Helicobacter felis: A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Helicobacter: A genus of gram-negative, spiral-shaped bacteria that has been isolated from the intestinal tract of mammals, including humans. It has been associated with PEPTIC ULCER.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 126.96.36.199.Helicobacter heilmannii: A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Stomach Neoplasms: Tumors or cancer of the STOMACH.Mice, Inbred C57BLMice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Helicobacter hepaticus: A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Dyspepsia: Impaired digestion, especially after eating.Bacterial Proteins: Proteins found in any species of bacterium.Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Stomach Diseases: Pathological processes involving the STOMACH.Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.Bismuth: A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.Pyloric Antrum: The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Breath Tests: Any tests done on exhaled air.2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Gastroscopy: Endoscopic examination, therapy or surgery of the interior of the stomach.Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Proton Pump Inhibitors: Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Tinidazole: A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.Lewis Blood-Group System: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.Pepsinogen A: This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.
Search of: Recruiting, Not yet recruiting, Available Studies | 'Helicobacter Infections' - List Results - ClinicalTrials.govIMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... ...
Association between Helicobacter pylori infection and duodenal ulcerSee 'Pathophysiology of and immune response to Helicobacter pylori infection'.). EVIDENCE LINKING HELICOBACTER PYLORI TO ... Association between Helicobacter pylori infection and duodenal ulcer. Author. Sheila E Crowe, MD, FRCPC, FACP, FACG, AGAF. ... Helicobacter pylori infection rates in duodenal ulcer patients in the United States may be lower than previously estimated. Am ... Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. ...
Helicobacter pylori infection | GutDoes Helicobacter pylori eradication really reduce the risk of gastric cancer at the population level? Zhu Wang, Yang Yu, ... Association of Helicobacter pylori seropositivity with all-cause mortality: fact or fiction? Palaniappan Manickam, Prasad ... as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, ...
"Agreement between Serology and Histology for detection of Helicobacter pylori infection" by Sahar...Conclusion: A substantial agreement was found between serology and histopathology results to detect the H. pylori infection. ... pylori infection. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Pathology and ... To determine the percentage agreement between serology and histology for detection of Helicobacter (H.) ... Agreement between Serology and Histology for detection of Helicobacter pylori infection. Journal of the College of Physicians ...
Effect of Helicobacter pylori infection on blood pressure: a community based cross sectional study | The BMJEffect of Helicobacter.... *Effect of Helicobacter pylori infection on blood pressure: a community based cross sectional study ... Effect of Helicobacter pylori infection on blood pressure: a community based cross sectional study BMJ 2001; 323 :264 ... Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study.BMJ1999;319:1157-1162 ... Prospective relations between Helicobacter pylori infection, coronary heart disease and stroke in middle aged men.Heart1996;75: ...
Helicobacter Pylori Infection - Hello..I was diagnosed with H-Pylori last week, Started the meds 3?... helicobacter pylori infection, infections, vertigo - Answer: You could have an ulcer. That would cause the symptoms. You don't ... Home › Q & A › Questions › Helicobacter Pylori Infection.... Helicobacter Pylori Infection - Hello..I was diagnosed with H- ... helicobacter pylori infection, infections, vertigo, diagnosis. Details:. ... days ago. Supposed to take them for two weeks. , ... Helicobacter Pylori Infection - Hi! I finished the ten days of meds for h pilori on Monday, but I?. Posted 17 Aug 2016 • 0 ...
Control of Helicobacter Pylori Infection by Dietary Supplementation With Lactobacillus Reuteri - No Study Results Posted -...Control of Helicobacter Pylori Infection by Dietary Supplementation With Lactobacillus Reuteri. The recruitment status of this ...
Efficacy and Safety of InSan Bamboo Salt on Improvement of Helicobacter Pylori Infection - Full Text View - ClinicalTrials.govHelicobacter Pylori Infection Dietary Supplement: InSan Bamboo Salt Dietary Supplement: Placebo Phase 2 Phase 3 ... Efficacy and Safety of InSan Bamboo Salt on Improvement of Helicobacter Pylori Infection. The recruitment status of this study ... The investigators measured improvement of Helicobacter pylori infection parameters , including 14C-UBT(Urea breath test), and ... controlled human trial to evaluate the efficacy and safety of InSan Bamboo Salt on improvement of Helicobacter pylori infection ...
