Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)Narcotics: Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.Opiate Substitution Treatment: Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.Opioid-Related Disorders: Disorders related or resulting from abuse or mis-use of opioids.Heroin Dependence: Strong dependence, both physiological and emotional, upon heroin.Methadyl Acetate: A narcotic analgesic with a long onset and duration of action.Buprenorphine: A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Neonatal Abstinence Syndrome: Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.Heroin: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.PyrrolidinesDrug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Dextropropoxyphene: A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.Substance Abuse, Intravenous: Abuse, overuse, or misuse of a substance by its injection into a vein.Narcotic Antagonists: Agents inhibiting the effect of narcotics on the central nervous system.Street Drugs: Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.Substance-Related Disorders: Disorders related to substance abuse.Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Opium: The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.Oxidoreductases, N-DemethylatingStereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Therapeutic Community: Psychotherapeutic technique which emphasizes socioenvironmental and interpersonal influences in the resocialization and rehabilitation of the patient. The setting is usually a hospital unit or ward in which professional and nonprofessional staff interact with the patients.Directly Observed Therapy: A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.PrisonersDose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.

*  A Methadone Maintenance Treatment Outcome Study in Three Provinces in China - Full Text View - ClinicalTrials.gov

An intensive methadone maintenance treatment (MMT) provider training on methadone dosage may be effective in increasing the ... Drug Information available for: Methadone Methadone hydrochloride Genetic and Rare Diseases Information Center resources: ... Training on methadone dosing provided to health care providers working in methadone maintenance clinics ... Training on methadone dosing provided to health care providers working in methadone maintenance clinics ...

*  Methadone Maintenance Treatment (MMT) Care for HIV Prevention - Full Text View - ClinicalTrials.gov

Methadone. Analgesics, Opioid. Narcotics. Central Nervous System Depressants. Physiological Effects of Drugs. Analgesics. ... Methadone Maintenance Treatment (MMT) Care for HIV Prevention. This study has been completed. ... Methadone Maintenance Treatment (MMT) Care for HIV Prevention: A Randomized Controlled Trial (MMT2). ... In response to this situation, China introduced methadone maintenance treatment (MMT) in 2004, which is now dispensed by 701 ...

*  Methadone in Neuropathic Pain - Full Text View - ClinicalTrials.gov

Experimental: Methadone Drug: Methadone Patients in the methadone arm will be supplied with 2.5 mg tablets. The dose will ... Early research suggests that methadone may be a good, inexpensive drug to treat neuropathic pain. Methadone is available in a ... Methadone in Neuropathic Pain. This study is currently recruiting participants. See Contacts and Locations ... to determine if methadone is an effective opioid for the treatment of chronic neuropathic pain [ Time Frame: 16 weeks ]. ...

*  Methadone Maintenance Treatment for Opioid Dependence - PDF

Methadone Maintenance Treatment for Opioid Dependence APPROVED BY COUNCIL: PUBLICATION DATE: KEY WORDS: REFERENCE MATERIALS: ... When administering methadone for methadone maintenance treatment, physicians must: Ensure that methadone is administered to ... 2010 Methadone, Methadone maintenance treatment, Opioid dependence, Methadone exemption, Delegation exemption, Rare ... Methadone administration: The provision of a dose of methadone to a patient for consumption by the patient under direct ...

*  Methadone Maintenance Treatment and Smoking Cessation - Full Text View - ClinicalTrials.gov

Subjects who have not reached a stable dose of methadone in their methadone maintenance therapy (4 weeks at a constant/fixed ... Methadone Maintenance Treatment and Smoking Cessation (MMTASC). The recruitment status of this study is unknown. The completion ... Stable on methadone maintenance (an individual is considered 'stable' if they have had a 4 week constant/fixed dose of ... Stable methadone maintenance patients receiving varenicline will be more likely to maintain abstinence than patients receiving ...

*  Hawaii Methadone Clinics

Get the treatment options you need at Hawaii methadone clinics. ... Discover the best resources and methadone clinics in Hawaii for ... Hawaii Methadone Clinics By City. Need help choosing the best methadone clinic in your area? Call, Chat or Email us Now. ... Then you taper off the methadone to hopefully remain drug free.. The next type is methadone maintenance treatment which is ... Choosing From Many Hawaii Methadone Clinics. Choosing a Hawaii methadone clinic can be one of the most important treatment ...

