Lead Radioisotopes
Radioisotopes
Zinc Radioisotopes
Radioisotope Dilution Technique
Strontium Radioisotopes
Iodine Radioisotopes
Krypton Radioisotopes
Indium Radioisotopes
Thorium
Thorium Dioxide
Uranium
Actinium
Radioactivity
Comparative cellular catabolism and retention of astatine-, bismuth-, and lead-radiolabeled internalizing monoclonal antibody. (1/24)
Monoclonal antibodies (mAbs) labeled with alpha-emitting radionuclides such as (211)At, (212)Bi, (213)Bi, and (212)Pb (which decays by beta-emission to its alpha-emitting daughter, (212)Bi) are being evaluated for their potential applications for cancer therapy. The fate of these radionuclides after cells are targeted with mAbs is important in terms of dosimetry and tumor detection. METHODS: In this study, we attached various radionuclides that result in alpha-emissions to T101, a rapidly internalizing anti-CD5 mAb. We then evaluated the catabolism and cellular retention and compared them with those of (125)I- and (111)In-labeled T101. T101 was labeled with (211)At, (125)I, (205,6)Bi, (111)In, and (203)Pb. CD5 antigen-positive cells, peripheral blood mononuclear cells (PBMNC), and MOLT-4 leukemia cells were used. The labeled T101 was incubated with the cells for 1 h at 4 degrees C for surface labeling. Unbound activity was removed and 1 mL medium added. The cells were then incubated at 37 degrees C for 0, 1, 2, 4, 8, and 24 h. The activity on the cell surface that internalized and the activity on the cell surface remaining in the supernatant were determined. The protein in the supernatant was further precipitated by methanol for determining protein-bound and non-protein-bound radioactivity. Sites of internal cellular localization of radioactivity were determined by Percoll gradient centrifugation. RESULTS: All radiolabeled antibodies bound to the cells were internalized rapidly. After internalization, (205,6)Bi, (203)Pb, and (111)In radiolabels were retained in the cell, with little decrease of cell-associated radioactivity. However, (211)At and (125)I were released from cells rapidly ((211)At < (125)I) and most of the radioactivity in the supernatant was in a non-protein-bound form. Intracellular distribution of radioactivity revealed a transit of the radiolabel from the cell surface to the lysosome. The catabolism patterns of MOLT-4 cells and PBMNC were similar. CONCLUSION: (211)At catabolism and release from cells were somewhat similar to that of (125)I, whereas (205,6)Bi and (203)Pb showed prolonged cell retention similar to that of (111)In. These catabolism differences may be important in the selection of alpha-radionuclides for radioimmunotherapy. (+info)Molecular tracers of saturated and polycyclic aromatic hydrocarbon inputs into Central Park Lake, New York City. (2/24)
Saturated hydrocarbons (SH) and polycyclic aromatic hydrocarbons (PAHs) have been quantified in a sediment core obtained from Central Park Lake, New York City. Radionuclides 210Pb and 137Cs were used to assign approximate dates to each individual section in the core. The dating profile based on 210Pb matches very well with the time constraints provided by 137Cs. Radionuclide-derived depositional dates are consistent with temporal information from the petroleum-indicator ratio U/R [the ratio of unresolved complex mixture (UCM)to saturated hydrocarbons in the aliphatic fraction] and the history of fuel use in the NYC area. Ratios of 1,7-dimethylphenanthrane (DMP) to 1,7-DMP plus 2,6-DMP [1,7/(1,7 + 2,6)-DMP], retene to retene plus chrysene [Ret/(Ret + Chy)], and fluoranthene to fluoranthene plus pyrene [FI/(FI + Py)] provide additional source discrimination throughoutthe core. Results show that the ratio U/R is sensitive to petroleum inputs and Ret/(Ret + Chy) is responsive to contributions from softwood combustion, whereas both FI/(FI + Py) and 1,7/ (1,7 + 2,6)-DMP can be used to discriminate among wood, coal, and petroleum combustion sources. Combined use of these ratios suggests that in New York City, wood combustion dominated 100 years ago, with a shift to coal combustion occurring from the 1900s to the 1950s. Petroleum use began around the 1920s and has dominated since the 1940s. (+info)Potentiation of high-LET radiation by gemcitabine: targeting HER2 with trastuzumab to treat disseminated peritoneal disease. (3/24)
PURPOSE: Recent studies from this laboratory with (212)Pb-trastuzumab have shown the feasibility of targeted therapy for the treatment of disseminated peritoneal disease using (212)Pb as an in vivo generator of (212)Bi. The objective of the studies presented here was improvement of the efficacy of alpha-particle radioimmunotherapy using a chemotherapeutic agent. EXPERIMENTAL DESIGN: In a series of experiments, a treatment regimen was systematically developed in which athymic mice bearing i.p. LS-174T xenografts were injected i.p. with gemcitabine at 50 mg/kg followed by (212)Pb radioimmunotherapy. RESULTS: In a pilot study, tumor-bearing mice were treated with gemcitabine and, 24 to 30 h later, with 5 or 10 muCi (212)Pb-trastuzumab. Improvement in median survival was observed at 5 microCi (212)Pb-trastuzumab in the absence (31 days) or presence (51 days) of