Helicobacter pylori infection and gastric cancer - Department of Molecular Biosciences, The Wenner-Gren InstituteHelicobacter pylori infection and gastric cancer. Fill out the form below to send 'Helicobacter pylori infection and gastric ... Send 'Helicobacter pylori infection and gastric cancer' to a friend.. *Your name. *Your email. *Recipient name. *Recipient ...
Helicobacter Pylori Infection and the Risk of Barrett's Oesophagus: A Community-Based Study | GutConclusions: Helicobacter pylori infection and cagA+ status were inversely associated with a new diagnosis of Barrett's ... Helicobacter Pylori Infection and the Risk of Barrett's Oesophagus: A Community-Based Study ... Helicobacter Pylori Infection and the Risk of Barrett's Oesophagus: A Community-Based Study ... Main Measures: Subjects completed direct in-person interviews and antibody testing for Helicobacter pylori and its cagA protein ...
Suggestion against an oral-oral route of transmission for Helicobacter pylori infection: a seroepidemiological study in a rural...Suggestion against an oral-oral route of transmission for Helicobacter pylori infection: a seroepidemiological study in a rural ... Furthermore, multiple logistic regression analysis did not show any risk factor shared by both infections. The findings of this ... were seronegative for both infections, 17 (3.6%) were seropositive for H. pylori, and 155 (33.3%) were seropositive for Epstein ...
Biohit GastroPanel - for diagnosis of atrophic gastritis and Helicobacter pylori infection from Biohit Healthcare |...... for diagnosis of atrophic gastritis and Helicobacter pylori infection from Biohit Healthcare on SelectScience ... Biohit GastroPanel - for diagnosis of atrophic gastritis and Helicobacter pylori infection. Biohit GastroPanel - for diagnosis ... Biohit GastroPanel - for diagnosis of atrophic gastritis and Helicobacter pylori infection. Manufacturer Biohit Healthcare. Be ... such as atrophic gastritis and Helicobacter pylori infection. On the basis of the results of the GastroPanel test panel it is ...
The American Journal of Tropical Medicine and Hygiene | PREVALENCE AND PREDICTORS OF HELICOBACTER PYLORI INFECTION IN CHILDREN...The lowest prevalence in the most remote setting suggests that the infection has been a recent arrival in previously isolated ... Infection with H. pylori among the Penan was less than reported in other low socioeconomic groups. ... To determine the prevalence of Helicobacter pylori antigen carriage in stool in the Penan ethnic minority in Malaysian Borneo, ... Helicobacter pylori infection. N Engl J Med 347 : 1175-1186.. * Frenck RW, Clemens J, 2003. Helicobacter in the developing ...
Relation of Helicobacter pylori Infection to 13-Year Mortality and Incident Ischemic Heart Disease in the Caerphilly...Association of Helicobacter pylori infection with coronary heart disease: study shows association between H pylori infection ... Helicobacter pylori infection and coronary heart disease in the North Glasgow MONICA population. Eur Heart J. 1997;18:1257-1260 ... Helicobacter pylori Helicobacter pylori is a chronic infection of the human stomach that is an established cause of gastritis ... Helicobacter pylori infection does not influence the risk of acute myocardial infarction. Heart. 1996;76:308-311. ...
Helicobacter Pylori Infection | Efficacy of Acetilcysteine in 'Rescue' Therapy for Helicobacter Pylori Infection. Pilot StudyH pylori gastric infection is one of the most ... Helicobacter Pylori Infection research study. What is the ... Helicobacter Pylori Infection , Efficacy of Acetilcysteine in 'Rescue' Therapy for Helicobacter Pylori Infection. Pilot Study ... Helicobacter Pylori Infection. Study Interventions. Interventions can include giving participants drugs, medical devices, ... Inclusion Criteria: - Both genders - Age , 18 years - Persistent infection from Helicobacter pylori, at gastroscopy or 13C urea ...
Helicobacter pylori infection in North-Eastern peninsular Malaysia : evidence for an unusually low prevalence. | Base...The H. pylori infection rate ascertained by microbiologic examination of multiple gastric antral biopsy specimens was 50% 17 of ... The prevalence of Helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia NUD patients, ... Helicobacter pylori infection in North-Eastern peninsular Malaysia : evidence for an unusually low prevalence. R f. 80233 ... The prevalence of Helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia (NUD) patients ...
