Isoflavones. Medical search. Web

3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.

Proteins which are present in or isolated from SOYBEANS.

An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.

Foods made from SOYBEANS. Health benefits are ascribed to the high levels of DIETARY PROTEINS and ISOFLAVONES.

PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.

A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

A beverage prepared from SOYBEANS.

A plant genus of the family FABACEAE a common weed of the southeast US. There has been folk use for alcoholism and liver protection. It contains puerarin, kakkalide, daidzein (isoflavonoids), and kudzusaponins (oleanene-type triterpene glycosides).

A plant genus of the family FABACEAE.

Non-steroidal compounds with estrogenic activity.

Material prepared from plants.

Regular course of eating and drinking adopted by a person or animal.

A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.

The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.

A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.

Proteins which are present in or isolated from vegetables or vegetable products used as food. The concept is distinguished from PLANT PROTEINS which refers to non-dietary proteins from plants.

The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.

Use of plants or herbs to treat diseases or to alleviate pain.

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.

A group of phenyl benzopyrans named for having structures like FLAVONES.

A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.

A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.

Benzopyrans saturated in the 2 and 3 positions.

The surgical removal of one or both ovaries.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. (1/1619)

Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition. DG and GG were synthesized using 3-methylcholanthrene-induced rat liver microsomes. The Km and Vmax for daidzein and genistein were 9.0 and 7.7 micromol/L, and 0.7 and 1.6 micromol/(mg protein. min), respectively. The absence of ultraviolet absorbance maxima shifts in the presence of sodium acetate confirmed that the synthesized products were 7-O-glucuronides. DG and GG were further purified by a Sephadex LH-20 column. DG and GG competed with the binding of 17beta-(3H) estradiol to estrogen receptors of B6D2F1 mouse uterine cytosol. The concentrations required for 50% displacement of 17beta-(3H) estradiol (CB50) were: 17beta-estradiol, 1.34 nmol/L; diethylstilbestrol, 1.46 nmol/L; daidzein, 1.6 micromol/L; DG, 14.7 micromol/L; genistein, 0.154 micromol/L; GG, 7.27 micromol/L. In human peripheral blood NK cells, genistein at <0.5 micromol/L and DG and GG at 0.1-10 micromol/L enhanced NK cell-mediated K562 cancer cell killing significantly (P < 0.05). At > 0.5 micromol/L, genistein inhibited NK cytotoxicity significantly (P < 0.05). The glucuronides only inhibited NK cytotoxicity at 50 micromol/L. Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively. At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action. (+info)

Dietary isoflavones: biological effects and relevance to human health. (2/1619)

Substantial evidence indicates that diets high in plant-based foods may explain the epidemiologic variance of many hormone-dependent diseases that are a major cause of mortality and morbidity in Western populations. There is now an increased awareness that plants contain many phytoprotectants. Lignans and isoflavones represent two of the main classes of phytoestrogens of current interest in clinical nutrition. Although ubiquitous in their occurrence in the plant kingdom, these bioactive nonnutrients are found in particularly high concentrations in flaxseeds and soybeans and have been found to have a wide range of hormonal and nonhormonal activities that serve to provide plausible mechanisms for the potential health benefits of diets rich in phytoestrogens. Data from animal and in vitro studies provide convincing evidence for the potential of phytoestrogens in influencing hormone-dependent states; although the clinical application of diets rich in these estrogen mimics is in its infancy, data from preliminary studies suggest beneficial effects of importance to health. This review focuses on the more recent studies pertinent to this field and includes, where appropriate, the landmark and historical literature that has led to the exponential increase in interest in phytoestrogens from a clinical nutrition perspective. (+info)

Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. (3/1619)

Genistein and daidzein are biologically active isoflavones that are especially abundant in soybeans. After intestinal absorption, circulating genistein and daidzein are eliminated primarily by the kidneys. This study was undertaken to assess the metabolism of genistein and daidzein in patients with end-stage renal disease (ESRD) on hemodialysis therapy, and to test whether this treatment modality can replace the lack of kidney function, with respect to the elimination of the isoflavones. Twenty-three hemodialysis patients and 10 healthy subjects were studied. While consuming a self-selected low isoflavone diet, baseline blood levels were undetectable in eight of 10 healthy subjects and in 14 of 23 dialysis patients. The remaining participants had detectable levels, with the nine dialysis patients displaying much higher blood concentrations than the two healthy control subjects. After the evening intake of one dose of an isoflavone-rich soy protein isolate drink, the early morning blood levels of genistein and daidzein were higher in seven dialysis patients than in eight healthy subjects (genistein 1271+/-321 versus 425+/-104, P<0.05; daidzein 1304+/-352 versus 292+/-78, P<0.05). The blood clearance of the isoflavones was studied in two healthy subjects and in three dialysis patients. Genistein and daidzein were eliminated within 2 d in the healthy subjects, but had not returned to baseline in two of three ESRD patients, 7 d after intake. The half-life of both compounds was estimated to be 10-fold longer in the ESRD patients than in the healthy subjects. Finally, genistein and daidzein levels were measured before and after dialysis in five patients, both while on their regular diet and after one dose of a soy protein isolate drink. In both instances, the dialysis treatment did not affect the blood isoflavone levels. In conclusion, approximately one-third of hemodialysis patients eating the standard American renal diet experience high blood levels of the isoflavones genistein and daidzein, while the remaining two-thirds have undetectable levels. After ingestion of isoflavone-rich food such as soy products, all patients have detectable levels that remain very high for several days due to lack of renal excretion. (+info)

Daidzein and genistein but not their glucosides are absorbed from the rat stomach. (4/1619)

Absorption of isoflavone aglycones and glucosides was compared in rats. Daidzein, genistein, daidzin and genistin were orally administered at a dose of 7.9 micromol/kg in 25 mM Na2CO3 and next their metabolite concentration in blood plasma was monitored for 30 min. After isoflavone glucosides administration, their metabolites appeared in plasma with a few minutes delay as compared to aglycones, which suggested that aglycones, but not glucosides, were absorbed already in the rat stomach. This observation was confirmed when absorption site was restricted solely to the stomach and absorption was shown to be independent of the vehicle pH used for administration. (+info)

Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity. (5/1619)

Glycitein metabolism was compared with other isoflavones to begin to understand the effect of this compound. Total isoflavones of 4.5 micromol/kg body weight from soymilk (high in genistein and daidzein) and soygerm (high in daidzein and glycitein) was fed to seven women and seven men. To minimize interindividual variation, only subjects with moderate fecal isoflavone degradation rates (half-lives of daidzein and genistein were 15.7 and 8.9 h, respectively) were included. The average 48-h urinary excretion of glycitein, daidzein and genistein was approximately 55, 46 and 29% of the dose ingested, respectively, which was significantly different from each other in men and women (P < 0.001). Plasma isoflavone concentrations at 6 and 24 h after soymilk feeding paralleled relative amounts of isoflavones in soymilk (genistein > daidzein > glycitein) (P < 0.05) in men and women, but plasma isoflavone concentrations after soygerm feeding did not parallel soygerm isoflavone concentrations in women because genistein and glycitein did not differ from each other at 6 h after feeding. Six hours after soygerm dosing, plasma isoflavone concentrations paralleled soygerm isoflavone levels in men. Based on plasma isoflavone concentrations at 6 h after dosing, the bioavailabilities of daidzein and genistein were similar in men and women. At the high glycitein dose (soygerm), plasma concentration at 24 h after dosing suggested a modest gender difference in glycitein bioavailability. (+info)

Soybean isoflavones reduce experimental metastasis in mice. (6/1619)

We investigated the effect of dietary supplementation with isoflavones on pulmonary metastasis of B16BL6 murine melanoma cells in C57BL/6 mice. Mice were fed a basal AIN-93G diet or the basal diet supplemented with the isoflavones genistein and daidzein at 113 micromol/kg, 225 micromol/kg, 450 micromol/kg, or 900 micromol/kg for 2 wk before and after the intravenous injection of 0.5 x 10(5) melanoma cells. At necropsy, the number and size of tumors that formed in the lungs were determined. The number of mice that had >15 lung tumors was 17 in the control group, and 16, 15, 13, and 10 in the groups fed isoflavones at 113 micromol/kg, 225 micromol/kg, 450 micromol/kg and 900 micromol/kg, respectively. The latter two were significantly different from the control (P +info)

Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein. (7/1619)

In the presence of ATP, genistein, like the ATP analogue adenosine 5'-[beta,gamma-imido]triphosphate (pp[NH]pA), increases cystic fibrosis transmembrane conductance regulator (CFTR) chloride currents by prolonging open times. As pp[NH]pA is thought to increase CFTR currents by interfering with ATP hydrolysis at the second nucleotide-binding fold (NBF-2), the present study was undertaken to investigate the effects of genistein on a fusion protein comprising maltose-binding protein (MBP) and NBF-2 (MBP-NBF-2). MBP-NBF-2 exhibited ATPase, GTPase and adenylate kinase activities that were inhibited by genistein in a partial non-competitive manner with respect to ATP or GTP. Ki values for competitive and uncompetitive inhibition were respectively 20 microM and 63 microM for ATPase, 15 microM and 54 microM for GTPase, and 46 microM and 142 microM for adenylate kinase. For ATPase activity, genistein reduced Vmax by 29% and Vmax/Km by 77%. Additional evidence for complex-formation between genistein and MBP-NBF-2 was obtained by the detection of genistein-dependent alterations in the CD spectrum of MBP-NBF-2 that were consistent with the formation of a higher-ordered state. Addition of MBP-NBF-2 increased the fluorescence intensity of genistein, consistent with a change to a less polar environment. pp[NH]pA partially eliminated this enhanced fluorescence of genistein. These observations provide the first direct biochemical evidence that genistein interacts with CFTR, thus inhibiting NBF-2 activity, and suggest a similar mechanism for genistein-dependent stimulation of CFTR chloride currents. (+info)

Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. (8/1619)

Macrophage-mediated oxidation of low density lipoprotein (LDL) is considered to be of major importance in early atherogenesis; therefore, intervention means to inhibit this process are being extensively studied. In the present study, we questioned the ability of the isoflavan glabridin (from licorice) to accumulate in macrophages and to affect cell-mediated oxidation of LDL. We first performed in vitro studies, using mouse peritoneal macrophages (MPMs) and the J-774 A.1 macrophage-like cell line. Both cells accumulated up to 1.5 micrograms of glabridin/mg of cell protein after 2 h of incubation, and this process was time- and glabridin dose-dependent. In parallel, in glabridin-enriched cells, macrophage-mediated oxidation of LDL was inhibited by up to 80% in comparison with control cells. Glabridin inhibited superoxide release from MPMs in response to phorbol 12-myristate 13-acetate, or to LDL when added together with copper ions, by up to 60%. Translocation of P-47, a cytosolic component of NADPH oxidase to the plasma membrane was substantially inhibited. In glabridin-enriched macrophages, protein kinase C activity reduced by approximately 70%. All of the above effects of glabridin required the presence of the two hydroxyl groups on the flavonoid's B phenol ring. In order to assess the physiological significance of these results, we next performed in vivo studies, using the atherosclerotic apolipoprotein E-deficient (E0) mice. MPMs harvested from glabridin-treated E0 mice (20 micrograms/mouse/day for a period of 6 weeks) demonstrated reduced capability to oxidize LDL by 80% in comparison with placebo-treated mice. This latter phenomenon was associated with a reduction in the lesion oxysterols and a 50% reduction in the aortic lesion size. We thus conclude that glabridin accumulation in macrophages is associated with reduced cell-mediated oxidation of LDL and decreased activation of the NADPH oxidase system. These phenomena could be responsible for the attenuation of atherosclerosis in E0 mice, induced by glabridin. (+info)

Isoflavones are a type of plant-derived compounds called phytoestrogens, which have a chemical structure similar to human estrogen. They are found in various plants, particularly in soybeans and soy products. Isoflavones can act as weak estrogens or anti-estrogens in the body, depending on the levels of natural hormones present. These compounds have been studied for their potential health benefits, including reducing menopausal symptoms, improving cardiovascular health, and preventing certain types of cancer. However, more research is needed to fully understand their effects and safety.

