Ketoprofen
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Hypodermoclysis
Phenylpropionates
Diclofenac
Nefopam
Skin Irritancy Tests
I.v. intraoperative ketoprofen in small children during adenoidectomy: a dose-finding study. (1/242)
We have investigated if a low dose of ketoprofen (0.3 mg kg-1) i.v., provided as good analgesia with less adverse effects than higher doses (1.0 and 3.0 mg kg-1) in 220 children, aged 1-7 yr, undergoing adenoidectomy, in a prospective, randomized, double-blind, placebo-controlled, parallel group study. The postoperative analgesic effect was notable even after the lowest dose of ketoprofen. However, the higher doses seemed to provide better analgesia with no increase in adverse events or intraoperative bleeding. None of the children experienced postoperative bleeding which would have required intervention or delayed discharge from hospital. This study confirms the efficacy and safety of intraoperative ketoprofen in children during adenoidectomy. (+info)Ketoprofen, diclofenac or ketorolac for pain after tonsillectomy in adults? (2/242)
We have compared the analgesic and opioid sparing effect of three i.v. non-steroidal anti-inflammatory drugs with placebo in a randomized, double-blind, placebo-controlled study in 80 adult patients after elective tonsillectomy. A standard anaesthetic was used. After induction of anaesthesia, patients received ketoprofen 100 mg, diclofenac 75 mg or ketorolac 30 mg by i.v. infusion over 30 min. Patients in the placebo group received saline. Ketoprofen and diclofenac infusions were repeated after 12 h and ketorolac infusion at 6 h and 12 h. Oxycodone was used as rescue analgesic. Patients in the ketoprofen group requested 32% less opioid and patients in the diclofenac and ketorolac groups 42% less opioid than those in the placebo group (P < 0.05). There were one, two and six patients in the placebo, diclofenac and ketorolac groups, respectively, but none in the ketoprofen group, who did not request opioid analgesia during the study (P < 0.05, ketorolac vs placebo and ketoprofen). Visual analogue pain scores were similar in all groups. Visual analogue satisfaction scores were significantly higher in the diclofenac group compared with the placebo group. The incidence of nausea was 44-54%. There were no differences in the incidence of other adverse reactions. We conclude that all three non-steroidal anti-inflammatory drugs were superior to placebo after tonsillectomy. (+info)Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide. (3/242)
Acylglucuronides formed from carboxylic acids by UDP-glucuronosyltransferases (UGTs) are electrophilic metabolites able to covalently bind proteins. In this study, we demonstrate the reactivity of the acylglucuronide from the nonsteroidal anti-inflammatory drug, ketoprofen, toward human and rat liver UGTs. Ketoprofen acylglucuronide irreversibly inhibited the glucuronidation of 1-naphthol and 2-naphthol catalyzed by human liver microsomes or by the recombinant rat liver isoform, UGT2B1, which is the main isoform involved in the glucuronidation of the drug. A decrease of about 35% in the glucuronidation of 2-naphthol was observed when ketoprofen acylglucuronide was produced in situ in cultured V79 cells expressing UGT2B1. Inhibition was always associated with the formation of microsomal protein-ketoprofen adducts. The presence of these covalent adducts within the endoplasmic reticulum of cells expressing UGT2B1 was demonstrated following addition of ketoprofen to culture medium by immunofluorescence microscopy with antiketoprofen antibodies. Immunoblots of liver microsomes incubated with ketoprofen acylglucuronide and probed with antiketoprofen antibodies revealed the presence of several protein adducts; among those was a major immunoreactive protein at 56 kDa, in the range of the apparent molecular mass of UGTs. The adduct formation partially prevented the photoincorporation of the UDP-glucuronic acid (UDP-GlcUA) analog, [beta-32P]5N3UDP-GlcUA, on the UGTs, suggesting that ketoprofen glucuronide covalently reacted with the UDP-GlcUA binding domain. Finally, UGT purification from rat liver microsomes incubated with ketoprofen glucuronide led to the isolation of UGT adducts recognized by both anti-UGT and antiketoprofen antibodies, providing strong evidence that UGTs are targets of this metabolite. (+info)Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy. (4/242)
OBJECTIVE: The primary objective of this study was to assess the kinetics of ketoprofen in synovial fluid and intra-articular tissues in relation to plasma. The secondary objective was to study whether intra-articular tissues act as reservoirs. METHODS: The ketoprofen concentration was analysed in plasma, synovial fluid and intra-articular tissues after single application of a 30 mg plaster (n = 40), multiple applications for 5 days (n = 30) or oral intake of 50 mg (n = 30) in patients undergoing knee arthroscopy. RESULTS: Median CMax values after topical application were 12.8 ng/ml in synovial fluid, 56.7 ng/g in synovial tissue, 349.3 ng/g in meniscus and 568.9 ng/g in cartilage. CONCLUSION: Topical applications of ketoprofen allow the attainment of high intra-articular tissue concentrations. (+info)Interferon alfa-2b alone or in combination with ketoprofen as treatment for interferon-naive chronic hepatitis C patients. (5/242)
