
Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.
Compounds based on 2-amino-4-hydroxypteridine.
Cobamides are a class of compounds that function as cofactors in various enzymatic reactions, containing a corrin ring similar to vitamin B12, but with different substituents on the benzimidazole moiety, and can be found in certain bacteria and archaea.
Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
A family of anaerobic, coccoid to rod-shaped METHANOBACTERIALES. Cell membranes are composed mainly of polyisoprenoid hydrocarbons ether-linked to glycerol. Its organisms are found in anaerobic habitats throughout nature.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A genus of anaerobic, rod-shaped METHANOBACTERIACEAE. Its organisms are nonmotile and use ammonia as the sole source of nitrogen. These methanogens are found in aquatic sediments, soil, sewage, and the gastrointestinal tract of animals.
A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
A family of anaerobic METHANOMICROBIALES whose cells are coccoid to straight or slightly curved rods. There are six genera.
2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.
A genus of obligate anaerobic METHANOCALDOCOCCACEAE whose organisms are non-motile despite possessing long thin flagella. These methanogens are found in deep-sea vent and other hydrothermal environments.
An enzyme that activates serine with its specific transfer RNA. EC 6.1.1.11.
Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Immobilization patterns and dynamics of acetate-utilizing methanogens immobilized in sterile granular sludge in upflow anaerobic sludge blanket reactors. (1/251)

Sterile granular sludge was inoculated with either Methanosarcina mazeii S-6, Methanosaeta concilii GP-6, or both species in acetate-fed upflow anaerobic sludge blanket (UASB) reactors to investigate the immobilization patterns and dynamics of aceticlastic methanogens in granular sludge. After several months of reactor operation, the methanogens were immobilized, either separately or together. The fastest immobilization was observed in the reactor containing M. mazeii S-6. The highest effluent concentration of acetate was observed in the reactor with only M. mazeii S-6 immobilized, while the lowest effluent concentration of acetate was observed in the reactor where both types of methanogens were immobilized together. No changes were observed in the kinetic parameters (Ks and mumax) of immobilized M. concilii GP-6 or M. mazeii S-6 compared with suspended cultures, indicating that immobilization does not affect the growth kinetics of these methanogens. An enzyme-linked immunosorbent assay using polyclonal antibodies against either M. concilii GP-6 or M. mazeii S-6 showed significant variations in the two methanogenic populations in the different reactors. Polyclonal antibodies were further used to study the spatial distribution of the two methanogens. M. concilii GP-6 was immobilized only on existing support material without any specific pattern. M. mazeii S-6, however, showed a different immobilization pattern: large clumps were formed when the concentration of acetate was high, but where the acetate concentration was low this strain was immobilized on support material as single cells or small clumps. The data clearly show that the two aceticlastic methanogens immobilize differently in UASB systems, depending on the conditions found throughout the UASB reactor.  (+info)

Effects of nickel and cobalt on kinetics of methanol conversion by methanogenic sludge as assessed by on-line CH4 monitoring. (2/251)

When metals were added in a pulse mode to methylotrophic-methanogenic biomass, three methane production rate phases were recognized. Increased concentrations of Ni and Co accelerated the initial exponential and final arithmetic increases in the methane production rate and reduced the temporary decrease in the rate. When Ni and Co were added continuously, the temporary decrease phase was eliminated and the exponential production rate increased. We hypothesize that the temporary decrease in the methane production rate and the final arithmetic increase in the methane production rate were due to micronutrient limitations and that the precipitation-dissolution kinetics of metal sulfides may play a key role in the biovailability of these compounds.  (+info)

Energy conservation by the H2:heterodisulfide oxidoreductase from Methanosarcina mazei Go1: identification of two proton-translocating segments. (3/251)

The membrane-bound H2:heterodisulfide oxidoreductase system of the methanogenic archaeon Methanosarcina mazei Go1 catalyzed the H2-dependent reduction of 2-hydroxyphenazine and the dihydro-2-hydroxyphenazine-dependent reduction of the heterodisulfide of HS-CoM and HS-CoB (CoM-S-S-CoB). Washed inverted vesicles of this organism were found to couple both processes with the transfer of protons across the cytoplasmic membrane. The maximal H+/2e- ratio was 0.9 for each reaction. The electrochemical proton gradient (DeltamicroH+) thereby generated was shown to drive ATP synthesis from ADP plus Pi, exhibiting stoichiometries of 0.25 ATP synthesized per two electrons transported for both partial reactions. ATP synthesis and the generation of DeltamicroH+ were abolished by the uncoupler 3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile (SF 6847). The ATP synthase inhibitor N,N'-dicyclohexylcarbodiimide did not affect H+ translocation but led to an almost complete inhibition of ATP synthesis and decreased the electron transport rates. The latter effect was relieved by the addition of SF 6847. Thus, the energy-conserving systems showed a stringent coupling which resembles the phenomenon of respiratory control. The results indicate that two different proton-translocating segments are present in the H2:heterodisulfide oxidoreductase system; the first involves the 2-hydroxyphenazine-dependent hydrogenase, and the second involves the heterodisulfide reductase.  (+info)

How stable is stable? Function versus community composition. (4/251)

The microbial community dynamics of a functionally stable, well-mixed, methanogenic reactor fed with glucose were analyzed over a 605-day period. The reactor maintained constant pH and chemical oxygen demand removal during this period. Thirty-six rrn clones from each of seven sampling events were analyzed by amplified ribosomal DNA restriction analysis (ARDRA) for the Bacteria and Archaea domains and by sequence analysis of dominant members of the community. Operational taxonomic units (OTUs), distinguished as unique ARDRA patterns, showed reproducible distribution for three sample replicates. The highest diversity was observed in the Bacteria domain. The 16S ribosomal DNA Bacteria clone library contained 75 OTUs, with the dominant OTU accounting for 13% of the total clones, but just 21 Archaea OTUs were found, and the most prominent OTU represented 50% of the clones from the respective library. Succession in methanogenic populations was observed, and two periods were distinguished: in the first, Methanobacterium formicicum was dominant, and in the second, Methanosarcina mazei and a Methanobacterium bryantii-related organism were dominant. Higher variability in Bacteria populations was detected, and the temporal OTU distribution suggested a chaotic pattern. Although dominant OTUs were constantly replaced from one sampling point to the next, phylogenetic analysis indicated that inferred physiologic changes in the community were not as dramatic as were genetic changes. Seven of eight dominant OTUs during the first period clustered with the spirochete group, although a cyclic pattern of substitution occurred among members within this order. A more flexible community structure characterized the second period, since a sequential replacement of a Eubacterium-related organism by an unrelated deep-branched organism and finally by a Propionibacterium-like species was observed. Metabolic differences among the dominant fermenters detected suggest that changes in carbon and electron flow occurred during the stable performance and indicate that an extremely dynamic community can maintain a stable ecosystem function.  (+info)

Purification and catalytic properties of Ech hydrogenase from Methanosarcina barkeri. (5/251)

Methanosarcina barkeri has recently been shown to produce a multisubunit membrane-bound [NiFe] hydrogenase designated Ech (Escherichia coli hydrogenase 3) hydrogenase. In the present study Ech hydrogenase was purified to apparent homogeneity in a high yield. The enzyme preparation obtained only contained the six polypeptides which had previously been shown to be encoded by the ech operon. The purified enzyme was found to contain 0.9 mol of Ni, 11.3 mol of nonheme-iron and 10.8 mol of acid-labile sulfur per mol of enzyme. Using the purified enzyme the kinetic parameters were determined. The enzyme catalyzed the H2 dependent reduction of a M. barkeri 2[4Fe-4S] ferredoxin with a specific activity of 50 U x mg protein-1 at pH 7.0 and exhibited an apparent Km for the ferredoxin of 1 microM. The enzyme also catalyzed hydrogen formation with the reduced ferredoxin as electron donor at a rate of 90 U x mg protein-1 at pH 7.0. The apparent Km for the reduced ferredoxin was 7.5 microM. Reduction or oxidation of the ferredoxin proceeded at similar rates as the reduction or oxidation of oxidized or reduced methylviologen, respectively. The apparent Km for H2 was 5 microM. The kinetic data strongly indicate that the ferredoxin is the physiological electron donor or acceptor of Ech hydrogenase. Ech hydrogenase amounts to about 3% of the total cell protein in acetate-grown, methanol-grown or H2/CO2-grown cells of M. barkeri, as calculated from quantitative Western blot experiments. The function of Ech hydrogenase is ascribed to ferredoxin-linked H2 production coupled to the oxidation of the carbonyl-group of acetyl-CoA to CO2 during growth on acetate, and to ferredoxin-linked H2 uptake coupled to the reduction of CO2 to the redox state of CO during growth on H2/CO2 or methanol.  (+info)

O-Acetylserine sulfhydrylase from Methanosarcina thermophila. (6/251)

