Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)Narcotics: Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.Opiate Substitution Treatment: Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.Opioid-Related Disorders: Disorders related or resulting from abuse or mis-use of opioids.Heroin Dependence: Strong dependence, both physiological and emotional, upon heroin.Methadyl Acetate: A narcotic analgesic with a long onset and duration of action.Buprenorphine: A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Neonatal Abstinence Syndrome: Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.Heroin: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.PyrrolidinesDrug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Dextropropoxyphene: A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.Substance Abuse, Intravenous: Abuse, overuse, or misuse of a substance by its injection into a vein.Narcotic Antagonists: Agents inhibiting the effect of narcotics on the central nervous system.Street Drugs: Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.Substance-Related Disorders: Disorders related to substance abuse.Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Opium: The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.Oxidoreductases, N-DemethylatingStereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Therapeutic Community: Psychotherapeutic technique which emphasizes socioenvironmental and interpersonal influences in the resocialization and rehabilitation of the patient. The setting is usually a hospital unit or ward in which professional and nonprofessional staff interact with the patients.Directly Observed Therapy: A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.PrisonersDose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

*  Methadone Question - Addiction: Substance Abuse - MedHelp

I have been sober off of pain meds and heroin for almost 6 months and for about 5 months I have been on Methadone Maintenance. ... Methadone Question. I have been sober off of pain meds and heroin for almost 6 months and for about 5 months I have been on ... I was on Methadone Maintenance for 7 years at doses reaching in the hundreds and hundreds of milligrams a day. I just found ... I was on Methadone Maintenance for 7 years at doses reaching in the hundreds and hundreds of milligrams a day. I just found ...
medhelp.org/posts/Addiction-Substance-Abuse/Methadone-Question/show/1270448

*  Methadone and Hydrocodone - Addiction: Substance Abuse - MedHelp

I have started taking Methadone on occasion. This morning I took a 10mg Methadone and this evening I took 3 10mg Hydrocodones ... Once you become addicted to the methadone, it is a lot harder to kick that habit. The methadone wd's last about 3 weeks for ... Once you become addicted to the methadone, it is a lot harder to kick that habit. The methadone wd's last about 3 weeks for ... I have started taking Methadone on occasion. This morning I took a 10mg Methadone and this evening I took 3 10mg Hydrocodones. ...
medhelp.org/posts/Addiction-Substance-Abuse/Methadone-and-Hydrocodone/show/579587

*  Methadone (Oral Route) Proper Use - Mayo Clinic

Methadone can cause serious unwanted effects if taken by adults who are not used to strong narcotic pain medicines, children, ...
mayoclinic.org/drugs-supplements/methadone-oral-route/proper-use/drg-20075806

*  methadone vs zopicone 7.5 - Methadone Community - MedHelp

... doctor wont do no more 4 weeks detox so they said when i go into clinic in 2 weeks they will put my methadone up, probley 80- ... will a higher dosage of methadone help me and take less zopicone at night ? ...
medhelp.org/posts/Methadone-Community/methadone-vs-zopicone-75/show/1935548

*  DailyMed - DOLOPHINE- methadone hydrochloride tablet

Use a conversion ratio of 1:2 mg for parenteral to oral methadone (e.g., 5 mg parenteral methadone to 10 mg oral methadone). ... Methadone disposition was not substantially altered [see Drug Interactions (7)]. Zidovudine:Methadone increased the AUC of ... The effects of methadone on the QT interval have been confirmed in in vivo laboratory studies, and methadone has been shown to ... Methadone is a lipophilic drug and the steady-state volume of distribution ranges between 1.0 to 8.0 L/kg. In plasma, methadone ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7a4840d6-98e3-4523-81a0-ef0b3a47d0c2

*  Methadone - Lycos.com

Check your spelling. Maybe you accidentally invented a new word?. Try using fewer keywords, or general terms.. ...
search.lycos.com/web/?q=Methadone

*  About benzos and methadone - Addiction: Substance Abuse - MedHelp

Hi, it might be the methadone. I take it and I've noticed that I can hardly remember anything. I've taken methadone over 7yrs ... Hi, it might be the methadone. I take it and I've noticed that I can hardly remember anything. I've taken methadone over 7yrs ... About benzos and methadone. Do any form of benzos like xanax, if you have taking it for awhile can it give you short term ... If it is the benzos and not the methadone(im at 20 mgs), then when i get off the xanax will i get my memory back???? ...
medhelp.org/posts/Addiction-Substance-Abuse/About-benzos-and-methadone/show/1703705

