*  Neuropathy, what does it feel like? - Thyroid Disorders - MedHelp

Doc is also trying to increase my immune system which is showing low. (CD57). Since it's so difficult for me to keep my Vit.D ... I have 'autoimmune phenomenon' per my diagnose from my Rhuematologist and Neurologist. My EMG's, SSEP, and others came out ... Doc is also trying to increase my immune system which is showing low. (CD57). Since it's so difficult for me to keep my Vit.D ... Was told that Lymes reduces the immune system which in turn causes autoimmune issues. Hashi is common with Lymes as I was told ...
medhelp.org/posts/Thyroid-Disorders/Neuropathy--what-does-it-feel-like/show/1212739

*  Scleroderma | Doctors Hospital

Malfunction of the immune system may contribute to excess collagen production.. Risk Factors. Scleroderma is more common in ... Also involves Raynaud phenomenon. Certain categories of this form of scleroderma are more serious and can be fatal. *Limited *A ... Treatments are aimed at relieving symptoms in various systems.. Joints and Muscles. *Nonsteroidal anti-inflammatory drugs ( ... Complications of diffuse scleroderma can affect virtually every system of the body. Other common complications include:. *Skin ...
doctors-hospital.net/hl/?/11575/Scleroderma&com.dotmarketing.htmlpage.language=1

*  Researchers Unlock The Secret Of Bacteria's Immune System - Redorbit

This phenomenon could explain, among other things, why some bacteria develop antibiotic resistance while others don't." ... The CRISPR/Cas immune system also protects bacteria from bacteriophages, a group of viruses that specifically target bacteria. ... A team of Universit© Laval and Danisco researchers has just unlocked the secret of bacteria's immune system. The details of the ... These segments then serve as a kind of immune factor in fighting off future invasions by cleaving incoming DNA. ...
redorbit.com/news/health/1944716/researchers_unlock_the_secret_of_bacterias_immune_system/

*  Keyword: space

How our immune systems could stop humans reaching Mars. 09/02/2017 10:24:47 AM PDT · by LibWhacker · 48 replies The Telegraph ^ ... Physicists have since demonstrated the spooky phenomenon to be possible, but now they want to extend its reach. A new study ... The human immune system is so weakened by space travel that even a simple virus could prove deadly [...snip...] Yet although we ... our own immune system. Although it is said we are all made of star stuff when it comes to travelling away from our home planet ...
freerepublic.com/tag/space/index

*  The Alternative-Doctor - VACCINATION: RISKS AND ALTERNATIVES

General damage to the immune system. *Slow viruses. *Genetic abnormalities - 'Jumping Gene' phenomenon ... Thus, clear evidence is emerging of a long term weakening of the immune system due to vaccination.. Dr. Robert Gallo, the US ... injections of antigens tend to both sensitise the recipient to the disease and destroy the vitality of the immune system on a ... Constitutional treatment that will elevate general vitality and immune competence.. If desired, parents may support the above ...
alternative-doctor.com/vaccination/giorgiougolden.htm

*  Selective De-Worming

Because the kidding and nursing are stressful conditions, the dam's immune system is compromised. Furthermore, nutrients are ... A phenomena called the "per-parturient rise" (PPR) in fecal egg output. This occurs at or around kidding time and extends ... This helps keep some of the less resistant parasites in the system to help minimize the number of "super parasites" in your ... This means the drugs may go thru the goats system faster than other animals. Since most parasite drugs are actually developed ...
jackmauldin.com/selective_deworming.html

*  Recent Articles | Dna, Immunology And Genetics & Genomics | The Scientist Magazine®| Page 41

The virus can persist in several tissues where the immune system is less active. Researchers are working to better understand ... this phenomenon and how it can stall the clearing of Ebola in survivors. ...
the-scientist.com/?articles.list/tagNo/235,12,9/tags/DNA,immunology,genetics--amp--genomics/pageNo/41/

*  Recent Articles | Digital Pcr, Immunology And Neuroscience | The Scientist Magazine®| Page 31

The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the ... Researchers are working to better understand this phenomenon and how it can stall the clearing of Ebola in survivors. ... The virus can persist in several tissues where the immune system is less active. ...
the-scientist.com/?articles.list/tagNo/1314,12,11/tags/digital-PCR,immunology,neuroscience/pageNo/31/

*  Recent Articles | Us Supreme Court And Immunology | The Scientist Magazine®| Page 10

The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the ... Researchers are working to better understand this phenomenon and how it can stall the clearing of Ebola in survivors. ... The virus can persist in several tissues where the immune system is less active. ... Immune Cells Can Deliver Deadly Packages. By Amanda B. Keener , September 8, 2015 ...
the-scientist.com/?articles.list/tagNo/1942,12/tags/US-Supreme-Court,immunology/pageNo/10/

*  Considering the Mechanisms and Treatment of Inflammaging - Fight Aging!

