Hemosiderin is an iron-containing pigment that originates from the breakdown of hemoglobin and accumulates in tissues, primarily in macrophages, as a result of various pathological conditions such as hemorrhage, inflammation, or certain storage diseases.
Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.
The application of pathology to questions of law.
A genus of the order Sirenia characterized by a notched tail, the presence of nasal bones and a long nasal cavity, and large columnar teeth lacking enamel. Dugongs inhabit the coastal waters of the Indian Ocean, Red Sea, and the Malay Archipelago. (From Scott, Concise Encyclopedia Biology, 1996)
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.
Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
I'm sorry for any confusion, but "Venezuela" is a country in South America and not a medical term or concept. Therefore, it doesn't have a medical definition.
Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Idiopathic pulmonary haemosiderosis. Epidemiology, pathogenic aspects and diagnosis. (1/132)

Idiopathic pulmonary haemosiderosis (IPH) is a rare clinical entity characterized by recurrent episodes of diffuse alveolar haemorrhage, often presenting with haemoptysis. Many patients have iron deficiency anaemia due to deposition of haemosiderin iron in the alveoli, and eventually develop moderate pulmonary fibrosis. Typically, intensive search for an aetiology ends up negative. There is no evidence of pulmonary vasculitis or capillaritis. The aetiology is obscure, but may be an immunological or toxic mechanism causing a defect in the basement membrane of the pulmonary capillary. IPH affects both children and adults. During an acute episode, a chest X-ray demonstrates bilateral, alveolar infiltrates. Sputum examination discloses haemosiderin-laden alveolar macrophages. Diagnosis is established by lung biopsy (fiber-optic or thoracoscopic), showing large numbers of haemosiderin-laden macrophages in the alveoli and without evidence of capillaritis or deposition of immunoglobulins. Corticosteroids and/or immunosuppressive drugs may be effective during an acute bleeding episode, and may in some patients improve symptoms and prognosis on the long-term, but the response to treatment displays great interindividual variation.  (+info)

Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. (2/132)

BACKGROUND AND PURPOSE: Patients with spontaneous intracerebral hemorrhage (ICH) frequently have small areas of signal loss on gradient-echo T2*-weighted MR images, which have been suggested to represent remnants of previous microbleeds. Our aim was to provide histopathologic support for this assumption and to clarify whether the presence and location of microbleeds were associated with microangiopathy. METHODS: We performed MR imaging and correlative histopathologic examination in 11 formalin-fixed brains of patients who had died of an ICH (age range, 45-90 years). RESULTS: Focal areas of signal loss on MR images were noted in seven brains. They were seen in a corticosubcortical location in six brains, in the basal ganglia/thalami in five, and infratentorially in three specimens. Histopathologic examination showed focal hemosiderin deposition in 21 of 34 areas of MR signal loss. No other corresponding abnormalities were found; however, hemosiderin deposits were noted without MR signal changes in two brains. All specimens with MR foci of signal loss showed moderate to severe fibrohyalinosis, and there was additional evidence of amyloid angiopathy in two of those brains. CONCLUSION: Small areas of signal loss on gradient echo T2*-weighted images indicate previous extravasation of blood and are related to bleeding-prone microangiopathy of different origins.  (+info)

Alveolar haemorrhage in a case of high altitude pulmonary oedema. (3/132)

A case of high altitude pulmonary oedema (HAPE) in a climber who made a rapid ascent on Mt McKinley (Denali), Alaska is described. The bronchoalveolar lavage (BAL) fluid contained increased numbers of red blood cells and an abundance of haemosiderin laden macrophages consistent with alveolar haemorrhage. The timing of this finding indicates that alveolar haemorrhage began early during the ascent, well before the onset of symptoms. Although evidence of alveolar haemorrhage has been reported at necropsy in individuals dying of HAPE, previous reports have not shown the same abundance of haemosiderin laden macrophages in the BAL fluid. These findings suggest that alveolar haemorrhage is an early event in HAPE.  (+info)

Anthracycline cardiotoxicity in a black rhinoceros (Diceros bicornis): evidence for impaired antioxidant capacity compounded by iron overload. (4/132)

Two weeks before dying of congestive heart failure, a juvenile black rhinoceros (Diceros bicornis minor) received a single low dose of doxorubicin as part of combination chemotherapy for acute lymphoblastic leukemia. Diffuse hemosiderosis was present at necropsy in a pattern indicative of dietary iron overload, but unique iron-positive degenerative lesions were found in isolated myocardiocytes. Serum analyses revealed hyperferremia, 87% transferrin saturation, and 5- to 10-fold elevations in ferritin concentration, reflecting markedly increased tissue iron stores. Since both toxic and therapeutic effects of anthracyclines are mediated by formation of reactive free radicals via iron-catalyzed reactions, these observations suggest that iron overload may have enhanced myocardial susceptibility to cardiotoxic effects of doxorubicin. Impairments in other myocardial antioxidant defenses, such as deficiencies in catalase and glutathione S-transferase that are known to exist in rhinoceros erythrocytes, may have been underlying factors contributing to an inherent sensitivity of rhinoceros tissues to oxidant-induced injury.  (+info)

Low-frequency low-field magnetic susceptibility of ferritin and hemosiderin. (5/132)