BACKGROUND: Non-steroidal anti-inflammatory drugs may amplify the anti-viral effect of alpha-interferon in vitro but in vivo data are still controversial. AIM: : To test the hypothesis that ketoprofen may increase the rate of response to alpha-interferon of chronic hepatitis C patients. METHODS: Fifty patients with chronic hepatitis C who had never received alpha-interferon were randomly assigned to receive 3-8 MU of alpha2b-interferon, three times weekly for 6 months, alone or in association with ketoprofen at a dose of 200 mg/day five times weekly. The virological response to treatment (undetectable HCV RNA in serum) was evaluated after 3 months and at the end of treatment, and 6 and 12 months after therapy withdrawal. RESULTS: One patient under combination therapy stopped the ketoprofen for persisting epigastric pain. Complete response under treatment was observed in 15 out of 24 (62.5%) patients receiving alpha2b-interferon alone and in 14 out of 26 (53.8%) patients under combination therapy (P=N.S.). One year after the end of treatment, a sustained response was seen in 4 out of 24 (16.2%) patients treated with alpha2b-interferon and in 5 out of 26 (19.2%) patients having received the combination (P=N.S.). CONCLUSION: Administration of ketoprofen does not increase either the primary or the sustained response to alpha2b-interferon therapy of interferon-naive chronic hepatitis C patients. (+info)Helix 6 of subdomain III A of human serum albumin is the region primarily photolabeled by ketoprofen, an arylpropionic acid NSAID containing a benzophenone moiety. (6/242)
It is well known that the subdomain III A (site II) of human serum albumin (HSA) binds a variety of endogenous and exogenous substances. However, the nature of the microenvironment of the binding site remains unclear. Ketoprofen (KP), an arylpropionic acid NSAID which contains a benzophenone moiety, was used as a photoaffinity labeling agent to label the binding region. Subsequent CNBr cleavage of the photolabeled HSA revealed that the 11.6 kDa and 9.4 kDa fragments contained most of the incorporated radioactivity. Competition experiments showed that the 11.6 kDa fragment contains the common binding region for site II ligands. This fragment was redigested with Achromobacter lyticus protease I (AP-I) and the amino acid sequence of the photolabeled peptide was determined to be XCTESLVNRR, which corresponds to the sequence 476C-485K of HSA. The complete amino acid sequence of the corresponding AP-I digested HSA peptide encompasses residues 476 to 499, which form helices 5 and 6 of subdomain III A. The HSA-Myr X-ray crystallography data showed that helix 5 is involved to the least extent in ligand binding. A docking model provided further support that helix 6 represents the photolabeled region of KP. (+info)Postoperative pain after adenoidectomy in children. (7/242)
We have investigated if pain intensity or analgesic requirements in hospital predicted pain intensity, pain duration or analgesic requirements at home in 611 children, aged 1-7 yr, after day-case adenoidectomy. We also investigated if ketoprofen 0.3-3.0 mg kg-1, administered pre-emptively i.v. during operation, modified pain at home. In hospital, a prospective, randomized, double-blind, placebo-controlled study design was performed. A standard anaesthetic technique was used in all children and fentanyl i.v. was available for rescue analgesia. After discharge, the study design was open, experimental, prospective and longitudinal. On return home, children were prescribed ketoprofen tablets 5 mg kg-1 day-1. Parents were asked to complete an analgesia diary; non-responders were contacted by telephone. The response rate was 91%. The number of doses of fentanyl given in hospital correlated with pain intensity at home (P < 0.001). There were no other correlations and no pre-emptive effect of ketoprofen. (+info)Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a 'futile cycle' of elimination. (8/242)
AIMS: To assess if futile cycling of ketoprofen occurs in patients with decreased renal function. METHODS: Ketoprofen was administered to six haemodialysis-dependent patients with end-stage renal disease as single (50 mg) or multiple doses (50 mg three times daily, for 7 days). Plasma and dialysate concentrations of the unconjugated and glucuronidated R- and S-enantiomers of ketoprofen were determined using h.p.l.c. following the single and multiple dosing. RESULTS: The oral clearance was decreased and terminal elimination half-lives of R- and S-ketoprofen and the corresponding acyl glucuronides were increased in functionally anephric patients compared with healthy subjects. In contrast with the R-isomers, S-ketoprofen and S-ketoprofen glucuronide exhibited an unexpected accumulation (2.7-3. 8 fold) after repeated dosing achieving S:R ratios of 3.3+/-1.7 and 11.2+/-5.3, respectively. The plasma dialysis clearances for R- and S-ketoprofen glucuronides were 49.4+/-19.8 and 39.0+/-15.9 ml min-1, respectively, and 10.8+/-17.6 and 13.3+/-23.5 ml min-1 for unconjugated R- and S-ketoprofen. CONCLUSIONS: The selective accumulation of S-ketoprofen and its acyl glucuronide are consistent with amplification of chiral inversion subsequent to futile cycling between R-ketoprofen and R-ketoprofen glucuronide. Severe renal insufficiency, and possibly more modest decrements, results in a disproportionate increase in systemic exposure to the S-enantiomer which inhibits both pathologic and homeostatic prostaglandin synthesis. (+info)Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation, which works by inhibiting the production of prostaglandins.
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, fever, and inflammation in the body. It works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body.
Ketoprofen has analgesic, anti-inflammatory, and antipyretic properties, making it a useful medication for managing various conditions such as arthritis, menstrual cramps, muscle pain, dental pain, and migraines. It is available in various forms, including oral capsules, tablets, suppositories, and topical creams or gels.
Like other NSAIDs, ketoprofen can cause side effects such as stomach ulcers, bleeding, and kidney damage if used in high doses or for extended periods. It is essential to follow the recommended dosage and consult with a healthcare provider before using this medication.
Non-steroidal anti-inflammatory agents (NSAIDs) are a class of drugs that work by inhibiting the activity of cyclooxygenase enzymes, thereby reducing inflammation, pain, and fever, without possessing hormonal properties like steroids.