*  Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1 - Full Text View - ClinicalTrials.gov

Methadone. Analgesics, Opioid. Narcotics. Central Nervous System Depressants. Physiological Effects of Drugs. Analgesics. ... Adherence Depression Heroin Dependence Methadone Motivational Interviewing Substance-Related Disorders Behavioral: CBT-AD ... Currently enrolled in methadone maintenance treatment for at least one month. *Current major or subsyndromal depression ( ... Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1. This study has been completed. ...

*  Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients - Full Text View - ClinicalTrials.gov

Methadone is used treat addicts and to treat severe pain. In order to find the safest way to use methadone with PIs, it is ... Methadone is extensively used in the maintenance treatment of addicts and in the management of severe pain. In order to use ... Methadone. HIV-1. Dose-Response Relationship, Drug. Drug Interactions. Drug Therapy, Combination. Saquinavir. Adolescent ... Methadone. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Anti-HIV Agents. Anti-Retroviral Agents. ...

*  Marshfield, WI Methadone Clinics

Find the best Marshfield methadone clinics at Addictions.com Browse our directory for a full list of all methadone clinics in ... More Methadone Clinics in Marshfield. Need help choosing the best methadone clinic in your area? Call, Chat or Email us Now. ...

*  Climate change methadone? « RealClimate

Methadone maintenance is one analogy, here's another:. The house (read planet) is burning down. The editors at RC would have us ... I mean is it better to let an addict die, or put them on methadone and give them a chance? They might die anyway, but is it ... Assuming the methadone analogy is reasonable, does that mean that injecting aerosols as a "temporary fix" is so wrong? The ... This seems rather apt, and like the analogous situation with heroin, methadone isn't going to be a cure. ...

*  Methadone detox - Addiction - MedHelp

Ive been on methadone since aug.22 2012 last wk. i started detox 80mg. down 5mg. last wk. today 2mgs. for every wk. now can i ... Ive been on methadone since aug.22 2012 last wk. i started detox 80mg. down 5mg. last wk. today 2mgs. for every wk. now can i ... Methadone withdrawal can be lengthy and stressful to your heart rate and BP, please do not attempt to do it without the proper ... the other thing i dont understand is what you can take with methadone. and what you cant take with it . it says some bp meds ...

*  Methadone Addiction Overdose

There is also information on the symptoms of methadone ... This article will educate you on what methadone is, how it is ... Methadone Addiction Overdose. Is Methadone Killing More Than Just Pain?. For anyone that isn't familiar with methadone, this ... Methadone Withdrawal Symptoms. When methadone is used on a regular basis, whether you are legally taking this drug or not, if ... As you can see, methadone abuse and overdose is definitely increasing.. What are the causes of Methadone Overdose?. One way a ...

*  Methadone (Oral Route) Before Using - Mayo Clinic

Information about this methadone-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Appropriate studies have not been performed on the relationship of age to the effects of methadone in the pediatric population ... which may require caution and an adjustment in the dose for patients receiving methadone. ... studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methadone in the ...

*  Methadone maintenance reduces injecting in prison | The BMJ

Methadone is provided to inmates on a maintenance treatment basis in only five countries and for detoxification … ... Methadone maintenance reduces injecting in prison. BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7039.1162b (Published 04 ...

*  Methadone/Percocet question - Addiction: Substance Abuse - MedHelp

How long does it take to withdraw from a opiat addiction of 120 7.5 Percocet and 120 10 MG Methadone HCL per month? I am a ... Anyhow, if the pain is controlled by the methadone then yea it would be worth a try to just use the methadone. If you feel any ... Anyhow, if the pain is controlled by the methadone then yea it would be worth a try to just use the methadone. If you feel any ... I wish I had her balls I went to a methadone clinic , I get dosed 45 mg of it so I will not go in to detox and I can wean ...

*  methadone and albuterol info. - Undiagnosed Symptoms - MedHelp

If a person were to ingest liquid methadone and take an albuterol breathing treatment, is there any way that a drug test (blood ... Methadone and its major metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine EDDP, are often measured in urine as part ... If a person were to ingest liquid methadone and take an albuterol breathing treatment, is there any way that a drug test (blood ... or any other kind) could show up positive for a small amount of alcohol? Someone mentioned that methadone can metabolize into ...