gemcitabine: 45 and 70 days with 10 microCi versus 16 days for untreated mice (P < 0.001). Multiple doses of gemcitabine combined with a single (212)Pb radioimmunotherapy (10 microCi) administration was then evaluated. Mice received three doses of gemcitabine: one before (212)Pb-trastuzumab and two afterwards. Median survival of mice was 63 versus 54 days for those receiving a single gemcitabine dose before radioimmunotherapy (P < 0.001), specifically attributable to (212)Pb-trastuzumab (P = 0.01). Extending these findings, one versus two treatment cycles was compared. A cycle consisted of sequential treatment with gemcitabine, 10 microCi (212)Pb radioimmunotherapy, then one or two additional gemcitabine doses. In the first cycle, three doses of gemcitabine resulted in a median survival of 90 versus 21 days for the untreated mice. The greatest benefit was noted after cycle 2 in the mice receiving 10 microCi (212)Pb-trastuzumab and two doses of gemcitabine with a median survival of 196.5 days (P = 0.005). Pretreatment of tumor-bearing mice with two doses of gemcitabine before (212)Pb radioimmunotherapy was also assessed with gemcitabine injected 72 and 24 h before (212)Pb-trastuzumab. The median survival was 56 and 76 days with one and two doses of gemcitabine versus 49 days without gemcitabine. The effect may not be wholly specific to trastuzumab because (212)Pb-HuIgG with two doses of gemcitabine resulted in a median survival of 66 days (34 days without gemcitabine). CONCLUSIONS: Treatment regimens combining chemotherapeutics with high-LET targeted therapy may have tremendous potential in the management and care of cancer patients. (+info)203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection. (4/24)
(+info)210Pb: a predictive biomarker of retrospective cigarette smoke exposure. (5/24)
(+info)Towards translation of 212Pb as a clinical therapeutic; getting the lead in! (6/24)
(+info)An assessment of radioactivity levels of 210Pb and 40K in tobacco and radiation exposure from smoking. (7/24)
No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics. (+info)Long-term responses of rainforest erosional systems at different spatial scales to selective logging and climatic change. (8/24)
(+info)Lead radioisotopes refer to specific types of radioactive isotopes (or radionuclides) of the element lead. These isotopes have unstable nuclei and emit radiation as they decay over time, changing into different elements in the process. Examples of lead radioisotopes include lead-210, lead-212, and lead-214. These isotopes are often found in the decay chains of heavier radioactive elements such as uranium and thorium, and they have various applications in fields like nuclear medicine, research, and industrial radiography. However, exposure to high levels of radiation from lead radioisotopes can pose significant health risks, including damage to DNA and increased risk of cancer.
Radioisotopes, also known as radioactive isotopes or radionuclides, are variants of chemical elements that have unstable nuclei and emit radiation in the form of alpha particles, beta particles, gamma rays, or conversion electrons. These isotopes are formed when an element's nucleus undergoes natural or artificial radioactive decay.
Radioisotopes can be produced through various processes, including nuclear fission, nuclear fusion, and particle bombardment in a cyclotron or other types of particle accelerators. They have a wide range of applications in medicine, industry, agriculture, research, and energy production. In the medical field, radioisotopes are used for diagnostic imaging, radiation therapy, and in the labeling of molecules for research purposes.
It is important to note that handling and using radioisotopes requires proper training, safety measures, and regulatory compliance due to their ionizing radiation properties, which can pose potential health risks if not handled correctly.
Zinc radioisotopes are unstable isotopes or variants of the element zinc that undergo radioactive decay, emitting radiation in the process. These isotopes have a different number of neutrons than the stable isotope of zinc (zinc-64), which contributes to their instability and tendency to decay.
Examples of zinc radioisotopes include zinc-65, zinc-70, and zinc-72. These isotopes are often used in medical research and diagnostic procedures due to their ability to emit gamma rays or positrons, which can be detected using specialized equipment.
Zinc radioisotopes may be used as tracers to study the metabolism and distribution of zinc in the body, or as therapeutic agents to deliver targeted radiation therapy to cancer cells. However, it is important to note that the use of radioisotopes carries potential risks, including exposure to ionizing radiation and the potential for damage to healthy tissues.
The Radioisotope Dilution Technique is a method used in nuclear medicine to measure the volume and flow rate of a particular fluid in the body. It involves introducing a known amount of a radioactive isotope, or radioisotope, into the fluid, such as blood. The isotope mixes with the fluid, and samples are then taken from the fluid at various time points.
