The sebaceous glands situated on the inner surface of the eyelids between the tarsal plates and CONJUNCTIVA.
Eyelid diseases refer to various medical conditions that affect the function, structure, or appearance of the eyelids, including inflammatory, infectious, neoplastic, congenital, and traumatic disorders, which can impact vision, comfort, and overall ocular health.
Each of the upper and lower folds of SKIN which cover the EYE when closed.
The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.
Inflammation of the eyelids.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
The tear-forming and tear-conducting system which includes the lacrimal glands, eyelid margins, conjunctival sac, and the tear drainage system.
The oily substance secreted by SEBACEOUS GLANDS. It is composed of KERATIN, fat, and cellular debris.
Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters.
The hairs which project from the edges of the EYELIDS.
Passage of light through body tissues or cavities for examination of internal structures.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
Nerve cells where transmission is mediated by NITRIC OXIDE.
That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.
"Esters are organic compounds that result from the reaction between an alcohol and a carboxylic acid, playing significant roles in various biological processes and often used in pharmaceutical synthesis."
Green dyes containing ammonium and aryl sulfonate moieties that facilitate the visualization of tissues, if given intravenously. They have mostly been used in the study of kidney physiology.

Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues. (1/158)

BACKGROUND/AIMS: Androgens have been reported to influence the structural organisation, functional activity, and/or pathological features of many ocular tissues. In addition, these hormones have been proposed as a topical therapy for such conditions as dry eye syndromes, corneal wound healing, and high intraocular pressure. To advance our understanding of androgen action in the eye, the purpose of the present study was twofold: firstly, to determine whether tissues of the anterior and posterior segments contain androgen receptor protein, which might make them susceptible to hormone effects following topical application; and, secondly, to examine whether these tissues contain the mRNA for types 1 and/or 2 5alpha-reductase, an enzyme that converts testosterone to the very potent metabolite, dihydrotestosterone. METHODS: Human ocular tissues and cells were obtained and processed for histochemical and molecular biological procedures. Androgen receptor protein was identified by utilising specific immunoperoxidase techniques. The analysis of type 1 and type 2 5alpha-reductase mRNAs was performed by the use of RT-PCR, agarose gel electrophoresis, and DNA sequence analysis. All immunohistochemical evaluations and PCR amplifications included positive and negative controls. RESULTS: These findings show that androgen receptor protein exists in the human lacrimal gland, meibomian gland, cornea, bulbar and forniceal conjunctivae, lens epithelial cells, and retinal pigment epithelial cells. In addition, our results demonstrate that the mRNAs for types 1 and 2 5alpha-reductase occur in the human lacrimal gland, meibomian gland, bulbar conjunctiva, cornea, and RPE cells. CONCLUSION: These combined results indicate that multiple ocular tissues may be target sites for androgen action.  (+info)

Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. (2/158)

PURPOSE: To evaluate human corneal epithelial culture supernatant and tear fluid for the presence of activators and inhibitors of matrix metalloproteinase (MMP)-9, MMP-3, and tissue inhibitor of metalloproteinase (TIMP)-1, respectively, and to evaluate the effect of MMP-3 on the activation of MMP-9 in these specimens. METHODS: Unstimulated tear fluid was collected from patients with ocular rosacea and normal control subjects. Levels of MMP-9, MMP-3, and TIMP-1 were determined by enzyme-linked immunosorbent assay (ELISA) and/or immunoblot analysis. Supernatants from primary human corneal epithelial cultures and human tear fluid were incubated with MMP-3. Cultured epithelial cells and their supernatants were also treated with doxycycline before MMP-3 was added. Gelatin zymography was used to identify activated 82-kDa MMP-9. MMP-9 activity was assessed with a commercial MMP-9 activity assay system. RESULTS: MMP-9 and TIMP-1 were detected at significantly higher concentrations in rosacea-affected than in normal tear fluids. MMP-3 was detected exclusively in the tear fluid of patients with ocular rosacea who had corneal epithelial disease. Treatment of the supernatant and tear fluid with MMP-3 resulted in two bands with molecular weights of 92 kDa and 82 kDa, representing pro-MMP-9 and activated MMP-9, respectively. Doxycycline added to the conditioned media did not affect activation of MMP-9 by MMP-3. However, 24-hour treatment of corneal epithelial cultures with doxycycline resulted in a lower concentration and activity of MMP-9 in their supernatants. CONCLUSIONS: MMP-9 and TIMP-1 are produced by the human corneal epithelium and are present in tear fluid. MMP-3 alone is sufficient to activate MMP-9 on the ocular surface. Doxycycline does not directly inhibit this activation by MMP-3, but it decreases MMP-9 activity when added to corneal epithelial cultures.  (+info)

The instilled fluid dynamics and surface chemistry of polymers in the preocular tear film. (3/158)

Using slit lamp fluorophotometry it was demonstrated that the rate of drainage of a vehicle placed in the eye increased with increasing volume and that polymer solutions increased the thickness of the precorneal tear film (PTF). By increasing the viscosity of the delivery vehicle, (e.g., a hydroxypropylmethylcellulose polymer solutions), the PTF retention of fluorescein could be increased. The increased retention was shown to be due to an increase in the tear reservoir volume provided by the more viscous solutions. The PTF retention of fluorescein in a polyvinyl alcohol (PVA) vehicle was not as viscosity dependent, although PVA did seem to produce greater initial PTF fluorescence. This suggested that PVA initially produced a thicker PTF. The PTF retention of fluorescein by five commercial solutions did not have any relation to their wetting properties. The only good correlation with fluorescein retention in the PTF measured, seemed to be the ability of different polymer solutions to stabilize a thick layer of water as measured by the spontaneous spreading of polymer molecules at the air/liquid interface on wet glass surfaces. This model was designed to simulate tear film spreading in vivo. The results suggest that different polymer solutions may produce thicker PTF's than normal by virtue of their ability to drag water with them as they spread over the ocular surface with each blink. Mechanisms by which polymer solutions may increase the thickness of the PTF are discussed.  (+info)

Androgen influence on the meibomian gland. (4/158)

PURPOSE: The hypothesis in the study was that androgens control meibomian gland function, regulate the quality and/or quantity of lipids produced by this tissue, and promote the formation of the tear film's lipid layer. To test this hypothesis, a study was conducted to determine whether androgen receptor protein exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen deficiency and/or treatment influences the gross morphology, neutral lipid content, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear film lipid layer. METHODS: Rat lids were obtained and processed for immunohistochemistry. Meibomian glands from intact, androgen- and/or placebo-treated rabbits were analyzed by histology, and glandular lipids were evaluated by gas chromatography, high-performance liquid chromatography (HPLC), and mass spectrometry. The rabbit tear film lipid layer was assessed by interferometry. RESULTS: In the current study androgen receptor protein existed within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated with alterations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated the fatty acid profile in the total and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influence the gross morphology of meibomian tissue or to exert a demonstrable effect on the rabbit tear film lipid layer. CONCLUSIONS: The findings show that the meibomian gland is an androgen target organ and that androgens influence the lipid profile within this tissue. However, the extent to which androgens regulate the production of these lipids and whether this action may impact tear film stability remain to be determined.  (+info)

The SAFE strategy for the elimination of trachoma by 2020: will it work? (5/158)

WHO has recently launched a programme (GET 2020) for the elimination of trachoma, the leading cause of preventable blindness. GET 2020 has adopted the SAFE strategy, a comprehensive set of control measures (Surgery for entropion/trichiasis; Antibiotics for infectious trachoma; Facial cleanliness to reduce transmission; Environmental improvements such as control of disease-spreading flies and access to clean water). The present article reviews the strengths and weaknesses of each component of the strategy. Although significant hurdles remain to be overcome there is every reason to hope that GET 2020 will be successful.  (+info)

Polychlorinated biphenyls poisoning in monkey eye. (6/158)

Poisoning by polychlorinated biphenyl(s) (PCB) in humans leads to cutaneous and ocular findings. A white, cheeselike secretion issuing from the orifice of the Meibomian gland duct when the eyelid is squeezed is one sign of this intoxiation. In the rhesus monkey, abnormal hyperkeratosis of the ductal epithelium was observed histopathologically.  (+info)

15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. (7/158)

