Helicobacter felis
Helicobacter
Helicobacter Infections
Helicobacter pylori
Rickettsia felis
Urease
Gastric Mucosa
Helicobacter heilmannii
Cat Diseases
Stomach
Felis
Parietal Cells, Gastric
Cats
Dog Diseases
Helicobacter hepaticus
Ctenocephalides
Dogs
RNA, Ribosomal, 16S
Molecular Sequence Data
Peptic Ulcer
Clarithromycin
Metronidazole
Amoxicillin
Mice, Inbred C57BL
Anti-Ulcer Agents
Omeprazole
Protective immunity against Helicobacter is characterized by a unique transcriptional signature. (1/53)
Immunization with a whole-cell sonicate vaccine of Helicobacter felis in conjunction with cholera toxin as a mucosal adjuvant induces long-term protective immunity in a majority of laboratory mice. We have combined gene expression profiling and immunohistochemical analysis on a set of immunized animals to better understand the mechanism of protection. The stomachs of protected animals exhibited a strikingly different transcriptional profile compared with those of nonprotected or control mice, indicating that vaccination targets the appropriate site and leaves a molecular signature. Among the genes whose up-regulation is significantly correlated with protection are a number of adipocyte-specific factors. These include the fat-cell-specific cytokines adipsin, resistin, and adiponectin and the adipocyte surface marker CD36. Interestingly, potentially protective T and B lymphocytes can be found embedded in the adipose tissue surrounding protected stomachs but never in control or unprotected stomachs. Adipsin-specific immunohistochemical staining of protected stomach sections further revealed molecular cross-talk between adjacent lymphoid and adipose cell populations. We propose a mechanism of protection that involves the effector responses of either or both lymphocyte subclasses as well as the previously unappreciated paracrine functions of adipose tissue surrounding the resident lymphocytes. (+info)Treatment of Helicobacter gastritis with IL-4 requires somatostatin. (2/53)
Fifty percent of the world's population is infected with Helicobacter pylori; however, treatment has been insufficient to eradicate the organisms due to rising antibiotic resistance. Helicobacter infection is characterized by induction of a T helper 1 lymphocyte (Th1) immune response, hypergastrinemia, and suppressed tissue somatostatin (SOM) levels. However, the mechanism by which the immune response regulates acid secretion is not known. We show here that treatment with IFN-gamma, a Th1 cytokine, was sufficient to induce gastritis, increase gastrin, and decrease SOM levels within 7 days. In contrast, the T helper 2 lymphocyte cytokine IL-4 increased SOM levels and effectively suppressed gastrin expression and secretion. This result demonstrated reciprocal regulation of acid regulatory peptides by immune modulators. IL-4 pretreatment prevented gastritis in infected wild-type but not in SOM null mice. Thus, the ability of IL-4 to oppose a Th1-mediated infection required SOM. Immunofluorescence was used to document the presence of IL-4 receptors on the gastric SOM-secreting cell (D cell). Moreover, IL-4 stimulated SOM release from primary D cell cultures. Treatment of mice chronically infected with Helicobacter felis for 2 mo with the SOM analogue octreotide resolved the inflammation. Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells. (+info)Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. (3/53)
The mechanisms by which the immune response can eradicate gastric Helicobacter infection are unknown. We hypothesized that Helicobacter-induced activation of the complement system could promote both inflammation and eradication of Helicobacter from the stomach. In vitro studies demonstrated that Helicobacter felis activates complement in normal mouse serum but not in serum from Rag2(-/-) mice, indicating that H. felis activates complement through the classical pathway. Next, we infected complement-depleted wild-type control and interleukin-10-deficient (IL-10(-/-)) mice with H. felis. Helicobacter infection of wild-type mice elicited a mild, focal gastritis and did not alter serum complement levels. Infection of IL-10(-/-) mice with H. felis elicited severe gastritis. After the initial colonization, the IL-10(-/-) mice completely cleared Helicobacter from the stomach by day 8. In contrast to wild-type mice, H. felis-infected IL-10(-/-) mice had a marked increase in serum complement levels. Complement depletion of wild-type mice did not affect the intensity of gastric inflammation or the extent of Helicobacter colonization compared to that for the wild-type control mice. In contrast, complement depletion of Helicobacter-infected IL-10(-/-) mice decreased the severity of gastritis, decreased the Helicobacter-induced infiltration of neutrophils into the stomach, and delayed the clearance of bacteria. In vitro studies of stimulated splenocytes and neutrophils from IL-10(-/-) mice produced a twofold increase in complement production compared to that for wild-type mice. Pretreatment with IL-10 inhibited this increase. These studies identify a role for complement in the local immune response to gastric Helicobacter in IL-10(-/-) mice and suggest a role for IL-10 in the regulation of complement production. (+info)Multiplex PCR assay for differentiation of Helicobacter felis, H. bizzozeronii, and H. salomonis. (4/53)
Helicobacter felis, Helicobacter bizzozeronii, and Helicobacter salomonis are frequently found in the gastric mucous membrane of dogs and cats. These large spiral organisms are phylogenetically highly related to each other. Their fastidious nature makes it difficult to cultivate them in vitro, hampering traditional identification methods. We describe here a multiplex PCR test based on the tRNA intergenic spacers and on the urease gene, combined with capillary electrophoresis, that allows discrimination of these three species. In combination with previously described 16S ribosomal DNA-based primers specific for the nonculturable "Candidatus Helicobacter suis," our procedure was shown to be very useful in determining the species identity of "Helicobacter heilmannii"-like organisms observed in human stomachs and will facilitate research concerning their possible zoonotic importance. (+info)Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. (5/53)
The host immune response plays a critical role in determining disease manifestations of chronic infections. Inadequate immune response may fail to control infection, although in other cases the specific immune response may be the cause of tissue damage and disease. The majority of patients with chronic infections are infected by more than one organism yet the interaction between multiple active infections is not known, nor is the impact on disease outcome clear. Using the BALB/c strain of mice, we show that Toxoplasma gondii infection in a host infected with Helicobacter felis alters the natural outcome of T. gondii infection, allowing uncontrolled tachyzoite replication and severe organ damage. Survival rates decrease from 95% in T. gondii infection alone to 50% in dual-infected mice. In addition, infection with T. gondii alters the specific H. felis immune response, converting a previously resistant host to a susceptible phenotype. Gastric mucosal IFN-gamma and IL-12 were significantly elevated and IL-10 substantially reduced in dual-infected mice. These changes were associated with severe gastric mucosal inflammation, parietal cell loss, atrophy, and metaplastic cell changes. These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease. (+info)Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. (6/53)
Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of microbial ligands including bacteria, fungi, and viruses. This study demonstrates that distinct TLRs are responsible for the recognition of Helicobacter lipopolysaccharide (LPS) versus intact Helicobacter bacteria. We show that the cytokine-inducing activity of Helicobacter LPS was mediated by TLR4; i.e., TLR4-deficient macrophages were unresponsive to Helicobacter pylori LPS. Surprisingly, the cytokine response to whole Helicobacter bacteria (H. pylori, H. hepaticus, and H. felis) was mediated not by TLR4 but rather by TLR2. Studies of HEK293 transfectants revealed that expression of human TLR2 was sufficient to confer responsiveness to intact Helicobacter bacteria, but TLR4 transfection was not sufficient. Our studies further suggest that cag pathogenicity island genes may modulate the TLR2 agonist activity of H. pylori as cagA+ bacteria were more active on a per-cell basis compared to cagA mutant bacteria for interleukin-8 (IL-8) cytokine secretion. Consistent with the transfection studies, analysis of knockout mice demonstrated that TLR2 was required for the cytokine response to intact Helicobacter bacteria. Macrophages from both wild-type and TLR4-deficient mice produced a robust cytokine secretion response (IL-6 and MCP-1) when stimulated with intact Helicobacter bacteria. In contrast, macrophages from TLR2-deficient mice were profoundly unresponsive to intact Helicobacter stimulation, failing to secrete cytokines even at high (100:1) bacterium-to-macrophage ratios. Our studies suggest that TLR2 may be the dominant innate immune receptor for recognition of gastrointestinal Helicobacter species. (+info)Gastric cancer originating from bone marrow-derived cells. (7/53)
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression. (+info)Gastric helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthase. (8/53)
Persistent Helicobacter felis infection in (C57BL/6 x 129SvEv)F1 mice induces chronic gastritis. Expression of inducible nitric oxide synthase (iNOS) is upregulated in response to Helicobacter infection. In this study, 20 10-week-old iNOS-/- mice and 20 wild-type [(C57BL/6 x 129SvEv)F1] mice were infected with H. felis by oral gavage and were assessed histologically and serologically at 32 weeks postinfection. Equal numbers of uninfected controls were sham inoculated. The mice were scored for severity of gastric inflammation, hyperplasia, glandular atrophy, and mucous metaplasia in the corpus and for the level of helicobacter colonization. The immunoglobulin G1 (IgG1), IgG2a, and IgG2c antibody responses to H. felis were determined. As a secondary measure, serum cholesterol levels were assessed. iNOS-/- mice have a propensity for increased serum cholesterol, and although controversial, several human epidemiologic studies have demonstrated an association between Helicobacter infection and several risk factors for cardiovascular disease, including elevated serum cholesterol. Nevertheless, no differences in serum cholesterol levels were observed between the H. felis-infected and -uninfected iNOS-/- mice in this study. The uninfected animals had minimal to no gastric pathology. The gastric pathology scores for the infected animals were reduced significantly in the iNOS-deficient mice relative to those for the wild-type mice (all P <0.01). Helicobacter-infected iNOS-/- mice had chronic lymphoid infiltration and negligible to mild glandular atrophy and mucous metaplasia in the fundic mucosa, while H. felis-infected wild-type mice had severe atrophic and metaplastic mucosal changes. The atrophic gastritis in the infected wild-type mice, particularly the female mice, was also accompanied by greater granulocytic infiltration, antral hyperplasia, and diminished antral colonization, unlike that in the infected iNOS-/- mice. iNOS-/- mice developed significantly lower Th1-associated IgG2c antibody responses to H. felis (P <0.0003); the Th2-associated IgG1 responses were similar (P=0.09), suggesting a greater effect of the iNOS defect on Th1 responses. H. felis colonization was significantly greater in the iNOS-deficient mice. These findings are indicative of an impaired Th1 component of the H. felis-induced inflammatory response when the influence of iNOS is removed. (+info)"Helicobacter felis" is a gram-negative, spiral-shaped bacterium that colonizes the stomachs of cats and other animals. It is closely related to "Helicobacter pylori," which is a well-known cause of gastritis, peptic ulcers, and gastric cancer in humans. "Helicobacter felis" has been associated with similar gastrointestinal diseases in cats and has been occasionally found in human stomachs, although its role in human pathogenesis is not as clearly established as that of "Helicobacter pylori."
"Helicobacter" is a genus of gram-negative, spiral-shaped bacteria that are commonly found in the stomach. The most well-known species is "Helicobacter pylori," which is known to cause various gastrointestinal diseases, such as gastritis, peptic ulcers, and gastric cancer. These bacteria are able to survive in the harsh acidic environment of the stomach by producing urease, an enzyme that neutralizes stomach acid. Infection with "Helicobacter pylori" is usually acquired in childhood and can persist for life if not treated.
Helicobacter infections are caused by the bacterium Helicobacter pylori (H. pylori), which colonizes the stomach lining and is associated with various gastrointestinal diseases. The infection can lead to chronic active gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer.
The spiral-shaped H. pylori bacteria are able to survive in the harsh acidic environment of the stomach by producing urease, an enzyme that neutralizes gastric acid in their immediate vicinity. This allows them to adhere to and colonize the epithelial lining of the stomach, where they can cause inflammation (gastritis) and disrupt the normal functioning of the stomach.
Transmission of H. pylori typically occurs through oral-oral or fecal-oral routes, and infection is more common in developing countries and in populations with lower socioeconomic status. The diagnosis of Helicobacter infections can be confirmed through various tests, including urea breath tests, stool antigen tests, or gastric biopsy with histology and culture. Treatment usually involves a combination of antibiotics and proton pump inhibitors to eradicate the bacteria and reduce stomach acidity.
