A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
Conditions in which there is histological damage to the lower epidermis along with a grouped chronic inflammatory infiltrate in the papillary dermis disturbing the interface between the epidermis and dermis. LICHEN PLANUS is the prototype of all lichenoid eruptions. (From Rook et al., Textbook of Dermatology, 4th ed, p398)
Facial dermatoses refers to various skin conditions that affect the face, causing symptoms such as redness, inflammation, papules, pustules, scaling, or pigmentation changes, which can be caused by a range of factors including genetics, infections, allergies, and environmental factors.
Any horny growth such as a wart or callus.
Tumors or cancer of the SKIN.
'Skin diseases' is a broad term for various conditions affecting the skin, including inflammatory disorders, infections, benign and malignant tumors, congenital abnormalities, and degenerative diseases, which can cause symptoms such as rashes, discoloration, eruptions, lesions, itching, or pain.
A spontaneous diminution or abatement of a disease over time, without formal treatment.
Eyelid diseases refer to various medical conditions that affect the function, structure, or appearance of the eyelids, including inflammatory, infectious, neoplastic, congenital, and traumatic disorders, which can impact vision, comfort, and overall ocular health.
Tumors of cancer of the EYELIDS.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A surgical technique used primarily in the treatment of skin neoplasms, especially basal cell or squamous cell carcinoma of the skin. This procedure is a microscopically controlled excision of cutaneous tumors either after fixation in vivo or after freezing the tissue. Serial examinations of fresh tissue specimens are most frequently done.
Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.
Operative procedures performed on the SKIN.
A sarcoma of the deep layers of the skin. The tumors are locally aggressive tends to recur but rarely metastatic. It can be classified into variants depending on the cell type tumors are derived from or by its characteristics: Pigmented variant from MELANIN-containing DERMAL DENDRITIC CELLS; Myxoid variant, myxoid STROMAL CELLS; Giant cell variant characterized by GIANT CELLS in the tumors; and Fibrosarcomatous variant chracterized by tumor areas histologically indistinguishable from FIBROSARCOMA.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)

Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. (1/91)

Activated ras genes have been frequently identified in both benign and malignant human tumors, including keratoacanthoma and squamous cell carcinoma. In this study, we developed two lines of transgenic rabbits in which the expression of EJras has been specifically targeted to the rabbit epidermal keratinocytes, using the upstream regulatory region of cottontail rabbit papillomavirus. All of the F1 transgenic progenies developed multiple keratoacanthomas at about 3 days after birth. The rabbits developed an average of 20 tumors, which usually reached the size of approximately 1 cm in diameter and then spontaneously regressed in about 2 months, similar to keratoacanthoma regression in humans. In addition, up to 18% of the rabbits then developed squamous cell carcinoma at about 5 months of age. The expression of EJras was detectable in all of the keratoacanthomas and squamous cell carcinomas. These results strongly support the involvement of the ras oncogene in both the initiation and regression of keratoacanthoma, and in the development of squamous cell carcinomas. These novel transgenic rabbits, with their consistent tumorigenic phenotype at an early age, high similarity to the human lesions, and easy accessibility for examination, manipulation, biopsy, and treatment, should provide a unique model system for studying ras activation-related tumor initiation, regression, and progression, and for evaluating antitumor therapies.  (+info)

Keratoacanthomas have an immunosuppressive cytokine environment of increased IL-10 and decreased GM-CSF compared to squamous cell carcinomas. (2/91)

To investigate the relationship between keratoacanthoma (KA) and squamous cell carcinoma (SCC), cytokine mRNA in 12 KA and eight SCC were compared. Normal skin was also studied. Reverse transcription polymerase chain reaction (RT-PCR) was used to quantitate mRNA in each sample utilizing DNA standards. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal control, and CD3delta as an indication of the T-cell infiltrate. KAs showed a significant increase in interleukin (IL)-10, and a decrease in granulocyte macrophage colony-stimulating factor (GM-CSF) mRNA compared to SCCs. CD3delta mRNA was also increased in the KAs. There was no difference between KAs and SCCs in expression of lymphotoxin-alpha, IL-2, interferon-gamma (IFN-gamma), IL-13, transforming growth factor-beta (TGF-beta), or the pro-inflammatory cytokines IL-8 or tumour necrosis factor-alpha (TNF-alpha). These results indicate that KAs spontaneously resolve in an immunosuppressive environment. KAs grow rapidly over a period of weeks and then involute. It is possible that a suppressed immune response enables unimpeded growth and that the KA cells rapidly undergo the finite number of cell divisions of which they are capable, and then die without reaching immortality.  (+info)

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene. (3/91)

Female CD-1 mice were treated topically with a low (25-50 nmol) or high (800 nmol) dose of benzo[a]pyrene (BP) or acetone vehicle, followed by 5 nmol 12-O-tetradecanoylphorbol 13-acetate (TPA) twice a week for 26 weeks. Selective UV radiation fractionation followed by PCR methods were used to analyze histologically defined subsets of cells (approximately 100-200 cells) on formalin-fixed, paraffin-embedded and H&E stained microscope sections. DNA samples from normal-appearing, hyperplastic or tumor regions from the skin of animals from each treatment group were isolated and amplified by PCR with c-Ha-ras-specific primers. Single-strand conformation polymorphism (SSCP) analyses were performed on both exon 1 and 2 products from each sample. DNA extracted from each aberrant band of SSCP analyses was amplified by PCR for further sequence analysis. The data indicate that c-Ha-ras mutations can be detected in normal-looking and hyperplastic epidermal cells as well as in tumor cells obtained from mice initiated with BP and promoted with TPA. The frequencies of c-Ha-ras mutations for normal-looking, hyperplastic and tumor samples were 3/20 (15%), 8/17 (47%) and 58/68 (85%), respectively, for the low dose group and 8/18 (44%), 10/20 (50%) and 64/86 (74%), respectively, for the high dose group. These observations indicate that there were no dose dependencies in the mutation frequencies for normal-looking, hyperplastic and tumor samples. For combined high dose and low dose samples, differences in mutation frequencies of the c-Ha-ras gene between the normal-looking, hyperplastic and tumor samples were highly significant (P < 0.0001, Fisher's exact test). All mutations detected were located at codons 12, 13 and 61 of the c-Ha-ras gene. With the numbers in parentheses indicating the nucleotide position in the coding sequence of the c-Ha-ras proto-oncogene, the distributions of mutations for G-->A (35), G-->T (35), G-->C (37), G-->T (38), C-->A (181), A-->T (182) and A-->G (182) in the low dose tumors were 5, 2, 11, 74, 0, 7 and 2%, respectively, and the distribution of mutations in tumors from animals treated with a high dose of BP were 3, 7, 13, 61, 15, 1 and 0%, respectively. Differences in the global mutation spectra (site and kind of all mutations) for the c-Ha-ras gene between the high and low dose group tumors were statistically significant (P < 0.004, Fisher's exact test) and the major difference between these two groups was C-->A (181) base substitutions. In summary, our data indicate that: (i) 79% of the BP/TPA skin tumors in CD-1 mice had c-Ha-ras mutations for the combined data for high dose and low dose tumors; (ii) the major mutations detected in BP/TPA skin tumors were G-->T transversions; (iii) the global mutation profile in the c-Ha-ras proto-oncogene in skin tumors obtained after initiation with a low dose of BP was different from that obtained after initiation with a high dose of BP.  (+info)