By measuring the concentration of the radioisotope in each sample, it is possible to calculate the total volume of the fluid based on the amount of the isotope introduced and the dilution factor. The flow rate can also be calculated by measuring the concentration of the isotope over time and using the formula:
Flow rate = Volume/Time
This technique is commonly used in medical research and clinical settings to measure cardiac output, cerebral blood flow, and renal function, among other applications. It is a safe and reliable method that has been widely used for many years. However, it does require the use of radioactive materials and specialized equipment, so it should only be performed by trained medical professionals in appropriate facilities.
Strontium radioisotopes are radioactive isotopes of the element strontium. Strontium is an alkaline earth metal that is found in nature and has several isotopes, some of which are stable and some of which are radioactive. The radioactive isotopes of strontium, also known as strontium radionuclides, decay and emit radiation in the form of beta particles.
Strontium-89 (^89Sr) and strontium-90 (^90Sr) are two common radioisotopes of strontium that are used in medical applications. Strontium-89 is a pure beta emitter with a half-life of 50.5 days, which makes it useful for the treatment of bone pain associated with metastatic cancer. When administered, strontium-89 is taken up by bones and irradiates the bone tissue, reducing pain and improving quality of life in some patients.
Strontium-90, on the other hand, has a longer half-life of 28.8 years and emits more powerful beta particles than strontium-89. It is used as a component in radioactive waste and in some nuclear weapons, but it is not used in medical applications due to its long half-life and high radiation dose.
It's important to note that exposure to strontium radioisotopes can be harmful to human health, especially if ingested or inhaled. Therefore, handling and disposal of strontium radioisotopes require special precautions and regulations.
Iodine radioisotopes are radioactive isotopes of the element iodine, which decays and emits radiation in the form of gamma rays. Some commonly used iodine radioisotopes include I-123, I-125, I-131. These radioisotopes have various medical applications such as in diagnostic imaging, therapy for thyroid disorders, and cancer treatment.
For example, I-131 is commonly used to treat hyperthyroidism and differentiated thyroid cancer due to its ability to destroy thyroid tissue. On the other hand, I-123 is often used in nuclear medicine scans of the thyroid gland because it emits gamma rays that can be detected by a gamma camera, allowing for detailed images of the gland's structure and function.
It is important to note that handling and administering radioisotopes require specialized training and safety precautions due to their radiation-emitting properties.
Krypton is a noble gas with the symbol Kr and atomic number 36. It exists in various radioisotopes, which are unstable isotopes of krypton that undergo radioactive decay. A few examples include:
1. Krypton-81: This radioisotope has a half-life of about 2.1 x 10^5 years and decays via electron capture to rubidium-81. It is produced naturally in the atmosphere by cosmic rays.
2. Krypton-83: With a half-life of approximately 85.7 days, this radioisotope decays via beta decay to bromine-83. It can be used in medical imaging for lung ventilation studies.
3. Krypton-85: This radioisotope has a half-life of about 10.7 years and decays via beta decay to rubidium-85. It is produced as a byproduct of nuclear fission and can be found in trace amounts in the atmosphere.
4. Krypton-87: With a half-life of approximately 76.3 minutes, this radioisotope decays via beta decay to rubidium-87. It is not found naturally on Earth but can be produced artificially.
It's important to note that while krypton radioisotopes have medical applications, they are also associated with potential health risks due to their radioactivity. Proper handling and safety precautions must be taken when working with these substances.
Indium radioisotopes refer to specific types of radioactive indium atoms, which are unstable and emit radiation as they decay. Indium is a chemical element with the symbol In and atomic number 49. Its radioisotopes are often used in medical imaging and therapy due to their unique properties.
For instance, one commonly used indium radioisotope is Indium-111 (^111In), which has a half-life of approximately 2.8 days. It emits gamma rays, making it useful for diagnostic imaging techniques such as single-photon emission computed tomography (SPECT). In clinical applications, indium-111 is often attached to specific molecules or antibodies that target particular cells or tissues in the body, allowing medical professionals to monitor biological processes and identify diseases like cancer.
Another example is Indium-113m (^113mIn), which has a half-life of about 99 minutes. It emits low-energy gamma rays and is used as a source for in vivo counting, typically in the form of indium chloride (InCl3) solution. This radioisotope can be used to measure blood flow, ventilation, and other physiological parameters.
It's important to note that handling and using radioisotopes require proper training and safety measures due to their ionizing radiation properties.
Thorium is not a medical term, but it is a chemical element with symbol Th and atomic number 90. It's a naturally occurring, slightly radioactive metal that is found in small amounts in soil, rocks, and water. While thorium has no direct medical applications or definitions, it is worth noting that it has been studied for its potential use in nuclear medicine due to its alpha-emitting properties. However, the use of thorium in medical applications remains highly experimental and not widely adopted.
