*  CIENCIASMEDICASNEWS: Search | National Guideline Clearinghouse: "Male Urogenital Diseases"

KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease.. Kidney Disease: Improving ... Kidney disease in HIV-infected patients.. New York State Department of Health ... Search , National Guideline Clearinghouse: "Male Urogenital Diseases" Search , National Guideline Clearinghouse. "Male ...
https://elbiruniblogspotcom.blogspot.com.ar/2017/03/search-national-guideline-clearinghouse_65.html

*  Study of Antioxidants on Prostate Tumors in Men Undergoing Radical Prostatectomy for Prostate Cancer - Full Text View -...

Genital Neoplasms, Male. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. Genital Diseases, Male. Prostatic Diseases. ...
https://clinicaltrials.gov/ct2/show/NCT00844792

*  Efficacy,Safety and Quality of Life After TOOKAD® Soluble VTP for Localized Prostate Cancer - Full Text View - ClinicalTrials...

Prostatic Disease. Genital Neoplasm,male. Urogenital neoplasm. Genital disease,male. Male urogenital disease. Neoplasms. ... Genital Neoplasms, Male. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. Genital Diseases, Male. Prostatic Diseases. ... Any condition or history of active rectal inflammatory bowel disease or other factors which may increase the risk of fistula ...
https://clinicaltrials.gov/ct2/show/NCT01875393?recr=Open&cond="Genital Diseases, Male"&rank=4

*  Lab Members > Yarbrough Laboratory for Head and Neck Oncology | Yale Cancer Center | Yale School of...

Autoimmune Diseases; Male Urogenital Diseases; Otorhinolaryngologic Diseases; Surgical Procedures, Operative; Therapeutics View ... Wendell Yarbrough, MD, MMHC is the Section Chief of Otolaryngology Department of Surgery, Director of the Head & Neck Disease ...
medicine.yale.edu/lab/yarbrough/members/index.aspx

*  Guoping Cai, MD > Pathology | Yale School of...

Lung Neoplasms; Pancreas; Male Urogenital Diseases Research Organizations. Pathology: Thoracic and Genitourinary Translational ...
medicine.yale.edu/pathology/education/graduateprogram/guoping_cai-2.profile

*  New Descriptors by Tree Subcategory - 2015

C12 (Male Urogenital Diseases). Atypical Hemolytic Uremic Syndrome. C13 (Female Urogenital Diseases and Pregnancy Complications ... C10 (Nervous System Diseases). Allesthesia. Benign Paroxysmal Positional Vertigo. Cerebrospinal Fluid Leak. Hemimegalencephaly ... C16 (Congenital, Hereditary, and Neonatal Diseases and Abnormalities). Congenital Microtia. Hemimegalencephaly. Hernias, ...
https://nlm.nih.gov/mesh/newbysub.html

*  Doctors <span class="caret"></span>

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Neoplasms; Pathological Conditions, ... Genital Diseases, Male; Kidney Diseases; Prostatic Neoplasms; Ureteral Diseases; Urethral Diseases; Urinary Bladder Diseases; ... Cystitis, Interstitial; Female Urogenital Diseases; Nitric Oxide Synthase; Prostate; Prostatic Hyperplasia; Urinary Bladder, ... Endocrinology; Erectile Dysfunction; Genitalia, Male; Men's Health; Prostatic Diseases; Prostatic Hyperplasia; Reproductive ...
urology.med.yale.edu/doctors/index.aspx

*  "Case records of the Massachusetts General Hospital. Case 31-2005. A 60" by Jonathan Kay and Robert T. McCluskey

Male Urogenital Diseases Commons, Rheumatology Commons, Skin and Connective Tissue Diseases Commons ... Male; Middle Aged; Prednisone; Renal Insufficiency; Rocky Mountain Spotted Fever; Skin; Vasculitis ...
escholarship.umassmed.edu/rheumatology_pubs/142/