15-Lipoxygenase-2 has a limited tissue distribution in epithelial tissues, with mRNA detected in skin, cornea, lung, and prostate. It was originally cloned from human hair rootlets. In this study the distribution of 15-lipoxygenase-2 was characterized in human skin using immunohistochemistry and in situ hybridization. Strong uniform 15-lipoxygenase-2 in situ hybridization (n = 6) and immunostaining (n = 16) were observed in benign cutaneous sebaceous glands, with expression in differentiated secretory cells. Strong 15-lipoxygenase-2 immunostaining was also observed in secretory cells of apocrine and eccrine glands. Variable reduced immunostaining was observed in skin-derived sebaceous neoplasms (n = 8). In the eyelid, Meibomian glands were uniformly negative for 15-lipoxygenase-2 in all cases examined (n = 9), and sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12). The mechanisms responsible for differential expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established. In epidermis, positive immunostaining was observed in the basal cell layer in normal skin, whereas five examined basal cell carcinomas were negative. Thus, the strongest 15-lipoxygenase-2 expression is in the androgen regulated secretory cells of sebaceous, apocrine, and eccrine glands. This compares with the prostate, in which 15-lipoxygenase-2 is expressed in differentiated prostate secretory cells (and reduced in the majority of prostate adenocarcinomas). The product of 15-lipoxygenase-2, 15-hydroxyeicosatetraenoic acid, may be a ligand for the nuclear receptor peroxisome proliferator activated receptor-gamma, which is expressed in sebocytes, and contribute to secretory differentiation in androgen regulated tissues such as prostate and sebaceous glands.  (+info)

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. (8/158)

Stearoyl-CoA desaturase (SCD) is a microsomal rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFA), mainly oleate (18:1) and palmitoleate (16:1), which are the major MUFA of membrane phospholipids, cholesterol esters and triglycerides. Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice. To investigate the physiologic functions of SCD1, we generated SCD1 null (SCD1-/-) mice. The skin and eyelid of SCD1-/- mice are deficient in triglycerides and cholesterol esters, and the eyelid also is deficient in wax esters. Furthermore, the eyelid and skin of SCD1-/- mice have higher levels of free cholesterol. SCD1-/- mice develop cutaneous abnormalities and narrow eye fissure with atrophic sebaceous and meibomian glands. Consumption of diets containing high levels of oleate, failed to restore the levels of triglycerides, cholesterol esters and wax esters in SCD1-/- mice to the levels found in the eyelid of wild-type mice. These results reveal a physiologic role of SCD in cholesterol homeostasis as well as in the de novo biosynthesis of cholesterol esters, triglycerides and wax esters required for normal skin and eyelid function.  (+info)

Meibomian glands are sebaceous glands located in the eyelids, specifically at the rim of the eyelid near the lashes. They produce an oily substance called meibum that forms the outermost layer of the tear film, helping to prevent evaporation and keep the eye surface lubricated. The Meibomian glands play a crucial role in maintaining the health and comfort of the eyes by providing stability to the tear film and protecting the eye from irritants and dryness.

Eyelid diseases refer to a variety of medical conditions that affect the function and/or appearance of the eyelids. These can include structural abnormalities, such as entropion (inward turning of the eyelid) or ectropion (outward turning of the eyelid), as well as functional issues like ptosis (drooping of the upper eyelid). Other common eyelid diseases include blepharitis (inflammation of the eyelid margin), chalazion (a blocked oil gland in the eyelid), and cancerous or benign growths on the eyelid. Symptoms of eyelid diseases can vary widely, but often include redness, swelling, pain, itching, tearing, and sensitivity to light. Treatment for these conditions depends on the specific diagnosis and may range from self-care measures and medications to surgical intervention.

Eyelids are the thin folds of skin that cover and protect the front surface (cornea) of the eye when closed. They are composed of several layers, including the skin, muscle, connective tissue, and a mucous membrane called the conjunctiva. The upper and lower eyelids meet at the outer corner of the eye (lateral canthus) and the inner corner of the eye (medial canthus).

The main function of the eyelids is to protect the eye from foreign particles, light, and trauma. They also help to distribute tears evenly over the surface of the eye through blinking, which helps to keep the eye moist and healthy. Additionally, the eyelids play a role in facial expressions and non-verbal communication.

In medical terms, "tears" are a clear, salty liquid that is produced by the tear glands (lacrimal glands) in our eyes. They serve to keep the eyes moist, protect against dust and other foreign particles, and help to provide clear vision by maintaining a smooth surface on the front of the eye. Tears consist of water, oil, and mucus, which help to prevent evaporation and ensure that the tears spread evenly across the surface of the eye. Emotional or reflexive responses, such as crying or yawning, can also stimulate the production of tears.

Blepharitis is a common inflammatory condition that affects the eyelids, specifically the eyelash follicles and the edges of the eyelids (called the "eyelid margins"). It can cause symptoms such as redness, swelling, itching, burning, and a crusty or flaky buildup on the lashes. Blepharitis can be caused by a variety of factors, including bacterial infection, skin disorders like seborrheic dermatitis or rosacea, and meibomian gland dysfunction. It is often a chronic condition that requires ongoing treatment to manage symptoms and prevent recurrence.

Dry eye syndrome, also known as keratoconjunctivitis sicca, is a condition characterized by insufficient lubrication and moisture of the eyes. This occurs when the tears produced by the eyes are not sufficient in quantity or quality to keep the eyes moist and comfortable. The medical definition of dry eye syndromes includes the following symptoms:

1. A gritty or sandy sensation in the eyes
2. Burning or stinging sensations
3. Redness and irritation
4. Blurred vision that improves with blinking
5. Light sensitivity
6. A feeling of something foreign in the eye
7. Stringy mucus in or around the eyes
8. Difficulty wearing contact lenses
9. Watery eyes, which may seem contradictory but can be a response to dryness
10. Eye fatigue and discomfort after prolonged screen time or reading

The causes of dry eye syndromes can include aging, hormonal changes, certain medical conditions (such as diabetes, rheumatoid arthritis, lupus, Sjogren's syndrome), medications (antihistamines, decongestants, antidepressants, birth control pills), environmental factors (dry air, wind, smoke, dust), and prolonged screen time or reading.

Treatment for dry eye syndromes depends on the severity of the condition and its underlying causes. It may include artificial tears, lifestyle changes, prescription medications, and in some cases, surgical procedures to improve tear production or drainage.

Sebaceous glands are microscopic, exocrine glands that are found in the dermis of mammalian skin. They are attached to hair follicles and produce an oily substance called sebum, which is composed of triglycerides, wax esters, squalene, and metabolites of fat-producing cells (fatty acids, cholesterol). Sebum is released through a duct onto the surface of the skin, where it forms a protective barrier that helps to prevent water loss, keeps the skin and hair moisturized, and has antibacterial properties.

Sebaceous glands are distributed throughout the body, but they are most numerous on the face, scalp, and upper trunk. They can also be found in other areas of the body such as the eyelids (where they are known as meibomian glands), the external ear canal, and the genital area.

Abnormalities in sebaceous gland function can lead to various skin conditions, including acne, seborrheic dermatitis, and certain types of skin cancer.

I believe you may be asking for a medical explanation or examples of substances that are referred to as "waxes." Waxes are not a specific medical term, but they can refer to various natural or synthetic esters that are insoluble in water and have a soft, waxy consistency. In a medical context, the term "waxes" might refer to:

1. Cerumen (Earwax): A yellowish waxy substance produced by glands in the ear canal. Cerumen helps protect the ear by trapping dirt, dust, and other particles and preventing them from entering the inner ear.
2. Sebaceous Waxes: These are esters found in sebum, an oily substance produced by sebaceous glands in the skin. Sebum helps keep the skin and hair moisturized and protected.
3. Cutaneous Waxes: These are lipid-rich substances secreted by specialized sweat glands called eccrine glands. They help to waterproof and protect the skin.
4. Histological Waxes: Paraffin or other waxes used in histology for tissue processing, embedding, and microtomy to prepare thin sections of tissues for examination under a microscope.

These are some examples of substances that can be referred to as "waxes" in a medical context.

The lacrimal apparatus is a complex system in the eye that produces, stores, and drains tears. It consists of several components including:

1. Lacrimal glands: These are located in the upper outer part of the eyelid and produce tears to keep the eye surface moist and protected from external agents.
2. Tear ducts (lacrimal canaliculi): These are small tubes that drain tears from the surface of the eye into the lacrimal sac.
3. Lacrimal sac: This is a small pouch-like structure located in the inner part of the eyelid, which collects tears from the tear ducts and drains them into the nasolacrimal duct.
4. Nasolacrimal duct: This is a tube that runs from the lacrimal sac to the nose and drains tears into the nasal cavity.