Low-frequency low-field magnetic susceptibility measurements were made on four samples of mammalian tissue iron oxide deposits. The samples comprised: (1) horse spleen ferritin; (2) dugong liver hemosiderin; (3) thalassemic human spleen ferritin; and (4) crude thalassemic human spleen hemosiderin. These samples were chosen because Mossbauer spectroscopic measurements on the samples indicated that they exemplified the variation in magnetic and mineral structure found in mammalian tissue iron oxide deposits. The AC-magnetic susceptometry yielded information on the magnetization kinetics of the four samples indicating samples 1, 2, and 3 to be superparamagnetic with values of around 10(11) s(-1) for the pre-exponential frequency factor in the Neel-Arrhenius equation and values for characteristic magnetic anisotropy energy barriers in the range 250-400 K. Sample 4 was indicated to be paramagnetic at all temperatures above 1.3 K. The AC-magnetic susceptometry data also indicated a larger magnetic anisotropy energy distribution in the dugong liver sample compared with samples 1 and 3 in agreement with previous Mossbauer spectroscopic data on these samples. At temperatures below 200 K, samples 1-3 exhibited Curie-Weiss law behavior, indicating weak particle-particle interactions tending to favor antiparallel alignment of the particle magnetic moments. These interactions were strongest for the dugong liver hemosiderin, possibly reflecting the smaller separation between mineral particles in this sample. This is the first magnetic susceptometry study of hemosiderin iron deposits and demonstrates that the AC-magnetic susceptometry technique is a fast and informative method of studying such tissue iron oxide deposits.  (+info)

Benign transport of breast epithelium into axillary lymph nodes after biopsy. (6/132)

The most important prognostic indicator of distant metastasis in breast cancer is histologic documentation of axillary lymph node metastasis. Controversy exists about the importance of micrometastases (< 0.2 cm), and current pathology practice includes a careful search for their presence. We describe the histologic findings in a series of axillary lymph node dissections taken approximately 2 weeks after breast biopsy. Each case has limited presence of epithelial cells in the subcapsular sinus of a draining lymph node that we attribute to mechanical transport of tumor and/or normal breast epithelium secondary to the previous surgical or needle manipulation. These cells were accompanied by hemosiderin-laden macrophages and damaged RBCs. While the clinical implication of these findings is unknown, we believe that it will be of no clinical significance and have no untoward prognostic effect.  (+info)

Iron overload and kidney lysosomes. (7/132)

Iron overload has been associated with damage of the liver and other organs of patients with primary or secondary increased iron load. In order to study the effect of iron overload on the pathophysiology of kidney lysosomes, experimentally induced iron overload models were employed. Iron overload was achieved through intraperitoneal injections of Fe-dextran (Imferon) in male rats, at different final iron concentrations (825 and 1650 mg/kg, single and double dose groups respectively). Controls were injected with dextran following a similar protocol. The animals were killed at different time points after the last injection. Subcellular fractionation studies of kidney homogenates were carried out by differential centrifugation and density gradient centrifugation. The kidney iron load was increased with both doses. Iron appeared to accumulate mainly in the lysosomes, bringing about distinct changes in the behaviour of the organelles as judged by subcellular fractionation studies. Lysosomes became more fragile and showed increased density. The extent of the above changes seemed to correlate with the extent and duration of iron accumulation and could be reversed when the iron load was reduced.  (+info)

Ferritin iron absorption in man. (8/132)

The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects with moderate iron deficiency and 5.7 percent in subjects with marked iron deficiency. The administration of this iron compound with vegetals in a meal showed distinctly lower absorption values than the absorption from either maize, wheat, or soybean. Ferritin iron absorption was also different from that of ferric chloride when they were administered together as a drink or mixed with maize or liver. The iron absorption from ferritin was markedly increased when it was administered with either meat or liver, but it did not reach the absorption level of these foods. It is still to be elucidated whether the difference in iron absorption between ferritin and vegetable foods administered together reflect that this iron is incompletely miscible with a nonheme iron pool or that it really forms a third iron pool.  (+info)

Hemosiderin is a golden-brown pigment that consists of iron-containing protein complexes called ferritin and ferrikinase. It is insoluble in water and forms as a result of the breakdown of hemoglobin in the reticuloendothelial system, primarily in macrophages. Hemosiderin deposits can be found in various tissues and organs, such as the spleen, liver, and brain, under conditions of increased red blood cell destruction or impaired iron metabolism. These deposits are often associated with diseases such as hemochromatosis, thalassemia, and chronic inflammation.

Hemosiderosis is a medical condition characterized by the abnormal accumulation of hemosiderin, an iron-containing protein, in various organs and tissues of the body. Hemosiderin is derived from the breakdown of hemoglobin, which is the oxygen-carrying protein in red blood cells. When there is excessive breakdown of red blood cells or impaired clearance of hemosiderin, it can lead to its accumulation in organs such as the liver, spleen, and lungs.

Hemosiderosis can be classified into two types: primary and secondary. Primary hemosiderosis is a rare condition that is caused by genetic disorders affecting red blood cells, while secondary hemosiderosis is more common and is associated with various conditions that cause excessive breakdown of red blood cells or chronic inflammation. These conditions include hemolytic anemias, repeated blood transfusions, liver diseases, infections, and certain autoimmune disorders.

The accumulation of hemosiderin can lead to tissue damage and organ dysfunction, particularly in the lungs, where it can cause pulmonary fibrosis, and in the heart, where it can lead to heart failure. Hemosiderosis is typically diagnosed through a combination of medical history, physical examination, and laboratory tests, including blood tests and imaging studies such as chest X-rays or MRI scans. Treatment of hemosiderosis depends on the underlying cause and may include medications, blood transfusions, or supportive care to manage symptoms and prevent complications.

Siderosis is a medical condition characterized by the abnormal accumulation of iron in various tissues and organs, most commonly in the lungs. This occurs due to the repeated inhalation of iron-containing dusts or fumes, which can result from certain industrial processes such as welding, mining, or smelting.

In the lungs, this iron deposit can lead to inflammation and fibrosis, potentially causing symptoms like coughing, shortness of breath, and decreased lung function. It is important to note that siderosis itself is not contagious or cancerous, but there may be an increased risk for lung cancer in individuals with severe and prolonged exposure to iron-containing particles.