Helicobacter pylori (H. pylori) is a gram-negative, microaerophilic bacterium that colonizes the stomach of approximately 50% of the global population. It is closely associated with gastritis and peptic ulcer disease, and is implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori infection is usually acquired in childhood and can persist for life if not treated. The bacterium's spiral shape and flagella allow it to penetrate the mucus layer and adhere to the gastric epithelium, where it releases virulence factors that cause inflammation and tissue damage. Diagnosis of H. pylori infection can be made through various tests, including urea breath test, stool antigen test, or histological examination of a gastric biopsy. Treatment typically involves a combination of antibiotics and proton pump inhibitors to eradicate the bacteria and promote healing of the stomach lining.
"Rickettsia felis" is a species of intracellular bacteria that can cause disease in humans and animals. It is the causative agent of flea-borne spotted fever, also known as cat scratch fever or flea-borne typhus. The bacterium is primarily transmitted to humans through the bite of infected fleas, such as the cat flea (Ctenocephalides felis).
"Rickettsia felis" can infect various types of cells in the body, including endothelial cells, which line the interior surface of blood vessels. The infection can cause symptoms such as fever, headache, muscle pain, and rash. In severe cases, it can lead to complications such as pneumonia, meningitis, or damage to internal organs.
It is important to note that "Rickettsia felis" infections are rare and are typically found in certain geographic regions, particularly in tropical and subtropical areas. Proper prevention measures, such as using insect repellent and wearing protective clothing, can help reduce the risk of infection. If you suspect that you may have been infected with "Rickettsia felis," it is important to seek medical attention promptly.
Urease is an enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It is found in various organisms, including bacteria, fungi, and plants. In medicine, urease is often associated with certain bacterial infections, such as those caused by Helicobacter pylori, which can produce large amounts of this enzyme. The presence of urease in these infections can lead to increased ammonia production, contributing to the development of gastritis and peptic ulcers.
Gastric mucosa refers to the innermost lining of the stomach, which is in contact with the gastric lumen. It is a specialized mucous membrane that consists of epithelial cells, lamina propria, and a thin layer of smooth muscle. The surface epithelium is primarily made up of mucus-secreting cells (goblet cells) and parietal cells, which secrete hydrochloric acid and intrinsic factor, and chief cells, which produce pepsinogen.
The gastric mucosa has several important functions, including protection against self-digestion by the stomach's own digestive enzymes and hydrochloric acid. The mucus layer secreted by the epithelial cells forms a physical barrier that prevents the acidic contents of the stomach from damaging the underlying tissues. Additionally, the bicarbonate ions secreted by the surface epithelial cells help neutralize the acidity in the immediate vicinity of the mucosa.
The gastric mucosa is also responsible for the initial digestion of food through the action of hydrochloric acid and pepsin, an enzyme that breaks down proteins into smaller peptides. The intrinsic factor secreted by parietal cells plays a crucial role in the absorption of vitamin B12 in the small intestine.
The gastric mucosa is constantly exposed to potential damage from various factors, including acid, pepsin, and other digestive enzymes, as well as mechanical stress due to muscle contractions during digestion. To maintain its integrity, the gastric mucosa has a remarkable capacity for self-repair and regeneration. However, chronic exposure to noxious stimuli or certain medical conditions can lead to inflammation, erosions, ulcers, or even cancer of the gastric mucosa.
Gastritis is a medical condition characterized by inflammation of the lining of the stomach. It can be caused by various factors, including bacterial infections (such as Helicobacter pylori), regular use of nonsteroidal anti-inflammatory drugs (NSAIDs), excessive alcohol consumption, and stress.
Gastritis can present with a range of symptoms, such as abdominal pain or discomfort, nausea, vomiting, loss of appetite, and bloating. In some cases, gastritis may not cause any noticeable symptoms. Depending on the severity and duration of inflammation, gastritis can lead to complications like stomach ulcers or even stomach cancer if left untreated.
There are two main types of gastritis: acute and chronic. Acute gastritis develops suddenly and may last for a short period, while chronic gastritis persists over time, often leading to atrophy of the stomach lining. Diagnosis typically involves endoscopy and tissue biopsy to assess the extent of inflammation and rule out other potential causes of symptoms. Treatment options depend on the underlying cause but may include antibiotics, proton pump inhibitors, or lifestyle modifications.
Helicobacter heilmannii (previously known as Gastrospirillum hominis) is a gram-negative, spiral-shaped bacterium that can be found in the stomach and is associated with gastritis and peptic ulcer disease. It is one of several species of Helicobacter that can infect the stomach, along with H. pylori, which is a more common cause of these conditions. The infection by H. heilmannii is less common and its transmission routes are not well understood, but it is believed to be associated with close contact with animals, particularly dogs and cats. Its identification and diagnosis can be challenging due to difficulties in culturing the bacterium and detecting it in gastric biopsies.
There are many diseases that can affect cats, and the specific medical definitions for these conditions can be quite detailed and complex. However, here are some common categories of feline diseases and examples of each:
1. Infectious diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include:
* Feline panleukopenia virus (FPV), also known as feline parvovirus, which can cause severe gastrointestinal symptoms and death in kittens.
* Feline calicivirus (FCV), which can cause upper respiratory symptoms such as sneezing and nasal discharge.
* Feline leukemia virus (FeLV), which can suppress the immune system and lead to a variety of secondary infections and diseases.
* Bacterial infections, such as those caused by Pasteurella multocida or Bartonella henselae, which can cause abscesses or other symptoms.
2. Neoplastic diseases: These are cancerous conditions that can affect various organs and tissues in cats. Examples include:
* Lymphoma, which is a common type of cancer in cats that can affect the lymph nodes, spleen, liver, and other organs.
* Fibrosarcoma, which is a type of soft tissue cancer that can arise from fibrous connective tissue.
* Squamous cell carcinoma, which is a type of skin cancer that can be caused by exposure to sunlight or tobacco smoke.
3. Degenerative diseases: These are conditions that result from the normal wear and tear of aging or other factors. Examples include:
* Osteoarthritis, which is a degenerative joint disease that can cause pain and stiffness in older cats.
* Dental disease, which is a common condition in cats that can lead to tooth loss, gum inflammation, and other problems.