The lacrimal apparatus helps maintain the health and comfort of the eye by keeping it lubricated, protecting it from infection, and removing any foreign particles or debris.

Sebum is an oily, waxy substance that is produced by the sebaceous glands in the skin of mammals. It is composed mainly of triglycerides, wax esters, squalene, and free fatty acids, as well as smaller amounts of metabolites and other substances. Sebum plays an important role in the maintenance of the skin's barrier function and in the regulation of its moisture levels. It also has antimicrobial properties that help to protect the skin from infection. Excessive sebum production can contribute to the development of acne and other skin conditions.

Parasympathetic fibers, postganglionic, refer to the portion of the parasympathetic nervous system's peripheral nerves that arise from ganglia (clusters of neurons) located near or within the target organs. These postganglionic fibers are responsible for transmitting signals from the ganglia to the effector organs such as glands, smooth muscles, and heart, instructing them to carry out specific functions.

The parasympathetic nervous system is one of the two subdivisions of the autonomic nervous system (the other being the sympathetic nervous system). Its primary role is to conserve energy and maintain homeostasis during rest or digestion. The preganglionic fibers originate in the brainstem and sacral spinal cord, synapsing in the ganglia located near or within the target organs. Upon receiving signals from the preganglionic fibers, the postganglionic fibers release neurotransmitters like acetylcholine to activate muscarinic receptors on the effector organ, leading to responses such as decreased heart rate, increased gastrointestinal motility and secretion, and contraction of the urinary bladder.

Eyelashes are defined in medical terms as the slender, hair-like growths that originate from the edges of the eyelids. They are made up of keratin and follicles, and their primary function is to protect the eyes from debris, sweat, and other irritants by acting as a physical barrier. Additionally, they play a role in enhancing the aesthetic appeal of the eyes and can also serve as a sensory organ, helping to detect potential threats near the eye area.

Transillumination is a medical procedure that involves the passage of bright light through a body structure, typically fluid-filled or hollow organs, to assess their size, location, or presence of abnormalities. This technique is often used to examine structures such as the breasts, lungs, or extremities in both adults and children. The transmission of light can help identify any irregularities like tumors, cysts, or other lesions based on the differences in light transmission through normal and abnormal tissues. It's a non-invasive, relatively simple, and quick method to gain preliminary information about certain medical conditions. However, transillumination is not commonly used as a primary diagnostic tool and often serves as an adjunct to other imaging techniques or clinical examinations.

The conjunctiva is the mucous membrane that lines the inner surface of the eyelids and covers the front part of the eye, also known as the sclera. It helps to keep the eye moist and protected from irritants. The conjunctiva can become inflamed or infected, leading to conditions such as conjunctivitis (pink eye).

Salivary glands are exocrine glands that produce saliva, which is secreted into the oral cavity to keep the mouth and throat moist, aid in digestion by initiating food breakdown, and help maintain dental health. There are three major pairs of salivary glands: the parotid glands located in the cheeks, the submandibular glands found beneath the jaw, and the sublingual glands situated under the tongue. Additionally, there are numerous minor salivary glands distributed throughout the oral cavity lining. These glands release their secretions through a system of ducts into the mouth.

Diagnostic techniques in ophthalmology refer to the various methods and tests used by eye specialists (ophthalmologists) to examine, evaluate, and diagnose conditions related to the eyes and visual system. Here are some commonly used diagnostic techniques:

1. Visual Acuity Testing: This is a basic test to measure the sharpness of a person's vision. It typically involves reading letters or numbers from an eye chart at a specific distance.
2. Refraction Test: This test helps determine the correct lens prescription for glasses or contact lenses by measuring how light is bent as it passes through the cornea and lens.
3. Slit Lamp Examination: A slit lamp is a microscope that allows an ophthalmologist to examine the structures of the eye, including the cornea, iris, lens, and retina, in great detail.
4. Tonometry: This test measures the pressure inside the eye (intraocular pressure) to detect conditions like glaucoma. Common methods include applanation tonometry and non-contact tonometry.
5. Retinal Imaging: Several techniques are used to capture images of the retina, including fundus photography, fluorescein angiography, and optical coherence tomography (OCT). These tests help diagnose conditions like macular degeneration, diabetic retinopathy, and retinal detachments.
6. Color Vision Testing: This test evaluates a person's ability to distinguish between different colors, which can help detect color vision deficiencies or neurological disorders affecting the visual pathway.
7. Visual Field Testing: This test measures a person's peripheral (or side) vision and can help diagnose conditions like glaucoma, optic nerve damage, or brain injuries.
8. Pupillary Reactions Tests: These tests evaluate how the pupils respond to light and near objects, which can provide information about the condition of the eye's internal structures and the nervous system.
9. Ocular Motility Testing: This test assesses eye movements and alignment, helping diagnose conditions like strabismus (crossed eyes) or nystagmus (involuntary eye movement).
10. Corneal Topography: This non-invasive imaging technique maps the curvature of the cornea, which can help detect irregularities, assess the fit of contact lenses, and plan refractive surgery procedures.

Fluorophotometry is a medical diagnostic technique that measures the concentration of fluorescein dye in various tissues, particularly the eye. This technique utilizes a specialized instrument called a fluorophotometer which emits light at a specific wavelength that causes the fluorescein to emit light at a longer wavelength. The intensity of this emitted light is then measured and used to calculate the concentration of fluorescein in the tissue.

Fluorophotometry is often used in ophthalmology to assess the permeability of the blood-retinal barrier, which can be helpful in diagnosing and monitoring conditions such as diabetic retinopathy, age-related macular degeneration, and uveitis. It may also have applications in other medical fields for measuring the concentration of fluorescent markers in various tissues.

Nitrergic neurons are specialized cells within the nervous system that release nitric oxide (NO) as their primary neurotransmitter. Nitric oxide is a small, gaseous molecule that plays an essential role in various physiological processes, including neurotransmission, vasodilation, and immune response.

In the context of the nervous system, nitrergic neurons are involved in several functions:

1. Neurotransmission: Nitric oxide acts as a retrograde messenger, transmitting signals backward across synapses to modulate the activity of presynaptic neurons. This unique mode of communication allows for fine-tuning of neural circuits and contributes to various cognitive processes, such as learning and memory.
2. Vasodilation: Nitrergic neurons are present in blood vessel walls, where they release nitric oxide to cause vasodilation. This process helps regulate blood flow and pressure in different organs and tissues.
3. Immune response: Nitrergic neurons can interact with immune cells, releasing nitric oxide to modulate their activity and contribute to the body's defense mechanisms.
4. Gastrointestinal motility: In the gastrointestinal tract, nitrergic neurons are involved in regulating smooth muscle contractility and relaxation, which influences gut motility and secretion.
5. Reproductive system function: Nitrergic neurons play a role in the regulation of sexual behavior, penile erection, and sperm motility in the male reproductive system.

It is important to note that nitrergic neurons can be found throughout the nervous system, including the central and peripheral nervous systems, and are involved in various physiological processes. Dysfunction of these neurons has been implicated in several pathological conditions, such as neurodegenerative diseases, cardiovascular disorders, and gastrointestinal motility dysfunctions.

Infrared rays are not typically considered in the context of medical definitions. They are a type of electromagnetic radiation with longer wavelengths than those of visible light, ranging from 700 nanometers to 1 millimeter. In the field of medicine, infrared radiation is sometimes used in therapeutic settings for its heat properties, such as in infrared saunas or infrared therapy devices. However, infrared rays themselves are not a medical condition or diagnosis.

Esters are organic compounds that are formed by the reaction between an alcohol and a carboxylic acid. They are widely found in nature and are used in various industries, including the production of perfumes, flavors, and pharmaceuticals. In the context of medical definitions, esters may be mentioned in relation to their use as excipients in medications or in discussions of organic chemistry and biochemistry. Esters can also be found in various natural substances such as fats and oils, which are triesters of glycerol and fatty acids.

Lissamine Green Dyes are a type of diagnostic dye used in ophthalmology to assess the health and integrity of the tear film and the corneal surface. These dyes have a green color and are often used in conjunction with other dyes like fluorescein. When applied to the eye, Lissamine Green Dyes selectively stain areas of the eye that have been damaged or disrupted, such as areas of dryness, irritation, or inflammation.

The dye binds to denatured proteins and cellular debris on the surface of the eye, highlighting any abnormalities in the tear film or corneal epithelium. Lissamine Green Dyes can help diagnose conditions such as dry eye syndrome, exposure keratopathy, and corneal abrasions. The dye is generally considered safe for use in diagnostic procedures, but it should be used with caution and according to proper protocols to minimize any potential risks or discomfort to the patient.