Non-steroidal anti-inflammatory agents (NSAIDs) are a class of medications that reduce pain, inflammation, and fever. They work by inhibiting the activity of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, chemicals that contribute to inflammation and cause blood vessels to dilate and become more permeable, leading to symptoms such as pain, redness, warmth, and swelling.
NSAIDs are commonly used to treat a variety of conditions, including arthritis, muscle strains and sprains, menstrual cramps, headaches, and fever. Some examples of NSAIDs include aspirin, ibuprofen, naproxen, and celecoxib.
While NSAIDs are generally safe and effective when used as directed, they can have side effects, particularly when taken in large doses or for long periods of time. Common side effects include stomach ulcers, gastrointestinal bleeding, and increased risk of heart attack and stroke. It is important to follow the recommended dosage and consult with a healthcare provider if you have any concerns about using NSAIDs.
Hypodermoclysis is the subcutaneous administration of fluids, generally done through a small-gauge needle or butterfly catheter, which is inserted just under the skin to provide hydration, typically for patients who are unable to take fluids orally and for whom intravenous access is difficult or not preferred.
Hypodermoclysis is a medical term that refers to the subcutaneous administration of fluids using a small needle or catheter. This procedure involves injecting fluid into the tissue just under the skin, typically in the lower abdomen or thigh region. The fluid then gradually gets absorbed into the bloodstream over several hours.
Hypodermoclysis is an alternative method for hydration when intravenous (IV) access is difficult or not possible. It can be used to provide fluids, medications, and electrolytes in patients who have poor venous access, are at risk of fluid overload, or cannot tolerate oral hydration.
It's important to note that hypodermoclysis should only be performed by trained medical professionals, as there are potential risks associated with the procedure, such as infection, fluid infiltration, and tissue damage.
Phenylpropionates are a class of organic compounds, including certain drugs such as ephedrine and pseudoephedrine, which contain a phenylethanoic acid structure with a propionate substitution.
Phenylpropionates are a group of organic compounds that contain a phenyl group and a propionate group. In the context of pharmaceuticals, phenylpropionates often refer to a specific type of esterified hormone, such as testosterone phenylpropionate or nandrolone phenylpropionate. These esters are used in some forms of anabolic-androgenic steroids and are created by attaching a phenylpropionate group to the parent hormone molecule. This modification allows for a slower release and longer duration of action when administered intramuscularly.
It is important to note that these substances have medical uses, but they also carry risks and potential side effects, especially when used inappropriately or without medical supervision. They are controlled substances in many countries due to their potential for misuse and abuse.
Postoperative pain is defined as tissue injury-related discomfort that occurs following a surgical procedure, which may be experienced at the incision site or in remote areas, and can vary in intensity and duration based on the type and extent of surgery, individual pain thresholds, and presence of any preexisting chronic pain conditions.
Postoperative pain is defined as the pain or discomfort experienced by patients following a surgical procedure. It can vary in intensity and duration depending on the type of surgery performed, individual pain tolerance, and other factors. The pain may be caused by tissue trauma, inflammation, or nerve damage resulting from the surgical intervention. Proper assessment and management of postoperative pain is essential to promote recovery, prevent complications, and improve patient satisfaction.
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation in conditions such as arthritis, menstrual cramps, and migraines, working by inhibiting the production of prostaglandins.
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever. It works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. Diclofenac is available in various forms, including tablets, capsules, suppositories, topical creams, gels, and patches.
The medical definition of Diclofenac is:
Diclofenac sodium: A sodium salt of diclofenac, a phenylacetic acid derivative that is a potent inhibitor of prostaglandin synthesis. It is used in the treatment of inflammation and pain in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other conditions. Diclofenac sodium has also been used to treat actinic keratosis, a precancerous skin condition. It is available by prescription in various forms, including oral tablets, capsules, topical creams, gels, and patches.
Nefopam is a non-narcotic, centrally acting analgesic with potential serotonergic and noradrenergic properties, used primarily for the treatment of moderate to severe postoperative pain, although its use may be extended to other types of acute or chronic pain depending on the clinical context.
Nefopam is a non-narcotic, centrally acting analgesic used to treat moderate to severe pain. It is a non-opioid agent that works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the central nervous system, thereby enhancing their pain inhibitory effects. Nefopam may also have some anti-inflammatory activity. It is available as an oral preparation and is often used in combination with other analgesics for more effective pain relief. Side effects of nefopam include nausea, dizziness, dry mouth, and sweating.
Adenoidectomy is a surgical procedure that involves the removal of the adenoids, typically conducted to alleviate recurrent respiratory infections, sleep-disordered breathing, or hearing problems.
Adenoidectomy is a surgical procedure in which the adenoids are removed. The adenoids are a patch of tissue located behind the nasal cavity, near the roof of the mouth. They help to filter out germs that are breathed in through the nose. However, sometimes the adenoids can become enlarged or infected, leading to problems such as difficulty breathing through the nose, recurrent ear infections, and sleep apnea. In these cases, an adenoidectomy may be recommended to remove the adenoids and alleviate these symptoms.
The procedure is typically performed on an outpatient basis, which means that the patient can go home the same day as the surgery. The surgeon will use a special instrument to remove the adenoids through the mouth, without making any external incisions. After the surgery, the patient may experience some discomfort, sore throat, and difficulty swallowing for a few days. However, these symptoms usually resolve within a week or two.