Cysteine is the major source of fixed sulfur for the synthesis of sulfur-containing compounds in organisms of the Bacteria and Eucarya domains. Though pathways for cysteine biosynthesis have been established for both of these domains, it is unknown how the Archaea fix sulfur or synthesize cysteine. None of the four archaeal genomes sequenced to date contain open reading frames with identities to either O-acetyl-L-serine sulfhydrylase (OASS) or homocysteine synthase, the only sulfur-fixing enzymes known in nature. We report the purification and characterization of OASS from acetate-grown Methanosarcina thermophila, a moderately thermophilic methanoarchaeon. The purified OASS contained pyridoxal 5'-phosphate and catalyzed the formation of L-cysteine and acetate from O-acetyl-L-serine and sulfide. The N-terminal amino acid sequence has high sequence similarity with other known OASS enzymes from the Eucarya and Bacteria domains. The purified OASS had a specific activity of 129 micromol of cysteine/min/mg, with a K(m) of 500 +/- 80 microM for sulfide, and exhibited positive cooperativity and substrate inhibition with O-acetyl-L-serine. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a single band at 36 kDa, and native gel filtration chromatography indicated a molecular mass of 93 kDa, suggesting that the purified OASS is either a homodimer or a homotrimer. The optimum temperature for activity was between 40 and 60 degrees C, consistent with the optimum growth temperature for M. thermophila. The results of this study provide the first evidence for a sulfur-fixing enzyme in the Archaea domain. The results also provide the first biochemical evidence for an enzyme with the potential for involvement in cysteine biosynthesis in the Archaea.  (+info)

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes? (7/251)

The pathway of cysteine biosynthesis in archaea is still unexplored. Complementation of a cysteine auxotrophic Escherichia coli strain NK3 led to the isolation of the Methanosarcina barkeri cysK gene [encoding O-acetylserine (thiol)-lyase-A], which displays great similarity to bacterial cysK genes. Adjacent to cysK is an open reading frame orthologous to bacterial cysE (serine transacetylase) genes. These two genes could account for cysteine biosynthesis in this archaeon. Analysis of recent genome data revealed the presence of bacteria-like cysM genes [encoding O-acetylserine (thiol)-lyase-B] in Pyrococcus spp., Sulfolobus solfataricus, and Thermoplasma acidophilum. However, no orthologs for these genes can be found in Methanococcus jannaschii, Methanobacterium thermoautotrophicum, and Archaeoglobus fulgidus, implying the existence of unrecognizable genes for the same function or a different cysteine biosynthesis pathway.  (+info)

Effect of temperature on stability and activity of elongation factor 2 proteins from Antarctic and thermophilic methanogens. (8/251)

Despite the presence and abundance of archaea in low-temperature environments, little information is available regarding their physiological and biochemical properties. In order to investigate the adaptation of archaeal proteins to low temperatures, we purified and characterized the elongation factor 2 (EF-2) protein from the Antarctic methanogen Methanococcoides burtonii, which was expressed in Escherichia coli, and compared it to the recombinant EF-2 protein from a phylogenetically related thermophile, Methanosarcina thermophila. Using differential scanning calorimetry to assess protein stability and enzyme assays for the intrinsic GTPase activity, we identified biochemical and biophysical properties that are characteristic of the cold-adapted protein. This includes a higher activity at low temperatures caused by a decrease of the activation energy necessary for GTP hydrolysis and a decreased activation energy for the irreversible denaturation of the protein, which indicates a less thermostable structure. Comparison of the in vitro properties of the proteins with the temperature-dependent characteristics of growth of the organisms indicates that additional cytoplasmic factors are likely to be important for the complete thermal adaptation of the proteins in vivo. This is the first study to address thermal adaptation of proteins from a free-living, cold-adapted archaeon, and our results indicate that the ability of the Antarctic methanogen to adapt to the cold is likely to involve protein structural changes.  (+info)

Methanosarcina is a genus of archaea, which are single-celled microorganisms that lack a nucleus and other membrane-bound organelles. These archaea are characterized by their ability to produce methane as a metabolic byproduct during the process of anaerobic respiration or fermentation. Methanosarcina species are found in various environments, including freshwater and marine sediments, waste treatment facilities, and the digestive tracts of animals. They are capable of degrading a wide range of organic compounds, such as acetate, methanol, and methylamines, to produce methane. It's important to note that while Methanosarcina species can be beneficial in certain environments, they may also contribute to the release of greenhouse gases, particularly methane, which is a potent contributor to climate change.

'Methanosarcina barkeri' is not a medical term, but a species name in the domain of microbiology. It refers to a type of archaea (single-celled organisms) that is capable of methanogenesis - producing methane as a metabolic byproduct. This microorganism is commonly found in anaerobic environments such as wetlands, digestive tracts of animals, and sewage sludge. It's not something that typically has a direct medical definition or relevance, unless in the context of specific research or environmental/industrial settings.

Euryarchaeota is a phylum within the domain Archaea, which consists of a diverse group of microorganisms that are commonly found in various environments such as soil, oceans, and the digestive tracts of animals. This group includes methanogens, which are archaea that produce methane as a metabolic byproduct, and extreme halophiles, which are archaea that thrive in highly saline environments.

The name Euryarchaeota comes from the Greek words "eury," meaning wide or broad, and "archaios," meaning ancient or primitive. This name reflects the phylum's diverse range of habitats and metabolic capabilities.

Euryarchaeota are characterized by their unique archaeal-type cell walls, which contain a variety of complex polysaccharides and proteins. They also have a distinct type of intracellular membrane called the archaellum, which is involved in motility. Additionally, Euryarchaeota have a unique genetic code that differs from that of bacteria and eukaryotes, with some codons specifying different amino acids.

Overall, Euryarchaeota are an important group of archaea that play a significant role in global carbon and nitrogen cycles, as well as in the breakdown of organic matter in various environments.

Methane is not a medical term, but it is a chemical compound that is often mentioned in the context of medicine and health. Medically, methane is significant because it is one of the gases produced by anaerobic microorganisms during the breakdown of organic matter in the gut, leading to conditions such as bloating, cramping, and diarrhea. Excessive production of methane can also be a symptom of certain digestive disorders like irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO).

In broader terms, methane is a colorless, odorless gas that is the primary component of natural gas. It is produced naturally by the decomposition of organic matter in anaerobic conditions, such as in landfills, wetlands, and the digestive tracts of animals like cows and humans. Methane is also a potent greenhouse gas with a global warming potential 25 times greater than carbon dioxide over a 100-year time frame.

Archaeal proteins are proteins that are encoded by the genes found in archaea, a domain of single-celled microorganisms. These proteins are crucial for various cellular functions and structures in archaea, which are adapted to survive in extreme environments such as high temperatures, high salt concentrations, and low pH levels.

Archaeal proteins share similarities with both bacterial and eukaryotic proteins, but they also have unique features that distinguish them from each other. For example, many archaeal proteins contain unusual amino acids or modifications that are not commonly found in other organisms. Additionally, the three-dimensional structures of some archaeal proteins are distinct from their bacterial and eukaryotic counterparts.

Studying archaeal proteins is important for understanding the biology of these unique organisms and for gaining insights into the evolution of life on Earth. Furthermore, because some archaea can survive in extreme environments, their proteins may have properties that make them useful in industrial and medical applications.

Methanol, also known as methyl alcohol or wood alcohol, is a volatile, colorless, flammable liquid with a distinctive odor similar to that of ethanol (drinking alcohol). It is used in various industrial applications such as the production of formaldehyde, acetic acid, and other chemicals. In the medical field, methanol is considered a toxic alcohol that can cause severe intoxication and metabolic disturbances when ingested or improperly consumed. Methanol poisoning can lead to neurological symptoms, blindness, and even death if not treated promptly and effectively.

Corrinoids are a class of compounds that include vitamin B12 and its analogs. Vitamin B12 is an essential nutrient for humans and other animals, playing a critical role in the synthesis of DNA, the maintenance of the nervous system, and the metabolism of fatty acids and amino acids.

The corrinoid ring is the structural backbone of vitamin B12 and its analogs. It is a complex, planar molecule made up of four pyrrole rings joined together in a macrocycle. The corrinoid ring contains a central cobalt ion, which can form coordination bonds with various ligands, including organic groups such as methyl, hydroxo, and cyano.

Corrinoids can be found in a wide variety of foods, including meat, dairy products, fish, eggs, and some fortified plant-based foods. They are also produced by certain bacteria, which can synthesize the corrinoid ring and the cobalt ion de novo. Some corrinoids have biological activity similar to vitamin B12, while others do not.

In addition to their role in human nutrition, corrinoids are also used in industrial applications, such as the production of antibiotics and other pharmaceuticals. They are also used as catalysts in chemical reactions, due to their ability to form stable coordination complexes with various ligands.

Acetate kinase is an enzyme that catalyzes the reversible phosphorylation of acetate to form acetyl phosphate and ADP (adenosine diphosphate) from ATP (adenosine triphosphate). The reaction is as follows:

Acetate + ATP -> Acetyl phosphate + ADP

This enzyme plays a role in the metabolism of certain bacteria and archaea, where it helps to generate energy in the form of ATP. It is not typically found in humans or other mammals.

