Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Lymph: The interstitial fluid that is in the LYMPHATIC SYSTEM.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Lymphatic System: A system of organs and tissues that process and transport immune cells and LYMPH.Axilla: Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.Mesentery: A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.Tuberculosis, Lymph Node: Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Lymphatic Diseases: Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.Mediastinum: A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Lymphatic Vessels: Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.Breast Neoplasms: Tumors or cancer of the human BREAST.Spleen: An encapsulated lymphatic organ through which venous blood filters.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Neck: The part of a human or animal body connecting the HEAD to the rest of the body.Lymphoid Tissue: Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Stomach Neoplasms: Tumors or cancer of the STOMACH.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Lymphography: Radiographic study of the lymphatic system following injection of dye or contrast medium.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Mice, Inbred BALB CAdenocarcinoma: A malignant epithelial tumor with a glandular organization.Mice, Inbred C57BLCarcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Lymphadenitis: Inflammation of the lymph nodes.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Neck Dissection: Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.Lymphangiogenesis: The formation of LYMPHATIC VESSELS.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Skin Neoplasms: Tumors or cancer of the SKIN.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Neoplasm Micrometastasis: Newly arising secondary tumors so small they are difficult to detect by physical examination or routine imaging techniques.Technetium Compounds: Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.Groin: The external junctural region between the lower part of the abdomen and the thigh.Peyer's Patches: Lymphoid tissue on the mucosa of the small intestine.Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Vascular Endothelial Growth Factor C: A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.Giant Lymph Node Hyperplasia: Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Technetium Tc 99m Sulfur Colloid: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.Inguinal Canal: The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.Receptors, CCR7: CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Retroperitoneal Space: An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.Chemokine CCL21: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.Lymphatic Irradiation: External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Histiocytes: Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Langerhans Cells: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.False Negative Reactions: Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Thymus Gland: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.Oxazolone: Immunologic adjuvant and sensitizing agent.L-Selectin: Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Mastectomy: Surgical procedure to remove one or both breasts.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Coloring Agents: Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.Rectal Neoplasms: Tumors or cancer of the RECTUM.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.Chylomicrons: A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.T-Lymphocyte Subsets: A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Mediastinoscopy: Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)Cystectomy: Used for excision of the urinary bladder.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Vascular Endothelial Growth Factor D: A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR C in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Esophagectomy: Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Endosonography: Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Mouth Neoplasms: Tumors or cancer of the MOUTH.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Palatine Tonsil: A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.Lymphotoxin-beta: A membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Chemokine CCL19: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Antibody-Producing Cells: Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.T-Lymphocytes, Regulatory: CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Receptors, Lymphocyte Homing: Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialized blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes.Vulvar Neoplasms: Tumors or cancer of the VULVA.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Multimodal Imaging: The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.Mice, Inbred CBACell Line, Tumor: A cell line derived from cultured tumor cells.Antigens, CD11c: An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Keratin-19: A type I keratin found associated with KERATIN-7 in ductal epithelia and gastrointestinal epithelia.Bacterial Translocation: The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.Receptors, Chemokine: Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Penile Neoplasms: Cancers or tumors of the PENIS or of its component tissues.Antigen Presentation: The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.Intraoperative Period: The period during a surgical operation.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Lymphocyte Subsets: A classification of lymphocytes based on structurally or functionally different populations of cells.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Mice, Inbred C3HGranuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Picryl Chloride: A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Cytodiagnosis: Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)Interleukin-4: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