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The use of a model that mimics the condition of lung diseases in humans is critical for studying the pathophysiology and/or ... Depending on the goal of the research, large animals as models of pulmonary disease often resemble the situation of the human ... Human bronchial epithelial cells are needed for cell models of disease and to investigate the effect of excipients and ...
https://jove.com/visualize/abstract/19582164/il-12-can-target-human-lung-adenocarcinoma-cells-normal-bronchial

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... Autoimmune Diseases, Bacterial Infections and Mycoses, Male Urogenital Diseases, Bacterial pathogenesis, pain, autoimmunity, ... Disease Models, Animal, Cell Differentiation, Urogenital System, Prostate, Urogenital Sinus, Mesenchyme, Stem Cells, animal ... There is a major increase in the awareness of the positive impact of exercise on improving several disease states with ...
https://jove.com/visualize/abstract/26147849/changes-estrogen-receptor-er-esr2-expression-without-changes

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... Individuals with inflammatory bowel disease (IBD), such as Crohn's disease (CD) or ulcerative colitis (UC) are at increased ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... Inflammatory Bowel Diseases, Infectious colitis, Inflammatory Bowel Disease, colitis, hyperplasia, immunostaining, epithelial ...
https://jove.com/visualize/abstract/23555575/targeted-deletion-metastasis-associated-phosphatase-ptp4a3-prl-3

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... Autoimmune Diseases, Bacterial Infections and Mycoses, Male Urogenital Diseases, Bacterial pathogenesis, pain, autoimmunity, ... Disease Models, Animal, Cell Differentiation, Urogenital System, Prostate, Urogenital Sinus, Mesenchyme, Stem Cells, animal ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ...
https://jove.com/visualize/abstract/26024527/cell-kinetic-studies-fail-to-identify-sequentially-proliferating

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... Disease Models, Animal, Cell Differentiation, Urogenital System, Prostate, Urogenital Sinus, Mesenchyme, Stem Cells, animal ... one experimental male and one cross-mating reference male. The same mating scheme is then followed using other experimental ... Spermatozoa are male reproductive cells especially designed to reach, recognize and fuse with the egg. To perform these tasks, ...
https://jove.com/visualize/abstract/25803277/restoration-spermatogenesis-male-fertility-using-an-androgen-receptor

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... This protocol describes the key steps to develop RCC disease progression stages similar to patients. First, it uses a highly ... This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop ...
https://jove.com/visualize/abstract/22984407/anti-tumor-effects-peptide-tmtp1-gg-d-klaklak-2-on-highly-metastatic

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... Moreover, these solitary cells has been shown to disseminate from the primary tumor at an early stage of disease progression 8- ... This protocol describes the key steps to develop RCC disease progression stages similar to patients. First, it uses a highly ...
https://jove.com/visualize/abstract/22348125/the-tumor-log-odds-positive-lymph-nodes-metastasis-staging-system

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... Many useful animal models exist to study breast cancer, but none completely recapitulate the disease progression that occurs in ... NIRF imaging showed dramatic changes in lymphatic architecture and function with human disease. It remains unclear how these ...
https://jove.com/visualize/abstract/22087309/lymphangiogenesis-regional-lymph-nodes-is-an-independent-prognostic

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... and progesterone differently than the male brain. Furthermore, neonate male and female rodents respond differently to ischemic ... Graft-versus-host disease (GVHD) is the limiting barrier to the broad use of bone marrow transplant as a curative therapy for a ... Visualising androgen receptor activity in male and female mice. D Alwyn Dart, Jonathan Waxman, Eric O Aboagye, Charlotte L ...
https://jove.com/visualize/abstract/23940781/visualising-androgen-receptor-activity-in-male-and-female-mice

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... and progesterone differently than the male brain. Furthermore, neonate male and female rodents respond differently to ischemic ... Using this method, the Herson Lab has demonstrated a male-specific role for the ion channel TRPM2 in ischemic cell death. In ... Custom rectangular implants are placed bilaterally in the distal femora of male Wistar rats and collected with the surrounding ...
https://jove.com/visualize/abstract/23940550/testosterone-delivered-with-scaffold-is-as-effective-as-bone