That said, you may find the rest of the paper to be an interesting view of the way in which the immune system runs awry in ... In the process of aging, some researchers pointed out that the phenomenon where adaptive immunity declines is called ... The molecular damage of aging and a lifetime of exposure to pathogens produces an aged immune system that is both overactive ... Even if you stay in shape, however, the immune system becomes increasingly disarrayed in ways that provoke inflammation. ...
https://fightaging.org/archives/2016/08/considering-the-mechanisms-and-treatment-of-inflammaging/

*  Sparse Structural Equation Models for Gene Networks and Chemical Genomics - Xiaodong Cai

Structural equation modeling unifies regression, factor analysis, directed graphs and other (non)linear models into a powerful and flexible toolbox for statisti...
grantome.com/grant/NIH/R01-GM104975-03

(1/10) Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation.

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(2/10) Inhibitory RNA molecules in immunotherapy for cancer.

 (+info)

(3/10) The ancestry and cumulative evolution of immune reactions.

The last two decades of study enriched greatly our knowledge of how the immune system originated and the sophisticated immune mechanisms of today's vertebrates and invertebrates developed. Even unicellular organisms possess mechanisms for pathogen destruction and self recognition. The ability to distinguish self from non-self is a prerequisite for recognition of sexual compatibility and ensuring survival. Molecules involved in these processes resemble those found in the phagocytic cells of higher organisms. Recognition of bacteria by scavenger receptors induces phagocytosis or endocytosis. The phagocytic mechanisms characterizing the amoeboid protozoans developed further during the evolution towards innate immunity. The scavenger receptor cysteine-rich domain SRCR is encoded in the genomes from the most primitive sponges to mammals. The immune system of sponges comprises signal transduction molecules which occur in higher metazoans as well. Sponges already possess recognition systems for pathogenic bacteria and fungi, based on membrane receptors (a lipopolysaccharide-interacting protein, a cell surface receptor recognizing beta(1 --> 3)-d-glucans of fungi). Perforin-like molecules and lysozymes are involved, among others, in defense in sponges. Reactive oxygen and nitrogen species function in the immunity of early metazoan. Genes encoding the family of reactive oxygen-generating NADPH oxidases (Noxes) are found in a variety of protists and plants. The NO synthases of cnidarians, mollusks, and chordates are conserved with respect to the mammalian NOS. The antimicrobial peptides of protozoans, amoebapores, are structural and functional analogs of the natural killer cell peptide, NK-lysin, of vertebrates. An ancestral S-type lectin has been found in sponges. Opsonizing properties of lectins and the ability to agglutinate cells justify their classification as primitive recognition molecules. Invertebrate cytokines are not homologous to those of vertebrate, and their functional convergence was presumably enabled by the general similarity of the lectin-like recognition domain three-dimensional structure. Sponges contain molecules with SCR/CCP domains that show high homology to the mammalian regulators of complement activation (RCA family). A multi-component complement system comprising at least the central molecule of the complement system, C3, Factor B, and MASP developed in the cnidarians and evolved into the multilevel cascade engaged in innate and acquired immunity of vertebrates. The adaptive immune system of mammals is also deeply rooted in the metazoan evolution. Some its precursors have been traced as deep as in sponges, namely, two classes of receptors that comprise Ig-like domains, the receptor tyrosine kinases (RTK), and the non-enzymic sponge adhesion molecules (SAM). The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T-cell receptor (TCR), B-cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes. However, genes closely resembling RAG1 and RAG2 have been uncovered in the genome of a see urchin. The ancestry of MHC gene remains unknown. Similarly, no homologue of the protein binding domain (PBD) in MHC molecules has been found in invertebrates. The pathway by which endogenous peptides are degraded for presentation with class I MHC molecules utilizes mechanisms similar to those involved in the normal turnover of intracellular proteins, apparently recruited to work also for the immune system. Several cDNAs coding for lysosomal enzymes, e.g., cathepsin, have been isolated from sponges. All chromosomal duplication events in the MHC region occurred after the origin of the agnathans but before the gnathostomes split from them. The V-domains of the subtype found in the receptors of T and B-cells are known from both agnathans and cephalochordates, although they do not rearrange. The rearrangement mechanism of the lymphocyte V-domains suggests its origin from a common ancestral domain existing before the divergence of the extant gnathostome classes. Activation-induced deaminase (AID) - homologous proteins have been found only in the gnathostomes. It appears thus that the adaptive immunity of vertebrates is a result of stepwise accumulation of small changes in molecules, cells and organs over almost half a billion years.  (+info)