*  Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid? | IOVS | ARVO Journals
... "lymph") pressure within the choroid is managed are relevant for ocular homeostasis. As such, a major aim of our study was to ... as well as a pathway from the eye to the sentinel lymph nodes, similar to that described for the anterior uveal lymphatic ...
*  The Lymphatic System and Ways to Improve It | Cancer Crackdown
Lymph vessels are the main component in the lymphatic system and these vessels transfer the lymph fluid from extremities to the ... tumor can become trapped inside the lymph nodes or lymph vessels or they can even start spreading in opposition to lymph flow ... Lymph Cleanse Recipe:. Dry skin brush for around five minutes during hot bath.. Add one cup of baking soda, one cup of Epsom ... Lymph nodes are another important part of this system. These nodes are essential part of the immune system and they locate, ...
*  High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer | BMC Cancer...
Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis. Breast J. ... the frequency of lymphovascular invasion per tumor lesion has no effects on prognosis in lymph node negative and lymph node ... Zhang Z-Q, Han Y-Z, Nian Q, Chen G, Cui S-Q, Wang X-Y. Tumor invasiveness, not Lymphangiogenesis, is correlated with lymph node ... Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer. Mod ...
*  Prescapular Lymph Node
Definition of Prescapular Lymph Node. Prescapular Lymph Node FAQ. Learn more about Prescapular Lymph Node. Prescapular Lymph ... A lymph node located in front of the shoulder.. Prescapular Lymph Node Synonyms. Prescapular Lymph Node. Terms in Prescapular ... Prescapular Lymph Node. Cancer Terms -> Experimental Organism Anatomical Concepts -> Prescapular Lymph Node. Prescapular Lymph ... Lymph Node category. Copyright © Cancer Terms 2014 All rights reserved. , Terms of Use , Low Carb Foods. No reproduction or ...
*  P172 Training nurses in sampling and acquisition of specimen during EBUS guided transbronchial needle aspiration | Thorax
200 lymph nodes (2R, 4R, 4L, 7, 10R, 10L, 11R) and 13 lung lesions were biopsied. Results were as follows: Adequate samples ...
*  Characterization and Management of Paradoxical Upgrading Reactions in HIV-Uninfected Patients with Lymph Node Tuberculosis :...
In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected ... In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected ...
Since lymph is 95% water, dehydration is one of the most common causes of lymph congestion. Without proper amounts of water, ... Drink these herbal teas and will effectively detoxify the lymph:. Red root is a herb that is useful in reducing swollen lymph ... They can irritate intestinal villi, the main reason for lymph congestion. The fact that the majority of the lymph in the body ... Tag Archives: DANGER SIGNS THAT YOUR LYMPHATIC SYSTEM IS SLUGGISH AND HOW TO DO A LYMPH DETOX. DANGER SIGNS THAT YOUR LYMPHATIC ...
*  Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis | IOVS | ARVO Journals
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol. 1999; 144: 789-801 ... and function to direct lymph flow in inflamed corneas.16,17 However, the direct role of Itga-9 in corneal lymphatic valve ... 1 and their luminal valves function to direct lymph (containing immune cells) flow inside the vessels, it is speculated that by ...
*  16 Ways to Lose Weight Fast Lymphatic system functions
... lymph), vessels that transport the lymph, and organs that contain lymphoid tissue.Lymphatic system absorbs fluid from the ... Video 14 Lymph System. The lymphatic system also serves as a connection between tissues and the bloodstream, performing several ... The lymphatic system is the system in the body that transport lymph, which is a tissue-cleaning fluid, from the tissues into ... and lymph flow. In:.Print Exercise 35A: The Lymphatic System and Immune System flashcards and study them anytime, anywhere. ...
*  P289 Isolated Mediastinal and/or Hilar Lymphadenopathy: what can EBUS-TBNA add? | Thorax
IMHL was defined as the presence of enlarged mediastinal/hilar lymph nodes on computer tomography (CT) without suggestion of ...
*  swollen lymph nodes and more - I cannot get a diagnosis. - Condition | Our Health
These lymph nodes often swell during sore throats and ear infections. Swollen lymph nodes down the sides or back of the neck ... Infections are the most common cause of swollen lymph nodes. The location of the swollen lymph node can tell you where the ... Allergies and bug bites can also cause lymph nodes to swell.Most people connect the term "swollen glands" with the lymph nodes ... may cause lymph nodes in the groin to swell. A swollen lymph node in the armpit might be from an infected cut on the arm or ...
*  Pancreatic pseudo-tumor caused by bilio-pancreatic tuberculous lymphadenitis. 2 cases]. - Semantic Scholar
... or posterior lymph nodes responsible for chronic epigastric pain. Endoscopic retrograde cholangiopancreatography is essential ... either anterior lymph nodes responsible for obstructive jaundice, ... either anterior lymph nodes responsible for obstructive jaundice, or posterior lymph nodes responsible for chronic epigastric ...
*  lymphatic system - Kids | Britannica Kids |...
Major parts of the lymphatic system include the lymphatic vessels, the lymph nodes, and cells called lymphocytes. The spleen, ... Major parts of the lymphatic system include the lymphatic vessels, the lymph nodes, and cells called lymphocytes. The spleen, ...