Soybean proteins are the proteins derived from soybeans, a legume native to East Asia. Soybeans contain approximately 40% protein by weight, making them a significant source of plant-based protein. The two major types of soy protein are:

1. Soy protein isolate (SPI): This is a highly refined protein that contains at least 90% protein by weight. It is made by removing carbohydrates and fiber from defatted soy flour, leaving behind a protein-rich powder. SPI is often used as an ingredient in various food products, including meat alternatives, energy bars, and beverages.
2. Soy protein concentrate (SPC): This type of soy protein contains approximately 70% protein by weight. It is made by removing some of the carbohydrates from defatted soy flour, leaving behind a higher concentration of proteins. SPC has applications in food and industrial uses, such as in textured vegetable protein (TVP) for meat alternatives, baked goods, and functional foods.

Soy proteins are considered high-quality proteins due to their complete amino acid profile, containing all nine essential amino acids necessary for human nutrition. They also have various health benefits, such as lowering cholesterol levels, improving bone health, and promoting muscle growth and maintenance. However, it is important to note that soy protein consumption should be balanced with other protein sources to ensure a diverse intake of nutrients.

I'm sorry for any confusion, but "soybeans" are not a medical term. They are a type of legume that is commonly used in agriculture and food production. The medical community might discuss soybeans in the context of nutrition or allergies, but there isn't a formal medical definition for this term.

Here's some general information: Soybeans, scientifically known as Glycine max, are native to East Asia and are now grown worldwide. They are a significant source of plant-based protein and oil. Soybeans contain various nutrients, including essential amino acids, fiber, B vitamins, and minerals like calcium, iron, magnesium, and zinc. They are used in various food products such as tofu, soy milk, tempeh, and miso. Additionally, soybeans are also used in the production of industrial products, including biodiesel, plastics, and inks. Some people may have allergic reactions to soybeans or soy products.

Soy foods are food products made from soybeans, which are a rich source of plant-based protein, fiber, and various beneficial compounds like isoflavones. Examples of soy foods include tofu, tempeh, soymilk, edamame (immature soybeans), soy flour, and textured vegetable protein (TVP). Soy products can be used as alternatives to animal-based proteins and can be incorporated into a variety of dishes, such as stir-fries, soups, smoothies, and baked goods. It's important to note that some people may have allergies to soy or sensitivities to its phytoestrogens, which can affect hormone balance in the body.

Phytoestrogens are compounds found in plants that have estrogen-like properties. They can bind to and activate or inhibit the action of estrogen receptors in the body, depending on their structure and concentration. Phytoestrogens are present in a variety of foods, including soy products, nuts, seeds, fruits, and vegetables.

Phytoestrogens have been studied for their potential health benefits, such as reducing the risk of hormone-dependent cancers (e.g., breast cancer), improving menopausal symptoms, and promoting bone health. However, their effects on human health are complex and not fully understood, and some studies suggest that high intake of phytoestrogens may have adverse effects in certain populations or under specific conditions.

It is important to note that while phytoestrogens can mimic the effects of estrogen in the body, they are generally weaker than endogenous estrogens produced by the human body. Therefore, their impact on hormonal balance and health outcomes may vary depending on individual factors such as age, sex, hormonal status, and overall diet.

Equol is a metabolite produced by intestinal bacteria that can metabolize the soy isoflavone daidzein. It has been studied for its potential role in various health outcomes, such as reducing menopause symptoms and protecting against certain types of cancer. However, not all individuals have the ability to produce equol, and its effects on human health are still a subject of ongoing research.

Genistein is defined as a type of isoflavone, which is a plant-derived compound with estrogen-like properties. It is found in soybeans and other legumes. Genistein acts as a phytoestrogen, meaning it can bind to estrogen receptors and have both weak estrogenic and anti-estrogenic effects in the body.

In addition to its estrogenic activity, genistein has been found to have various biological activities, such as antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its potential role in preventing or treating a variety of health conditions, including cancer, cardiovascular disease, osteoporosis, and menopausal symptoms. However, more research is needed to fully understand the potential benefits and risks of genistein supplementation.

Soy milk is not a medical term, but it is a common term used to describe a plant-based milk alternative made from soybeans. Here's a brief description:

Soy milk is a beverage produced by soaking and grinding soybeans, then filtering the resulting mixture to remove solid particles. It is often consumed as a dairy substitute by individuals who are lactose intolerant or have milk allergies. Soy milk contains protein, carbohydrates, and fat, similar to cow's milk, but its nutritional profile may vary depending on the manufacturing process. Some brands of soy milk are fortified with calcium, vitamins B12, D, and riboflavin (B2) to resemble the nutritional content of cow's milk.

Please note that while soy milk can be a healthy alternative for many people, it may not be suitable for everyone, especially those with soy allergies or sensitivities. If you have any concerns about incorporating soy milk into your diet, consult a healthcare professional or a registered dietitian.

"Pueraria" is a genus of plants in the legume family, Fabaceae. The most commonly known species is Pueraria lobata, also called kudzu or Japanese arrowroot. This plant is native to East Asia and has been used in traditional medicine for various purposes such as treating alcoholism, fever, and inflammation.

In a medical context, "Pueraria" may refer to the use of extracts from this plant in dietary supplements or alternative medicine practices. Some studies have suggested that certain compounds found in Pueraria, such as isoflavones, may have potential health benefits, but more research is needed to confirm these effects and establish safe and effective dosages.

It's important to note that while some natural products containing Pueraria extracts may be marketed for various health purposes, they should not be used as a substitute for conventional medical care or treatment. It's always best to consult with a healthcare provider before starting any new supplement regimen.

"Trifolium" is not a medical term. It is actually the genus name for a group of plants commonly known as clover. These plants belong to the family Fabaceae and are found in many temperate regions around the world. Some species, like red clover (Trifolium pratense), are used in herbal medicine for various purposes, such as treating respiratory conditions, skin inflammations, and menopausal symptoms. However, it's important to consult with a healthcare professional before using any herbal remedies.

Non-steroidal estrogens are a class of compounds that exhibit estrogenic activity but do not have a steroid chemical structure. They are often used in hormone replacement therapy and to treat symptoms associated with menopause. Examples of non-steroidal estrogens include:

1. Phytoestrogens: These are plant-derived compounds that have estrogenic activity. They can be found in various foods such as soy, nuts, seeds, and some fruits and vegetables.
2. Selective Estrogen Receptor Modulators (SERMs): These are synthetic compounds that act as estrogen receptor agonists or antagonists, depending on the target tissue. Examples include tamoxifen, raloxifene, and toremifene. They are used in the treatment of breast cancer and osteoporosis.
3. Designer Estrogens: These are synthetic compounds that have been specifically designed to mimic the effects of estrogen. They are often used in research but have not been approved for clinical use.

It is important to note that non-steroidal estrogens can also have side effects and risks, including an increased risk of certain types of cancer, cardiovascular disease, and thromboembolic events. Therefore, their use should be carefully monitored and managed by a healthcare professional.

"Plant preparations" is not a term with a specific medical definition in the field of medicine or pharmacology. However, it is commonly used to refer to various forms of plant material that have been prepared for medicinal use. This can include dried and powdered plant parts, such as leaves, roots, or flowers, as well as extracts or concentrates made from plants. These preparations may be used in traditional medicine or as the basis for modern pharmaceuticals. It is important to note that the safety, effectiveness, and quality of plant preparations can vary widely, and they should only be used under the guidance of a qualified healthcare provider.

A diet, in medical terms, refers to the planned and regular consumption of food and drinks. It is a balanced selection of nutrient-rich foods that an individual eats on a daily or periodic basis to meet their energy needs and maintain good health. A well-balanced diet typically includes a variety of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.

A diet may also be prescribed for therapeutic purposes, such as in the management of certain medical conditions like diabetes, hypertension, or obesity. In these cases, a healthcare professional may recommend specific restrictions or modifications to an individual's regular diet to help manage their condition and improve their overall health.

It is important to note that a healthy and balanced diet should be tailored to an individual's age, gender, body size, activity level, and any underlying medical conditions. Consulting with a healthcare professional, such as a registered dietitian or nutritionist, can help ensure that an individual's dietary needs are being met in a safe and effective way.

Coumestrol is a type of phytoestrogen, which is a plant-derived compound that can mimic the effects of estrogen in the body. It belongs to a class of compounds called coumestans and is found in various plants such as clover, alfalfa, and soybeans. Coumestrol has weak estrogenic activity and can bind to estrogen receptors in the body, potentially affecting hormonal balance and having both estrogenic and anti-estrogenic effects. It has been studied for its potential effects on various health conditions, including cancer, osteoporosis, and cardiovascular disease.

Postmenopause is a stage in a woman's life that follows 12 months after her last menstrual period (menopause) has occurred. During this stage, the ovaries no longer release eggs and produce lower levels of estrogen and progesterone hormones. The reduced levels of these hormones can lead to various physical changes and symptoms, such as hot flashes, vaginal dryness, and mood changes. Postmenopause is also associated with an increased risk of certain health conditions, including osteoporosis and heart disease. It's important for women in postmenopause to maintain a healthy lifestyle, including regular exercise, a balanced diet, and routine medical check-ups to monitor their overall health and manage any potential risks.