While siderosis is generally non-reversible, the progression of symptoms can often be managed through medical interventions and environmental modifications to reduce further exposure to iron-containing dusts or fumes.

Forensic pathology is a subspecialty of pathology that focuses on determining the cause and manner of death by examining a corpse. It involves applying scientific knowledge and techniques to investigate criminal or suspicious deaths, often in conjunction with law enforcement agencies. A forensic pathologist performs autopsies (postmortem examinations) to evaluate internal and external injuries, diseases, and other conditions that may have contributed to the individual's death. They also collect evidence such as tissue samples, which can be used for toxicological, microbiological, or histological analysis. The information gathered by forensic pathologists is crucial in helping to establish the facts surrounding a person's death and assisting legal proceedings.

A dugong is a large marine mammal that belongs to the family Dugongidae. Its scientific name is Dugong dugon. It is also known as the sea cow because of its habit of feeding on seagrasses. Dugongs are found in warm coastal waters of the Indian and Pacific Oceans, ranging from East Africa to Vanuatu in the west and from Japan to Australia in the east. They can grow up to 3 meters in length and weigh between 200-500 kilograms.

Dugongs have a streamlined body with a flat, paddle-like tail and two flippers. Their skin is thick and wrinkled, and they are usually gray or brownish-gray in color. Dugongs have a unique feeding apparatus that allows them to graze on seagrasses, which include specialized lips and teeth.

Dugongs are social animals that live in small groups called herds. They communicate with each other using a variety of sounds, including clicks, chirps, and whistles. Dugongs have a long lifespan, with some individuals living up to 70 years or more.

Unfortunately, dugongs are threatened by various human activities, such as hunting, habitat loss, and entanglement in fishing nets. They are currently listed as vulnerable on the International Union for Conservation of Nature (IUCN) Red List of Threatened Species.

A cavernous hemangioma in the central nervous system (CNS) refers to a type of benign vascular tumor that is made up of dilated and thin-walled blood vessels. These tumors are called "cavernous" because they are filled with blood-filled sacs or "caverns."

When these hemangiomas occur in the CNS, which includes the brain and spinal cord, they can cause various neurological symptoms depending on their size and location. Small hemangiomas may not cause any symptoms at all, while larger ones can cause seizures, headaches, weakness, or sensory changes.

Cavernous hemangiomas in the CNS are typically congenital, meaning that they are present at birth. However, they may not become symptomatic until later in life. Treatment options for cavernous hemangiomas in the CNS include observation, surgery, or radiation therapy, depending on the size, location, and symptoms caused by the tumor.

Ferritin is a protein in iron-metabolizing cells that stores iron in a water-soluble form. It is found inside the cells (intracellular) and is released into the bloodstream when the cells break down or die. Measuring the level of ferritin in the blood can help determine the amount of iron stored in the body. High levels of ferritin may indicate hemochromatosis, inflammation, liver disease, or other conditions. Low levels of ferritin may indicate anemia, iron deficiency, or other conditions.

Biological pigments are substances produced by living organisms that absorb certain wavelengths of light and reflect others, resulting in the perception of color. These pigments play crucial roles in various biological processes such as photosynthesis, vision, and protection against harmful radiation. Some examples of biological pigments include melanin, hemoglobin, chlorophyll, carotenoids, and flavonoids.

Melanin is a pigment responsible for the color of skin, hair, and eyes in animals, including humans. Hemoglobin is a protein found in red blood cells that contains a porphyrin ring with an iron atom at its center, which gives blood its red color and facilitates oxygen transport. Chlorophyll is a green pigment found in plants, algae, and some bacteria that absorbs light during photosynthesis to convert carbon dioxide and water into glucose and oxygen. Carotenoids are orange, yellow, or red pigments found in fruits, vegetables, and some animals that protect against oxidative stress and help maintain membrane fluidity. Flavonoids are a class of plant pigments with antioxidant properties that have been linked to various health benefits.

In the context of medicine, iron is an essential micromineral and key component of various proteins and enzymes. It plays a crucial role in oxygen transport, DNA synthesis, and energy production within the body. Iron exists in two main forms: heme and non-heme. Heme iron is derived from hemoglobin and myoglobin in animal products, while non-heme iron comes from plant sources and supplements.

The recommended daily allowance (RDA) for iron varies depending on age, sex, and life stage:

* For men aged 19-50 years, the RDA is 8 mg/day
* For women aged 19-50 years, the RDA is 18 mg/day
* During pregnancy, the RDA increases to 27 mg/day
* During lactation, the RDA for breastfeeding mothers is 9 mg/day

Iron deficiency can lead to anemia, characterized by fatigue, weakness, and shortness of breath. Excessive iron intake may result in iron overload, causing damage to organs such as the liver and heart. Balanced iron levels are essential for maintaining optimal health.

I'm sorry for any confusion, but "Venezuela" is not a medical term. It is the name of a country located in South America, known officially as the Bolivarian Republic of Venezuela. If you have any questions about medical terms or health-related topics, I would be happy to try and help answer those for you!