It is important to note that an adenoidectomy is not the same as a tonsillectomy, which is the surgical removal of the tonsils. While the tonsils and adenoids are both part of the immune system and located in the same area of the mouth, they serve different functions and may be removed separately or together depending on the individual's medical needs.
Phonophoresis is a therapeutic procedure where ultrasound is used to facilitate the delivery of topical medications into the tissues, enhancing their penetration and potential therapeutic effects.
Phonophoresis is a physical therapy modality that combines the use of ultrasound and topical medications to enhance the delivery of the medication into the affected tissues. This technique uses ultrasonic waves to help drive the medication through the skin and into the underlying tissues, potentially increasing the effectiveness of the treatment. It is often used to treat localized inflammation, pain, and muscle spasms in conditions such as tendonitis, bursitis, and arthritis. The ultrasound gel typically contains the medication, which is applied to the skin during the treatment session.
"Skin irritancy tests are scientific procedures that involve applying potential irritants to the skin of human or animal subjects to evaluate and compare their irritation potential, typically for the purpose of assessing product safety in cosmetics, pharmaceuticals, or chemical industries."
Skin irritancy tests are experimental procedures used to determine the potential of a substance to cause irritation or damage to the skin. These tests typically involve applying the substance to intact or abraded (damaged) skin of human volunteers or animals, and then observing and measuring any adverse reactions that occur over a specified period. The results of these tests can help assess the safety of a substance for use in consumer products, pharmaceuticals, or industrial applications. It is important to note that the ethical considerations and regulations surrounding animal testing have led to an increased focus on developing alternative methods, such as in vitro (test tube) tests using reconstructed human skin models.
Piroxicam is a non-selective non-steroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever by inhibiting the activity of cyclooxygenase-1 and cyclooxygenase-2 enzymes.
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat pain, inflammation, and fever. It works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, chemicals that contribute to inflammation and pain.
Piroxicam is available as a prescription medication and is used to treat conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is typically taken orally in the form of tablets or capsules, and its effects can last for up to 12 hours.
Like other NSAIDs, piroxicam can cause side effects such as stomach ulcers, bleeding, and kidney problems, especially when used at high doses or for long periods of time. It is important to use piroxicam only as directed by a healthcare provider and to follow any recommended precautions.
Ketoprofen
... topical patches are being used for treatment of musculoskeletal pain. Ketoprofen can also be used for treatment of ... Ketoprofen has one stereogenic center in the side chain and hence exists as mirror-image twins. Majority of the profens are ... Ketoprofen is a common NSAID, antipyretic, and analgesic used in horses and other equines. It is most commonly used for ... Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic ...
CYP2C9
"ketoprofen , C16H14O3". PubChem. Abdullah Alkattan & Eman Alsalameen (2021) Polymorphisms of genes related to phase-I metabolic ...
Analgesic
Coaccioli S (August 2011). "Ketoprofen 2.5% gel: a clinical overview". European Review for Medical and Pharmacological Sciences ... October 2012). "Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen". Journal of Pharmaceutical ... Kokki H (October 2010). "Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients". Paediatric Drugs. 12 ( ... "Pain and ketoprofen: what is its role in clinical practice?". Reumatismo. 62 (3): 172-88. doi:10.4081/reumatismo.2010.172. PMID ...
Dexketoprofen
... is the (S)-enantiomer of ketoprofen. Technically it is a chiral switch of (±)-ketoprofen. The switch was done for ... It is the dextrorotatory stereoisomer of ketoprofen. ...
Dendrimer
Cheng, Y.; Xu, T; Fu, R (2005). "Polyamidoamine dendrimers used as solubility enhancers of ketoprofen". European Journal of ...
Glucametacin
Ibba G, Uras R, Perpignano G (1983). "Double-blind comparison of glucametacin and ketoprofen in chronic arthropathies". Current ...
Piketoprofen
Chemically, it is the 4-picolineamide of the NSAID ketoprofen. Fabregas JL, Cucala J, Segura J, Tarrus E (May 1986). " ...
Grimace scale
Kawano, T., Takahashi, T., Iwata, H., Morikawa, A., Imori, S., Waki, S., ... & Yokoyama, M. (2014). "Effects of ketoprofen for ... but carprofen and ketoprofen are efficacious only at doses much higher than currently recommended: acetaminophen is not ...
Equine exertional rhabdomyolysis
... or Ketoprofen. This will help to bring the inflammation down while also acting as a pain reliever. NSAID's should not be used ...
Chiral analysis
The NSAID drugs ketoprofen and ibuprofen has been separated using ristocetin CSP. Crown ethers, like cyclodextrin-type CSPs ...
Laminitis
... and ketoprofen in horses". Journal of the American Veterinary Medical Association. 202 (1): 71-7. PMID 8420909. Sabaté D, ...
Hisamitsu Pharmaceutical
Its product lines include the Salonpas pain relief patches; Mohrus Tape, a transdermal patch containing ketoprofen for the ...
Treatment of equine lameness
1993) Effects of large doses of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J. Am. Vet. Med. Ass. 202, 71-77 ...
Indian vulture
There were other compounds like aceclofenac and ketoprofen which were in use and were harmful. In 2008, Government of India ...
Chiral inversion
Ibuprofen Dexibuprofen Ketoprofen Thalidomide Fenoprofen Chiral drugs Chiral switch Aboul-Enein HY, Wainer IW (1997). The ... ketoprofen, fenoprofen, benoxaprophen, etc. For this group, only S-enantiomer (eutomer) is active i.e. has analgesic and anti- ... studies using benoxaprofen and ketoprofen show that one of the primary sites of inversion in rats is the GI tract. Chiral ...