*  DailyMed - METHADONE HYDROCHLORIDE- methadone hydrochloride powder

Methadone Hydrochloride contains methadone, an opioid agonist and a Schedule II controlled substance. Methadone can be abused ... METHADONE HYDROCHLORIDE (UNII: 229809935B) (METHADONE - UNII:UC6VBE7V1Z). METHADONE HYDROCHLORIDE. 1 g in 1 g. ... METHADONE HYDROCHLORIDE- methadone hydrochloride powder To receive this label RSS feed. Copy the URL below and paste it into ... The effects of methadone on the QT interval have been confirmed in in vivo laboratory studies, and methadone has been shown to ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2C560DBA-8B7E-4BA1-A390-30FFF6AF8AEB

*  Prescribing heroin is more 'cost-effective' than methadone, claim scientists | Daily Mail Online

Patients treated with the prescribed heroin were more likely to stay in treatment than those prescribed methadone, according to ... Those in the methadone therapy group generated an average lifetime societal cost of £730,000 ($1.14 million) per person, while ... Prescribing drug users heroin is more 'cost-effective' than methadone, claim scientists. * Users prescribed medicated heroin ... Those in the heroin group were also more likely to live longer than someone receiving methadone maintenance therapy.. ...
dailymail.co.uk/health/article-2114302/Prescribing-heroin-cost-effective-methadone-claim-scientists.html

*  NIDA Notes Articles: Methadone | National Institute on Drug Abuse (NIDA)

Crime Does Not Increase Around Methadone Clinics in Baltimore. January 2013. Methadone treatment centers are not foci for ... Intervention Improves Employment Outlook For Methadone Patients. June 2008. Describes a study of unemployed methadone patients ... Interim Methadone Raises Odds of Enrolling in Comprehensive Treatment. April 2007. Reports on a study to investigate the use of ... Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues. December 2009. Describes findings of a study revealing that ...
https://drugabuse.gov/news-events/nida-notes/articles/term/138/methadone/title?combine=

*  Overview Of Methadone East Northport NY - East Northport NY, overview of methadone, East Northport NY methadone metabolism,...

Methadone is an opioid. Methadone is synthetic by nature. Methadone is also an analgesic. Methadone is basically recommended for the chronic drug abusers. Methadone has been found to be an ideal medication for the treatment of addiction from narcotic substances.
guides.wkbw.com/Overview_Of_Methadone_East_Northport_NY-r989527-East_Northport_NY.html

*  Overview Of Methadone Fredonia NY - Fredonia NY, overview of methadone, Fredonia NY methadone metabolism, Fredonia NY ...

Methadone is an opioid. Methadone is synthetic by nature. Methadone is also an analgesic. Methadone is basically recommended for the chronic drug abusers. Methadone has been found to be an ideal medication for the treatment of addiction from narcotic substances.
guides.wkbw.com/Overview_Of_Methadone_Fredonia_NY-r989527-Fredonia_NY.html

*  What works in drug addiction? | BJPsych Advances

Clonidine and lofexidine are α2-adrenoreceptor agonists that reduce somatic symptoms of opioid withdrawal. Opioid detoxification with these agents can be achieved in 5-7 days. However, neither agent can suppress symptoms such as craving, lethargy, insomnia, restlessness and muscle aches. Adverse effects include sedation and hypotension, although these are less common with lofexidine.. A systematic Cochrane review of 10 studies comparing α2-agonists and methadone detoxification over 10 days found no difference in efficacy, although more clients remained in contact with treatment services following methadone detoxification (Gowing et al, 2002).Kleber et al(1985) reported a trial of 49 methadone maintenance patients randomised to out-patient detoxification with clonidine or reducing doses of methadone over 30 days. Forty per cent completed the detoxification process, of whom one-third were abstinent at 6-month follow-up. An equivalent ...
apt.rcpsych.org/content/9/4/280.full

*  Methadone (an opioid drug) for treating people with cancer pain | Cochrane

Bottom line Methadone taken by mouth provided good pain relief for most adults with moderate or severe cancer pain.. Background One person in two or three who gets cancer will suffer from pain that becomes moderate or severe in intensity. The pain tends to get worse as the cancer progresses. Methadone has been used for many years as one of a number of different pain killers for cancer pain.. Study characteristics In this updated review we set out to estimate how well methadone worked, how many people had side effects, and how severe those side effects were - for example, whether they were so severe that participants stopped taking their methadone.. In May 2016, we found just six studies with 388 adult participants. The studies were often small, and compared different preparations.. Key findings For pain relief there did not seem to be much difference between methadone and morphine. For most people pain was reduced from ...
cochrane.org/CD003971/SYMPT_methadone-opioid-drug-treating-people-cancer-pain