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Edit and Radu Gaton, by TeÅŸu Edition, Romania & Israel, 2017, 249 p. Toxic effects of systemic retinoids on meibomian glands. ...
Toxic effects of systemic retinoids on meibomian glands. Kremer I, Gaton DD, David M, Gaton E, Shapiro A. Ophthalmic Res. 1994; ...
"What Is Meibomian Gland Dysfunction?". Webmd.com. Retrieved 24 February 2022. Leeper-Woodford, Sandra; Adkinson, Linda (2015 ... meibomian gland dysfunction muscle spasms or pain For both muscle and joint injuries, it is common to alternate both cold and ...
... and glands on the eyelids are known as meibomian glands. Sebaceous glands of the breast are also known as Montgomery's glands. ... In the eyelids, meibomian glands, also called tarsal glands, are a type of sebaceous gland that secrete a special type of sebum ... During pregnancy and lactation these glands, also called Montgomery's glands, become enlarged. Meibomian glands, in the eyelids ... A sebaceous gland, or oil gland, is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete an oily ...
... is a hair follicle mite found in the Meibomian glands of the striped field mouse, Apodemus agrarius. Mertens ... Acarina: Prostigmata: Demodicidae) from the Meibomian glands of Apodemus agrarius". Bonner zoologische Beiträge. 34 (4): 489- ...
It is mainly produced by the lacrimal gland. Some lacritin also is produced by the meibomian gland, and also by epithelial ... including the accessory lacrimal gland of Wolfring. Some lacritin is produced by the meibomian gland, and by epithelial cells ... Some lacritin is produced by the meibomian gland, and also by epithelial cells of the conjunctiva and cornea that together with ... Expression is moderate in salivary glands and slight in mammary (cancer but not or rarely normal), and thyroid glands. The ...
Individuals with meibomian gland dysfunction will have an increased rate of evaporation because the glands release lower ... Meibomian gland Dry eye Blepharitis Rolando, Maurizio; Refojo, Miguel F (1983-01-01). "Tear evaporimeter for measuring water ...
Meibomian gland dysfunction is a result of abnormalities of the meibomian glands and altered secretion of meibum, which plays ... The Meibomian glands may appear caked with oil or visibly obstructed. Cultures of the eyelid margins can be a clear indicator ... Posterior blepharitis and Meibomian gland dysfunction are frequently associated with rosacea and can be seen during an ocular ... Flaking of skin on eyelids - due to tear film suppressed by clogged meibomian glands. Gritty/burning sensation in the eye, or ...
... is used in meibomian gland dysfunction diagnosis. Meibomian gland Dry eye syndrome Blepharitis Garza-Leon, Manuel; ... A meibography is an image of the morphology of the meibomian glands. Different technologies exist to perform a meibography in a ...
Posterior blepharitis is usually due to meibomian gland dysfunction. Dermatologic conditions: there are multiple types of ... or seborrhoeic blepharitis and posterior blepharitis is due to the meibomian gland. Dermatologic conditions: there are multiple ...
Because of decreased androgen levels, the meibomian glands (the sebaceous glands on the upper and lower eyelids that open up at ... June 2002). "Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye". Annals of the New York Academy of ... effect on human meibomian gland secretions". Archives of Ophthalmology. 120 (12): 1689-1699. doi:10.1001/archopht.120.12.1689. ... "Effect of androgen deficiency on the human meibomian gland and ocular surface". The Journal of Clinical Endocrinology and ...
Each eyelid of the long-tailed vole has around 3-4 meibomian glands. Fossil remains date towards the end of the Wisconsinian ... Long-tailed voles do not usually have the hip glands, which are found in other members of the genus Microtus. These can develop ...
... and sebaceous glands which secrete sebum to lubricate the skin and hair. Meibomian glands in the eyelid secrete meibum to ... Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In ...
... e usually exit from the duct of the meibomian gland at the eyelid margin. They are usually multiple, and sometimes ...
Dry eye patients, especially with meibomian gland dysfunction exhibit higher levels of MMP-9. GRCh38: Ensembl release 89: ...
Selenium sulfide is under development for the treatment of meibomianitis (meibomian gland dysfunction) and dry eyes in topical ... 2021). "Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook". Clinical ... "ARVO 2021: Investigational Agent Containing Selenium Sulfide Shows Promise for Meibomian Gland Dysfunction". PracticeUpdate. ...
The glands of Zeis are named after German ophthalmologist Eduard Zeis (1807-68). Meibomian gland Moll's gland List of ... Glands of Zeis are unilobar sebaceous glands located on the margin of the eyelid. The glands of Zeis service the eyelash. These ... In the same area of the eyelid, near the base of the eyelashes are apocrine glands called the "glands of Moll". If eyelashes ... glands produce an oily substance that is issued through the excretory ducts of the sebaceous lobule into the middle portion of ...
McMahon, Anne; Lu, Hua; Butovich, Igor A. (2014-05-01). "A role for ELOVL4 in the mouse meibomian gland and sebocyte cell ... Meibomian glands, testes and sperm. Known mutations of ELOVL4 in humans cause diseases such as Autosomal Dominant Stargardt- ...
The meibomian glands lie within the eyelid and secrete the lipid part of the tear film. The skin is similar to areas elsewhere ... an excess of eyelid skin that may obstruct vision Gland of Moll - a modified sweat gland at the base of the eyelashes Hay-Wells ... It contains sweat glands and hairs, the latter becoming eyelashes as the border of the eyelid is met. The skin of the eyelid ... Chalazion (plural: chalazia) is caused by the obstruction of the oil glands and can occur in both upper and lower eyelids. ...
The company's Lipiflow System was FDA cleared in June 2011 for treating meibomian gland dysfunction and is currently installed ... LipiFlow Thermal Pulsation System uses heat and pressure to unblock obstructed meibomian glands to reduce dry eye symptoms. " ... 2012). "A new system, the LipiFlow, for the treatment of meibomian gland dysfunction". Cornea. 31 (4): 396-404. doi:10.1097/ico ... Korb DR, Blackie CA (August 2010). "Restoration of meibomian gland functionality with novel thermodynamic treatment device-a ...
IPL can also be used for the treatment of dry eye conditions such as meibomian gland dysfunction. IPL can treat pigmented ... to treat evaporative dry eye disease due to meibomian gland dysfunction. The technology uses a high-powered, hand-held, ... "Combination Therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) Can Improve Dry Eye Symptoms and ... "Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study". ...
There were many skin problems, chloracne, swelling of eyelids, and hypersecretion of Meibomian glands in the eyes. Babies born ...
Meyer-Bothling U, Bron AJ, Osborne NN: Evidence for an adrenergic innervation of the rat Meibomian Glands. Invest Ophthalmol ...
Examples of holocrine glands include the sebaceous glands of the skin and the meibomian glands of the eyelid. The sebaceous ... Specialized Sebaceous Glands-Zymbal's Gland, Preputial Gland, Clitoral Gland, and Perianal Gland", Boorman's Pathology of the ... Holocrine gland secretion is the most damaging (to the cell itself and not to the host which begot the cell) type of secretion ... gland is an example of a holocrine gland because its product of secretion (sebum) is released with remnants of dead cells. ...
Albietz JM, Lenton LM (October 2006). "Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland ... It lives, among other things, primarily on fatty acids in sebum secreted by sebaceous glands in the follicles. It may also be ... Elevated production of sebum by hyperactive sebaceous glands (sebaceous hyperplasia) or blockage of the follicle can cause C. ... Zouboulis CC (2011). "Acne and sebaceous gland function". Clinics in Dermatology. 22 (5): 360-6. doi:10.1016/j.clindermatol. ...
  • Meibomian glands are the oil glands that line the edge of your eyelids, near your eyelashes. (optometrists.org)
  • Blepharitis is one of the most common ocular conditions caused by an inflammation of the eyelids, usually as a result of a blockage in the meibomian glands at the base of the eyelashes. (optometrists.org)
  • The mites come out during the night to eat the skin cells of your eyelids, and lay eggs and expel waste products in your eyelid glands, and eyelash follicles. (optometrists.org)
  • MGD is a condition in which the meibomian glands, which are located in the eyelids, become blocked or inflamed. (livinghealthyrx.com)
  • Meibomian gland dysfunction (MGD) is a common eye condition that affects the meibomian glands, which are located in the eyelids. (livinghealthyrx.com)
  • This condition is characterized by inflammation of the eyelids, which can lead to blockage of the meibomian glands. (livinghealthyrx.com)