For what conditions is there evidence-based justification for treatment of Helicobacter pylori infection ? | Base documentaire ...Mots-cl s Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, ... For what conditions is there evidence-based justification for treatment of Helicobacter pylori infection ? R f. 159085 Article ... There is level I evidence supporting the treatment of Helicobacter pylori infection in patients with duodenal or gastric ulcers ... Mots-cl s Pascal : Gastrite, Campylobact riose, Bact riose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bact rie ...
Prevalence of Helicobacter pylori infection in infants and family contacts in a poor Bangladesh community. | Base documentaire...In this study we examined the prevalence of H. pylori infection in the family members of index infants infected with this ... Prevalence of Helicobacter pylori infection in infants and family contacts in a poor Bangladesh community. R f. 120806 Article ... Infection rates were 82% and 91% in family contacts of the infected and noninfected infants respectively, the average infection ... We conclude that in communities with high prevalence of H. pylori infection, there is almost an equal infection rate among the ...
The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel...The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel- ... The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel- ... Objectives: This study aimed to resolve controversy regarding the effects of Helicobacter pylori eradication therapy and H. ... Objectives: This study aimed to resolve controversy regarding the effects of Helicobacter pylori eradication therapy and H. ...
The use of AP-PCR and flaA-RFLP typing to investigate treatment failure in Helicobacter pylori infection... Adamsson, I ... Clinical Microbiology and Infection On the subject. Microbiology Search outside of DiVA. GoogleGoogle Scholar. ... 2000 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 6, no 5, 265-267 p.Article in ...
KAKEN - Research Projects | Molecular biological relationships between oral cavity and upper gastrointestinal tract in...Molecular biological relationships between oral cavity and upper gastrointestinal tract in Helicobacter pylori infection. ... Bovine Milk Inhibits Both Adhesion of Helicobacter Pylon to Sulfatide and Helicobacter pylon-induced Vacuolation of Vero Cells ... Bovine Milk Inhibits Both Adhesion of Helicobacter Pylori to Sulfatide and Helicobacter pylori-induced Vacuolation of Vero ... To analyze the existence of Helicobacter pylori (H. pylori) in the oral cavity, we collected the plaque and saliva in the ...
Helicobacter Pylori Infection | Orange Park Medical CenterLearn more about Helicobacter Pylori Infection at Orange Park Medical Center DefinitionCausesRisk ... T114484/Helicobacter-pylori-infection: Fuccio L, Zagari RM, Eusebi LH. Meta-analysis: Can Helicobacter pylori eradication ... Weyermann M, Rothenbacher D, Brenner H. Acquisition of Helicobacter pylori infection in early childhood: independent ... infection. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114484/Helicobacter-pylori-infection ...
Diagnosis of helicobacter pylori infection with the 13C-urea breath test : analysis by means of gas chromatography with mass...Diagnosis of helicobacter pylori infection with the 13C-urea breath test : analysis by means of gas chromatography with mass ... Diagnosis of helicobacter pylori infection with the 13C-urea breath test : analysis by means of gas chromatography with mass ...
Chapter 151. Helicobacter pylori Infections | Harrison's Principles of Internal Medicine, 18e | AccessPharmacy | McGraw-Hill...Helicobacter pylori Infections." Harrison's Principles of Internal Medicine, 18e Longo DL, Fauci AS, Kasper DL, Hauser SL, ... Helicobacter pylori Infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. Longo D.L., Fauci A.S., ... proportion of gastric Helicobacter infections are due to species other than H. pylori, possibly acquired as zoonoses. Whether ... Helicobacter species can cause disease with clinical features resembling those of Campylobacter infections; these species are ...
Effects of Dietary Heme/Non-heme Iron and Helicobacter Pylori (Hp) Infection on Maternal Iron-deficiency Anemia and Fetal...Infection. Communicable Diseases. Anemia. Anemia, Iron-Deficiency. Deficiency Diseases. Helicobacter Infections. Hematologic ... Helicobacter pylori (Hp) may be the most common bacterial infection worldwide, infecting almost half of people in developed ... Effects of Dietary Heme/Non-heme Iron and Helicobacter Pylori (Hp) Infection on Maternal Iron-deficiency Anemia and Fetal ... The available data on the prevalence of Hp infection in Taiwan population was 54.4%. We all know that infection with Hp is ...
