Leiomyosarcoma: A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)Vascular Neoplasms: Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.Uterine Neoplasms: Tumors or cancer of the UTERUS.Smooth Muscle Tumor: A tumor composed of smooth muscle tissue, as opposed to leiomyoma, a tumor derived from smooth muscle.Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Vena Cava, Inferior: The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.Genital Neoplasms, Male: Tumor or cancer of the MALE GENITALIA.Retroperitoneal NeoplasmsMuscle Neoplasms: Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.Heart Neoplasms: Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.Mesenchymoma: A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)Spermatic Cord: Either of a pair of tubular structures formed by DUCTUS DEFERENS; ARTERIES; VEINS; LYMPHATIC VESSELS; and nerves. The spermatic cord extends from the deep inguinal ring through the INGUINAL CANAL to the TESTIS in the SCROTUM.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Renal Veins: Short thick veins which return blood from the kidneys to the vena cava.Liposarcoma: A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)Skull Neoplasms: Neoplasms of the bony part of the skull.Jejunal Neoplasms: Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).Histiocytoma, Malignant Fibrous: The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.

*  Leiomyosarcomas dictionary definition | leiomyosarcomas defined

How would you define leiomyosarcomas? Add your definition here.. Please enable JavaScript to view the comments powered by ... leiomyosarcomas definition: Noun 1. plural form of leiomyosarcoma... ...
yourdictionary.com/leiomyosarcomas

*  A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma | Clinical...

Purpose: Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the ... A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma. Weiwei Shan, ... A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma ... A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma ...
clincancerres.aacrjournals.org/content/early/2012/05/25/1078-0432.CCR-11-3058

*  Leiomyosarcoma Warrior: October 2008

My purpose in starting this blog, is to share my experience with battling Leiomyosarcoma with others. I plan on journaling ... Above all else, I hope that this blog will help other Leiomyosarcoma patients relate their experience to mine and know that ... I am currently battling Leiomyosarcoma and wanted to share my experience and hear from others who are going through the same ...
knockoutcancer.blogspot.com/2008/10/

*  Leiomyosarcoma Warrior: When I got diagnose

After being examined by him and studying my CT-Scan I was diagnosed with Leiomyosarcoma and scheduled to have an operation the ... I am currently battling Leiomyosarcoma and wanted to share my experience and hear from others who are going through the same ...
knockoutcancer.blogspot.com/2008/11/when-i-got-diagnose.html

*  https://www.cancer.gov/types/small-intestine/hp/small-intestine-treatment-pdq

Leiomyosarcomas occur most often in the ileum. Some 20% of malignant lesions of the small intestine are carcinoid tumors, which ... Sarcoma (most commonly leiomyosarcoma and more rarely angiosarcoma or liposarcoma). *Carcinoid. (Refer to the PDQ summary on ... No standard effective chemotherapy exists for patients with recurrent metastatic adenocarcinoma or leiomyosarcoma of the small ... The 5-year survival rate for resectable leiomyosarcoma, the most common primary sarcoma of the small intestine, is ...
https://cancer.gov/types/small-intestine/hp/small-intestine-treatment-pdq

*  DMOZ - Health: Conditions and Diseases: Cancer: Musculoskeletal: Soft Tissue Sarcoma: Leiomyosarcoma

Leiomyosarcoma.info Provides medical information for patients and doctors, including a tutorial, treatment options, support and ... Non-profit entity whose stated aim is to advance treatment and research efforts for leiomyosarcoma patients. ...
dmoztools.net/Health/Conditions_and_Diseases/Cancer/Musculoskeletal/Soft_Tissue_Sarcoma/Leiomyosarcoma/

*  Ribbon for Pancreatic and Leiomyosarcoma Cancer Awareness Indoor Outdoor Throw Pillow | Staples

Buy Ribbon for Pancreatic and Leiomyosarcoma Cancer Awareness Indoor Outdoor Throw Pillow at Staples' low price, or read ... Ribbon for Pancreatic and Leiomyosarcoma Cancer Awareness Indoor/Outdoor Throw Pillow. Item: WYF078278082857Model: AN1207PW1414 ...
https://m.staples.com/Ribbon-for-Pancreatic-and-Leiomyosarcoma-Cancer-Awareness-Indoor-Outdoor-Throw-Pillow/product_WYF078278082857

*  Summary View > Yale Cancer Center | Yale School of...

