*  November 2013 - Volume 19 - Issue 12 : Inflammatory Bowel Diseases

Gene Expression Profiles of Ileal Inflammatory Bowel Disease Correlate with Disease Phenotype and Advance Understanding of Its ... Impact of JC Virus Antibody Testing in Patients with Crohn's Disease with Loss of Response to Infliximab: A Markov Model. Scott ... Keeping the Bowel Regular: The Emerging Role of Treg as a Therapeutic Target in Inflammatory Bowel Disease. Gibson, David J.; ... The Clinical Utility of Health-Related Quality of Life Screening in a Pediatric Inflammatory Bowel Disease Clinic. Ryan, Jamie ...

*  December 2011 - Volume 17 - Issue 12 : Inflammatory Bowel Diseases

Efficacy and safety of endoscopic treatment of ileal pouch strictures. Shen, Bo; Lian, Lei; Kiran, Ravi P.; More ... Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002- ... Drug development in inflammatory bowel disease: The role of the FDA. Lahiff, Conor; Kane, Sunanda; Moss, Alan C. ... Methotrexate in the treatment of inflammatory bowel disease: An 8‐year retrospective study in a Canadian pediatric IBD center. ...

*  September 2010 - Volume 16 - Issue 9 : Inflammatory Bowel Diseases

Evaluation of endoscopic and imaging modalities in the diagnosis of structural disorders of the ileal pouch. Tang, Linda; Cai, ... CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice. Maharshak, N.; Hart, G.; Ron, E.; More ... Activated factor XI and tissue factor in inflammatory bowel disease. Undas, A.; Owczarek, D.; Gissel, M.; More ... Treatment‐associated acute myeloid leukemia in a patient with Crohn's disease on 6‐mercaptopurine. Das, Koushik K.; Nishino, Ha ...

*  Refined mapping finds over 200 Crohn's Disease genes

Researchers have used a genetic mapping technique to identify more than 200 genes associated with Crohn's Disease, making it ... their effects extended to people with extra-ileal as well as ileal inflammation. ... Tags: Crohn's Disease, Crohn's Disease, Diabetes, Gene, Genes, Genetic, Genetics, Genome, Immune System, Kidney, Nephrology, ... "The discovery of so many gene locations for Crohn's Disease is an important step forward in understanding the disease, which ...

*  Ghent University Academic Bibliography

Small animal PET-CT as a non-invasive method to evaluate terminal ileal inflammation in a murine model of Crohn's disease ... Profile of Belgian Pediatric Crohn Disease (CD) patients: presentation and diagnostic features E De Greef, I Hoffman, FN Smets ... Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease F Baert, L Moortgat, G Van ... Profile of Belgian Pediatric Crohn's Disease (CD) patients: associations between variables at diagnosis E De Greef, I Hoffman, ...
https://biblio.ugent.be/publication?q=parent exact "GASTROENTEROLOGY"&limit=20

*  Efficacy and Safety Study of Oral Eligen® B12 in Subjects With Low Serum Cobalamin - Full Text View - ClinicalTrials.gov

... ileal resection, gastric atrophy, Celiac disease, Crohn's disease, or prolonged use (,3 months) of proton pump inhibitor drugs ... Deficiency Diseases. Malnutrition. Nutrition Disorders. Vitamin B 12. Hydroxocobalamin. Vitamin B Complex. Vitamins. ...

*  Plus it

... supporting ileal mucosa colonization in Crohn disease. J Clin Invest 117: 1566-1574, 2007. ... Patchy distribution of mucosal lesions in ileal Crohn's disease is not linked to differences in the dominant mucosa-associated ... Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 84: 282-291, ... Ohkusa T, Nomura T, Sato N. The role of bacterial infection in the pathogenesis of inflammatory bowel disease. Intern Med 43: ...

*  Nonimmunoglobulin E-Mediated Immune Reactions to Foods | SpringerLink

Bellanti JA, Zeligs BJ, Malka-Rais J, Sabra A: Abnormalities of Th1 function in non-IgE food allergy, celiac disease, and ileal ... Celiac Disease. Celiac disease is a specific food protein-induced autoimmune enteropathy in which the body reacts to gliadin, ... as compared to abnormal CD4/CD8 ratios in the celiac disease group. As compared with the celiac disease patients, there was a ... Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA ...