* Heart disease, such as hypertrophic cardiomyopathy (HCM), which is a thickening of the heart muscle that can lead to congestive heart failure.
4. Hereditary diseases: These are conditions that are inherited from a cat's parents and are present at birth or develop early in life. Examples include:
* Polycystic kidney disease (PKD), which is a genetic disorder that causes cysts to form in the kidneys and can lead to kidney failure.
* Hypertrophic cardiomyopathy (HCM), which can be inherited as an autosomal dominant trait in some cats.
* Progressive retinal atrophy (PRA), which is a group of genetic disorders that cause degeneration of the retina and can lead to blindness.
In anatomical terms, the stomach is a muscular, J-shaped organ located in the upper left portion of the abdomen. It is part of the gastrointestinal tract and plays a crucial role in digestion. The stomach's primary functions include storing food, mixing it with digestive enzymes and hydrochloric acid to break down proteins, and slowly emptying the partially digested food into the small intestine for further absorption of nutrients.
The stomach is divided into several regions, including the cardia (the area nearest the esophagus), the fundus (the upper portion on the left side), the body (the main central part), and the pylorus (the narrowed region leading to the small intestine). The inner lining of the stomach, called the mucosa, is protected by a layer of mucus that prevents the digestive juices from damaging the stomach tissue itself.
In medical contexts, various conditions can affect the stomach, such as gastritis (inflammation of the stomach lining), peptic ulcers (sores in the stomach or duodenum), gastroesophageal reflux disease (GERD), and stomach cancer. Symptoms related to the stomach may include abdominal pain, bloating, nausea, vomiting, heartburn, and difficulty swallowing.
"Felis" is a genus that includes small cats, such as the domestic cat (Felis catus) and several wild species. Members of this genus are typically solitary animals with lithe bodies and flexible limbs, well-suited for hunting birds and small mammals. They have sharp retractile claws, and most species have a keen sense of smell and excellent night vision. The genus Felis is part of the family Felidae, which also includes larger cats such as lions, tigers, and leopards.
Parietal cells, also known as oxyntic cells, are a type of cell found in the gastric glands of the stomach lining. They play a crucial role in digestion by releasing hydrochloric acid and intrinsic factor into the stomach lumen. Hydrochloric acid is essential for breaking down food particles and creating an acidic environment that kills most bacteria, while intrinsic factor is necessary for the absorption of vitamin B12 in the small intestine. Parietal cells are stimulated by histamine, acetylcholine, and gastrin to release their secretory products.
"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.
Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.
Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.
In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.
There is no medical definition for "dog diseases" as it is too broad a term. However, dogs can suffer from various health conditions and illnesses that are specific to their species or similar to those found in humans. Some common categories of dog diseases include:
1. Infectious Diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include distemper, parvovirus, kennel cough, Lyme disease, and heartworms.
2. Hereditary/Genetic Disorders: Some dogs may inherit certain genetic disorders from their parents. Examples include hip dysplasia, elbow dysplasia, progressive retinal atrophy (PRA), and degenerative myelopathy.
3. Age-Related Diseases: As dogs age, they become more susceptible to various health issues. Common age-related diseases in dogs include arthritis, dental disease, cancer, and cognitive dysfunction syndrome (CDS).
4. Nutritional Disorders: Malnutrition or improper feeding can lead to various health problems in dogs. Examples include obesity, malnutrition, and vitamin deficiencies.
5. Environmental Diseases: These are caused by exposure to environmental factors such as toxins, allergens, or extreme temperatures. Examples include heatstroke, frostbite, and toxicities from ingesting harmful substances.
6. Neurological Disorders: Dogs can suffer from various neurological conditions that affect their nervous system. Examples include epilepsy, intervertebral disc disease (IVDD), and vestibular disease.
7. Behavioral Disorders: Some dogs may develop behavioral issues due to various factors such as anxiety, fear, or aggression. Examples include separation anxiety, noise phobias, and resource guarding.
It's important to note that regular veterinary care, proper nutrition, exercise, and preventative measures can help reduce the risk of many dog diseases.
Siphonaptera is the scientific order that includes fleas. Fleas are small, wingless insects with laterally compressed bodies and strong legs adapted for jumping. They are external parasites, living by hematophagy off the blood of mammals and birds. Fleas can be a nuisance to their hosts, and some people and animals have allergic reactions to flea saliva. Fleas can also transmit diseases, such as bubonic plague and murine typhus, and parasites like tapeworms.
Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.
Stomach neoplasms refer to abnormal growths in the stomach that can be benign or malignant. They include a wide range of conditions such as:
1. Gastric adenomas: These are benign tumors that develop from glandular cells in the stomach lining.
2. Gastrointestinal stromal tumors (GISTs): These are rare tumors that can be found in the stomach and other parts of the digestive tract. They originate from the stem cells in the wall of the digestive tract.
3. Leiomyomas: These are benign tumors that develop from smooth muscle cells in the stomach wall.
4. Lipomas: These are benign tumors that develop from fat cells in the stomach wall.
5. Neuroendocrine tumors (NETs): These are tumors that develop from the neuroendocrine cells in the stomach lining. They can be benign or malignant.
6. Gastric carcinomas: These are malignant tumors that develop from the glandular cells in the stomach lining. They are the most common type of stomach neoplasm and include adenocarcinomas, signet ring cell carcinomas, and others.
7. Lymphomas: These are malignant tumors that develop from the immune cells in the stomach wall.
Stomach neoplasms can cause various symptoms such as abdominal pain, nausea, vomiting, weight loss, and difficulty swallowing. The diagnosis of stomach neoplasms usually involves a combination of imaging tests, endoscopy, and biopsy. Treatment options depend on the type and stage of the neoplasm and may include surgery, chemotherapy, radiation therapy, or targeted therapy.
"Helicobacter hepaticus" is a gram-negative, spiral-shaped bacterium that colonizes the liver of various animals, including primates. It was initially identified in 1992 and has been associated with chronic active hepatitis and hepatic adenocarcinoma (liver cancer) in mice. While its role in human disease is not fully understood, some studies have suggested a possible link between H. hepaticus infection and liver inflammation or cancer in humans. However, more research is needed to confirm this association and establish the clinical significance of H. hepaticus in human health.
Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.
Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.
Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.
Ctenocephalides is a genus of parasitic insects in the family Pulicidae, commonly known as fleas. There are two main species within this genus that are of medical importance: Ctenocephalides canis (the dog flea) and Ctenocephalides felis (the cat flea). These flea species are vectors for various disease-causing pathogens and parasites, which can affect both animals and humans. They can cause irritation, allergic reactions, and transmit bacterial infections such as murine typhus and endemic typhus. Proper identification and control of Ctenocephalides infestations are essential for preventing the spread of these diseases.
I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.
If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.
Ribosomal RNA (rRNA) is a type of RNA that combines with proteins to form ribosomes, which are complex structures inside cells where protein synthesis occurs. The "16S" refers to the sedimentation coefficient of the rRNA molecule, which is a measure of its size and shape. In particular, 16S rRNA is a component of the smaller subunit of the prokaryotic ribosome (found in bacteria and archaea), and is often used as a molecular marker for identifying and classifying these organisms due to its relative stability and conservation among species. The sequence of 16S rRNA can be compared across different species to determine their evolutionary relationships and taxonomic positions.
Rickettsia infections are a group of diseases caused by bacteria belonging to the genus Rickettsia. These bacteria are obligate intracellular pathogens, meaning they can only survive and reproduce inside host cells. They are primarily transmitted to humans through the bites of infected arthropods such as ticks, fleas, and lice.
The different types of Rickettsia infections include:
1. Rocky Mountain Spotted Fever (RMSF): This is the most severe and common rickettsial infection in the United States. It is caused by Rickettsia rickettsii and transmitted through the bite of an infected tick.
2. Mediterranean Spotted Fever (MSF): Also known as boutonneuse fever, this infection is prevalent in Mediterranean countries and is caused by Rickettsia conorii. It is transmitted through the bite of an infected dog tick or a brown dog tick.
3. Typhus Group: This group includes epidemic typhus, caused by Rickettsia prowazekii, and murine typhus, caused by Rickettsia typhi. Both are transmitted to humans through the feces of infected lice or fleas.
4. Scrub Typhus: Caused by Orientia tsutsugamushi, this infection is prevalent in Southeast Asia and is transmitted through the bite of an infected mite (chigger).
5. Rickettsialpox: This is a mild rickettsial infection caused by Rickettsia akari and is transmitted to humans through the bites of infected mites.
Symptoms of Rickettsia infections may include fever, headache, muscle pain, nausea, vomiting, and a rash. If left untreated, these infections can lead to severe complications such as damage to blood vessels, inflammation of the brain (encephalitis), or even death. Treatment typically involves antibiotics such as doxycycline or chloramphenicol. Preventive measures include using insect repellent, wearing protective clothing, and promptly removing ticks after being outdoors.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
A peptic ulcer is a sore or erosion in the lining of your stomach and the first part of your small intestine (duodenum). The most common causes of peptic ulcers are bacterial infection and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen.
The symptoms of a peptic ulcer include abdominal pain, often in the upper middle part of your abdomen, which can be dull, sharp, or burning and may come and go for several days or weeks. Other symptoms can include bloating, burping, heartburn, nausea, vomiting, loss of appetite, and weight loss. Severe ulcers can cause bleeding in the digestive tract, which can lead to anemia, black stools, or vomit that looks like coffee grounds.
If left untreated, peptic ulcers can result in serious complications such as perforation (a hole through the wall of the stomach or duodenum), obstruction (blockage of the digestive tract), and bleeding. Treatment for peptic ulcers typically involves medications to reduce acid production, neutralize stomach acid, and kill the bacteria causing the infection. In severe cases, surgery may be required.
A flea infestation refers to an unwanted invasion and multiplication of fleas (small, wingless insects that jump) in living spaces or on a host organism, usually a mammal or bird. These parasites feed on the blood of their hosts, causing itching, discomfort, and sometimes transmitting diseases.
Flea infestations are particularly common in domestic animals such as dogs and cats, but they can also affect humans. The most prevalent flea species is the cat flea (Ctenocephalides felis), although dog fleas (Ctenocephalides canis) and human fleas (Pulex irritans) can also cause infestations.
Signs of a flea infestation include:
1. Seeing live fleas on the host or in their living environment.
2. Finding flea dirt, which looks like small black specks and is actually flea feces, on the host or their bedding.
3. Excessive scratching, biting, or licking by the host, leading to skin irritation, redness, and hair loss.
4. Presence of flea eggs, which are tiny and white, in the host's fur or living spaces.
5. Development of secondary skin infections due to constant scratching and biting.
Preventing and controlling flea infestations involves regular vacuuming, washing pet bedding, using topical or oral preventatives for pets, and sometimes employing professional pest control services.
Clarithromycin is a antibiotic medication used to treat various types of bacterial infections, including respiratory, skin, and soft tissue infections. It is a member of the macrolide antibiotic family, which works by inhibiting bacterial protein synthesis. Clarithromycin is available by prescription and is often used in combination with other medications to treat conditions such as Helicobacter pylori infection and Mycobacterium avium complex (MAC) infection.
The medical definition of clarithromycin is:
"A antibiotic medication used to treat various types of bacterial infections, belonging to the macrolide antibiotic family. It works by inhibiting bacterial protein synthesis and is available by prescription."
Metronidazole is an antibiotic and antiprotozoal medication. It is primarily used to treat infections caused by anaerobic bacteria and certain parasites. Metronidazole works by interfering with the DNA of these organisms, which inhibits their ability to grow and multiply.
It is available in various forms, including tablets, capsules, creams, and gels, and is often used to treat conditions such as bacterial vaginosis, pelvic inflammatory disease, amebiasis, giardiasis, and pseudomembranous colitis.
Like all antibiotics, metronidazole should be taken only under the direction of a healthcare provider, as misuse can lead to antibiotic resistance and other complications.
Amoxicillin is a type of antibiotic known as a penicillin. It works by interfering with the ability of bacteria to form cell walls, which is necessary for their growth and survival. By disrupting this process, amoxicillin can kill bacteria and help to clear up infections.