*  Warren ready to vote on new methadone ordinance - Maine news, sports, obituaries, weather - Bangor Daily News

WARREN, Maine - Warren Selectmen voted Wednesday night to have a special town meeting at 7 p.m. Tuesday, Aug. 2, to decide if the town should create a new ordinance regulating where methadone clinics, large professional offices and medical facilities can set up shop within the town's lines.. The town will also vote on whether to raise $30,000 for anticipated legal fees.. A methadone clinic company is currently suing the town after it set up a moratorium on methadone clinics while officials worked out an ordinance to regulate them. The town is fighting the lawsuit.. The meeting will be at the Masonic Hall at 105 Camden Road in Warren.. ...
bangordailynews.com/2011/07/21/news/midcoast/warren-ready-to-vote-on-new-methadone-ordinance/print/

*  Merchants and city councilwoman call for closing methadone clinic in Hampden - Chicago Tribune

A two-year-old methadone clinic off the Avenue in Hampden is under fire from a Baltimore City councilwoman and merchants, who say it should be shut down because of drug dealing, loitering and other nuisances that are endangering thousands of children at schools and recreation centers in the immediate area.
chicagotribune.com/ph-ms-methadone-clinic-0822-20130815-story.html

*  Judge Allows Methadone Clinic in Shopping Center | WEKU

City leaders misinterpreted Covingtons zoning code when they decided NKY Med LLC had to obtain a zoning exemption to open a methadone clinic in the Latonia
weku.fm/post/judge-allows-methadone-clinic-shopping-center

*  DMOZ - Health: Addictions: Substance Abuse: Methadone Maintenance

Methadone Maintenance is the most tested and proven way to cure opiate/heroin addiction. It has been used for 30 years, yet people do not see it as medicine but trading one addiction for another. No other medication has such stigma attached to it. But it still has the highest success rate in treating addiction.
dmoztools.net/Health/Addictions/Substance_Abuse/Methadone_Maintenance/

*  Methadone safeguards

My sympathy goes out to the family of Mark Bishop for their loss due to an auto accident Feb. 18 in Connoquenessing Township. Could the accident have been avoided? Yes. First, however, let me make a point. In 1969, I lived in Newburgh, N.Y. Newburgh was famous for three things: It was the model city of the United States, it had the widest main street in the country, and people had to go to the police station to pick up their welfare check. You guessed it. If you had booze on your breath or had any doings with the police, no matter how small, or didn't have proper identification, no check. My point is, people are getting methadone at clinics and driving away. They are there because they have had a drug problem in the past, and are not pillars of society to boot. Yet we, the taxpayers, pay for this plus, in many cases, mileage allowance, bus fare, or even cab fare for some people to get to and from the methadone clinics. I did not cause their drug addiction; I shouldn't have ...
butlereagle.com/article/20130309/EDITORIAL02/130309710/0/SPORTS0102&Template=printart

*  Methadone Versus Placebo in Spine Fusion - Full Text View - ClinicalTrials.gov

What is the influence of methadone on postoperative analgesia after lumbar interbody fusion in opioid naïve patients or patients who are taking less than equivalent of 15 mg IV morphine each day? What is the incidence of opioid related postoperative side effects after the administration of methadone in the operating room ...
https://clinicaltrials.gov/ct2/show/NCT01125059

*  Take-home methadone concerns lawmakers - The Indianapolis Star - Discussion on Topix

My kid is an addict. I have been in the 45th street clinic a few times and have talked to the people there. I want to believe they want to do well, however, I wouldn't take my worst enemy there. They get these people hooked on methadone and then they just leave themn to rot. There are no set treatment plans, time lines, goals or follow up. I feel most of the counselors are in over their heads. My kid is so hooked on the methadone he can not do anything else. I don't feel there is any incentive to get better. Somebody wrote 'the clinic keeps me out of your garage', and I believe that is exactly what the clinic is for and not so much to get these people better. If the state is going to fund this program the clinic needs to be held accountable and held to the highest patient care standards, and the junkies need to be held accountable even more so ...
topix.com/forum/indy/TLCJCBITFM4BEDEQK

*  Grits for Breakfast: 2nd Gregg County death from Methadone withdrawal spurs calls for uniform policy on prescription drugs in...