*  Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal...

We have previously reported that ileal interposition (IT) ... Targeting bile-acid signalling for metabolic diseases. Nat. Rev ... Cummings B. P.,Strader A. D.,Stanhope K. L.,Graham J. L.,Lee J.,Raybould H. E.,Baskin D. G.,Havel P. J.. (Year: 2010c). Ileal ... Title: Disease models & mechanisms Volume: - ISSN: 1754-8411 ISO Abbreviation: Dis Model Mech Publication Date: 2012 Dec ... The isolated ileal segment was then inserted isoperistaltically Sham-operated animals were treated in the same manner as the IT ...

*  Enteroaggregative Escherichia coli - Volume 4, Number 2-June 1998 - Emerging Infectious Disease journal - CDC

Infection with EAEC strains in rabbit and rat ileal loop models resulted in a destructive lesion demonstrable by light ... Centers for Disease Control and Prevention, * National Center for Emerging and Zoonotic Infectious Diseases (NCEZID). Office of ... Emerging Infectious Disease journal ISSN: 1080-6059 Note: Javascript is disabled or is not supported by your browser. For this ... Emerging Infectious Diseases. 1998;4(2):251-261. doi:10.3201/eid0402.980212.. APA. Nataro, J. P., Steiner, T., & Guerrant, R. L ...

(1/280) Two way push videoenteroscopy in investigation of small bowel disease.

AIMS: To evaluate the diagnostic yield and safety of a new push type videoenteroscope (PVE) for diagnosis of small bowel disease. METHODS: Three hundred and thirteen patients were referred for one or two way PVE from December 1993 to June 1996. Indications for PVE were: an unexplained iron deficiency anaemia with or without clinically evident gastrointestinal bleeding; or a complementary investigation for suspected small bowel disease, after a small bowel barium follow through (SBBFT) considered as normal or abnormal, but without a definite diagnosis. RESULTS: A jejunoscopy and a retrograde ileoscopy were carried out in 306 and 234 patients, respectively. In patients with isolated anaemia (n = 131) and those with clinically evident gastrointestinal bleeding associated anaemia (n = 72), PVE provided a diagnosis in 26 (19.8%) and 22 (30.5%) cases, respectively. Lesions found were located in the jejunoileum in 30 (14.7%) patients and in the gastroduodenum or the colon in 18 (8.8%) patients--that is, within the reach of the conventional gastroscope/colonoscope. In patients with normal (n = 54) or abnormal (n = 56) SBBFT, PVE provided a diagnosis in 17 (31%) and 27 (48%) cases, respectively. In 25% of cases, the abnormal appearance of SBBFT was not confirmed. The site of the radiological abnormality was not reached in 27% of cases. Lesions were located at the jejunum and the ileum in 59 (64%) and 33 (36%) cases, respectively. CONCLUSIONS: PVE is useful in around 30% of cases of unexplained anaemia or after an SBBFT which failed to provide an accurate aetiological diagnosis. Use of retrograde videoenteroscopy increases diagnostic yield by one third.  (+info)

(2/280) Small intestinal ulceration secondary to carcinoid tumour arising in a Meckel's diverticulum.

A solitary small intestinal ulcer associated with a carcinoid tumour in a nearby Meckel's diverticulum was found in a 77 year old man presenting with massive rectal bleeding. Angiography and a radioisotope study localised the bleeding to the ileum. At operation, the Meckel's diverticulum was identified, with bleeding from an ulcer just distal to it. Pathological examination revealed a small carcinoid tumour confined to the Meckel's diverticulum. Close to the opening of the diverticulum, within the ileum, a well demarcated ulcer was present. Histology showed a non-specific ulcer which eroded a large blood vessel. This is the first documented occurrence of solitary small intestinal ulceration in association with a carcinoid tumour. Carcinoid tumour should be added to the list of possible causes of small intestinal ulceration. The ulceration may be secondary to release of cytokines by the tumour.  (+info)

(3/280) The effect of octreotide on postoperative adhesion formation.