Amoxicillin is used to treat a variety of bacterial infections, including respiratory tract infections, ear infections, skin infections, and urinary tract infections. It is available as a tablet, capsule, chewable tablet, or liquid suspension, and is typically taken two to three times a day.
Like all antibiotics, amoxicillin should be used only under the direction of a healthcare provider, and it is important to take the full course of treatment as prescribed, even if symptoms improve before the medication is finished. Misuse of antibiotics can lead to the development of drug-resistant bacteria, which can make infections more difficult to treat in the future.
Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.
Bacterial proteins can be classified into different categories based on their function, such as:
1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.
Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.
C57BL/6 (C57 Black 6) is an inbred strain of laboratory mouse that is widely used in biomedical research. The term "inbred" refers to a strain of animals where matings have been carried out between siblings or other closely related individuals for many generations, resulting in a population that is highly homozygous at most genetic loci.
The C57BL/6 strain was established in 1920 by crossing a female mouse from the dilute brown (DBA) strain with a male mouse from the black strain. The resulting offspring were then interbred for many generations to create the inbred C57BL/6 strain.
C57BL/6 mice are known for their robust health, longevity, and ease of handling, making them a popular choice for researchers. They have been used in a wide range of biomedical research areas, including studies of cancer, immunology, neuroscience, cardiovascular disease, and metabolism.
One of the most notable features of the C57BL/6 strain is its sensitivity to certain genetic modifications, such as the introduction of mutations that lead to obesity or impaired glucose tolerance. This has made it a valuable tool for studying the genetic basis of complex diseases and traits.
Overall, the C57BL/6 inbred mouse strain is an important model organism in biomedical research, providing a valuable resource for understanding the genetic and molecular mechanisms underlying human health and disease.
Dyspepsia is a medical term that refers to discomfort or pain in the upper abdomen, often accompanied by symptoms such as bloating, nausea, belching, and early satiety (feeling full quickly after starting to eat). It is also commonly known as indigestion. Dyspepsia can have many possible causes, including gastroesophageal reflux disease (GERD), peptic ulcers, gastritis, and functional dyspepsia (a condition in which there is no obvious structural or biochemical explanation for the symptoms). Treatment for dyspepsia depends on the underlying cause.
Stomach diseases refer to a range of conditions that affect the stomach, a muscular sac located in the upper part of the abdomen and is responsible for storing and digesting food. These diseases can cause various symptoms such as abdominal pain, nausea, vomiting, heartburn, indigestion, loss of appetite, and bloating. Some common stomach diseases include:
1. Gastritis: Inflammation of the stomach lining that can cause pain, irritation, and ulcers.
2. Gastroesophageal reflux disease (GERD): A condition where stomach acid flows back into the esophagus, causing heartburn and damage to the esophageal lining.
3. Peptic ulcers: Open sores that develop on the lining of the stomach or duodenum, often caused by bacterial infections or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).
4. Stomach cancer: Abnormal growth of cancerous cells in the stomach, which can spread to other parts of the body if left untreated.
5. Gastroparesis: A condition where the stomach muscles are weakened or paralyzed, leading to difficulty digesting food and emptying the stomach.
6. Functional dyspepsia: A chronic disorder characterized by symptoms such as pain, bloating, and fullness in the upper abdomen, without any identifiable cause.
7. Eosinophilic esophagitis: A condition where eosinophils, a type of white blood cell, accumulate in the esophagus, causing inflammation and difficulty swallowing.
8. Stomal stenosis: Narrowing of the opening between the stomach and small intestine, often caused by scar tissue or surgical complications.
9. Hiatal hernia: A condition where a portion of the stomach protrudes through the diaphragm into the chest cavity, causing symptoms such as heartburn and difficulty swallowing.
These are just a few examples of stomach diseases, and there are many other conditions that can affect the stomach. Proper diagnosis and treatment are essential for managing these conditions and preventing complications.
Anti-ulcer agents are a class of medications that are used to treat and prevent ulcers in the gastrointestinal tract. These medications work by reducing the production of stomach acid, neutralizing stomach acid, or protecting the lining of the stomach and duodenum from damage caused by stomach acid.
There are several types of anti-ulcer agents, including:
1. Proton pump inhibitors (PPIs): These medications block the action of proton pumps in the stomach, which are responsible for producing stomach acid. PPIs include drugs such as omeprazole, lansoprazole, and pantoprazole.
2. H-2 receptor antagonists: These medications block the action of histamine on the H-2 receptors in the stomach, reducing the production of stomach acid. Examples include ranitidine, famotidine, and cimetidine.
3. Antacids: These medications neutralize stomach acid and provide quick relief from symptoms such as heartburn and indigestion. Common antacids include calcium carbonate, magnesium hydroxide, and aluminum hydroxide.
4. Protective agents: These medications form a barrier between the stomach lining and stomach acid, protecting the lining from damage. Examples include sucralfate and misoprostol.
Anti-ulcer agents are used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. It is important to take these medications as directed by a healthcare provider, as they can have side effects and interactions with other medications.
Bacterial antigens are substances found on the surface or produced by bacteria that can stimulate an immune response in a host organism. These antigens can be proteins, polysaccharides, teichoic acids, lipopolysaccharides, or other molecules that are recognized as foreign by the host's immune system.
When a bacterial antigen is encountered by the host's immune system, it triggers a series of responses aimed at eliminating the bacteria and preventing infection. The host's immune system recognizes the antigen as foreign through the use of specialized receptors called pattern recognition receptors (PRRs), which are found on various immune cells such as macrophages, dendritic cells, and neutrophils.
Once a bacterial antigen is recognized by the host's immune system, it can stimulate both the innate and adaptive immune responses. The innate immune response involves the activation of inflammatory pathways, the recruitment of immune cells to the site of infection, and the production of antimicrobial peptides.
The adaptive immune response, on the other hand, involves the activation of T cells and B cells, which are specific to the bacterial antigen. These cells can recognize and remember the antigen, allowing for a more rapid and effective response upon subsequent exposures.
Bacterial antigens are important in the development of vaccines, as they can be used to stimulate an immune response without causing disease. By identifying specific bacterial antigens that are associated with virulence or pathogenicity, researchers can develop vaccines that target these antigens and provide protection against infection.