I agree with you guys. I just got out of CFCF in Philadelphia, PA. They give methadone there if you are in a clinic for heroin or opiate withdrawal. I am prescribed 300mg. A day split in four doses thru the day from pain management, then take 30mg. Oxycodone tabs for breakthru pain. They would not give me anything. They said they don't give out that for pain, only for people who are at a clinic and were there before being locked up. I was transferred there from Bucks County prison, they give nothing either, not even methadone fir clinic patients. I was only down for 2 weeks. Inward horrible. And didn't seem lime it was even getting better. I think it was still getting worse. I feel so bad for my cellies, i was on that toilet more than ever been. If not shifting, then vomiting. Freezing, then hot, sweating, chills, crawling feeling on my skin, hard time breathing, rapid heartbeat, very high blood pressure. I was going thru it like never before. I thought oxycodone was hard ...
gritsforbreakfast.blogspot.com/2011/06/2nd-gregg-county-methadone-death-spurs.html

*  Mobile Psychosocial Interventions for MMT Clients - Full Text View - ClinicalTrials.gov

This study will develop and implement a mobile technology-delivered psychosocial intervention for opioid-dependent adults in methadone maintenance treatment (MMT). This novel therapeutic system promises to be cost-effective and to enable the provision of flexible, on-demand therapeutic support outside of the formal treatment setting. The specific aims of this investigation are as follows: Aim 1: The investigators will develop a novel, interactive, evidence-based psychosocial intervention delivered via mobile phones, designed to promote skills acquisition and reduce illicit drug use. Specifically, our Mobile Therapeutic System (MTS) will offer key elements of a psychosocial intervention for substance use disorders of known efficacy (the Community Reinforcement Approach). Participants will be provided with unlimited daily prompts to encourage use of the program and will be able to access the application at any time and as much as they choose, within their natural environments. Our iterative ...
https://clinicaltrials.gov/ct2/show/NCT01632982

*  FASTBALL - CHARLIE, THE METHADONE MAN LYRICS

Charlie, The Methadone Man lyrics - Living to get his freak on Sporting his leopard skin thong Charlie the Methadone Man Plays Sunday nights in a rock and roll band Charlie the...
lyricsty.com/fastball-charlie-the-methadone-man-lyrics.html

*  Medication adherence strategies for drug abusers with HIV/AIDS. | Base documentaire | BDSP

This paper describes two clinical techniques aiming to improve adherence to medications for HIV/AIDS in methadone maintenance patients. The first technique, providing on-site dispensing of antiretroviral medications, enhanced medication adherence but did not produce enduring effects beyond the time of the intervention. To develop a more long-...
bdsp.ehesp.fr/Base/168654/

*  Methadone Meltdown | Houston Press

There's not much seedier than the sight of the sun rising on a methadone clinic's early-morning trade. Everything about the scene screams shame, from...
houstonpress.com/news/methadone-meltdown-6586921

*  using percocet to withdrawal from methadone - Addiction: Substance Abuse - MedHelp

I'm on day 15 of using percocet 7.5 (4 and then 3 a day) to come off of 10 mg methadone per day (3 yrs). My question is, if i use this percocet will i then withdrawal from it? Heres the details: ...
medhelp.org/posts/Addiction-Substance-Abuse/using-percocet-to-withdrawal-from-methadone/show/1569966

*  methadone withdrawal length - MedHelp

Are the withdrawal symptoms I am suffering from the suboxone withdrawal or are they from the residual methadone withdrawal? I suspect that these symptoms are st...
healthquestions.medhelp.org/methadone-withdrawal-length

*  Methadone abuse, misuse on the rise as painkiller enters mainstream - tribunedigital-orlandosentinel

Methadone, once used mainly in addiction-treatment centers to replace heroin, is today being given out by family doctors, osteopaths and nurse practitioners for throbbing backs, joint injuries and a
articles.orlandosentinel.com/2008-08-17/news/methadone17_1_methadone-heroin-pain

*  Grandmother arrested in methadone death of 1-year-old granddaughter | GazetteXtra

The grandmother of a child who died of an apparent methadone overdose Dec. 26 in Janesville faces the same charge as the child's mother.
gazettextra.com/article/20140226/ARTICLES/140229787/1172

*  Methadone to blame for more than half UK toddler poisoning deaths - Burnley Express

The number of teens being poisoned over the past 20 years has risen sharply with more than half of toddler deaths from drug poisoning caused by methadone, researchers say.
burnleyexpress.net/news/methadone-to-blame-for-more-than-half-uk-toddler-poisoning-deaths-1-7917800

*  methadone

Calgary facility on move for third time since 2003 Lisa Jovetic isn't the kind of woman who often comes to mind when people grumble about drug addicts. The once happily married mother of two and self-described "goody-goody" got hooked on drugs nearly five years ago after she was hospitalized for pneumonia and contracted a superbug….. Continue reading ›. ...
treatmentcenters.com/tag/methadone/