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... CTC count can be used to follow disease progression based on the correlation between CTC concentration in blood and disease ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... How antibodies cause disease is an area of ongoing investigation, and data suggests that interactions between antibodies and ...
https://jove.com/visualize/abstract/22363532/circulating-antinuclear-antibodies-patients-with-pelvic-masses-are

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The challenge in monitoring intra-peritoneal (i.p.) disease limits the use of i.p. models and thus most xenografts are ... This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop ... Many useful animal models exist to study breast cancer, but none completely recapitulate the disease progression that occurs in ...
https://jove.com/visualize/abstract/24260587/novel-immunocytokine-il12-ss1-fv-inhibits-mesothelioma-tumor-growth

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... Spermatozoa are male reproductive cells especially designed to reach, recognize and fuse with the egg. To perform these tasks, ... The protective effect of many HLA class I alleles on HIV-1 pathogenesis and disease progression is, in part, attributed to ... Infectious Diseases, Issue 90, HIV-1, Gag, viral replication, replication capacity, viral fitness, MJ4, CEM, GXR25 ...
https://jove.com/visualize/abstract/24709990/small-theropod-teeth-from-late-cretaceous-san-juan-basin-northwestern

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... glioma 2), local invasion into surrounding healthy tissue is the root cause of disease and death. For other cancers (e.g. ... Whilst stage I tumors have 5-year survival rates ,85%, survival rates for stage III/IV disease are ,40%. Thus, the high rates ...
https://jove.com/visualize/abstract/24505346/paradoxical-roles-mineral-dust-induced-gene-on-cell-proliferation

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Medicine, Issue 79, Urogenital System, Male Urogenital Diseases, Surgical Procedures, Operative, Life Sciences (General), ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... and coronary heart disease, and provides potential new leads for therapeutic targets to those diseases. The descriptive text of ... Immune System Diseases, Respiratory Tract Diseases, Natural Science Disciplines, Life Sciences (General), transfection, lung, ...
https://jove.com/visualize/abstract/22514692/ms4a1-dysregulation-asbestos-related-lung-squamous-cell-carcinoma-is

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Autoimmune Diseases, Bacterial Infections and Mycoses, Male Urogenital Diseases, Bacterial pathogenesis, pain, autoimmunity, ... The majority of cancer-related deaths occur subsequent to the development of metastatic disease. This highly lethal disease ... More than 32,000 patients are diagnosed with pancreatic cancer in the United States per year and the disease is associated with ... We utilized a previously described intraurethral infection method6 to deliver a clinical strain of UPEC into male mice thereby ...
https://jove.com/visualize/abstract/19484134/complement-c1q-activates-tumor-suppressor-wwox-to-induce-apoptosis

*  HYDROCHLOROTHIAZIDE - hydrochlorothiazide capsule - Prescription (RX) Marketed Drugs Encyclopedia

Renal Disease. Cumulative effects of the thiazides may develop in patients with impaired renal function. In such patients, ... Urogenital: Impotence.. Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy ... or in male and female rats (at doses of approximately 100 mg/kg/day). The NTP, however, found equivocal evidence for ... Parathyroid Disease. Calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with ...
drugsdb.eu/drug.php?d=Hydrochlorothiazide&m=Udl Laboratories, Inc.&id=180451dd-0323-4810-843c-255c2ff9fbcb.xml


(1/155) Cohort study of art glass workers in Tuscany, Italy: mortality from non-malignant diseases.