*  The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response. | JEM
The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response.. J B Hay, B B Hobbs ... A popliteal node of the sheep received 0.014% of the cardiac output and a comparable node in the rabbit 0.011%. A sheep lymph ... It was calculated that an equivalent to 60% of the entire mobilizable pool of lymphocytes could pass through an average lymph ... During the immune response to either allogeneic lymphocytes or tuberculin, the blood flow to sheep lymph nodes, even without ...
*  Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer - Full Text View -...
Lymph node mapping may help in planning surgery to remove breast cancer and affected lymph nodes. It is not yet known whether ... Procedure: axillary lymph node dissection Undergo reverse mapping-guided axillary lymph node dissection ... Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer. This study has been terminated ... Procedure: axillary lymph node dissection Drug: isosulfan blue based lymphatic mapping Procedure: quality-of-life assessment ...
*  Lymph node biopsy - Wikipedia
Lymph node biopsy is a test in which a lymph node or a piece of a lymph node is removed for examination under a microscope (see ... The lymph nodes also try to trap cancer cells. The test is used to help determine the cause of lymph node enlargement (swollen ... biopsy). The lymphatic system is made up of several lymph nodes connected by lymph vessels. The nodes produce white blood cells ... However, Sentinel lymph node biopsy for evaluating early, thin melanoma has not been shown to improve survival, and for this ...
*  Lymph node stromal cell - Wikipedia
The lymph carries chemokines (molecular chemical messengers) and antigens to the lymph node. At the lymph node, the lymph ... Afferent lymphatic vessels bring lymph fluid from the peripheral tissues to the lymph nodes. The lymph tissue in the lymph ... This is the place where blood vessels enter and leave the lymph node and lymphatic vessels leave the lymph node. Lymph vessels ... Lymph node stromal cells are essential to the structure and function of the lymph node. There are a number of different types ...
*  Lymph trunk - Wikipedia
... right lymph duct and the thoracic duct). When an efferent lymph vessel leaves a lymph node, it may carry lymph to another lymph ... Jugular lymph trunks Subclavian lymph trunks Bronchomediastinal lymph trunks Lumbar lymph trunks Intestinal lymph trunk- ... Lymph trunk is a collection of lymph vessels that carries lymph, and is formed by confluence of many efferent lymph vessels. It ... The lymph trunks drain into the lymph ducts, which in turn return lymph to the blood by emptying into the respective subclavian ...
*  Lymph capillary - Wikipedia
Each lymphatic capillary carries lymph into a lymphatic vessel, which in turn connects to a lymph node. Lymph is ultimately ... Lymph capillaries or lymphatic capillaries are tiny, thin-walled microvessels located in the spaces between cells (except in ... Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma ... Diagram showing the formation of lymph from interstitial fluid (labeled here as "Tissue fluid"). Note: how the tissue fluid is ...
*  Lymph Nodes
... sometimes called lymph glands) filter lymph fluid as it flows through them, trapping bacteria, viruses, and other foreign . ... The lymphatic system is also an important part of the immune system, the body's defense system against disease.The lymph nodes ... which carries lymph fluid, nutrients, and waste material between the body tissues and the bloodstream. ... Lymph nodes are part of the lymphatic system, ... Lymph Nodes. Lymph nodes are part of the lymph system, which ...
*  Pararectal lymph nodes - Wikipedia
The pararectal lymph nodes are in contact with the muscular coat of the rectum. They drain the descending iliac and sigmoid ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Pararectal_lymph_nodes&oldid=657024966" ...
*  Lymph Nodes
... This website displays images of various lymph nodes including those in the head, arm, and lungs etc. The images ... allow the viewer to observe where the lymph nodes are located in the body. ...
*  Jugulodigastric lymph node - Wikipedia
The jugulodigastric lymph node is a large node found in the proximity of where the posterior belly of the digastric muscle ... Enlarged jugulodigastric lymph nodes are also commonly found in tonsillitis. Worzala, Katherine; Dale Berg (2006). Atlas of ...
*  Lymph | physiology | Britannica.com
Prominent among the constituents of lymph are lymphocytes and macrophages, the primary cells of the immune ... Lymph, pale fluid that bathes the tissues of an organism, maintaining fluid balance, and removes bacteria from tissues; it ... Lymph flows more slowly than blood. The cell walls of lymph vessels are more permeable than those of the capillary walls of ... Bacteria and other particles that find their way into body tissues are taken up by the lymph and carried into the lymph nodes, ...
*  lymph vessel
This fluid is a pale, watery substance known as lymph. ... A lymph vessel is a vessel that, unlike a blood vessel, carries ... called lymph trunks, which drain large regions. Lymph trunks merge until the lymph enters two main channels called lymph ducts ... The smallest lymph vessels are the lymph capillaries, which begin in the tissue spaces as blind-ended sacs. Lymph capillaries ... Before lymph is returned to the blood, it passes through lymph nodes where it is exposed to the cells of the immune system. ...

