*  Macromolecular Substances - Medical Dictionary

define Macromolecular Substances. Explain Macromolecular Substances. What is Macromolecular Substances? Macromolecular ... Macromolecular Substances. Medical Dictionary -> Macromolecular Substances. Search: Macromolecular Substances. Compounds and ... In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ...
medicaldictionaryweb.com/Macromolecular Substances-definition/

*  New Descriptors by Tree Subcategory - 2015

D5 (Macromolecular Substances). Frankincense. Hypromellose Derivatives. Protein Aggregates. D6 (Hormones, Hormone Substitutes, ... Metabolic Side Effects of Drugs and Substances. Ornithine Decarboxylase Inhibitors. Steroid Synthesis Inhibitors. Viral Fusion ...
https://nlm.nih.gov/mesh/newbysub.html

*  Biodegradable polymer networks based on oligolactide macromers: synthesis, properties and biomedical applications.

No./Substance: 0/Biocompatible Materials; 0/Bone Substitutes; 0/Macromolecular Substances; 0/Polyesters; 0/Polymers; 26969-66-4 ... Macromolecular Substances. Materials Testing / methods. Osteoblasts / metabolism*. Polyesters / chemistry*, pharmacokinetics*. ...
biomedsearch.com/nih/Biodegradable-polymer-networks-based-oligolactide/12202198.html

*  Polymer Synthesis: Theory and Practice (ebook) by Dietrich Braun | 9783642289804

Modification of Macromolecular Substances.- Functional Polymers. ... and head of the IPF Institute Macromolecular Chemistry. ... Matthias Rehahn holds a professorship at the Ernst-Berl-Institute for Technical and Macromolecular Chemistry at the Technical ... h. c. Helmut Ritter is head of the Institute of Organic Chemistry and Macromolecular Chemistry at the University Düsseldorf. ...
https://ebooks.com/972130/polymer-synthesis-theory-and-practice/braun-dietrich-cherdron-harald-rehahn-matthias/

*  Definitions of saccharide - OneLook Dictionary Search

... includes simple sugars with small molecules as well as macromolecular substances; are classified according to the number of ...
https://onelook.com/?w=saccharide&loc=wotd

*  Patent US4223011 - Therapeutic compositions containing polymers having polyunsaturated acid ... - Google Patents

... bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic or ... reaction of these macromolecular substances with alkylene-diamines, hydroxyalkilamines or alkylene dihydroxycompounds in order ... reaction of these macromolecular substances with alkylene-diamines, hydroxyalkilamines or alkylene dihydroxycompounds in order ... reactions of these new macromolecular substances with the polyunsaturated acids; ...
google.com.au/patents/US4223011

*  APS Physics | DPOLY | Division of Polymer Physics

The Division of Polymer Physics focuses on the physics of natural and synthetic macromolecular substances. ... The Division of Polymer Physics focuses on the physics of natural and synthetic macromolecular substances.. Benefits of ...
aps.org/units/dpoly/

*  carbohydrate :: Lexipedia - Where words have meaning

... includes simple sugars with small molecules as well as macromolecular substances; are classified according to the number of ...
lexipedia.com/english/carbohydrate

*  Polyether antibiotics monensin, narasin, & salinomycin on Environmental XPRT

RubberRubber is a collective term for macromolecular substances of natural rubber (NR) or synthetic rubber (SR) origin. Natural ...
https://environmental-expert.com/articles/polyether-antibiotics-monensin-narasin-salinomycin-174192

*  Gas Chromatography (Monitoring and Testing) Articles on Environmental XPRT

Rubber Rubber is a collective term for macromolecular substances of natural rubber (NR) or synthetic rubber (SR) origin. ...
https://environmental-expert.com/monitoring-testing/gas-chromatography/articles

*  Chromatograph Articles on Environmental XPRT

Rubber Rubber is a collective term for macromolecular substances of natural rubber (NR) or synthetic rubber (SR) origin. ... Most organic substances, and certainly the majority of pharmaceuticals, are polar, nonvolatile or thermally labile molecules ...
https://environmental-expert.com/articles/keyword-chromatograph-57058