Mesna is a medication used in the prevention and treatment of hemorrhagic cystitis (inflammation and bleeding of the bladder) caused by certain chemotherapy drugs, specifically ifosfamide and cyclophosphamide. Mesna works by neutralizing the toxic metabolites of these chemotherapy agents, which can cause bladder irritation and damage.

Mesna is administered intravenously (into a vein) along with ifosfamide or cyclophosphamide, and it may also be given as a separate infusion after the chemotherapy treatment. The dosage and timing of Mesna administration are determined by the healthcare provider based on the patient's weight, kidney function, and the dose of chemotherapy received.

It is important to note that Mesna does not have any direct anticancer effects and is used solely to manage the side effects of chemotherapy.

I'm happy to help! However, I believe there might be a slight mistake in your question. "Archaeal" is not a term used to describe genes but rather a group of single-celled organisms that are classified as archaea.

Archaea are one of the three domains of life, along with bacteria and eukaryotes (which include plants, animals, and fungi). Archaea are unique because they share characteristics with both bacteria and eukaryotes, but they also have many features that are distinctly their own. For example, archaea have a different cell membrane structure than bacteria and eukaryotes, which allows them to thrive in extreme environments such as hot springs, salt mines, and deep-sea vents.

Genes, on the other hand, are segments of DNA that contain the instructions for making proteins or performing other important functions in an organism's cells. All living organisms, including archaea, have genes that are passed down from generation to generation. Archaeal genes are made up of the same four nucleotides (A, T, C, and G) as bacterial and eukaryotic genes, and they code for proteins and RNA molecules that are essential for the survival and reproduction of archaea.

So, to summarize, there is no specific definition for "Archaeal genes" because "archaeal" is not a term used to describe genes. However, we can say that archaeal genes are segments of DNA that contain the instructions for making proteins and performing other important functions in archaea.

Phosphate Acetyltransferase (PAT) is an enzyme involved in the metabolism of certain amino acids. It catalyzes the transfer of a phosphate group from acetyl phosphate to a variety of acceptor molecules, including carbon, nitrogen, and sulfur nucleophiles. This reaction plays a crucial role in several biochemical pathways, such as the biosynthesis of certain amino acids, vitamins, and cofactors.

The systematic name for this enzyme is acetylphosphate-protein phosphotransferase. It belongs to the family of transferases, specifically those transferring phosphorus-containing groups. The gene that encodes this enzyme in humans is called PAT1 or CABYR. Defects in this gene have been associated with certain neurological disorders.

Acetates, in a medical context, most commonly refer to compounds that contain the acetate group, which is an functional group consisting of a carbon atom bonded to two hydrogen atoms and an oxygen atom (-COO-). An example of an acetate is sodium acetate (CH3COONa), which is a salt formed from acetic acid (CH3COOH) and is often used as a buffering agent in medical solutions.

Acetates can also refer to a group of medications that contain acetate as an active ingredient, such as magnesium acetate, which is used as a laxative, or calcium acetate, which is used to treat high levels of phosphate in the blood.

In addition, acetates can also refer to a process called acetylation, which is the addition of an acetyl group (-COCH3) to a molecule. This process can be important in the metabolism and regulation of various substances within the body.

Gene expression regulation in archaea refers to the complex cellular processes that control the transcription and translation of genes into functional proteins. This regulation is crucial for the survival and adaptation of archaea to various environmental conditions.

Archaea, like bacteria and eukaryotes, use a variety of mechanisms to regulate gene expression, including:

1. Transcriptional regulation: This involves controlling the initiation, elongation, and termination of transcription by RNA polymerase. Archaea have a unique transcription machinery that is more similar to eukaryotic RNA polymerases than bacterial ones. Transcriptional regulators, such as activators and repressors, bind to specific DNA sequences near the promoter region to modulate transcription.
2. Post-transcriptional regulation: This includes processes like RNA processing, modification, and degradation that affect mRNA stability and translation efficiency. Archaea have a variety of RNA-binding proteins and small non-coding RNAs (sRNAs) that play crucial roles in post-transcriptional regulation.
3. Translational regulation: This involves controlling the initiation, elongation, and termination of translation by ribosomes. Archaea use a unique set of translation initiation factors and tRNA modifications to regulate protein synthesis.
4. Post-translational regulation: This includes processes like protein folding, modification, and degradation that affect protein stability and function. Archaea have various chaperones, proteases, and modifying enzymes that participate in post-translational regulation.

Overall, gene expression regulation in archaea is a highly dynamic and coordinated process involving multiple layers of control to ensure proper gene expression under changing environmental conditions.

Aldehyde oxidoreductases are a class of enzymes that catalyze the oxidation of aldehydes to carboxylic acids using NAD+ or FAD as cofactors. They play a crucial role in the detoxification of aldehydes generated from various metabolic processes, such as lipid peroxidation and alcohol metabolism. These enzymes are widely distributed in nature and have been identified in bacteria, yeast, plants, and animals.

The oxidation reaction catalyzed by aldehyde oxidoreductases involves the transfer of electrons from the aldehyde substrate to the cofactor, resulting in the formation of a carboxylic acid and reduced NAD+ or FAD. The enzymes are classified into several families based on their sequence similarity and cofactor specificity.

One of the most well-known members of this family is alcohol dehydrogenase (ADH), which catalyzes the oxidation of alcohols to aldehydes or ketones as part of the alcohol metabolism pathway. Another important member is aldehyde dehydrogenase (ALDH), which further oxidizes the aldehydes generated by ADH to carboxylic acids, thereby preventing the accumulation of toxic aldehydes in the body.

Deficiencies in ALDH enzymes have been linked to several human diseases, including alcoholism and certain types of cancer. Therefore, understanding the structure and function of aldehyde oxidoreductases is essential for developing new therapeutic strategies to treat these conditions.

Archaeal DNA refers to the genetic material present in archaea, a domain of single-celled microorganisms lacking a nucleus. Like bacteria, archaea have a single circular chromosome that contains their genetic information. However, archaeal DNA is significantly different from bacterial and eukaryotic DNA in terms of its structure and composition.

Archaeal DNA is characterized by the presence of unique modifications such as methylation patterns, which help distinguish it from other types of DNA. Additionally, archaea have a distinct set of genes involved in DNA replication, repair, and recombination, many of which are more similar to those found in eukaryotes than bacteria.

One notable feature of archaeal DNA is its resistance to environmental stressors such as extreme temperatures, pH levels, and salt concentrations. This allows archaea to thrive in some of the most inhospitable environments on Earth, including hydrothermal vents, acidic hot springs, and highly saline lakes.

Overall, the study of archaeal DNA has provided valuable insights into the evolutionary history of life on Earth and the unique adaptations that allow these organisms to survive in extreme conditions.

Methylamines are organic compounds that contain a methyl group (CH3) and an amino group (-NH2). They have the general formula of CH3-NH-R, where R can be a hydrogen atom or any organic group. Methylamines are derivatives of ammonia (NH3), in which one or more hydrogen atoms have been replaced by methyl groups.

There are several types of methylamines, including:

1. Methylamine (CH3-NH2): This is the simplest methylamine and is a colorless gas at room temperature with a strong odor. It is highly flammable and reactive.
2. Dimethylamine (CH3)2-NH: This is a colorless liquid at room temperature with an unpleasant fishy odor. It is less reactive than methylamine but still highly flammable.
3. Trimethylamine (CH3)3-N: This is a colorless liquid at room temperature that has a strong, unpleasant odor often described as "fishy." It is less reactive than dimethylamine and is used in various industrial applications.

Methylamines are used in the production of various chemicals, including pesticides, dyes, and pharmaceuticals. They can also be found naturally in some foods and are produced by certain types of bacteria in the body. Exposure to high levels of methylamines can cause irritation to the eyes, skin, and respiratory tract, and prolonged exposure can lead to more serious health effects.

Dimethylamine is an organic compound with the formula (CH3)2NH. It is a colorless gas that is highly soluble in water and polar solvents. Dimethylamine is a derivative of ammonia (NH3) in which two hydrogen atoms are replaced by methyl groups (CH3).

Dimethylamines, in medical terminology, typically refer to compounds that contain the functional group -N(CH3)2. These compounds can have various biological activities and may be used as drugs or therapeutic agents. For example, dimethylamine is a metabolite of choline, a nutrient important for brain function.

However, it's worth noting that "dimethylamines" is not typically used as a medical term to describe a specific condition or diagnosis. If you have any concerns about exposure to dimethylamine or its potential health effects, it would be best to consult with a healthcare professional.

Methyltransferases are a class of enzymes that catalyze the transfer of a methyl group (-CH3) from a donor molecule to an acceptor molecule, which is often a protein, DNA, or RNA. This transfer of a methyl group can modify the chemical and physical properties of the acceptor molecule, playing a crucial role in various cellular processes such as gene expression, signal transduction, and DNA repair.

In biochemistry, methyltransferases are classified based on the type of donor molecule they use for the transfer of the methyl group. The most common methyl donor is S-adenosylmethionine (SAM), a universal methyl group donor found in many organisms. Methyltransferases that utilize SAM as a cofactor are called SAM-dependent methyltransferases.