OBJECTIVE: To investigate the effect of octreotide, a long-acting analogue of somatostatin, on postoperative adhesion formation, because somatostatin inhibits secretion of some growth factors that have modulatory effects on collagen synthesis. DESIGN: An experimental study. SETTING: Surgical Research and Biochemistry laboratories at Hacettepe University, Ankara, Turkey. SUBJECTS: Male Swiss albino mice. INTERVENTIONS: Both sides of a 5-cm ileal segment from Swiss albino mice were scraped 10 times, and transient ischemia was induced by clamping the segmental artery. Animals were injected subcutaneously with 1 mL/d of saline for 3 days (group 1), a single 5-mL intraperitoneal dose of saline (group 2), subcutaneously with 10 micrograms/kg daily of octreotide for 3 days (group 3) or a single 10 micrograms/kg intraperitoneal dose of octreotide (group 4). In half of the animals repeat laparotomy was performed on postoperative day 5. After adhesions were graded, the scraped ileal segments were excised for determination of hydroxyproline quantity. The same procedure was repeated on postoperative day 14 for the remaining animals. OUTCOME MEASURES: Adhesion grading, hydroxyproline levels. RESULTS: On postoperative day 5, the intraperitoneal octreotide group (group 4) had a significantly lower median adhesion score than groups 1 and 2. On postoperative day 14, both octreotide groups (3 and 4) had a significantly lower median adhesion grading than both saline groups (1 and 2). Hydroxyproline levels of the groups were not significantly different on either day 5 or day 14. CONCLUSION: Octreotide has a beneficial effect in decreasing adhesion formation in the early postoperative period.  (+info)

(4/280) Multilocular pyogenic hepatic abscess complicating ascaris lumbricoides infestation.

A 74-year-old man was admitted to our hospital with frequent right flank pain. The multiple multilocular hepatic abscesses were revealed by computed tomography. Radiographs following a barium meal showed a linear filling defect in the ileum consistent with ascariasis. One day after treatment with pyrantel pamoate, an Ascaris was passed in the stool. The pyogenic hepatic abscesses gradually healed with both antibiotics and continuous drainage. After 2 months, he was discharged. In this case, the pyogenic hepatic abscesses were thus considered to have been caused by an inflammation which spread through the portal vein.  (+info)

(5/280) Acute bowel perforation in a fetus with gastroschisis.

Gastroschisis is a congenital anomaly with a reported incidence of 1 in 10,000 live births. Although prenatal diagnosis is more common with the widespread use of biochemical markers and obstetric ultrasound, the role of ultrasound in the identification of the fetus that might need early intervention has not been established. Acute bowel perforation was diagnosed by ultrasound at 34 weeks gestation in a fetus with gastroschisis. An immediate Cesarean section was performed, followed by repair with primary closure. The neonatal outcome was favorable. The post-partum findings, including bowel pathology, confirmed the antenatal diagnosis. Acute bowel perforation can be diagnosed antenatally. Immediate intervention, before further bowel injury occurs, might enhance the ability of the surgeon to perform primary closure and obtain a favorable outcome.  (+info)

(6/280) Laparoscopic-assisted resection of ileal lipoma causing ileo-ileo-colic intussusception.

Adult intussusception is rare, and the majority of cases has an underlying cause that requires surgical resection. We report a case of a 39 yr-old man with ileo-ileo-colic intussusception caused by ileal lipoma that was successfully managed by a laparoscopic-assisted surgical maneuver. Using a three-cannula technique, ileo-colic intussusception was reduced laparoscopically. Then, through a 4-cm transverse incision in the right lower quadrant abdomen, ileo-ileal intussusception was reduced manually, and a resection of the tumor-bearing ileal segment and end-to-end anastomosis was performed extracorporeally. Although the role of laparoscopy in managing intussusception is not clearly defined, laparoscopy may be an alternative approach to the surgical treatment of adult intussusception in selected cases.  (+info)

(7/280) Lower gastrointestinal bleeding due to cytomegalovirus ileal ulcers in an immunocompetent man.