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin. (4/91)

Benzo[a]pyrene and three arene oxides of benzo[a]pyrene (benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides) have been tested for carcinogenicity in mice by topical application of each compound (0.1 or 0.4 mumol) once every 2 weeks for 60 weeks. At the high dose, benzo[a]pyrene and the 7,8-oxide were highly carcinogenic, whereas the 4,5-oxide (K-region oxide) was weakly active and the 9,10-oxide was inactive. At the low dose, only benzo[a]pyrene was highly carcinogenic. The carcinogenic activities of the three arene oxides of benzo[a]pyrene were not correlated with their stabilities or mutagenic activities.  (+info)

Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. (5/91)

The contribution of the aryl hydrocarbon receptor (AhR) in induction of a battery of xenobiotic-metabolizing enzymes has been studied extensively. However, no direct proof has been obtained that it plays a role in modulating carcinogenesis. To address the question of whether AhR is required for tumor induction, we have investigated the response of AhR-deficient mice to benzo[a]pyrene (B[a]P), a widely distributed environmental carcinogen. B[a]P treatment induced expression of the cytochrome P450 gene Cyp1a1 in the skin and liver of AhR-positive mice bearing +/+ and +/- genotypes and did not induce expression of the cytochrome P450 gene Cyp1a1 in AhR-null mice in either skin or liver. In contrast, Cyp1a2 gene expression was positive in liver irrespective of the presence or absence of the AhR gene, or B[a]P treatment, although its inducibility was lost in the AhR(-/-) mouse. All AhR-positive male mice of both +/+ and +/- genotypes that received subcutaneous injection of B[a]P (2 mg) on the first and the eighth days had developed subcutaneous tumors at the site of injection at the end of the 18-week experiment. In contrast, no tumors were apparent in any of the AhR-deficient mice. Likewise, topical application of B[a]P (200 microg) at weekly intervals to the skin of female mice for 25 weeks produced skin tumors only in the AhR-positive mice. Thus the carcinogenic action of B[a]P may be determined primarily by AhR, a transcriptional regulator of the gene for CYP1A1. The results of the present study provide direct evidence that AhR is involved in carcinogenesis.  (+info)

Comparison of oncostatin M expression in keratoacanthoma and squamous cell carcinoma. (6/91)

Oncostatin M (OSM) is a 28-kDa glycoprotein, produced by stimulated macrophages and T lymphocytes, that inhibits the proliferation and induces differentiation of a number of different cell lines derived from solid tumors. To determine whether keratoacanthoma (KA) is unique or a variant of squamous cell carcinoma (SCC), we compared the immunohistochemical expression of OSM in the tumor cells and peri- and intratumoral macrophages of 21 mature KAs, 7 regressing KAs, and 27 SCCs. An inverse correlation was identified between OSM tumor labeling and the density of OSM-labeled tumor-associated macrophages for KAs (r = -.4; P = .09). OSM tumor expression was significantly more frequent and more intense in KAs than in SCCs (95% versus 63%; P < .01). In contrast, the density of OSM-labeled macrophages was significantly higher in SCCs compared with mature KAs (7/3 high power fields versus 4/3 high power fields; P = .02). These OSM-positive macrophages were predominantly located at the advancing, infiltrative margins of both neoplasms. Regressing KAs demonstrated a decreased level of OSM tumor expression compared with mature KAs (53% versus 95%; P = .001), but there was no difference in density of OSM-labeled macrophages. Both the above differences and the overlapping patterns of OSM expression suggest that KAs are a variant of SCC where OSM, possibly as an autocrine factor, may mediate KA's overwhelming but not absolute tendency to involute.  (+info)

Mucous metaplasia and gap junctions in the vitamin A acid-treated skin tumor, keratoacanthoma. (7/91)

Desmosomes are the usual cell junctions found in normal rabbit epithelium as well as in the untreated keratoacanthoma. This study reports the finding of a second cell junction, the gap junction, when epithelium, normal or tumorous, is subjected to topical applications of vitamin A acid. The gap junction forms early in mucous metaplasia (after 2 days of application of vitamin A acid) and appears before the gross appearance of mucus. The presence of the gap junction occurs when there is an increase in the rough-surfaced endoplasmic reticulum and Golgi cisternae and vesicles. It is possible that the early appearance of the gap junction facilitates and mediates the mucous metaplasia. This suggestion is strengthened by the fact that the gap junction, once present in the mucus-producing tumor, is sparse when the tumor reverts back to the dry, keratotic condition upon cessation of vitamin A acid applications.  (+info)

Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression. (8/91)

Angiotensin II receptors are the specific receptors of angiotensin II of the renin-angiotensin system. The existence and role of the receptors in the skin have not been determined. We immunohistochemically studied the expression of angiotensin receptors in the human skin. The results demonstrated the expression of angiotensin type 1 receptor (AT1) in the normal human suprabasal epidermis. The expression pattern suggests the role of AT1 in association with differentiation. In addition, we studied the expression of AT1 in squamous cell carcinoma (SCC) of the skin, SCC of the lip, and keratoacanthoma (KA). Our experiments showed that high, intermediate, and low levels of AT1 were observed in 37 (74.0%), 7 (14.0%), and 2 (4.0%) of 50 cases of SCC of the skin, respectively, and the negative periphery pattern was observed in 17 (77.3%) of 22 cases of KA. These observations suggest that the immunohistochemical study of AT1 is useful to distinguish SCC from KA. Studying the role and distribution of AT1 may help in understanding the pathophysiology of the skin.  (+info)

Keratoacanthoma is a rapidly growing, dome-shaped, skin tumor that typically arises on sun-exposed areas such as the face, arms, and legs. It is considered a low-grade squamous cell carcinoma (a type of skin cancer) because it shares some characteristics with both benign and malignant tumors.