Lignans are a type of plant compound that have antioxidant and estrogen properties. They are found in various plants such as seeds, grains, fruits, and vegetables. Once consumed, some lignans can be converted by intestinal bacteria into enterolactone and enterodiol, which can have weak estrogenic or anti-estrogenic effects in the body. These compounds have been studied for their potential health benefits, including reducing the risk of cancer and heart disease. However, more research is needed to fully understand their effects and potential health benefits.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

A dietary supplement is a product that contains nutrients, such as vitamins, minerals, amino acids, herbs or other botanicals, and is intended to be taken by mouth, to supplement the diet. Dietary supplements can include a wide range of products, such as vitamin and mineral supplements, herbal supplements, and sports nutrition products.

Dietary supplements are not intended to treat, diagnose, cure, or alleviate the effects of diseases. They are intended to be used as a way to add extra nutrients to the diet or to support specific health functions. It is important to note that dietary supplements are not subject to the same rigorous testing and regulations as drugs, so it is important to choose products carefully and consult with a healthcare provider if you have any questions or concerns about using them.

Vegetable proteins, also known as plant-based proteins, are nitrogenous organic compounds derived from plants. These proteins are composed of amino acid chains that are essential for the growth, repair, and maintenance of body tissues. Vegetable proteins can be found in a wide variety of plant sources such as legumes (e.g., beans, lentils, peas), grains (e.g., rice, wheat, corn), nuts, seeds, and vegetables.

It is important to note that while vegetable proteins are often considered "incomplete" because they may lack one or more of the essential amino acids found in animal-based proteins, consuming a variety of plant-based protein sources throughout the day can provide all the necessary amino acids for a healthy diet. Vegetarian and vegan diets that are well-planned can meet protein needs without the use of animal products.

Biological availability is a term used in pharmacology and toxicology that refers to the degree and rate at which a drug or other substance is absorbed into the bloodstream and becomes available at the site of action in the body. It is a measure of the amount of the substance that reaches the systemic circulation unchanged, after administration by any route (such as oral, intravenous, etc.).

The biological availability (F) of a drug can be calculated using the area under the curve (AUC) of the plasma concentration-time profile after extravascular and intravenous dosing, according to the following formula:

F = (AUCex/AUCiv) x (Doseiv/Doseex)

where AUCex is the AUC after extravascular dosing, AUCiv is the AUC after intravenous dosing, Doseiv is the intravenous dose, and Doseex is the extravascular dose.

Biological availability is an important consideration in drug development and therapy, as it can affect the drug's efficacy, safety, and dosage regimen. Drugs with low biological availability may require higher doses to achieve the desired therapeutic effect, while drugs with high biological availability may have a more rapid onset of action and require lower doses to avoid toxicity.

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

Anticarcinogenic agents are substances that prevent, inhibit or reduce the development of cancer. They can be natural or synthetic compounds that interfere with the process of carcinogenesis at various stages, such as initiation, promotion, and progression. Anticarcinogenic agents may work by preventing DNA damage, promoting DNA repair, reducing inflammation, inhibiting cell proliferation, inducing apoptosis (programmed cell death), or modulating immune responses.

Examples of anticarcinogenic agents include chemopreventive agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and retinoids; phytochemicals found in fruits, vegetables, and other plant-based foods; and medications used to treat cancer, such as chemotherapy, radiation therapy, and targeted therapies.

It is important to note that while some anticarcinogenic agents have been shown to be effective in preventing or reducing the risk of certain types of cancer, they may also have potential side effects and risks. Therefore, it is essential to consult with a healthcare professional before using any anticarcinogenic agent for cancer prevention or treatment purposes.

A cross-over study is a type of experimental design in which participants receive two or more interventions in a specific order. After a washout period, each participant receives the opposite intervention(s). The primary advantage of this design is that it controls for individual variability by allowing each participant to act as their own control.

In medical research, cross-over studies are often used to compare the efficacy or safety of two treatments. For example, a researcher might conduct a cross-over study to compare the effectiveness of two different medications for treating high blood pressure. Half of the participants would be randomly assigned to receive one medication first and then switch to the other medication after a washout period. The other half of the participants would receive the opposite order of treatments.

Cross-over studies can provide valuable insights into the relative merits of different interventions, but they also have some limitations. For example, they may not be suitable for studying conditions that are chronic or irreversible, as it may not be possible to completely reverse the effects of the first intervention before administering the second one. Additionally, carryover effects from the first intervention can confound the results if they persist into the second treatment period.

Overall, cross-over studies are a useful tool in medical research when used appropriately and with careful consideration of their limitations.

The double-blind method is a study design commonly used in research, including clinical trials, to minimize bias and ensure the objectivity of results. In this approach, both the participants and the researchers are unaware of which group the participants are assigned to, whether it be the experimental group or the control group. This means that neither the participants nor the researchers know who is receiving a particular treatment or placebo, thus reducing the potential for bias in the evaluation of outcomes. The assignment of participants to groups is typically done by a third party not involved in the study, and the codes are only revealed after all data have been collected and analyzed.

Premenopause is not a formal medical term, but it's often informally used to refer to the time period in a woman's life leading up to menopause. During this stage, which can last for several years, hormonal changes begin to occur in preparation for menopause. The ovaries start to produce less estrogen and progesterone, which can lead to various symptoms such as irregular periods, hot flashes, mood swings, and sleep disturbances. However, it's important to note that not all women will experience these symptoms.

The official medical term for the stage when a woman's period becomes irregular and less frequent, but hasn't stopped completely, is perimenopause. This stage typically lasts from two to eight years and ends with menopause, which is defined as the point when a woman has not had a period for 12 consecutive months. After menopause, women enter postmenopause.

Flavonoids are a type of plant compounds with antioxidant properties that are beneficial to health. They are found in various fruits, vegetables, grains, and wine. Flavonoids have been studied for their potential to prevent chronic diseases such as heart disease and cancer due to their ability to reduce inflammation and oxidative stress.

There are several subclasses of flavonoids, including:

1. Flavanols: Found in tea, chocolate, grapes, and berries. They have been shown to improve blood flow and lower blood pressure.
2. Flavones: Found in parsley, celery, and citrus fruits. They have anti-inflammatory and antioxidant properties.
3. Flavanonols: Found in citrus fruits, onions, and tea. They have been shown to improve blood flow and reduce inflammation.
4. Isoflavones: Found in soybeans and legumes. They have estrogen-like effects and may help prevent hormone-related cancers.
5. Anthocyanidins: Found in berries, grapes, and other fruits. They have antioxidant properties and may help improve vision and memory.

It is important to note that while flavonoids have potential health benefits, they should not be used as a substitute for medical treatment or a healthy lifestyle. It is always best to consult with a healthcare professional before starting any new supplement regimen.

Pterocarpans are a type of chemical compound known as flavonoids, which are found naturally in plants. They are specifically classified as a subgroup of pterocarpanoids and have a characteristic chemical structure consisting of two benzene rings joined by a heterocyclic pyran ring.

Pterocarpans are produced through the phenylpropanoid pathway, which is a metabolic route used by plants to synthesize various compounds with diverse biological activities. These compounds have been found to possess a range of pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer effects.

Some examples of pterocarpans include medicarpin, maackiain, and glyceollins. They are commonly found in leguminous plants such as soybeans, kudzu, and red clover. In recent years, there has been growing interest in the potential therapeutic applications of pterocarpans due to their diverse biological activities.

Caseins are a group of phosphoproteins found in the milk of mammals, including cows and humans. They are the major proteins in milk, making up about 80% of the total protein content. Caseins are characterized by their ability to form micelles, or tiny particles, in milk when it is mixed with calcium. This property allows caseins to help transport calcium and other minerals throughout the body.

Caseins are also known for their nutritional value, as they provide essential amino acids and are easily digestible. They are often used as ingredients in infant formula and other food products. Additionally, caseins have been studied for their potential health benefits, such as reducing the risk of cardiovascular disease and improving bone health. However, more research is needed to confirm these potential benefits.

"Chromans" are a class of organic compounds that contain a benzene fused to a five-membered saturated carbon ring containing one oxygen atom. This particular ring structure is also known as a chromane. Chromans have various applications in the field of medicinal chemistry and pharmacology, with some derivatives exhibiting biological activities such as antioxidant, anti-inflammatory, and cardiovascular protective effects. Some well-known chroman derivatives include vitamin E (tocopherols and tocotrienols) and several synthetic drugs like chromanol, a calcium channel blocker used in the treatment of hypertension and angina pectoris.

Ovariectomy is a surgical procedure in which one or both ovaries are removed. It is also known as "ovary removal" or "oophorectomy." This procedure is often performed as a treatment for various medical conditions, including ovarian cancer, endometriosis, uterine fibroids, and pelvic pain. Ovariectomy can also be part of a larger surgical procedure called an hysterectomy, in which the uterus is also removed.

In some cases, an ovariectomy may be performed as a preventative measure for individuals at high risk of developing ovarian cancer. This is known as a prophylactic ovariectomy. After an ovariectomy, a person will no longer have menstrual periods and will be unable to become pregnant naturally. Hormone replacement therapy may be recommended in some cases to help manage symptoms associated with the loss of hormones produced by the ovaries.

High-performance liquid chromatography (HPLC) is a type of chromatography that separates and analyzes compounds based on their interactions with a stationary phase and a mobile phase under high pressure. The mobile phase, which can be a gas or liquid, carries the sample mixture through a column containing the stationary phase.

In HPLC, the mobile phase is a liquid, and it is pumped through the column at high pressures (up to several hundred atmospheres) to achieve faster separation times and better resolution than other types of liquid chromatography. The stationary phase can be a solid or a liquid supported on a solid, and it interacts differently with each component in the sample mixture, causing them to separate as they travel through the column.

HPLC is widely used in analytical chemistry, pharmaceuticals, biotechnology, and other fields to separate, identify, and quantify compounds present in complex mixtures. It can be used to analyze a wide range of substances, including drugs, hormones, vitamins, pigments, flavors, and pollutants. HPLC is also used in the preparation of pure samples for further study or use.