"Iron radioisotopes" refer to specific forms of the element iron that have unstable nuclei and emit radiation. These isotopes are often used in medical imaging and treatment procedures due to their ability to be detected by specialized equipment. Common iron radioisotopes include Iron-52, Iron-55, Iron-59, and Iron-60. They can be used as tracers to study the distribution, metabolism, or excretion of iron in the body, or for targeted radiation therapy in conditions such as cancer.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

... can be identified histologically with Perls' Prussian blue stain; iron in hemosiderin turns blue to black when ... The body then traps the released iron and stores it as hemosiderin in tissues. Hemosiderin is also generated from the abnormal ... producing hemosiderin and biliverdin. Excessive systemic accumulations of hemosiderin may occur in macrophages in the liver, ... Hemosiderin can accumulate in different organs in various diseases. Iron is required by many of the chemical reactions (i.e., ...
... is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, ...
Stainable marrow hemosiderin is increased.[citation needed] Sideroblastic anemia is typically divided into subtypes based on ...
Hemosiderin collects in the skin and is slowly removed after bruising; hemosiderin may remain in some conditions such as stasis ... Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of ... Hemosiderin in the kidneys has been associated with marked hemolysis and a rare blood disorder called paroxysmal nocturnal ... Hemosiderin may deposit in diseases associated with iron overload. These diseases are typically diseases in which chronic blood ...
There is erythrocyte extravasation and hemosiderin pigmentation. Micrograph of tumor stage. Well-circumscribed spindle-cell ...
A siderophage is a hemosiderin-containing macrophage. Heart failure cells are siderophages generated in the alveoli of the ... Alveolar macrophages (dust cells) engulf the red blood cells, and become engorged with brownish hemosiderin. In chronic ...
Pathologists have identified hemosiderin pigments that are considered unique to the GOC. The discovery of this pigment can be ... AbdullGaffar, Badr; Koilelat, Mohamed (May 2017). "Glandular Odontogenic Cyst: The Value of Intraepithelial Hemosiderin". ... AbdullGaffar, Badr; Koilelat, Mohamed (May 2017). "Glandular Odontogenic Cyst: The Value of Intraepithelial Hemosiderin". ...
The tubule cells of the proximal tubule become damaged, slough off with the hemosiderin and are excreted into the urine, ... haemosiderinuria) is the presence of hemosiderin in urine. It is often the result of chronic intravascular hemolysis, in which ... Hemoglobinuria is another indicator of intravascular hemolysis, but disappears more quickly than hemosiderin, which can remain ... where the iron portion is removed and stored in ferritin or hemosiderin. ...
... staining, highlighting the hemosiderin pigment as blue. Prussian blue stain Engineer's blue, Prussian blue in an ... Histopathology of the liver, showing a Kupffer cells with significant hemosiderin deposition next to a hepatocyte with ...
It can detect hemosiderin deposition in joints as seen in arthropathy by hemophilia, as well as pigmented villonodular ... T2*-weighted sequences are used to detect deoxygenated hemoglobin, methemoglobin, or hemosiderin in lesions and tissues. ... hemorrhages and hemosiderin deposits become hypointense. T2*-weighted imaging is built from the basic physics of magnetic ...
The staining is due to the presence of hemosiderin. The staining is usually most intense in the dorso-caudal region of the left ... The end product of the digestion of the red blood cells is an iron-storage complex known as hemosiderin. Bronchoalveolar lavage ... Doucet, Michele Y.; Viel, Laurent (May 2002). "Alveolar Macrophage Graded Hemosiderin Score from Bronchoalveolar Lavage in ... hemosiderin accumulation, fibrosis, and bronchial angiogenesis. While all horses undertaking intense exercise experience some ...
In such cases adjacent hemorrhage and hemosiderin deposition is common. Collagen type IV stain will have a strong continuous ...
Hemosiderin pigment deposition due to vessel rupture may be observed. The GLUT-1 histochemical marker can be helpful in ...
The characteristic brown coloration results from hemosiderin deposition into the osteolytic cysts. Hemosiderin deposition is ... 1991). "Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation". Journal of Computer ...
Long-standing lesions may show hemosiderin-laden macrophages and calcifications. The most common form of treatment is having ...
Death of heart failure cells in their journey back to lung tissue with subsequent hemosiderin release leads to lung fibrosis. ... Rupture of congested capillaries leads to release of hemosiderin from damaged red blood cells. When alveolar macrophages engulf ... Brown induration is fibrosis and hemosiderin pigmentation of the lungs due to long standing pulmonary congestion (chronic ... hemosiderin they are called heart failure cells. ...
Iron in ferritin or hemosiderin can be extracted for release by the RE cells, although hemosiderin is less readily available. ... Aggregated ferritin transforms into a toxic form of iron called hemosiderin. Ferritin is a globular protein complex consisting ... As ferritin accumulates within cells of the reticuloendothelial system, protein aggregates are formed as hemosiderin. ... iron is stored in a protein complex as ferritin or the related complex hemosiderin. Apoferritin binds to free ferrous iron and ...
In proximal tubules, the iron is extracted and stored as hemosiderin. (Long-term hemoglobinuria is associated with substantial ... The phenomenon tells that the detection of hemosiderin in urine is indicative of either ongoing or recent intravascular ... deposition of hemosiderin in proximal tubule (excessive accumulation of hemosiderin in proximal tubule), Fanconi syndrome ( ... by excessive hemoglobin and/or met-hemoglobin filtered through the renal glomerulus as well as the loss of hemosiderin-laden ...
Another pigment in smoker's macrophage is hemosiderin which is involved in iron homoeostasis. Hemosiderin-laden pigmented ... Hemosiderin is the iron storage in smoker's macrophage rather than ferritin. It is formed during hemorrhage or abnormal ... The level of hemosiderin-laden macrophage is also associated with pulmonary hemodynamics parameters which is used to evaluate ... "Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary ...