*  Personality Changes On Methadone - Pain Management - MedHelp

I feel that my personality is different on Methadone. I have been on 60 mgs a day for almost a year for chronic pain after ... Methadone seems to cover my pain better and longer. I take 20 three times a day. The side effects of Methadone seem to be all ... Methadone seems to cover my pain better and longer. I take 20 three times a day. The side effects of Methadone seem to be all ... Personality Changes On Methadone. I feel that my personality is different on Methadone. I have been on 60 mgs a day for almost ...

*  Methadone Diskets and Topamax Drug Interactions - Drugs.com

A Moderate Drug Interaction exists between Methadone Diskets and Topamax. View detailed information regarding this drug ... Using methadone together with topiramate may increase side effects such as dizziness, drowsiness, confusion, and difficulty ...

*  Methadone or Suboxone Success Plan

Using or thinking about using Suboxone or methadone? Work through the 15 recovery steps outlined in this article and greatly ... Next Article in Suboxone & Methadone Methadone Blind Taper - The Pros and Cons ... Work with your health team to find an optimal daily dosage of methadone or Suboxone. Lower is not always better - you want to ... This has to be done carefully - start on methadone too quickly and due to its long half life you could overdose. Start on ...

*  CAMH: Do You Know... Methadone

You are here: Home>Hospital>Health Information>Mental Health & Addiction Information A-Z>Methadone>Do You Know... Methadone ... Is methadone dangerous?. When methadone is taken as prescribed, it is very safe and will not cause any damage to internal ... What does methadone look like?. Pure methadone is a white crystalline powder. The powder is dissolved, usually in a fruit- ... Methadone is a "synthetic" opioid, which means that it is made from chemicals in a lab. Methadone was developed in Germany ...

*  oxycotin vs. methadone vs. suboxone - Addiction: Substance Abuse - MedHelp

When i came home I started going to the Veterans Hospital and was prescribed Methadone for pain, and it tu... ... methadone vs. suboxone. I am a 26 year old war veteran and while serving in iraq i was injured and given pain killers. When i ... I was wondering if any has any experience or knows if there is a way to get off oxycontin using methadone or suboxone without ... I was wondering if any has any experience or knows if there is a way to get off oxycontin using methadone or suboxone without ...

*  Possible drug interactions for Methadone - Addiction: Substance Abuse - MedHelp

I have been taking Paxil for depression and was also recently switched from morphine to Methadone for pain treatment. I read on ... Anyway I am on paxil and methadone ... I take my methadone at 5:30-6 am everyday and my Paxil around 9-9:30 pm every note and ... Anyway I am on paxil and methadone ... I take my methadone at 5:30-6 am everyday and my Paxil around 9-9:30 pm every note and ... Before the Methadone and after the pump was shut down I was eating Extra Strength Vicadin like candy (20-25 per day). Thomas I ...

*  Does Methadone really help with pain? - Addiction: Social - MedHelp

Alot of the people being prescibed Methadone have had a history of opiate us... ... Just wondering because I'm seeing aLOT more people being prescribed Methadone for pain relieve then I ever have before.. ... Does Methadone really help with pain?. Just wondering because I'm seeing aLOT more people being prescribed Methadone for pain ... The Problem With Methadone The increase in methadone deaths corresponds to the drug's increased use for pain relief, which ...

*  Is This Group For Addiction Only? - Methadone Community - MedHelp

... my tolerance to not just methadone but all opiates. Will me not being an a... ... I'm on methadone for chronic pain. My doctor and I are planning on tapering down slowly and getting off it in order to 'reset' ... I'm on methadone for chronic pain. My doctor and I are planning on tapering down slowly and getting off it in order to 'reset' ... my tolerance to not just methadone but all opiates. Will me not being an addict mess things up? I'm hoping it won't matter much ...