Omeprazole is defined as a proton pump inhibitor (PPI) used in the treatment of gastroesophageal reflux disease (GERD), gastric ulcers, and other conditions where reducing stomach acid is desired. It works by blocking the action of the proton pumps in the stomach, which are responsible for producing stomach acid. By inhibiting these pumps, omeprazole reduces the amount of acid produced in the stomach, providing relief from symptoms such as heartburn and pain caused by excess stomach acid.
It is available in various forms, including tablets, capsules, and oral suspension, and is typically taken once or twice a day, depending on the condition being treated. As with any medication, omeprazole should be used under the guidance of a healthcare professional, and its potential side effects and interactions with other medications should be carefully considered before use.
"Chlamydophila" is a genus of bacteria that includes several species that can cause human diseases. The most well-known species in this genus is "Chlamydophila trachomatis," which is the leading cause of preventable blindness worldwide and can also cause sexually transmitted infections (STIs). Other species in the genus include "Chlamydophila pneumoniae," which can cause respiratory infections, and "Chlamydophila psittaci," which can cause psittacosis, a type of pneumonia that is often associated with exposure to birds.
It's worth noting that the taxonomy of these bacteria has been subject to some debate and revision in recent years. Some experts have proposed reclassifying the genus "Chlamydophila" as a subgroup within the genus "Chlamydia," which would make the species "Chlamydophila trachomatis" become "Chlamydia trachomatis," and so on. However, this proposal has not been universally accepted, and both classifications continue to be used in the scientific literature.
Pylori14
- Helicobacter pylori (H. pylori) is by far the best known Helicobacter species, primarily because humans infected with it may develop gastrointestinal tract diseases such as stomach inflammation, stomach ulcers, duodenal ulcers, stomach cancers of the nonlymphoma type, and various subtypes of extranodal marginal zone lymphomass, e.g. those of the stomach, small intestines, large intestines, and rectumn. (wikipedia.org)
- Other non-H. pylori species that are known to be associated with these gastrointestinal diseases are Helicobacter bizzozeronii, Helicobacter salomonis, Helicobacter suis, and Helicobacter heilmannii s.s. (wikipedia.org)
- Ammonia production is of great importance for the gastric pathogen Helicobacter pylori as a nitrogen source, as a compound protecting against gastric acidity, and as a cytotoxic molecule. (pasteur.fr)
- Phylogenetic trees based upon the sequences of H. pylori amiE and amiF genes and their respective homologs from other organisms as well as the amidase gene distribution among Helicobacter species are strongly suggestive of amidase acquisition by horizontal gene transfer. (pasteur.fr)
- Mongolian gerbils infected with Helicobacter pylori (Hp) develop goblet cell intestinal metaplasia and adenocarcinoma, but the presence of SPEM has not been studied in gerbils. (fujita-hu.ac.jp)
- Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bacterial overgrowth are all considered important factors for induction of gastric cancer. (breakawaymatcha.com)
- In this study, we assessed the bactericidal and/or bacteriostatic effect of green tea against Helicobacter felis and H. pylori in vitro and evaluated the effects of green tea on the development of Helicobacter-induced gastritis in an animal model. (breakawaymatcha.com)
- Helicobacter pylori" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. (rush.edu)
- This graph shows the total number of publications written about "Helicobacter pylori" by people in this website by year, and whether "Helicobacter pylori" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "Helicobacter pylori" by people in Profiles. (rush.edu)
- Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil. (rush.edu)
- Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, K?nig W, Engel J, Backert S. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. (rush.edu)
- Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis. (rush.edu)
Spasmolytic polypeptide-expressing1
- Here we demonstrated that an inflammasome molecule, absent in melanoma 2 (Aim2), was upregulated in patients with gastric cancer and in spasmolytic polypeptide-expressing metaplasia of chronically Helicobacter felis-infected stomachs in mice. (jci.org)
Gastric Mucosa2
Mustelae1
- Among the gastric species, H. acinonychis possessed both amiE and amiF, H. felis carried only amiF, and H. mustelae was devoid of amidases. (pasteur.fr)
Gastritis1
- Components within natural remedies such as green tea could be further used for prevention and treatment of Helicobacter-induced gastritis in humans. (breakawaymatcha.com)
Heilmannii sensu lato2
- Because of their disease associations, these four Helicobacter species plus H. felis are often group together and termed Helicobacter heilmannii sensu lato. (wikipedia.org)
- It is important to diagnose H. felis and other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin, clarithromycin, plus a proton pump inhibitor or metronidazole, clarithromycin, plus a proton pump inhibitor) directed against the instigating bacterium. (wikipedia.org)
Metaplasia1
- Spasmolytic polypeptide (TFF2)-expressing metaplasia (SPEM) is observed in mucosa adjacent to human gastric cancer and in fundic glands showing oxyntic atrophy in Helicobacter felis-infected mice. (fujita-hu.ac.jp)
Infection9
- Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. (breakawaymatcha.com)
- Our data clearly demonstrate profound growth effects of green tea against Helicobacter and, importantly, demonstrate that green tea consumption can prevent gastric mucosal inflammation if ingested prior to exposure to Helicobacter infection. (breakawaymatcha.com)
- Rodent models of Helicobacter infection need to be refined to investigate any causal links to ID. (bmj.com)
- The aim of this study is to examine haematological parameters during the acute phase of Helicobacter infection in mice fed on iron-replete and iron deficient diets. (bmj.com)
- H felis infection was confirmed by urease test and histology. (bmj.com)
- This decrease was abrogated by H felis infection in dietary replete groups due to a slight increase (NS) in haemoglobin. (bmj.com)
- H felis infection made no difference to the levels observed. (bmj.com)
- This suggests that H felis has no impact on haematological parameters of iron status in the acute stage of the infection. (bmj.com)
- Other markers of iron status such as serum iron, TIBC and serum ferritin are needed to explore further the impact of Helicobacter infection. (bmj.com)