  • This therapy uses a device to deliver a gentle heat to the eyelids, which helps to unblock the meibomian glands and improve the quality of the tear film. (livinghealthyrx.com)
  • For many suffering from Dry Eye, the underlying cause of eye discomfort is not due to a tear deficiency but instead, a larger problem found within the glands of the eyelids. (laservue.com)
  • Meibomian glands are tiny glands found in our eyelids and they are responsible for the production of the protective oily (lipid) layer of the eye's tear film that both defends the eye from disease and prevents tear evaporation while your eyes are open. (laservue.com)
  • Meibomian Gland Dysfunction is a blockage of your meibomian gland, which are located in the lower and upper eyelids near the eyelash line. (boxerwachler.com)
  • When the glands are properly function this can help reduce constant redness, itching, scratchiness, dryness and even the inflammation of the eyelids. (boxerwachler.com)
  • A nurse will unblock the small obstructions and fibrosis that are causing your MGD with a paddle, rolling forceps or other forceps, applying gentle pressure to the eyelids to promote the secretion of Meibum (an essential oil) from your glands to your eyes. (drarunghosh.co.uk)
  • Meibomian glands are oil glands situated along the edge of your eyelids at the base of your eyelashes. (pacificpieroptometry.com)
  • Meibomian gland dysfunction (MGD) is a common eye condition that occurs when the Meibomian glands in the eyelids do not function properly. (optiksoptometry.ca)
  • Meibomian glands are sebaceous glands located all along both your upper and lower eyelids. (drmelaniedenton.com)
  • Its name refers to the gland located in the eyelids called the Meibomian. (shippeefamilyeyecare.com)
  • Meibomian glands (also called tarsal glands) are the tiny oil glands in the eyelids located along the margin (rim) of the eyelids. (eyemantra.org)
  • The eyes and the eyelids start getting dry, due to the lack of secretion of oil from the meibomian glands. (eyemantra.org)
  • Due to the blockage of the openings of the meibomian glands, the eyelids become sore and swollen. (eyemantra.org)
  • Blepharitis/MGD refers to low-grade inflammation of the eyelids and obstruction of the oil glands of the eyelid (Meibomian Gland Dysfunction), often in association with dandruff-like scaling of the skin at the base of the eyelashes. (wildpartyofficial.com)
  • More common than anterior blepharitis, posterior blepharitis describes inflammation of the posterior lid margin, and includes meibomian gland dysfunction (MGD), a condition that results from a dysfunction of the finger-like oil glands in the eyelids. (wildpartyofficial.com)
  • The eyelids can become sore and swollen as the glands become blocked. (wildpartyofficial.com)
  • Posterior blepharitis, which is also called Meibomian Gland Dysfunction (MGD), results when the condition affects the inside rims of the eyelids (just behind the eyelashes) which contain the meibomian glands. (wildpartyofficial.com)
  • You can also get blepharitis if the oil glands in your eyelids get clogged or irritated. (wildpartyofficial.com)
  • The meibomian glands are located along the eyelids. (ea-ny.com)
  • The glands can become clogged by oil accumulation along the eyelids, inflammation, or damaged eyelids. (ea-ny.com)
  • Meibomian gland dysfunction (MGD) is a common eye condition that affects the eyelids and can cause a variety of symptoms. (healthyorbust.org)
  • It is caused by a blockage of the meibomian glands, which are located in the eyelids and produce an oily substance that helps keep the eyes lubricated. (healthyorbust.org)
  • Meibomian glands are located in both your upper and lower eyelids, where they produce complex oily fluid that stabilizes the tear film and slows the evaporation of your tears. (harreleyecare.com)
  • Meibomian glands of CD147 knockout mice had a lower number of acini in both the superior and inferior tarsal plates of the eyelids, and were characterized by loss of lipid-filled meibocytes compared with control mice. (illinois.edu)
  • Meibomian Gland Dysfunction is often a progressive, obstructive issue affecting the glands of the eyelids, which advances from the production of normal, healthy oil into stagnant, hardened oil that can lead to gland atrophy. (eyelovethesun.com)
  • The oil in the glands of your eyelids is similar, and remember that we want oil the consistency of olive oil. (eyelovethesun.com)
  • Meibomian Gland Dysfunction (MGD) is when the oil glands in the eyelids become clogged. (eyes360.ca)
  • The Meibomian glands are located in the upper and lower eyelids and are responsible for oil secretion. (medicalnewstoday.com)
  • An update[clarification needed] was published in 2009 on the composition of human meibum and on the structures of various positively identified meibomian lipids Currently, the most sensitive and informative approach to lipidomic analysis of meibum is mass spectrometry, either with direct infusion or in combination with liquid chromatography. (wikipedia.org)
  • Meibomian gland dysfunction (MGD) is a common condition that occurs when the meibomian glands don't produce enough oil (meibum), or the oil is of poor quality. (optometrists.org)
  • These glands produce an oily substance called meibum, which helps to lubricate the eyes and prevent tears from evaporating too quickly. (optiksoptometry.ca)
  • When the glands become blocked or do not produce enough meibum, it can lead to symptoms such as dryness, redness, itching, and blurry vision. (optiksoptometry.ca)
  • Meibomian gland dysfunction is a condition when the meibomian glands can't produce enough meibum to keep the ocular surfaces well lubricated. (eyemantra.org)
  • The major function of the meibomian glands is to secrete oil (called meibum) into the tears and hence prevent the water component of the tears from drying out. (eyemantra.org)
  • Meibomian Gland Dysfunction is basically a blockage in the meibomian glands due to which they fail to secrete enough oil (meibum) that could prevent the water component of the tears from drying out. (eyemantra.org)
  • The most common cause is when the openings of the glands get clogged due to various reasons and hence the meibum secretion stops. (eyemantra.org)
  • The makeup clogs the openings of the glands and hence the glands then fail to produce enough oil (meibum) to retain the water component of the tears. (eyemantra.org)
  • Your meibomian glands control the lipids in the eye (meibum) which combine with water and mucus in the eye area to create a thin film that consistently lubricates your eyes. (midwesteyeassociates.com)
  • Meibomian Gland Dysfunction occurs when the meibomian glands fail to provide enough meibum. (midwesteyeassociates.com)
  • Intraductal meibomian gland probing is a relatively nontraumatic method to relieve the symptoms of MGD, which could mechanically open and dilate the natural orifices and ducts of the meibomian glands to remove abnormal meibum secretions. (premiumvisionsc.com)
  • Warm compresses will also unblock the glands, as a higher compress temperature will liquefy viscous meibum. (wildpartyofficial.com)
  • Optimal meibum (the oil produced from these glands) is the consistency of olive oil, while many people are experiencing meibum with the consistency of toothpaste. (eyelovethesun.com)
  • Meibomian gland assessments included in the study were expressibility of meibum, meibum quality, meibomian gland dropout by and lipid layer thickness by spectral interferometry. (uk.com)
  • n-3 fatty acid deficiency was decreased the amount of meibum secretion from meibomian gland without change of fatty acid composition. (bvsalud.org)
  • Meibomian glands in the eyelid produce lipids (meibum) that reduce tear evaporation by forming a lipid layer on top of the aqueous tear layer. (msdmanuals.com)
  • There are about 25 such glands on the upper eyelid, and 20 on the lower eyelid. (wikipedia.org)
  • Around 25 to 40 meibomian glands line the upper eyelid and 20 to 30 line the lower eyelid. (optometrists.org)
  • In fact, there are up to 40 glands like this in the upper eyelid and as many as 30 in the lower eyelid. (shippeefamilyeyecare.com)
  • There are approximately 25-40 meibomian glands in the upper eyelid and 20-30 in the lower eyelid. (eyemantra.org)
  • It results when an abnormality or blockage occurs in the small meibomian glands, located in your lower eyelid. (neweraeyecare.com)
  • These hormones may also adversely impact meibomian glands, located within the upper and lower eyelid margins. (neweraeyecare.com)
  • It addresses evaporative dry eye by unblocking the meibomian glands that secrete oily lipids. (laservue.com)
  • LipiFlow is designed to unblock the meibomian glands that secrete the oily lipids needed to produce quality tears. (laservue.com)
  • These lipids can thicken the oil produced by the meibomian glands, leading to blockages. (pacificpieroptometry.com)