Inferior mesenteric lymph nodes: The inferior mesenteric lymph nodes consist of:Lymphovascular invasionLymph: Lymph is the fluid that circulates throughout the lymphatic system. The lymph is formed when the interstitial fluid (the fluid which lies in the interstices of all body tissues)Fluid Physiology: 2.Tuberculous lymphadenitisABCD rating: ABCD rating, also called the Jewett staging system or the Whitmore-Jewett staging system, is a staging system for prostate cancer that uses the letters A, B, C, and D.Dermatopathic lymphadenopathyLymphangionBreast cancer classification: Breast cancer classification divides breast cancer into categories according to different schemes, each based on different criteria and serving a different purpose. The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes.Periarteriolar lymphoid sheaths: Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen. They are populated largely by T cells and surround central arteries within the spleen; the PALS T-cells are presented with blood borne antigens via myeloid dendritic cells.Intraepithelial lymphocyte: Intraepithelial lymphocytes (IEL) are lymphocytes found in the epithelial layer of mammalian mucosal linings, such as the gastrointestinal (GI) tract and reproductive tract. However, unlike other T cells, IELs do not need priming.Acute myeloid dendritic cell leukemia: Acute myeloid dendritic cell leukemia is an exceedingly rare form of leukemia. This form of leukemia represents only about 0.PMHC cellular microarray: PMHC cellular microarrays are a type of cellular microarray that has been spotted with pMHC complexes peptide-MHC class I or peptide-MHC class II.Adenocarcinoma of the lung: Adenocarcinoma of the lung (pulmonary adenocarcinoma) is a common histological form of lung cancer that contains certain distinct malignant tissue architectural, cytological, or molecular features, including gland and/or duct formation and/or production of significant amounts of mucus.Squamous-cell carcinomaMarseillevirus: Marseillevirus is a genus of viruses, in the family Marseilleviridae. There are currently only two species in this genus, including the type species Marseillevirus marseillevirus.Haptotaxis: Haptotaxis (from Greek ἅπτω (hapto, "touch, fasten") and τάξις (taxis, "arrangement, order")) is the directional motility or outgrowth of cells, e.g.James A. Schlipmann Melanoma Cancer Foundation: The James A. Schlipmann Melanoma Cancer Foundation is a US-based non-profit organization with a mission to fund clinical trials and research studies, and to advance education, awareness, screenings and treatment to eventually eradicate melanoma.Cancer biomarkers: A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.Neck dissectionLymphangiogenesis: Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development).Anaplastic carcinoma: Anaplastic carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed cells of epithelial origin, or showing some epithelial characteristics, but that reveal no cytological or architectural features of associated with more differentiated tumors, such as the glandular formation or special cellular junctions that typical of adenocarcinoma and squamous cell carcinoma, respectively.Assay sensitivity: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.Corriedale: Corriedale sheep are a dual purpose breed, meaning they are used both in the production of wool and meat. The Corriedale is the oldest of all the crossbred breeds, a Merino-Lincoln cross developed almost simultaneously in Australia and New ZealandStock Types, The Land, North Richmond, c.GastrectomyLumpectomyCancer survival rates: Cancer survival rates vary by the type of cancer, stage at diagnosis, treatment given and many other factors, including country. In general survival rates are improving, although more so for some cancers than others.BectumomabGroin: In human anatomy, the groin (the adjective is inguinal, as in inguinal canal) is the junctional area (also known as the inguinal region) between the abdomen and the thighon either side of the pubic bone. This is also known as the medial compartment of the thigh that consists of the adductor muscles of the hip or the groin muscles.Peyer's patch: Peyer's patches (or aggregated lymphoid nodules, or occasionally PP for brevity) are organized lymphoid nodules, named after the 17th-century Swiss anatomist Johann Conrad Peyer. They are aggregations of lymphoid tissue that are usually found in the lowest portion of the small intestine, the ileum, in humans; as such, they differentiate the ileum from the duodenum and jejunum.FuchsineTemporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingCastleman's diseaseSuperficial external pudendal artery: The superficial external pudendal artery (superficial external pudic artery) arises from the medial side of the femoral artery, close to the superficial epigastric artery and superficial iliac circumflex artery.Clinical endpoint: In a clinical research trial, a clinical endpoint generally refers to occurrence of a disease, symptom, sign or laboratory abnormality that constitutes one of the target outcomes of the trial, but may also refer to any such disease or sign that strongly motivates the withdrawal of that individual or entity from the trial, then often termed humane (clinical) endpoint.History and naming of human leukocyte antigens: Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing and performing massive statistical analyses on interactions between blood types.Retroperitoneal hemorrhageBreast biopsyAvid Radiopharmaceuticals: Avid Radiopharmaceuticals is an American company, founded by Dr. Daniel Skovronsky, and based at the University City Science Center research campus in Philadelphia, Pennsylvania.Immunoperoxidase: Immunoperoxidase is a type of immunostain used in molecular biology, medical research, and clinical diagnostics. In particular, immunoperoxidase reactions refer to a sub-class of immunohistochemical or immunocytochemical procedures in which the antibodies are visualized via a peroxidase-catalyzed reaction.Flow cytometry: In biotechnology, flow cytometry is a laser-based, biophysical technology employed in cell counting, cell sorting, biomarker detection and protein engineering, by suspending cells in a stream of fluid and passing them by an electronic detection apparatus. It allows simultaneous multiparametric analysis of the physical and chemical characteristics of up to thousands of particles per second.HistiocyteLung receptor: Lung receptors sense irritation or inflammation in the bronchi and alveoli.Dermal equivalent: The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel.Thyroid cancerLangerin: CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.Immunophenotyping: Immunophenotyping is a technique used to study the protein expressed by cells. This technique is commonly used in basic science research and laboratory diagnostic purpose.Invasive lobular carcinomaHassall's corpuscles: Hassall's corpuscles (or thymic corpuscles (bodies)) are structures found in the medulla of the human thymus, formed from eosinophilic type VI epithelial reticular cells arranged concentrically. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells.C3H3NO2Head and Neck Cancer Alliance: The Head and Neck Cancer Alliance (HNCA) is a non-profit organization that works with health professionals and organizations, celebrities and survivors to enhance the overall effort in prevention, treatment, and detection of cancers of the head and neck region.MastectomyBrain positron emission tomography: Positron emission tomography (PET) measures emissions from radioactively labeled metabolically active chemicals that have been injected into the bloodstream. The emission data are computer-processed to produce multi-dimensional images of the distribution of the chemicals throughout the brain.PanitumumabOvalbumin: Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor.Chylomicron: Chylomicrons (from the Greek chylo, meaning juice or milky fluid, and micron, meaning small particle) are lipoprotein particles that consist of triglycerides (85–92%), phospholipids (6–12%), cholesterol (1–3%), and proteins (1–2%).M Mahmood Hussain: "Review Article: A proposed model for the assembly of chylomicrons"; Arterosclerosis; Vol.Brain biopsyAbscopal effect: The abscopal effect is a phenomenon in the treatment of metastatic cancer where localized treatment of a tumor causes not only a shrinking of the treated tumor but also a shrinking of tumors in different compartments from the treated tumor. Initially associated with single-tumor, localized radiation therapy, the term has also come to encompass other types of localized treatments such as electroporation and intra-tumoral injection of therapeutics.Mature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.Gross pathology: Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.