... is an isomer of flavone, which is chromone substituted with a phenyl group in the 2-position. In isoflavone, the ... Isoflavone differs from flavone (2-phenyl-4H-1-benzopyr-4-one) in location of the phenyl group. Isoflavones are produced via a ... Isoflavones have GRAS status in the United States. In a risk assessment of isoflavone supplements for post-menopausal women, ... Isoflavones are substituted derivatives of isoflavone, a type of naturally occurring isoflavonoids, many of which act as ...

https://en.wikipedia.org/wiki/Isoflavone

Luteone is a prenylated isoflavone, a type of flavonoid. It can be found in the pods of Laburnum anagyroides and can be ... Sato H.; Tahara S.; Ingham J. L.; Dziedzic S. Z. (1995). "Isoflavones from pods of Laburnum anagyroides". Phytochemistry. 39 (3 ... Isoflavones, Prenylflavonoids, Resorcinols, All stub articles, Aromatic compound stubs). ...

https://en.wikipedia.org/wiki/Luteone_(isoflavone)

Retusin is an O-methylated isoflavone, a type of flavonoid. It can be found in Fabaceae species like Dipteryx odorata, in ... Isoflavones from Dipteryx odorata. Teruo Hayashi and Ronald H. Thomson, Phytochemistry, Volume 13, Issue 9, September 1974, ... O-methylated isoflavones, Catechols, All stub articles, Aromatic compound stubs). ...

https://en.wikipedia.org/wiki/Retusin_(isoflavone)

In enzymology, an isoflavone 2'-hydroxylase (EC 1.14.14.90, Formerly EC 1.14.13.89) is an enzyme that catalyzes the chemical ... Akashi T, Aoki T, Ayabe S (1998). "CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2 ... The systematic name of this enzyme class is isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating). Other names in common ... H2O The 4 substrates of this enzyme are isoflavone, NADPH, H+, and O2, whereas its 3 products are 2'-hydroxyisoflavone, NADP+, ...

https://en.wikipedia.org/wiki/Isoflavone_2'-hydroxylase

In enzymology, an isoflavone 3'-hydroxylase (EC 1.14.14.88, Formerly EC 1.14.13.52) is an enzyme that catalyzes the chemical ... Hinderer W, Flentje U, Barz W (1987). "Microsomal isoflavone 2'-hydroxylases and 3'-hydroxylases from chickpea (Cicer arietinum ... This enzyme is also called isoflavone 3'-monooxygenase. This enzyme participates in isoflavonoid biosynthesis. It employs one ...

https://en.wikipedia.org/wiki/Isoflavone_3'-hydroxylase

In enzymology, a monoprenyl isoflavone epoxidase (EC 1.14.99.34) is an enzyme that catalyzes the chemical reaction 7-O- ... Other names in common use include monoprenyl isoflavone monooxygenase, and 7-O-methylluteone:O2 oxidoreductase. Tanaka M, ... Isoflavones metabolism, All stub articles, EC 1.14 stubs). ...

https://en.wikipedia.org/wiki/Monoprenyl_isoflavone_epoxidase

In enzymology, an isoflavone 7-O-methyltransferase (EC 2.1.1.150) is an enzyme that catalyzes the chemical reaction S-adenosyl- ... doi:10.1016/0031-9422(91)85107-B. He XZ, Dixon RA (2000). "Genetic manipulation of isoflavone 7-O-methyltransferase enhances ... cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase". Plant Mol. Biol. 36 (1): 43-54. ... Edwards R, Dixon RA (1991). "Isoflavone O-methyltransferase activities in elicitor-treated cell suspension cultures of Medicago ...

https://en.wikipedia.org/wiki/Isoflavone_7-O-methyltransferase

... an isoflavone 7-O-beta-D-glucoside Thus, the two substrates of this enzyme are UDP-glucose and isoflavone, whereas its two ... In enzymology, an isoflavone 7-O-glucosyltransferase (EC 2.4.1.170) is an enzyme that catalyzes the chemical reaction UDP- ... The systematic name of this enzyme class is UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase. Other names in common use ... Koster J, Barz W (1981). "UDP-glucose:isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.)". Arch. ...

https://en.wikipedia.org/wiki/Isoflavone_7-O-glucosyltransferase

Other names in common use include 4'-hydroxyisoflavone methyltransferase, isoflavone methyltransferase, and isoflavone O- ... In enzymology, an isoflavone 4'-O-methyltransferase (EC 2.1.1.46) is an enzyme that catalyzes the chemical reaction S-adenosyl- ... Wengenmayer H, Ebel J, Grisebach H (1974). "Purification and properties of a S-adenosylmethionine: isoflavone 4'-O- ... The systematic name of this enzyme class is S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase. ...

https://en.wikipedia.org/wiki/Isoflavone_4'-O-methyltransferase

In enzymology, an isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase (EC 2.3.1.115) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6"-O-malonyltransferase. Other names in ... Portal: Biology v t e (EC 2.3.1, Enzymes of unknown structure, Isoflavones metabolism, All stub articles, EC 2.3 stubs). ... Koester J, Bussmann R, Barz W (1984). "Malonyl-coenzyme A:isoflavone 7-O-glucoside-6"-O-malonyltransferase from roots of chick ...

https://en.wikipedia.org/wiki/Isoflavone-7-O-beta-glucoside_6"-O-malonyltransferase

... is an O-methylated isoflavone, a type of flavonoid. It has been isolated for the first time by Finnemore in 1910 in ... Sheikh, S.; Weiner, H. (1997). "Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin". ... "Isoflavones. III. The Structure of Prunetin and a New Synthesis of Genistein1". The Journal of Organic Chemistry. 10 (4): 288- ... O-methylated isoflavones, All stub articles, Aromatic compound stubs). ...

https://en.wikipedia.org/wiki/Prunetin

Soy contains isoflavones-polyphenolic compounds, produced by legumes including peanuts and chickpeas. Isoflavones are closely ... Qin Y, Niu K, Zeng Y, Liu P, Yi L, Zhang T, Zhang QY, Zhu JD, Mi MT (2013). "Isoflavones for hypercholesterolaemia in adults". ... Coumestrol, an isoflavone coumarin derivative, is the only coumestan in foods. Saponins, a class of natural surfactants (soaps ... Soy isoflavones-polyphenolic compounds that are also produced by other legumes like peanuts and chickpeas-are under preliminary ...

https://en.wikipedia.org/wiki/Soybean

Her research interests have included trans fatty acids; soy protein and isoflavones; sterol and stanol esters; modified ...

https://en.wikipedia.org/wiki/Alice_H._Lichtenstein

1970). "The homo-isoflavones II1). Isolation and structure of 4′-o-methyl-punctatin, autumnalin and 3,9-dihydro-autumnalin". ...

https://en.wikipedia.org/wiki/Homoisoflavonoid

Soy isoflavones are a group of compounds found in and isolated from the soybean. Of note, total isoflavones in soybeans are-in ... "Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes". Nature ... The isoflavone synthase (IFS) enzyme was suggested to be a P-450 oxygenase family, and this was confirmed by Shinichi Ayabe's ... Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs like kwao krua ( ...

https://en.wikipedia.org/wiki/Daidzein

The homo-isoflavones 4′-o-methyl-punctatin, autumnalin and 3,9-dihydro-autumnalin can be found in E. autumnalis. "POWO - E. ... 1970). "The homo-isoflavones II. Isolation and structure of 4′-o-methyl-punctatin, autumnalin and 3,9-dihydro-autumnalin". ...

https://en.wikipedia.org/wiki/Eucomis_autumnalis

Shawl, Abdul S.; Dar, Bashir A. (September 1985). "Isoflavones from Iris hookeriana". Journal of Natural Products. 48 (5): 849- ...

https://en.wikipedia.org/wiki/Iris_hookeriana

Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and ... Genistein and other isoflavones have been identified as angiogenesis inhibitors, and found to inhibit the uncontrolled cell ... Isoflavones can act like estrogen, stimulating development and maintenance of female characteristics, or they can block cells ... Isoflavones also produce non-hormonal effects.[citation needed] Genistein influences multiple biochemical functions in living ...

https://en.wikipedia.org/wiki/Genistein

Also isoflavones have been isolated from the rhizomes. It can also treat animal ailments.[citation needed] The plant can also ... In 2008, a chemical study was carried out on the rhizomes of Iris kashmiriana led to the isolation of three isoflavones ... In 1996, a study was carried out on the rhizomes of Iris kashmiriana, two new isoflavones, 'isocladrastin' and 'kashmigenin', ... In December 2012, an evaluation study was carried out on the isoflavones ('isonigricin' and 'isoirisolidone'), isolated from ...

https://en.wikipedia.org/wiki/Iris_kashmiriana

Several isoflavones (chemical compounds) were found. In December 1884, a further study was carried out on the rhizomes of Iris ... doi:10.1016/s0031-9422(00)80460-4. Agarwal, V.K.; Thappa, R.K.; S.G., Agarwal; Mehraa, M.S.; Dhar, K.L. (1984). "Isoflavones of ... milesii and Iris kemaonensis (under old spelling 'kumaonensis'). It found several isoflavones in both rhizomes. Tetrahydroxy-3 ...

https://en.wikipedia.org/wiki/Iris_milesii

O-methylated isoflavones, Isoflavone glucosides, Hydroxymethyl compounds, All stub articles, Aromatic compound stubs). ... Iridin is an isoflavone, a type of flavonoid. It is the 7-glucoside of irigenin and can be isolated from several species of ... "Isoflavones of two Iris species". Phytochemistry. 23 (11): 2703-2704. doi:10.1016/S0031-9422(00)84141-2. J. B. Harborne The ...

https://en.wikipedia.org/wiki/Iridin

In December 2002, a chemical study carried out on the rhizomes of Iris kemaonensis found several isoflavones, including ... "Isoflavones of two Iris species". Phytochemistry. 23 (11): 2703-2704. doi:10.1016/S0031-9422(00)84141-2. J. B. Harborne The ... It found several isoflavones in both rhizomes. Including 'iriskumaonin' methyl ether, iriskumaonin (C18H24O7,), irisflorentin, ...

https://en.wikipedia.org/wiki/Iris_kemaonensis

In 2004, a study of Iris songarica found the presence of 2 isoflavones, Irilin A and Irisone B which were isolated from the ... Ayatollahi, Seydabdul Majid; Moein, Mahmood Reza; Kobarfard, Farzad; Choudhary, Muhmmad Iqbal (2004). "Two Isoflavones From ...

https://en.wikipedia.org/wiki/Iris_songarica

... produces chitosanase and isoflavones . Jiang, Xiayun; Chen, Daochun; Chen, Liehuan; Yang, Guoning; Zou, ...

https://en.wikipedia.org/wiki/Streptomyces_roseolus

2013). Isoflavones chemistry, analysis, function and effects. Cambridge, U.K.: Royal Society of Chemistry. pp. 518-526. ISBN ... In any case, coumestrol has estrogenic activity that is 30 to 100 times greater than that of isoflavones. The chemical shape of ... "USDA-Iowa State University Database on the Isoflavone Content of Foods" (PDF). Retrieved 10 March 2022. Shaw, Ian (March 2009 ... Bhagwat, Seema; Haytowitz, David; Holden, Joanne (September 2008). USDA Database for the Isoflavone Content of Selected Foods ( ...

https://en.wikipedia.org/wiki/Coumestrol

The isoflavone prunetin was isolated for the first time by Finnemore in 1910 from the bark of P. emarginata. The Plant List, ... ISBN 0-9665463-1-8 Isoflavones. III. The structure of prunetin and a new synthesis of genistein. R. L. Shriner, C. J. Hull, J. ...