Abnormal regulation or function of methyltransferases has been implicated in several diseases, including cancer and neurological disorders. Therefore, understanding the structure, function, and regulation of these enzymes is essential for developing targeted therapies to treat these conditions.

Methanosarcinaceae is a family of archaea within the order Methanosarcinales. These organisms are known for their ability to produce methane as a metabolic byproduct, specifically through the process of methanogenesis. They are commonly found in anaerobic environments such as wetlands, digestive tracts of animals, and sewage treatment facilities.

Methanosarcinaceae species are unique among methanogens because they can utilize a variety of substrates for methane production, including acetate, methanol, and carbon dioxide with hydrogen. This versatility allows them to thrive in diverse anaerobic habitats. Some notable genera within this family include Methanosarcina, Methanosaeta, and Methanothrix.

It is important to note that methanogens like those found in Methanosarcinaceae play a significant role in the global carbon cycle, contributing to greenhouse gas emissions and climate change. Additionally, they have potential applications in biotechnology for waste treatment and biofuel production.

Methanosarcinales is an order of methanogenic archaea within the phylum Euryarchaeota. These are microorganisms that produce methane as a metabolic byproduct in anaerobic environments. Members of this order are distinguished by their ability to use multiple substrates for methanogenesis, including acetate, methanol, and methylamines, in addition to carbon dioxide and hydrogen. They often form part of the microbial community in habitats such as wetlands, digestive tracts of animals, and anaerobic waste treatment systems.

Archaeal chromosomes refer to the genetic material present in Archaea, a domain of single-celled microorganisms. Like bacteria and eukaryotes, Archaea have their genetic material organized into a single circular chromosome, which is typically smaller than bacterial chromosomes. The archaeal chromosome contains all the genetic information necessary for the organism's survival, including genes coding for proteins, RNA molecules, and regulatory elements that control gene expression.

Archaeal chromosomes are structurally similar to bacterial chromosomes, with a histone-like protein called histone-like protein A (HLP) that helps compact the DNA into a more condensed form. However, archaeal chromosomes also share some features with eukaryotic chromosomes, such as the presence of nucleosome-like structures and the use of similar mechanisms for DNA replication and repair.

Overall, archaeal chromosomes are an important area of study in molecular biology, as they provide insights into the evolution and diversity of life on Earth.

Ferredoxins are iron-sulfur proteins that play a crucial role in electron transfer reactions in various biological systems, particularly in photosynthesis and nitrogen fixation. They contain one or more clusters of iron and sulfur atoms (known as the iron-sulfur cluster) that facilitate the movement of electrons between different molecules during metabolic processes.

Ferredoxins have a relatively simple structure, consisting of a polypeptide chain that binds to the iron-sulfur cluster. This simple structure allows ferredoxins to participate in a wide range of redox reactions and makes them versatile electron carriers in biological systems. They can accept electrons from various donors and transfer them to different acceptors, depending on the needs of the cell.

In photosynthesis, ferredoxins play a critical role in the light-dependent reactions by accepting electrons from photosystem I and transferring them to NADP+, forming NADPH. This reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) is then used in the Calvin cycle for carbon fixation and the production of glucose.

In nitrogen fixation, ferredoxins help transfer electrons to the nitrogenase enzyme complex, which reduces atmospheric nitrogen gas (N2) into ammonia (NH3), making it available for assimilation by plants and other organisms.

Overall, ferredoxins are essential components of many metabolic pathways, facilitating electron transfer and energy conversion in various biological systems.

Archaea are a domain of single-celled microorganisms that lack membrane-bound nuclei and other organelles. They are characterized by the unique structure of their cell walls, membranes, and ribosomes. Archaea were originally classified as bacteria, but they differ from bacteria in several key ways, including their genetic material and metabolic processes.

Archaea can be found in a wide range of environments, including some of the most extreme habitats on Earth, such as hot springs, deep-sea vents, and highly saline lakes. Some species of Archaea are able to survive in the absence of oxygen, while others require oxygen to live.

Archaea play important roles in global nutrient cycles, including the nitrogen cycle and the carbon cycle. They are also being studied for their potential role in industrial processes, such as the production of biofuels and the treatment of wastewater.

Acetic acid is an organic compound with the chemical formula CH3COOH. It is a colorless liquid with a pungent, vinegar-like smell and is the main component of vinegar. In medical terms, acetic acid is used as a topical antiseptic and antibacterial agent, particularly for the treatment of ear infections, external genital warts, and nail fungus. It can also be used as a preservative and solvent in some pharmaceutical preparations.

I'd be happy to help! However, it seems there might be a slight confusion in your question. Hydrocarbons and iodinated compounds are two different types of chemical substances.

Hydrocarbons refer to organic compounds consisting entirely of hydrogen and carbon atoms. They can be categorized into several types, such as alkanes, alkenes, alkynes, and aromatic hydrocarbons, based on their structure and properties.

On the other hand, iodinated compounds are organic or inorganic molecules containing iodine atoms. These compounds have various applications, especially in medical imaging and therapy, such as radioactive iodine therapy for thyroid cancer and the use of iodinated contrast agents in X-ray and CT scans.

There isn't a specific category called "iodinated hydrocarbons" since hydrocarbons don't inherently contain iodine. However, it is possible to create molecules that combine both hydrocarbon structures and iodine atoms. An example of such a compound would be iodinated alkanes, where iodine atoms replace some hydrogen atoms in an alkane molecule.

So, if you're looking for a medical definition related to iodinated compounds, I can provide that. If you meant something else, please let me know!

Archaeal RNA refers to the Ribonucleic acid (RNA) molecules that are present in archaea, which are a domain of single-celled microorganisms. RNA is a nucleic acid that plays a crucial role in various biological processes, such as protein synthesis, gene expression, and regulation of cellular activities.

Archaeal RNAs can be categorized into different types based on their functions, including:

1. Messenger RNA (mRNA): It carries genetic information from DNA to the ribosome, where it is translated into proteins.
2. Transfer RNA (tRNA): It helps in translating the genetic code present in mRNA into specific amino acids during protein synthesis.
3. Ribosomal RNA (rRNA): It is a structural and functional component of ribosomes, where protein synthesis occurs.
4. Non-coding RNA: These are RNAs that do not code for proteins but have regulatory functions in gene expression and other cellular processes.

Archaeal RNAs share similarities with both bacterial and eukaryotic RNAs, but they also possess unique features that distinguish them from the other two domains of life. For example, archaeal rRNAs contain unique sequence motifs and secondary structures that are not found in bacteria or eukaryotes. These differences suggest that archaeal RNAs have evolved to adapt to the extreme environments where many archaea live.

Overall, understanding the structure, function, and evolution of archaeal RNA is essential for gaining insights into the biology of these unique microorganisms and their roles in various cellular processes.

Oxidoreductases are a class of enzymes that catalyze oxidation-reduction reactions, which involve the transfer of electrons from one molecule (the reductant) to another (the oxidant). These enzymes play a crucial role in various biological processes, including energy production, metabolism, and detoxification.

The oxidoreductase-catalyzed reaction typically involves the donation of electrons from a reducing agent (donor) to an oxidizing agent (acceptor), often through the transfer of hydrogen atoms or hydride ions. The enzyme itself does not undergo any permanent chemical change during this process, but rather acts as a catalyst to lower the activation energy required for the reaction to occur.

Oxidoreductases are classified and named based on the type of electron donor or acceptor involved in the reaction. For example, oxidoreductases that act on the CH-OH group of donors are called dehydrogenases, while those that act on the aldehyde or ketone groups are called oxidases. Other examples include reductases, peroxidases, and catalases.

Understanding the function and regulation of oxidoreductases is important for understanding various physiological processes and developing therapeutic strategies for diseases associated with impaired redox homeostasis, such as cancer, neurodegenerative disorders, and cardiovascular disease.

Antibodies are proteins produced by the immune system in response to the presence of foreign substances, such as bacteria, viruses, or other harmful agents. They are capable of recognizing and binding to specific antigens (molecules on the surface of these agents) in order to neutralize or eliminate them from the body.

Archaeal antibodies, also known as archaeal immunoglobulins, are a type of antibody found in certain species of Archaea, a domain of single-celled microorganisms that are distinct from bacteria and eukaryotes (organisms with complex cells). Unlike the antibodies produced by animals, which consist of two heavy chains and two light chains, archaeal antibodies are composed of four identical subunits, each containing a variable region that is responsible for recognizing and binding to specific antigens.

Archaeal antibodies have attracted interest from researchers due to their unique properties and potential applications in various fields, including medicine and biotechnology. For example, they have been shown to be highly stable under extreme conditions, such as high temperatures and acidic or alkaline environments, making them potentially useful for use in harsh industrial or medical settings. Additionally, the study of archaeal antibodies has provided insights into the evolution of the immune system and the molecular mechanisms underlying antigen recognition and binding.

An archaeal genome refers to the complete set of genetic material or DNA present in an archaea, a single-celled microorganism that is found in some of the most extreme environments on Earth. The genome of an archaea contains all the information necessary for its survival, including the instructions for building proteins and other essential molecules, as well as the regulatory elements that control gene expression.