Methadone clinic: A methadone clinic is a clinic which has been established for the dispensing of methadone (Dolophine), a schedule II opioid analgesic, to those who abuse heroin and other opioids. The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone.Uniform State Narcotic Drug Act: The National Conference of Commissioners on Uniform State Laws developed the Uniform State Narcotic Drug Act in 1934 due to the lack of restrictions in the Harrison Act of 1914. The act was a revenue-producing act and, while it provided penalties for violations, it did not give authority to the states to exercise police power regarding either seizure of drugs used in illicit trade or punishment of those responsible.Comfort Food (novel): Comfort Food: A Novel by Noah Ashenhurst contains a cast of characters: a romantic academic, a self-assured young writer, an enigmatic musician, a slacker, a wealthy mountaineer, and a former heroin addict—characters whose lives intersect in the unique, award-winning debut novel.NoracymethadolAgonist–antagonistOpioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.Neonatal withdrawalDrug test: A drug test is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers screening for drugs prohibited by law (such as cannabis, cocaine and heroin) and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC (blood alcohol content).PyrrolidineOpioid overdose: .0, -Morphia (disambiguation): Morphia, also called morphine, is a highly potent opiate analgesic drug.DextropropoxypheneList of drug interactions: The following is a list of interactions with various prescription and over-the counter drugs:Substance-related disorderBenzodiazepine withdrawal syndromeOpium lampSharpless asymmetric dihydroxylation: Sharpless asymmetric dihydroxylation (also called the Sharpless bishydroxylation) is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol.Palladia (social services organization): Palladia, Inc. is a social services organization in New York City, working with individuals and families challenged by addiction, homelessness, AIDS, domestic violence, poverty and trauma.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Stateville Penitentiary Malaria Study: The Stateville Penitentiary malaria study was a controlled study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois in the 1940s. The study was conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.CodeineLow-dose naltrexone: Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as multiple sclerosis. Naltrexone is typically prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist.

(1/993) Solid-phase microextraction for cannabinoids analysis in hair and its possible application to other drugs.

This paper describes the application of solid-phase microextraction (SPME) to cannabis testing in hair. Fifty milligrams of hair was washed with petroleum ether, hydrolyzed with NaOH, neutralized, deuterated internal standard was added and directly submitted to SPME. The SPME was analyzed by GC-MS. The limit of detection was 0.1 ng/mg for cannabinol (CBN) and delta9-tetrahydrocannabinol (THC) and 0.2 ng/mg for cannabidiol (CBD). THC was detected in a range spanning from 0.1 to 0.7 ng/mg. CBD concentrations ranged from 0.7 to 14.1 ng/mg, and CBN concentrations ranged from 0.4 to 0.7 ng/mg. The effectiveness of different decontamination procedures was also studied on passively contaminated hair. The proposed method is also suitable for the analysis of methadone in hair; cocaine and cocaethylene can be detected in hair with SPME extraction after enzymatic hydrolysis.  (+info)

(2/993) Safer sex strategies for women: the hierarchical model in methadone treatment clinics.

Women clients of a methadone maintenance treatment clinic were targeted for an intervention aimed to reduce unsafe sex. The hierarchical model was the basis of the single intervention session, tested among 63 volunteers. This model requires the educator to discuss and demonstrate a full range of barriers that women might use for protection, ranking these in the order of their known efficacy. The model stresses that no one should go without protection. Two objections, both untested, have been voiced against the model. One is that, because of its complexity, women will have difficulty comprehending the message. The second is that, by demonstrating alternative strategies to the male condom, the educator is offering women a way out from persisting with the male condom, so that instead they will use an easier, but less effective, method of protection. The present research aimed at testing both objections in a high-risk and disadvantaged group of women. By comparing before and after performance on a knowledge test, it was established that, at least among these women, the complex message was well understood. By comparing baseline and follow-up reports of barriers used by sexually active women before and after intervention, a reduction in reports of unsafe sexual encounters was demonstrated. The reduction could be attributed directly to adoption of the female condom. Although some women who had used male condoms previously adopted the female condom, most of those who did so had not used the male condom previously. Since neither theoretical objection to the hierarchical model is sustained in this population, fresh weight is given to emphasizing choice of barriers, especially to women who are at high risk and relatively disempowered. As experience with the female condom grows and its unfamiliarity decreases, it would seem appropriate to encourage women who do not succeed with the male condom to try to use the female condom, over which they have more control.  (+info)

(3/993) Harm reduction: Australia as a case study.

This paper explicates the term, "harm reduction"; demonstrates that harm reduction has a long tradition; and uses one country, Australia, as a case study. Harm reduction can be understood as "policies and programs which are designed to reduce the adverse consequences of mood altering substances without necessarily reducing their consumption"; it is consistent with the best traditions of both medicine and public health. Although it is difficult to interpret trends in mortality from alcohol, tobacco, and illicit drugs to determine whether harm reduction in Australia "worked", the effectiveness of harm-reduction policies and programs in controlling HIV among injecting drug users (IDUs) seems extremely strong and suggests that benefits of harm-reduction programs for other drugs will become apparent in time.  (+info)

(4/993) Methadone treatment by general practitioners in Amsterdam.