Another study looked at the brains of people with HACE several months after their recovery; it showed hemosiderin deposits in ...
... most of the iron is stored as hemosiderin. Clearance of heparin via heparinases The various cell types of the mononuclear ...
Hemosiderosis is hemosiderin deposition within cells, while hemochromatosis is hemosiderin within cells and interstitium. ... which mainly occurs in the form of the iron-storage complex hemosiderin. Sometimes, the simpler term siderosis is used instead ...
Near the borders of the lesion, deposits of hemosiderin and hemorrhage is often found. In 50% of cases, ulcerations are present ...
All features of endometriosis are present (endometrial glands, endometrial stroma and hemosiderin-laden macrophages). The most ... mainly hemosiderin deposits Immunohistochemistry has been found to be useful in diagnosing endometriosis as stromal cells have ...
Phase images were used to enhance the effect of the local hemosiderin build-up. An example phase image (right) with yet higher ...
Another aspect is that iron, which composes hemosiderin, emits light of several wavelengths when stimulated. In translumination ...
Iron is also stored as a pigment called hemosiderin, which is an ill-defined deposit of protein and iron, created by ... If systemic iron overload is corrected, over time the hemosiderin is slowly resorbed by the macrophages. Human iron homeostasis ... Dysfunctional ferritin may accumulate as hemosiderin, which can be problematic in cases of iron overload. The ferritin storage ...
Iron is also stored as a pigment called hemosiderin, which is an ill-defined deposit of protein and iron, created by ... If systemic iron overload is corrected, over time the hemosiderin is slowly resorbed by the macrophages. Human iron homeostasis ... Dysfunctional ferritin may accumulate as hemosiderin, which can be problematic in cases of iron overload. The ferritin storage ...
Hämosiderin-Pigmentirung der Leber und Lebercirrhose, 1896 - Hemosiderin-pigmentation involving the liver and liver cirrhosis. ...
... and hemosiderin. A granulomatous reaction, induced by the exudate, may be seen with the retina. Portions of the retina may ...
Hemosiderin can be identified histologically with Perls Prussian blue stain; iron in hemosiderin turns blue to black when ... The body then traps the released iron and stores it as hemosiderin in tissues. Hemosiderin is also generated from the abnormal ... producing hemosiderin and biliverdin. Excessive systemic accumulations of hemosiderin may occur in macrophages in the liver, ... Hemosiderin can accumulate in different organs in various diseases. Iron is required by many of the chemical reactions (i.e., ...
Its the presence of iron that gives hemosiderin a rusty, brownish-yellow color. Over time, areas of hemosiderin staining can ... For hemosiderin staining, a device known as a Q-switched laser is often used. This is the kind of laser used in tattoo removal ... Hemosiderin staining occurs when the smallest blood vessels, known as capillaries, begin to leak. This can be due to a wound, a ... In most cases, hemosiderin staining that has been caused by physical injury will gradually disappear as the damaged tissues ...
Hemosiderin. Hemorrhage or hemosiderin in or at the cranial or caudal margin of ependymomas is a common imaging finding. T2- ... 15] This hemosiderin cap is fairly suggestive of ependymomas. [16] With filum ependymomas, hemorrhagic products may be seen ... T2-weighted sagittal image demonstrates the hemosiderin and caudal cyst associated with the tumor. View Media Gallery ... Astrocytomas are less prone to hemorrhage and infrequently result in a hemosiderin cap. More often, astrocytomas are eccentric ...
Book online Hemosiderin (Urine) at home ✔️ Trusted Lab Partners ✔️ Discounts ✔️ Home Sampling ... What is this test?Hemosiderin urine is a laboratory test used to detect the presence of hemosiderin in urine. Hemosiderin is a ... What is hemosiderin?. Hemosiderin is a protein that stores iron derived from the destruction of red blood cells and disturbed ...
Learn how to manage skin discoloration with hemosiderin staining, including treatments and lifestyle changes. ... Hemosiderin staining is a common side effect of bruising. ... JamesPain Managementhemosiderin staining after bruise Source : ... Hemosiderin staining occurs when the body is unable to clear the hemosiderin, a form of iron, from the area of the bruise. ... Hemosiderin staining after a bruise is a common skin discoloration that can be difficult to manage. Hemosiderin is a protein ...
This is a symptom known as hemosiderin staining, and it may indicate a problem with vein health. ... What Is Hemosiderin Staining?. Hemosiderin staining occurs when red blood cells leak through the veins. As iron and other by- ... What Causes Hemosiderin Staining?. Hemosiderin staining could happen for several reasons.. Chronic vein disease. Chronic vein ... How to Treat Hemosiderin Staining - Curing the Condition. Treating hemosiderin staining is not only about getting rid of the ...
There is no one-size-fits-all answer to the best cream for hemosiderin staining, as it can vary depending on the individual and ...
Intracranial hemorrhage (ie, the pathological accumulation of blood within the cranial vault) may occur within brain parenchyma or the surrounding meningeal spaces. Hemorrhage within the meninges or the associated potential spaces, including epidural hematoma, subdural hematoma, and subarachnoid hemorrhage, is covered in detail in other artic...
... perivascular hemosiderin (defined as hemosiderin in perivascular spaces as opposed to microhemorrhage in which hemosiderin is ... 4). Two CBAs showed only perivascular hemosiderin. Almost all cases had adjacent vessels showing perivascular hemosiderin, and ... and for perivascular hemosiderin 0 = absent, 1 = ,3 hemosiderin granule deposits, 2 = 3-5, and 3 = ,5 [37]. ... A CBA forming a fibrous ball with rare hemosiderin deposits (arrow). B On Aβ40 immunohistochemistry the same CBA (arrow) is in ...