https://en.wikipedia.org/wiki/Prunus_emarginata

Isoflavones like barbigerone, genistin and a chromone 6,7-dimethoxy-2,3-dihydrochromone were identified. The isoflavone ... Barbigerone Wangensteen H; Alamgir M; Rajia S; Samuelsen AB; Malterud KE (2005). "Rotenoids and isoflavones from Sarcolobus ... a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway". Cell Physiol ... isoflavones and phenolic glycosides from Sarcolobus globosus". Fitoterapia. 77 (4): 290-295. doi:10.1016/j.fitote.2006.03.017. ...

https://en.wikipedia.org/wiki/Sarcolobus_globosus

... is one of a few pyranoisoflavones among several groups of isoflavones. It was first isolated from the seed of a ... doi:10.1016/0031-9422(90)85212-X. Yenesew, Abiy; Midiwo, Jacob O.; Waterman, Peter G. (1998). "Rotenoids, isoflavones and ... Wangensteen, H; Alamgir, M; Rajia, S; Samuelsen, AB; Malterud, KE (2005). "Rotenoids and isoflavones from Sarcolobus globosus ... Dagne E, Bekele A (1990). "C-prenylated isoflavones from Millettia ferruginea". Phytochemistry. 29 (8): 2679-2682. ...

https://en.wikipedia.org/wiki/Barbigerone

... s are related to the isoflavones. Many plants in the subfamily Faboideae contain rotenoids. Rotenoids can be found in ...

https://en.wikipedia.org/wiki/Rotenoid

"Isoflavones and flavonols from Andira humilis". Biochemical Systematics and Ecology. 38 (6): 1242-1245. doi:10.1016/j.bse. ...

https://en.wikipedia.org/wiki/Andira_humilis

Isoflavone is an isomer of flavone, which is chromone substituted with a phenyl group in the 2-position. In isoflavone, the ... Isoflavone differs from flavone (2-phenyl-4H-1-benzopyr-4-one) in location of the phenyl group. Isoflavones are produced via a ... Isoflavones have GRAS status in the United States. In a risk assessment of isoflavone supplements for post-menopausal women, ... Isoflavones are substituted derivatives of isoflavone, a type of naturally occurring isoflavonoids, many of which act as ...

https://en.wikipedia.org/wiki/Isoflavone

Isoflavones from soy, despite having weak oestrogenic activity, do not adversely affect blood clotting function, says a new ... Related tags Postmenopausal women Isoflavones Coagulation Isoflavones from soy, despite having weak oestrogenic activity, do ... Study backs isoflavones safety rep for blood clotting. By Stephen Daniells 12-Dec-2007. - Last updated on 19-Jul-2008 at 15:00 ... Isoflavones from soy have been shown to provide a number of health benefits, including the promotion of heart health and the ...

https://www.nutraingredients.com/Article/2007/12/12/Study-backs-isoflavones-safety-rep-for-blood-clotting

Isoflavones Market Size Research Report, identifies new revenue opportunity in pharmaceuticals and food & beverages segments. ... 4.2 Isoflavones Market, By Region 4.3 Isoflavones Market, By Application 4.4 Asia Pacific: Isoflavones Market, By Source and ... Table 6 Soy Isoflavones Market Size, By Region, 2017 2025 (USD Million). Table 7 Soy Isoflavones Market Size, By Region, 2017 ... Table 10 Other Isoflavones Market Size, By Region, 2017 2025 (USD Million). Table 11 Other Isoflavones Market Size, By Region, ...

https://www.marketsandmarkets.com/Market-Reports/isoflavones-market-161667005.html

Soy Isoflavones - If youre looking for probiotics, fibers, omega 3s or a variety of other nutraceuticals, this category ...

https://www.nutraceuticalsworld.com/buyersguide/C_US/S_NJ/specialty-ingredients/soy-isoflavones/

Isoflavones from Neuroscience News features breaking science news from research labs, scientists and colleges around the world. ... A diet rich in foods containing isoflavone, a plant-based compound found in legumes, chickpeas, and peanuts, that resembles ...

https://neurosciencenews.com/neuroscience-terms/isoflavones/

Barnes sought to identify the isoflavones and their mechanisms of action that inhibit breast cancer development. Isoflavones ...

https://www.aicr.org/research/projects/effects-of-isoflavones-on-human-breast-cancer-cells-in-culture/

Discover the health benefits of Non-GMO Soy Isoflavones 750 mg and more Soy Isoflavones. ... Non-GMO Soy Isoflavones 750 mg at discount prices! ... Soy Isoflavones: Isoflavone Rx-Phytoestrogen Soy.... Isoflavone ... Non-GMO Soy Isoflavones 750 mg 60 Capsules. Buy Non-GMO Soy Isoflavones 750 mg 60 Rapid Release Capsules & other Soy ... Soy Isoflavones Supplements. Puritan.com - Soy Isoflavones - Soy is best known for its ability to help with menopause.* ...

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Sojar Plus-Calcio information about active ingredients, pharmaceutical forms and doses by Sojar, Sojar Plus-Calcio indications, usages and related health products lists

https://drugs-about.com/drugs-s/sojar-plus-calcio.html

The soy Isoflavones is produced from the leaf, bark, seed, and shell of soy plant and the end... ... EMAILWIRE.COM, October 18, 2018 ) Overview The soy Isoflavones is potentially a very rich source of estrogen and vitamin E and ... The soy Isoflavones is produced from the leaf, bark, seed, and shell of soy plant and the end products of Soy Isoflavones can ... Isoflavones are phytoestrogens have a similar chemical structure to the hormone estrogen. Isoflavones may have estrogens or ...

http://www.emailwire.com/release/943247-Soy-Isoflavones-Market-Segmented-By-Application-2023.html

To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, ... a metabolite of isoflavone, has a preventive effect on prostate cancer. ... To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, ... Our previous case-control study suggested that equol, a metabolite of isoflavone, has a preventive effect on prostate cancer. ...

https://pubmed.ncbi.nlm.nih.gov/21988617/?dopt=Abstract

The most common type of breast cancer is estrogen-dependent, and the anti-estrogenic effects of isoflavones are known. The ... The unpleasant odor of soy milk and the absorption efficiency for isoflavones can be improved using a recently developed ... an epidemiological study examining the incidence of breast cancer and soy isoflavone consumption, and a non-clinical study ... On the other hand, the isoflavones in soy milk also undergo structural changes during bacterial fermentation. Most isoflavones ...

https://www.mdpi.com/1422-0067/16/5/10907

Isoflavones have a similar chemical structure to the hormone estrogen. Isoflavones are not a substitute for estrogen, as they ... The only way to know what isoflavones do is to study isoflavones ... Soy Isoflavones and Estrogen. By Ginny Messina,2011-08-04T11:48 ... Im taking Soy Isoflavones tablets to treat hot flashes and night sweats. It did worked like magic for the first month of usage ... In fact, if isoflavones were the same as estrogen, there wouldnt really be any interest in studying them as alternatives to ...

https://www.theveganrd.com/2011/08/soy-isoflavones-and-estrogen

Download the citation for this article by clicking on one of the following citation managers:. ...

https://ebm.bmj.com/content/19/5/178.citation-tools

Consumption of foods containing 110 mg/d of soy isoflavone aglycone equivalents for 1 y did not prevent postmenopausal bone ... Consumption of isoflavone-enriched products resulted in increased isoflavone concentrations in plasma and urine, whereas ... consumed isoflavone-enriched foods providing a mean daily intake of 110 mg isoflavone aglycones or control products for 1 y ... Results: Consumption of isoflavone-enriched products did not alter bone mineral density of the lumbar spine and total body or ...

https://pubmed.ncbi.nlm.nih.gov/18326616/

Soy Isoflavone Alleviates A 1-42-Induced Impairment of Learning and Memory Ability through the Regulation of RAGE/LRP-1 in ... Neuronal and Vascular Tissue http://www.chiro.org/Graphics_Box_NUTRITION/ABSTRACTS/Soy_Isoflavone_Alleviates_AB1-42.shtml ... Soy Isoflavone Alleviates A 1-42-Induced. Impairment of Learning and Memory Ability through the Regulation of RAGE/LRP-1 in ... These results suggested that soy isoflavone (SIF) could protect A -impaired learning and memory in rats, and its mechanism ...

https://chiro.org/Graphics_Box_NUTRITION/ABSTRACTS/Soy_Isoflavone_Alleviates_AB1-42.shtml

The isoflavones genistin and daidzin are able to balance estrogen deficiencies. In the cosmetic field they are used for the ... Isoflavones stimulate the collagen synthesis as well as the cell formation and slow down the collagen degradation process. The ... Boswellia nanoparticles Butcher´s Broom serum Plus Coenzyme Q10 nanoparticles Evening primrose oil nanoparticles Isoflavone ...

https://dermaviduals.de/english/productlistings/dermaviduals-modular/active-agent-concentrates/nanoparticles/isoflavone-serum.html

Isoflavones. J Med Chem 2010 Aug 26;53(16):6153-63 isoangustone A 0 *Isoflavones. J Sep Sci 2010 Mar;33(4-5):664-71 vogliiol 0 ... Isoflavones. Adv Exp Med Biol. 2010;664():585-91 sedacin B 0 *Isoflavones. Fitoterapia. 2011 Apr;82(3):405-7 sedacin A 0 * ... Isoflavones. J Nat Prod. 2005 Mar;68(3):361-4. licoriquinone A 0 *Isoflavones *Quinones. J Nat Prod. 2011 Dec 27;74(12):2514-9 ... Isoflavones. Fitoterapia. 2009 Oct;80(7):394-8 ledebourin C 0 *Isoflavones. Fitoterapia. 2009 Oct;80(7):394-8 more... To share ...

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Global Isoflavones Market By Form (Powder and liquid), By Application (Pharmaceuticals, Nutraceuticals, Cosmetics and Food & ... Chapter 6. Global Isoflavones Market by Region. 6.1 North America Isoflavones Market. 6.1.1 North America Isoflavones Market by ... 6.1.4.1 US Isoflavones Market. 6.1.4.1.1 US Isoflavones Market by Form. 6.1.4.1.2 US Isoflavones Market by Application. 6.1.4.1 ... 6.2.4.2 UK Isoflavones Market. 6.2.4.2.1 UK Isoflavones Market by Form. 6.2.4.2.2 UK Isoflavones Market by Application. 6.2.4.2 ...

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Results in animals suggest favourable coronary vasomotor actions of isoflavones; however, the effects of isoflavones on the ... Serum concentrations of the isoflavones genistein, daidzein and equol were increased by active treatment (P,0.001, P,0.001 and ... Seventy-one subjects were randomized, double-blind, to isoflavone-intact soya protein [active; n=33, aged 58±8 years (mean±S.D ... Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk ...

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Soy isoflavones are reported to augment the direct effect of radiation therapy on prostate cancer cells while limiting damage ... Consumption of Soy Isoflavone Enriched Bread in Men with Prostate Cancer Is Associated with Reduced Proinflammatory Cytokines ... A novel soy bread formulation was developed that delivers 34-mg total soy isoflavones per 50-g slice. Two slices of this bread ... Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with ...