This investigation studies cause-specific mortality of art glass workers employed in 17 industrial facilities in Tuscany, Italy. A cohort of 3,390 workers employed for at least 1 year was enumerated from company payrolls. Follow-up was between the start of employment in each factory and 31 December 1993. The cause-specific expected mortality was computed relative to Tuscany rates and specified for gender, 5-year age groups and calendar year. Separate analyses were carried out for the jobs of makers and formers and for batch mixers. Among males (3, 180 individuals) observed mortality for non-cancer causes was higher than expected for hypertensive disease [standardized mortality ratio (SMR) = 178, 90% confidence interval (90% CI) = 96-301], pneumoconiosis (SMR = 200, 90% CI = 94-376) and diseases of the genitourinary system (SMR = 169, 90% CI = 95-279). Increases for the above causes were shown also among makers and formers: hypertensive disease (SMR = 182, 90% CI = 85-341), pneumoconiosis (SMR = 250, 90% CI = 109-493) and diseases of the genitourinary system (SMR = 224, 90% CI = 121-380). For batch mixers an increase was present for cerebrovascular disease. The observed mortality for cancer causes was above the expected for cancers of the larynx, lung, stomach and brain. This study points to the existence for Tuscan glass workers of health effects in addition to cancer; previously observed carcinogenic effects were also confirmed.  (+info)

(2/155) Induction of HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections.

HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein (MOMP) of Chlamydia trachomatis are present in the peripheral blood of humans who acquired genital tract infections with the organism. Three HLA-A2-restricted epitopes and two HLA-B51-restricted epitopes were identified in serovar E-MOMP. One of the five epitopes spans a variable segment of MOMP and is likely a serovar E-specific epitope. The other four epitopes are localized in constant segments and are C. trachomatis species specific. CTL populations specific for one or more of the four constant segment epitopes were isolated from all 10 infected subjects tested, regardless of infecting serovars, but from only one of seven uninfected subjects tested. The CTLs failed to recognize corresponding peptides derived from Chlamydia pneumoniae MOMP, further suggesting that they indeed resulted from genital tract infections with C. trachomatis. Significantly, ME180 human cervical epithelial cells productively infected with C. trachomatis were killed by the MOMP peptide-specific CTLs. Further investigations of the ability of such CTLs to lyse normal infected epithelial cells and their presence at inflamed sites in the genital tract will help understand the protective or pathological role of CTLs in chlamydial infections. The MOMP CTL epitopes may be explored as potential components of a subunit vaccine against sexually transmitted diseases caused by C. trachomatis. Moreover, the knowledge provided here will facilitate studies of HLA class I pathways of chlamydial Ag processing and presentation in physiologically relevant human APCs.  (+info)

(3/155) Mortality from nonmalignant diseases of the respiratory, genitourinary and nervous systems among workers exposed to styrene in the reinforced plastics and composites industry in the United States.

OBJECTIVES: Mortality from diseases of the nervous system and nonmalignant diseases of the respiratory and genitourinary systems was examined for workers exposed to styrene. METHODS: Altogether 15,826 styrene-exposed workers in 30 plants in the reinforced plastics and composites industry were included. Vital status was ascertained through 31 December 1989. Individual exposure estimates were developed based on job functions, existing industrial hygiene data, process changes, engineering controls, work practices, and the use of personal protective equipment. Analyses were based on cause-specific standardized mortality ratios (SMR) and the Cox proportional hazards model. Mortality data were analyzed by latency, duration of exposure, average exposure, cumulative exposure, and process category. RESULTS: For diseases of the nervous system, the SMR was 0.56 [95% confidence interval (95% CI) 0.31-0.95]. Mortality from nonmalignant genitourinary diseases was not increased (SMR 0.87, 95% CI 0.46-1.50). Latency, duration of exposure, average exposure, cumulative exposure, and process category showed no association between styrene exposure and these 2 types of disease. A small increase in mortality from nonmalignant respiratory diseases was found (SMR 1.21, 95% CI 0.98-1.47), mainly due to "other nonmalignant respiratory diseases" (SMR 1.40, 95% CI 1.04-1.84). The highest increase occurred for short exposure duration (SMR 1.79 for <1 year's exposure) or low exposure (SMR 2.15 for <10 ppm-years); there were no increased risks in the high exposure categories. The Cox proportional hazard model revealed no association between styrene exposure and the diseases. CONCLUSIONS: No relationship was found between mortality from any of the diseases examined and any of the styrene exposure indices. The findings were compared with those reported in a European study of styrene-exposed workers.  (+info)

(4/155) Creatinine at the evaluation of urinary 1-methyladenosine and pseudouridine excretion.

