Labyrinth Diseases: Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS).Vestibule, Labyrinth: An oval, bony chamber of the inner ear, part of the bony labyrinth. It is continuous with bony COCHLEA anteriorly, and SEMICIRCULAR CANALS posteriorly. The vestibule contains two communicating sacs (utricle and saccule) of the balancing apparatus. The oval window on its lateral wall is occupied by the base of the STAPES of the MIDDLE EAR.Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Semicircular Canals: Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Placentation: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.Endolymphatic Duct: The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.Vestibular Diseases: Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.Vestibular Nucleus, Lateral: Vestibular nucleus lying immediately superior to the inferior vestibular nucleus and composed of large multipolar nerve cells. Its upper end becomes continuous with the superior vestibular nucleus.Vestibular Nuclei: The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed)Petrous Bone: The dense rock-like part of temporal bone that contains the INNER EAR. Petrous bone is located at the base of the skull. Sometimes it is combined with the MASTOID PROCESS and called petromastoid part of temporal bone.Caloric Tests: Elicitation of a rotatory nystagmus by stimulating the semicircular canals with water or air which is above or below body temperature. In warm caloric stimulation a rotatory nystagmus is developed toward the side of the stimulated ear; in cold, away from the stimulated side. Absence of nystagmus indicates the labyrinth is not functioning.Vestibular Nerve: The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.Endolymphatic Sac: The blind pouch at the end of the endolymphatic duct. It is a storage reservoir for excess ENDOLYMPH, formed by the blood vessels in the membranous labyrinth.Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Hydrocharitaceae: A plant family of the order Hydrocharitales, subclass ALISMATIDAE, class Liliopsida (monocotyledons).Fenestration, Labyrinth: The surgical creation of a new opening in the labyrinth of the ear for the restoration of hearing in cases of OTOSCLEROSIS. (Dorland, 27th ed)Cochlea: The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.Endolymph: The lymph fluid found in the membranous labyrinth of the ear. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Embryo Loss: Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization.Reflex, Vestibulo-Ocular: A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.Cochlear Diseases: Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Labyrinthitis: Inflammation of the inner ear (LABYRINTH).Vertigo: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)

*  Intratympanic Injection for Autoimmune Inner Ear Disease - Full Text View -

Ear Diseases. Labyrinth Diseases. Labyrinthitis. Otorhinolaryngologic Diseases. Otitis. processed this ... Presence of a demyelinating disease, such as multiple sclerosis. *Women of childbearing potential only: Positive serum ... Intratympanic Injection for Autoimmune Inner Ear Disease (AIED). This study has been terminated. ... Diagnosis of autoimmune inner ear disease (AIED) by the principal investigator. *Idiopathic, bilateral sensorineural hearing ...

*  Effectiveness of Betaserc® (Betahistine Dihydrochloride) in Patients With Vestibular Vertigo in Routine Practice - Full Text...

Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. Neurologic Manifestations. Nervous System Diseases. Signs and ..."Vertigo"&rank=2

*  Vestibular Function Outcome After Cartilage Cap Occlusion Surgery - Full Text View -

Nervous System Diseases. Signs and Symptoms. Vestibular Diseases. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic ..."Dizziness"&rank=11

*  Study of the Effectiveness of Vestibular Stimulation as a Coadjuvant Treatment in Major Depression - Full Text View -...

Vestibular Diseases. Behavioral Symptoms. Mood Disorders. Mental Disorders. Labyrinth Diseases. Ear Diseases. ..."Depression" [DISEASE]&rank=20

*  Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease - Full Text View -...

Meniere Disease. Vestibular Diseases. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. Neurologic ... Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. The disease is ... MedlinePlus related topics: Dizziness and Vertigo Meniere's Disease Drug Information available for: Acyclovir Acyclovir ... Nervous System Diseases. Signs and Symptoms. Endolymphatic Hydrops. Acyclovir. Antiviral Agents. Anti-Infective Agents. ..."Vertigo"&rank=15

*  Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease - Full Text View -

Meniere Disease. Endolymphatic Hydrops. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. Prednisolone acetate. ... Patients with Ménière's disease in later stages (not having vertigo attacks).. *Age: patients older than 70 years at the start ... MedlinePlus related topics: Meniere's Disease Drug Information available for: Methylprednisolone Gentamicin Gentamicin ... Meniere's disease is characterised by episodic spontaneous vertigo attacks with hearing loss, ringing sounds and fullness in ..."Meniere disease"&rank=9

*  Effect of V0251 in Acute Vertigo - Full Text View -

Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. Neurologic Manifestations. Nervous System Diseases. Signs and ...