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The researchers attribute the effect to isoflavones, a natural compound in soybeans. ... "We did not know whether there was a direct effect of isoflavones on the immune system or whether it was a result of isoflavones ... Isoflavones in soybean help protect pigs against viral infections. URBANA, Ill. -- Pigs that eat soybean as a regular part of ... While isoflavones have a wide variety of anti-inflammatory and anti-oxidative cell activities, they also have estrogen-like ...

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We relied only on studies assessing the effects of isoflavones contained in soy protein or on the isoflavones alone. Yang et al ... The studies conducted with soy dietary isoflavones and isoflavone alone in cell culture or in animal models and human studies ... Moreover, the ability of both extracted isoflavone and soy protein with isoflavones to modulate the lipid profile suggests ... In addition, the structural similarity between soy isoflavones and endogenous 17-β-estradiol suggests that isoflavones, by ...

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Posts about soy isoflavones written by Deb Headworth ... Tag Archives: soy isoflavones Hormones increase frequency of ... Posted by Deb Headworth in black cohash, flaxseed, GLA, hormonal balance, hormones, menstration, MIGRAINES, soy isoflavones, ... Natural help to balance hormones - black cohash, soy isoflavones, flaxseed lignans. GLA ...

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... isoflavone metabolism, soy isoflavones, phytoestrogens, genistein, daidzein, equol, puerarin, isoflavone glycosides, synthesis ... Keywords: Isoflavones, secondary metabolites, natural products, plant polyphenolics, flavonoids, isoflavone biosynthesis, ... Plant Isoflavones, their Impact on Life Sciences, Medicine and Industry. Author(s): *Pharmaceutical Research Institute, 01-793 ... The presence of isoflavones in food products, which are derived from processing of soybean are generally considerd safe and ...

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the major isoflavones in soybean are genistein and daidzein. (wikipedia.org)
Similarly, another intermediate naringenin chalcone is converted to the isoflavone daidzein by sequential action of three legume-specific enzymes: chalcone reductase, type II chalcone isomerase, and isoflavone synthase. (wikipedia.org)
The supplements were provided by Acatris (SoyLife) and contained 7.05 per cent isoflavones in the following concentrations: 52 per cent daidzein, 33 per cent glycitein, and 15 per cent genistein. (nutraingredients-usa.com)
Analysis of the soybean extract using HPLC, UV-VIS spectrophotometry, and LC-MS led to identification of the isoflavones genistein and daidzein as major components by direct comparison with authentic standard reference isoflavones. (nih.gov)
The IC50 values for inhibition of TPO-catalyzed reactions by genistein and daidzein were ca. 1-10 microM, concentrations that approach the total isoflavone levels (ca. 1 microM) previously measured in plasma from humans consuming soy products. (nih.gov)
The judge approved a series of menopausal and pre-menstrual treatment indications related to products containing between 20mg and 200mg of the isoflavones forms, genistein and daidzein. (nutraingredients.com)
Soy contains genistein and daidzein isoflavones. (nih.gov)
The most abundant active components of isoflavones are genistein and daidzein. (biomedcentral.com)
The two major soy isoflavones are called genistein and daidzein. (web.app)
Soy contains many individual isoflavones, but the most beneficial are genistein and daidzein. (web.app)
Supports bone health: natrol soy Isoflavones supports bone health and contains at least 35% of Daidzein complemented with Genistein and Glycitein. (inosoc.com)
The main active components of soy isoflavones are daidzein, genistein and glycitein. (nutriadvanced.ie)
In particular, some bacteria can convert the isoflavone daidzein into equol, which has even greater oestrogenic activity than daidzein. (nutriadvanced.ie)
Genistein is one of the three major soybean isoflavones, along with daidzein and glycitein. (efloorball.net)
Soy supplements may reduce the risk of cardiovascular risk for people able to produce equol, a microbial-derived metabolite of the isoflavone daidzein, but equol supplements themselves may not have the same effects, says a new study. (nutraingredients-usa.com)

Soy milk has a much higher concentration of isoflavones than soy sauce, but fermented soybeans show considerably higher concentrations, with tempeh having the highest isoflavone content. (wikipedia.org)
Isoflavones are found in soybeans, chick peas and other legumes. (diagnose-me.com)
The highest amounts of isoflavones and soy protein are found in tempeh, whole soybeans (such as edamame), textured soy protein, soy nuts, tofu and soy milk. (diagnose-me.com)
Isoflavones, a type of phytochemical found in soybeans, chickpeas, legumes and clovers, can improve artery function in stroke patients, say researchers from Hong Kong. (lesliebeck.com)
Sök Soy Isoflavones omdömen, biverkningar, kuponger och mer från Foods made from SOYBEANS. (web.app)
2018-06-19 FOOD COMPOSITION AND ADDITIVES Determination of Isoflavones in Ready-to-Feed Soy-Based Infant Formula PAUL JOHNS,LOBAT DOWLATI, and WAYNE WARGO Abbott … Se hela listan på lpi.oregonstate.edu Isoflavones are found in soybeans, chick peas and other legumes. (web.app)
Isoflavones are found in: Soybeans Chickpeas Fava beans Pistachios Peanuts Other fruits and nuts Soy isoflavones are naturaly present in the soy bean. (web.app)
The soy protein isolate used to make formula has reduced levels of isoflavones compared with soybeans and soy flour, but higher levels than fermented products like tofu (Anderson and Wolf, 1995). (web.app)
Isoflavones are naturally occurring compounds found in soybeans. (nih.gov)
Soybeans contain plant-based substances called isoflavones. (medlineplus.gov)

Although isoflavones and closely related phytoestrogens are sold as dietary supplements, there is little scientific evidence for either the safety of long-term supplementation or of health benefits from these compounds. (wikipedia.org)
Isoflavones are produced via a branch of the general phenylpropanoid pathway that produces flavonoid compounds in higher plants. (wikipedia.org)
Plants use isoflavones and their derivatives as phytoalexin compounds to ward off disease-causing pathogenic fungi and other microbes. (wikipedia.org)
After this process, isoflavones are in the form of aglycones, which are smaller and assimilable lipophilic compounds. (botanical-online.com)
It seems that the usual consumption of soy increases the activity of beta-glucosidases enzymes responsible for converting isoflavones glycosides into aglycones (active compounds). (botanical-online.com)
Abstract: DESCRIPTION (provided by applicant): Soy protein rich in isoflavones (estrogen-like compounds) has been shown to prevent bone loss in ovariectomized rats. (nih.gov)
Isoflavones are a class of phytochemicals , which are compounds found only in plants. (diagnose-me.com)
The best way to consume isoflavones is in food form, so that you can benefit from all of soy's nutrients and beneficial compounds. (diagnose-me.com)
Besides the specially formulated multivitamin tablet, we've added a combination of sage extract, flaxseed lignans and soy isoflavones, compounds known as plant oestrogens. (healthspan.co.uk)
Isoflavones are compounds that have attracted attention as they can bind to human estrogen receptors (hERα) and are found in plants. (cam.ac.uk)
Soy and its bioactive compounds, isoflavones, have become a hot issue in the last 20 years. (web.app)
Nevertheless, the cross-consumption of foreign products is not safe for certain ethnic groups and requires risk assessment evaluation because of ethnic differences among populations that induce, for certain compounds Andrew Lessman discusses Soy Isoflavones. (web.app)
One of the benefits of soybean seed is that it contains secondary natural metabolite compounds, including phenolic acid, lignin, and isoflavones. (scirp.org)

Planetary Herbals Soy Genistein Isoflavone Powder is rich in isoflavones. (herbsdirect.com)

Use of soy isoflavone dietary supplements may be associated with reduction of hot flashes in postmenopausal women. (wikipedia.org)
Previous studies have reported conflicting results concerning soy isoflavones (40 to 99 mg/d doses) and bone health for postmenopausal women. (nutraingredients-usa.com)
Mathern said that more studies were ongoing to investigate the effects of either soy or isoflavones on bone density in humans, including the Osteoporosis Prevention Using Soy (OPUS) study - a multi-site, two-year research study on the use of soy isoflavones to prevent bone loss in 400 postmenopausal women. (nutraingredients-usa.com)
Our objective is to determine the three-year efficacy of isoflavone-rich soy extract in attenuating bone loss in postmenopausal women. (nih.gov)
The central hypothesis is that soy isoflavones will attenuate bone loss in early postmenopausal women by maintaining bone formation, being modulated by growth factors and isoflavone metabolism. (nih.gov)
This randomized double-blind placebo controlled clinical trial will examine the effects of two doses (80 or 120 mg/d) of isoflavone-rich soy extract on bone in non-osteoporotic early postmenopausal women (N=234). (nih.gov)
This study will provide valuable data on whether isoflavones impact bone in early postmenopausal women and help elucidate potential mechanisms, thereby contributing to our understanding of isoflavones as an alternative to traditional hormone therapy. (nih.gov)
2007). A review of clinical trials of soy isoflavones suggests some skeletal benefits in younger postmenopausal women (Messina et al. (web.app)
Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women. (nutriadvanced.ie)
Building on lessons learned from earlier studies, Iowa State University's D. Lee Alekel, Ph.D., and her colleagues at the USDA Agricultural Research Service's Western Human Nutrition Research Center, conducted the Soy Isoflavones for Reducing Bone Loss (SIRBL) Study, enrolling more than 250 healthy postmenopausal women in this multi-center trial. (nih.gov)
The soy isoflavones for reducing bone loss (SIRBL) study: a 3-year randomized controlled trial in postmenopausal women. (nih.gov)

An isoflavone derivative that has aroused much interest is equol, a substance related to breast cancer prevention. (botanical-online.com)
It has been observed that a certain type of intestinal microbiota is capable of producing equol from isoflavone daizdein . (botanical-online.com)
For example, there are currently investigations aimed at finding probiotics that perform this process of transforming isoflavones into derivatives such as equol to increase the possible effect of these substances. (botanical-online.com)
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. (nutriadvanced.ie)
Soy Isoflavones also facilitate Equol production. (hairloss-research.org)
Studies have shown that the sole inclusion of dietary soy or Isoflavones will eventually after several months, turn genetic Equol non-producers into Equol producers. (hairloss-research.org)
Equol production can be rapidly facilitated in genetic non-producers by combining Soy Isoflavones, Green Tea Extract, Sea Vegetables and Pro-biotics, in particular Bacillus Coagulans. (hairloss-research.org)

Individuals with sensitivities to soy should use isoflavones sourced from Soy Isoflavones - 100 Capsules · Related Items · Description · Ingredients · Dosage · Precautions · Dietary Needs · Ratings and Reviews. (web.app)
Fito 40 Capsules with isoflavones from soy and vitamin B6 for the regulation of hormonal activity an efficient nutritional supplement manufactured in Switzerland for Vivasan. (vivasan.club)
Capsules with isoflavones from soy (not genetically modified) and vitamin B6 which contributes to the regulation of hormonal activity. (vivasan.club)