Leiomyosarcoma . This smooth muscle tumor has been linked with Epstein-Barr virus in children who also have HIV disease or AIDS ... Leiomyosarcoma may also form as a second cancer in survivors of inherited retinoblastoma, sometimes many years after the ...
medicine.yale.edu/cancer/patient/programs/pediatric/info/info.aspx?id=CDR258672

*  Soft tissue sarcoma Causes - Mayo Clinic

Leiomyosarcoma. *Liposarcoma. *Lymphangiosarcoma. *Malignant fibrous histiocytoma. *Malignant peripheral nerve sheath tumor. * ...
mayoclinic.org/diseases-conditions/soft-tissue-sarcoma/basics/causes/con-20033386?mc_id=comlinkpilot&placement=resources

*  Leiomyosarcoma Warrior: When I first diagnosed with cancer

Hi, I'm Clemencia. I am currently battling Leiomyosarcoma and wanted to share my experience and hear from others who are going through the same thing ...
knockoutcancer.blogspot.com/2008/11/when-i-first-diagnosed-with-cancer.html

*  Leiomyosarcoma Warrior: Why I created this site...

My purpose in starting this blog, is to share my experience with battling Leiomyosarcoma with others. I plan on journaling about my drug treatment plans, experiences with treatment side effects and how I deal with those side effects. Plus, I will explain the natural remedies and other advice I have gained throughout the past year and a half ...
knockoutcancer.blogspot.com/2008/10/why-i-created-this-site.html

*  Additional Clinical Trial Resources - Sarcoma Alliance

For more information please visit: http://clinicaltrials.gov/ct2/show/NCT01440088?spons=Threshold&rank=16. A Study of the Safety and Efficacy of the Combination of Gemcitabine and Docetaxel with MORAb-004 in Metastatic Soft Tissue Sarcoma Morphotek is conducting this phase II trail to evaluate the progression-fee survival (PFS) of subjects treated with the combination of gemcitabine and docetaxel plus MORAb-004 versus gemcitabine and docetaxel plus placebo in subjects with metastatic soft tissue sarcome in 4 defined subgroups: liposarcoma, leiomyosarcoma, undifferentiated pleomorphic sarcoma and myxofobrpsarcoma, and other STS. For more information click here.. Trabectedin or Dacarbazine - Janssen Research & Development, L.L.C.. A Study of Trabectedin or Dacarbazine for the Treatment of Patients with Advanced Liposarcoma or Leiomyosarcoma Janssen Research & Development, L.L.C. is conducting a Phase 3 clinical trial for trabectedin or dacarbazine in patients with liposarcoma ...
sarcomaalliance.org/what-you-need-to-know/clinical-trials/additional-clinical-trial-resources/

*  Synchronous coexistence of liver metastases from cecal leiomyosarcoma and rectal adenocarcinoma: A case report

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
pubmedcentralcanada.ca/pmcc/articles/PMC5340824/

*  Leiomyosarcoma Warrior: December 2008

The CT-Scan was not good at all. The 18 tumors in my lungs got bigger; the good news is that there were no new ones. So my doctor recommended that I should try this drugs for lung cancer ( I forgot the name of it.) and the downside is that it's not even approve with the kind of cancer I have, not to mention it's very expensive. I suggested to my doctor what about going back to my original chemo drugs which is gemzar and taxotere; he said that's a good option too. Then I went to see my second opinion doctor he's amazing. I asked him about going back to my original chemo drugs? He agrees with me because we have seen a significant shrinkage in my lung tumors which my first doctor thought was a scarring tissue because the biopsy result was negative. I felt that he drop the ball when it comes to my treatment ...
knockoutcancer.blogspot.com/2008/12/

*  Leiomyosarcoma Warrior

Hi! I'm sorry that I have not written anything this past week, I have been so busy. Today I went to farmers market to buy organic fruits and vegetables, I am preparing to cook some of my comfort food before I go to the hospital to get my chemo, I will be there for five days. This will be my third round of chemo on a third protocol. I'm hoping that this chemo is working for me ...
knockoutcancer.blogspot.com/2008/11/hi-im-sorry-that-i-have-not-written.html