Thorium dioxide, also known as thorium(IV) oxide or Thorotrast, is a radioactive compound with the chemical formula ThO2. It is a white, odorless, tasteless powder that is insoluble in water and most organic solvents.
Thorium dioxide was historically used as a contrast agent for X-ray radiography, particularly for angiography and myelography, due to its high density and radioopacity. However, its use has been discontinued in many countries due to the recognition of its harmful health effects. Long-term exposure to thorium dioxide can lead to fibrosis, cancer, and other radiation-induced diseases.
It is important to note that the handling and disposal of thorium dioxide require special precautions due to its radioactivity and potential health hazards.
I'm sorry for any confusion, but "Uranium" is not a medical term. It is a chemical element with the symbol "U" and atomic number 92. Uranium is a dense, silvery-gray metal that is hard and brittle at room temperature. It's primarily used as a fuel in nuclear power plants and in the manufacture of weapons.
While uranium does not have direct medical applications, it does pose potential health risks due to its radioactivity. Exposure to high levels of radiation from uranium can lead to acute radiation sickness, anemia, and an increased risk of cancer. However, under normal circumstances, the general public is not exposed to significant amounts of uranium, so it's not a common health concern.
Actinium is a naturally occurring radioactive metallic element with the symbol Ac and atomic number 89. It was discovered in 1899 by André-Louis Debierne, a French chemist, who isolated it from uranium ore. Actinium is one of the actinides, a series of elements in the periodic table that are characterized by their radioactivity and their position in the f-block of the periodic table.
Actinium has no biological role in humans or other organisms, and exposure to its radiation can be harmful. It is not found in significant quantities in the environment, but it can be produced artificially through nuclear reactions. Actinium has a few potential medical applications, including as a component of radioactive compounds used for cancer treatment. However, its use in medicine is limited due to its radioactivity and toxicity.
Radioactivity is not typically considered within the realm of medical definitions, but since it does have medical applications and implications, here is a brief explanation:
Radioactivity is a natural property of certain elements (referred to as radioisotopes) that emit particles or electromagnetic waves due to changes in their atomic nuclei. This process can occur spontaneously without any external influence, leading to the emission of alpha particles, beta particles, gamma rays, or neutrons. These emissions can penetrate various materials and ionize atoms along their path, which can cause damage to living tissues.
In a medical context, radioactivity is used in both diagnostic and therapeutic settings:
1. Diagnostic applications include imaging techniques such as positron emission tomography (PET) scans and single-photon emission computed tomography (SPECT), where radioisotopes are introduced into the body to visualize organ function or detect diseases like cancer.
2. Therapeutic uses involve targeting radioisotopes directly at cancer cells, either through external beam radiation therapy or internal radiotherapy, such as brachytherapy, where a radioactive source is placed near or within the tumor.
While radioactivity has significant medical benefits, it also poses risks due to ionizing radiation exposure. Proper handling and safety measures are essential when working with radioactive materials to minimize potential harm.
In the context of medicine, "lead" most commonly refers to lead exposure or lead poisoning. Lead is a heavy metal that can be harmful to the human body, even at low levels. It can enter the body through contaminated air, water, food, or soil, and it can also be absorbed through the skin.
Lead poisoning occurs when lead builds up in the body over time, causing damage to the brain, nervous system, red blood cells, and kidneys. Symptoms of lead poisoning may include abdominal pain, constipation, fatigue, headache, irritability, memory problems, and in severe cases, seizures, coma, or even death.
Lead exposure is particularly dangerous for children, as their developing bodies are more sensitive to the harmful effects of lead. Even low levels of lead exposure can cause learning disabilities, behavioral problems, and developmental delays in children. Therefore, it's important to minimize lead exposure and seek medical attention if lead poisoning is suspected.
Toxics | Free Full-Text | Use of Radioisotope Ratios of Lead for the Identification of Historical Sources of Soil Lead...
NorthStar Medical Radioisotopes Announces Presentations at Upcoming Jefferies Radiopharma Innovation Summit
CDC Radiation Emergencies | Radioisotope Brief: Uranium-235 (U-235) and Uranium-238 (U-238
Radioisotope thermoelectric generator - Wikipedia
BioDuro-Sundia Radioisotope Laboratory Technology Upgrades Accelerate Innovation - American Biotech News
Cyclotron-produced radioisotopes | Molecular Oncology
Radioisotope Dating and Circular Logic - Revolution Against Evolution
Long-lived radioisotopes (Sr, Nd and U-Th) as tracers for exogene geochemical processes: The importance of particles, colloids...