The elevation of urinary modified nucleosides levels in urine is found in patients with cancers. In the present study, we have tested 616 urine samples randomly collected from non-malignant cases. Thirty-two percent (194/616) and 11% (68/616) had elevated levels of 1-methyladenosine and pseudouridine, respectively (They are designated as false-positive cases). To elucidate the cause on non-specific elevation of the nucleosides, the correlation between creatinine excretion level and urinary nucleosides levels were determined. The result revealed that false-positive cases were frequently detected in patients with lower creatinine excretion levels. The mean creatinine levels of false-positive cases were significantly lower than those of negative cases. From these results, the false-positive of urinary 1-methyladenosine and pseudouridine might be due to the low creatinine excretion mainly caused by the renal dysfunction. Creatinine excretion in each individual should be taken into consideration in case of determining urinary modified nucleosides.  (+info)

(5/155) Etiology of genital ulcer disease in Dakar, Senegal, and comparison of PCR and serologic assays for detection of Haemophilus ducreyi.

We used PCR assays to determine the etiology of genital ulcers in patients presenting to a sexually transmitted disease clinic in Dakar, Senegal, and evaluated the ability of two PCR tests (groEL and recD) and two serological tests (adsorption enzyme immunoassay [EIA] and lipooligosaccharide [LOS] EIA) to detect current Haemophilus ducreyi infection. We found that in this population, H. ducreyi, T. pallidum, and herpes simplex virus HSV DNA were detected in 56, 15, and 13% of 39 genital ulcer specimens, respectively, and H. ducreyi DNA was detected in 60% (3 of 5) of samples from ulcerated bubos. Among 40 consecutive patients with genital ulcer disease and with sufficient sample for both PCR assays, the recD and groEL H. ducreyi PCR assays were 83% concordant, with the recD PCR assay detecting six (15%) additional positive specimens and the groEL assay detecting one (3%) additional positive specimen. Compared to PCR, the adsorption EIA and LOS EIA tests had sensitivities of 71 and 59% and specificities of 57 and 90%, respectively, for the diagnosis of current H. ducreyi infection. While these differences in specificity could be due either to previous infection with H. ducreyi or to the detection of cross-reacting antibodies, only 6% of patients from a nearby family planning clinic gave a positive reaction in both the adsorption EIA and LOS EIA assays, indicating that cross-reacting antibodies are not prevalent among clinic attendees in this city. Our studies indicate that the adsorption EIA detects both current and past infection, while the LOS EIA assay is more specific for current infection with H. ducreyi in this population.  (+info)

(6/155) Results of a phase II study using estramustine phosphate and vinblastine in combination with high-dose three-dimensional conformal radiotherapy for patients with locally advanced prostate cancer.

