Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)Narcotics: Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.Opiate Substitution Treatment: Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.Opioid-Related Disorders: Disorders related or resulting from abuse or mis-use of opioids.Heroin Dependence: Strong dependence, both physiological and emotional, upon heroin.Methadyl Acetate: A narcotic analgesic with a long onset and duration of action.Buprenorphine: A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Neonatal Abstinence Syndrome: Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.Heroin: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.PyrrolidinesDrug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Dextropropoxyphene: A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.Substance Abuse, Intravenous: Abuse, overuse, or misuse of a substance by its injection into a vein.Narcotic Antagonists: Agents inhibiting the effect of narcotics on the central nervous system.Street Drugs: Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.Substance-Related Disorders: Disorders related to substance abuse.Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Opium: The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.Oxidoreductases, N-DemethylatingStereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Therapeutic Community: Psychotherapeutic technique which emphasizes socioenvironmental and interpersonal influences in the resocialization and rehabilitation of the patient. The setting is usually a hospital unit or ward in which professional and nonprofessional staff interact with the patients.Directly Observed Therapy: A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.PrisonersDose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

*  A Methadone Maintenance Treatment Outcome Study in Three Provinces in China - Full Text View - ClinicalTrials.gov

An intensive methadone maintenance treatment (MMT) provider training on methadone dosage may be effective in increasing the ... Drug Information available for: Methadone Methadone hydrochloride Genetic and Rare Diseases Information Center resources: ... Training on methadone dosing provided to health care providers working in methadone maintenance clinics ... Training on methadone dosing provided to health care providers working in methadone maintenance clinics ...

*  Utilization of on-site primary care services by HIV-seropositive and seronegative drug users in a methadone maintenance program...

A 16-month prospective study was conducted within an ongoing cohort study of HIV infection at a New York City methadone program ... their use by human immunodeficiency virus HIV-seropositive and seronegative injecting drug users within an outpatient methadone ... A 16-month prospective study was conducted within an ongoing cohort study of HIV infection at a New York City methadone program ... Utilization of on-site primary care services by HIV-seropositive and seronegative drug users in a methadone maintenance program ...

*  Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.

... methadone and the formation of racemic 2-ethylidene-1,5-dim.. ... Abstract To clarify the oxidative metabolism of methadone (R)- ... methadone. CYP2C8 is also involved in the metabolism of methadone, but its contribution to the metabolism of (R)-methadone was ... methadone. However, it has different stereoselectivity toward (R)- and (S)-methadone. In recombinant CYP3A4, the metabolic ... But for the metabolism of (S)-methadone, the roles of CYP2C8 and CYP3A4 appeared equal. Although CYP2D6 is involved in the ...

*  Methadone in Neuropathic Pain - Full Text View - ClinicalTrials.gov

Experimental: Methadone Drug: Methadone Patients in the methadone arm will be supplied with 2.5 mg tablets. The dose will ... Early research suggests that methadone may be a good, inexpensive drug to treat neuropathic pain. Methadone is available in a ... Methadone in Neuropathic Pain. This study is currently recruiting participants. See Contacts and Locations ... to determine if methadone is an effective opioid for the treatment of chronic neuropathic pain [ Time Frame: 16 weeks ]. ...

*  Methadone Versus Placebo in Spine Fusion - Full Text View - ClinicalTrials.gov

Methadone. Analgesics, Opioid. Narcotics. Central Nervous System Depressants. Physiological Effects of Drugs. Analgesics. ... Methadone Versus Placebo in Spine Fusion. This study has been withdrawn prior to enrollment. ... The Effect of Methadone on Perioperative Analgesia After Posterior Lumbar Fusion - A Randomized, Placebo-controlled, Double- ... What is the influence of methadone on postoperative analgesia after lumbar interbody fusion in opioid naïve patients or ...

*  DailyMed - METHADONE HYDROCHLORIDE- methadone hydrochloride powder

Methadone Hydrochloride contains methadone, an opioid agonist and a Schedule II controlled substance. Methadone can be abused ... METHADONE HYDROCHLORIDE (UNII: 229809935B) (METHADONE - UNII:UC6VBE7V1Z). METHADONE HYDROCHLORIDE. 1 g in 1 g. ... METHADONE HYDROCHLORIDE- methadone hydrochloride powder To receive this label RSS feed. Copy the URL below and paste it into ... The effects of methadone on the QT interval have been confirmed in in vivo laboratory studies, and methadone has been shown to ...