*  Vestibular Rehabilitation for Strokepatients With Dizziness - Full Text View -

Nervous System Diseases. Signs and Symptoms. Vestibular Diseases. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic ...

*  Labyrinth of Problems: ABORTED "The Origin Of Disease"

OKER es una joven formación madrileña que rinde tributo al HEAVY ROCK que se practicaba en la década de los 80 en España. Es de agradecer ...

*  Nuclear, Plasma, and Radiological Engineering - Research Output - University of Illinois at Urbana-Champaign

Marjanovic, M., Nolan, R. M., Erickson-Bhatt, S. J., Adie, S. G., Chaney, E. J., South, F. A., Monroy, G. L., Shemonski, N. D., Shelton, R. L., Bower, A. J., Simpson, D. G., Ray, P. S., Cradock, K. A., Liu, Z. G. & Boppart, S. A. Apr 18 2016 Clinical and Translational Biophotonics, Translational 2016. OSA - The Optical Society. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution ...

*  L

Labyrinth Diseases: 0.11, 0.24, 0.57, 281.83, 301.09, 392.41, 431.19, 672.53, 703.54, 821.69 ... Lewy Body Parkinson Disease: (see Parkinson Disease). Lhermitte-Duclos Disease: (see Hamartoma Syndrome, Multiple: (Cowden's ... Lysosomal Enzyme Disorders: (see Lysosomal Storage Diseases). Lysosomal Storage Diseases: 0.08, 0.41, 0.95, 2.75, 5.50, 15.65, ... Libman-Sacks Disease: (see Lupus Erythematosus, Systemic). Lice Infestations: 0.03, 0.41, 0.62, 0.93, 7.50, 13.93, 85.54, 96.50 ...

*  Neural Mechanisms Engaged in Control of Eye Movements - Full Text View -

Vestibular Diseases. Neurodegenerative Diseases. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. Nervous ... Degenerative CNS diseases, extrapyramidal disorders, Spino-cerebellar ataxias, Cerebrovascular diseases, demyelinating diseases ... Subjects with eye disease such as corneal or scleral abrasion or disease, glaucoma, refractive errors greater than 2 diopters. ... Degenerative Diseases of the Central Nervous System Ocular-motor and Vestibular Diseases ...

*  Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients - Full Text View ...

Peripheral Nervous System Diseases. Neuromuscular Diseases. Labyrinth Diseases. Ear Diseases. Otorhinolaryngologic Diseases. ... Neurodegenerative Diseases. Genetic Diseases, Inborn. Peripheral Nervous System Neoplasms. Nervous System Neoplasms. ... Nervous System Diseases. Neurofibromatoses. Neurofibroma. Vestibular Diseases. Neurofibromatosis 2. Nerve Sheath Neoplasms. ... Genetic and Rare Diseases Information Center resources: Neurofibromatosis Neurofibroma Acoustic Neuroma Schwannoma ..."Neuroma"&rank=15

*  Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria - Full...

Nervous System Diseases. Signs and Symptoms. Sensation Disorders. Vestibular Diseases. Labyrinth Diseases. Ear Diseases. ... Genetic and Rare Diseases Information Center resources: Ocular Motility Disorders Motor Neuro-ophthalmic Disorders ..."Learning Disorders"&rank=17

*  JCI - A cytokine-mediated link between innate immunity, inflammation, and cancer

Interleukin-10 in viral diseases and cancer: exiting the labyrinth? Immunol. Rev. 202:223-236. View this article via: CrossRef ... IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13:357-368. View this ... Inflammatory bowel disease. N. Engl. J. Med. 347:417-429. View this article via: PubMed Google Scholar ... NOD2 and Crohn's disease: Loss or gain of function? Immunity. 22:661-667. View this article via: PubMed Google Scholar ...

*  ARTICLES | Journal of Applied Physiology

In: The Vestibular Labyrinth in Health and Disease, edited by Goebel J and Highstein SM. New York: NY Academy Science, 2001, p ... which are located in the peripheral vestibular labyrinth of the inner ear and transduce linear acceleration (18, 19, 30, 31, 37 ... a possible biomechanical factor in the etiology of degenerative disease of the human locomotor system. Arch Orthop Trauma Surg ...