Sanofi
Telfast for Seasonal Allergy Relief Enterogermina Medicine for Diarrhea - Pain Bi-profined (Ketoprofen), for pain. Solpadol ( ...
Antipyretic
COX inhibitors that are relatively selective for the COX-1 enzyme, such as ketoprofen and flurbiprofen. Conversely, COX ...
Fenoprofen
Ibuprofen Ketoprofen Thalidomide Chirality Chiral drugs Chiral inversion Traa MX, Derry S, Moore RA (February 2011). "Single ...
Polystyrene (drug delivery)
... utilized polystyrene solid foams as a drug delivery method to evaluate the drug release profile of ketoprofen. Researchers have ...
Otenaproxesul
June 2018). "Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced ...
Sonophoresis
... such as ibuprofen and ketoprofen. This is incredible as NSAIDs commonly cause gastrointestinal side effects such as nausea and ...
Carprofen
... ketoprofen, and meloxicam in dogs". American Journal of Veterinary Research. 68 (3): 258-264. doi:10.2460/ajvr.68.3.258. PMID ...
Benoxaprofen
This also happens to ketoprofen and naproxen, other NSAIDs, which are even more active in this respect than benoxaprofen. ...
Indian vulture crisis
... there was a higher proportion of sales of ketoprofen compared to meloxicam in 2018, despite the partial ban on ketoprofen by ... Some other drugs developed as alternatives to diclofenac - aceclofenac, ketoprofen and nimesulide - have also been shown to be ...
Ibuprofen
... , like other 2-arylpropionate derivatives such as ketoprofen, flurbiprofen and naproxen, contains a stereocenter in ...
Patient diary
Self-medication of a single headache episode with ketoprofen, ibuprofen or placebo, home-monitored with an electronic patient ...
Probenecid
Some of the important clinical interactions of probenecid include those with captopril, indomethacin, ketoprofen, ketorolac, ...
UGT2B7
... ketoprofen), and anticarcinogens (all-trans retinoic acid). UGT2B7 is the major enzyme isoform responsible for the metabolism ...
Nonsteroidal anti-inflammatory drug
Indomethacin, ketoprofen, and piroxicam use appear to lead to the highest rate of gastric adverse effects, while ibuprofen ( ... Ibuprofen and ketoprofen are now available in single-enantiomer preparations (dexibuprofen and dexketoprofen), which purport to ... Ibuprofen Dexibuprofen Naproxen Fenoprofen Ketoprofen Dexketoprofen Flurbiprofen Oxaprozin Loxoprofen Pelubiprofen Zaltoprofen ...
Pain management
The alternatively prescribed NSAIDs such as ketoprofen and piroxicam have limited benefit in chronic pain disorders and with ...
Ketoprofen - Wikipedia
Ketoprofen topical patches are being used for treatment of musculoskeletal pain. Ketoprofen can also be used for treatment of ... Ketoprofen has one stereogenic center in the side chain and hence exists as mirror-image twins. Majority of the profens are ... Ketoprofen is a common NSAID, antipyretic, and analgesic used in horses and other equines. It is most commonly used for ... Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic ...
Ketoprofen: MedlinePlus Drug Information
Ketoprofen: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking ketoprofen,. *tell your doctor and pharmacist if you are allergic to ketoprofen, aspirin or other NSAIDs such as ... Ketoprofen may be taken with food or milk to prevent upset stomach. Your doctor may also recommend that you take ketoprofen ... Take ketoprofen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or ...
Ketoprofen
These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) ...
DailyMed - KETOPROFEN capsule
Ketoprofen did not show mutagenic potential in the Ames Test. Ketoprofen administered to male rats (up to 9 mg/kg/day; or 54 mg ... The effects of ketoprofen on labor and delivery in pregnant women are unknown. Studies in rats have shown ketoprofen at doses ... Data on secretion in human milk after ingestion of ketoprofen do not exist. In rats, ketoprofen at doses of 9 mg/kg (54 mg/m 2/ ... Ketoprofen capsules USP are indicated for the management of pain. Ketoprofen capsules USP are also indicated for treatment of ...
Dexketoprofen Trometamol vs Ketoprofen in the Management of Pain
ketoprofen (n = 116). dexketoprofentrometamol (n = 123). ketoprofen (n = 124). PIDmax (%)a 73.8 (24.5). 77.7 (24.0). 72.9 (27.4 ... ketoprofen (n = 116). dexketoprofentrometamol (n = 123). ketoprofen (n = 124). Mean ± SE. 279.5 ± 17.2. 308.8 ± 17.0. 280.4 ± ... ketoprofen (n = 116). dexketoprofentrometamol (n = 123). ketoprofen (n = 124). Mean ± SE. 279.5 ± 17.2. 308.8 ± 17.0. 280.4 ± ... Cite this: Comparison of the Efficacy and Safety of Intravenously Administered Dexketoprofen Trometamol and Ketoprofen in the ...
MedlinePlus - Search Results for: KETOPROFEN
Ketoprofen overdose Ketoprofen is a nonsteroidal anti-inflammatory drug. It is used to treat pain, swelling, and inflammation. ... Ketoprofen Prescription ketoprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis ( ... available over the counter are: aspirin, acetaminophen, ibuprofen, Ketoprofen and naproxen sodium. ... arthritis caused by a breakdown ... swelling of the lining of the joints). Prescription ketoprofen capsules are also used to ...