... or large to assess the burden of hemosiderin. To date, there is no known method to assess or quantify hemosiderin concentration ... Hemosiderin deposition in hypertrophic synovium is a hallmark of progressive hemophilic arthropathy and accumulates with joint ... Conventional quantification of hemosiderin uses semi-quantitative MRI scores, assigning grades of small, moderate, ... Ultrashort Echo Time Chemical Shift Quantitative Susceptibility Mapping (UTE-CS-QSM) for Hemosiderin Assessment in Hemophilic ...
DAD, diffuse alveolar damage; HLM, hemosiderin-laden macrophages; IHC, immunohistochemistry; MA, mucus aspiration; NA, not ...
... given an increase in lung hemosiderin scores, an increase in liver hemosiderin scores was also observed. Similarly, a marked ... The Significance of Hemosiderin Deposition in the Lungs and Organs of the Mononucleated Macrophage Resorption System in Infants ... Hemosiderin deposition is not often recognized on routine examination with hematoxylin and eosin staining; however, iron stains ... The probability of spleen hemosiderin-positive cases belonging to the age group under 6 months was found to be 4.3 times ...
A brown-to-slate-gray discoloration may occur as a result of hemosiderin deposition in association with iron overload from ... The pigmentary alteration results from retained urochromes and hemosiderin deposition. The large bullae are consistent with ... The pigmentary alteration results from retained urochromes and hemosiderin deposition. The large bullae are consistent with ... The pigmentary alteration results from retained urochromes and hemosiderin deposition. The large bullae are consistent with ...
Hemoglobin, hemosiderin, biliverden and Hematoidin. List endogenous pigments that are nonhematogenous and lipidic. Lipofuscin ... Nuclei and hemofuchsin = Bright Red Hemosiderin = Blue Background = Pink. Prussian Blue Stain. ...
Categories: Hemosiderin Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 1 ...
Extensive hemosiderin-laden macrophages were present in lung tissue of nine (5%) infants -- a finding indicating major ... Pathologic lung specimens were sectioned, stained with Prussian blue, and screened for the presence of hemo-siderin. ... Macrophages require approximately 48 hours to convert the iron of the ingested erythrocytes into hemosiderin; therefore, the ... association of environmental factors with pulmonary hemorrhage/hemosiderosis and the presence of extensive hemosiderin-laden ...
This model can also be used as a teaching tool and practice leg for clinicians learning about/practicing compression wrapping. An Optional Display Stand is available which permits Vinnie to pivot from above the knee, providing a realistic experience in supporting the leg while practicing compression wrapping, dressing changes or identifying conditions. Shipping Weight is 9 lbs. An Optional Carry Case is also available under SKU A-105194 (MPN 0556).. *Some of the conditions represented on this model may appear different on individual patients, yet still be considered the same condition. The representations of the conditions we have chosen to display are based on feedback from wound care professionals ...
Cerebrovascular accidents (CVA) are one of the major causes of disability among human adults. Previously considered uncommon, CVA are increasingly recognized in dogs or cats with the advances of neuro-imaging. Most types of CVA that are seen in humans have been documented in dogs.1 Recovery from cerebrovascular disorders in animals is probably more spectacular than in humans because animals have a less prominent pyramidal system.2 A stroke is a suddenly developing focal neurological deficit resulting from a cerebrovascular accident.3 The causes of strokes can be divided into two basic groups: (1) obstruction of the blood vessels leading to ischemia, and (2) rupture of blood vessel walls leading to hemorrhage.4. The central nervous system (CNS) requires a continuous supply of glucose and oxygen to sustain its high expenditure of energy. The transportation of these fuel molecules requires sufficient blood flow through a cerebral vasculature with adequate capacity. In the dog, blood supply to the ...
The most common pigment is hemosiderin (Figure 1). Pigmentation of urothelium has been observed with administered dye compounds ... Therefore, it is recommended that a diagnosis of "pigment" (as opposed to diagnosing the type of pigment, e.g., hemosiderin or ... The most common pigment is hemosiderin (Figure 1. ). Pigmentation of urothelium has been observed with administered dye ... Pigment-a focal area of hemosiderin from a female F344/N rat in a chronic study. ...
Common Questions, Quick Answers on Stool and Urine Color Changes
In addition, subungual hemoglobin is not degraded in hemosiderin by the macrophage. Staining with Prussia blue favors a ... However, the difference between hemosiderin and melanin pigment in histopathology sometimes requires an ultra-structural ...
Hemosiderin Accumulation in Liver Decreases Iron Availability in Tachycardia-Induced Porcine Congestive Heart Failure Model. ...
It readily chelates iron from ferritin and hemosiderin but not readily from transferrin; it does not combine with the iron from ...
In this pattern cystic degeneration with hemosiderin-laden macrophages is present. There are also sheets of follicular cells ... and always associated with hemosiderin-laden macrophages and benign-appearing macrofollicle fragments. The spindle-shaped ...
Histological examination of the nodule revealed endometriosis with hemosiderin-loaded macrophages. This case is considered as ...
Ferritin and hemosiderin are present primarily in the liver, bone marrow, spleen, and skeletal muscles. Small amounts of ... but some is stored as hemosiderin. Iron is transported in blood by the protein transferrin. The total amount of iron in the ... and smaller amounts are stored as hemosiderin (Table 1). When long-term negative iron balance occurs, iron stores are depleted ... Hemosiderin 4 1 Transport protein Transferrin ,1 ,1 Functional compounds Hemoglobin 31 31 Myoglobin 4 4 Respiratory enzymes 2 2 ...
ARIA with hemosiderin deposition (ARIA-H), which includes cerebral hemorrhage and superficial siderosis, occurred in 17%. ...
  • Hemosiderin deposition in hypertrophic synovium is a hallmark of progressive hemophilic arthropathy and accumulates with joint bleeding. (ismrm.org)
  • however, iron stains may be helpful in the evaluation of hemosiderin deposition in infant autopsies. (uludag.edu.tr)
  • The pigmentary alteration results from retained urochromes and hemosiderin deposition. (medscape.com)