*  Lorne S Parnes

labyrinth diseases. Lorne S Parnes. Summary. Affiliation: University of Western Ontario. Country: Canada ... menieres disease*otologic surgical procedures*gait*glucocorticoids*drainage*auditory evoked potentials*endolymphatic duct* ... Bilateral Ménière's disease. Shahin Nabi. Department of Otolaryngology, University of Western Ontario, London Health Sciences ... Bilateral Ménière's disease. Shahin Nabi. Department of Otolaryngology, University of Western Ontario, London Health Sciences ...

*  Todd A Hillman

labyrinth diseases*electronystagmography*cerebellopontine angle*bone conduction*cranial nerve neoplasms*acoustic impedance ... facial nerve diseases*continuity of patient care*cerebrospinal fluid rhinorrhea*otologic surgical procedures*musculoskeletal ... Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. Todd A Hillman. Pittsburgh Ear Associates, 429 ... Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. Todd A Hillman. Pittsburgh Ear Associates, 429 ...


and The Stealth Killer: Is Oral Spirochetosis the Missing Link in the Dental and Heart Disease Labyrinth?. .. These two books ... Alzheimer's disease is increasing at an exponential rate....along with the increasing incidence of Lyme disease in the ... He also connects the disease with Lyme disease and other infections. He explains how the cells of the brain have difficulty up ... Alzheimer's disease; bacteria; Borrelia burgdorferi; dementia; infection; Lyme disease; periodontal pathogen; spirochetes; ...

*  Metabolites | An Open Access Metabolism & Metabolomics Journal from MDPI

Cancer is a complex disease and a common term used for more than 100 diseases, whereas metabolism describes a labyrinth of ... Cancer is a complex disease and a common term used for more than 100 diseases, whereas metabolism describes a labyrinth of ... Biomarker Research in Parkinson's Disease Using Metabolite Profiling. by Jesper F. Havelund, Niels H. H. Heegaard, Nils J. K. ... It is essential to understand metabolism in the context of cancer for the early detection of disease biomarkers and to find ...

*  Diseases Affecting the Inner Ear Balance Systems in Rabbits | petMD

The vestibular system is a major component of the sensory system, a complex system that includes the labyrinth of the inner ear ... In rabbits, vestibular disease is commonly due to ear infection and brain abscesses. Lop-eared rabbits may be more likely to be ... vestibular disease. Any disorder of the neurons that may be characterized by rolling, circling, falling, etc. ... FEATURED8 Breeds Prone to Dental Disease. Some dogs, particularly smaller breeds, are at a higher risk of developing ...

*  Meniere's Disease | Grand Strand Health

Learn more about Meniere's Disease at Grand Strand Medical Center DefinitionCausesRisk ... Meniere's disease is a disorder of the labyrinth in the inner ear that causes vertigo, tinnitus, and hearing problems. The ... Meniere's disease is more common in adults aged 20-60 years, and in Caucasians. Other factors that may increase your chance of ... Meniere's disease may cause fluctuating symptoms, which may come on suddenly. They typically involve only one ear, but may ...

*  Indications

Ménière's disease Ménière's disease is associated with a change in fluid volume within the labyrinth. It can cause vertigo, ... This disease is much more common in persons with poor Eustachian tube function e.g. patients with cleft lip and palate or Down ... In all ossicular diseases, the first objective is to restore the function of the ossicular chain by middle ear surgery. ...

*  Injured Ear: Anatomy

Inner ear, or labyrinth: includes the cochlea and semi-circular canals * Cochlea: contains fluid and hair cells ...