Archaeal genomes are typically circular in structure and range in size from about 0.5 to over 5 million base pairs. They contain genes that are similar to those found in bacteria and eukaryotes, as well as unique genes that are specific to archaea. The study of archaeal genomes has provided valuable insights into the evolutionary history of life on Earth and has helped scientists understand the adaptations that allow these organisms to thrive in such harsh environments.

Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that is slightly less dense than air. It is toxic to hemoglobic animals when encountered in concentrations above about 35 ppm. This compound is a product of incomplete combustion of organic matter, and is a major component of automobile exhaust.

Carbon monoxide is poisonous because it binds to hemoglobin in red blood cells much more strongly than oxygen does, forming carboxyhemoglobin. This prevents the transport of oxygen throughout the body, which can lead to suffocation and death. Symptoms of carbon monoxide poisoning include headache, dizziness, weakness, nausea, vomiting, confusion, and disorientation. Prolonged exposure can lead to unconsciousness and death.

Carbon monoxide detectors are commonly used in homes and other buildings to alert occupants to the presence of this dangerous gas. It is important to ensure that these devices are functioning properly and that they are placed in appropriate locations throughout the building. Additionally, it is essential to maintain appliances and heating systems to prevent the release of carbon monoxide into living spaces.

I'm sorry for any confusion, but "Hydrogen" is not a medical term. It is a chemical element with the symbol H and atomic number 1. It is the lightest and most abundant chemical element in the universe, making up about 75% of its elemental mass.

In a medical context, hydrogen can be discussed in terms of molecular hydrogen (H2) which has been studied for potential therapeutic benefits. Some research explores its use as an antioxidant and anti-inflammatory agent, but more studies are needed to confirm these effects and understand the mechanisms behind them.

Archaeal antigens refer to molecules or structures on the surface of archaea that can stimulate an immune response in a host organism. Archaea are single-celled microorganisms that are distinct from bacteria and eukaryotes. They have unique cell wall components, such as pseudopeptidoglycan and surface layer proteins (S-layers), which can serve as antigens. Additionally, archaeal flagellins, the structural subunits of archaeal flagella, can also act as antigens. These antigens play a crucial role in the interaction between archaea and their hosts, including potential pathogenic interactions, as well as in the development of vaccines and immunotherapies against archaeal infections.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Alkanesulfonates are organic compounds that consist of a hydrocarbon chain, typically consisting of alkane molecules, which is bonded to a sulfonate group. The sulfonate group (-SO3-) consists of a sulfur atom bonded to three oxygen atoms, with one of the oxygen atoms carrying a negative charge.

Alkanesulfonates are commonly used as detergents and surfactants due to their ability to reduce surface tension and improve the wetting, emulsifying, and dispersing properties of liquids. They are also used in various industrial applications, such as in the production of paper, textiles, and leather.

In medical terms, alkanesulfonates may be used as topical antimicrobial agents or as ingredients in personal care products. However, some alkanesulfonates have been found to have potential health and environmental hazards, such as irritation of the skin and eyes, respiratory effects, and potential toxicity to aquatic life. Therefore, their use is subject to regulatory oversight and safety assessments.

Phenazines are a class of heterocyclic aromatic organic compounds that consist of two nitrogen atoms connected by a five-membered ring. They are naturally occurring in various species of bacteria and fungi, where they play a role in chemical defense and communication. Some phenazines have been found to have antibiotic, antifungal, and antiparasitic properties. Synthetic phenazines are also used in various industrial applications, such as dyes and pigments, and as components in some pharmaceuticals and agrochemicals.

Alkanesulfonic acids are a type of organic compound that consist of an alkane chain, which is a saturated hydrocarbon, with a sulfonic acid group (-SO3H) attached to one end of the chain. The general formula for an alkanesulfonic acid is CnH2n+1SO3H, where n represents the number of carbon atoms in the alkane chain.

Alkanesulfonic acids are strong acids and are highly soluble in water. They are commonly used as detergents, catalysts, and intermediates in the synthesis of other chemicals. Some examples of alkanesulfonic acids include methanesulfonic acid (CH3SO3H), ethanesulfonic acid (C2H5SO3H), and p-toluensulfonic acid (C6H4CH3SO3H).

Pterins are a group of naturally occurring pigments that are derived from purines. They are widely distributed in various organisms, including bacteria, fungi, and animals. In humans, pterins are primarily found in the eye, skin, and hair. Some pterins have been found to play important roles as cofactors in enzymatic reactions and as electron carriers in metabolic pathways.

Abnormal levels of certain pterins can be indicative of genetic disorders or other medical conditions. For example, an excess of biopterin, a type of pterin, is associated with phenylketonuria (PKU), a genetic disorder that affects the body's ability to metabolize the amino acid phenylalanine. Similarly, low levels of neopterin, another type of pterin, can be indicative of immune system dysfunction or certain types of cancer.

Medical professionals may measure pterin levels in blood, urine, or other bodily fluids to help diagnose and monitor these conditions.

Cobamides are a class of compounds that are structurally related to vitamin B12 (cobalamin). They consist of a corrin ring, which is a large heterocyclic ring made up of four pyrrole rings, and a cobalt ion in the center. The lower axial ligand of the cobalt ion can be a variety of different groups, including cyano, hydroxo, methyl, or 5'-deoxyadenosyl groups.

Cobamides are involved in a number of important biological processes, including the synthesis of amino acids and nucleotides, the metabolism of fatty acids and cholesterol, and the regulation of gene expression. They function as cofactors for enzymes called cobamide-dependent methyltransferases, which transfer methyl groups (CH3) from one molecule to another.

Cobamides are found in a wide variety of organisms, including bacteria, archaea, and eukaryotes. In humans, the most important cobamide is vitamin B12, which is essential for the normal functioning of the nervous system and the production of red blood cells. Vitamin B12 deficiency can lead to neurological problems and anemia.

Fluoroacetates are organic compounds that contain a fluorine atom and an acetic acid group. The most well-known and notorious compound in this family is sodium fluoroacetate, also known as 1080 or compound 1080, which is a potent metabolic poison. It works by interfering with the citric acid cycle, a critical process that generates energy in cells. Specifically, fluoroacetates are converted into fluorocitrate, which inhibits an enzyme called aconitase, leading to disruption of cellular metabolism and ultimately cell death.

Fluoroacetates have been used as rodenticides and pesticides, but their use is highly regulated due to their high toxicity to non-target species, including humans. Exposure to fluoroacetates can cause a range of symptoms, including nausea, vomiting, seizures, and cardiac arrest, and can be fatal if not treated promptly.

Multienzyme complexes are specialized protein structures that consist of multiple enzymes closely associated or bound together, often with other cofactors and regulatory subunits. These complexes facilitate the sequential transfer of substrates along a series of enzymatic reactions, also known as a metabolic pathway. By keeping the enzymes in close proximity, multienzyme complexes enhance reaction efficiency, improve substrate specificity, and maintain proper stoichiometry between different enzymes involved in the pathway. Examples of multienzyme complexes include the pyruvate dehydrogenase complex, the citrate synthase complex, and the fatty acid synthetase complex.

Methanobacteriaceae is a family of archaea within the order Methanobacteriales. These are obligate anaerobes that obtain energy for growth by reducing carbon dioxide to methane, a process called methanogenesis. They are commonly found in anaerobic environments such as wetlands, digestive tracts of animals, and sewage sludge. Some species are thermophilic, meaning they prefer higher temperatures, while others are mesophilic, growing best at moderate temperatures. Methanobacteriaceae are important contributors to the global carbon cycle and have potential applications in bioremediation and bioenergy production.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

Methanobacterium is a genus of archaea belonging to the order Methanobacteriales and the family Methanobacteriaceae. They are commonly known as methanogenic bacteria, but they are not true bacteria; instead, they belong to the domain Archaea. These organisms are characterized by their ability to produce methane as a metabolic end-product in anaerobic conditions. They are typically found in environments like swamps, wetlands, digestive tracts of animals, and sewage sludge. The cells of Methanobacterium are usually rod-shaped and may appear gram-positive or gram-variable. Some species are capable of forming endospores.

Iron-sulfur proteins are a group of metalloproteins that contain iron and sulfur atoms in their active centers. These clusters of iron and sulfur atoms, also known as iron-sulfur clusters, can exist in various forms, including Fe-S, 2Fe-2S, 3Fe-4S, and 4Fe-4S structures. The iron atoms are coordinated to the protein through cysteine residues, while the sulfur atoms can be in the form of sulfide (S2-) or sulfane (-S-).

These proteins play crucial roles in many biological processes, such as electron transfer, redox reactions, and enzyme catalysis. They are found in various organisms, from bacteria to humans, and are involved in a wide range of cellular functions, including energy metabolism, photosynthesis, nitrogen fixation, and DNA repair.

Iron-sulfur proteins can be classified into several categories based on their structure and function, such as ferredoxins, Rieske proteins, high-potential iron-sulfur proteins (HiPIPs), and radical SAM enzymes. Dysregulation or mutations in iron-sulfur protein genes have been linked to various human diseases, including neurodegenerative disorders, cancer, and mitochondrial disorders.