Keratoacanthomas usually develop over a period of several weeks to months, growing rapidly in size before eventually stabilizing and then gradually regressing on their own within a few months to a year. However, the regression process can take years, and some lesions may not regress completely, leading to cosmetic concerns or even local invasion.

Histologically, keratoacanthomas are characterized by a central keratin-filled crater surrounded by a well-differentiated layer of squamous epithelial cells. The tumor's growth pattern and histological features can make it difficult to distinguish from other types of skin cancer, such as squamous cell carcinoma.

Treatment options for keratoacanthomas include surgical excision, cryosurgery, curettage and electrodesiccation, and topical therapies like imiquimod or 5-fluorouracil. The choice of treatment depends on various factors such as the size, location, and number of lesions, as well as patient preferences and overall health status.

Lichenoid eruptions are skin reactions that resemble the appearance of lichen, a type of slow-growing fungus. These eruptions are characterized by flat, scaly bumps (papules) and rough, discolored patches (plaques) on the skin. They can be caused by various factors, including medications, medical conditions, or as a reaction to certain chemicals or substances that come into contact with the skin.

The term "lichenoid" refers to the resemblance of these eruptions to lichen, which is characterized by its distinctive appearance and growth pattern. Lichenoid eruptions can occur anywhere on the body but are most commonly found on sun-exposed areas such as the arms, legs, and trunk.

The exact cause of lichenoid eruptions can vary, but they are often associated with an autoimmune response in which the body's immune system mistakenly attacks healthy skin cells. This can lead to inflammation, redness, itching, and other symptoms associated with these eruptions. Treatment for lichenoid eruptions typically involves identifying and addressing the underlying cause, as well as managing symptoms with topical medications or other therapies.

Facial dermatoses refer to various skin conditions that affect the face. These can include a wide range of disorders, such as:

1. Acne vulgaris: A common skin condition characterized by the formation of comedones (blackheads and whiteheads) and inflammatory papules, pustules, and nodules. It primarily affects the face, neck, chest, and back.
2. Rosacea: A chronic skin condition that causes redness, flushing, and visible blood vessels on the face, along with bumps or pimples and sometimes eye irritation.
3. Seborrheic dermatitis: A common inflammatory skin disorder that causes a red, itchy, and flaky rash, often on the scalp, face, and eyebrows. It can also affect other oily areas of the body, like the sides of the nose and behind the ears.
4. Atopic dermatitis (eczema): A chronic inflammatory skin condition that causes red, itchy, and scaly patches on the skin. While it can occur anywhere on the body, it frequently affects the face, especially in infants and young children.
5. Psoriasis: An autoimmune disorder that results in thick, scaly, silvery, or red patches on the skin. It can affect any part of the body, including the face.
6. Contact dermatitis: A skin reaction caused by direct contact with an allergen or irritant, resulting in redness, itching, and inflammation. The face can be affected when allergens or irritants come into contact with the skin through cosmetics, skincare products, or other substances.
7. Lupus erythematosus: An autoimmune disorder that can cause a butterfly-shaped rash on the cheeks and nose, along with other symptoms like joint pain, fatigue, and photosensitivity.
8. Perioral dermatitis: A inflammatory skin condition that causes redness, small bumps, and dryness around the mouth, often mistaken for acne. It can also affect the skin around the nose and eyes.
9. Vitiligo: An autoimmune disorder that results in the loss of pigmentation in patches of skin, which can occur on the face and other parts of the body.
10. Tinea faciei: A fungal infection that affects the facial skin, causing red, scaly, or itchy patches. It is also known as ringworm of the face.

These are just a few examples of skin conditions that can affect the face. If you experience any unusual symptoms or changes in your skin, it's essential to consult a dermatologist for proper diagnosis and treatment.

Keratosis, in general, refers to a skin condition characterized by the abnormal growth or development of keratin, a protein that forms part of the outer layer of the skin (epidermis). There are several types of keratosis, including:

1. Seborrheic Keratosis: benign, often pigmented, rough, and scaly growths that can appear anywhere on the body. They tend to increase in number with age.
2. Actinic Keratosis: rough, scaly patches or spots on the skin that are caused by long-term exposure to sunlight or artificial UV light. These have the potential to develop into squamous cell carcinoma, a type of skin cancer.
3. Solar Keratosis: another term for actinic keratosis, as it is primarily caused by sun damage.
4. Keratosis Pilaris: a common condition where small, rough bumps appear on the skin, often on the arms, thighs, or cheeks. These are caused by excess keratin blocking hair follicles.
5. Follicular Keratosis: a disorder characterized by the formation of horny plugs within the hair follicles, leading to rough, sandpaper-like bumps on the skin.
6. Intraepidermal Keratosis: a term used to describe the abnormal accumulation of keratin in the epidermis, which can lead to various skin conditions.

It's important to consult with a healthcare professional or dermatologist for proper diagnosis and treatment if you suspect having any form of keratosis.

Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.

Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.

It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.

Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.

Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.

The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.

It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.

Spontaneous remission in a medical context refers to the disappearance or significant improvement of symptoms of a disease or condition without any specific treatment being administered. In other words, it's a situation where the disease resolves on its own, without any apparent cause. While spontaneous remission can occur in various conditions, it is relatively rare and not well understood. It's important to note that just because a remission occurs without treatment doesn't mean that medical care should be avoided, as many conditions can worsen or lead to complications if left untreated.