*  Methadone safeguards

... Jim Harff Butler Township March 9, 2013 Letters to the Editor ... My point is, people are getting methadone at clinics and driving away. They are there because they have had a drug problem in ... These people who are going to methadone clinics dug the hole, so let them dig their way out - but on our conditions. ... or even cab fare for some people to get to and from the methadone clinics. ...

*  Gender differences in vocational needs and outcomes for methadone treatment clients | RTI

Data from a pilot randomized field experiment conducted from 1990 to 1992 in three methadone treatment programs were analyzed ... Karuntzos, G., Caddell, J., & Dennis, M. (1994). Gender differences in vocational needs and outcomes for methadone treatment ... Data from a pilot randomized field experiment conducted from 1990 to 1992 in three methadone treatment programs were analyzed ...

*  DMOZ - Health: Addictions: Substance Abuse: Methadone Maintenance

Methadone Maintenance is the most tested and proven way to cure opiate/heroin addiction. It has been used for 30 years, yet ... The Methadone Maze About the journey through the "maze" of methadone treatment - making sense of the side effects and the ... "Health ... Methadone Maintenance" search on: AOL - Ask - Bing - DuckDuckGo - Gigablast - Google - ixquick - Yahoo - Yandex - ... Methadone Grows as Killer Drug New York Times article about the increase in recreational use of this drug in the United States ...

*  Methadone Maintenance Treatment (MMT) Care for HIV Prevention - Full Text View - ClinicalTrials.gov

Methadone. Analgesics, Opioid. Narcotics. Central Nervous System Depressants. Physiological Effects of Drugs. Analgesics. ... Methadone Maintenance Treatment (MMT) Care for HIV Prevention. This study has been completed. ... Methadone Maintenance Treatment (MMT) Care for HIV Prevention: A Randomized Controlled Trial (MMT2). ... In response to this situation, China introduced methadone maintenance treatment (MMT) in 2004, which is now dispensed by 701 ...

*  Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients - Full Text View - ClinicalTrials.gov

During the first week of induction onto methadone, participants will be administered increasing doses of methadone starting at ... Participants may be transferred from other methadone maintenance programs, including the WHVA methadone program. ... This methadone dose will be adjusted for stabilization of opiate withdrawal symptoms using a flexible dosing from 40 mg up to ... This range has been found to be adequate for the vast majority of patients receiving methadone in our program and is designed ...

*  Methadone Effects on Zidovudine (ZDV, AZT) Disposition - Full Text View - ClinicalTrials.gov

Opiate addiction or prior enrollment in a methadone treatment program (methadone recipients only). ... Since daily methadone maintenance is the major chemical treatment for injection drug abuse, it is important to determine the ... Since daily methadone maintenance is the major chemical treatment for injection drug abuse, it is important to determine the ... Methadone. Drug Interactions. Drug Therapy, Combination. Acquired Immunodeficiency Syndrome. AIDS-Related Complex. Zidovudine. ...

*  Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients - Full Text View - ClinicalTrials.gov

Methadone is used treat addicts and to treat severe pain. In order to find the safest way to use methadone with PIs, it is ... Methadone is extensively used in the maintenance treatment of addicts and in the management of severe pain. In order to use ... Methadone. HIV-1. Dose-Response Relationship, Drug. Drug Interactions. Drug Therapy, Combination. Saquinavir. Adolescent ... Methadone. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Anti-HIV Agents. Anti-Retroviral Agents. ...

*  Laconia methadone clinic challenges police order - News - seacoastonline.com - Portsmouth, NH

The company that hopes to open a methadone clinic in Laconia doesn't believe it should have to have a police officer there ... Laconia methadone clinic challenges police order. Thursday. Feb 26, 2009 at 8:33 AM ... LACONIA, N.H. (AP) The company that hopes to open a methadone clinic in Laconia doesn't believe it should have to have a police ... LACONIA, N.H. (AP) The company that hopes to open a methadone clinic in Laconia doesn't believe it should have to have a police ...