PURPOSE: To assess the feasibility and tolerance of neoadjuvant and concomitant estramustine phosphate and vinblastine (EV) with high-dose three-dimensional conformal radiotherapy (3D-CRT) for patients with unfavorable-risk prostate cancer. PATIENTS AND METHODS: Twenty-seven patients with unfavorable-risk prostate cancer were enrolled onto a prospective study to determine the feasibility of combining EV with 3D-CRT. Patients were eligible if any of the following requirements were satisfied: (1) Gleason score > or =8 and prostate-specific antigen (PSA) > 10 ng/mL; (2) Gleason score of 7 and PSA > 20 ng/mL; (3) clinical stage T3N0M0 disease with PSA > 20 ng/mL; (4) any patient with T4N0M0 disease; or (5) patients with TXN1MO disease. Therapy consisted of three 8-week cycles of EV and 8 weeks of 3D-CRT. Estramustine phosphate was given orally beginning on week 1 and continued until the completion of 3D-CRT. Each 8-week cycle of vinblastine consisted of 6 weekly intravenous injections followed by a 2-week rest period. Radiation therapy was administered using a three-dimensional conformal approach to a prescription dose of 75.6 Gy. The median follow-up was 26 months (range, 6 to 40 months). RESULTS: Twenty-three (85%) of 27 patients completed the entire course of therapy and were assessable for toxicities and biochemical outcome. Two patients (7%) developed grade 3 hematologic toxicity that resolved, and two patients (7%) developed grade 3 hepatoxicity, manifesting as persistent elevation of serum transaminase levels, necessitating discontinuation of the chemotherapy and withdrawal from the treatment program. The most prominent adverse effects from this regimen were mild to moderate (grade 1 to 2) nausea and fatigue related to estramustine. Mild peripheral edema was seen in 15% of patients and was treated with diuresis. 3D-CRT was tolerated well in these patients. Medications were required for relief of acute grade 2 rectal (gastrointestinal [GI]) and urinary (genitourinary [GU]) symptoms in 35% and 48% of patients, respectively. Three patients developed acute grade 3 GU toxicities. The 2-year actuarial likelihood of late grade 2 GI toxicity was 20%. No late grade 3 or 4 GI toxicities were observed. The 2-year actuarial likelihoods of late grade 2 and 3 GU toxicities were 25% and 12%, respectively. No grade 4 GU toxicity was observed. CONCLUSION: Neoadjuvant and concomitant EV with high-dose 3D-CRT is well tolerated in patients with unfavorable-risk prostate cancer. Although the incidence of modest (grade 2) late GI and GU toxicities seem to be increased compared with 3D-CRT alone or in combination with androgen ablation therapy, no severe toxicities were encountered with this regimen.  (+info)

(7/155) Detection of Chlamydia trachomatis-specific antibodies in human sera by recombinant major outer-membrane protein polyantigens.

This study was performed to generate and evaluate recombinant antigens for use in a species-specific Chlamydia trachomatis immunoassay. In a molecular genetic approach, fragments of the C. trachomatis major outer-membrane protein (MOMP) were produced as fusion proteins to create three different constructs encompassing the variable domains I, II and IV of selected C. trachomatis serovars. The recombinant MOMP polyantigens were affinity-purified and used in an enzyme-linked immunosorbent assay. Antibody detection was evaluated with 103 patient sera and the results were compared with titres obtained in the micro-immunofluorescence test. The results showed that the generated MOMP polyantigens detected the presence of C. trachomatis-specific human antibodies with little cross-reaction to C. pneumoniae-specific antibodies. When compared to the micro-immunofluorescence assay the MOMP polyantigen detected the presence of anti-C. trachomatis IgG antibodies with a sensitivity of 80% and a specificity of 91%.  (+info)

(8/155) Urogenital Chlamydia trachomatis serovars in men and women with a symptomatic or asymptomatic infection: an association with clinical manifestations?

To determine whether certain Chlamydia trachomatis serovars are preferentially associated with a symptomatic or an asymptomatic course of infection, C. trachomatis serovar distributions were analyzed in symptomatically and asymptomatically infected persons. Furthermore, a possible association between C. trachomatis serovars and specific clinical symptoms was investigated. C. trachomatis-positive urine specimens from 219 asymptomatically infected men and women were obtained from population-based screening programs in Amsterdam. Two hundred twenty-one C. trachomatis-positive cervical and urethral swabs from symptomatically and asymptomatically infected men and women were obtained from several hospital-based departments. Serovars were determined using PCR-based genotyping, i.e., restriction fragment length polymorphism analysis of the nested-PCR-amplified omp1 gene. The most prevalent C. trachomatis serovars, D, E, and F, showed no association with either a symptomatic or asymptomatic course of infection. The most prominent differences found were (i) the association of serovar Ga with symptoms in men (P = 0.0027), specifically, dysuria (P < 0.0001), and (ii) detection of serovar Ia more often in asymptomatically infected people (men and women) (P = 0.035). Furthermore, in women, serovar K was associated with vaginal discharge (P = 0.002) and serovar variants were found only in women (P = 0.045).  (+info)