Cytomegalovirus (CMV) infections are commonly reported in severely immunocompromised hosts and ulcers of the alimentary tract are frequently observed in systemic CMV infections. However, invasive and ulcerative disease of the gastrointestinal (GI) tract caused by CMV has also been reported in healthy adults. Many reports show that a CMV infection can produce localized ulcerations in the esophagus, stomach, small intestine, and colon in nonimmunocompromised individuals. The most common site of involvement by CMV infection in the GI tract is the colon followed by the upper GI tract and the least common site is the small intestine. Although GI bleeding is one of the major presenting symptoms of patients with CMV infections of the GI tract, lower GI bleeding due to CMV ileal ulcers in immunocompetent patients, to our knowledge, has not been reported in the English literature. Recently, we experienced a case of lower GI bleeding due to CMV ileal ulcers in a 57-year-old man who had no evidence of immunocompromise. This case suggests that small intestinal ulcers due to CMV infection should be included in the differential diagnosis of lower GI bleeding even in immunocompetent hosts.  (+info)

(8/280) Intussusception associated with bacterial meningitis.

Despite its common association with viral illnesses, intussusception has only rarely been found in the presence of bacterial infections. Two infants are described, both of whom were admitted to hospital with bilious vomiting, drowsiness, and dehydration. Both infants required urgent intravenous volume expansion. Intussusception was confirmed, and reduction was achieved by enema in both cases. Recovery was slow, and one infant developed a seizure. Evidence of meningococcal meningitis was found in both, with septicaemia in one. Neurological outcome is normal to date, and there has been no recurrence of intussusception in either case.  (+info)

interposition surgery

  • Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. (biomedsearch.com)
  • They found that the rats receiving the ileal interposition surgery developed type 2 diabetes 120 days later than did the rats in the control group. (ucdavis.edu)

Crohn's Disease

  • Researchers have used a genetic mapping technique to identify more than 200 genes associated with Crohn's Disease (CD), making it the most well-characterized disorder to date. (news-medical.net)
  • Senior author Nikolas Maniatis (University College London, UK) said in a press statement: "The discovery of so many gene locations for Crohn's Disease is an important step forward in understanding the disease, which has a very complicated genetic basis. (news-medical.net)
  • Impairment of this barrier function leading to the increased permeability to luminal antigens has been proposed as an initiating factor in the pathogenesis of chronic human inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) that are characterized by aberrant immune responses against microorganisms that are present in the intestine. (physiology.org)
  • The importance in distinguishing ileal TB from Crohn's disease is further highlighted because the treatment is vastly different. (asmscience.org)
  • Crohn's disease can occur at any age, but people in their mid-twenties are most likely to be affected. (emedmd.com)
  • The risk of developing Crohn's disease is higher in people who have a close relative with the disorder. (emedmd.com)
  • Crohn's disease can also affect the colon (the major part of the large intestine), causing bloody diarrhoea. (emedmd.com)
  • It may be difficult to differentiate between Crohn's disease when it is affecting the colon and ulcerative colitis, an inflammatory bowel disease limited to the large intestine. (emedmd.com)
  • Crohn's disease is a common form of chronic inflammatory bowel disease, typically involving the terminal ileum, colon and perineum and causing discontinuous transmural inflammation characterized microscopically by granulomata and macroscopically by fibrotic strictures and fistulae. (emedmd.com)
  • The trigger for Crohn's disease is unknown, but an unregulated mucosal immune response to commensal bacteria drives the chronic inflammation. (emedmd.com)
  • The peak incidence of Crohn's disease is in early adulthood. (emedmd.com)
  • Crohn's disease is a chronic inflammatory disease that can affect any segment of the intestinal tract, with a peak of incidence between 25 and 35 years of age affecting 2-7/100000 people per year. (unipd.it)
  • More than 33% of patients suffering from Crohn's disease develop intestinal stenosis, preferentially in the small intestine, within 10 years of diagnosis and the only treatment available is surgery. (unipd.it)
  • The repairing process of an organ after a chronic damage, like Crohn's disease, is a delicate balance between the production of new extracellular matrix and destruction of the excess. (unipd.it)
  • a known profibrogenic cytokine, that shows high expression in the tissue affected by excessive fibrosis in Crohn's disease. (unipd.it)
  • Recently, the role of TAK1 has been associated with cardiac hypertrophy and renal fibrosis, this prompted us to investigate its role in the fibrogenic process in Crohn's disease. (unipd.it)
  • To study the involvement of TAK1 in fibrogenetic Crohn's disease we initially determined the expression levels and phosphorylation status of the protein in the ileal mucosa obtained from patients undergoing surgical resection for stenosis and in normal ileum specimens obtained from patients undergoing colectomy for cancer. (unipd.it)
  • Immunohistochemical studies, through co-localization with ?SMA, demonstrated a massive presence of myofibroblasts in the mucosa of patients with Crohn's disease, that expressed TAK1 and its phosphorylated form, mainly in the periglandular region. (unipd.it)
  • To assess whether TAK1 can be used as an early marker of fibrogenetic process in Crohn's disease, we correlated its expression in a population of patients with Crohn's disease in remission and without clinical signs of stenosis, with markers of fibrosis. (unipd.it)
  • induced fibrogenesis process in Crohn's disease and further studies might indicate whether it is a suitable therapeutic target as well as a prognostic tool. (unipd.it)