Helicobacter pullorum: Helicobacter pullorum is a bacterium in the Helicobacteraceae family, Campylobacterales order. It was isolated from the liver, duodenum, and caecum of broiler and layer chickens, and from humans with gastroenteritis.CagA: Helicobacter pylori virulence factor CagA (cytotoxin-associated gene A) is a 120–145kDa protein encoded on the 40kb cag pathogenicity island (PAI). H.GastritisGastric mucosal barrier: The gastric mucosal barrier is the property of the stomach that allows it to contain acid.Dodecameric protein: A dodecameric protein has a quaternary structure consisting of 12 protein subunits in a complex. Dodecameric complexes can have a number of subunit 'topologies', but typically only a few of the theoretically possible subunit arrangements are observed in protein structures.Stomach diseaseFetor hepaticusJohn Lykoudis: John Lykoudis (1910 in Missolonghi – 1980) was a general practitioner in Greece who treated patients suffering from peptic ulcer disease with antibiotics long before it was commonly recognized that bacteria were a dominant cause for the disease.ClarithromycinTolevamerAmoxicillinNepean HospitalFerric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.OmeprazoleReactive gastropathy: In gastroenterology, reactive gastropathy, also chemical gastropathy, is an abnormality in the stomach caused by chemicals, e.g.Sodium bismuthateGastrin: Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.Gastric erosion: Gastric erosion occurs when the mucous membrane lining the stomach becomes inflamed. Some drugs, as tablets, can irritate this mucous membrane, especially drugs taken for arthritis and muscular disorders, steroids, and aspirin.Erythromycin breath test: The erythromycin breath test (ERMBT) is a method used to measure metabolism (oxidation and elimination from the system) by a part of the cytochrome P450 system. Erythromycin is tagged with carbon-14 and given as an intravenous injection; after 20 minutes the subject blows up a balloon and the carbon dioxide exhaled that is tagged with carbon-14 shows the activity of the CYP3A4 isoenzyme on the erythromycin.BacitracinLansoprazoleProton-pump inhibitorCombination therapy: Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).Intestinal metaplasia: 200px|right|thumb|Intestinal metaplasia (top middle of image) of the gastric antrum and [[stomach cancer|adenocarcinoma of the stomach (left/centre of image). H&E stain.Thermal cyclerTinidazole
(1/5095) The significance of cagA and vacA subtypes of Helicobacter pylori in the pathogenesis of inflammation and peptic ulceration.
AIMS: To assess the significance of cagA and vacA subtypes of Helicobacter pylori in relation to inflammation and density of bacterial colonisation in vivo within a dyspeptic UK population. METHODS: Dyspeptic patients who were Helicobacter pylori positive had antral samples taken for histology and culture. Gastroduodenal pathology was noted. The grade of bacterial density and inflammation was assessed using the Sydney system. Bacterial DNA was extracted and the vacA alleles and the cagA/gene typed using PCR. RESULTS: 120 patients were studied. There was high rate of cagA positive strains in this population. Bacterial density did not correlate with the presence of peptic ulceration. There was a significant association between cagA positive strains and increased inflammation and bacterial density. The vacA s1 type independently correlated with extensive chronic inflammation but there was no association with bacterial density. The vacA m type did not correlate with extent of inflammation or bacterial density. CONCLUSIONS: The results suggest that cagA is important in the pathogenesis of inflammation and peptic ulceration. These findings are in keeping with the hypothesis that cagA acts as a marker for a cag pathogenicity island which encodes several genes involved in inflammation. The vacA s1 allele correlates with inflammation independently of cagA, possibly through its enhanced ability to produce the vacuolating cytotoxin. (+info)
(2/5095) Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis.
AIM: To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS: In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and histological grading of gastritis. Gastritis was evaluated by visual analogue scales. Quantities of chemokine (IL-8, GRO alpha, ENA-78, RANTES, MCP-1) RT-PCR products were compared with G3PDH products. Each sample was also evaluated for the presence of cagA and ureA mRNA by RT-PCR. RESULTS: mRNA expression of all five chemokines was significantly greater in H pylori positive than in H pylori negative mucosa. In H pylori positive patients, in the antrum C-X-C chemokine mRNA expression was significantly greater in cagA positive patients than in cagA negative patients, but there were no significant differences in C-C chemokine mRNA expression. In H pylori positive patients, chemokine mRNA expression in the corpus was less than in the antrum. In contrast to the antrum, only GRO alpha mRNA expression was significantly greater in cagA positive infection. Polymorphonuclear cell infiltration was correlated with C-X-C chemokine mRNA expression. Significant correlations were also found between bacterial density and C-X-C chemokine mRNA expression. CONCLUSIONS: In H pylori infection, C-X-C chemokines may play a primary role in active gastritis. Infection with cagA positive H pylori induces greater gastric chemokine mRNA expression in the antral mucosa, which may be relevant to the increased mucosal damage associated with cagA positive H pylori infection. (+info)
(3/5095) Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer.