Methadone clinic: A methadone clinic is a clinic which has been established for the dispensing of methadone (Dolophine), a schedule II opioid analgesic, to those who abuse heroin and other opioids. The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone.Uniform State Narcotic Drug Act: The National Conference of Commissioners on Uniform State Laws developed the Uniform State Narcotic Drug Act in 1934 due to the lack of restrictions in the Harrison Act of 1914. The act was a revenue-producing act and, while it provided penalties for violations, it did not give authority to the states to exercise police power regarding either seizure of drugs used in illicit trade or punishment of those responsible.Comfort Food (novel): Comfort Food: A Novel by Noah Ashenhurst contains a cast of characters: a romantic academic, a self-assured young writer, an enigmatic musician, a slacker, a wealthy mountaineer, and a former heroin addict—characters whose lives intersect in the unique, award-winning debut novel.NoracymethadolAgonist–antagonistOpioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.Neonatal withdrawalDrug test: A drug test is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers screening for drugs prohibited by law (such as cannabis, cocaine and heroin) and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC (blood alcohol content).PyrrolidineOpioid overdose: .0, -Morphia (disambiguation): Morphia, also called morphine, is a highly potent opiate analgesic drug.DextropropoxypheneList of drug interactions: The following is a list of interactions with various prescription and over-the counter drugs:Substance-related disorderBenzodiazepine withdrawal syndromeOpium lampSharpless asymmetric dihydroxylation: Sharpless asymmetric dihydroxylation (also called the Sharpless bishydroxylation) is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol.Palladia (social services organization): Palladia, Inc. is a social services organization in New York City, working with individuals and families challenged by addiction, homelessness, AIDS, domestic violence, poverty and trauma.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Stateville Penitentiary Malaria Study: The Stateville Penitentiary malaria study was a controlled study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois in the 1940s. The study was conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.CodeineLow-dose naltrexone: Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as multiple sclerosis. Naltrexone is typically prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist.

(1/993) Solid-phase microextraction for cannabinoids analysis in hair and its possible application to other drugs.

This paper describes the application of solid-phase microextraction (SPME) to cannabis testing in hair. Fifty milligrams of hair was washed with petroleum ether, hydrolyzed with NaOH, neutralized, deuterated internal standard was added and directly submitted to SPME. The SPME was analyzed by GC-MS. The limit of detection was 0.1 ng/mg for cannabinol (CBN) and delta9-tetrahydrocannabinol (THC) and 0.2 ng/mg for cannabidiol (CBD). THC was detected in a range spanning from 0.1 to 0.7 ng/mg. CBD concentrations ranged from 0.7 to 14.1 ng/mg, and CBN concentrations ranged from 0.4 to 0.7 ng/mg. The effectiveness of different decontamination procedures was also studied on passively contaminated hair. The proposed method is also suitable for the analysis of methadone in hair; cocaine and cocaethylene can be detected in hair with SPME extraction after enzymatic hydrolysis.  (+info)

(2/993) Safer sex strategies for women: the hierarchical model in methadone treatment clinics.

Women clients of a methadone maintenance treatment clinic were targeted for an intervention aimed to reduce unsafe sex. The hierarchical model was the basis of the single intervention session, tested among 63 volunteers. This model requires the educator to discuss and demonstrate a full range of barriers that women might use for protection, ranking these in the order of their known efficacy. The model stresses that no one should go without protection. Two objections, both untested, have been voiced against the model. One is that, because of its complexity, women will have difficulty comprehending the message. The second is that, by demonstrating alternative strategies to the male condom, the educator is offering women a way out from persisting with the male condom, so that instead they will use an easier, but less effective, method of protection. The present research aimed at testing both objections in a high-risk and disadvantaged group of women. By comparing before and after performance on a knowledge test, it was established that, at least among these women, the complex message was well understood. By comparing baseline and follow-up reports of barriers used by sexually active women before and after intervention, a reduction in reports of unsafe sexual encounters was demonstrated. The reduction could be attributed directly to adoption of the female condom. Although some women who had used male condoms previously adopted the female condom, most of those who did so had not used the male condom previously. Since neither theoretical objection to the hierarchical model is sustained in this population, fresh weight is given to emphasizing choice of barriers, especially to women who are at high risk and relatively disempowered. As experience with the female condom grows and its unfamiliarity decreases, it would seem appropriate to encourage women who do not succeed with the male condom to try to use the female condom, over which they have more control.  (+info)

(3/993) Harm reduction: Australia as a case study.