type 2 diabet

  • We have previously reported that ileal interposition (IT) surgery delays the onset of type 2 diabetes in UCD-T2DM rats and increases circulating bile acids, independently of effects on energy intake or body weight. (biomedsearch.com)
  • Findings from the study, published online in the journal Gastroenterology, should help researchers identify strategies for preventing and treating type 2 diabetes, a chronic condition in which the body is unable to properly metabolize sugar and fat, leading to serious complications including heart disease, blindness and kidney failure. (ucdavis.edu)
  • In such cases, obesity is not just a weight issue but also a life-threatening health problem that often leads to type 2 diabetes, heart disease and sleep apnea. (ucdavis.edu)
  • To test the hypothesis, the researchers carried out a surgical procedure known as ileal interposition in a line of rats that were predisposed to obesity and type 2 diabetes. (ucdavis.edu)
  • The pathology of type 2 diabetes in these animals is more similar to type 2 diabetes in humans than other existing rodent models of the disease. (ucdavis.edu)


  • Thought you might appreciate this item(s) I saw at Inflammatory Bowel Diseases. (lww.com)
  • The complex interaction of genetic, microbial, and environmental factors may result in continuous activation of the mucosal immune system leading to inflammatory bowel disease (IBD). (physiology.org)
  • Chrohn's disease is a chronic inflammatory disease that can affect any part of the gastrointestinal tract from the mouth to the anus. (emedmd.com)


  • We hope that the method we have used here can be used to identify the genes involved in other diseases which are similarly complex, for example different cancers and diabetes. (news-medical.net)
  • In scrapie and prion diseases, the knowledge concerning genes involved in host response during the early infection period in the lymphoid tissues, still remains limited. (biomedcentral.com)
  • The three genes have not previously been associated with prion diseases and are interesting as they may reflect biological processes involved in the molecular pathogenesis of prion diseases. (biomedcentral.com)
  • A previous study by our group indicated an upregulation of prion mRNA expression in ileal PP follicles with accumulated PrP Sc [ 15 ], leading to the assumption that additional genes could be differentially expressed. (biomedcentral.com)
  • In the present study, the RNA arbitrarily primed PCR (RAP-PCR) and fingerprint approaches were chosen to screen for differentially expressed genes in the ileal PP of lambs eight months after experimental oral infection with scrapie. (biomedcentral.com)


  • Importantly, both datasets include detailed phenotypic information on individual patients, including the location and severity of intestinal inflammation, allowing the researchers to subdivide patients by disease presentation. (news-medical.net)
  • interestingly, their effects extended to people with extra-ileal as well as ileal inflammation. (news-medical.net)
  • Complications in other parts of the body may include inflammation of various parts of the eye, severe arthritis affecting various joints of the body, ankylosing spondylitis (an inflammation of the spine), skin disorders, liver disease, and gallstones. (emedmd.com)