BACKGROUND: Cangshan County of Shandong Province has one of the lowest rates of gastric cancer (GC) in China. While intestinal metaplasia (IM) and dysplasia (DYS) are less common in Cangshan than in areas of Shandong at high risk of GC, these precursor lesions nevertheless affect about 20% of adults age > or = 55. SUBJECTS AND SETTING: In order to evaluate determinants of IM and DYS in Cangshan County, a low risk area of GC a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. METHOD: A dietary interview and measurement of serum Helicobacter pylori antibodies were performed. RESULTS: The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM, and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval [CI] : 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% CI: 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR = 3.2, 95% CI: 1.1-9.2) and IM/DYS (OR = 7.8, 95% CI: 1.3-47.7). On the other hand, consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. CONCLUSIONS: The findings of this study suggest that infection with H. pylori is a risk factor and garlic may be protective, in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC. (+info)
(4/5095) Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease.
OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum. (+info)
(5/5095) Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation.
The Helicobacter pylori VacA toxin plays a major role in the gastric pathologies associated with this bacterium. When added to cultured cells, VacA induces vacuolation, an effect potentiated by preexposure of the toxin to low pH. Its mechanism of action is unknown. We report here that VacA forms anion-selective, voltage-dependent pores in artificial membranes. Channel formation was greatly potentiated by acidic conditions or by pretreatment of VacA at low pH. No requirement for particular lipid(s) was identified. Selectivity studies showed that anion selectivity was maintained over the pH range 4.8-12, with the following permeability sequence: Cl- approximately HCO3- > pyruvate > gluconate > K+ approximately Li+ approximately Ba2+ > NH4+. Membrane permeabilization was due to the incorporation of channels with a voltage-dependent conductance in the 10-30 pS range (2 M KCl), displaying a voltage-independent high open probability. Deletion of the NH2 terminus domain (p37) or chemical modification of VacA by diethylpyrocarbonate inhibited both channel activity and vacuolation of HeLa cells without affecting toxin internalization by the cells. Collectively, these observations strongly suggest that VacA channel formation is needed to induce cellular vacuolation, possibly by inducing an osmotic imbalance of intracellular acidic compartments. (+info)
(6/5095) Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients.
BACKGROUND: Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. The present study was performed to examine the effect of H. pylori infection on serum pepsinogen concentrations in dialysis patients. METHODS: Forty nine patients on dialysis and 48 subjects with no known kidney disease were examined for upper gastroduodenal endoscopy, H. pylori infection and serum concentrations of pepsinogen I and II. The status of H. pylori infection was evaluated from results of a urease test, histology and culture of biopsy specimens of the gastric mucosa. Serum pepsinogen levels were measured by radioimmunoassay. RESULTS: Serum concentrations of pepsinogen I and II were elevated in the dialysis patients in comparison with those in the controls (277.4+/-24.2 vs 52.6+/-4.0 pg/ml, P<0.01 for pepsinogen I, and 30.2+/-2.9 vs 14.9+/-1.3 pg/ml, P<0.01 for pepsinogen II). In both the dialysis patients and controls, those with H. pylori infection had significantly higher concentrations of serum pepsinogen I and II and a lower ratio of pepsinogen I to pepsinogen II than those without infection. Among the controls, 15 of 25 subjects with atrophic gastritis had a pepsinogen I/pepsinogen II ratio < or = 3.0, while only two out of 17 patients on dialysis fell into this range. CONCLUSIONS: We conclude that H. pylori status should be taken into account when serum pepsinogen concentrations are evaluated in dialysis patients. (+info)
(7/5095) Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community.
We assessed the pattern of acquisition and loss of Helicobacter pylori infection in a cohort of 212 children from a biracial community with a homogeneous socioeconomic class. The children were followed over 12 years (1973-1974 to 1985-1986) from childhood to young adulthood. H. pylori status was assessed by the presence of serum IgG antibodies to H. pylori. At ages 7-9, 19% of children had H. pylori infection (40% of blacks vs. 11% of whites; P = .0001); 12 years later, 33% were seropositive. The higher prevalence among blacks remained (P = .0001). During follow-up, 22% of children became infected; the rate of acquisition was fourfold greater among blacks than among whites (P = .001). Over the 12-year period, infection was lost in 50% of whites compared with 4% of blacks who either remained infected or became reinfected. H. pylori infection in childhood is affected by both acquisition and loss of infection in different ethnic groups. This observation is critical for understanding the epidemiology and transmission of H. pylori infection. (+info)
(8/5095) KRAS mutations predict progression of preneoplastic gastric lesions.