In Amsterdam, a three-tiered program exists to deal with drug use and addiction. General practitioners form the backbone of the system, helping to deal with the majority of addicts, who are not criminals and many of whom desire to be free of addiction. Distinctions are made between drugs with "acceptable" and "unacceptable" risks, and between drug use and drug-related crime; patients who fall into the former categories are treated in a nonconfrontational, nonstigmatizing manner; such a system helps prevent the majority of patients from passing into unacceptable, criminalized categories. The overall program has demonstrated harm reduction both for patients and for the city of Amsterdam.  (+info)

(5/993) Recent developments in maintenance prescribing and monitoring in the United Kingdom.

After a brief historical review of British drug legislation and public and governmental attitudes, this paper describes the wide range of policies and practices that have appeared since the explosion of illicit drug abuse in the 1960s. The spectrum goes from a reluctance to prescribe at all to maintenance on injectable opiates. Comparisons are made with differing attitudes to the availability of abortion in public health services. Compared with 5 years ago, about three times more methadone is being prescribed. There is a steady increase in prescriptions for injectable methadone but heroin maintenance is still rare. The "British System" permits great flexibility in the choice of opiates for maintenance. Some amphetamine-prescribing programmes also exist. Hair analysis for drugs to monitor levels of both prescribed and unprescribed drugs is a welcome and promising alternative to undignified and often misleading urine tests.  (+info)

(6/993) Harm reduction in Bern: from outreach to heroin maintenance.

In Switzerland, harm-reduction programs have the support of the national government and many localities, in congruence with much of the rest of Europe and in contrast with the United States, and take place in public settings. The threat of AIDS is recognized as the greater harm. This paper describes the overall national program and highlights the experience from one city; the program is noteworthy because it is aimed at gathering comparative data from controlled trials.  (+info)

(7/993) Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.  (+info)

(8/993) A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs.

Fourteen subjects (selected on the basis of compliance with the methadone-maintenance program prescribed by the consultant psychiatrist in charge of their treatment) undergoing opiate detoxification by methadone-replacement therapy were studied to determine if a relationship exists between the dose of methadone prescribed and the urinary excretion of methadone and/or its primary metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). After the derivation of this relationship, it was hoped that the urinary concentrations of methadone and/or EDDP could be used as a noninvasive technique to monitor the methadone compliance of 56 drug abusers. Despite statistically significant correlations (p<0.001) between methadone dose and urine concentrations of methadone and EDDP, the large variation in concentrations measured in the urine of drug abusers negated the possibility of any clear-cut relationship being confirmed. However, it may be possible to use excretion data to monitor individual compliance but only through long-term monitoring of individual subjects to establish their own intraindividual variation in excretion patterns.  (+info)



effects of methadone

  • The effects of methadone dose, with and without the inclusion of additional psychosocial services, will then be measured through MMT retention and illicit opioid use. (clinicaltrials.gov)
  • The subjects in this study are women enrolled in a large, multi-site, double blind study that looks at the effects of methadone and buprenorphine treatment during pregnancy. (clinicaltrials.gov)
  • The differential effects of methadone and buprenorphine on the neonatal abstinence syndrome will also be explored. (clinicaltrials.gov)

dosage

  • An intensive methadone maintenance treatment (MMT) provider training on methadone dosage may be effective in increasing the methadone dose levels prescribed to new patients. (clinicaltrials.gov)

maintenance treatment

  • 3. JUSTIFICATION: Patients on methadone maintenance treatment have smoking prevalence rates of up 80-90% and consequently disproportionately high mortality compared to the general population. (clinicaltrials.gov)

treatment

  • Methadone treatment has became one of main actions taken in China to control the spread of HIV among drug users. (clinicaltrials.gov)
  • Previous research by this group has found that methadone treatment during pregnancy directly impacts fetal neurophysiology independently of maternal physiology. (clinicaltrials.gov)

study

  • The study will evaluate the effectiveness of a tailored education program for MMT service providers using subsequent methadone dose prescribed to new patients. (clinicaltrials.gov)
  • PURPOSE: The purpose of this placebo controlled study is to determine the efficacy, safety, and gender differences in using varenicline for smoking cessation in a population of stable methadone maintenance patients being treated for Opioid Dependence. (clinicaltrials.gov)

patients

  • This placebo controlled research protocol will examine varenicline's effect on smoking cessation/reduction and potential sex and gender differences in a population of methadone maintained patients. (clinicaltrials.gov)