*  Overview Of Methadone East Northport NY - East Northport NY, overview of methadone, East Northport NY methadone metabolism,...

Methadone is also an analgesic. Methadone is basically recommended for the chronic drug abusers. Methadone has been found to be ... Methadone is an opioid. Methadone is synthetic by nature. ... KNOWING METHADONE. Methadone is an Opioid. Methadone is ... Overview Of Methadone East Northport NY. Methadone is an opioid. Methadone is synthetic by nature. Methadone is also an ... Nonetheless, the methadone withdrawal symptoms linger more than the latter.. THE METHADONE LAUNCHER Methadone was commercially ...

*  What works in drug addiction? | BJPsych Advances

A classic double-blind study involved 100 heroin addicts in Hong Kong who were randomised to methadone maintenance or methadone ... Another UK trial found no advantage between injectable methadone and oral methadone (Strang et al, 2000). ... minimum-contact methadone maintenance; methadone maintenance plus standard drug counselling three times weekly; and an enhanced ... Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance. ...

*  Butler, PA Methadone Clinics

Read reviews on top methadone clinics in Butler, Pennsylvania on our site. ... More Methadone Clinics in Butler. Need help choosing the best methadone clinic in your area? Call, Chat or Email us Now. ...

*  Methadone Linked to Sudden Cardiac Deaths - Parker Waichman LLP

Tagged With: Cardiac, deaths, Methadone. Contact Form. FREE CONSULTATION 24/7/365 1-800-968-7529 Fill out this form for FREE. ... The study on methadone side effects, described in the January 2008 issue of The American Journal of Medicine, was based on an ... Methadone Linked to Sudden Cardiac Deaths. Posted: January 10, 2008. A new study by Oregon Health & Science University ... You are here: Home / Defective Drugs / Methadone Linked to Sudden Cardiac Deaths ...

*  Methadone Question - Addiction: Substance Abuse - MedHelp

I have been sober off of pain meds and heroin for almost 6 months and for about 5 months I have been on Methadone Maintenance. ... Methadone Question. I have been sober off of pain meds and heroin for almost 6 months and for about 5 months I have been on ... I was on Methadone Maintenance for 7 years at doses reaching in the hundreds and hundreds of milligrams a day. I just found ... I was on Methadone Maintenance for 7 years at doses reaching in the hundreds and hundreds of milligrams a day. I just found ...

*  Take-home methadone concerns lawmakers - The Indianapolis Star - Discussion on Topix

Topix › Indiana › Marion County › Indianapolis › Take-home methadone concerns lawmakers Take-home methadone concerns lawmakers ... Methadone clinics are just legalized drug dealers. I have had 2 brother in laws on Methadone and they never have weaned them ... There are 743 comments on the The Indianapolis Star story from Sep 12, 2007, titled Take-home methadone concerns lawmakers. In ... I don't know a lot about the methadone program, nor politics, but I have known what it's like to be an addict, and here's the ...

*  Getting off Methadone

I'm 30 and I've been on Methadone for 8 years now. In 2011 I did get off it, but I started taking >>>>>> again - just so I ... Getting off Methadone. I'm 30 and I've been on Methadone for 8 years now. In 2011 I did get off it, but I started taking ... If you have managed to get down to 8ml of Methadone, I would suggest you stay with Methadone, and SLOWLY taper 1ml when you ... Methadone is the end of life... I am 6 months off and never ever looked back... There a few people on here regularly that have ...

*  Methadone News » Topix

News for Methadone continually updated from thousands of sources on the web : LETTER: Different drug treatment approach needed ... Methadone News. News on Methadone continually updated from thousands of sources around the net. ... Drug users say methadone formula switch contributed to B.C.a s opioid crisis Sunday Sep 3 , Lethbridge Herald , ... Methadone clinics in Houston are reopening after Harvey Friday Sep 8 , Daily Mail , ...

*  Methadone: Side Effects & Withdrawal

Methadone HCl Intensol; Methadose; Methadose Sugar-Free), used to treat drug addiction and moderate to severe pain. Side ... home / chronic pain center / chronic pain a-z list / methadone liquid-oral index / methadone, dolophine, methadone hcl intensol ... methadone, Dolophine, Methadone HCl Intensol, Methadose, Methadose Sugar-Free. *What is methadone liquid-oral, and how does it ... methadone, Dolophine, Methadone HCl Intensol, Methadose, Methadose Sugar-Free Related Diseases. *methadone, Dolophine, ...