Eyelid diseases refer to a variety of medical conditions that affect the function and/or appearance of the eyelids. These can include structural abnormalities, such as entropion (inward turning of the eyelid) or ectropion (outward turning of the eyelid), as well as functional issues like ptosis (drooping of the upper eyelid). Other common eyelid diseases include blepharitis (inflammation of the eyelid margin), chalazion (a blocked oil gland in the eyelid), and cancerous or benign growths on the eyelid. Symptoms of eyelid diseases can vary widely, but often include redness, swelling, pain, itching, tearing, and sensitivity to light. Treatment for these conditions depends on the specific diagnosis and may range from self-care measures and medications to surgical intervention.

Eyelid neoplasms refer to abnormal growths or tumors that develop in the tissues of the eyelids. These growths can be benign (non-cancerous) or malignant (cancerous). Common types of benign eyelid neoplasms include papillomas, hemangiomas, and nevi. Malignant eyelid neoplasms are typically classified as basal cell carcinomas, squamous cell carcinomas, or melanomas. These malignant tumors can be aggressive and may spread to other parts of the body if left untreated. Treatment options for eyelid neoplasms depend on the type, size, and location of the growth, as well as the patient's overall health. Surgical excision is often the preferred treatment approach, although radiation therapy and chemotherapy may also be used in some cases. Regular follow-up care is important to monitor for recurrence or new growths.

Squamous cell carcinoma is a type of skin cancer that begins in the squamous cells, which are flat, thin cells that form the outer layer of the skin (epidermis). It commonly occurs on sun-exposed areas such as the face, ears, lips, and backs of the hands. Squamous cell carcinoma can also develop in other areas of the body including the mouth, lungs, and cervix.

This type of cancer usually develops slowly and may appear as a rough or scaly patch of skin, a red, firm nodule, or a sore or ulcer that doesn't heal. While squamous cell carcinoma is not as aggressive as some other types of cancer, it can metastasize (spread) to other parts of the body if left untreated, making early detection and treatment important.

Risk factors for developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds, fair skin, a history of sunburns, a weakened immune system, and older age. Prevention measures include protecting your skin from the sun by wearing protective clothing, using a broad-spectrum sunscreen with an SPF of at least 30, avoiding tanning beds, and getting regular skin examinations.

Mohs surgery, also known as Mohs micrographic surgery, is a precise surgical technique used to treat common types of skin cancer. It's primarily used for basal cell carcinomas and squamous cell carcinomas that have recurred, are large, aggressive, or in critical areas where preservation of healthy tissue is important, such as the face.

The procedure involves removing the visible tumor along with a thin layer of surrounding tissue. This layer is then processed and examined under a microscope while the patient waits. If cancer cells are found in the margin of the removed tissue, another layer of tissue is taken from that specific area and examined. This process continues until no cancer cells are found in the margins, ensuring complete removal of the tumor while minimizing the removal of healthy tissue.

The main advantage of Mohs surgery is its ability to accurately assess the depth and extent of the cancer, leading to high cure rates and improved cosmetic outcomes. However, it's a specialized procedure that requires extensive training and should be performed by a fellowship-trained Mohs surgeon.

"Frozen sections" is a medical term that refers to the process of quickly preparing and examining a small piece of tissue during surgery. This procedure is typically performed by a pathologist in order to provide immediate diagnostic information to the surgeon, who can then make informed decisions about the course of the operation.

To create a frozen section, the surgical team first removes a small sample of tissue from the patient's body. This sample is then quickly frozen, typically using a special machine that can freeze the tissue in just a few seconds. Once the tissue is frozen, it can be cut into thin slices and stained with dyes to help highlight its cellular structures.

The stained slides are then examined under a microscope by a pathologist, who looks for any abnormalities or signs of disease. The results of this examination are typically available within 10-30 minutes, allowing the surgeon to make real-time decisions about whether to remove more tissue, change the surgical approach, or take other actions based on the findings.

Frozen sections are often used in cancer surgery to help ensure that all of the cancerous tissue has been removed, and to guide decisions about whether additional treatments such as radiation therapy or chemotherapy are necessary. They can also be used in other types of surgeries to help diagnose conditions and make treatment decisions during the procedure.

Dermatologic surgical procedures refer to various types of surgeries performed by dermatologists, which are aimed at treating and managing conditions related to the skin, hair, nails, and mucous membranes. These procedures can be divided into several categories, including:

1. Excisional surgery: This involves removing a lesion or growth by cutting it out with a scalpel. The resulting wound is then closed with stitches, sutures, or left to heal on its own.
2. Incisional biopsy: This is a type of excisional surgery where only a portion of the lesion is removed for diagnostic purposes.
3. Cryosurgery: This involves using extreme cold (usually liquid nitrogen) to destroy abnormal tissue, such as warts or precancerous growths.
4. Electrosurgical procedures: These use heat generated by an electric current to remove or destroy skin lesions. Examples include electrodessication and curettage (ED&C), which involves scraping away the affected tissue with a sharp instrument and then applying heat to seal the wound.
5. Laser surgery: Dermatologic surgeons use various types of lasers to treat a wide range of conditions, such as removing tattoos, reducing wrinkles, or treating vascular lesions.
6. Mohs micrographic surgery: This is a specialized surgical technique used to treat certain types of skin cancer, particularly basal cell carcinomas and squamous cell carcinomas. It involves removing the tumor in thin layers and examining each layer under a microscope until no cancer cells remain.
7. Scar revision surgery: Dermatologic surgeons can perform procedures to improve the appearance of scars, such as excising the scar and reclosing the wound or using laser therapy to minimize redness and thickness.
8. Hair transplantation: This involves removing hair follicles from one area of the body (usually the back of the head) and transplanting them to another area where hair is thinning or absent, such as the scalp or eyebrows.
9. Flap surgery: In this procedure, a piece of tissue with its own blood supply is moved from one part of the body to another and then reattached. This can be used for reconstructive purposes after skin cancer removal or trauma.
10. Liposuction: Dermatologic surgeons may perform liposuction to remove excess fat from various areas of the body, such as the abdomen, thighs, or chin.

Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer that begins in the middle layer of the skin known as the dermis. It often appears as a scar or bruise that does not go away and may grow slowly over time, sometimes spreading to deeper tissues and other parts of the body. DFSP can be difficult to treat if it has spread, but when caught early, it is usually curable with surgery.

DFSP is characterized by the growth of abnormal fibroblasts, which are cells that produce collagen, a protein that helps make up connective tissues in the body. The exact cause of DFSP is not known, but it has been linked to genetic mutations and previous injuries or surgeries to the skin.

Treatment for DFSP typically involves surgical removal of the tumor, along with a margin of healthy tissue around it. In some cases, radiation therapy or targeted therapy may also be used to help ensure that all cancer cells have been removed. Regular follow-up care is important to monitor for any signs of recurrence or spread of the disease.

Carcinoma, basal cell is a type of skin cancer that arises from the basal cells, which are located in the lower part of the epidermis (the outermost layer of the skin). It is also known as basal cell carcinoma (BCC) and is the most common form of skin cancer.

BCC typically appears as a small, shiny, pearly bump or nodule on the skin, often in sun-exposed areas such as the face, ears, neck, hands, and arms. It may also appear as a scar-like area that is white, yellow, or waxy. BCCs are usually slow growing and rarely spread (metastasize) to other parts of the body. However, they can be locally invasive and destroy surrounding tissue if left untreated.

The exact cause of BCC is not known, but it is thought to be related to a combination of genetic and environmental factors, including exposure to ultraviolet (UV) radiation from the sun or tanning beds. People with fair skin, light hair, and blue or green eyes are at increased risk of developing BCC.

Treatment for BCC typically involves surgical removal of the tumor, along with a margin of healthy tissue. Other treatment options may include radiation therapy, topical chemotherapy, or photodynamic therapy. Prevention measures include protecting your skin from UV radiation by wearing protective clothing, using sunscreen, and avoiding tanning beds.