(1/833) Lymph and pulmonary response to isobaric reduction in plasma oncotic pressure in baboons.

Plasma colloid osmotic pressure was reduced by 76% (from 19.6 +/- 0.6 to 4.7 +/- 1.5 mm Hg) in five baboons while pulmonary capillary hydrostatic pressure was maintained at a normal level. This resulted in fluid retention, weight gain, peripheral edema and ascites, but no pulmonary edema. Thoracic duct lymph flow increased 6-fold and pulmonary lymph flow 7-fold. Thoracic duct lymph had a lower colloid osmotic pressure (2.0 +/- 0.7 mm Hg) than plasma (4.7 +/- 1.5 mm Hg), whereas the colloid osmotic pressure of pulmonary lymph (4.7 +/- 0.7 mm Hg) was the same as that of plasma. The lymph-plasma ratio for albumin fell in thoracic duct lymph but remained unchanged in pulmonary lymph. The difference between plasma colloid osmotic pressure and pulmonary artery wedge pressure decreased from 15.3 +/- 1.9 to -0.7 +/- 2.9 mm Hg. Despite this increase in filtration force, the lungs were protected from edema formation by a decrease of 11 mm Hg in pulmonary interstitial colloid osmotic pressure and a 7-fold increase in lymph flow.  (+info)

(2/833) An isolated perfused rat lung preparation.

An isolated perfused rat lung preparation (IPL) is described and its physiologic status is evaluated. The evaluation includes light and electron microscopy after perfusion and estimations of substrate utilization. ATP content, lactate production, and incorporation of glucose carbons into lipids and CO2. It is concluded that the IPL is useful for short-term metabolic and physiologic experiments and offers some unique advantages in evaluating effects of reactive gases upon lung function.  (+info)

(3/833) Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep.

The effects of a monoclonal antibody against L-selectin [leukocyte adhesion molecule (LAM)1-3] on microvascular fluid flux were determined in conscious sheep subjected to a combined injury of 40% third-degree burn and smoke inhalation. This combined injury induced a rapid increase in systemic prefemoral lymph flow (sQlymph) from the burned area and a delayed-onset increase in lung lymph flow. The initial increase in sQlymph was associated with an elevation of the lymph-to-plasma oncotic pressure ratio; consequently, it leads to a predominant increase in the systemic soft tissue permeability index (sPI). In an untreated control group, the increased sPI was sustained beyond 24 h after injury. Pretreatment with LAM1-3 resulted in earlier recovery from the increased sPI, although the initial responses in sQlymph and sPI were identical to those in the nontreatment group. The delayed-onset lung permeability changes were significantly attenuated by pretreatment with LAM1-3. These findings indicate that both leukocyte-dependent and -independent mechanisms are involved in the pathogenesis that occurs after combined injury with burn and smoke inhalation.  (+info)

(4/833) Transport of colloidal particles in lymphatics and vasculature after subcutaneous injection.

This study was designed to determine the transport of subcutaneously injected viral-size colloid particles into the lymph and the vascular system in the hind leg of the dog. Transport of two colloid particles, with average size approximately 1 and 0.41 microm, respectively, and with and without leg rotation, was tested. Leg rotation serves to enhance the lymph flow rates. The right femoral vein, lymph vessel, and left femoral artery were cannulated while the animal was under anesthesia, and samples were collected at regular intervals after subcutaneous injection of the particles at the right knee level. The number of particles in the samples were counted under fluorescence microscopy by using a hemocytometer. With and without leg rotation, both particle sets were rapidly taken up into the venous blood and into the lymph fluid. The number of particles carried away from the injection site within the first 5 min was <5% of the injected pool. Particles were also seen in arterial blood samples; this suggests reflow and a prolonged residence time in the blood. These results show that particles the size of viruses are rapidly taken up into the lymphatics and blood vessels after subcutaneous deposition.  (+info)

(5/833) Human follicular dendritic cells remain uninfected and capture human immunodeficiency virus type 1 through CD54-CD11a interaction.

It has been reported that human immunodeficiency virus type 1 (HIV-1) bound to follicular dendritic cells (FDCs) remains highly infectious to CD4(+) T cells even when it forms immune complexes with neutralizing antibody (HIV-1/IC). To elucidate the role of FDCs in HIV-1 transmission to CD4(+) T cells in lymph nodes, we have isolated and purified FDCs from human tonsils and examined whether the HIV-1/IC trapped on their surface is infectious to CD4(+) T cells. To our surprise, not the HIV-1/IC but the antibody-free HIV-1 on FDCs could be transmitted to CD4(+) T cells. Furthermore, in contrast to previous studies showing that FDCs are productively infected with HIV-1, the present study clearly demonstrated that FDCs were not the target cells for HIV-1 infection. FDCs could capture the viral particles on their surface; however, the binding of HIV-1 to FDCs was strongly inhibited by the presence of anti-CD54 (ICAM-1) monoclonal antibody (MAb) and anti-CD11a (LFA-1) MAb, suggesting that the adhesion molecules play an important role in the interaction between HIV-1 and FDCs.  (+info)

(6/833) Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph.