*  Smashwords - Books Tagged 'methadone'

Books tagged: methadone The adult filter is active; there may be additional content. To view this content, click the "Adult ... A mutual friend pleaded with him to write her and try to help; she wanted to break the chain of her addiction to methadone. A ...

*  Methadone Realities . Radio | OPB

Methadone Realities. by Jaymee Cuti OPB , Aug. 17, 2011 9:25 a.m. , Updated: April 2, 2015 6:22 a.m. ...

Methadone clinic: A methadone clinic is a clinic which has been established for the dispensing of methadone (Dolophine), a schedule II opioid analgesic, to those who abuse heroin and other opioids. The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone.Uniform State Narcotic Drug Act: The National Conference of Commissioners on Uniform State Laws developed the Uniform State Narcotic Drug Act in 1934 due to the lack of restrictions in the Harrison Act of 1914. The act was a revenue-producing act and, while it provided penalties for violations, it did not give authority to the states to exercise police power regarding either seizure of drugs used in illicit trade or punishment of those responsible.Comfort Food (novel): Comfort Food: A Novel by Noah Ashenhurst contains a cast of characters: a romantic academic, a self-assured young writer, an enigmatic musician, a slacker, a wealthy mountaineer, and a former heroin addict—characters whose lives intersect in the unique, award-winning debut novel.NoracymethadolAgonist–antagonistOpioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.Neonatal withdrawalDrug test: A drug test is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers screening for drugs prohibited by law (such as cannabis, cocaine and heroin) and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC (blood alcohol content).PyrrolidineOpioid overdose: .0, -Morphia (disambiguation): Morphia, also called morphine, is a highly potent opiate analgesic drug.DextropropoxypheneList of drug interactions: The following is a list of interactions with various prescription and over-the counter drugs:Substance-related disorderBenzodiazepine withdrawal syndromeOpium lampSharpless asymmetric dihydroxylation: Sharpless asymmetric dihydroxylation (also called the Sharpless bishydroxylation) is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol.Palladia (social services organization): Palladia, Inc. is a social services organization in New York City, working with individuals and families challenged by addiction, homelessness, AIDS, domestic violence, poverty and trauma.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Stateville Penitentiary Malaria Study: The Stateville Penitentiary malaria study was a controlled study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois in the 1940s. The study was conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.CodeineLow-dose naltrexone: Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as multiple sclerosis. Naltrexone is typically prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist.

(1/993) Solid-phase microextraction for cannabinoids analysis in hair and its possible application to other drugs.

This paper describes the application of solid-phase microextraction (SPME) to cannabis testing in hair. Fifty milligrams of hair was washed with petroleum ether, hydrolyzed with NaOH, neutralized, deuterated internal standard was added and directly submitted to SPME. The SPME was analyzed by GC-MS. The limit of detection was 0.1 ng/mg for cannabinol (CBN) and delta9-tetrahydrocannabinol (THC) and 0.2 ng/mg for cannabidiol (CBD). THC was detected in a range spanning from 0.1 to 0.7 ng/mg. CBD concentrations ranged from 0.7 to 14.1 ng/mg, and CBN concentrations ranged from 0.4 to 0.7 ng/mg. The effectiveness of different decontamination procedures was also studied on passively contaminated hair. The proposed method is also suitable for the analysis of methadone in hair; cocaine and cocaethylene can be detected in hair with SPME extraction after enzymatic hydrolysis.  (+info)

(2/993) Safer sex strategies for women: the hierarchical model in methadone treatment clinics.