Online Clinical And Radiological Aspects Of Myopathies: Ct Scanning · Emg · Radioisotopes 1982
NorthStar Medical Radioisotopes Provides Updates on Corporate Progress and Upcoming Milestones | Business Wire
Radioisotopes Bass Rapids, Grand Canyon, Arizona
| Answers in Genesis
Atomic nucleus - New World Encyclopedia
Japan's Triple Disaster - Woods Hole Oceanographic Institution
Radioactive Waste - University of Houston
Radiation Studies - CDC: Properties of Radioactive Isotopes
DOTmed News Search: John%20R.%20Fischer
Radionuclide - Wikipedia
D Russell Humphreys cv
UN Nuke Inspectors Leave For Key Talks In Tehran | Salon.com
page2 boron powder Leading local media on chemical materials, nano-ma
Medical Device Development for Medtech | CPI
Basic Physics of Nuclear Medicine/Interaction of Radiation with Matter - Wikibooks, open books for an open world
Horses Skin Melt Off in California- Fukushima? People Are Next? | Prophecy | Before It's News
PDF) Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomised, multicentre, placebo-controlled...
Phytoremediation: A Novel Strategy for the Removal of Toxic Metals from the Environment Using Plants | Nature Biotechnology
Putting new tools in the hands of leading Canadian scientists | Canada Foundation for Innovation
New higher-capacity cyclotron to stabilize isotope supply
Radiological Weapons Archives - Federation of American Scientists
The following is mirrored from its source at
NorthStar Medical Radioisotopes5
- NorthStar Medical Radioisotopes , LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic and medical imaging applications, today announced that it will be presenting at the upcoming Jefferies Radiopharma Innovation Summit. (tmcnet.com)
- NorthStar continues to expand our leadership position in the rapidly growing area of therapeutic and diagnostic radioisotopes, radiopharmaceuticals, and radiopharmaceutical contract development manufacturing organization (CDMO/CMO) services," said Stephen Merrick, President and Chief Executive Officer of NorthStar Medical Radioisotopes. (tmcnet.com)
- NorthStar Medical Radioisotopes is a commercial-stage nuclear medicine company focused on advancing patient care by providing diagnostic and therapeutic radioisotopes, novel radiopharmaceuticals and customized radiopharmaceutical development services. (tmcnet.com)
- BUSINESS WIRE )-- NorthStar Medical Radioisotopes , LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic and medical imaging applications, today announced a corporate update highlighting progress across its key programs during the past twelve months, and indicating important upcoming milestones. (businesswire.com)
- NorthStar's industry-leading reputation is grounded in technological innovation, successful execution and proven expertise, and we have made tremendous strides in advancing our portfolio over the past year," said Stephen Merrick, Chief Executive Officer of NorthStar Medical Radioisotopes. (businesswire.com)
Radiation3
- The best way to protect against neutron radiation is by providing shielding with thick, heavy materials such as lead, concrete, rock, or dirt. (cdc.gov)
- X‑ray imaging for testing and development in a controlled lead-lined radiation suite. (uk-cpi.com)
- Increased presence in the environment, ease of entry into the food chain, nuclear medicine applications, and the possibility of radiological terrorism incidents can lead to human intake of these radionuclides (Radionuclides/Radiation Protection/US EPA (2020). (cdc.gov)
Radioactive10
- A radioisotope thermoelectric generator (RTG, RITEG), sometimes referred to as a radioisotope power system (RPS), is a type of nuclear battery that uses an array of thermocouples to convert the heat released by the decay of a suitable radioactive material into electricity by the Seebeck effect. (wikipedia.org)
- Suppose that, in step 8), the Lead-206 got there some other way than by radioactive decay. (rae.org)
- Radioactive fallout has led to permanent evacuation of a 300-square-mile area around and northwest of the plant, rendering another 150,000 people homeless. (whoi.edu)
- They must provide adequate radioactive material labeled receptacles for each radioisotope and type of radioactive waste generated. (uh.edu)
- Radioactive waste must be segregated by radioisotope and physical form. (uh.edu)
- Plastic source vial containers, but not the lead impregnated type, may be disposed in the solid waste after being defaced of all radioactive labels. (uh.edu)
- A radionuclide ( radioactive nuclide , radioisotope or radioactive isotope ) is a nuclide that has excess nuclear energy, making it unstable. (wikipedia.org)
- For an in-depth assessment of the radioisotopes of security concern and the commercial radioactive source industry, see the January 2003 report "Commercial Radioactive Sources: Surveying the Security Risks," by myself, Tahseen Kazi, and Judith Perrera. (fas.org)
- In the days leading up to liftoff, engineers will install Curiosity's nuclear power source: a radioisotope thermoelectric generator, which produces electricity from the heat of plutonium-238's radioactive decay. (space.com)
- The Radioactive Orchestra comprises 3175 radioisotopes. (medicallessons.net)
Technetium-99m2