Mice3
- Methods Five-week-old female SPF C57Bl/6 mice were fed on iron deficient (2-6 ppm) or iron-replete (48 ppm) diets 3 weeks before oral gavage with H felis . (bmj.com)
- 0.001) in H felis infected and control mice on iron deficient diet compared to matched groups fed on iron-replete diet. (bmj.com)
- 0.001) in mice fed on iron defiecient diet, regardless of H felis status. (bmj.com)
Salomonis1
- NHPH represents a group of closely related but distinct bacterial species, mainly found in different animal species, such as H. felis , H. salomonis , H. bizzozeronii , H. heilmannii sensu stricto (s.s. (biomedcentral.com)
Bacteria1
- H. felis bacteria are detected in the stomachs of their natural hosts - cats, dogs, rabbits, and cheetahs. (wikipedia.org)
Condimentum1
- Nullam ac urna eu felis dapibus condimentum sit amet a augue. (nobelmedicalgroup.com)
Species3
- Helicobacter felis is a bacterial species in the Helicobacteraceae family, Campylobacterales order, Helicobacter genus. (wikipedia.org)
- We tested for the presence of the amiE and amiF genes and for amidase and formamidase activities in eleven Helicobacter species. (pasteur.fr)
- Since amidases are found only in Helicobacter species able to colonize the stomach, their acquisition might be related to selective pressure in this particular gastric environment. (pasteur.fr)
Bartonella1
- Anaplasma phagocytophilum (ticks), Rickettsia felis (fleas), Bartonella spp. (vin.com)
Bacterial1
- Components found in green tea have been shown to inhibit bacterial growth, including the growth of Helicobacter spp. (breakawaymatcha.com)
Stomachs2
- B ) RT-qPCR of IFN-β gene mRNA expression in 6-month H . felis -infected Aim2 -/- versus WT stomachs, relative to uninfected controls. (jci.org)
- D ) RT-qPCR analyses of gastric CD3 mRNA expression in 6-month H . felis -infected WT, Aim2 -/- , IFNAR1 -/- , and Aim2 -/- IFNAR1 -/- stomachs relative to uninfected controls. (jci.org)
Zoonotic2
- Reports suggest that individuals, including children, are infected with this bacterium by having close contact with one of these infected animals: H. heilmanni s.l.-associated diseases, including those associated with H. felis, appear to be zoonotic diseases, i.e. infectious diseases that are caused by pathogen that spread from animals to humans. (wikipedia.org)
- Helicobacter (H.) heilmannii sensu stricto (s.s.) is a zoonotic bacterium that naturally colonizes the stomach of dogs and cats. (biomedcentral.com)
Gene1
- A ) RT-qPCR of Ifnb1 (IFN-β gene) mRNA expression in Aim2 -/- versus WT bone marrow-derived macrophages (BMDCs) transfected with metaplastic gastric DNA from 6-month H . felis -infected stomach, relative to untransfected controls. (jci.org)
Humans1
- Humans infected with H. felis may also develop some of the same gastrointestinal diseases viz. (wikipedia.org)
Difference1
- All other parameters measured showed no difference due to H felis status in either diet cohort. (bmj.com)
Similar1
- Results Red blood cell count (RBC) and mean corpuscular haemoglobin concentration were similar in groups on both diets regardless of H felis status at 4 and 8 weeks. (bmj.com)
Heilmannii6
- Other non-H. pylori species that are known to be associated with these gastrointestinal diseases are Helicobacter bizzozeronii, Helicobacter salomonis, Helicobacter suis, and Helicobacter heilmannii s.s. (wikipedia.org)
- Because of their disease associations, these four Helicobacter species plus H. felis are often group together and termed Helicobacter heilmannii sensu lato. (wikipedia.org)
- It is important to diagnose H. felis and other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin, clarithromycin, plus a proton pump inhibitor or metronidazole, clarithromycin, plus a proton pump inhibitor) directed against the instigating bacterium. (wikipedia.org)
- 7. Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection. (nih.gov)
- All the H. heilmannii and H. felis PCR positive patients were also positive for H. pylori PCR amplification. (biomedcentral.com)
- The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name 'Candidatus Helicobacter heilmannii' is proposed. (uibk.ac.at)
Suis1
- Fifteen gastrospirilla detected in humans, primates and pigs clustered with 'Candidatus Helicobacter suis', thus expanding the host range for this organism. (uibk.ac.at)
Pylori infection4
- [ 291 ] Paradoxically, in vivo neutralization of IFN-γ was shown to alleviate H. felis -associated gastritis in mice, without affecting vaccine-induced protection, [ 292 ] and studies employing IFN-γ-knockout mice demonstrated that immunized animals were capable of inducing a protective immune response to H. pylori infection. (medscape.com)
- 2007. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. (nih.gov)
- Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. (oncotarget.com)
- Meanwhile, the definitions of 'etiological factor' and 'causality' do not support ' H. pylori infection is an etiological factor of peptic ulcers', and existing literatures have presented a controversial view on the role of Helicobacter pylori in peptic ulcers. (preprints.org)
Bizzozeronii1
- By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis, Helicobacter bizzozeronii and Helicobacter salomonis. (uibk.ac.at)
Lymphoid tissue2
Bacterium1
- Reports suggest that individuals, including children, are infected with this bacterium by having close contact with one of these infected animals: H. heilmanni s.l.-associated diseases, including those associated with H. felis, appear to be zoonotic diseases, i.e. infectious diseases that are caused by pathogen that spread from animals to humans. (wikipedia.org)
Primarily1
- Currently, peptic ulcers are widely studied as an infectious disease caused by Helicobacter pylori primarily due to 3 supporting evidences, and this etiology may explain the other 3 observations, but cannot confront the challenges of the 15 major characteristics and the other 75 observations/phenomena of peptic ulcers. (preprints.org)
Analyses1
- In-depth analyses find that all the 3 evidences supporting "peptic ulcers are an infectious disease caused by Helicobacter pylori " are deceiving, and 2 of the 3 explainable observations may have been misinterpreted. (preprints.org)
Infectious1
- Interestingly, if "peptic ulcers are an infectious disease caused by Helicobacter pylori " is considered an illusion, all the characteristics of the disease, along with all the clinical, epidemiological, and laboratory observations/phenomena, can be fully understood. (preprints.org)
Disease1
- Peptic ulcers are identified as a psychosomatic disease triggered by psychological stress, where Helicobacter pylori plays a secondary role in only the late phase of ulceration. (preprints.org)