*  IB2003003446 METHOD OF UNIFORMLY DISTRIBUTING A SUBSTANCE IN A SUBSTRATE

METHOD OF UNIFORMLY DISTRIBUTING A SUBSTANCE IN A SUBSTRATE ... Processes of treating or compounding macromolecular substances ... EN) METHOD OF UNIFORMLY DISTRIBUTING A SUBSTANCE IN A SUBSTRATE. (FR) PROCEDE DE REPARTITION UNIFORME D'UNE SUBSTANCE SUR UN ... EN)The invention relates to a new method for improved distribution of a substance or mix-ture of substances in a carrier or ... 1. (WO2004009682) METHOD OF UNIFORMLY DISTRIBUTING A SUBSTANCE IN A SUBSTRATE PCT Biblio. Data. Description. Claims. National ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2004009682

*  Nitric oxide inhalation - Mallinckrodt - AdisInsight

Macromolecular substances; Nitrogen oxides; Non-opioid analgesics; Small molecules; Vasodilators * Mechanism of Action ...
adisinsight.springer.com/drugs/800009315

*  JP2006313925 SOLID ELECTROLYTE MEMBRANE, METHOD AND APPARATUS FOR PRODUCING THE SAME, MEMBRANE ELECTRODE ASSEMBLY AND FUEL CELL

Manufacture of articles or shaped materials containing macromolecular substances. 20. Manufacture of shaped structures of ion- ... SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, ... ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON ... ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2007007824

*  US2001031962 INK JET INKS

Other features in dyeing or printing textiles, or dyeing leather, furs, or solid macromolecular substances in any form ... DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS, OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2002031067

*  GB2012050267 PIPE

SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, ... ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON ... SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; AFTER- TREATMENT OF THE SHAPED PRODUCTS, ... WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL ...
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012107753

*  Model of the molecular organization of juxtaparanodal r | Open-i

... the possibility that additional components are part of this macromolecular complex cannot be excluded, as TAG-1 has been shown ... the possibility that additional components are part of this macromolecular complex cannot be excluded, as TAG-1 has been shown ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172849_200305078f8&req=4

*  Neogenin enhances myogenic bHLH factor- and NFAT-depe | Open-i

Macromolecular Substances. *Membrane Glycoproteins/metabolism/physiology. *Myoblasts/metabolism. *NFATC Transcription Factors. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172498_200405039f6&req=4

*  EUR-Lex - 32014D0763 - EN - EUR-Lex

synthetic polymers' means macromolecular substances, other than cellulose pulp, intentionally obtained either by a ... If these are not available or the substance is self-classified then information shall be provided relevant to the substances ... The hazard statements and the risk phrases in table 4 generally refer to substances. However, if information on substances ... safety data sheets shall be provided for substances and mixtures used in the assembly of the final product or substances and ...
eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2014.320.01.0046.01.ENG

*  Patent US4680201 - Coating for electrophoresis tube - Google Patents

This polymeric layer inhibits electroendosmosis and adsorption of the substances to be separated onto the interior of the tube ... Zone deformation is a particular problem with macromolecular substances, such as proteins, which possess multiple binding sites ... Method for separating substances. US20060249558 *. Apr 10, 2006. Nov 9, 2006. Roach David J. Automated micro-volume assay ... This polymeric layer inhibits electroendosmosis and adsorption of the substances to be separated onto the interior of the tube ...
google.com/patents/US4680201?dq="virtual interaction configuration"

*  Patent US4680268 - Implantable gas-containing biosensor and method for measuring an analyte ... - Google Patents

The enclosed chamber is uniquely designed to be impermeable to substances, like liquid and cells, that possibly can interfere ... 4,040,908, I described a membrane polarographic anode suitable for measuring macromolecular substances, such as cholesterol, ... utilizing enzymatic reactions as a means to measure such macromolecular substances.. Additional techniques have been developed ... 3,539,455, small molecular substances, such as glucose, were measured with a membrane polarographic electrode system. By use of ...
google.com.au/patents/US4680268

*  Patent US4845132 - Hydrophilic porous membrane, method for production thereof, and plasma ... - Google Patents

The separation of substances as by filtration or dialysis using macromolecular porous membranes has found utility in numerous ... Among the hydrophilic monomers cited above, those which possess affinity for the hydrophobic macromolecular substance for the ... It has been held that the depth from the outer surface of a macromolecular material in which the treatment with plasma produces ... porous membrane used as a substrate herein is a porous membrane of the type formed of a hydrophobic macromolecular substance ...
google.com/patents/US4845132?dq=6175559