Recent studies have shown that the central nervous system (CNS) communicates with the periphery by the drainage of cerebrospinal fluid and brain interstitial fluid into blood and lymph. We hypothesized that tumor necrosis factor (TNF)-alpha would not only influence the CNS by promoting sleep but also would be directly transmitted into the peripheral immune system. Five hundred nanograms of 125I-labeled TNF-alpha were injected into the lateral ventricles of the brain of six sheep and sampled in venous blood and cervical and prescapular lymph every 30 min for 6 h. 125I-TNF-alpha was measured in lymph nodes and control fat, skin, and muscle tissues 6 h postinjection. 125I-TNF-alpha was detected in the cervical lymphatics within the first 30 min and peaked within 2-3 h. 125I-TNF-alpha counts were elevated in the nodes of the head and neck region. Polysomnographic recordings of four animals showed that TNF-alpha induced a significant increase in slow-wave sleep at postinjection hours 4 and 5. CNS TNF-alpha and its direct drainage into the lymphatic system may influence both the sleeping/waking brain and peripheral immune functions.  (+info)

(7/833) The standard peritoneal permeability analysis in the rabbit: a longitudinal model for peritoneal dialysis.

OBJECTIVE: The development of an experimental peritoneal dialysis (PD) model in rabbits to investigate peritoneal transport characteristics during a longitudinal follow-up and to assess normal values of these peritoneal transport parameters. DESIGN: Peritoneal transport parameters were determined in conscious, unrestrained rabbits by standard peritoneal permeability analysis adjusted for rabbits (SPAR). In this test a 1-hour dwell with 3.86% glucose dialysate is used. Dextran 70 (1g/L) was added to the dialysate to allow calculation of fluid kinetics. Dialysate samples were taken before, 10, and 40 minutes after instillation and at the end of the dwell. Blood was drawn at the end of the dwell. EXPERIMENTAL ANIMALS: Eighteen female New Zealand White rabbits (2565 g) were included for catheter implantation. SPARs were performed in 15 animals; the other 3 were excluded due to complications. MAIN OUTCOME: The mass transfer area coefficients (MTACs) of the low molecular weight solutes urea (MTAC(urea)) and creatinine (MTACcr) were calculated. The clearances of albumin (CIalb) and IgG (CI(IgG)), glucose absorption, and fluid transport were computed. Coefficients of intraindividual variation (Vc) were calculated for these parameters. RESULTS: The main complications were catheter obstruction and/or dislocation. Five rabbits underwent uncomplicated PD during a 4-week period. Fifteen SPARs in 15 stable rabbits were performed and analyzed to obtain normal values. Means and standard deviations of the transport parameters were as follows: MTAC(urea) 2.24+/-0.57 mL/min, MTACcr 1.61+/-0.30 mU/min, CI(alb) 52.9+/-17.2 microL/min, CI(IgG) 44.5+/-22.9 UL/min. The transcapillary ultrafiltration rate was 0.66+/-0.13 mL/min and the lymphatic absorption rate 0.47+/-0.26 mL/min. The parameters of solute transport were upscaled to those in humans using two different methods. MTACs of low molecular weight solutes in rabbits and patients were of the same order of magnitude, but the clearance of albumin was approximately four times higher in rabbits than in patients, and that of IgG eight times. In all rabbits sieving of sodium was observed. The dialysate/plasma (D/P) of sodium decreased to a minimum at 40 min (p<0.003 vs the initial value), followed by a rise to 60 min. The minimal value was 0.884+/-0.002. The coefficients of variation calculated on 7 rabbits that underwent two or more SPARs were similar to those assessed from the patient data. This indicates stability of the model and reproducibility of the SPAR. CONCLUSION: The conscious rabbit model for PD can be used for repeated studies on peritoneal transport.  (+info)

(8/833) Contamination of lymph from the major prenodal cardiac lymphatic in dogs.

Cannulation of the canine major prenodal cardiac lymphatic (MPCL) is the most common approach for the investigation of myocardial lymphatic function. However, the assumption that the MPCL drains pure cardiac lymph has been questioned. We studied variations of MPCL anatomy and investigated whether noncardiac lymph is drained by this lymphatic. After dye was injected into the lungs and left ventricular myocardium in 21 dogs, dissection of the cardiac lymphatic system yielded 3 anatomic variations. In variations 1 and 2 (81% of dogs), a mixture of cardiac and pulmonary lymph was drained via the MPCL. In variation 3 (19% of dogs) no connection was found between MPCL and pulmonary lymphatics. In variations 1 and 2, alteration of tidal volume resulted in significant changes of lymph flow rate. The pulmonary contribution to MPCL lymph flow was estimated as 34% in variation 2. We conclude that MPCL lymph may contain not only cardiac lymph but also significant pulmonary contamination. This finding should be considered in the interpretation of lymph data from cannulation of the canine MPCL.  (+info)