Autoimmune inner ear disease: Autoimmune inner ear disease is a suspected autoimmune disease characterized by rapidly progressive bilateral sensorineural hearing loss.Inner Ear, Autoimmune (eMedicine, 2006) It occurs when the body's immune system attacks cells in the inner ear that are mistaken for a virus or bacteria.Vestibular system: The vestibular system, in most mammals, is the sensory system that provides the leading contribution about the sense of balance and spatial orientation for the purpose of coordinating movement with balance. Together with the cochlea, a part of the auditory system, it constitutes the labyrinth of the inner ear in most mammals, situated in the vestibulum in the inner ear (Figure 1).Placenta: The placenta (also known as afterbirth) is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply, fight against internal infection and produce hormones to support pregnancy. The placenta provides oxygen and nutrients to growing babies and removes waste products from the baby's blood.Dog healthMedial vestibular nucleus: The medial vestibular nucleus is one of the vestibular nuclei. It is located in the medulla oblongata.Endolymphatic sac tumor: An endolymphatic sac tumor is a very uncommon papillary epithelial neoplasm arising within the endolymphatic sac or endolymphatic duct. This tumor shows a very high association with von Hippel-Lindau syndrome (VHL).Trophoblast: Trophoblasts (from Greek trephein: to feed, and blastos: germinator) are cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg.Lagarosiphon major: Lagarosiphon major is a monocotic aquatic plant native to Southern Africa. Common names include African elodea, curly waterweed, oxygen weed and South African oxygen weed.Endolymph: Endolymph is the fluid contained in the membranous labyrinth of the inner ear. It is also called Scarpa's fluid, after Antonio Scarpa.Vision in fishes: Vision is an important sensory system for most species of fish. Fish eyes are similar to terrestrial vertebrates like birds and mammals, but have a more spherical lens.Prenatal nutrition: Nutrition and weight management before and during :pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.LabyrinthitisVertigo (Marvel Comics): Vertigo is a native of the Savage Land who obtained superhuman powers at a young age by genetic engineering. Her powers enable her to render a person severely dizzy and even unconscious.

(1/121) 3D MRI of the membranous labyrinth. An age related comparison of MR findings in patients with labyrinthine fibrosis and in persons without inner ear symptoms.

PURPOSE: We compared MRI of the membranous labyrinth in patients with chronic non-neoplastic inner ear disease and MR signs of labyrinthine fibrosis and controls depending on their age, in order to establish whether there were any MR differences regarding patient age groups, control age groups and between the patients and controls themselves. MATERIALS AND METHODS: Clinical ENT examinations as well as a T2* weighted 3D CISS (Constructive Interference in Steady State) sequence with a slice thickness of 0.7 mm were performed. Our collective was subdivided as follows: 0-19 years (10 controls, 3 patients with chronic non-neoplastic inner ear disease), 20-49 years (55 controls, 8 patients), 50 years and older (40 controls, 22 patients). Detectability of labyrinthine structures (e.g. cochlea, vestibule, semicircular canals) and filling defects were evaluated. RESULTS: In the 3 age-groups of the control collective no significant differences were observed in the membranous labyrinth. However differences concerning labyrinthine detectability emerged between controls and patients in both the 20-49 years and 50 years and older age groups. In the patient collective the 3 age groups showed no significant discrepancy in the mean number of lesions. CONCLUSION: Filling defects of the membranous labyrinth on 3D CISS MR images are pathological even in older persons. We would therefore recommend high resolution T2* weighted MRI in the case of suspected labyrinthine fibrosis.  (+info)

(2/121) Sound- and pressure-induced vertigo associated with dehiscence of the roof of the superior semicircular canal.

In many types of peripheral vertigo, imaging is not part of the initial evaluation. We present a patient with sound- and pressure-induced vertigo associated with bony dehiscence of the roof of the superior semicircular canal. The diagnosis of this new entity can only be made by high-resolution coronal CT imaging of the temporal bones. In patients with this symptom complex, CT should be performed early in the diagnostic workup.  (+info)

(3/121) Cavernous angioma of the internal acoustic meatus--case report.

A 39-year-old female presented with an intrameatal cavernous angioma manifesting as hearing loss and tinnitus in the right ear which progressed over 8 months. Magnetic resonance (MR) images revealed an intrameatal lesion as ultra-high intensity, nearly as bright as cerebrospinal fluid, on the T2-weighted images, and isointensity on the T1-weighted images. Computed tomography (CT) showed the mass accompanied by stippled patterns of calcification. The patient underwent surgery under a diagnosis of calcified acoustic neurinoma. Histological studies were compatible with cavernous angioma. Intrameatal cavernous angioma is a rare disease which requires differential diagnosis from the more common neurinoma or meningioma in this location. Intrameatal lesion with ultra-high intensity on T2-weighted MR imaging and stippled patterns of calcification on CT is more likely to be cavernous angioma than acoustic neurinoma. These neuroimaging features are important information in deciding the treatment strategy.  (+info)

(4/121) Coriolis-force-induced trajectory and endpoint deviations in the reaching movements of labyrinthine-defective subjects.