- This paper discusses radioisotope pharmaceutical licensing and provides background information on the manufacturing process, supply chain, and how royalties are developed, using the radioisotope Molybdenum- 99, which decays into technetium-99m, as an example. (lesi.org)
- Technetium-99m is the world's leading isotope for medical imaging. (lesi.org)
Decay4
- It is therefore argued that only changing radioisotope decay rates in the past could account for these discordant isochron 'ages' for the same geologic event. (answersingenesis.org)
- Lead has the highest atomic number of any stable element and concludes three major decay chains of heavier elements. (wikiversity.org)
- Young-earth creationist scientists acknowledge that if the radiometric decay rates are constant or even approximately constant, then both the universe and Earth must be billions of years old (see the Radioisotopes and the Age of the Earth or RATE books published by the Institute of Creation Research and the Creation Research Society). (reasons.org)
- There is no natural source of lead other than the radiometric decay of heavier-than-lead radioisotopes. (reasons.org)
Tweet1
- For the weekend - A tweet led me to a fantastically inventive kind of music. (medicallessons.net)
Positron emission t2
- We present some of the facts that led to development of the nuclear medicine image technology, as well as the general characteristics of single photon emission computed tomography and positron emission tomography. (sld.cu)
- In positron emission tomography (PET), the use of ionizing radioisotopes is required. (lu.se)
Therapeutic5
- Our company is poised to bethe first commercial-scale producer of therapeutic radioisotopes copper-67 and non-carrier added (n.c.a.) actinium-225, and we are strongly positioned for continued rapid growth. (tmcnet.com)
- It is expanding its industry-leading position in the growing area of therapeutic radioisotopes, used in targeted radiopharmaceutical therapy to treat cancer and other serious diseases, and is poised to be the first commercial-scale producer of non-carrier added (n.c.a.) actinium-225 (Ac-225) and copper-67 (Cu-67). (tmcnet.com)
- NorthStar is poised to be the first commercial-scale producer of therapeutic radioisotopes Cu-67 and non-carrier added (n.c.a. (businesswire.com)
- DESCRIPTION (provided by applicant): This proposal outlines a body of research to evaluate the cytotoxicity and therapeutic efficacy of radiolabeled alpha-melanocyte stimulating hormone (a-MSH) peptide analogs that target a-particle emitting radioisotopes to the nuclei of melanoma cells. (sbir.gov)
- In mice, the modified E. coli selectively colonized solid tumors and attracted a therapeutic radioisotope that had been delivered systemically. (aacr.org)
Scanning2
- 75 or 88 or 107, speaking as we find 1675 substances( online Clinical and Radiological Aspects of Myopathies: CT Scanning · EMG · Radioisotopes 1982. (ballroomchicago.com)
- This online Clinical and Radiological Aspects of Myopathies: CT Scanning · EMG · Radioisotopes 1982 is Apocrypha to the video century of the political ice through an textual n. of sites between East and West, South and North. (ballroomchicago.com)
Stable3
- The largest known complete stable nucleus is lead-208 which contains 208 neutrons and protons. (newworldencyclopedia.org)
- For example, uranium-238 ultimately transforms into a stable atom of lead. (cdc.gov)
- This process continues and eventually ends when stable isotopes of bismuth and lead are formed. (cdc.gov)
NorthStar's1
- NorthStar's molybdenum-99 (Mo-99) program is the sole source of domestic Mo-99, used to generate the standard-of-care diagnostic imaging radioisotope for assessing heart disease and cancer. (tmcnet.com)
Producer1
- RIAR is a leading producer and supplier of a wide range of radioisotopes for medical, industrial and other purposes. (niiar.ru)
Radionuclides3
- SHANGHAI , Nov. 15, 2023 /PRNewswire/ - Radioisotope assays a microanalytical method that uses radionuclides as tracers to label research objects. (diwou.com)
- Elements heavier than lead , and the elements technetium and promethium , exist only as radionuclides. (wikipedia.org)
- The information is needed,' she says, 'so that any subsequent efforts to understand the severity of the releases, the bioaccumulation of radionuclides in the ocean food web, and ocean processes and spreading patterns of the released radioisotopes, all have good baseline data. (nsf.gov)
Generating electricity1
- Iran says its program is for peaceful purposes - generating electricity and producing medical radioisotopes to treat cancer patients. (salon.com)
Selectively1
- These agreements have the potential to bring novel new treatments to patients with cancer, using radioisotopes to selectively destroy a wide range of cancer cells. (businesswire.com)
Dense1
- It takes a few inches of lead or other dense substance to block gamma rays. (cdc.gov)
Contamination1
- Nuclear industry advancements and growing concerns about environmental contamination and terrorist activity have increased interest in quantifying radioisotopes in environmental and human samples. (cdc.gov)
Cesium2
- In the Goiania case, the gamma-emitting radioisotope was cesium-137 in the chemical form of cesium chloride, which is a salt-like substance. (fas.org)