  • node
  • 7 ] showed that lymphovascular invasion, but not lymphangiogenesis, was correlated with lymph node metastasis and poor prognosis in young breast cancer patients. (biomedcentral.com)
  • A lymph node located in front of the shoulder. (cancerterms.net)
  • In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected patients was common, occurring in 25 (23%) of 109 patients after treatment had been given for a median of 46 days (interquartile range, 21-139 days) and persisting for a median of 67.5 days (interquartile range, 34-111 days). (oup.com)
  • Lymph node biopsy is a test in which a lymph node or a piece of a lymph node is removed for examination under a microscope (see: biopsy). (wikipedia.org)
  • The test is used to help determine the cause of lymph node enlargement (swollen glands or lymphadenitis). (wikipedia.org)
  • It may also determine whether tumors in the lymph node are cancerous or noncancerous. (wikipedia.org)
  • The pathologist may also perform additional tests on the lymph node tissue to assist in making a diagnosis. (wikipedia.org)
  • Some of the conditions where abnormal values are obtained are: Hodgkin's lymphoma Non-Hodgkin's lymphoma Sarcoidosis tuberculous cervical lymphadenitis (scrofula) Lymph node biopsies may be performed to evaluate the spread of cancer. (wikipedia.org)
  • However, Sentinel lymph node biopsy for evaluating early, thin melanoma has not been shown to improve survival, and for this reason, should not be performed. (wikipedia.org)
  • A small incision is made, and the lymph node or part of the node is removed. (wikipedia.org)
  • Additionally, there is a moderate risk of nerve injury, localized paralysis, or numbness when the biopsy is performed on a lymph node close to nerves. (wikipedia.org)
  • Lymph node stromal cells are essential to the structure and function of the lymph node. (wikipedia.org)
  • The interior of the lymph node has two regions: the cortex and the medulla. (wikipedia.org)
  • Near the medulla is the hilum of lymph node. (wikipedia.org)
  • The primary role of lymph node stromal cells is structural. (wikipedia.org)
  • An adaptive immune response takes place in response to the presence of the antigen in the lymph node. (wikipedia.org)
  • The concentration of S1P in the lymph node is maintained at a level lower than that of the blood or the lymph under the influence of S1P lyase. (wikipedia.org)
  • This means immune cells may leave the lymph node along a chemokine gradient. (wikipedia.org)
  • Lymph node stromal cells express peripheral tissue-restricted antigens (PTAs) on their surface. (wikipedia.org)
  • Drains
  • They receive lymphatic afferents from the following: integument of the penis scrotum perineum buttock abdominal wall below the level of the umbilicus back below the level of the iliac crest vulva anus (below the pectinate line) the thigh and the medial side of the leg (the lateral leg drains to the popliteal lymph nodes first). (wikipedia.org)
  • The right lymphatic duct drains lymph from the right upper limb, right side of thorax and right halves of head and neck. (wikipedia.org)
  • The lateral aortic group drains the iliac lymph nodes, the ovaries, and other pelvic organs. (wikipedia.org)
  • afferent lymph
  • A lymph sinus which includes the subcapsular sinus, is a channel within the node, lined by endothelial cells along with fibroblastic reticular cells and this allows for the smooth flow of lymph through them.The endothelium of the subcapsular sinus is continuous with that of the afferent lymph vessel and is also with that of the similar sinuses flanking the trabeculae and within the cortex. (wikipedia.org)
  • biopsy
  • Sentinel lymph node biopsy for breast cancer: a suitable alternative to routine axillary dissection in multi-institutional practice when optimal technique is used. (springer.com)
  • Comprehensive axillary evaluation in neoadjuvant chemotherapy patients with ltrasonography and sentinel lymph node biopsy. (springer.com)
  • Accuracy of axillary sentinel lymph node biopsy following neoadjuvant (induction) chemotherapy for carcinoma of the breast. (springer.com)
  • If the test comes back malignant they will take some of your lymph nodes to do a biopsy to see how far the cancer has spread so that they can diagnose the stage of the disease. (medhelp.org)
  • My cyst came back as borderline so they took my appendix but no lymph node biopsy. (medhelp.org)
  • The lateral aortic lymph nodes, typically 15 to 20 on each side, are the ones usually chosen for dissection or biopsy in the treatment or diagnosis of cancer. (wikipedia.org)
  • venous
  • Lymph is ultimately returned to the venous circulation . (wikipedia.org)
  • Previously, it was debated whether the lymph sacs developed from the venous system, or if they came from spaces in the mesenchyme, which come together in a centripetal direction and secondarily opened into the veins. (wikipedia.org)
  • Because lymph sacs form from the venous system, they typically contain red blood cells. (wikipedia.org)
  • It is believed that the lymph sacs are directly connected to the venous system and that the venous components and lymphatic components communicate through a small hole. (wikipedia.org)
  • Following the ballooning, there is the process of pinching, which separates the lymph sacs from the venous system. (wikipedia.org)
  • sentinel lymp
  • Can axillary dissection be avoided in patients with sentinel lymph node metastasis? (springer.com)
  • Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla: a study to evaluate the need for complete axillary lymph node dissection. (springer.com)