Women clients of a methadone maintenance treatment clinic were targeted for an intervention aimed to reduce unsafe sex. The hierarchical model was the basis of the single intervention session, tested among 63 volunteers. This model requires the educator to discuss and demonstrate a full range of barriers that women might use for protection, ranking these in the order of their known efficacy. The model stresses that no one should go without protection. Two objections, both untested, have been voiced against the model. One is that, because of its complexity, women will have difficulty comprehending the message. The second is that, by demonstrating alternative strategies to the male condom, the educator is offering women a way out from persisting with the male condom, so that instead they will use an easier, but less effective, method of protection. The present research aimed at testing both objections in a high-risk and disadvantaged group of women. By comparing before and after performance on a knowledge test, it was established that, at least among these women, the complex message was well understood. By comparing baseline and follow-up reports of barriers used by sexually active women before and after intervention, a reduction in reports of unsafe sexual encounters was demonstrated. The reduction could be attributed directly to adoption of the female condom. Although some women who had used male condoms previously adopted the female condom, most of those who did so had not used the male condom previously. Since neither theoretical objection to the hierarchical model is sustained in this population, fresh weight is given to emphasizing choice of barriers, especially to women who are at high risk and relatively disempowered. As experience with the female condom grows and its unfamiliarity decreases, it would seem appropriate to encourage women who do not succeed with the male condom to try to use the female condom, over which they have more control.  (+info)

(3/993) Harm reduction: Australia as a case study.

This paper explicates the term, "harm reduction"; demonstrates that harm reduction has a long tradition; and uses one country, Australia, as a case study. Harm reduction can be understood as "policies and programs which are designed to reduce the adverse consequences of mood altering substances without necessarily reducing their consumption"; it is consistent with the best traditions of both medicine and public health. Although it is difficult to interpret trends in mortality from alcohol, tobacco, and illicit drugs to determine whether harm reduction in Australia "worked", the effectiveness of harm-reduction policies and programs in controlling HIV among injecting drug users (IDUs) seems extremely strong and suggests that benefits of harm-reduction programs for other drugs will become apparent in time.  (+info)

(4/993) Methadone treatment by general practitioners in Amsterdam.

In Amsterdam, a three-tiered program exists to deal with drug use and addiction. General practitioners form the backbone of the system, helping to deal with the majority of addicts, who are not criminals and many of whom desire to be free of addiction. Distinctions are made between drugs with "acceptable" and "unacceptable" risks, and between drug use and drug-related crime; patients who fall into the former categories are treated in a nonconfrontational, nonstigmatizing manner; such a system helps prevent the majority of patients from passing into unacceptable, criminalized categories. The overall program has demonstrated harm reduction both for patients and for the city of Amsterdam.  (+info)

(5/993) Recent developments in maintenance prescribing and monitoring in the United Kingdom.

After a brief historical review of British drug legislation and public and governmental attitudes, this paper describes the wide range of policies and practices that have appeared since the explosion of illicit drug abuse in the 1960s. The spectrum goes from a reluctance to prescribe at all to maintenance on injectable opiates. Comparisons are made with differing attitudes to the availability of abortion in public health services. Compared with 5 years ago, about three times more methadone is being prescribed. There is a steady increase in prescriptions for injectable methadone but heroin maintenance is still rare. The "British System" permits great flexibility in the choice of opiates for maintenance. Some amphetamine-prescribing programmes also exist. Hair analysis for drugs to monitor levels of both prescribed and unprescribed drugs is a welcome and promising alternative to undignified and often misleading urine tests.  (+info)

(6/993) Harm reduction in Bern: from outreach to heroin maintenance.

In Switzerland, harm-reduction programs have the support of the national government and many localities, in congruence with much of the rest of Europe and in contrast with the United States, and take place in public settings. The threat of AIDS is recognized as the greater harm. This paper describes the overall national program and highlights the experience from one city; the program is noteworthy because it is aimed at gathering comparative data from controlled trials.  (+info)

(7/993) Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.  (+info)

(8/993) A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs.

Fourteen subjects (selected on the basis of compliance with the methadone-maintenance program prescribed by the consultant psychiatrist in charge of their treatment) undergoing opiate detoxification by methadone-replacement therapy were studied to determine if a relationship exists between the dose of methadone prescribed and the urinary excretion of methadone and/or its primary metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). After the derivation of this relationship, it was hoped that the urinary concentrations of methadone and/or EDDP could be used as a noninvasive technique to monitor the methadone compliance of 56 drug abusers. Despite statistically significant correlations (p<0.001) between methadone dose and urine concentrations of methadone and EDDP, the large variation in concentrations measured in the urine of drug abusers negated the possibility of any clear-cut relationship being confirmed. However, it may be possible to use excretion data to monitor individual compliance but only through long-term monitoring of individual subjects to establish their own intraindividual variation in excretion patterns.  (+info)