  • As a result, the tiny glands are unable to produce the lipids needed to maintain the right balance for the optimum quality and functioning of the tears. (neweraeyecare.com)
  • Meibomian gland dysfunction often does not present with any symptoms in its early stages. (optometrists.org)
  • These treatments involve the removal of the meibomian glands, which can help to reduce the symptoms of dry eye. (livinghealthyrx.com)
  • The new LipiFlow treatment is designed to treat the root cause of many Dry Eye symptoms: Meibomian Gland Dysfunction (MGD). (laservue.com)
  • SAN DIEGO - Omega-3 fatty acid supplementation improves the signs and symptoms of meibomian gland dysfunction, a new study shows. (medscape.com)
  • In their study, Dr Jain and his team recruited 60 patients with moderate signs and symptoms of meibomian gland dysfunction who were not being treated for the syndrome. (medscape.com)
  • Fortunately, there are steps that you can take to unclog your meibomian glands in order to reduce the symptoms associated with MGD and improve your overall eye health with proper management . (pacificpieroptometry.com)
  • When meibomian glands become blocked, they can cause a variety of symptoms . (pacificpieroptometry.com)
  • Some patients experience these symptoms as a result of Meibomian gland dysfunction. (shippeefamilyeyecare.com)
  • Meibomian tumors (also called chalazions) don't show early obvious symptoms other than the swelling of the cyst itself. (hugspetproducts.com)
  • In fact, more than 85% of patients who visit their eye doctor due to dry eye symptoms are diagnosed with Meibomian Gland Dysfunction. (harreleyecare.com)
  • The glands may decrease tear production and cause dry eye symptoms. (neweraeyecare.com)
  • This pilot study showed that LDS improved symptoms, ocular staining, and meibomian gland function for the group that received LDS. (nih.gov)
  • Inflammation of the meibomian glands (also known as meibomitis, meibomian gland dysfunction, or posterior blepharitis) causes the glands to be obstructed by thick, cloudy-to-yellow, more opaque and viscous-like, oily and waxy secretions, a change from the glands' normal clear secretions. (wikipedia.org)
  • Is blepharitis the same as meibomian gland dysfunction? (wildpartyofficial.com)
  • Is there a difference between blepharitis and meibomian gland dysfunction? (wildpartyofficial.com)
  • Blepharitis is very common, especially among people who have meibomian gland dysfunction (MGD), rosacea or ocular rosacea, and dandruff (seborrheic dermatitis). (wildpartyofficial.com)
  • Posterior blepharitis generally is caused by meibomian gland dysfunction or rosacea. (medscape.com)
  • Chronic posterior blepharitis is associated with structural changes of the meibomian gland ducts. (medscape.com)
  • Demodex brevis is found in the meibomian glands and is common in posterior blepharitis. (medscape.com)
  • Chronic disease is treated with tear supplements, warm compresses, and occasionally oral antibiotics (eg, a tetracycline or azithromycin) for meibomian gland dysfunction or with eyelid hygiene and tear supplements for seborrheic blepharitis. (msdmanuals.com)
  • Blepharitis may be acute (ulcerative or nonulcerative) or chronic (meibomian gland dysfunction, seborrheic blepharitis). (msdmanuals.com)
  • Treatment can include warm compresses to thin the secretions and eyelid scrubs with a commercial eyelid cleanser or baby shampoo, or emptying ("expression") of the gland by a professional. (wikipedia.org)
  • Up until now, dry eye syndrome has typically been treated with prescription eye drops or artificial tears, warm compresses, punctal plugs, meibomian gland expression, dietary supplements, dry eye treatments span the spectrum. (laservue.com)
  • Warm compresses aid with the unclogging of the meibomian glands. (medscape.com)
  • Both styes and MGD are treated with warm compresses and lid massage to help with the secretion of oil from the glands. (eyes360.ca)
  • Intense Pulse Light therapy (IPL) is also effective at stimulating glands that have lost their function for which warm compresses may not be effective. (eyes360.ca)
  • Factors that contribute to meibomian gland dysfunction can include things such as a person's age and/or hormones, or severe infestation of Demodex brevis mite. (wikipedia.org)
  • Taking multiple drugs to treat 1 condition, especially for age-related conditions, can contribute to meibomian gland dysfunction. (pacificpieroptometry.com)
  • This application has proved to be an extremely effective process for clearing blockages found in the Meibomian glands. (laservue.com)
  • Intense pulsed light (IPL) treatments have also been shown to reduce inflammation and improve gland function. (wikipedia.org)
  • Meibomian Gland Dysfunction is one such cause of dry eyes and can cause inflammation of the eye and eyelid. (boxerwachler.com)
  • Inflammation from these conditions can disrupt the normal functioning of the glands. (pacificpieroptometry.com)
  • Bacteria can infect the glands, leading to inflammation and blockage. (pacificpieroptometry.com)
  • A chalazion is a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid. (furrycritter.com)
  • These treatments can help to reduce inflammation and improve the flow of oils from the meibomian glands. (healthyorbust.org)
  • For those with meibomian gland issues, discovering ways to improve the glands is an important step in decreasing inflammation and feeling better overall. (eyelovethesun.com)
  • The edges of the upper and lower lids are lubricated by an oily secretion produced by the meibomian glands. (optometrists.org)
  • These glands produce an oily substance that helps to keep the eyes lubricated and prevent dryness. (livinghealthyrx.com)
  • MGD is a condition in which the meibomian glands, which are responsible for producing the oily layer of the tear film, become blocked or inflamed. (livinghealthyrx.com)
  • These glands produce an oily substance that helps keep the eyes lubricated and comfortable. (healthyorbust.org)
  • The meibomian glands are responsible for producing the oil for that oily layer, and this layer of the tear film is so critical because it lubricates the eyes and prevents evaporation of the rest of the tear film. (eyelovethesun.com)
  • In our previously study, we reported lower tear volume in with an n-3 fatty acid deficient mice and that the docosahexaenoic acid and total n-3 fatty acid levels in these mice are significantly reduced in the meibomian gland , which secretes an oily tear product. (bvsalud.org)
  • These results suggest that the n-3 fatty acid deficiency causes the enhancement of evaporation of tear film by reducing oily tear secretion along with the decrease of meibomian gland function. (bvsalud.org)
  • These glands secrete the oil that coats the eyes and tear film, to prevent the tears from evaporating too quickly. (optometrists.org)
  • When MGD becomes a chronic problem, and the glands are constantly blocked or clogged, oil secretion is impossible and can cause permanent damage in the tear film as well as dry eye syndrome. (optometrists.org)
  • Now the glands will properly function to produce oils to help improve your tear film of your eye and help your eyes feel moister. (boxerwachler.com)
  • By matching the right treatments to the right patients, we can avoid gland loss and achieve a more stable tear film that functions properly. (optiksoptometry.ca)
  • Visible signs of Meibomian Gland Dysfunction include "white sebaceous material, a cornea that exhibits a decreased tear break-up time, or both. (wildpartyofficial.com)
  • It could be due to various reasons, such as certain medical conditions, medications, and tear gland damage. (ea-ny.com)
  • The Korb Meibomian Gland Evaluator (by Tear Science) is a hand held device that provides evaluation of meibomian gland function. (notadryeye.org)
  • When the meibomian glands are either blocked or don't function optimally, the lipid (fatty) layer of your tear film isn't rich enough to keep your eyes moist. (harreleyecare.com)
  • These glands secrete oil that allows the tear film to remain stable on the eye. (eyes360.ca)
  • Healthy glands secrete oil to prevent tear film evaporation. (neweraeyecare.com)
  • However, malfunctioning meibomian glands may cause your tears to evaporate more quickly, resulting in unstable tear film and dry eye. (neweraeyecare.com)
  • The outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) visual analog scores, ocular staining (SICCA OSS [Sjögren's International Collaborative Clinical Alliance Ocular Staining Score]), fluorescein tear breakup time (FLBUT), meibomian gland score (MGS), meibomian gland yielding liquid secretions (MGYLS) score, and line of Marx's (LOM) position. (nih.gov)
  • Nichols' study is examining both the structure of the tear film and its function in 200 patients split into two groups - those with normal ocular-surface health and those with meibomian gland dysfunction. (uab.edu)
  • To verify the detailed mechanism of the low tear volume in the n-3 fatty acid -deficient mice , we identified the very long chain fatty acids in the meibomian gland , measured the fatty acid composition in the tear product. (bvsalud.org)