Ketoprofen - PubMed
Although ketoprofen has low levels in breastmilk, one center reported that they had received reports of adverse renal and ... gastrointestinal side effects in breastfed infants whose mothers were taking ketoprofen. Other agents are preferred, especially ... Ketoprofen No authors listed In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child ... Although ketoprofen has low levels in breastmilk, one center reported that they had received reports of adverse renal and ...
Acute hepatitis due to ketoprofen - PubMed
Acute hepatitis due to ketoprofen J M Nores et al. Clin Rheumatol. 1991 Jun. ... Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults. Gaskell H, Derry S, Wiffen PJ, Moore RA. ... Ketoprofen-induced acute hepatitis]. Bonaventure C, Nancey S, Pont E, Michalet V, Chevalier M, Vial T, Taieb S, Claudel S, ... Jaundice related to the ingestion of ketoprofen]. Rambaud S, Nores JM, Rémy JM. Rambaud S, et al. Ann Med Interne (Paris). 1990 ...
FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 (SLC22A7) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY...
The Uptake of Ketoprofen by rOat2-LLC. The time profiles of the uptake of ketoprofen in vector- and rOat2-LLC are shown in Fig ... The uptake of ketoprofen by rOat2-LLC. a, the uptake of ketoprofen (1.3 nM) by rOat2-LLC (closed circles) and vector-LLC (open ... Inhibition of Ketoprofen Uptake by NSAIDs, Probenecid, and Glibenclamide. The uptake of [3H]ketoprofen (1.4 nM) by rOat2-LLC ... 1). Comparison of Km values determined using racemate and (S)ketoprofen suggests that the Km value of ketoprofen shows ...
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IbuprofenNSAIDs100mgFlurbiprofenFenoprofenEffects of ketoprofenInflammationDiclofenacAnalgesic and antipyreticOsteoarthritisAntipyreticNonsteroidalTopicalSynthesisOrudisDerivativesDoseImpurityNSAIDStrainsSystemicDosesTOXICITYEfficacyDosageAnti-inflaPlaceboEnzymesRheumatoid arthritisChronicPrescriptionPainMethotrexateDrugsConcentrationDrugConsultExposureCapsulesSignificantlyMetabolic
Ibuprofen12
- A 2013 systematic review indicated "The efficacy of orally administered ketoprofen in relieving moderate-severe pain and improving functional status and general condition was significantly better than that of ibuprofen and/or diclofenac. (wikipedia.org)
- A 2017 Cochrane systematic review investigating ketoprofen as a single-dose by mouth in acute, moderate-to-severe postoperative pain concluded that its efficacy is equivalent to drugs such as ibuprofen and diclofenac. (wikipedia.org)
- Ketoprofen is a non-steroidal anti-inflammatory agent of the propionic acid class that includes ibuprofen, naproxen, and fenoprofen. (nih.gov)
- Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, celecoxib and paracetamol from a Swedish perspective (Report Goodpoint 2019). (janusinfo.se)
- The risk factors for ketoprofen, naproxen, ibuprofen, celecoxib, etoricoxib and paracetamol are not considered so great that an exchange with another substance is recommended. (janusinfo.se)
- I took Ibuprofen(less than 2400mg/day), but the pain got much worse and I took 2 pills of Ketoprofen(25mg each) for 2 days. (infantrisk.com)
- i am now back to Ibuprofen(2400mg/day) just to avoid Ketoprofen, even though the pain is very bad. (infantrisk.com)
- SilviaCostinescu, Ketoprofen only transfers 0.3% of moms dose and Ibuprofen only transfers 0.1-0.7% of moms dose. (infantrisk.com)
- Fenoprofen (fen" oh proe' fen) belongs to the propionic derivative class of NSAIDs similar to naproxen, ketoprofen, flurbiprofen and ibuprofen. (nih.gov)
- Patients with fenoprofen induced liver injury should avoid other propionic acid derivatives such as flurbiprofen, ibuprofen, ketoprofen and naproxen. (nih.gov)
- Analgesic Efficacy of Ketoprofen Transdermal Patch versus Ibuprofen Oral Tablet on Postendodontic Pain in Patients with Irreversible Pulpitis: A Randomized Clinical Trial. (bvsalud.org)
- Several other nonopioid analgesics (such as ibuprofen , ketoprofen , and naproxen ) are available OTC, but higher doses may require a prescription. (msdmanuals.com)
NSAIDs2
- Since many NSAIDs possess the potential to produce gastrointestinal ulcerations and/or gastrointestinal perforation, concomitant use of ketoprofen with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided or closely monitored. (nih.gov)
- Ketoprofen belongs to the group of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). (pocketpills.com)
100mg1
- Untuk Osteoarthritis & Arthritis rheumatoid Beli Ketoprofen Novel 100mg tab di K24klik dan rasakan manfaatnya. (k24klik.com)
Flurbiprofen1
- Acceptable predictions were made for Econazole, Methoxsalen, Flurbiprofen and ketoprofen with adjustments to the diffusivity of the stratum corneum. (cdc.gov)
Fenoprofen2
- In addition, a commercial available (fenoprofen) as well as an isotopically labelled (deuterated ketoprofen) standard were investigated as potential internal standards. (joanneum.at)
- Accuracies were 98-113% (fenoprofen) and 95-108% (deuterated ketoprofen), intra-batch precision was 2-3% R.S.D. (fenoprofen) and 2-6% R.S.D. (deuterated ketoprofen), and inter-batch precision was 2-6% R.S.D. (fenoprofen) and 3-6% R.S.D. (deuterated ketoprofen) over the entire quantification range. (joanneum.at)
Effects of ketoprofen2
- Additional studies using the same model in horses have shown that the effects of ketoprofen are maximal by 12 hours and still measurable at 24 hours after each dosage as depicted in the following graph. (nih.gov)