This paper explicates the term, "harm reduction"; demonstrates that harm reduction has a long tradition; and uses one country, Australia, as a case study. Harm reduction can be understood as "policies and programs which are designed to reduce the adverse consequences of mood altering substances without necessarily reducing their consumption"; it is consistent with the best traditions of both medicine and public health. Although it is difficult to interpret trends in mortality from alcohol, tobacco, and illicit drugs to determine whether harm reduction in Australia "worked", the effectiveness of harm-reduction policies and programs in controlling HIV among injecting drug users (IDUs) seems extremely strong and suggests that benefits of harm-reduction programs for other drugs will become apparent in time.  (+info)

(4/993) Methadone treatment by general practitioners in Amsterdam.

In Amsterdam, a three-tiered program exists to deal with drug use and addiction. General practitioners form the backbone of the system, helping to deal with the majority of addicts, who are not criminals and many of whom desire to be free of addiction. Distinctions are made between drugs with "acceptable" and "unacceptable" risks, and between drug use and drug-related crime; patients who fall into the former categories are treated in a nonconfrontational, nonstigmatizing manner; such a system helps prevent the majority of patients from passing into unacceptable, criminalized categories. The overall program has demonstrated harm reduction both for patients and for the city of Amsterdam.  (+info)

(5/993) Recent developments in maintenance prescribing and monitoring in the United Kingdom.

After a brief historical review of British drug legislation and public and governmental attitudes, this paper describes the wide range of policies and practices that have appeared since the explosion of illicit drug abuse in the 1960s. The spectrum goes from a reluctance to prescribe at all to maintenance on injectable opiates. Comparisons are made with differing attitudes to the availability of abortion in public health services. Compared with 5 years ago, about three times more methadone is being prescribed. There is a steady increase in prescriptions for injectable methadone but heroin maintenance is still rare. The "British System" permits great flexibility in the choice of opiates for maintenance. Some amphetamine-prescribing programmes also exist. Hair analysis for drugs to monitor levels of both prescribed and unprescribed drugs is a welcome and promising alternative to undignified and often misleading urine tests.  (+info)

(6/993) Harm reduction in Bern: from outreach to heroin maintenance.

In Switzerland, harm-reduction programs have the support of the national government and many localities, in congruence with much of the rest of Europe and in contrast with the United States, and take place in public settings. The threat of AIDS is recognized as the greater harm. This paper describes the overall national program and highlights the experience from one city; the program is noteworthy because it is aimed at gathering comparative data from controlled trials.  (+info)

(7/993) Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.  (+info)

(8/993) A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs.

Fourteen subjects (selected on the basis of compliance with the methadone-maintenance program prescribed by the consultant psychiatrist in charge of their treatment) undergoing opiate detoxification by methadone-replacement therapy were studied to determine if a relationship exists between the dose of methadone prescribed and the urinary excretion of methadone and/or its primary metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). After the derivation of this relationship, it was hoped that the urinary concentrations of methadone and/or EDDP could be used as a noninvasive technique to monitor the methadone compliance of 56 drug abusers. Despite statistically significant correlations (p<0.001) between methadone dose and urine concentrations of methadone and EDDP, the large variation in concentrations measured in the urine of drug abusers negated the possibility of any clear-cut relationship being confirmed. However, it may be possible to use excretion data to monitor individual compliance but only through long-term monitoring of individual subjects to establish their own intraindividual variation in excretion patterns.  (+info)



fatal overdose of methadone


  • Accidental ingestion of Methadone Hydrochloride, especially by children, can result in fatal overdose of methadone (see WARNINGS). (nih.gov)

buprenorphine


  • Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. (drugabuse.gov)
  • The purpose is to study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone/buprenorphine in opiate-dependent patients following a substitution program. (clinicaltrials.gov)
  • The pupil diameter measured in scotopic .conditions (via infrared camera) at the hypothetical peak effect of either methadone or buprenorphine. (clinicaltrials.gov)

hydrochloride


  • Proper dosing and titration are essential and Methadone Hydrochloride should only be prescribed by healthcare professionals who are knowledgeable in the use of methadone for detoxification and maintenance treatment of opioid addiction. (nih.gov)
  • Monitor for respiratory depression, especially during initiation of Methadone Hydrochloride or following a dose increase. (nih.gov)
  • Closely monitor patients with risk factors for development of prolonged QT interval, a history of cardiac conduction abnormalities, and those taking medications affecting cardiac conduction for changes in cardiac rhythm during initiation and titration of Methadone Hydrochloride (see WARNINGS). (nih.gov)
  • Methadone Hydrochloride contain methadone, an opioid agonist and Schedule II controlled substance with an abuse liability similar to other opioid agonists, legal or illicit (see WARNINGS). (nih.gov)
  • Methadone Hydrochloride Powder, an opioid agonist, is for oral administration only and is used in the preparation of a liquid by dissolving the powder in an appropriate vehicle. (nih.gov)
  • Methadone hydrochloride is chemically described as 3-heptanone,6-(dimethylamino)-4,4-diphenyl-, hydrochloride. (nih.gov)
  • Methadone hydrochloride is a white, essentially odorless, bitter-tasting crystalline powder. (nih.gov)
  • Methadone hydrochloride has a melting point of 235°C, a pKa of 8.25 in water at 20°C, a solution (1 part per 100) pH between 4.5 and 6.5, a partition coefficient of 117 at pH 7.4 in octanol/water. (nih.gov)