In plant tissue, they most often occur as glycosides or their respective malonates or acetyl conjugates, rendering them even more water-soluble (see isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase). (wikipedia.org)
Soy isoflavones are found in the food in the form of glycosides . (botanical-online.com)
Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta-glucosidase. (nih.gov)
Beta-glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. (nih.gov)
1. Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica. (nih.gov)
4. New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt. (nih.gov)

Isoflavones are substituted derivatives of isoflavone, a type of naturally occurring isoflavonoids, many of which act as phytoestrogens in mammals. (wikipedia.org)
Soy isoflavones are plant substances that in the body have functions similar to the body's estrogen hormones, which is why they are also known as phytoestrogens . (botanical-online.com)
Soy isoflavones are well known phytoestrogens - active substances derived from plants that have a weak estrogen-like action. (foodnavigator.com)
Isoflavones are phytoestrogens, with a similarity in structure to human 17-β estradiol hormone. (nih.gov)
Isoflavones have a close similarity in structure to estrogens and are known as phytoestrogens [ 1 - 3 ]. (biomedcentral.com)
The isoflavones found in soy and red clover are examples of phytoestrogens. (nih.gov)

GNC #ad - 3 month supply: 50mg of Soy Isoflavone Concentrate packed into one convenient capsule. (inosoc.com)

This study is part of an emerging body of evidence that refutes a bone-sparing effect of soy isoflavone tablets. (nih.gov)
A double-blind, placebo-controlled trial was conducted to clinically evaluate the effect of soy isoflavone aglycone on the aged skin of middle-aged women. (hairloss-research.org)

Other dietary sources of isoflavones include chick pea (biochanin A), alfalfa (formononetin), and peanut (genistein). (wikipedia.org)
Current findings suggest that eating soy foods - natural sources of isoflavones - can protect and enhance our overall health. (diagnose-me.com)

The consumption of isoflavones-rich food or dietary supplements is under preliminary research for its potential association with lower rates of postmenopausal cancer and osteoporosis in women. (wikipedia.org)
Despite the frequent use of isoflavone supplements, there are insufficient data on safety and adverse effects. (wikipedia.org)
In a risk assessment of isoflavone supplements for post-menopausal women, the European Food Safety Authority found no adverse effects with intakes up to 150 mg/d, although it criticized the lack of data. (wikipedia.org)
A daily supplement of soy isoflavones reduced bone loss in early post-menopausal women - says a study from China that has been welcomed by the company who provided the supplements. (nutraingredients-usa.com)
But the new study adds to the debate by reporting that high dose soy isoflavone supplements (126 mg/d) did improve bone density, with no severe adverse effects. (nutraingredients-usa.com)
The women were randomly assigned to one of three groups and received daily soy supplements giving daily isoflavone doses of zero (placebo), 84 milligrams, or 126 milligrams. (nutraingredients-usa.com)
In supplements with isoflavones they are in the form of aglycones, are very concentrated, and are more bioavailable because there is no fiber or nutrients that can interfere with their absorption. (botanical-online.com)
As mentioned, these absorption differences would not occur in the case of isoflavone supplements in the form of aglycones or in fermented soy products. (botanical-online.com)
People with Type 2 , a condition that raises heart disease and stroke risk, saw no change in blood flow when taking isoflavone supplements. (lesliebeck.com)
This report describes the first attack of migraine with visual aura in a 57-year-old man who had introduced soy isoflavone supplements into his diet 9 months earlier. (neurology.org)

Isoflavones from soy have been shown to provide a number of health benefits, including the promotion of heart health and the maintenance of bone health in post-menopausal women. (nutraingredients.com)
We performed a systematic review of the literature in order to determine whether the amount of soy and isoflavones consumed has a positive effect in pre- and post-menopausal women. (nih.gov)

4) Ascertain the safety of isoflavone-rich soy extract. (nih.gov)
Another study found that consuming one capsule tid of a soy extract totaling 100mg of soy isoflavones per day effectively alleviated vasomotor symptoms, such as hot flashes associated with menopause, over a 4-month period compared with a placebo. (diagnose-me.com)
The mechanisms by which Soy Isoflavone Extract impacts Androgenetic Hair Loss are well established. (hairloss-research.org)

The study adds to a small but growing body of data supporting the role of isoflavones in respiratory health. (nutraingredients.com)

Whole soy foods like tofu and soy milk contain protective substances called isoflavones. (pcrm.org)

Highly processed foods made from legumes, such as tofu, retain most of their isoflavone content, and fermented miso, which has increased levels. (wikipedia.org)

Validation study of soya intake and plasma isoflavone levels among British women. (ox.ac.uk)

Isoflavones work together with soy protein in fighting disease. (diagnose-me.com)
Studies show that isoflavones account for approximately three-fourths of soy's protection, while its protein is responsible for about one-fourth. (diagnose-me.com)
Soy isoflavones and soy protein appear to have different actions in the body based on the following factors: Type of study. (web.app)
This study was designed to assess the independent effect of soy relative to animal protein and soy-derived isoflavones on circulating estrogen and androgen Pris: 87 kr. (web.app)
METHODS: Adult female cynomolgus monkeys (Macaca fascicularis) were assigned randomly to one of two diets containing saturated fat and cholesterol, differing only by protein source: (1) casein-lactalbumin (n = 29) or (2) soy protein with isoflavones (n = 32). (nih.gov)
ER beta from the prostate has a high affinity for genistein, a major soy isoflavone, which has several biological effects including a protein tyrosine kinase (PTK) inhibitor, an antioxidant, an inhibitor of angiogenesis, a blocker of topoisomerase II, an arrester of the cell cycle at the G2/M stage as well as acting as a phytoestrogen. (nih.gov)

The BMD at the top of the hip bone (femoral neck) increase by 1.57 per cent for the high dose isoflavone group, compared to a 0.59 per cent decrease for the placebo group. (nutraingredients-usa.com)
Total cholesterol and low-density lipoproteins were reduced also in the soy isoflavone group compared to placebo. (diagnose-me.com)
No difference in FSH and LH levels were observed between the placebo and the soy isoflavone group. (diagnose-me.com)
In this new trial, 50 people at risk for stroke took a supplement containing 80 milligrams of isoflavones while 52 people with similar health concerns took a placebo. (lesliebeck.com)
The women, none of whom had osteoporosis, were randomly assigned to receive one of two doses daily of isoflavones (80 or 120 mg) or a placebo. (nih.gov)
During three years, women in the isoflavone and placebo groups experienced similar losses in spine, total hip, and whole body BMD. (nih.gov)
To determine whether participants with poorly controlled asthma have improved asthma control and lung capacity when prescribed a soy isoflavone supplement versus a placebo. (nih.gov)
The SOYA trial had 193 participants randomized into the placebo and soy isoflavone arms for a total of 386 participants. (nih.gov)
179 participants in the placebo arm and 166 participants in the soy isoflavone arm completed the trial, which was defined as having an FEV1 measurement at 24 weeks. (nih.gov)
Participants were randomly assigned in a 1:1 allocation ratio to receive either the soy isoflavone supplement or matching placebo twice daily for six months. (nih.gov)
These groups were given the test food (40 mg of soy isoflavone aglycone per day) and placebo, respectively, for 12 wk. (hairloss-research.org)

The objective of this research was to investigate the effects of foliar B fertilizer on seed phenolics (phenol, lignin, and isoflavones) and sugars concentrations. (scirp.org)
Application of B resulted in higher concentrations of total seed B and isoflavones under watered and water-stressed plants. (scirp.org)

The North American Menopause Society suggests that soy isoflavones can also be a natural alternative to estrogen replacement therapy for relief of mild menopausal symptoms. (diagnose-me.com)
The loss of estrogen following menopause can have several effects, including reduction of bone mass, menopausal symptoms, such as hot Jämför priser på Natrol Soy Isoflavone 50mg 120 Kapslar Vitaminer & mineraler. (web.app)
Menopause relief: natrol soy isoflavones is a women's natural dietary supplement designed to help provide menopause relief by naturally reducing hot flashes and night sweats. (inosoc.com)
Menopause focused: Soy isoflavones may have a mild estrogenic effect. (inosoc.com)
Isoflavones such as those from soy have been extensively researched, particularly for their potential use during the menopause. (nutriadvanced.ie)
Research has found that isoflavones may be effective during the menopause at reducing the risks of osteoporosis, lowering cholesterol and preventing hot flushes. (nutriadvanced.ie)
Whilst many women take isoflavones in supplement form as a natural support during the menopause, few instinctively complement this with a probiotic supplement or pay close attention to their dietary habits to ensure it feeds a healthy intestinal microflora. (nutriadvanced.ie)
Researchers supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) provided convincing evidence questioning the notion that soy isoflavone tablets can help preserve bone mineral density (BMD) in women after menopause. (nih.gov)
Studies that tested isoflavones from soy or red clover for their ability to relieve menopause symptoms have had inconsistent results. (nih.gov)

Isoflavones can fight osteoporosis by stimulating bone formation and inhibiting bone resorption. (diagnose-me.com)

Goitrogenic and estrogenic activity of soy isoflavones. (nih.gov)
These effects might be mediated by estrogenic, antiestrogenic and antioxidant activities or other properties of isoflavones [ 1 - 3 ]. (biomedcentral.com)
Soy isoflavones can bind to estrogen receptors in the body and cause either weak estrogenic or anti-estrogenic activity. (web.app)

After 12 weeks, those who were taking the isoflavone supplement saw an improvement in arterial blood flow while those on placebos did not. (lesliebeck.com)
This is the first investigation to detail the beneficial effects of an isoflavone supplement on blood flow in brachial artery, the main blood vessel in the arm. (lesliebeck.com)
If you choose to supplement with isoflavones as a natural menopausal aid, team with a high quality probiotic supplement for fully rounded support. (nutriadvanced.ie)
Soy Isoflavone?Diet Supplement contains 25 mg of the highly absorbable aglycone type of soybean isoflavone, plus lactobionic acid, which supports the beneficial effects of isoflavones. (goodsania.com)

The is great public knowledge about isoflavones and women's health and, while no specific claims can yet be made, this decision will assist with marketing materials, at least on a B2B level. (nutraingredients.com)
In July last year, Acatris reached a deal with ADM allowing it to use substantial intellectual property covering isoflavones and women's health. (foodnavigator.com)
The patents were previously held by Solae and included a range of general patents on isoflavones from all sources, as well as use patents for women's health. (foodnavigator.com)
Non-GMO Super Concentrated Isoflavones Tablets is one of Solgar's premium-quality women's health products. (vitaglo.com)

"These findings form the rationale for future clinical investigation of dietary supplementation with soy isoflavones, or novel inhibitors of the pathway we have identified, as a strategy to ameliorate asthma and other eosinophil- or leukotriene-mediated diseases," concluded Kalhan. (nutraingredients.com)