*  Patent WO1996002232A1 - Composition and method for enhancing transdermal electrotransport agent delivery - Google Patents

These macromolecular substances typically have a molecular weight of at least about 300 Daltons, and more typically, a ... The skin functions as the primary barrier to the transdermal penetration of external substances into the body and represents ... and are intended to have their broadest interpretation as any therapeutically active substance which is delivered to a living ...
google.com.au/patents/WO1996002232A1

*  Patent US4361647 - Sandwich immunoassay and compositions for use therein - Google Patents

... and complex macromolecular substances such as proteins that cause the formation of antibodies that are contained in the F(ab')2 ... Method for the determination of a substance capable of immunological binding. WO1984004169A1 *. Nov 28, 1983. Oct 25, 1984. ... Process for the determination of an immunologically-bindable substance involving a Fab fragment. ...
google.com/patents/US4361647?dq=oakley 5,387,949&ei=4yI4T8nkLYa80QG0xqnWAg

*  Patent US4256834 - Fluorescent scavenger particle immunoassay - Google Patents

... either with each other or with different particles or macromolecular substances, which may or may not be light absorbing. ... The method is predicated upon the ability to partition a chromogenic substance between a phase where the chromogenic substance ... Specific binding assay with an enzyme modulator as a labeling substance. US4160645 *. Jul 14, 1977. Jul 10, 1979. Syva Company ... Methods for determining peroxidatively active substances. US5346670 *. Jun 8, 1992. Sep 13, 1994. British Technology Group U.S. ...
google.com/patents/US4256834?dq=7,633,076

(1/19184) Molecular chaperones: small heat shock proteins in the limelight.

Small heat shock proteins have been the Cinderellas of the molecular chaperone world, but now the crystal structure of a small heat shock protein has been solved and mutation of two human homologues implicated in genetic disease. Intermediate filaments appear to be one of the key targets of their chaperone activity.  (+info)

(2/19184) Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts.

BACKGROUND: Coiled bodies are nuclear organelles that are highly enriched in small nuclear ribonucleoproteins (snRNPs) and certain basal transcription factors. Surprisingly, coiled bodies not only contain mature U snRNPs but also associate with specific chromosomal loci, including gene clusters that encode U snRNAs and histone messenger RNAs. The mechanism(s) by which coiled bodies associate with these genes is completely unknown. RESULTS: Using stable cell lines, we show that artificial tandem arrays of human U1 and U2 snRNA genes colocalize with coiled bodies and that the frequency of the colocalization depends directly on the transcriptional activity of the array. Association of the genes with coiled bodies was abolished when the artificial U2 arrays contained promoter mutations that prevent transcription or when RNA polymerase II transcription was globally inhibited by alpha-amanitin. Remarkably, the association was also abolished when the U2 snRNA coding regions were replaced by heterologous sequences. CONCLUSIONS: The requirement for the U2 snRNA coding region indicates that association of snRNA genes with coiled bodies is mediated by the nascent U2 RNA itself, not by DNA or DNA-bound proteins. Our data provide the first evidence that association of genes with a nuclear organelle can be directed by an RNA and suggest an autogenous feedback regulation model.  (+info)

(3/19184) Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome.

The vacuolar protein sorting (VPS) pathway of Saccharomyces cerevisiae mediates transport of vacuolar protein precursors from the late Golgi to the lysosome-like vacuole. Sorting of some vacuolar proteins occurs via a prevacuolar endosomal compartment and mutations in a subset of VPS genes (the class D VPS genes) interfere with the Golgi-to-endosome transport step. Several of the encoded proteins, including Pep12p/Vps6p (an endosomal target (t) SNARE) and Vps45p (a Sec1p homologue), bind each other directly [1]. Another of these proteins, Vac1p/Pep7p/Vps19p, associates with Pep12p and binds phosphatidylinositol 3-phosphate (PI(3)P), the product of the Vps34 phosphatidylinositol 3-kinase (PI 3-kinase) [1] [2]. Here, we demonstrate that Vac1p genetically and physically interacts with the activated, GTP-bound form of Vps21p, a Rab GTPase that functions in Golgi-to-endosome transport, and with Vps45p. These results implicate Vac1p as an effector of Vps21p and as a novel Sec1p-family-binding protein. We suggest that Vac1p functions as a multivalent adaptor protein that ensures the high fidelity of vesicle docking and fusion by integrating both phosphoinositide (Vps34p) and GTPase (Vps21p) signals, which are essential for Pep12p- and Vps45p-dependent targeting of Golgi-derived vesicles to the prevacuolar endosome.  (+info)

(4/19184) Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances.