Clinics


  • State officials and methadone clinic operators defended the clinics' practice of giving drug addicts take-home doses of methadone, telling a legislative panel the doses help patients re-establish normal lives. (topix.com)
  • Methadone clinics are just legalized drug dealers. (topix.com)
  • My point is, people are getting methadone at clinics and driving away. (butlereagle.com)
  • Yet we, the taxpayers, pay for this plus, in many cases, mileage allowance, bus fare, or even cab fare for some people to get to and from the methadone clinics. (butlereagle.com)
  • These people who are going to methadone clinics dug the hole, so let them dig their way out - but on our conditions. (butlereagle.com)
  • In response to this situation, China introduced methadone maintenance treatment (MMT) in 2004, which is now dispensed by 701 clinics serving 295,000 clients. (clinicaltrials.gov)

DOLOPHINE


  • The concomitant use of DOLOPHINE Tablets with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may result in an increase in methadone plasma concentrations, which could cause potentially fatal respiratory depression. (nih.gov)

opioid


  • Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. (nih.gov)
  • For detoxification and maintenance of opioid dependence, methadone should be administered in accordance with the treatment standards cited in 42 CFR Section 8, including limitations on unsupervised administration (see INDICATIONS AND USAGE). (nih.gov)
  • What is the influence of methadone on postoperative analgesia after lumbar interbody fusion in opioid naïve patients or patients who are taking less than equivalent of 15 mg IV morphine each day? (clinicaltrials.gov)
  • What is the incidence of opioid related postoperative side effects after the administration of methadone in the operating room? (clinicaltrials.gov)
  • We hypothesize that 0.2 mg/kg of methadone will result in decreased postoperative hydromorphone consumption compared to hydromorphone alone in opioid naïve patients or patients who are taking less than the equivalent of 15 mg IV morphine a day undergoing lumbar interbody fusion. (clinicaltrials.gov)
  • We hypothesize that the incidence of opioid related postoperative side effects will not be increased by the administration of methadone in the operating room. (clinicaltrials.gov)
  • As a single isomer, orally available d-Methadone has been shown to possess NMDA antagonist properties with virtually no opioid activity at the expected therapeutic doses. (prnewswire.com)
  • In contrast, racemic methadone is a long-acting narcotic used in the treatment of various pain states and as a substitution therapy in opioid addiction and associated with typical opioid side effects. (prnewswire.com)

heroin


  • I have been sober off of pain meds and heroin for almost 6 months and for about 5 months I have been on Methadone Maintenance. (medhelp.org)
  • Medically prescribed heroin is more cost-effective than methadone for treating long-term users, researchers claim. (dailymail.co.uk)
  • The controversial study found patients treated with the prescribed heroin were more likely to stay in treatment or quit the drug altogether than patients treated with oral methadone. (dailymail.co.uk)
  • Those in the heroin group were also more likely to live longer than someone receiving methadone maintenance therapy. (dailymail.co.uk)
  • The NAOMI study was a randomised trial aimed at testing whether medically prescribed heroin was more effective than methadone therapy for individuals who were not currently benefiting from conventional treatment. (dailymail.co.uk)
  • Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients. (drugabuse.gov)
  • Reports on a study to investigate the use of methadone maintenance for heroin addicts wait-listed for a treatment program to encourage their likelihood to enroll in the program. (drugabuse.gov)
  • My own brother, was addicted to heroin, is now on a methadone maintenance program. (topix.com)