- A result of the loss of electricity, overheating at the power plant led to significant releases of iodine, cesium and other radioisotopes to the environment. (nsf.gov)
Forefront1
- Its proven management team and state-of-the-art, environmentally preferable and non-uranium based technologies have made it an emerging leader at the forefront of U.S. medical radioisotope and radiopharmaceutical production. (tmcnet.com)
Medical3
- Quality is assured - we hold EN ISO 13485 , the quality management system required for medical devices, in order produce high quality, compliant products. (uk-cpi.com)
- two leading providers are IBA Group and Best Medical International and Best Cyclotron Systems. (pharmaceuticalcommerce.com)
- 2009). Indium radioisotopes are also widely used in medical research and therapy (Fowler 2007). (who.int)
Zinc2
- Hyperaccumulation of lead and zinc by two metallophytes from mining areas in Central Europe. (nature.com)
- Since the publication of Monograph 86, production of indium compounds has increased but appears limited by the low rate of refining indium as a byproduct of zinc and lead-zinc smelting (Hageluken 2006). (who.int)
Tracers1
- Long-lived radioisotopes (Sr, Nd and U-Th) as tracers for exogene geochemical processes: The importance of particles, colloids and dissolved components for element transport in fresh and brackish water. (dtu.dk)
Copper2
- Removal of copper and lead using a thin-film technique, p. 497-504. (nature.com)
- The solutions, containing parts per million lead and 210pb tracer, are the results of a project on the study of the dissolution behavior of lead- antimony anodes during the electrowinning of copper. (cdc.gov)
Biological2
- Compared with conventional biological sample detection techniques, Radioisotope assay has distinct advantages such as high specificity, high sensitivity at the nanomolar level, short detection time, accurate positioning, and quantification, etc. (diwou.com)
- Lead is a toxin that accumulates in soft tissues and bones, it acts as a neurotoxin damaging the nervous system and interferences with the function of biological enzymes . (wikiversity.org)
Atom1
- A lead atom has 82 electrons , arranged in an electron configuration of [ Xe ]4f 14 5d 10 6s 2 6p 2 . (wikiversity.org)
Uranium4
- For example, Uranium-238 changes into Lead-206. (rae.org)
- 8) Therefore, if a certain mineral contains both Uranium-238 and Lead-206, and if we assume that most of the Lead-206 was derived radiologically, the ratio of these two isotopes should allow an estimate of the fraction of Uranium-238 that had decayed, and since we know the half-life of Uranium-238, we can therefore find how long it took for this process to take place. (rae.org)
- Beyond concerns about the purported weapons work, Washington and its allies want Iran to halt uranium enrichment, which they believe could eventually lead to weapons-grade material and the production of nuclear weapons. (salon.com)
- It has been measured to 4.5662±0.0001 billion years based on the measured decays in primitive meteorites (the building blocks of Earth) of uranium-238, uranium-235, and thorium-232 into lead-206, lead-207, and lead-208, respectively. (reasons.org)
Chemical1
- Lead is a chemical element with the atomic number 82 and the symbol Pb (from the Latin plumbum ). (wikiversity.org)
Production5
- We look forward to sharing information about our innovative and environmentally sustainable approach to radioisotope production with the investor community at this important Jefferies conference. (tmcnet.com)
- We develop the production and the purification of 89 Zr, an appealing PET radioisotope for antibody imaging. (bccrc.ca)
- Lead production declined after the fall of Rome and did not reach comparable levels until the Industrial Revolution . (wikiversity.org)
- In 2014, annual global production of lead was about ten million tonnes, over half of which was from recycling. (wikiversity.org)
- New approaches to radioisotope production using particle accelerators, which are less capital intensive, appear to provide a more efficient and economical method of isotope production. (lesi.org)
Identification1
- The identification and the availability of a radioisotope for radiolabeling with properties and half-life that match with the pharmacokinetic of the radiopharmaceutical is crucial. (bccrc.ca)
Organs1
- This could lead to accumulation and potentially adverse reactions in critical organs such as liver, heart, and even brain, consistent with the hypothesis that ultrafine insoluble particles may play a role in the onset of cardiovas- cular diseases, as growing evidence from epidemiological studies suggests. (cdc.gov)
Excess1
- Here, we present for the first time 210 Pb ex (excess lead-210) and 137 Cs (caesium-137) data of soils from the southeastern TP (SETP) covering an area of 640,000 km 2 . (lu.se)
Acid1
- Radiochemical determination of microgram quantities of lead in acid solutions. (cdc.gov)
Qualities1
- But you'll find in each Monitor news story qualities that can lead to solutions and unite us-qualities such as respect, resilience, hope, and fairness. (csmonitor.com)
Stem cells2
- It was also included application of radioisotope images in the evaluation of biodistribution changes, flow and perfusion in anatomical affected zones by different diseases, in the fields of angiology, orthopedia and cardiology, as a result of the regenerative and proliferative effects induced by stem cells transplant. (sld.cu)