*  Famous last words: Legs eleven

I am 62, retired from running my own events business. I have been married to Stewart for 43 years and have four fantastic children, Sam, Joe, Luke and Jess, four grandchildren, Harry and Danny and new twins, Max and Charlie; I also have two step-grandchildren, Hannah and Chelsea. On 11 September 2009 I was told that the very rare leiomyosarcoma that was found in one of my veins in summer 2008, and removed, had metastasised and I now have sarcomas in my lungs. By April 2010 it had got to my liver and back to my leg. In January sarcoma nodules were found on the horse's tail, the bunch of nerves that come out of the base of my spine. Despite radiotherapy, the paralysis spread very quickly and I have no feeling at all from my hips down. I will try to log what all this feels like in this blog and keep in touch with friends, family and fellow travellers along the way ...
famouslastwordsjt.blogspot.com/2011/04/legs-eleven.html

*  Famous last words: A treat a day

I am 62, retired from running my own events business. I have been married to Stewart for 43 years and have four fantastic children, Sam, Joe, Luke and Jess, four grandchildren, Harry and Danny and new twins, Max and Charlie; I also have two step-grandchildren, Hannah and Chelsea. On 11 September 2009 I was told that the very rare leiomyosarcoma that was found in one of my veins in summer 2008, and removed, had metastasised and I now have sarcomas in my lungs. By April 2010 it had got to my liver and back to my leg. In January sarcoma nodules were found on the horse's tail, the bunch of nerves that come out of the base of my spine. Despite radiotherapy, the paralysis spread very quickly and I have no feeling at all from my hips down. I will try to log what all this feels like in this blog and keep in touch with friends, family and fellow travellers along the way ...
famouslastwordsjt.blogspot.com/2010/06/treat-day.html

*  Famous last words: Filling my life

I am 62, retired from running my own events business. I have been married to Stewart for 43 years and have four fantastic children, Sam, Joe, Luke and Jess, four grandchildren, Harry and Danny and new twins, Max and Charlie; I also have two step-grandchildren, Hannah and Chelsea. On 11 September 2009 I was told that the very rare leiomyosarcoma that was found in one of my veins in summer 2008, and removed, had metastasised and I now have sarcomas in my lungs. By April 2010 it had got to my liver and back to my leg. In January sarcoma nodules were found on the horse's tail, the bunch of nerves that come out of the base of my spine. Despite radiotherapy, the paralysis spread very quickly and I have no feeling at all from my hips down. I will try to log what all this feels like in this blog and keep in touch with friends, family and fellow travellers along the way ...
famouslastwordsjt.blogspot.com/2011/03/filling-my-life.html

*  December | 2015 | Thriver Soup

Once the soul awakens, the search begins and you can never go back.. John O'Donohue. The soul of Patricia Moreira-Cali has been stirred into full life by a purple dragon known as leiomyosarcoma. It is a rare and aggressive form of cancer, and for women it usually starts in the uterus.. On April 23, 2013, Patricia's uterine "fibroids" were found to be cancerous, and she began a perilous journey that continues today. She bravely talks about her first year after the diagnosis in her book, My Journey with the Purple Dragon. She goes into vulnerable detail about her emotional experiences and her search for a cure.. "Friends and family are not with you at all times of the day and night," she wrote. "You are alone when the tears seem endless, when the sorrow is so painful that it's hard to breathe, when the grief cuts through your core, when you long for the freedom to feel healthy, and when you are introduced to death, and somehow you befriend it.". She experiments with a variety of complementary ...
thriversoup.com/2015/12/

(1/527) Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma.

Distinction of malignant uterine leiomyosarcomas from benign leiomyomas by morphological criteria is not always possible. Leiomyosarcomas typically have complex cytogenetic abnormalities; in contrast, leiomyomas have simple or no cytogenetic abnormalities. To understand better the biological distinction(s) between these tumors, we analyzed two other potential markers of genomic instability, loss of heterozygosity (LOH) and microsatellite instability. We examined archival materials from 16 leiomyosarcomas and 13 benign leiomyomas by polymerase chain reaction for 26 microsatellite polymorphisms. Markers were selected based on previous reports of cytogenetic or molecular genetic abnormalities in leiomyosarcomas or leiomyomas and surveyed chromosomes 7, 9, 10, 11, 12, 14, 15, 16, 18, 21, and X. LOH for markers on chromosomes 15, 18, 21, and X was infrequent in leiomyosarcomas (1 of 6 tumors for each chromosome) and not observed for markers on chromosomes 7, 9, 11, 12, 14, or 16. Interestingly, 8 of 14 (57.2%) informative leiomyosarcomas had LOH for at least one marker on chromosome 10 and involved both chromosomal arms in 45.5% (5 of 11). In contrast to leiomyosarcomas, LOH for chromosome 10 was not found in 13 benign leiomyomas. Microsatellite instability was found infrequently in leiomyosarcomas and not detected in leiomyoma. Clinicopathological features (eg, atypia, necrosis, and clinical outcome) did not appear to correlate with LOH for chromosome 10. In contrast to other chromosomes studied, LOH on chromosome 10 was frequent in leiomyosarcomas and absent in benign leiomyomas.  (+info)

(2/527) Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS.  (+info)

(3/527) Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma.