  • Demodex are microscopic mites that live in the meibomian glands, and eyelashes. (optometrists.org)
  • With the same wash cloth, scrub the base of the eyelashes to express the meibomian glands and to remove any scurf, collarettes, and crusting. (medscape.com)
  • These glands are located in the eyelid directly behind the eyelashes. (medlineplus.gov)
  • As opposed to drops, which contain chemicals to clear blockage and lubricate, LipiFlow employs gentled heated pulsations to unblock and clear the meibomian glands, so your eyes can produce more of their own perfectly balanced tears. (laservue.com)
  • Under topical anaesthesia we will unblock the small obstructions and fibrosis that are blocking your meibomian glands (causing their dysfunction). (premiumvisionsc.com)
  • How do you unblock meibomian glands naturally? (wildpartyofficial.com)
  • In severe cases, surgery may be necessary to unblock the meibomian glands. (healthyorbust.org)
  • Meibomian Gland Expression is a procedure performed to cure MGD (Meibomian Gland Dysfunction) - a condition where the glands are not secreting enough oil or secreting oil that is of poor quality. (drarunghosh.co.uk)
  • As androgen deficiency has been implicated in age-related MGD in men and dihydrotestosterone affects gene expression meibomian gland cells, "it is thus possible that changes in the composition of circulating androgens in men with BPH contribute to morphological changes of meibomian glands," the authors noted in their study. (reviewofoptometry.com)
  • Since the literature has shown that over 84% of dry eye is the result of meibomian gland dysfunction (MGD), you perform a quick, but detailed evaluation of the patient's lids which shows keratinization or biofilm formation (Figure #2), plugged and reduced paste-like expression from the glands (Figure #3) and moderate redness. (nulids.com)
  • Treatments for Meibomian Gland Dysfunction range from self-administered or practitioner-administered treatments and typically involve a few methods, such as artificial tears, heat application, and manual gland expression. (midwesteyeassociates.com)
  • As we use a topical anaesthesia (eyedrops), Meibomian Gland Expression is not painful and almost all patients tolerate the procedure with little discomfort. (premiumvisionsc.com)
  • Meibomian Gland Expression takes 20 minutes and it is safe for you to drive home after treatment. (premiumvisionsc.com)
  • Can you do meibomian gland expression at home? (wildpartyofficial.com)
  • One option is meibomian gland probing, also referred to as 'expression of the meibomian gland. (harreleyecare.com)
  • The iLux and Mechanical Meibomian Gland Expression for the Treatment of Moderate and Severe Meibomian Gland Dysfunction. (who.int)
  • Meibomian glands are responsible for oil secretion (sebum) and help prevent the eyes from drying out. (hugspetproducts.com)
  • The prevalence of meibomian gland dysfunction ranges from 30.3% to 63.3% and, in Asia, the prevalence is at the top of that range, he reported. (medscape.com)
  • Prevalence of Meibomian gland atrophy in a pediatric population. (optiksoptometry.ca)
  • 2020). Meibomian Gland Dropout, not Distortion, Can Distinguish Dry Eyes from Normal Eyes in Contact Lens Wearers. (eyeresearchnow.com)
  • In humans, more than 90 different proteins have been identified in meibomian gland secretions. (wikipedia.org)
  • This condition occurs when the oil glands become blocked with thick secretions. (optometrists.org)
  • It is characterised by obstruction of the Meibomian glands and/or alterations in the consistency of glandular secretions. (physiciansweekly.com)
  • Poor secretions should be treated by lid hygiene and massaged with a moist cotton tip in order to remove debris from the eye and increase blood flow so as to open up occluded meibomian glands. (wildpartyofficial.com)
  • This is why I say it's much more common to have Meibomian Gland Dysfunction than not, and even if you've been diagnosed with Sjogrens, the newer interventional dry eye treatments may still be helpful to you. (drmelaniedenton.com)
  • Other treatments include heating and massaging the glands, oral medication, prescription eye drops, and intense pulsed light (IPL). (harreleyecare.com)
  • Other treatments for MGD include Radiofrequency to adequately heat the glands in order to allow the clogged oil to be expressed. (eyes360.ca)
  • Although many of us believe that our tears come from one place- the lacrimal gland and that they're fairly simple - just "water" - that could not be further from the truth. (drmelaniedenton.com)
  • In reality, your tears are produced from the goblet cells on the conjunctiva, the lacrimal gland as well as the meibomian glands and there's other accessory glands that produce tears as well. (drmelaniedenton.com)
  • The lacrimal glands produce the watery layer, while the conjunctiva produces the mucus layer. (ea-ny.com)
  • People with dry eye syndrome have a problem with the lacrimal glands, where they fail to produce enough tears. (ea-ny.com)
  • Radiation therapy to treat head and neck cancers, cancer of the eye socket or whole brain radiation for brain cancer, often damages the lacrimal glands. (neweraeyecare.com)
  • Meibomian gland dysfunction is a leading cause of ocular surface disease. (illinois.edu)
  • Heating the eyelid margin will increase oil production and melt the "crusty" oil that has become solid in the glands. (wildpartyofficial.com)
  • Meibomian cysts or tumors occur on or under the eyelid margin. (hugspetproducts.com)
  • Meibomian glands (also called tarsal glands, palpebral glands, and tarsoconjunctival glands) are sebaceous glands along the rims of the eyelid inside the tarsal plate. (wikipedia.org)
  • The condition is caused by obstruction of one of the ducts that drains one of the Meibomian glands. (furrycritter.com)
  • In meibomian gland dysfunction, the lipid composition is abnormal, and gland ducts and orifices become inspissated with hard, waxy plugs. (msdmanuals.com)
  • However, little is known about the regulatory processes that control the development and maintenance of this sebaceous gland. (illinois.edu)
  • In a recent study, 42% of kids aged 4 to 17 years showed some evidence of Meibomian gland atrophy. (optiksoptometry.ca)
  • When we take a look at his meibomian gland atrophy. (drmelaniedenton.com)
  • Dysfunctional meibomian glands is believed to be the most often cause of dry eyes. (wikipedia.org)
  • Dysfunctional meibomian glands often cause dry eyes, one of the more common eye conditions. (wikipedia.org)
  • However, if these glands become blocked or dysfunctional, it can lead to meibomian gland dysfunction (MGD). (pacificpieroptometry.com)
  • These glands become dysfunctional if blocked, leading to swelling within or on the margins of the eyelid. (hugspetproducts.com)
  • After examining the meibomian glands you find, in addition to the keratinization, a severe dropout of the lower lid glands (Figure #4). (nulids.com)
  • Meibomian gland dropout can differentiate, in contact lens-wearers, those who have dry eye disease. (eyeresearchnow.com)
  • Some of the main changes observed in Meibomian glands (MG) include distortion (bending of the secretory duct) and dropout (gland destruction). (eyeresearchnow.com)
  • Hence, it comes as no surprise that there was no significant difference found in estradiol levels and testosterone levels for dry eye of meibomian gland assessment apart from that seen between severe and mild meibomian gland dropout cases and increased testosterone levels. (uk.com)
  • A chalazion is caused by a blocked duct in one of the meibomian glands. (medlineplus.gov)
  • A chalazion is caused by noninfectious meibomian gland occlusion, whereas a hordeolum usually is caused by infection. (msdmanuals.com)
  • People who suffer from MGD have blocked glands that fail to secrete enough oil. (ea-ny.com)
  • Injection of Platelet Rich Plasma into the Meibomian Gland Seems to Improve Meibomian Gland Structure and Potentially Function: Case of 1. (drcremers.com)
  • We are trying to figure out if we can inject IGF-1 (Insulin Growth Factor 1) into the meibomian glands to make them grow back better than Platelet Rich Plasma. (drcremers.com)
  • MGD occurs when the Meibomian glands become blocked or damaged. (laservue.com)
  • Dry eye often occurs as a result of the Meibomian gland becoming blocked. (shippeefamilyeyecare.com)
  • Just like the dry-eye syndrome, the meibomian gland dysfunction occurs due to the aging process. (eyemantra.org)
  • Because severe meibomian gland dysfunction can alter the lid margin structure, confounding efforts to assess outcomes, only patients with moderate dysfunction were included in the analysis, Dr Jain explained. (medscape.com)
  • Unfortunately, these drops tend to provide only transient relief, because, without an adequate layer of Meibomian Gland oil, the liquid from the drops simply evaporate off of the eye. (midwesteyeassociates.com)