- We mention the radiopharmaceuticals and labelled molecules used in the evaluation of angiogenesis and lymph angiogenesis resulting of cellular therapy and the radioisotopes markers that allow tracking of transplanted stem cells. (sld.cu)
Resistance2
- Studies of pediatric IIH patients have shown elevated sagittal sinus pressure, which could lead to resistance to CSF absorption at the arachnoid villi. (medscape.com)
- Therefore, new methods capable of detecting these subpopulations may lead to better drug resistance surveillance and provide a better tool to predict outcome. (cdc.gov)
Reaction1
- But I don't think it will lead to an immediate reaction. (ratical.org)
Institution1
- The University of Manitoba is the lead institution in Malcolm Xing's project, and a partner in three additional projects led by other institutions. (innovation.ca)
Power1
- As the Director of Space & Planetary Regulation at Zeno Power, Alex oversees regulatory approvals for space launch, maritime, and terrestrial applications of radioisotope power systems. (thebreakthrough.org)
Research4
- BioDuro-Sundia, an Advent International portfolio company, is a trusted, leading contract research development, and manufacturing organization (CRDMO) for over 27 years. (diwou.com)
- The University of Manitoba has a 140-year legacy of leading our province in research, scholarly works and creative activities: this new funding continues that tradition. (innovation.ca)
- Previously, Alex was Project Manager at the Nuclear Innovation Alliance, leading research and advocacy to commercialize advanced nuclear reactors to mitigate climate change. (thebreakthrough.org)
- She has published over 1500 peer reviewed papers and has an internationally leading research profile. (rsc.org)
Cancer3
- Key collaborations with radiochemists at UBC, TRIUMF and the BC Cancer Agency allow developing methods for cyclotron-produced radioisotopes and purification as an attractive and practical substitution of reactors/generators, e.g 44 Sc, 86 Y and 61 Cu 68 Ga or 99m Tc (actually available for patient SPECT imaging). (bccrc.ca)
- DESCRIPTION (provided by applicant): NIH sponsored cancer researchers have been obtaining promising results using molecules radiolabeled with lead-212 in treatment for metastatic melanoma and disseminated colon and pancreatic cancers. (sbir.gov)
- and the second leading cause of cancer death among men in the US. (sbir.gov)
Patients1
- Through radioisotope cisternography, affected patients have also been found to have a 3- to 5-fold decrease in CSF absorption. (medscape.com)
Discovery1
- BioDuro-Sundia's radioisotope laboratory in Jiangsu, China is part of the in vitro biology department of our drug discovery business unit, which mainly provides in vitro pharmacological assays and metabolic assays based on cellular or biochemical reactions. (diwou.com)
Sources1
- Lead (Pb) is an environmental neurotoxicant that has been associated with a wide range of adverse health conditions, and which originates from both anthropogenic and natural sources. (mdpi.com)
Form3
- Use a radioisotope disposal form to document this every time. (uh.edu)
- lead and its oxides react with acids and bases , and it tends to form covalent bonds . (wikiversity.org)
- The principles of determining radioisotope 210pb by liquid scintillation counting were combined with a solvent extraction method for lead using tri-n-octylamine (tnoa) to form a rapid method of analysis of lead containing solutions. (cdc.gov)
Science1
- Jim, one of the leading planetary astronomers of his time and part of the New Horizons scientific collaboration team, passed away last month - a tragic loss for both his family and planetary science. (jhuapl.edu)
Liquid2
- Do not mix liquid scintillation vials, lead pigs, and stock vials with the solid waste, especially sharps. (uh.edu)
- Validation using liquid radioisotopes. (uk-cpi.com)
Mineral3
- However, our new K-Ar, Rb-Sr, Sm-Nd, and Pb-Pb radioisotope data from 11 whole-rock samples (eight diabase, three granophyre) and six mineral phases separated from one of the whole-rock diabase samples yield discordant whole-rock and mineral isochron 'ages. (answersingenesis.org)
- How then are the radioisotope daughters distributed through the granophyre and diabase, and through the mineral phases of the latter? (answersingenesis.org)
- The various radioisotope pairs would be expected to give concordant whole-rock isochron and mineral isochron 'ages. (answersingenesis.org)
Organization1
- Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules). (who.int)
Post-trans1
- Lead is a relatively unreactive post-transition metal . (wikiversity.org)
Patient1
- We are proud to be a leader in expanding the horizons of patient health by providing innovative solutions to ensure robust, reliable access to radioisotopes and radiopharmaceutical products that can make a positive difference in healthcare for people around the world. (businesswire.com)
Release1
- This release does not always lead to exposure. (cdc.gov)
Project1
- The project was led by Dr. Bertram C. Blanke. (wikipedia.org)
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