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... strong arguments support classifying keratoacanthoma as a variant of invasive SCC. ... Keratoacanthoma (KA) is a relatively common low-grade tumor that originates in the pilosebaceous glands and closely resembles ... Keratoacanthoma has been reported in all age groups, but incidence increases with age. Keratoacanthoma is rare in persons ... Keratoacanthoma may progress rarely to invasive or metastatic carcinoma. Whether these cases were SCC or keratoacanthoma, the ...
Keratoacanthomas, including multiple eruptive keratoacanthomas, have been described in patients taking BRAF inhibitors such as ... It is thought that the immune system plays a role in spontaneous regression of keratoacanthomas. Most keratoacanthomas are ... In familial keratoacanthomas of Witten and Zak, multiple larger and smaller keratoacanthomas are found. ... Keratoacanthoma See also in: External and Internal Eye,Hair and Scalp. Captions Print Filter Images View all Images (122). ( ...
Keratoacanthoma is most common in fair-skinned older males with a history of chronic sun exposure. ... Keratoacanthoma (KA) is a common, rapidly growing, locally destructive skin tumour. ... Who gets a keratoacanthoma?. Keratoacanthoma is most common in fair-skinned older males with a history of chronic sun exposure ... What causes a keratoacanthoma?. Keratoacanthoma arises from the infundibulum of the hair follicle. The specific pathogenetic ...
... mutilating keratoacanthoma, aggregated keratoacanthoma, the keratoacanthoma centrifugum marginatum (KCM). We present a case of ... Occasionally, multiple keratoacanthomas develop sporadically, such as the eruptive keratoacanthomas of the Grzybowski type or ... 9. Belisario JC: Brief review of keratoacanthomas and description of keratoacanthoma centrifugum marginatum. Aust J Dermatol ... Keratoacanthoma centrifugum marginatum accompanied by extensive granulomatous foreign body reaction.. P Kurschat1, S Hess2, N ...
Information about the SNOMED CT code 58220003 representing Keratoacanthoma of uncertain behavior. ... Keratoacanthoma of uncertain behavior 58220003. SNOMED CT code. SNOMED code. 58220003. name. Keratoacanthoma of uncertain ... Keratoacanthoma of uncertain behavior 58220003. SNOMED CT Concept 138875005. Body structure 123037004. Morphologically altered ... Printed 2023-11-29 from https://www.findacode.com/snomed/58220003--keratoacanthoma.html. Copyright © 2000-2023 InnoviHealth ...
Keratoacanthoma Market Information, by Treatment, end user and by Regions- Forecast to 2030 , Market Research Future (MRFR) ... Keratoacanthoma Market Keratoacanthoma Market Research Report Information,by Treatment (Medication, Surgery - Cryosurgery and ...
Subungual keratoacanthoma: a case report published on Sep 1981 by null. ...
Keratoacanthoma (KA), also known as molluscum sebaceum [1], is a hyperkeratotic dome-shaped nodule that can grow up to ... Subungual keratoacanthomas [9]:. *Multiple Keratoacanthoma [9]: These may be seen in Torres syndrome (Muir-Torre syndrome) ... Keratoacanthoma (KA), also known as molluscum sebaceum [1], is a hyperkeratotic dome-shaped nodule that can grow up to one to ... Eyelid Keratoacanthoma in an 86-Year-Old Man: Clinical and Histopathologic Features. Ophthalmic Plast Reconstr Surg. 2021 May- ...
Supplemental figure 1. A keratoacanthoma lesion before and after application of topical 5% imiquimod cream, three times per ...
Keratoacanthoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional ... Prevention of Keratoacanthoma It is unclear whether keratoacanthoma risk increases with increasing ultraviolet (UV) exposure. ... Etiology of keratoacanthoma is unknown. Most experts consider these lesions to be well-differentiated squamous cell carcinomas ... Keratoacanthomas are round, firm, usually flesh-colored nodules with sharply sloping borders and a characteristic central ...
Keratoacanthoma,squamous cell carcinoma.surgery,surgical,removal, soldering iron,cure.coagulation,thermocoagulation,burning ... en.wikipedia.org/wiki/Keratoacanthoma 2. Ra SH, Su A, Li X, Zhou J, Cochran AJ, Kulkarni RP, Binder SW. Keratoacanthoma and ... Fig.1 Keratoacanthoma of the right cheek on days 7 (left), 28 (center left), 62 (center right) as well as the several cm long ... Fig.3 A keratoacanthoma of the forehead center on day 4 (left) was thermocoagulated the same day. The initially pinhead sized ...
Keratoacanthoma (VisualDX) * Keratosis Pilaris (VisualDX) * Lichen Planus (VisualDX) * Milia (VisualDX) * Notalgia Paresthetica ...
Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization. J Cutan Pathol. 1995 ... Solitary keratoacanthoma is a squamous-cell carcinoma: three examples with metastases. Am J Dermatopathol. 1993 Aug. 15(4):332- ... Keratoacanthoma. J Am Acad Dermatol. 1994 Jan. 30(1):1-19; quiz 20-2. [QxMD MEDLINE Link]. ... Keratoacanthoma. A clinical study. Arch Dermatol. 1984 Jun. 120(6):736-40. [QxMD MEDLINE Link]. ...
2 keratoacanthomas, 1 squamous cell carcinoma); 1 MCPyV-positive perilesional biopsy had a MCPyV-negative counterpart (basal ...
8 keratoacanthomas, 22 actinic keratoses, 3 basal cell carcinomas and 17 SCCs in situ] were sequenced. All samples were ...
Patel MR, Desai S. Subungual keratoacanthoma in the hand. J Hand Surg [Am]. 1989 Jan. 14(1):139-42. [QxMD MEDLINE Link]. ...
Keratoacanthomas. Keratoacanthomas closely resemble squamous cell cancers and many consider them to be a subset of squamous ... In the early stages, keratoacanthomas are smooth, red, and dome shaped.. *Within a few weeks, they can grow rapidly, usually to ...
Immunohistochemical evaluation of serial stored paraffin sections from 42 keratoacanthomas and. Immunohistochemical evaluation ... of serial stored paraffin sections from 42 keratoacanthomas and 11 squamous cell carcinomas demonstrated that skin tumors from ...
Keratoacanthomas and squamous cell carcinomas have been reported previously; however, we report a case of multiple eruptive ... Acitretin 25 mg daily was commenced after few weeks, and no further keratoacanthomas developed during his treatment. We ... We report a 63-year-old Caucasian male who developed multiple cutaneous eruptive keratoacanthomas after starting sorafenib 400& ... Histopathology showed eruptive invasive keratoacanthomas (Grzybowski syndrome). Sorafenib was temporarily stopped and ...
Benign epidermal lesions: seborrheic keratosis, papilloma, keratoacanthoma;. Pigmented eyelid lesions: nevi, melanoma; etc…" ...
Eruptive keratoacanthomas in tattoos. Quinn A, Banney L, Perry-Keene J, Weedon D. Quinn A, et al. Among authors: banney l. ...
Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell CarcinomaLim YH, Fisher JM, Bosenberg MW, Choate KA, Ko CJ ... Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talkZito G, Saotome I, Liu Z ... Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. Journal Of Investigative Dermatology 2016, 136 ... I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. I am also interested in clinical- ...
Malignancies, including squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, Kaposi sarcoma, melanoma ...
Categories: Keratoacanthoma Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 35 ...
... including keratoacanthoma); a cutaneous deposit of lymphoma; or a cutaneous metastasis from an internal malignancy. ...
Keratoacanthoma...167 • Eyelid Laceration...168 • Soft Contact Lenses...169 • Keratoconus...170 • Lymphoproliferative Lesions ...