- Accordingly, the goal of this study was to investigate the effects of ketoprofen on ATP synthesis and N assimilation in rice roots. (bvsalud.org)
Inflammation5
- Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. (wikipedia.org)
- KETOFEN® (ketoprofen) is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. (nih.gov)
- Ketoprofen is used for the relief of mild to moderate pain and inflammation. (medscape.com)
- Ketoprofen Injection - commonly used to treat short-term pain, inflammation, and other pains stemming from musculoskeletal disorders. (petscriptpharmacy.com)
- Ketoprofen relieves pain and reduces swelling and inflammation by reducing a substance in the body that leads to inflammation and pain. (pocketpills.com)
Diclofenac1
- This study was intended to valorize a floated sludge of a poultry slaughterhouse using it as a precursor to producing char and activated carbon, which were tested as adsorbents in removing ketoprofen and diclofenac sodium from the water. (bvsalud.org)
Analgesic and antipyretic2
- Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. (wikipedia.org)
- The ketoprofen lysine salt (KLS) has a potent anti-inflammatory activity associated with effective analgesic and antipyretic effects and has a valuable safety profile. (bvsalud.org)
Osteoarthritis2
- There is evidence supporting topical ketoprofen for osteoarthritis but not other chronic musculoskeletal pain. (wikipedia.org)
- Topical formulations of ketoprofen are used to treat minor trauma, tendonitis, small-joint osteoarthritis, acute low-back pain and phlebitis. (famhp.be)
Antipyretic2
- Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of proinflammatory prostaglandin precursors. (wikipedia.org)
- Ketoprofen is a common NSAID, antipyretic, and analgesic used in horses and other equines. (wikipedia.org)
Nonsteroidal1
- Ketoprofen is known as a nonsteroidal anti-inflammatory drug (NSAID). (hellohippo.com)
Topical9
- Ketoprofen topical patches are being used for treatment of musculoskeletal pain. (wikipedia.org)
- Patient with contact dermatitis due to topical application of ketoprofen and sun exposure. (termedia.pl)
- Pharmacokinetic studies of topical ketoprofen formulations using continuous sampling techniques such as microdialysis (MD) or open-flow microperfusion (OFM) require sensitive assays due to small sample volumes. (joanneum.at)
- The presented method was applied to dermal interstitial fluid samples obtained in a topical administration study of ketoprofen in rats. (joanneum.at)
- The EMA confirms the positive benefit / risk balance of ketoprofen-containing medicines for topical use. (famhp.be)
- Following a review of topical formulations of ketoprofen, the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has concluded that the benefit-risk balance of these medicines continues to be positive. (famhp.be)
- The Committee recommended that topical ketoprofen should only be used when prescribed by a physician. (famhp.be)
- Questions and answers on the review of the marketing authorisations for topical formulations of ketoprofen. (famhp.be)
- 2. Topical ketoprofen-containing medicines (creams, gels, solutions and plasters) have been available in all Member States except for the Netherlands since 1978. (famhp.be)
Synthesis1
- Principal component analysis revealed that ketoprofen treatment can significantly affect energy synthesis and nitrogen assimilation in rice roots, while these effects can be alleviated by the antioxidant response. (bvsalud.org)
Orudis1
- Fass environmental information for Orudis (ketoprofen) from Sanofi AB (downloaded 2022-11-16). (janusinfo.se)
Derivatives1
- Six ketoprofen (CAS 22071-15-4) atkylazacycloalkan-2-one ester derivatives (I-VI) were synthesized and evaluated for their anti-inflammatory, analgesic, and ulcerogenic activities after oral administration. (unict.it)
Dose1
- Save yourself the embarrassment of buying Ketoprofen at your local pharmacy, and simply order online Ketoprofen in the dose that you require. (rxbrandmeds.net)
Impurity1
- Buy Ketoprofen Impurity G from GLP Pharma Standards at best competitive price. (glppharmastandards.com)
NSAID2
- Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). (cfspharmacy.pharmacy)
- Ketoprofen, a commonly used non-steroidal anti-inflammatory drug (NSAID), can enter farmland environments via sewage irrigation and manure application and is toxic to plants. (bvsalud.org)
Strains1
- Ketoprofen can also be used to treat pain associated with menstrual cramps and for the relief of pain after surgery (including dental surgery), pain after giving birth, and mild to moderate pain associated with sprains and strains. (pocketpills.com)
Systemic2
- Patient with drug eruption in sun exposed areas associated with systemic use of ketoprofen. (termedia.pl)
- Conclusions: These results suggest that the time course of ketoprofen concentration in synovial fluid is different from plasma concentration time profile after systemic administration of ketoprofen. (korea.ac.kr)
Doses2
- Esters I-VI showed an anti-inflammatory activity, determined as the percent of inhibition of carrageenan-induced edema, similar to that of ketoprofen, although at higher doses. (unict.it)
- Methods: After repeated oral doses of ketoprofen 100 mg twice daily, ketoprofen concentrations of plasma and synovial fluid were determined at steady-state by high performance liquid chromatography(HPLC) in 17 arthritic patients. (korea.ac.kr)
TOXICITY1
- Ketoprofen has high chronic toxicity. (janusinfo.se)
Efficacy1