(4/10) Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.

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(5/10) IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts.

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(6/10) Role of notch signaling in osteoimmunology--from the standpoint of osteoclast differentiation.

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(7/10) Computational approaches to understanding dendritic cell responses to influenza virus infection.

 (+info)

(8/10) Evolution of vertebrate immunity.

 (+info)



body's


  • Researchers at Penn State are trying to trick the body's immune system, and increase the circulation time of nano drug carriers in the blood, with stealth drug nanoparticles that could be fabricated by self-assembling a shell on the surface of a solid drug core. (nanowerk.com)
  • The 2007 Albert Lasker Award for Basic Medical Research honors the scientist who discovered dendritic cells, the preeminent component of the immune system that initiates and regulates the body's response to foreign antigens. (laskerfoundation.org)
  • When functioning normally, the complement system is an important part of the body's immune system, killing harmful bacteria and cells infected by viruses when it is called upon to do so. (news-medical.net)

tissues


  • The virus can persist in several tissues where the immune system is less active. (the-scientist.com)
  • Inflammation is a necessary part of the immune response, but if the switch is jammed in the on position, that inflammation produces a growing burden of damage to tissues and organs. (fightaging.org)
  • Such interactions among co-infecting parasites, host tissues and the immune system can be viewed as a network [ 16 ]. (royalsocietypublishing.org)
  • Scientists had discovered that lymphocytes, a group of cells in the blood and other immune-related tissues, play key roles in fighting microbial trespassers. (laskerfoundation.org)

elicit


  • We take advantage of an immune system that the bees elicit for viral disease. (israel21c.org)
  • The network had three levels comprising parasites, the resources they consume and the immune responses they elicit, connected by potential, observed and experimentally proved links. (royalsocietypublishing.org)

bacteria


  • This phenomenon could explain, among other things, why some bacteria develop antibiotic resistance while others don't. (redorbit.com)
  • The CRISPR/Cas immune system also protects bacteria from bacteriophages, a group of viruses that specifically target bacteria. (redorbit.com)
  • The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows. (the-scientist.com)
  • For example, B cells produce antibodies, which attach to bacteria and mark them for destruction by other components of the immune system. (laskerfoundation.org)

Joints


  • Challenging long-held notions that osteoarthritis is a result mainly of wear and tear on the joints, researchers led by Dr. William H. Robinson of the Department of Veterans Affairs Palo Alto Health Care System and Stanford University have provided new insights into the immune-system changes that may trigger cartilage breakdown. (news-medical.net)
  • The researchers discovered that one component of the complement system, called the membrane attack complex, or MAC, is formed and activated in the joints of both humans and mice affected by osteoarthritis. (news-medical.net)
  • They believe that when the MAC is aberrantly activated in the joints (a phenomenon called 'dysregulation'), it induces low-grade inflammation and the production of enzymes that break down cartilage and result in the development of osteoarthritis . (news-medical.net)

Researchers


  • Researchers are working to better understand this phenomenon and how it can stall the clearing of Ebola in survivors. (the-scientist.com)
  • To better understand lymphocytes' functions and interactions, researchers wanted to re-create aspects of the immune response in culture dishes. (laskerfoundation.org)