BACKGROUND: Calponin h1, a basic actin-binding protein capable of inhibiting smooth muscle contraction, is a constitutive element of smooth muscle cells. However, in leiomyosarcoma (a type of smooth muscle neoplasm of the uterus), reduced expression of calponin h1 is observed, as we have reported previously. In this study, we sought to assess the effects (in vitro and in vivo) of increasing calponin h1 expression in leiomyosarcoma cells. METHODS: A plasmid containing a human calponin h1 complementary DNA and a bacterial neomycin-resistance gene was transfected into the human leiomyosarcoma cell lines SKN and SK-LMS-1 by electroporation. Southern blotting, reverse transcription-polymerase chain reaction analysis, western blotting, and immunohistochemistry were used to confirm DNA transfer and expression of the calponin h1 protein in neomycin-resistant clones. We characterized the morphology of calponin h1-transfected cells, and we evaluated their proliferative activity and tumorigenicity by use of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, an anchorage-independent growth assay, and a nude mouse tumorigenicity assay. RESULTS: The morphology of calponin h1-transfected cells in culture resembled that of cultured normal myometrial smooth muscle cells. With SK-LMS-1 cells, proliferation of calponin h1-transfection cells was reduced to 69% of control; with SKN cells, calponin h1 transfection reduced proliferation to 70% of control. In assays of anchorage-independent growth and in vivo tumorigenicity, both growth and tumorigenicity were statistically significantly reduced in calponin h1-transfected leiomyosarcoma cells. CONCLUSIONS: Calponin h1 may function as a tumor suppressor in leiomyosarcoma. Clinically, transfer of a calponin h1 complementary DNA into poorly differentiated leiomyosarcoma cells may be of potential therapeutic value through induction of a normal, differentiated cellular phenotype.  (+info)

(4/527) Cerebral metastasis of a uterine leiomyosarcoma--case report.

A 38-year-old female presented with sudden neurological deterioration 6 years after an operation and chemotherapy for uterine leiomyosarcoma. An extremely rare metastasis of the uterine leiomyosarcoma to the brain was identified and totally resected. Whole brain irradiation (50 Gy) was given. A recurrence of the metastasis was resected 10 weeks later. She ultimately died of a second recurrence. Aggressive surgical management of cerebral metastasis of uterine leiomyosarcoma may achieve an improved outcome.  (+info)

(5/527) Leiomyosarcoma of the esophagus in a patient with chagasic megaesophagus: case report and literature review.

Leiomyosarcoma constitutes approximately 0.5% of the malignant neoplasias of the esophagus and its association with megaesophagus has not been described. We report on a case of a woman with dysphagia that was slowly progressive from the age of 19 due to chagasic megaesophagus. The woman was subjected to cardiomyotomy at the age of 49. She presented a rapid worsening of the dysphagia due to leiomyosarcoma at the age of 61, and was subjected to subtotal esophagectomy with cervical esophagogastroplasty. She developed pulmonary and hepatic metastases 14 months after surgery and died six months later.  (+info)

(6/527) "Mesenchymal tumor" or "decidual-like reaction"?

For more than 40 yr, an unusual urinary bladder lesion has been known to occur in certain strains of mice, but no consensus has been obtained regarding its etiology, pathogenesis, biology, or classification. The lesion was first assumed to be epithelial and non-neoplastic, then it was called a smooth muscle cell tumor or leiomyosarcoma because of ultrastructural characteristics for smooth muscle cells. Later, the nonspecific term "mesenchymal tumor" was introduced due to histomorphologic differences from all smooth muscle tumors known. Recently, a proposal was made to name it "decidual-like reaction" because of the histomorphologic similarity to the rare spontaneous decidual reaction in the uterus of aging mice. Both lesions are characterized by spindle and large pleomorphic epithelioid cells with large bizarre nuclei; these characteristics mimic anaplasia of malignant tumors and led pathologists to assume a neoplastic nature. The decidual hypothesis is supported by the regular presence of nuclear progesterone receptors, the occasional occurrence of eosinophilic cytoplasmic granules, the rare finding of cells morphologically resembling granulated metrial gland cells (all also observed in the uterine decidual reaction), and the reproducibility through long-term feeding of combinations of estrogens and progestogens. It appears that the new decidual hypothesis can explain many detailed facets of the lesion, with the exception of the reported smooth muscle cell characteristics. The controversy of "mesenchymal tumor versus decidual-like reaction" should be resolved soon, not only as a scientific issue, but also because of consequences for risk assessment.  (+info)

(7/527) Correlation between clinicopathological features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP study group.

Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far, however, data regarding sarcomas of monomorphic spindle cell type have been limited and somewhat disappointing, with the notable exception of synovial sarcoma. As part of an ongoing international collaborative study, 130 karyotyped spindle-cell sarcomas were reviewed and classified histologically, without knowledge of the clinical and karyotypic data, with the aim of identifying objective correlations between morphology, karyotype, and clinical parameters. Clonal chromosomal abnormalities were identified in 82 cases studied (63%), but only in the group of synovial sarcomas was there clear correlation between the cytogenetic findings, in the form of a consistent t(X;18)(p11;q11), and morphology. Among leiomyosarcomas (41 cases) and malignant peripheral nerve sheath tumors (MPNSTs; 27 cases) as well as in individual examples of rarer entities, there was a general tendency for karyotypic complexity associated with frequent loss or rearrangement of chromosome arms 1p, 10p, 11q, 12q, 17p, and 22q. Rearrangements of 17q (the region of the NF1 gene) were seen in 9/27 (33%) of MPNSTs. Among nine cases of solitary fibrous tumor (in which previous cytogenetic data are very limited) no consistent aberrations were identified. We conclude that, with the exception of synovial sarcoma, most spindle-cell sarcomas share with pleomorphic sarcomas the tendency for karyotypic complexity. There was no indication (in most of these lesions) that detectable cytogenetic aberrations could either facilitate their diagnosis or help to determine prognosis. There is a clear need to further study and understand the significance of multiple chromosomal abnormalities in this group of mesenchymal neoplasms with the particular goal of determining their role in the process of tumor development.  (+info)

(8/527) Prognostic significance of bcl-2 expression in leiomyosarcoma of the uterus.

We examined bcl-2 expression as well as p53 expression and mutation in human uterine smooth muscle tumours to determine the influence of bcl-2 expression on prognosis in patients with uterine leiomyosarcomas. bcl-2 protein was expressed in nearly all benign smooth muscle tumours but in only 57% of leiomyosarcomas. Benign smooth muscle tumours were usually negative for p53 protein, but 16 out of 21 (76%) leiomyosarcomas were positive. A p53 gene mutation was detected in nine of the 16 leiomyosarcomas that showed p53-positive staining. A significant positive correlation was observed between p53 mutation and p53 expression, between the number of mitoses and the Ki-67 labelling index, and between clinical stage and p53 mutation. A significant negative correlation was observed between bcl-2 expression and p53 mutation, and between bcl-2 expression and p53 overexpression. Univariate survival analysis revealed that bcl-2 expression, p53 mutation and clinical stage (stage 1 vs stages 2-4) all showed a significant correlation with prognosis. In a multivariate stepwise regression analysis, positive bcl-2 expression and stage 1 disease were the independent predictors of a favourable prognosis. Our results suggest that bcl-2 is frequently expressed in human uterine smooth muscle tumours, and that its expression may correlate with a favourable prognosis in patients with uterine leiomyosarcoma.  (+info)



Uterine Leiomyosarcoma


  • Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. (aacrjournals.org)

liposarcoma


  • Sarcoma (most commonly leiomyosarcoma and more rarely angiosarcoma or liposarcoma). (cancer.gov)

primary


patients


  • Above all else, I hope that this blog will help other Leiomyosarcoma patients relate their experience to mine and know that they are not alone in fighting this rare disease. (blogspot.com)
  • Non-profit entity whose stated aim is to advance treatment and research efforts for leiomyosarcoma patients. (dmoztools.net)

next


  • After being examined by him and studying my CT-Scan I was diagnosed with Leiomyosarcoma and scheduled to have an operation the very next week. (blogspot.com)

share


  • My purpose in starting this blog, is to share my experience with battling Leiomyosarcoma with others. (blogspot.com)
  • I am currently battling Leiomyosarcoma and wanted to share my experience and hear from others who are going through the same thing. (blogspot.com)