Prostatic Diseases


  • These findings greatly enhance our understanding of the mechanisms regulating prostate epithelial cell renewal and may have significant implications in defining the cell of origin of proliferative prostatic diseases. (jove.com)

prostate


  • New therapies for two common prostate diseases, prostate cancer (PrCa) and benign prostatic hyperplasia (BPH), depend critically on experiments evaluating their hormonal regulation. (jove.com)
  • Androgens signal through the androgen receptor (AR) to regulate male secondary sexual characteristics, reproductive tract development, prostate function, sperm production, bone and muscle mass as well as body hair growth among other functions. (jove.com)
  • Progress in prostate cancer research is severely limited by the availability of human-derived and hormone-naïve model systems, which limit our ability to understand genetic and molecular events underlying prostate disease initiation. (jove.com)
  • Toward developing better model systems for studying human prostate carcinogenesis, we and others have taken advantage of the unique pro-prostatic inductive potential of embryonic rodent prostate stroma, termed urogenital sinus mesenchyme (UGSM). (jove.com)

pathogenesis


  • Mouse models are widely used to study pathogenesis of human diseases and to evaluate diagnostic procedures as well as therapeutic interventions preclinically. (jove.com)
  • Importantly, antibodies have been implicated in the pathogenesis of a number of human diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), paraneoplastic syndromes, multiple sclerosis (MS) and human T-lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) 1-9 . (jove.com)
  • Thus, a procedure that allows for the study of intracellular antibody:protein interactions would lend great insight into disease pathogenesis. (jove.com)

systemic


  • Typical tumor implantation models utilize ectopic or orthotopic primary tumor implantation, but few include systemic spontaneous metastatic disease that mimics the clinical setting. (jove.com)
  • Finally, it outlines the steps necessary to monitor and assess micro-and macro-metastatic disease progression, including bioluminescent imaging as well provides a detailed visual necropsy guide to score systemic disease distribution. (jove.com)

Kidney


  • KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease. (blogspot.com.ar)
  • Management of chronic kidney disease. (blogspot.com.ar)
  • Kidney disease in HIV-infected patients. (blogspot.com.ar)

therapeutic


  • These results provide the first definitive evidence implicating Ptp4a3 in colon tumorigenesis and highlight the potential value of the phosphatase as a therapeutic target for early stage malignant disease. (jove.com)
  • Such observations underscore the functional importance of precisely regulating dendritic morphology, and suggest that identifying mechanisms that control dendritic growth will not only advance understanding of how neuronal connectivity is regulated during normal development, but may also provide insight on novel therapeutic strategies for diverse neurological diseases. (jove.com)

Human


  • This model induces tumors with histological and molecular changes closely resembling those occurring in human CAC and provides a highly valuable model for the study of oncogenesis and chemoprevention in this disease. (jove.com)

cell


  • One of the key challenges to improved testing of new experimental therapeutics in renal cell carcinoma (RCC) is the development of models that faithfully recapitulate early- and late-stage metastatic disease progression. (jove.com)

mouse


  • Hormone and/or drug pellets are easily manufactured with a pellet press, and surgically implanted into the subcutaneous tissue of the male mouse host. (jove.com)
  • In vivo imaging of androgen-mediated luciferase activity revealed several strongly expressing tissues in the male mouse as expected and also in certain female tissues. (jove.com)

patients


  • This protocol describes the key steps to develop RCC disease progression stages similar to patients. (jove.com)

models


  • Altered patterns of dendritic growth and plasticity are associated with impaired neurobehavioral function in experimental models 7 , and are thought to contribute to clinical symptoms observed in both neurodevelopmental disorders 8-10 and neurodegenerative diseases 11-13 . (jove.com)