Transcription factors that are bound specifically to DNA often interact with each other over thousands of base pairs [1] [2]. Large DNA loops resulting from such interactions have been observed in Escherichia coli with the transcription factors deoR [3] and NtrC [4], but such interactions are not, as yet, well understood. We propose that unique protein complexes, that are not present in solution, may form specifically on DNA. Their uniqueness would make it possible for them to interact tightly and specifically with each other. We used the repressor and operators of coliphage lambda to construct a model system in which to test our proposition. lambda repressor is a dimer at physiological concentrations, but forms tetramers and octamers at a hundredfold higher concentration. We predict that two lambda repressor dimers form a tetramer in vitro when bound to two lambda operators spaced 24 bp apart and that two such tetramers interact to form an octamer. We examined, in vitro, relaxed circular plasmid DNA in which such operator pairs were separated by 2,850 bp and 2,470 bp. Of these molecules, 29% formed loops as seen by electron microscopy (EM). The loop increased the tightness of binding of lambda repressor to lambda operator. Consequently, repression of the lambda PR promoter in vivo was increased fourfold by the presence of a second pair of lambda operators, separated by a distance of 3,600 bp.  (+info)

(5/19184) Stable remodeling of tailless nucleosomes by the human SWI-SNF complex.

The histone N-terminal tails have been shown previously to be important for chromatin assembly, remodeling, and stability. We have tested the ability of human SWI-SNF (hSWI-SNF) to remodel nucleosomes whose tails have been cleaved through a limited trypsin digestion. We show that hSWI-SNF is able to remodel tailless mononucleosomes and nucleosomal arrays, although hSWI-SNF remodeling of tailless nucleosomes is less effective than remodeling of nucleosomes with tails. Analogous to previous observations with tailed nucleosomal templates, we show both (i) that hSWI-SNF-remodeled trypsinized mononucleosomes and arrays are stable for 30 min in the remodeled conformation after removal of ATP and (ii) that the remodeled tailless mononucleosome can be isolated on a nondenaturing acrylamide gel as a novel species. Thus, nucleosome remodeling by hSWI-SNF can occur via interactions with a tailless nucleosome core.  (+info)

(6/19184) Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.  (+info)

(7/19184) Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.

The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.  (+info)

(8/19184) Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.  (+info)



Proteins


  • Zone deformation is a particular problem with macromolecular substances, such as proteins, which possess multiple binding sites capable of interacting strongly with the inner wall of the tube. (google.com)

Polymers


  • More precisely, the present invention concerns high polymers containing radicals of the eioosatrienoic, eicosatetraenoic, or eicosapentenoic acids bound to the macromolecular matrix by ester or amide bonds, which radicals ar gradually hydrolyzed in a predetermined way in biological systems and contemporaneously cyclized to give free prostaglandins. (google.com.au)

chemistry


  • Since 1999 Prof. Dr. Matthias Rehahn holds a professorship at the Ernst-Berl-Institute for Technical and Macromolecular Chemistry at the Technical University Darmstadt, and he is the leader of the German Institute for Synthetic Materials in Darmstadt. (ebooks.com)
  • Helmut Ritter is head of the Institute of Organic Chemistry and Macromolecular Chemistry at the University Düsseldorf. (ebooks.com)
  • Prof. Dr. Brigitte Voit is Managing Director/Chief Scientific Officer (CSO) of the "Leibniz-Institut für Polymerforschung Dresden e.V." (IPF) and head of the IPF Institute Macromolecular Chemistry. (ebooks.com)

synthetic


  • The Division of Polymer Physics focuses on the physics of natural and synthetic macromolecular substances. (aps.org)
  • RubberRubber is a collective term for macromolecular substances of natural rubber (NR) or synthetic rubber (SR) origin. (environmental-expert.com)

Materials


  • The criteria should, in particular, promote sustainable sourcing of materials, limited use of hazardous substances, high-quality and high-performance products which are fit-for-use and are designed to minimise waste production. (europa.eu)