Keratin and filaggrin expression in keratoacanthoma. J Eur Acad Dermatol Venereol. 2008 Mar; 22(3):353-5. ...
and possibly keratoacanthomas Keratoacanthomas Keratoacanthomas are round, firm, usually pink or flesh-colored growths that ... Some keratoacanthomas may be a form of squamous cell carcinoma. Keratoacanthomas... read more are forms of squamous cell ...
Keratoacanthoma. *Lobular capillary hemangioma (pyogenic granuloma). *Bacterial paronychia. *Subungual exostosis. *Glomus tumor ...
  • 763 Keratoacanthoma centrifugum marginatum is a cutaneous condition, a variant of keratoacanthomas, which is characterized by multiple tumors growing in a localized area. (wikipedia.org)
  • While solitary typical keratoacanthomas are the most common presentation, there are also giant (2-15 cm in diameter), subungual, mucosal, and keratoacanthoma centrifugum marginatum (prominent horizontal growth pattern) variants. (logicalimages.com)
  • According to the histological picture and the clinical course we diagnosed a keratoacanthoma centrifugum marginatum. (cdlib.org)
  • Clinically, three types of the persisting, destructive variant of keratoacanthoma can be distinguished: mutilating keratoacanthoma, aggregated keratoacanthoma, the keratoacanthoma centrifugum marginatum (KCM). (cdlib.org)
  • Keratoacanthoma centrifugum marginatum: an unusual clinical and histopathological diagnostic pitfall. (eyewiki.org)
  • 763 : 644 A solitary keratoacanthoma (also known as "Subungual keratoacanthoma") is a benign, but rapidly growing, locally aggressive tumor which sometimes occur in the nail apparatus. (wikipedia.org)
  • Keratoacanthomas presents as a fleshy, elevated and nodular lesion with an irregular crater shape and a characteristic central hyperkeratotic core. (wikipedia.org)
  • If the entire lesion is removed, the pathologist will probably be able to differentiate between keratoacanthoma and squamous cell carcinoma. (wikipedia.org)
  • Each lesion clinically resembles a solitary keratoacanthoma, and lesions scar with resolution. (logicalimages.com)
  • Keratoacanthomas are usually excised through formal excision, which ensures the lesion is removed completely. (southeastskinclinic.com.au)
  • Aknemycin treatment did not improve the situation, the lesion continued growing, no pus was formed and the lesion measured around 4mm in diameter by day 7 ( fig.2 top left ), suggesting a second keratoacanthoma. (classimed.de)
  • Keratoacanthoma SYMPTOMS Usually asymptomatic, possible irritation SIGNS Dome-shaped lesion, rolled edges, central plug WORK-UP Thorough history. (odclinicals.com)
  • 667, 764 : 644 Generalized eruptive keratoacanthoma (also known as "Generalized eruptive keratoacanthoma of Grzybowski") is a cutaneous condition, a variant of keratoacanthomas, characterized by hundreds to thousands of tiny follicular keratotic papules over the entire body. (wikipedia.org)
  • There is a rare generalized eruptive keratoacanthoma of Grzybowski. (medscape.com)
  • In eruptive keratoacanthomas of Grzybowski, hundreds of lesions occur in a generalized distribution and may involve mucous membranes. (logicalimages.com)
  • Occasionally, multiple keratoacanthomas develop sporadically, such as the eruptive keratoacanthomas of the Grzybowski type or in the context of familial syndromes like the Ferguson-Smith syndrome or the Muir-Torre syndrome. (cdlib.org)
  • however, we report a case of multiple eruptive keratoacanthomas in the form of Grzybowski syndrome after initiation of sorafenib. (biomedcentral.com)
  • Histopathology showed eruptive invasive keratoacanthomas (Grzybowski syndrome). (biomedcentral.com)
  • however, generalized eruptive keratoacanthomas (Grzybowski syndrome) related to sorafenib has not been previously identified. (biomedcentral.com)
  • We report a patient who developed multiple keratoacanthomas consistent with Grzybowski syndrome after initiation of sorafenib therapy. (biomedcentral.com)
  • Keratoacanthomas, including multiple eruptive keratoacanthomas, have been described in patients taking BRAF inhibitors such as vemurafenib and dabrafenib. (logicalimages.com)
  • We report a 63-year-old Caucasian male who developed multiple cutaneous eruptive keratoacanthomas after starting sorafenib 400 mg twice daily. (biomedcentral.com)
  • A 63-year-old Caucasian male with known hepatocellular carcinoma presented with multiple cutaneous eruptive keratoacanthomas approximately three and half months after starting sorafenib 400 mg twice daily. (biomedcentral.com)
  • Eruptive keratoacanthomas in tattoos. (nih.gov)
  • In contrast to squamous cell carcinomas, keratoacanthomas appear and grow rapidly over the course of a few weeks to a month. (logicalimages.com)
  • Squamous cell carcinomas develop rather slowly without pain, while Keratoacanthomas grow fast and show pressure pain. (classimed.de)
  • Whole genome amplified DNA (not amplified by any specific PCR primers) from 91 skin lesions [41 squamous cell skin carcinomas (SCCs), 8 keratoacanthomas, 22 actinic keratoses, 3 basal cell carcinomas and 17 SCCs in situ] were sequenced. (nih.gov)
  • Immunohistochemical evaluation of serial stored paraffin sections from 42 keratoacanthomas and 11 squamous cell carcinomas demonstrated that skin tumors from UVB-exposed mice showed an inverse relationship (>95%) between p53 protein expression and phospho-Chk1 (Ser317) however not phospho-Chk1 (Ser345) protein expression. (technologybooksindustrialprojectreports.com)
  • Inhalation of 1-BP produced alveolar/bronchiolar adenomas and carcinomas in female mice, adenomas of the large intestine in female rats, and keratoacanthoma/squamous cell carcinoma of the skin in male rats. (cdc.gov)
  • 763 : 645 Multiple keratoacanthomas (also known as "Ferguson-Smith syndrome," "Ferguson-Smith type of multiple self-healing keratoacanthomas,") is a cutaneous condition, a variant of keratoacanthomas, which is characterized by the appearance of multiple, sometimes hundreds of keratoacanthomas. (wikipedia.org)
  • In familial keratoacanthomas of Witten and Zak, multiple larger and smaller keratoacanthomas are found. (logicalimages.com)
  • Multiple familial keratoacanthoma of Witten and Zak. (dermnetnz.org)
  • Keratoacanthomas typically present as a solitary, rapidly growing nodule on sun- exposed skin of the face and upper limbs. (dermnetnz.org)
  • Approximately 98 percent of keratoacanthomas fall into the classic, solitary type that mainly occurs in elderly persons on exposed areas. (cdlib.org)
  • Epidemiologic data of keratoacanthoma is notably similar to SCC and Bowen disease (SCC in situ) concerning age, sex, and the anatomic site of lesions. (medscape.com)
  • Keratoacanthoma (KA) is a relatively common low-grade tumor that originates in the pilosebaceous glands and closely resembles squamous cell carcinoma (SCC). (medscape.com)
  • Keratoacanthoma is a rapidly-growing tumor, which histologically resembles squamous cell carcinoma. (korea.ac.kr)
  • The tumor was successfully removed without relapse and identified again as squamous cell carcinoma with differential diagnosis keratoacanthoma although its clinical development ressembled more to a keratoacanthoma. (classimed.de)
  • I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma. (yale.edu)
  • Although it may regress spontaneously, keratoacanthoma is routinely treated by excision. (korea.ac.kr)
  • The tissue was identified as squamous cell carcinoma with Keratoacanthoma as differential diagnosis and surgical excision was recommended. (classimed.de)