  • Cells derived from fibrotic tissues maintained the disease phenotype in vitro and showed higher levels of TAK1 expression and greater activated status compared to control cells. (unipd.it)


  • Ileal Sodium/Bile Acid Cotransporter (Apical Sodium Dependent Bile Acid Transporter or ASBT or Sodium/Taurocholate Cotransporting Polypeptide Ileal or Solute Carrier Family 10 Member 2 or SLC10A2) - Ileal Sodium/Bile Acid Co-transporter is encoded by SLC10A2 gene. (medgadget.com)
  • In the present study, we have examined differential gene expression in ileal Peyer's patches and in laser microdissected follicles of sheep infected with scrapie. (biomedcentral.com)


  • The aim of treatment is to bring about long-term remission of the disease. (emedmd.com)
  • Once the disease is in remission, normal feeding can be resumed and the dose of corticosteroids reduced. (emedmd.com)


  • The latest report Ileal SodiumBile Acid Cotransporter - Pipeline Review, H1 2017, outlays comprehensive information on the Ileal Sodium/Bile Acid Cotransporter (Apical Sodium Dependent Bile Acid Transporter or ASBT or Sodium/Taurocholate Cotransporting Polypeptide Ileal or Solute Carrier Family 10 Member 2 or SLC10A2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (medgadget.com)


  • It is possible that the disease is caused by an abnormal immune response to an antigen (foreign protein). (emedmd.com)


  • Surgical treatment to remove damaged sections of the intestine is avoided whenever possible because the disease may recur in other parts. (emedmd.com)
  • In the included studies, the bariatric surgical procedures were Roux-en-Y gastric bypass, laparoscopic adjustable gastric banding, gastroplasty, sleeve gastrectomy, bilio-intestinal bypass, vertical banded gastroplasty and biliopancreatic diversion. (york.ac.uk)
  • The most commonly performed surgical procedure, known as Roux-en-Y gastric bypass surgery, limits the amount of food the stomach can hold and reroutes the digestive tract, resulting in changes in intestinal function and hormones produced by the gastrointestinal tract. (ucdavis.edu)


  • The disease causes spasms of abdominal pain, diarrhoea and chronic sickness, loss of appetite, anaemia, and weight loss. (emedmd.com)


  • The ileal interposition procedure involves relocating a short portion of the small intestine known as the ileum further forward in the intestinal tract. (ucdavis.edu)


  • The ileal PP and GALT are interesting in relation to prion diseases since these tissues represent the first site for accumulation of PrP Sc . (biomedcentral.com)


  • These patients often have IgE-negative disease as determined by skin testing or in vitro assay. (springer.com)


  • To evaluate the effect of weight loss after bariatric surgery on liver histopathological aspects of non-alcoholic fatty liver disease. (york.ac.uk)


  • Prion diseases or transmissible spongiform encephalopathies (TSEs), constitute a group of fatal neurodegenerative diseases that occur in a variety of species including sheep (scrapie), cattle (bovine spongiform encephalopathy (BSE)) and humans (e.g. (biomedcentral.com)


  • and the American National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which includes 813 patients with CD and 947 ethnically matched controls. (news-medical.net)
  • These patients had non-IgE-mediated disease as all 12 patients had negative results on immediate-type skin testing and negative results on IgE radioallergosorbent tests (RASTs). (springer.com)
  • Studies that included patients who had a jejuno-ileal bypass were excluded. (york.ac.uk)


  • This guideline was previously called neurological disease: management of lower urinary tract dysfunction in neurological disease. (nice.org.uk)


  • In elderly people, it is more common for the disease to affect the rectum and cause rectal bleeding. (emedmd.com)
  • This guideline covers assessing and managing urinary incontinence in children, young people and adults with neurological disease. (nice.org.uk)


  • Furthermore, this report also reviews key players involved in Ileal Sodium/Bile Acid Cotransporter (Apical Sodium Dependent Bile Acid Transporter or ASBT or Sodium/Taurocholate Cotransporting Polypeptide Ileal or Solute Carrier Family 10 Member 2 or SLC10A2) targeted therapeutics development with respective active and dormant or discontinued projects. (medgadget.com)