  • Monoclonal antibodies directed against aggregated forms of beta amyloid, including ADUHELM, can cause amyloid related imaging abnormalities (ARIA), characterized as ARIA with edema (ARIA-E) and ARIA with hemosiderin deposition (ARIA-H). ARIA is usually asymptomatic, although rarely serious and life-threatening events can occur. (nih.gov)
  • Splenic AgNP accumulation was greatest in red pulp and occurred with modestly reduced cellularity and elevated hemosiderin deposition. (cdc.gov)
  • This evokes venous hypertension, blood-brain barrier breakdown, hemosiderin deposition, and a secondary immune-mediated response with resultant demyelinating plaque. (ajnr.org)
  • Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. (wikipedia.org)
  • Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. (wikipedia.org)
  • Cellular iron is found as either ferritin or hemosiderin. (wikipedia.org)
  • Hemosiderin is an iron-storage protein that forms when ferritin, a primary iron-storage protein, becomes saturated with iron. (livingwithss.com)
  • When body iron stores increase above these relatively normal ratios, proportionally greater amounts of iron are stored in non-blood tissue in ferritin molecules or a complex called hemosiderin. (irondisorders.org)
  • As a hematoma ages, hemoglobin changes through several forms oxyhemoglobin, deoxyhemoglobin, and methemoglobin before the RBCs are broken down into ferritin and hemosiderin. (medscape.com)
  • Ferritin is water-soluble, while hemosiderin is water-insoluble. (medscape.com)
  • Ferritin in lysosomes is converted into hemosiderin upon partial degradation of its protein shell by lysosomal enzymes. (medscape.com)
  • Hemosiderin is most commonly found in macrophages and is especially abundant in situations following hemorrhage, suggesting that its formation may be related to phagocytosis of red blood cells and hemoglobin. (wikipedia.org)
  • Phagocytic cells (of the mononuclear phagocyte system) called macrophages engulf (phagocytose) the hemoglobin to degrade it, producing hemosiderin and biliverdin. (wikipedia.org)
  • Extensive hemosiderin-laden macrophages were present in lung tissue of nine (5%) infants -- a finding indicating major pulmonary hemorrhage preceding death. (cdc.gov)
  • The hyalinized stroma frequently contains hemosiderin-laden macrophages and inflammatory cells. (webpathology.com)
  • Melanomacrophage centers (MMCs) consist of macrophages, such as phagocytic cells and fragments, mainly erythrocytes and pigments, such as melanin, hemosiderin and lipofuscin, located in the reticuloendothelial liver tissue, kidney and pancreas ( Agius and Roberts, 2003 AGIUS, C. (scielo.br)
  • Dear Reader: You have described a condition known as "hemosiderin staining. (uclahealth.org)
  • Hemosiderin staining occurs when the smallest blood vessels, known as capillaries, begin to leak. (uclahealth.org)
  • Over time, areas of hemosiderin staining can change color and intensify, becoming dark brown or even black. (uclahealth.org)
  • In most cases, hemosiderin staining that has been caused by physical injury will gradually disappear as the damaged tissues heal. (uclahealth.org)
  • For hemosiderin staining, a device known as a Q-switched laser is often used. (uclahealth.org)
  • Hemosiderin staining after a bruise is a common skin discoloration that can be difficult to manage. (neuroseed.net)
  • Fortunately, there are a variety of treatments available to help reduce the appearance of hemosiderin staining. (neuroseed.net)
  • In this article, we will discuss the causes of hemosiderin staining, the available treatments, and how to prevent it from occurring in the future. (neuroseed.net)
  • Hemosiderin staining is a common skin discoloration that can occur after bruising. (neuroseed.net)
  • While hemosiderin staining is not dangerous, it can be unsightly and can cause distress for those affected. (neuroseed.net)
  • The first step in treating hemosiderin staining is to keep the affected area clean and dry. (neuroseed.net)
  • These products can help to reduce the appearance of hemosiderin staining by lightening the skin. (neuroseed.net)
  • In some cases, laser treatments may be recommended to reduce the appearance of hemosiderin staining. (neuroseed.net)
  • Sun exposure can cause further discoloration and can make the hemosiderin staining more noticeable. (neuroseed.net)
  • By following these tips, it is possible to reduce the appearance of hemosiderin staining after bruising. (neuroseed.net)
  • Hemosiderin staining is a common consequence of bruising and can be a source of distress for many individuals. (neuroseed.net)
  • It is important to understand the causes of hemosiderin staining and the strategies that can be used to prevent it. (neuroseed.net)
  • Hemosiderin staining occurs when the body is unable to clear the hemosiderin, a form of iron, from the area of the bruise. (neuroseed.net)
  • There are several factors that can contribute to hemosiderin staining. (neuroseed.net)
  • Genetics can also play a role, as some individuals are more prone to hemosiderin staining than others. (neuroseed.net)
  • Certain medications, such as anticoagulants, can also increase the risk of hemosiderin staining. (neuroseed.net)
  • Fortunately, there are several strategies that can be used to prevent hemosiderin staining. (neuroseed.net)
  • This can help reduce the severity of the bruise and reduce the risk of hemosiderin staining. (neuroseed.net)
  • Hemosiderin Staining - Why Your Legs Are Turning Brown? (astraveinvascular.com)
  • What Is Hemosiderin Staining? (astraveinvascular.com)
  • Hemosiderin staining occurs when red blood cells leak through the veins. (astraveinvascular.com)
  • Hemosiderin staining could happen for several reasons. (astraveinvascular.com)
  • Chronic vein disease is the primary cause of hemosiderin staining. (astraveinvascular.com)
  • If your hemosiderin staining is a side effect of some injury or other treatment, it will clear up on its own. (astraveinvascular.com)
  • Hemosiderin staining is more than a cosmetic issue. (astraveinvascular.com)
  • In some cases, sclerotherapy side effects cause hemosiderin staining as a result of iron deposits. (astraveinvascular.com)
  • Treating hemosiderin staining is not only about getting rid of the discoloration on the legs but the vein disease that is causing this condition. (astraveinvascular.com)