Inflammation


  • Inflammaging is very focused on chronic inflammation , as you might imagine, while immunosenescence is focused on the declining effectiveness of the immune response. (fightaging.org)
  • Even if you stay in shape, however, the immune system becomes increasingly disarrayed in ways that provoke inflammation. (fightaging.org)

parasites


  • If a goat only has the most resistant parasites in their system, the breeding can only produce similar strong, resistant parasites. (jackmauldin.com)
  • This helps keep some of the less resistant parasites in the system to help minimize the number of "super parasites" in your herd. (jackmauldin.com)
  • Pairs of parasite species had most potential to interact indirectly through shared resources, rather than through immune responses or other parasites. (royalsocietypublishing.org)
  • These phenomena are likely driven by interactions among co-infecting parasites [ 14 ]. (royalsocietypublishing.org)
  • However, we do not know the frequency of 'bottom-up' resource-mediated or 'top-down' immune-mediated interactions among parasites [ 16 ], or how they are modified by the introduction of new parasites [ 25 ], despite considerable biological interest in the topic. (royalsocietypublishing.org)

disorders


  • The pharmaceutical composition and bioactive component may be used to enhance immune competency, treat disorders associated with the immune system, inhibit the inflammatory response, treat disorders associated with the inflammatory response, enhance the anti-tumor response, and treat disorders associated with the response to tumor formation and growth, all in mammals. (google.es)

viruses


  • Phagocytosis is a cellular phenomena that describes the process in which phagocytes (specialized cells such as macrophages) destroy viruses and foreign particles in blood. (nanowerk.com)

less


  • This is more or less the opposite view on strategy from the systems biology perspective put forward in this paper. (fightaging.org)

cells


  • At a time when conventional wisdom pointed in other directions, Ralph Steinman proposed that these cells propel other immune cells into action and then pursued that possibility with careful and dedicated experimentation. (laskerfoundation.org)
  • In the last 34 years, Steinman's work has revealed that dendritic cells scour the environment for microbial invaders and stimulate the T cells of the immune system to respond. (laskerfoundation.org)
  • These T cells, in turn, prompt other immune cells to eliminate the threat. (laskerfoundation.org)
  • His work spawned a major discipline, with hundreds of investigators worldwide studying these cells and their roles in multiple aspects of immune regulation. (laskerfoundation.org)
  • Recent studies have shown that dendritic cells also contribute to tolerance, the process by which the body quiets potential immune reactions to its own cells. (laskerfoundation.org)
  • In the 1950s, immunologists proposed that immune cells use receptor molecules on their external surfaces to recognize invading germs and other foreign particles, or antigens. (laskerfoundation.org)
  • When he peered through the microscope at his spleen-derived substance, he noticed not only macrophages and other established immune cells, but rare, irregularly shaped cells that no one had described before. (laskerfoundation.org)

common


  • You would think if something was a dangerous and common phenomenon that I would be seeing it. (getbetterhealth.com)

response


  • He revolutionized our understanding of the events that instigate an immune response and unlocked the entire field of T-cell activation. (laskerfoundation.org)

disease


  • Many cases of limited disease begin gradually with Raynaud's phenomenon . (wellmont.org)

important


  • Phagocytes are an important part of the immune system. (nanowerk.com)
  • Working with samples from humans with osteoarthritis and mice, the research team found that the complement system, a group of proteins that move freely through the bloodstream, plays an important role in the development and spread of osteoarthritis. (news-medical.net)

active


  • A new class of biologically-active copolymers is provided capable of effecting biological systems in many different ways. (google.com)

things


  • The authors here differentiate between inflammaging and immunosenescence , though I'm not convinced that these are really distinct enough to be considered two separate things given the present understanding of immune dysfunction in aging. (fightaging.org)

Problems


  • The difference is probably that when implants are properly placed inside a woman's breasts, her immune system helps protect them from such problems. (getbetterhealth.com)

potential


  • The growing efforts of physicists and materials scientists to fabricate photonic (nano)crystals were motivated mainly by the potential application of these materials in optical computing, the manufacturing of more efficient lasers, and other exciting new phenomena, like those arising from the application of disturbances such as shock waves. (nanowerk.com)

time


  • The molecular damage of aging and a lifetime of exposure to pathogens produces an aged immune system that is both overactive and ineffective at the same time. (fightaging.org)

causes


  • This is driven by a strategic approach that ignores the search for root causes in favor of evaluating the dysfunctional system as a whole and seeking to alter its operation, to force it into a mode of operation that resembles that of youth and health. (fightaging.org)

colonising new


  • Yet although we now have the technological ability to leave Earth, scientists have found another stumbling block to colonising new worlds - our own immune system. (freerepublic.com)