  • In MGD, the quantity or quality of oil the meibomian glands secrete into tears is deficient, causing tears to evaporate too quickly. (uab.edu)
  • We hypothesized that the mechanism underlying this effect is the inhibition of IGF-1 action in epithelial cells of the meibomian gland. (drcremers.com)
  • Application of IGF-1 and growth hormone to human meibomian gland epithelial cells. (drcremers.com)
  • https://www.researchgate.net/publication/261757494_The_Effects_of_Insulin-like_Growth_Factor_1_and_Growth_Hormone_on_Human_Meibomian_Gland_Epithelial_Cells [accessed Oct 02 2018]. (drcremers.com)
  • We hypothesize that this diabetic impact is due, at least in part, to the effects of insulin resistance/deficiency and hyperglycemia on human meibomian gland epithelial cells (HMGECs). (drcremers.com)
  • Association between very long chain fatty acids in the meibomian gland and dry eye resulting from n-3 fatty acid deficiency. (bvsalud.org)
  • Meibomian gland dysfunction is more often seen in women and is regarded as the main cause of dry eye disease. (wikipedia.org)
  • So why do I claim that Dry Eye Disease IS Meibomian Gland Dysfunction? (drmelaniedenton.com)
  • Clinically, Meibomian Gland Dysfunction is super prevalent, and even my patients with Sjogrens syndrome or other autoimmune disease, which you might think would cause a purely aqueous deficient situation, do indeed have Meibomian Gland Dysfunction present. (drmelaniedenton.com)
  • Overall, 86% of these qualified Dry Eye Disease patients demonstrated signs of Meibomian Gland Dysfunction. (drmelaniedenton.com)
  • Between previous studies showing BPH as a risk factor for dry eye disease (DED), meibomian gland dysfunction (MGD) being the most common cause of DED and sex hormones playing a role in MGD, researchers decided to examine the characteristics of meibomian glands in individuals with BPH with the use of noncontact meibography. (reviewofoptometry.com)
  • The National Eye Institute, part of the National Institutes of Health, awarded Jason J. Nichols, OD, MPH, PhD, FAAO, a five-year, $1.9 million R01 grant to study potential molecular markers in meibomian gland dysfunction, a type of evaporative dry eye disease. (uab.edu)
  • Evaporative dry eye is the most common type of dry eye disease, and meibomian gland dysfunction is the most widespread form of evaporative dry eye. (uab.edu)
  • ASLMS 2023 IPL-RF Combination Effective for Dry Eyes in Small Study The study evaluated the effects of intense pulsed light with topical radiofrequency in 11 patients with dry eye disease related to meibomian gland dysfunction. (medscape.com)
  • The only objective outcome in the meibomian gland assessments was lipid layer thickness. (uk.com)
  • the lash follicles and the meibomian glands are also involved. (msdmanuals.com)
  • Autoimmune diseases like Sjögren's syndrome or lupus can also cause meibomian gland dysfunction. (pacificpieroptometry.com)
  • What Are Treatment Options for Loss of Zeis, Moll and Meibomian Glands Due to Stevens-Johnson Syndrome/TEN? (eyedocnews.com)
  • One Response to "What Are Treatment Options for Loss of Zeis, Moll and Meibomian Glands Due to Stevens-Johnson Syndrome/TEN? (eyedocnews.com)
  • The only difference between the two is that the dry eye syndrome is caused due to the lack of tears whereas the meibomian gland dysfunction is caused due to the lack of oil secretion into the tears. (eyemantra.org)
  • Both dry eye syndrome and meibomian gland dysfunction can be treated effectively. (ea-ny.com)
  • Dysfunction of the Meibomian glands is a frequent occurrence in dry eye syndrome. (eyeresearchnow.com)
  • A blocked meibomian gland can cause a chalazion (or "meibomian cyst") to form in the eyelid. (wikipedia.org)
  • A non-neoplastic cyst of the MEIBOMIAN GLANDS of the eyelid. (bvsalud.org)
  • Restoring function back to your glands can restore the natural balance and proper biological makeup of your tears so they can function as they should. (laservue.com)
  • The function of these glands is to secrete oils onto the surface of the eye which help to keep the tears from evaporating too quickly, causing dry eyes. (drarunghosh.co.uk)
  • Because young patients will rely on their Meibomian glands for perhaps another 70 years, we need to treat aggressively and do all we can to preserve the anatomy and restore function. (optiksoptometry.ca)
  • It also stimulates collagen production to help with gland function and health. (optiksoptometry.ca)
  • Less frequent blinking results in dryer eyes, which can harm the long-term ability of your meibomian glands to function properly. (midwesteyeassociates.com)
  • Age and contact lens use can also affect the function of the glands. (ea-ny.com)
  • People have the same glands that form the same function. (hugspetproducts.com)
  • Meibomian gland function is evaluated by observing the glands through a slit lamp while pressure is applied, simulating the pressure of a deliberate blink. (notadryeye.org)
  • Together, our data provide evidence showing that gelatinolytic activity in meibocytes is dependent on CD147, and supports a role for CD147 in maintaining the normal development and function of the meibomian gland. (illinois.edu)
  • Activities that reduce our blink rate such as computer and phone use, watching TV and long periods of driving can reduce the function of the meibomian glands. (eyes360.ca)
  • Omega 3s in our diet are important to ensure gland function and secretion of good quality oil. (eyes360.ca)
  • To test the hypothesis that IGF-1 stimulates meibomian gland function in vitro and to examine whether growth hormone, a closely related hormone of IGF-1, has the same effect. (drcremers.com)
  • Intense pulsed light for the treatment of Meibomian gland dysfunction: A systematic review and meta-analysis. (physiciansweekly.com)
  • If you have reason to believe an insurance company will not pay for a particular service (such as an in-office meibomian gland heating treatment), have the patient sign a Waiver of Liability (also known as Advanced Beneficiary Notice, or ABN, specifically for Medicare). (reviewob.com)
  • Because of careful patient selection, this study provides strong evidence that omega-3 fatty acids are effective in the treatment of meibomian gland dysfunction, said Dr Jain. (medscape.com)
  • We have in-office therapies such as the TempSure radiofrequency treatment which heats the blocked up oil glands to allows the oil to flow more freely. (optiksoptometry.ca)
  • This post will give you a better understanding of what benign meibomian gland cysts in dogs are, when surgery is recommended, what surgery involves, and post-treatment recovery. (hugspetproducts.com)
  • There are a few ways a veterinarian could approach the treatment of benign meibomian gland cysts in dogs. (hugspetproducts.com)
  • One is LipiFlow® thermal pulsation therapy that can eliminate gland blockages. (ea-ny.com)
  • The glands do not have direct contact with eyelash follicles. (wikipedia.org)
  • posterior to the lashes are the openings of the meibomian glands of the tarsal plate. (medscape.com)
  • They may also use a special device called a meibomian gland evaluator to measure the amount of oil produced by the glands. (healthyorbust.org)
  • Blinking applies pressure to the glands allowing them to secrete the oil. (eyes360.ca)
  • Clogged meibomian glands can be quite a nuisance, causing dry, irritated eyes. (pacificpieroptometry.com)
  • If you've ever experienced dry, burning, or irritated eyes, it's possible that clogged meibomian glands are the cause. (pacificpieroptometry.com)
  • Unfortunately, we can't cure dry eyes, but we do have good therapies that can help to keep these Meibomian glands healthy and keep our eyes comfortable. (optiksoptometry.ca)
  • Because of this, his zeis, moll and meibomian glands have burnt up and he no longer has lubrication in his eyes. (eyedocnews.com)
  • Due to the unusual blockage in one of the glands inside the eye, the eyes tend to become red. (eyemantra.org)
  • If your eyes itch, burn, sting, look red, or you have a constant feeling of something being lodged in your eye, you may have a condition called Meibomian ("my-BOH-mee-an") Gland Dysfunction, or MGD. (midwesteyeassociates.com)
  • When these glands become blocked or inflamed, it can lead to dry eyes, irritation, and discomfort. (healthyorbust.org)
  • If these glands become blocked, the eyes can become dry and irritated. (healthyorbust.org)
  • Meibomian gland dysfunction (MGD) is a common eye condition that affects the glands responsible for producing the oils that keep the eyes lubricated. (healthyorbust.org)
  • This means that your eyes will not be lubricated by free-flowing oil, and it also means that the oil your glands are producing is not optimal. (eyelovethesun.com)
  • After you've heated the oil in your glands, you'll want to release it onto your eyes. (eyelovethesun.com)
  • When these glands are blocked or develop abnormally, tears produced by the eyes will not contain enough of the oil needed to maintain moisture. (medicalnewstoday.com)