Riboflavin, also known as vitamin B2, is a water-soluble vitamin that plays a crucial role in energy production and cellular function, growth, and development. It is essential for the metabolism of carbohydrates, fats, and proteins, and it helps to maintain healthy skin, hair, and nails. Riboflavin is involved in the production of energy by acting as a coenzyme in various redox reactions. It also contributes to the maintenance of the mucous membranes of the digestive tract and promotes iron absorption.

Riboflavin can be found in a variety of foods, including milk, cheese, leafy green vegetables, liver, kidneys, legumes, yeast, mushrooms, and almonds. It is sensitive to light and heat, so exposure to these elements can lead to its degradation and loss of vitamin activity.

Deficiency in riboflavin is rare but can occur in individuals with poor dietary intake or malabsorption disorders. Symptoms of riboflavin deficiency include inflammation of the mouth and tongue, anemia, skin disorders, and neurological symptoms such as confusion and mood changes. Riboflavin supplements are available for those who have difficulty meeting their daily requirements through diet alone.

Methanomicrobiaceae is a family of archaea within the order Methanomicrobiales. These are obligate anaerobic, methanogenic microorganisms that are capable of producing methane as a metabolic byproduct. They are commonly found in environments such as wetlands, digestive tracts of animals, and sewage sludge. The cells are typically irregularly shaped cocci or rods. Methanomicrobiaceae species utilize hydrogen or formate as electron donors and carbon dioxide as an electron acceptor to reduce methane. Some members of this family can also use secondary alcohols, such as methanol and ethanol, as substrates for methanogenesis.

Salicylanilides are a group of synthetic compounds that contain a salicylic acid moiety (a phenolic ring with a hydroxyl and a carboxyl group) linked to an aniline part through a carbon chain. They are known for their antimicrobial, antifungal, and anti-inflammatory properties. Some common representatives of this class include salicylanilide, 2-naphthoxyacetic acid methyl ester, and 3-amino-5-chlorosalicylanilide. These compounds have been used in various medical and veterinary applications, such as topical antimicrobial agents, ovicides (agents that kill the eggs of parasites), and anthelmintics (agents that expel or destroy parasitic worms). However, due to concerns about potential toxicity and environmental persistence, their use has been limited in recent years.

I'm sorry for any confusion, but "Methanocaldococcus" is not a medical term. It is a genus of methanogenic archaea that are capable of producing methane at relatively high temperatures, typically above 65 degrees Celsius. These organisms are often found in hydrothermal vents and other extreme environments. They are not directly related to human health or medicine.

Serine-tRNA ligase is an enzyme that plays a crucial role in protein synthesis, specifically in the attachment of the amino acid serine to its corresponding transfer RNA (tRNA) molecule. This enzyme catalyzes the formation of a ester bond between the carboxyl group of L-serine and the 3'-hydroxyl group of the tRNASerine, creating a charged tRNASerine molecule that can participate in protein synthesis on the ribosome.

The systematic name for this enzyme is L-serine:tRNA(Ser) ligase (AMP-forming), and it belongs to the family of ligases, specifically the transfer RNA ligases, which form aminoacyl-tRNA and related compounds. This enzyme is essential for maintaining the accuracy and fidelity of protein synthesis, as it ensures that the correct amino acid is attached to its corresponding tRNA molecule before being translated into a polypeptide chain on the ribosome.

A bioreactor is a device or system that supports and controls the conditions necessary for biological organisms, cells, or tissues to grow and perform their specific functions. It provides a controlled environment with appropriate temperature, pH, nutrients, and other factors required for the desired biological process to occur. Bioreactors are widely used in various fields such as biotechnology, pharmaceuticals, agriculture, and environmental science for applications like production of therapeutic proteins, vaccines, biofuels, enzymes, and wastewater treatment.

Sequence homology, amino acid, refers to the similarity in the order of amino acids in a protein or a portion of a protein between two or more species. This similarity can be used to infer evolutionary relationships and functional similarities between proteins. The higher the degree of sequence homology, the more likely it is that the proteins are related and have similar functions. Sequence homology can be determined through various methods such as pairwise alignment or multiple sequence alignment, which compare the sequences and calculate a score based on the number and type of matching amino acids.