Some studies have identified potential risks from high intake of isoflavones, such as in women with a history of breast cancer, but this concern has not been substantiated with high-quality clinical research. (wikipedia.org)
Isoflavones are also found in foods of animal origin such as dairy products, meat, eggs and seafood, but the overall contribution to total intake is low. (wikipedia.org)
The aim of this study was to investigate whether soy and isoflavone intake is associated with the prevalence of periodontal disease. (biomedcentral.com)
A significant inverse dose-response relationship between the intake of isoflavones and the prevalence of periodontal disease was observed, although the difference in the adjusted odds ratio between the extreme quintiles was of borderline significance ( P for trend = 0.04). (biomedcentral.com)
Our findings suggest that soy and isoflavone intake may decrease the likelihood of periodontal disease. (biomedcentral.com)
Thus, it is likely that dietary isoflavone intake would affect the host's immune system. (biomedcentral.com)
Oral intake of soy isoflavone aglycone improves the aged skin of adult women. (hairloss-research.org)
These data indicate that the oral intake of 40 mg soy isoflavones per day improves the aged skin of middle-aged women. (hairloss-research.org)

The research demonstrated that foliar B fertilizer altered seed phenol, lignin, isoflavones, and sugars, suggesting that B involved in phenolics and sugar metabolism. (scirp.org)

Soy is a rich dietary source of a group of phytochemicals called isoflavones. (biomedcentral.com)

Because inhibition of thyroid hormone synthesis can induce goiter and thyroid neoplasia in rodents, delineation of anti-thyroid mechanisms for soy isoflavones may be important for extrapolating goitrogenic hazards identified in chronic rodent bioassays to humans consuming soy products. (nih.gov)
These findings have prompted great interest in isoflavones as an alternative to hormone replacement therapy, yet the long-term efficacy of isoflavones on bone in humans is unknown. (nih.gov)
Although the exact role of phytoestrogen on immune activity in humans remains unclear, extensive animal studies showing the effect of isoflavones on immune parameters suggested the feasibility of genistein and daizein as having immunologic effects in humans [ 15 ]. (biomedcentral.com)
Soy isoflavones alone and along with soy proteins lower serum total and LDL cholesterol in humans (Taku et al. (web.app)

During the fermentation of soy derivatives, isoflavones have been transformed into aglycones and are already absorbable. (botanical-online.com)
Moreover, isoflavone aglycones AglyMax stimulated LIF, and TGF-beta secretion , and glycodelin expression in separate primary endometrial epithelial cells in the follicular phase or luteal phase from healthy subject donors . (bvsalud.org)

In this work, scientists synthesized isoflavone 5-deoxy-3′-prenylbiochanin A ( 4 , Figure 1), to study the anti-infective activities of metabolites derived from E. sacleuxii to bacterial pathogens. (cam.ac.uk)
Some of their potential health benefits are dependent on your capacity to convert isoflavones into key metabolites during digestion. (nutriadvanced.ie)

Their study, the longest ever to evaluate the effect of soy isoflavones on BMD, appeared recently in the American Journal of Clinical Nutrition. (nih.gov)

Substituted isoflavone derivatives are related to the parent by the replacement of two or three hydrogen atoms with hydroxyl groups. (wikipedia.org)

Phenolics, including lignin and isoflavones have beneficial effects against diseases when plants are attacked by pathogens [23-25]. (scirp.org)
Soy isoflavones , such as genistein , have been proven to have many beneficial effects. (efloorball.net)

Non-gmo soy: natrol soy Isoflavones uses only the highest-quality non-GMO soy. (inosoc.com)

What are isoflavones and how important is the microbiota? (botanical-online.com)
The effect of isoflavones is closely related to the state of the intestinal microbiota , because it is necessary that isoflavones be transformed so that they can be absorbed and have an effect on the body. (botanical-online.com)
The necessary transformation of isoflavones by the intestinal microbiota or flora shows that the assimilation of these components may be different between different individuals depending on the composition of their intestinal microbiota . (botanical-online.com)
However, the transformation capacity of soy isoflavones by the microbiota remains a pending field for further research. (botanical-online.com)

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp. (propolisscience.org)
The isolated isoflavone formononetin inhibited the growth of all the microorganisms tested, with a minimum inhibitory concentration of 200μg/mL for the six bacteria strains tested and 25μg/mL for the six yeasts. (propolisscience.org)
Taken together our results demonstrate that the isoflavone formononetin is implicated in the reported antimicrobial activity of red propolis. (propolisscience.org)

Several studies have explored the effects of soy isoflavones on bone health, but results have been mixed, ranging from a modest impact to no effect. (nih.gov)

Four weeks of supplementation with genistein, an isoflavone from soy, may suppress the inflammatory process and ease breathing and explain previous reports linking the isoflavone to reduced asthma severity, suggests a new pilot study. (nutraingredients.com)

Conclusions This case emphasizes that consuming health drinks that include soy isoflavone powder extracts can lead to severe hypothyroidism. (medscape.com)
Therefore, this review aims to summarize the anti-inflammatory effects of isoflavones, unravel the underlying mechanisms, and present the potential health risks. (mdpi.com)
And as health-promoting foods continue to rise in popularity, isoflavones have seen strong demand. (foodnavigator.com)
By mimicking human estrogen at certain sites in the body, isoflavones provide many health benefits that help us to avoid disease. (diagnose-me.com)
For example, isoflavones and phenolics are reported to have health benefits as antioxidants against heart disease and cancer [6-9]. (scirp.org)

Nameraka Honpo face wash is a soymilk fermented cleaner that contains soymilk essence and isoflavones that plays a critical role in recreating beautiful and youthful skin for women. (takaski.com)

Previous studies from China have linked soy isoflavones to increases in bone mineral density (BMD), while a recent large study in the Archives of Internal Medicine (2005, Vol. 165, pp. 1890-1895) reported that high soy consumption was linked with a 48 per cent decrease in fractures for women who had been menopausal for less than 10 years. (nutraingredients-usa.com)
Soy isoflavones have long been a staple in Asian diets, and there appears to be an increase, albeit modest, compared to Asian populations, in soy consumption among Americans. (mdpi.com)
It could be that the Orientals had a greater capacity to transform isoflavones at the intestinal level due to the tradition of consumption of this legume , which is only found in western food occasionally or temporarily. (botanical-online.com)
However, no published studies have examined the effects of consumption of soy and isoflavones on periodontal disease. (biomedcentral.com)
The cosmetic benefits of Soy Isoflavone consumption don't stop there. (hairloss-research.org)
Recent studies have shown oral Soy Isoflavone consumption stimulates collagen production and firms facial skin. (hairloss-research.org)

Some early research has suggested possible benefits from soy proteins (called isoflavones) in lowering prostate cancer risk. (cancer.org)

Overall, our findings suggest that isoflavones may alter the uterine expression of estrogen -responsive genes . (bvsalud.org)

Recently, some studies have raised concerns about isoflavones induced negative effects like carcinogenesis, thymic involution, and immunosuppression. (mdpi.com)
Isoflavones may help reduce breast cancer by blocking the cancer-causing effects of human estrogen . (diagnose-me.com)
It seems your composition of colonic microflora can significantly influence the biologic effects of isoflavones. (nutriadvanced.ie)
And, while researchers did not identify negative effects in soy users, the commonly held, but incorrect public view that soy isoflavones are bone-protective in healthy American women is seriously called into question. (nih.gov)

Increasing evidence has highlighted the potential for isoflavones to prevent the chronic diseases in which inflammation plays a key role, though the underlying mechanisms remain unclear. (mdpi.com)

ADM is one of the leading suppliers of soy isoflavones along with Acatris and Solbar. (foodnavigator.com)

The COMBINATION of Soy Isoflavones and Green Tea lowers DHT by 80% in animal models, and as discussed in a recent update, confers specific anti-inflammatory benefits on androgen induced inflammation. (hairloss-research.org)

Isoflavones are a class of flavonoids that exhibit antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. (mdpi.com)

Why is intestinal flora so important for isoflavones absorption? (botanical-online.com)
Eating soy usually increases intestinal bacteria capable of metabolizing isoflavones. (botanical-online.com)
In both cases, isoflavones are absorbed directly (they are more bioavailable) without having to be metabolized by the intestinal flora to assimilate. (botanical-online.com)

Among risky foods lowering thyroid function, some experimental studies have revealed that isoflavones reduce thyroid function. (medscape.com)

Soy isoflavones have antioxidant properties which protect the cardiovascular system from oxidation of LDL (the bad) cholesterol . (diagnose-me.com)

Previous studies had shown that those who consume soy isoflavones have better lung function compared to those who do not. (nih.gov)

Organisms3

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes4

Technology, Industry, Agriculture6

Health Care2

Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. (1/1619)

Dietary isoflavones: biological effects and relevance to human health. (2/1619)

Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. (3/1619)

Daidzein and genistein but not their glucosides are absorbed from the rat stomach. (4/1619)

Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity. (5/1619)

Soybean isoflavones reduce experimental metastasis in mice. (6/1619)

Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein. (7/1619)

Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. (8/1619)

Isoflavones

Soybean Proteins

Soybeans

Soy Foods

Phytoestrogens

Equol

Genistein

Soy Milk

Pueraria

Trifolium

Estrogens, Non-Steroidal

Plant Preparations

Diet

Coumestrol

Postmenopause

Lignans

Plant Extracts

Dietary Supplements

Vegetable Proteins

Biological Availability

Phytotherapy

Anticarcinogenic Agents

Cross-Over Studies

Double-Blind Method

Premenopause

Flavonoids

Pterocarpans

Caseins

Chromans

Ovariectomy

Chromatography, High Pressure Liquid

Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. (1/1619)

Dietary isoflavones: biological effects and relevance to human health. (2/1619)

Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. (3/1619)

Daidzein and genistein but not their glucosides are absorbed from the rat stomach. (4/1619)

Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity. (5/1619)

Soybean isoflavones reduce experimental metastasis in mice. (6/1619)

Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein. (7/1619)

Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. (8/1619)

Isoflavone

Luteone (isoflavone)

Retusin (isoflavone)

Isoflavone 2'-hydroxylase

Isoflavone 3'-hydroxylase

Monoprenyl isoflavone epoxidase

Isoflavone 7-O-methyltransferase

Isoflavone 7-O-glucosyltransferase

Isoflavone 4'-O-methyltransferase

Isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase

Prunetin

Soybean

Alice H. Lichtenstein

Homoisoflavonoid

Daidzein

Eucomis autumnalis

Iris hookeriana

Genistein

Iris kashmiriana

Iris milesii

Iridin

Iris kemaonensis

Iris songarica

Streptomyces roseolus

Coumestrol

Prunus emarginata

Sarcolobus globosus

Barbigerone

Rotenoid

Andira humilis

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