  • Many new treatments for melanoma are also known to increase the rate of keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. (wikipedia.org)
  • Twenty percent of patients who had metastatic melanoma and were treated with vemurafenib, a novel BRAF V600E inhibitor, may develop eruptive keratoacanthoma or squamous cell carcinoma. (medscape.com)
  • If left untreated, most keratoacanthomas spontaneously involute and resolve within 6 months, leaving an atrophic scar. (logicalimages.com)
  • On the trunk, arms, and legs, electrodesiccation and curettage often suffice to control keratoacanthomas until they regress. (wikipedia.org)
  • 763-764 : 643-646 Giant keratoacanthomas are a variant of keratoacanthoma, which may reach dimensions of several centimeters. (wikipedia.org)
  • We suggest that intralesional injection of methotrexate is an effective and non-operative modality for the treatment of giant keratoacanthoma. (korea.ac.kr)
  • The introduction of BRAF inhibitor therapy for melanoma and hedgehog pathway inhibitor therapy for advanced basal cell carcinoma have elicited a surge in keratoacanthoma (KA) incidence. (medscape.com)
  • There is no single histological finding that can characterize keratoacanthoma. (eyewiki.org)
  • Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin tumour that is believed to originate from the hair follicle (pilosebaceous unit) and can resemble squamous cell carcinoma. (wikipedia.org)
  • Under the microscope, keratoacanthoma very closely resembles squamous cell carcinoma. (wikipedia.org)
  • some pathologists may label KA as "well-differentiated squamous cell carcinoma, keratoacanthoma variant", and prompt definitive surgery may be recommended. (wikipedia.org)
  • Frequently reported and reclassified over the last century, keratoacanthoma can be divided into various subtypes and despite being considered benign, their unpredictable behaviour has warranted the same attention as with squamous cell carcinoma. (wikipedia.org)
  • Keratoacanthoma may progress rarely to invasive or metastatic carcinoma. (medscape.com)
  • Keratoacanthomas may occur within Muir-Torre syndrome along with sebaceous neoplasms and adenomatous colon carcinoma or other low-grade internal malignancies. (logicalimages.com)
  • Keratoacanthoma has many similarities with SCC (Squamous Cell Carcinoma) and is often very difficult to tell apart, both clinically and pathologically. (southeastskinclinic.com.au)
  • A keratoacanthoma & Squamous Cell carcinoma may look similar - at first glance - to the pathologist. (southeastskinclinic.com.au)
  • The distinction beteen squamous cell carcinoma and keratoacanthoma by morphological criteria is difficult ( 1 ) in contrast to the comparatively clear discrimination by molecular biological analysis ( 2 ). (classimed.de)
  • I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. (yale.edu)
  • Some keratoacanthomas may be a form of squamous cell carcinoma. (merckmanuals.com)
  • and 3.73 (1.44) ppm for keratoacanthoma +squamous cell carcinoma of the skin. (cdc.gov)
  • In fact, strong arguments support classifying keratoacanthoma as a variant of invasive SCC. (medscape.com)
  • We present this case because of the strong granulomatous foreign body reaction which might complicate the diagnosis and has not been described for this keratoacanthoma variant so far. (cdlib.org)
  • Keratoacanthomas are common benign epidermal tumors characterized by the rapid development of a firm, symmetrical dome-shaped nodule with a horn-filled crater in its center and a tendency for spontaneous regression. (cdlib.org)
  • Keratoacanthoma (or simply 'KA') is a benign tumour of the sebaceous gland that develops as a red or skin-coloured spot and grows rapidly over a few weeks. (southeastskinclinic.com.au)
  • Keratoacanthomas are squamous cell neoplasms known to be abundant in epidermal growth factor receptors (EGFRs). (uky.edu)
  • Keratoacanthoma and conventional SCC share very similar epidemiological features, which suggests a possible common pathogenesis, such as actinic damage. (medscape.com)
  • These data strongly support a common etiology among keratoacanthoma, SCC, and Bowen disease. (medscape.com)
  • Etiology of keratoacanthoma is unknown. (msdmanuals.com)
  • In addition to the main type, several variants of keratoacanthoma exist and are characterized by lack of spontaneous regression and progressive destructive growth. (cdlib.org)
  • It is thought that the immune system plays a role in spontaneous regression of keratoacanthomas. (logicalimages.com)
  • A keratoacanthoma is a rapidly growing, well-differentiated neoplasm of squamous epithelium. (logicalimages.com)
  • Keratoacanthomas typically turn into scar tissue over time. (southeastskinclinic.com.au)
  • Fig.1 Keratoacanthoma of the right cheek on days 7 ( left ), 28 ( center left ), 62 ( center right ) as well as the several cm long scar 48months after surgical removal on 66.Tag ( right ) (click on images for enlargement). (classimed.de)
  • [ 10 ] Keratoacanthoma is commonly associated with syndromes such as Muir-Torre syndrome, Ferguson-Smith syndrome, xeroderma pigmentosum, and incontinentia pigmenti. (medscape.com)
  • It is unclear whether keratoacanthoma risk increases with increasing ultraviolet (UV) exposure. (msdmanuals.com)
  • Keratoacanthomas Keratoacanthomas are round, firm, usually pink or flesh-colored growths that have a central crater that is scaly or crusted. (merckmanuals.com)
  • Additional skin cancers include sebaceous epitheliomas and keratoacanthomas. (ccalliance.org)
  • Acitretin 25 mg daily was commenced after few weeks, and no further keratoacanthomas developed during his treatment. (biomedcentral.com)
  • Temporary interruption and dose reduction of sorafenib and use of acitretin appeared to prevent further development of keratoacanthomas. (biomedcentral.com)
  • Keratoacanthomas have also been associated with vismodegib and sorafenib use. (logicalimages.com)
  • Keratoacanthoma is commonly found on sun-exposed skin, often face, forearms and hands. (wikipedia.org)
  • Keratoacanthoma (KA), also known as molluscum sebaceum [1] , is a hyperkeratotic dome-shaped nodule that can grow up to one to three centimeters within a few months. (eyewiki.org)
  • Keratoacanthomas usually occurs in older individuals. (wikipedia.org)
  • Ferguson-Smith syndrome is an autosomal dominant inherited disease characterized by multiple self-healing keratoacanthomas. (logicalimages.com)
  • Keratoacanthomas are sharply demarcated , firm, erythematous or skin-coloured, with a classic central hyperkeratotic plug and an even shoulder. (dermnetnz.org)
  • What are the clinical features of a keratoacanthoma? (dermnetnz.org)
  • Keratoacanthomas are much less common in patients with skin of colour, but the clinical features are the same. (dermnetnz.org)
  • Skin injury may also be a predisposing factor, as there are many reports of keratoacanthomas developing in sites of previous trauma, in surgical scars, after laser resurfacing, and following radiation therapy. (logicalimages.com)
  • The defining characteristic of a keratoacanthoma is that it is dome-shaped, symmetrical, surrounded by a smooth wall of inflamed skin, and capped with keratin scales and debris. (wikipedia.org)
  • Keratoacanthoma may be difficult to distinguish visually from a skin cancer. (wikipedia.org)

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