... grow in colonies. The amino acid pyrrolysine was first discovered in a Methanosarcina species, M. barkeri. ... G. D. Sprott; C. J. Dicaire; G. B. Patel (1994). "The ether lipids of Methanosarcina mazei and other Methanosarcina species, ... Methanosarcina Genome Projects (from Genomes OnLine Database) Methanosarcina at BacDive - the Bacterial Diversity Metadatabase ... Methanosarcina from The Microbial Biorealm at Kenyon College Comparative Analysis of Methanosarcina Genomes (at DOE's IMG ...
"154 a newly identified regulator of nitrogen fixation in Methanosarcina mazei strain Gö1". RNA Biology. 14 (11): 1544-1558. doi ... identified together with 248 other sRNA candidates by RNA sequencing in methanogenic archaeon Methanosarcina mazei Gö1. These ... "Deep sequencing analysis of the Methanosarcina mazei Gö1 transcriptome in response to nitrogen availability". Proceedings of ... "41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1". Molecular Microbiology. 107 (5): 595 ...
Methanosarcina Regina Saum et al.: The F1FO ATP synthase genes in Methanosarcina acetivorans are dispensable for growth and ATP ... Methanosarcina acetivorans is a versatile methane producing microbe which is found in such diverse environments as oil wells, ... November 2006). "An unconventional pathway for reduction of CO2 to methane in CO-grown Methanosarcina acetivornas revealed by ... Only M. acetivorans and microbes in the genus Methanosarcina use all three known metabolic pathways for methanogenesis. ...
Mladenovska, Z.; Ahring, B. K. (1997). "Mixotrophic growth of two thermophilic Methanosarcina strains, Methanosarcina ... Type strain of Methanosarcina thermophila at BacDive - the Bacterial Diversity Metadatabase v t e (Articles with short ... Methanosarcina thermophila is a thermophilic, acetotrophic, methane-producing archaeon. Zinder, S. H.; Sowers, K. R.; Ferry, J ... Proctor LM; Lai R; Gunsalus RP (June 1997). "The methanogenic archaeon Methanosarcina thermophila TM-1 possesses a high- ...
... is the most fundamental species of the genus Methanosarcina, and their properties apply generally to the ... Methanosarcina barkeri can also be found in sewage, landfills, and in other freshwater systems. Morphology of Methanosarcina ... Maeder, Dennis; Anderson, Iian (November 2006). "The Methanosarcina barkeri Genome: Comparative Analysis with Methanosarcina ... Methanosarcina could produce positive Gram stain, but generally, it is Gram variable. M. barkeri has a thick cell wall ...
In enzymology, a Methanosarcina-phenazine hydrogenase (EC 1.12.98.3) is an enzyme that catalyzes the chemical reaction H2 + 2-( ... and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina ...
These are listed below: Methanosarcina horonobensis Methanoculleus horonobensis Methanoculleus horonobensis genome sequences ... "Methanosarcina horonobensis sp. nov., a methanogenic archaeon isolated from a deep subsurface Miocene formation". International ...
Methanosarcina barkeri Fusaro and Methanosarcina acetivorans C2A". Archaea. 2012: 1-10. doi:10.1155/2012/873589. PMC 3361143. ... and concanavalin A binding proteins of Methanosarcina acetivorans and Methanosarcina mazei". J Proteome Res. 8 (4): 1972-82. ... The genomes of all Methanosarcina species examined thus far have 4-10 paralogous DUF1608 containing proteins. The major and ... 7 (2-3): 293-9. doi:10.1016/S0723-2020(86)80022-4. Sowers KR, Boone JE, Gunsalus RP (1993). "Disaggregation of Methanosarcina ...
Sauer K, Thauer RK (October 1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and ... Sauer K, Harms U, Thauer RK (February 1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, ... Sauer K, Thauer RK (May 1999). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the ... LeClerc GM, Grahame DA (August 1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. ...
LeClerc GM, Grahame DA (August 1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. ... coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". ... coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina ...
Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of ...
Methanogenic genera Methanosarcina are common in marsh environments. They are both known to stimulate methane production in ...
Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of ...
Some archaea such as Methanosarcina acetivorans also fix nitrogen,. and several other methanogenic taxa, are significant ... "A CRISPRi-dCas9 System for Archaea and Its Use To Examine Gene Function during Nitrogen Fixation by Methanosarcina acetivorans ...
Ogawa T, Yoshimura T, Hemmi H (February 2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role ... diphosphate The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine. ...
Kandler O, Hippe H (May 1977). "Lack of peptidoglycan in the cell walls of Methanosarcina barkeri". Archives of Microbiology. ...
Methanosarcina acetivorans is known to have five types of subunits. The ancestor to eukarotic TriC is thought to have two. ...
2004 Methanosalsum Boone & Baker 2002 Methanosarcina Kluyver & van Niel 1936 ?"Candidatus Methanovorans" Chadwick et al. 2022 ( ...
High-resolution structures of an archaeal S-layer protein (MA0829 from Methanosarcina acetivorans C2A) of the Methanosarcinales ... "Structure of the surface layer of the methanogenic archaean Methanosarcina acetivorans". Proc Natl Acad Sci U S A. 109 (29): ...
... from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079 (3): 293-302. doi:10.1016/0167-4838(91)90072-8. PMID 1911853. Ma K, ... 10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri". J. Bacteriol. 172 (2): 564-71. doi:10.1128/jb. ...
Kandler, O.; Hippe, H. (1977). "Lack of peptidoglycan in the cell walls of Methano-sarcina barkeri" (PDF). Archives of ... Kandler, Otto; Hippe, Hans (January 1977). "Lack of peptidoglycan in the cell walls of Methano¬sarcina barkeri". Archives of ... In October 1976 Kandler discovered that two strains of the methanogen Methanosarcina barkeri did not contain peptidoglycan. ...
"Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains". Journal of Virology. 91 (22). ... Two archaeal viruses first described in 2017 are Metallosphaera turreted icosahedral virus and Methanosarcina spherical virus. ...
Formyl-MFR dehydrogenase was also isolated from Methanosarcina barkeri and Archaeoglobus fulgidus cell extracts. Molybdenum- ... "The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor". European Journal of ...
... boonei Methanosaeta concilii Methanosaeta thermophila Methanosarcina acetivorans Methanosarcina barkeri Methanosarcina mazei ... However, Methanosarcina barkeri is exceptional in possessing a superoxide dismutase (SOD) enzyme, and may survive longer than ... from Methanosarcina barkeri". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1079 (3): 293- ... Well-studied organisms that produce methane via H2/CO2 methanogenesis include Methanosarcina barkeri, Methanobacterium ...
5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". Journal of Bacteriology. 160 (2): 629-35. doi: ...
"Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase". Journal of Bacteriology. 187 ...
It is also present in some anaerobic microorganisms, such as Methanosarcina barkeri. Catalase is also universal among plants ... dismutase genes are transcriptionally up-regulated upon oxidative stress in the strictly anaerobic archaeon Methanosarcina ...
... coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". ... 5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro". European Journal of Biochemistry. 253 ( ...
A second type of archaeal cell wall is found in Methanosarcina and Halococcus. This type of cell wall is composed entirely of a ...
November 2006). "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina ... July 2002). "The genome of Methanosarcina mazei: evidence for lateral gene transfer between bacteria and archaea". Journal of ...
Methanosarcina grow in colonies. The amino acid pyrrolysine was first discovered in a Methanosarcina species, M. barkeri. ... G. D. Sprott; C. J. Dicaire; G. B. Patel (1994). "The ether lipids of Methanosarcina mazei and other Methanosarcina species, ... Methanosarcina Genome Projects (from Genomes OnLine Database) Methanosarcina at BacDive - the Bacterial Diversity Metadatabase ... Methanosarcina from The Microbial Biorealm at Kenyon College Comparative Analysis of Methanosarcina Genomes (at DOEs IMG ...
"Methanosarcina barkeri" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Methanosarcina barkeri" by people in UAMS Profiles by year, ... Below are the most recent publications written about "Methanosarcina barkeri" by people in Profiles over the past ten years. ... Below are MeSH descriptors whose meaning is more general than "Methanosarcina barkeri". ...
Methanosarcina acetivorans C2A). Find diseases associated with this biological target and compounds tested against it in ...
Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A ... Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A ...
Methanosarcina acetivorans, with a genome size of ~5.7 mb, is the largest sequenced archaeon methanogen and unique amongst the ... Maeder DL, et al., et al.: The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and ... Lessner D, et al., et al.: ... of CO2 to methane in CO-grown Methanosarcina acetivorans revealed by proteomics. Proceedings of ... Li L, et al., et al.: ... and Microarray Analysis of the Archaeon Methanosarcina Acetivorans Grown with Acetate ... Journal of ...
The reduction of environmentally abundant iron oxides by the methanogen Methanosarcina barkeri. In: Frontiers in Microbiology. ... The reduction of environmentally abundant iron oxides by the methanogen Methanosarcina barkeri. Frontiers in Microbiology. 2023 ... The reduction of environmentally abundant iron oxides by the methanogen Methanosarcina barkeri. / Eliani-Russak, Efrat; Tik, ... Here we tested the capability of the methanogenic archaeon Methanosarcina barkeri to reduce three naturally abundant iron ...
ulilysin (Methanosarcina acetivorans). M43.007. Yes. Mername-AA293 peptidase. M43.008. -. mirolysin (Tannerella forsythia). ...
AM4 CODH; Dv CODH, Desulfovibrio vulgaris CODH; Ch CODH-IV, C. hydrogenoformans CODH-IV; Mb CODH, Methanosarcina barkeri CODH; ... It is noted that Methanosarcina barkeri CODH (Mb CODH), which is branched between Ch CODH-V and Dv CODH in the phylogenetic ... Structure of the α2ε2 Ni-dependent CO dehydrogenase component of the Methanosarcina barkeri acetyl-CoA decarbonylase/synthase ...
Methanosarcina, 36.7%). Further archaeal sequences were assigned to the class Methanobacteria. These sequences were assigned to ... and Methanocorpusculum and Methanosarcina (both Methanomicrobia), also represented different methanogens which differed in ... the genera Methanosphaera (class Methanobacteria) and Methanocorpusculum (class Methanomicrobia) and Methanosarcina (class ...
In this study we performed comparative transcriptomics on the methanogen Methanosarcina barkeri, which was incubated at 30ËšC ... In this study we performed comparative transcriptomics on the methanogen Methanosarcina barkeri, which was incubated at 30ËšC ... In this study we performed comparative transcriptomics on the methanogen Methanosarcina barkeri, which was incubated at 30ËšC ... In this study we performed comparative transcriptomics on the methanogen Methanosarcina barkeri, which was incubated at 30ËšC ...
Heimann, A.C.; Batstone, D.J.; Jakobsen, R. Methanosarcina spp. drive vinyl chloride dechlorination via interspecies hydrogen ... producing H2 from acetate in the case of Methanosarcina [36]. ...
... methanosarcina barkeri, in anaerobic mesophilic granular sludge by fluorescent in situ hybridization and confocal laser ... The MB4 probe specifically detected Methanosarcina barkeri, and the MB3 probe detected the presence of all mesophilic ... Differentiation of Methanosaeta concilii, methanosarcina barkeri, in anaerobic mesophilic granular sludge by fluorescent in ... Differentiation of Methanosaeta concilii, methanosarcina barkeri, in anaerobic mesophilic granular sludge by fluorescent in ...