Warnings


  • Respiratory depression, including fatal cases, have been reported during initiation and conversion of patients to methadone, and even when the drug has been used as recommended and not misused or abused (see WARNINGS). (nih.gov)

clinic


  • HCC participants will be offered on-site hepatitis A and B combination vaccination at the methadone clinic. (clinicaltrials.gov)

doses


  • At all doses tested, d-Methadone significantly decreased immobility of rats compared to the vehicle, suggesting antidepressant-like activity. (prnewswire.com)
  • In addition, the effect of d-Methadone on immobility at the two highest doses tested was larger than the effect seen with ketamine, a noncompetitive NMDA receptor antagonist that has been thoroughly characterized in this model and has demonstrated rapid onset of activity in several clinical studies targeting treatment of depression, but has also been shown in multiple studies to present a high risk of toxicity. (prnewswire.com)

patients


  • Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs. (drugabuse.gov)
  • Describes a study of unemployed methadone patients and the use of assertive outreach and motivational techniques to improve the patients' employment outlook. (drugabuse.gov)
  • This randomized clinical trial will examine the effectiveness of a strategy of HIV and Hepatitis Care Coordination (HCC) consisting of testing, education, counseling and vaccination for methadone maintenance patients compared with standard Testing, Education, and Counseling (TEC). (clinicaltrials.gov)

puts


  • U don't realize what a fog methadone puts u in! (medhelp.org)

Drug


  • I have had 2 brother in laws on Methadone and they never have weaned them off the drug.One brother in law no longer takes it because he is dead. (topix.com)
  • The patent contains claims that provide broad coverage for d-Methadone as a treatment for psychological and psychiatric disorders, including depression, anxiety, fatigue, and mood instability including pseudo-bulbar affect (PBA) for which there is currently only one U.S. Food and Drug Administration (FDA) approved treatment. (prnewswire.com)

treatment


  • QT interval prolongation and serious arrhythmia ( torsades de pointes ) have occurred during treatment with methadone. (nih.gov)
  • Methadone treatment centers are not foci for serious criminal activity, according to a study that used crime reports and global positioning data to compare crime rates at various distances around methadone centers, hospitals, convenience stores, and residential neighborhoods. (drugabuse.gov)
  • Patent contains claims that provide broad coverage for d-Methadone as a treatment for psychological and psychiatric disorders, including depression, anxiety, fatigue, and mood instability including pseudo-bulbar affect (PBA). (prnewswire.com)
  • The new d-Methadone patent application is entitled "d-Methadone for the Treatment of Psychiatric Symptoms. (prnewswire.com)
  • This is a key milestone for Relmada that significantly strengthen Relmada's positon overall patent portfolio and support our continuing development program for d-Methadone, which has shown the potential to offer efficacy benefits similar to ketamine in the treatment of depression and other psychiatric disorders, but with significantly reduced risk of toxicity based on three completed Phase I studies," said Sergio Traversa , CEO of Relmada Therapeutics. (prnewswire.com)

effect


  • The peak respiratory depressant effect of methadone occurs later, and persists longer than the peak analgesic effect, especially during the initial dosing period. (nih.gov)

kick


  • Once you become addicted to the methadone, it is a lot harder to kick that habit. (medhelp.org)

taken


  • I've never taken methadone much, only a few times when I didn't have anything else to take someone gave me a few. (medhelp.org)
  • Methadone can cause serious unwanted effects if taken by adults who are not used to strong narcotic pain medicines, children, or pets. (mayoclinic.org)
  • I've taken methadone over 7yrs and I always used to think why can't I remember anything? (medhelp.org)

pain


  • The activation of NMDA receptors has been associated with both depression and neuropathic pain and it is expected that d-Methadone will have a role in depression and pain management by blocking this activity. (prnewswire.com)

cause


  • bezos cause memory loss over long term use but do doed methaadone so you got a double edge sward sounds like your comingo off the methadone I can help you with that I also detoxed from benzos dont do both at the same time 1 then the othere good luck and God bless. (medhelp.org)

result


  • In addition, discontinuation of concomitantly used cytochrome P450 3A4 2B6, 2C19, or 2C9 inducers may also result in an increase in methadone plasma concentration. (nih.gov)

last


  • She landed in the hospital the last time she did methadone, barely able to breathe, was finally diagnosed with COPD. (medhelp.org)

study


  • Clinical development plans for Phase II d-Methadone proof-of-concept study are underway. (prnewswire.com)
  • We look forward to initiating a Phase II proof-of-concept study with d-Methadone in depression as soon as feasible. (prnewswire.com)
  • In May 2016 , Relmada reported positive results from an in vivo study to determine whether d-Methadone elicits antidepressant-like effects after a single administration based on results of the forced swim test, a well-validated animal model to predict antidepressant effects. (prnewswire.com)

program


  • I don't know a lot about the methadone program, nor politics, but I have known what it's like to be an addict, and here's the way I see it. (topix.com)

people


  • They get these people hooked on methadone and then they just leave themn to rot. (topix.com)

remember


  • I remember her telling me that when she took the methadone, she seemed to struggle to breathe. (medhelp.org)