When reaching movements are made during passive constant velocity body rotation, inertial Coriolis accelerations are generated that displace both movement paths and endpoints in their direction. These findings directly contradict equilibrium point theories of movement control. However, it has been argued that these movement errors relate to subjects sensing their body rotation through continuing vestibular activity and making corrective movements. In the present study, we evaluated the reaching movements of five labyrinthine-defective subjects (lacking both semicircular canal and otolith function) who cannot sense passive body rotation in the dark and five age-matched, normal control subjects. Each pointed 40 times in complete darkness to the location of a just extinguished visual target before, during, and after constant velocity rotation at 10 rpm in the center of a fully enclosed slow rotation room. All subjects, including the normal controls, always felt completely stationary when making their movements. During rotation, both groups initially showed large deviations of their movement paths and endpoints in the direction of the transient Coriolis forces generated by their movements. With additional per-rotation movements, both groups showed complete adaptation of movement curvature (restoration of straight-line reaches) during rotation. The labyrinthine-defective subjects, however, failed to regain fully accurate movement endpoints after 40 reaches, unlike the control subjects who did so within 11 reaches. Postrotation, both groups' movements initially had mirror image curvatures to their initial per-rotation reaches; the endpoint aftereffects were significantly different from prerotation baseline for the control subjects but not for the labyrinthine-defective subjects reflecting the smaller amount of endpoint adaptation they achieved during rotation. The labyrinthine-defective subjects' movements had significantly lower peak velocity, higher peak elevation, lower terminal velocity, and a more vertical touchdown than those of the control subjects. Thus the way their reaches terminated denied them the somatosensory contact cues necessary for full endpoint adaptation. These findings fully contradict equilibrium point theories of movement control. They emphasize the importance of contact cues in adaptive movement control and indicate that movement errors generated by Coriolis perturbations of limb movements reveal characteristics of motor planning and adaptation in both healthy and clinical populations.  (+info)

(5/121) Dumbbell schwannomas of the internal auditory canal.

BACKGROUND AND PURPOSE: Benign tumors of the internal auditory canal (IAC) may leave the confines of the IAC fundus and extend into inner ear structures, forming a dumbbell-shaped lesion. It is important to differentiate dumbbell lesions, which include facial and vestibulocochlear schwannomas, from simple intracanalicular schwannomas, as surgical techniques and prognostic implications are affected. In this article, the imaging and clinical features of these dumbbell schwannomas are described. METHODS: A dumbbell lesion of the IAC is defined as a mass with two bulbous segments, one in the IAC fundus and the other in the membranous labyrinth of the inner ear or the geniculate ganglion of the facial nerve canal, spanned by an isthmus. Twenty-four patients with dumbbell lesions of the IAC had their clinical and imaging data retrospectively reviewed. Images were evaluated for contour of the mass and extension into the membranous labyrinth or geniculate ganglion. RESULTS: Ten of 24 lesions were facial nerve dumbbell lesions. Characteristic features included an enhancing "tail" along the labyrinthine segment of the facial nerve and enlargement of the facial nerve canal. Dumbbell schwannomas of the vestibulocochlear nerve (14/24) included transmodiolar (8/14), which extended into the cochlea, transmacular (2/14), which extended into the vestibule, and combined transmodiolar/transmacular (4/14) types. CONCLUSION: Simple intracanalicular schwannomas can be differentiated from transmodiolar, transmacular, and facial nerve schwannomas with postcontrast and high-resolution fast spin-echo T2-weighted MR imaging. Temporal bone CT is reserved for presurgical planning in the dumbbell facial nerve schwannoma group.  (+info)

(6/121) Enhancement of the eighth cranial nerve and labyrinth on MR imaging in sudden sensorineural hearing loss associated with human herpesvirus 1 infection: case report.

The case of a 61-year-old woman who presented with herpes labialis, subclinical meningitis, and sudden onset of bilateral sensorineural hearing loss is presented. Contrast-enhanced MR imaging showed marked bilateral enhancement of the intracanalicular portion of the eighth cranial nerve, right cochlea, and left vestibule. Polymerase chain reaction was positive for human herpesvirus 1 obtained from the cerebral spinal fluid, which suggested the diagnosis of viral neuritis.  (+info)

(7/121) Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis.