The Methanosarcina mazei casposase is a site-specific integrase. The casposase from A. boonei, a species of archaea from the ... Methanosarcina mazei casposon organization and initial biochemical characterization.. (A) (left) Schematic of a representative ... We show here that the Methanosarcina mazei casposase can integrate varied forms of the casposon end in vitro, and recapitulates ... The authors purify a casposases from Methanosarcina mazei and determine sequence requirements for integration. The authors ...
Krzycki, J.A. and Zeikus, J.G. (1984). Characterization and purification of carbon monoxide dehydrogenase from Methanosarcina ... Grahame, D.A. and Stadtman, T.C. (1987). Carbon monoxide dehydrogenase from Methanosarcina barkeri. Disaggregation, ... Structure of the alpha2epsilon2 Ni-dependent CO dehydrogenase component of the Methanosarcina barkeri acetyl-CoA decarbonylase/ ...
Deconstructing Methanosarcina acetivorans into an acetogenic archaeon. Proc. Natl. Acad. Sci. U.S.A. 119 (2), e2113853119. full ...
Deconstructing Methanosarcina acetivorans into an acetogenic archaeon. 2022. Proceedings of the National Academy of Sciences of ...
Methanosarcina) in the oceans, which spewed prodigious amounts of methane into the atmosphere,... ... Genetic evidence shows a change in Methanosarcina at that time, allowing it to become a major producer of methane from an ... Genomic analysis revealed that Methanosarcina had acquired a particularly fast means of making methane via gene transfer from ... Second, we show that the efficient acetoclastic pathway in Methanosarcina emerged at a time statistically indistinguishable ...
LysargiNase is a metalloproteinase found in the thermophilic archaea Methanosarcina acetivorans. It specifically cleaves before ...
Methanosarcina thermophila [gbbct]: 21 CDSs (6336 codons) fields: [triplet] [frequency: per thousand] ([number]) UUU 15.6( 99 ...
Archeae Methanosarcina acetivorans. 2.3±0.2μm grown on methanol: 1.8±0.2μm grown on acetate. μm. 106688. Hildenbrand C, Stock T ...
gi,21226142,ref,NP_632064.1, Glycine betaine transporter, ATP-binding protein [Methanosarcina mazei Goe1] gi,19224202.... ... gi,23052070,ref,ZP_00078752.1, COG1122: ABC-type cobalt transport system, ATPase component [Methanosarcina barkeri]. ...
Species Methanosarcina thermophila [TaxId:2210] [110718] (3 PDB entries). Uniprot P38503. *. Domain d2af3c_: 2af3 C: [126654]. ... PDB Description: phosphotransacetylase from methanosarcina thermophila soaked with coenzyme a. PDB Compounds: (C:) Phosphate ... d2af3c_ c.77.1.5 (C:) Phosphotransacetylase Pta {Methanosarcina thermophila [TaxId: 2210]} ...
4-1), Methanosarcina and Methanothrix play an important role in completion of anaerobic digestion and in accumulating H2, which ... MR- encoding genes have been cloned and sequenced from Methanococcus vanielli, M. voltae, Methanosarcina barkeri, ... such as Methanosarcina spp. and Methanothrix spp. (now, Methanosaeta), which are incapable of using formate. Since a large ...
D. J. Lessner, L. Li, Q. Li et al., "An unconventional pathway for reduction of CO2 to methane in CO-grown Methanosarcina ... S. Bäumer, T. Ide, C. Jacobi, A. Johann, G. Gottschalk, and U. Deppenmeier, "The F420H2 dehydrogenase from Methanosarcina mazei ... M. Rother and W. W. Metcalf, "Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: an unusual way of life for ... C. Welte and U. Deppenmeier, "Re-evaluation of the function of the F420 dehydrogenase in electron transport of Methanosarcina ...
Methanosarcina barkeri 62% * Novo Nordisk Fonden - MICROBIAL CHEMICAL PLANTS: harnessing microbial metabolism for the ...
A timely combination of two factors may have sent Methanosarcina into overdrive, according to the findings reported in the ... The chief perpetrators were a microscopic methane-producing archaea life-form called Methanosarcina that bloomed explosively in ...
... with high methane concentrations were dominated by sequences affiliated rather to the methylotrophic genera Methanosarcina and ...
Genome sequence of Methanosarcina soligelidi SMA-21, isolated from Siberian permafrostaffected soil. Mashal Alawi, Nicole ...
  • The amino acid pyrrolysine was first discovered in a Methanosarcina species, M. barkeri. (wikipedia.org)
  • Methanosarcina barkeri" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Methanosarcina barkeri" by people in UAMS Profiles by year, and whether "Methanosarcina barkeri" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Methanosarcina barkeri" by people in Profiles over the past ten years. (uams.edu)
  • Feist and coworkers first developed a genome-scale model (named i AF692) [ 11 ] for the fresh-water methanogen, Methanosarcina barkeri using a draft version of its genome. (biomedcentral.com)
  • Here we tested the capability of the methanogenic archaeon Methanosarcina barkeri to reduce three naturally abundant iron oxides in the methanogenic zone: the low-reactive iron minerals hematite and magnetite, and the high-reactive amorphous iron oxide. (iucc.ac.il)
  • In this study we performed comparative transcriptomics on the methanogen Methanosarcina barkeri, which was incubated at 30ËšC and 0ËšC with 10-20 mM calcium-, magnesium-, or sodium perchlorate. (princeton.edu)
  • Oligonucleotide probes, designed from genes coding for 16S rRNA, were developed to differentiate Methanosaeta concilii, Methanosarcina barkeri, and mesophilic methanogens. (canada.ca)
  • All M. concilii oligonucleotide probes (designated MS1, MS2, and MS5) hybridized specifically with the target DNA, but MS5 was the most specific M. concilii oligonucleotide probe.Methanosarcina barkeri oligonucleotide probes (designated MB1, MB3, and MB4) hybridized with different Methanosarcinaspecies. (canada.ca)
  • The MB4 probe specifically detected Methanosarcina barkeri, and the MB3 probe detected the presence of all mesophilic Methanosarcina species. (canada.ca)
  • These new oligonucleotide probes facilitated the identification, localization, and quantification of the specific relative abundance of M. concilii and Methanosarcina barkeri, which play important roles in methanogenesis. (canada.ca)
  • This enzyme, characterized from the methanogenic archaeon Methanosarcina barkeri, reduces cobalt(II) back to cobalt(I), restoring activity. (expasy.org)
  • The enzyme from Methanosarcina barkeri contains a C-terminal [4Fe-4S] ferredoxin-like domain. (expasy.org)
  • Methanosarcina acetivorans , with a genome size of ~5.7 mb, is the largest sequenced archaeon methanogen and unique amongst the methanogens in its biochemical characteristics. (biomedcentral.com)
  • LysargiNase is a metalloproteinase found in the thermophilic archaea Methanosarcina acetivorans. (sigmaaldrich.com)
  • We show here that the Methanosarcina mazei casposase can integrate varied forms of the casposon end in vitro, and recapitulates several properties of CRISPR-Cas integrases including site-specificity. (elifesciences.org)
  • Methanosarcina mazei casposon organization and initial biochemical characterization. (elifesciences.org)
  • Three for two: By using a Methanosarcina mazei PylRS triple mutant (Y306G, Y384F, I405R) the incorporation of two new exo-norbornene-containing pyrrolysine analogues was achieved. (cipsm.de)
  • Taxonomy and halotolerance of mesophilic Methanosarcina strains, assignment of strains to species, and synonymy of Methanosarcina mazei and Methanosarcina frisia . (riken.jp)
  • General Information: Methanosarcina mazei Go1 (DSM 3647) was isolated from an anaerobic sewage digester in Germany. (up.ac.za)
  • Methanosarcina is a genus of euryarchaeote archaea that produce methane. (wikipedia.org)
  • Methanosarcina may be the only known anaerobic methanogens that produce methane using all three known metabolic pathways for methanogenesis. (wikipedia.org)
  • Researchers at MIT are proposing that the end-Permian extinction-the period some 252 million years ago when about 90% of all species on Earth were suddenly wiped out-may have been instigated by an explosive bloom of methane-producing archea ( Methanosarcina ) in the oceans, which spewed prodigious amounts of methane into the atmosphere, disrupting the carbon cycle and devastatingly changing the climate and chemistry of the oceans. (greencarcongress.com)
  • Genetic evidence shows a change in Methanosarcina at that time, allowing it to become a major producer of methane from an accumulation of organic carbon in the water. (greencarcongress.com)
  • Genomic analysis revealed that Methanosarcina had acquired a particularly fast means of making methane via gene transfer from another microbe. (greencarcongress.com)
  • Species of Methanosarcina are also noted for unusually large genomes. (wikipedia.org)
  • In addition to these two pathways, species of Methanosarcina can also metabolize methylated one-carbon compounds through methylotrophic methanogenesis. (wikipedia.org)
  • Only Methanosarcina species possess all three known pathways for methanogenesis, and are capable of utilizing no less than nine methanogenic substrates, including acetate. (wikipedia.org)
  • With this reduction activity involved, it is hard to image why DIET is still necessary for the living of Geobacter and if acetate is released by Geobacter during ferric iron reduction, DIET would be also unnecessary for the living of Methanosarcina. (peerj.com)
  • Methanosarcina strains were grown in single-cell morphology (Sowers et al. (wikipedia.org)
  • Methanosarcina are the world's most diverse methanogens in terms of ecology. (wikipedia.org)
  • Second, we show that the efficient acetoclastic pathway in Methanosarcina emerged at a time statistically indistinguishable from the extinction. (greencarcongress.com)
  • According to a theory published in 2014, Methanosarcina may have been largely responsible for the largest extinction event in the Earth's history, the Permian-Triassic extinction event. (wikipedia.org)
  • Methanosarcina grow in colonies and show primitive cellular differentiation. (wikipedia.org)
  • Methanosarcina cell membranes are made of relatively short lipids, primarily of C25 hydrocarbons and C20 ethers. (wikipedia.org)
  • Methanosarcina have also been found in the human digestive tract. (wikipedia.org)
  • A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. (nih.gov)
  • Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila. (expasy.org)
  • Nomenclature follows the description for Methanosarcina thermophila. (nih.gov)
  • and BS induced selective raise of Methanosarcina thermophila. (unipd.it)
  • Methanosarcina may be the only known anaerobic methanogens that produce methane using all three known metabolic pathways for methanogenesis. (wikipedia.org)
  • In addition to these two pathways, species of Methanosarcina can also metabolize methylated one-carbon compounds through methylotrophic methanogenesis. (wikipedia.org)
  • Only Methanosarcina species possess all three known pathways for methanogenesis, and are capable of utilizing no less than nine methanogenic substrates, including acetate. (wikipedia.org)
  • Growth and methanogenesis by Methanosarcina strain 227 on acetate and methanol. (microbiologyresearch.org)
  • Species in the genus Methanosarcina are ideally suited for investigating principles of archaeal transcription through analysis of the capacity to utilize a diversity of substrates for growth and methanogenesis. (psu.edu)
  • Identification of methyl coenzyme M as an intermediate in methanogenesis from acetate in Methanosarcina spp. (umass.edu)
  • The results presented here establish that MreA participates in the global regulation of diverse methanogenic pathways in the genus Methanosarcina. (psu.edu)
  • from methanol-grown cells of Methanosarcina barkeri is not a flavoenzyme. (srcsignaling.com)
  • Influence of sulphur-containing compounds on the growth of Methanosarcina barkeri in a defined medium. (microbiologyresearch.org)
  • Methanosarcina strains were grown in single-cell morphology (Sowers et al. (wikipedia.org)