  • There is no one-size-fits-all answer to the best cream for hemosiderin staining, as it can vary depending on the individual and the severity of the staining. (blogarama.com)
  • With the exception of Prussian blue staining for hemosiderin, definitive pigment identification is often difficult in histologic sections, even with a battery of special stains. (nih.gov)
  • The iron within deposits of hemosiderin is very poorly available to supply iron when needed. (wikipedia.org)
  • In normal animals, hemosiderin deposits are small and commonly inapparent without special stains. (wikipedia.org)
  • After the major differential diagnoses were ruled out, this study demonstrated, that depending on the statistically assessed morphometric grounds, the presence of hemosiderin deposits in the liver and spleen were significantly higher in the age group under 6 months. (uludag.edu.tr)
  • The best diagnostic combination is: soft-tissue tumor near a joint or along a tendon sheath showing intermediate signal intensity on T1 and T2W images with hemosiderin deposits 3,5 . (radiopaedia.org)
  • Hemosiderin deposits and erythrocyte extravasation were found. (bvsalud.org)
  • Excessive accumulation of hemosiderin is usually detected within cells of the mononuclear phagocyte system (MPS) or occasionally within epithelial cells of the liver and kidney. (wikipedia.org)
  • In and of itself, the accumulation of hemosiderin is not a threat to health. (uclahealth.org)
  • In the liver, there were blood congestion in sinusoids, vacuolation of hepatocytes, hemosiderin accumulation, apoptosis and nuclear pyknosis. (scialert.net)
  • An accumulation of hemosiderin may contribute to oxidative stress and the formation of reactive oxygen species (ROS), which can cause damage to cells and contributes to the disorder's progression. (livingwithss.com)
  • Hemosiderin is a breakdown product of hemoglobin and its presence in urine determines disorders related to red blood cell destruction. (dawaai.pk)
  • When red blood cells break down, hemoglobin is stored as hemosiderin. (astraveinvascular.com)
  • To date, there is no known method to assess or quantify hemosiderin concentration within synovium due to the extremely short T2 values of this tissue. (ismrm.org)
  • This leads to the formation of a type of protein known as hemosiderin, which stores iron in the body. (uclahealth.org)
  • Hemosiderin is a protein that stores iron derived from the destruction of red blood cells and disturbed iron metabolism. (dawaai.pk)
  • Hemosiderin is a protein that is released from red blood cells when they break down. (neuroseed.net)
  • Another way in which iron can escape from hemosiderin is through the activity of certain enzymes that break down the protein complex and release iron. (livingwithss.com)
  • When the lymphatic system is unable to clear the hemosiderin, it accumulates in the area of the bruise and causes a yellow-brown discoloration of the skin. (neuroseed.net)
  • In many forms of cirrhosis, iron accumulates in the liver in the form of brown hemosiderin. (medprep.info)
  • Therefore, it is recommended that a diagnosis of "pigment" (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is more appropriate. (nih.gov)
  • We have shown that synovium in joints with hemophilic arthropathy demonstrates various susceptibility values, likely corresponding to different concentrations of hemosiderin. (ismrm.org)
  • A histochemical technique was used to identify hemosiderin in lung, liver and spleen specimens, which was correlated with other descriptive variables such as the reported cause of death, postmortem interval, trauma history, gender, and age. (uludag.edu.tr)
  • i.e., given an increase in lung hemosiderin scores, an increase in liver hemosiderin scores was also observed. (uludag.edu.tr)
  • Similarly, a marked positive correlation between spleen and liver hemosiderin scores (Spearman's rank correlation coefficient, rho=0.335, p=0.002) was observed. (uludag.edu.tr)
  • Hemosiderin is a byproduct of the breakdown of red blood cells and is normally cleared from the body through the lymphatic system. (neuroseed.net)
  • Discoloration of the lower legs is mainly caused by hemosiderin that indicates red blood cells are leaking through the veins, extending to further complications. (astraveinvascular.com)
  • Hemosiderin urine is a laboratory test used to detect the presence of hemosiderin in urine. (dawaai.pk)
  • Is hemosiderin present in the urine, normally? (dawaai.pk)
  • No, hemosiderin is not detected in urine of a healthy individual. (dawaai.pk)
  • Presence of hemosiderin in urine indicating red cell destruction. (dawaai.pk)
  • Hemosiderin not present in urine. (dawaai.pk)
  • Pigment-a focal area of hemosiderin from a female F344/N rat in a chronic study. (nih.gov)
  • It's the presence of iron that gives hemosiderin a rusty, brownish-yellow color. (uclahealth.org)
  • Hemosiderin can accumulate in different organs in various diseases. (wikipedia.org)
  • Hemosiderin may deposit in diseases associated with iron overload. (wikipedia.org)
  • The probability of spleen hemosiderin-positive cases belonging to the age group under 6 months was found to be 4.3 times greater than those who were hemosiderin-negative (95% confidence interval, 1.6-11.8). (uludag.edu.tr)
  • MRI appearance may include low to intermediate signal with low signal septa on T1W images, low to intermediate with low signal hemosiderin foci on T2W images and may be inhomogeneous on both. (radiopaedia.org)
  • The body then traps the released iron and stores it as hemosiderin in tissues. (wikipedia.org)
  • Age is a major factor, as the lymphatic system becomes less efficient with age, making it more difficult for the body to clear hemosiderin. (neuroseed.net)
  • Bronchoalveolar lavage was performed 12 to 18 hours after each race, and BAL fluid was analyzed for RBC and leukocyte counts and hemosiderin content. (avma.org)
  • Conventional quantification of hemosiderin uses semi-quantitative MRI scores, assigning grades of small, moderate, or large to assess the burden of hemosiderin. (ismrm.org)
  • However, recent studies have shown that hemosiderin may not always be able to prevent the release of free iron from its stores. (livingwithss.com)
  • iron in hemosiderin turns blue to black when exposed to potassium ferrocyanide. (wikipedia.org)