OBJECTIVES: To clarify the clinical significance of positional down beat nystagmus (pDBN). METHODS: A discussion of the neuro-otological findings in 50 consecutive patients with pDBN. RESULTS: In 38 patients there was evidence of CNS disease (central group) but in 12 there was not (idiopathic group). In the CNS group, presenting symptoms were gait, speech, and autonomic dysfunction whereas in the idiopathic group patients mostly reported positional vertigo. The main neurological and oculomotor signs in the CNS group were explained by cerebellar dysfunction, including 13 patients with multiple system atrophy. In patients with multiple system atrophy with a prominent extrapyramidal component, the presence of pDBN was helpful in the differential diagnosis of atypical parkinsonism. No patient with pDBN had the Arnold-Chiari malformation, a common cause of constant down beat nystagmus (DBN). In the idiopathic group, the pDBN had characteristics which suggested a peripheral labyrinthine disorder: vertigo, adaptation, and habituation. In six patients an additional torsional component was found (concurrently with the pDBN in three). Features unusual for peripheral disorder were: bilateral positive Dix-Hallpike manoeuvre in nine of 12 patients and selective provocation by the straight head-hanging manoeuvre in two. CONCLUSION: It is argued that some patients with idiopathic pDBN have benign paroxysmal positional vertigo (BPPV) with lithiasis of the anterior canal. The torsional component may be weak, because of the predominantly sagittal orientation of the anterior canal, and may not be readily seen clinically. Nystagmus provocation by bilateral Dix-Hallpike and straight head-hanging may be explained by the vertical upwards orientation of the ampullary segment of the anterior canal in the normal upright head position. Such orientation makes right-left specificity with the Dix-Hallpike manoeuvre less important than for posterior canal BPPV. This orientation requires a further downwards movement of the head, often achieved with the straight head-hanging position, to provoke migration of the canaliths. The straight head-hanging manoeuvre should be carried out in all patients with a history of positional vertigo and a negative Dix-Hallpike manoeuvre.  (+info)

(8/121) Vestibular information is required for dead reckoning in the rat.

Dead reckoning is an on-line form of spatial navigation used by an animal to identify its present location and return directly to a starting location, even after circuitous outward trips. At present, it is not known which of several self-movement cues (efferent copy from movement commands, proprioceptive information, sensory flow, or vestibular information) are used to compute homeward trajectories. To determine whether vestibular information is important for dead reckoning, the impact of chemical labyrinthectomy was evaluated in a test that demanded on-line computation of a homeward trajectory. Rats were habituated to leave a refuge that was visible from all locations on a circular table to forage for large food pellets, which they carried back to the refuge to eat. Two different probe trials were given: (1) the rats foraged from the same spatial location from a hidden refuge in the light and so were able to use visual cues to navigate; (2) the same procedure took place in the dark, constraining the animals to dead reckon. Although control rats carried food directly and rapidly back to the refuge on both probes, the rats with vestibular lesions were able to do so on the hidden refuge but not on the dark probe. The scores of vestibular reflex tests predicted the dead reckoning deficit. The vestibular animals were also impaired in learning a new piloting task. This is the first unambiguous demonstration that vestibular information is used in dead reckoning and also contributes to piloting.  (+info)

autoimmune inner e

  • The investigators plan to conduct an open-label intratympanic injection proof-of-concept trial of golimumab, a TNF-alpha inhibitor, assessing for hearing loss progression in patients with autoimmune inner ear disease (AIED). (
  • On the other hand, steroids are drug of choice for autoimmune inner ear disease and commonly used for sudden hearing loss. (


  • Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. (
  • In this study the primary objective is to assess efficacy of Acyclovir in control of symptoms in patients with Meniere's disease specially their vertigo attacks. (
  • Inclusion criteria would be patient's willingness to participate in the study and follow ups, being 18 years old or older, having at least 2 vertigos per month each at least 20 min, interfering with function, and not on medication for Meniere's disease for at least 3 months before the trial. (
  • This trial aims to compare transtympanic steroids against the standard treatment (transtympanic gentamicin) in refractory unilateral Meniere's disease. (
  • Meniere's disease is characterised by episodic spontaneous vertigo attacks with hearing loss, ringing sounds and fullness in the ear. (


  • 1) To review a 10-year experience of endolymphatic sac surgery (ESS) and intratympanic gentamicin (ITG) for intractable Ménière's disease (MD), and 2) to compare preoperative and postoperative outcomes. (


  • Criteria for excluding subjects will include eye disease such as corneal or scleral abrasion or disease, glaucoma, refractive errors greater than 2 diopters and concurrent medication with CNS-active agents. (


  • Criteria for inclusion/exclusion: The investigators will study patients with neurological disorders causing abnormal eye movements: Degenerative CNS diseases, extrapyramidal disorders, Spino-cerebellar ataxias, Cerebrovascular diseases, demyelinating diseases, Ocular motor and vestibular palsies, Mitochondrial and other ocular myopathies. (

hearing loss

  • The disease is characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure. (