effects of methadone

  • The effects of methadone dose, with and without the inclusion of additional psychosocial services, will then be measured through MMT retention and illicit opioid use. (clinicaltrials.gov)
  • The subjects in this study are women enrolled in a large, multi-site, double blind study that looks at the effects of methadone and buprenorphine treatment during pregnancy. (clinicaltrials.gov)
  • The differential effects of methadone and buprenorphine on the neonatal abstinence syndrome will also be explored. (clinicaltrials.gov)

Heroin

  • Heroin and other opiates, including methadone, can cause serious withdrawal in the baby. (brighamandwomens.org)
  • Opiate refers to a subclass of opioids consisting of alkaloid compounds extracted or derived from opium that include morphine, codeine, and semisynthetic derivatives such as heroin, methadone, fentanyl, hydromorphone, and buprenorphine. (uptodate.com)

Morphine

  • The Food and Drug Administration has not even officially approved the use of methadone and morphine on infants. (inspiremalibu.com)

buprenorphine

  • See 'Substance misuse in pregnant women' and 'Methadone substitution treatment of opioid use disorder during pregnancy' and 'Buprenorphine substitution therapy of opioid use disorder during pregnancy' . (uptodate.com)
  • Additionally, infant neurobehavioral assessments and measurements of infant vagal tone will be collected to see how methadone and buprenorphine differentially affect the neonatal abstinence syndrome, or 'withdrawal' in exposed neonates. (clinicaltrials.gov)
  • Some research has shown that buprenorphine lessens the neonatal abstinence syndrome when compared to methadone. (clinicaltrials.gov)
  • Thirty methadone and 30 buprenorphine maintained women will be evaluated at 24, 28, 32 and 36 weeks gestation using a state-of-the-art computerized fetal actocardiograph and data analysis program to simultaneously evaluate fetal movement and heart rate and maternal physiologic parameters. (clinicaltrials.gov)

opioids

  • Pregnant women with substance use disorders who are dependent on opioids are generally maintained on methadone, which provides multiple benefits including improved prenatal care, reduced fetal mortality, and improved fetal growth [ 1 ]. (uptodate.com)
  • The American Congress of Obstetricians and Gynecologists suggests that medically assisted therapy with more stable opioids, such as Subutex or Methadone, will stabilize the mother until her child is born. (inspiremalibu.com)

neonates

  • Predicting length of treatment for neonatal abstinence syndrome in methadone-exposed neonates. (jefferson.edu)
  • RESULTS: Of 204 neonates born to methadone exposed mothers, the average dose at delivery was 127 mg daily (25-340 mg) with median length of treatment 32 days (1-122 days). (jefferson.edu)

dose

  • However3the average methadone dose used is relatively low. (clinicaltrials.gov)
  • An intensive methadone maintenance treatment (MMT) provider training on methadone dosage may be effective in increasing the methadone dose levels prescribed to new patients. (clinicaltrials.gov)
  • The study will evaluate the effectiveness of a tailored education program for MMT service providers using subsequent methadone dose prescribed to new patients. (clinicaltrials.gov)
  • Trimester of initial exposure (P = .33), methadone dose at delivery (P = .198), body mass index (P = .31), antidepressant use (P = .40), cigarette use (P = .76), race (P = .78), and maternal age (P = .84) did not predict length of treatment. (jefferson.edu)

pregnant

  • See 'Infants of mothers with substance use disorder' and 'Substance misuse in pregnant women' and 'Methadone substitution treatment of opioid use disorder during pregnancy' . (uptodate.com)

pregnancy

  • Previous research by this group has found that methadone treatment during pregnancy directly impacts fetal neurophysiology independently of maternal physiology. (clinicaltrials.gov)

treatment

  • Methadone treatment has became one of main actions taken in China to control the spread of HIV among drug users. (clinicaltrials.gov)

maintenance

  • STUDY DESIGN: This was a retrospective cohort study of infants treated for NAS during 2000-2006 whose mothers were on methadone maintenance at delivery. (jefferson.edu)