  • One such node is the Delphian node situated above the isthmus of the thyroid gland, which may be removed at the time of a thyoidectomy as a sentinel lymph node in order to identify risks of cancer spread. (wikipedia.org)
  • 2001
  • Lymph Nodes of the Upper Limb and Breast Trochlea of humerus This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918) clinicalconsiderations at The Anatomy Lesson by Wesley Norman (Georgetown University) Image at umich.edu Image at ucsd.edu Patel D (2001). (wikipedia.org)
  • metastasis
  • Cervical lymph node metastasis is a common feature of papillary thyroid carcinoma Henri Rouvière produced an influential classification in 1938. (wikipedia.org)
  • drain
  • Lymph capillaries or lymphatic capillaries are tiny, thin-walled microvessels located in the spaces between cells (except in the central nervous system and non-vascular tissues ) which serve to drain and process extracellular fluid . (wikipedia.org)
  • The parasternal lymph nodes drain into the bronchomediastinal trunks, in a similar fashion to the upper intercostal lymph nodes. (wikipedia.org)
  • Capillaries
  • Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma proteins in the lymph. (wikipedia.org)
  • The lack of a basal lamina allows lymph capillaries to be more permeable than blood capillaries and, as a consequence, more effective in removing protein-rich fluid from the intercellular spaces. (daviddarling.info)
  • The lymph is formed when the interstitial fluid (the fluid which lies in the interstices of all body tissues) is collected through lymph capillaries. (wikipedia.org)
  • fluid
  • A lymph vessel is a vessel that, unlike a blood vessel , carries fluid only away from tissues . (daviddarling.info)
  • This fluid is a pale, watery substance known as lymph . (daviddarling.info)
  • Lymph is the fluid that circulates throughout the lymphatic system. (wikipedia.org)
  • Since the lymph is derived from the interstitial fluid, its composition continually changes as the blood and the surrounding cells continually exchange substances with the interstitial fluid. (wikipedia.org)
  • Thus, lymph when formed is a watery clear liquid with the same composition as the interstitial fluid. (wikipedia.org)
  • Nodules
  • The lymph node is divided into compartments called lymph nodules (or lobules) each consisting of a cortical region of combined follicle B cells, a paracortical region of T cells, and a basal part of the nodule in the medulla. (wikipedia.org)
  • sacs
  • Lymph sacs are a part of the development of the human lymphatic system, known as lymphangiogenesis. (wikipedia.org)
  • Studies have shown that the development of lymph sacs occurs through swelling and outgrowth of pre-lymphatic clusters from the cardinal vein. (wikipedia.org)
  • These processes begin forming the lymph sacs during the 5th week of fetal development. (wikipedia.org)
  • One week later, during the 6th week of fetal development, four more lymph sacs form. (wikipedia.org)
  • There are many transcription factors that regulate the development of the lymphatic system, particularly the lymph sacs, but in all of the migrating lymphatic endothelial cell precursors, there is one specific factor present, Prospero-related homeobox-1 (PROX1). (wikipedia.org)
  • However, regardless of the presence of these markers, it appears that only the subset of endothelial cells that begin to express Prox1 form the undeveloped lymph sacs. (wikipedia.org)
  • Many experiments involving mice have proven the importance of the Prox1 transcription factor in the development of primitive lymph sacs. (wikipedia.org)
  • skeletal muscle
  • Despite low pressure, lymph movement occurs due to peristalsis (propulsion of the lymph due to alternate contraction and relaxation of smooth muscle tissue), valves, and compression during contraction of adjacent skeletal muscle and arterial pulsation. (wikipedia.org)
  • chyle
  • Likewise, the lymph formed in the human digestive system called chyle is rich in triglycerides (fat), and looks milky white because of its lipid content. (wikipedia.org)
  • cancerous
  • The characterization of cancerous lymph nodes on CT scan, MRI or ultrasound is difficult, and usually requires confirmation by other nuclear imaging techniques such as PET scans. (wikipedia.org)
  • malignant
  • Gross enlargement of the lymph nodes through malignant proliferation of lymph cells characterizes Hodgkin's disease and other forms of lymphoma. (britannica.com)
  • as my mass will most likely be malignant, as they believe this is recurrant GCT, and the Doc did say that she would do staging during the surgery (it wasn't done during my first surgery) does this mean that they will definatly remove some lymph nodes? (medhelp.org)
  • ratio
  • lymph is 38.6 adn the cd4/cd8 ratio is .80 and my WBC count is 2.8 and my Lymphs (absolute) is 0.4. (thebody.com)
  • immune
  • The lymph system is also an important part of the immune system, the body's defense system against disease. (webmd.com)
  • Although the primary function of the lymphatic system is to return proteins and fluids to the blood, this immune function accounts for the tendency of many infections and other disease processes to cause swelling of the lymph nodes. (britannica.com)
  • Before lymph is returned to the blood, it passes through lymph nodes where it is exposed to the cells of the immune system . (daviddarling.info)
  • Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles and cancer cells. (wikipedia.org)