- ketoprofen, aspirin or other salicylic acid drugs with the same time, can not increase the efficacy of gastrointestinal side effects and increased incidence of bleeding tendency. (china.cn)
Dosage2
- In horses, intravenous dosages of ketoprofen ranging from 0.5 to 1.5 mg/lb resulted in dosage dependent anti-inflammatory effects in the chronic adjuvant carpitis model as depicted in the following graph. (nih.gov)
- Horses were found to tolerate ketoprofen given intravenously at dosages of 0, 1, 3 and 5 mg/lb once daily for 15 consecutive days (up to five times the recommended dosage for three times the usual duration) with no evidence of toxic effects. (nih.gov)
Anti-infla1
- ketoprofen,drinking and other non-steroidal anti-inflammatory drugs used in conjunction, will increase the gastrointestinal side effects, but also cause the risk of ulcers. (china.cn)
Placebo2
- Procedure -Dogs undergoing FHNE were treated with ketoprofen, carprofen, or a placebo for 21 days after surgery. (avma.org)
- Dogs receiving ketoprofen had greater peak propulsive force at a walk on day 3 and greater peak vertical force at a walk on day 15 than did dogs receiving the placebo. (avma.org)
Enzymes1
- Ketoprofen undergoes metabolism in the liver via conjugation with glucuronic acid (glucuronidation) by UGT enzymes, hydroxylation of the benzoyl ring by the CYP3A4 and CYP2C9 enzymes, and reduction of its ketone moiety (a carbonyl functional group, i.e. with carbon-oxygen double bond) by carbonyl reducing enzymes (CREs). (wikipedia.org)
Rheumatoid arthritis1
- Ketoprofen Related Compound D (CAS No: 66067-44-5) Or (3-Acetylbenzophenone), Ketoprofen is a potent non-steroidal anti-inflammatory drug, which is used for the treatment of rheumatoid arthritis and related diseases. (veeprho.com)
Chronic1
- Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. (scientific-publications.net)
Prescription2
- Ketoprofen without prescription. (rxbrandmeds.net)
- You could get Pms Ketoprofen delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. (pocketpills.com)
Pain1
- Ketoprofen is used to relieve pain from various conditions such as dental pain, menstrual cramps, and muscle aches. (hellohippo.com)
Methotrexate1
- ketoprofen should not be used with methotrexate to prevent poisoning. (china.cn)
Drugs1
- Order Ketoprofen drugs on Sale. (rxbrandmeds.net)
Concentration5
- A theoretical study based on Molecular Mechanics and Molecular Dynamics methods is performed to investigate possible surface interactions between the amorphous SiO2 surface and the ketoprofen molecules, an anti-inflammatory drug, considering the role of drug concentration. (mysciencework.com)
- Background: The disposition kinetics of ketoprofen into synovial fluid was estimated to predict the time course of ketoprofen concentration in synovial fluid in patients with arthritis. (korea.ac.kr)
- Plots of plasma ketoprofen concentration against synovial concentration showed anticlockwise hysteresis, suggesting the time delay in the distribution of ketoprofen into synovial fluid from plasma. (korea.ac.kr)
- From the simulation of ketoprofen concentration curves, the predicted C max of synovial fluid was corresponded to 76.6 % of the plasma concentration(1.44 μg/ml vs 1. (korea.ac.kr)
- The results showed that with increasing ketoprofen concentration, root vitality, respiration rate, ATP content, and H+-ATPase activity decreased and plasma membrane permeability increased. (bvsalud.org)
Drug4
- These theoretical results are compared with experimental data obtained by analyzing, through Fourier transform infrared spectroscopy (FT-IR), the interaction between the SiO2 amorphous surface and two percentages of the ketoprofen drug entrapped in a silica matrix obtained via the sol-gel method and dried materials. (mysciencework.com)
- Q. What is a brand name drug Ketoprofen? (rxbrandmeds.net)
- A. A brand name drug Ketoprofen is approved by the Food and Drug Administration (FDA), and is supplied by one company (the pharmaceutical manufacturer). (rxbrandmeds.net)
- Your doctor may have suggested Pms Ketoprofen for conditions other than those listed in these drug information articles. (pocketpills.com)
Consult1
- A prior permission is NOT required but we do recommend you consult a physician before place Ketoprofen ordering. (rxbrandmeds.net)
Exposure3
- However, ketoprofen appears to accumulate more in fish if exposure is effected through wastewater. (janusinfo.se)
- Lis-Święty A, Bergler-Czop B, Trzmiel D. Skin reactions after use of ketoprofen and sun exposure - report of two cases. (termedia.pl)
- Presentation of two cases of skin reactions related to sun exposure after use of ketoprofen. (termedia.pl)
Capsules1
- Ketoprofen short-acting capsules should be taken immediately after a meal or with food to reduce stomach upset. (pocketpills.com)
Significantly1
- Microbiome analysis showed that community diversity and richness of rice root microorganisms in solution increased with increasing levels of ketoprofen treatment, and the microbial community structure and metabolic pathways significantly changed. (bvsalud.org)
Metabolic2
- An interesting observation about most profens including ketoprofen is that they undergo unidirectional metabolic inversion, chiral inversion, of the (R)- acid to its (S)-mirror-image version with no other change in the molecule. (wikipedia.org)
- However, there have been relatively few studies on the association of ketoprofen with nitrogen (N) assimilation and metabolic responses in plants. (bvsalud.org)