Eight hundred sixty-three subjects with atrophic gastritis were recruited to participate in an ongoing chemoprevention trial in Narino, Colombia. The participants were randomly assigned to intervention therapies, which included treatment to eradicate Helicobacter pylori infection followed by daily dietary supplementation with antioxidant micronutrients in a 2 x 2 x 2 factorial design. A series of biopsies of gastric mucosa were obtained according to a specified protocol from designated locations in the stomach for each participant at baseline (before intervention therapy) and at year three. A systematic sample of 160 participants was selected from each of the eight treatment combinations. DNA was isolated from each of these biopsies (n = 320), and the first exon of KRAS was amplified using PCR. Mutations in the KRAS gene were detected using denaturing gradient gel electrophoresis and confirmed by sequence analysis. Of all baseline biopsies, 14.4% (23 of 160) contained KRAS mutations. Among those participants with atrophic gastritis without metaplasia, 19.4% (6 of 25) contained KRAS mutations, indicating that mutation of this important gene is likely an early event in the etiology of gastric carcinoma. An important association was found between the presence of KRAS mutations in baseline biopsies and the progression of preneoplastic lesions. Only 14.6% (20 of 137) of participants without baseline KRAS mutations progressed from atrophic gastritis to intestinal metaplasia or from small intestinal metaplasia to colonic metaplasia; however, 39.1% (9 of 23) with baseline KRAS mutations progressed to a more advanced lesion after 3 years [univariate odds ratio (OR), 3.76 (P = 0.05); multivariate OR adjusted for treatment, 3.74 (P = 0.04)]. In addition, the specificity of the KRAS mutation predicted progression. For those participants with G-->T transversions at position 1 of codon 12 (GGT-->TGT), 19.4% (5 of 17) progressed (univariate OR, 2.4); however, 60.0% (3 of 5) of participants with G-->A transitions at position 1 of codon 12 (GGT-->AGT) progressed (univariate OR, 8.7; P = 0.004 using chi2 test). (+info)
- Background: Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. (clinicaltrials.gov)
- Eradication of H. pylori infection could reduce the occurence or recurrence of these diseases. (clinicaltrials.gov)
- In recent years, the concept of sequential therapy has been advocated in the treatment of H. pylori infection. (clinicaltrials.gov)
- The investigators performed a 4-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of InSan Bamboo Salt on improvement of Helicobacter pylori infection. (clinicaltrials.gov)
- The investigators measured improvement of Helicobacter pylori infection parameters , including 14C-UBT(Urea breath test), and subjects' symptoms, and monitored their blood pressure. (clinicaltrials.gov)
- OBJECTIVE: The vacuolating cytotoxin of Helicobacter pylori ( H. pylori ) is encoded by vacA , of which allelic variation has been described. (ebscohost.com)
- Clinicians who are treating patients with uncomplicated dyspepsia should acquire a serum Helicobacter pylori titer and prescribe eradication therapy if the titer is positive. (ebscohost.com)
- Objective: H. pylori infection and gastrointestinal symptoms may occur in patients with or without peptic ulcer disease (PUD). (ebscohost.com)
- Discusses the mechanisms of action of Helicobacter (H.) pylori. (ebscohost.com)
- It mentions about referral guidelines for endoscopy and treatment of Helicobacter Pylori infection. (ebscohost.com)
- Helicobacter pylori infection in North-Eastern peninsular Malaysia : evidence for an unusually low prevalence. (ehesp.fr)
- The prevalence of Helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia (NUD) patients, and in the general adult population. (ehesp.fr)
- The H. pylori infection rate ascertained by microbiologic examination of multiple gastric antral biopsy specimens was 50% (17 of 34) in duodenal ulcer (DU), 5% (1 of 22) in gastric ulcer, and 9% (15 of 159) in NUD patients. (ehesp.fr)
- H. pylori infection is relatively uncommon and does not appear to be the predominant factor in the pathogenesis of peptic ulcer disease in the area. (ehesp.fr)
- The authors aimed to investigate whether the exposure to different forms of tobacco influences upper gastrointestinal symptoms, histology and frequency of Helicobacter. (ebscohost.com)