Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.Silver-Russell Syndrome: Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.Dwarfism: A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.Beckwith-Wiedemann Syndrome: A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.Hair Follicle: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.Genomic Imprinting: The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)Body Height: The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.Insulin-Like Growth Factor II: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety Disorders: Persistent and disabling ANXIETY.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Depressive Disorder, Major: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Phobic Disorders: Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.Child Development Disorders, Pervasive: Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)Substance-Related Disorders: Disorders related to substance abuse.

*  Pet Medical Conditions
... prior to a lump or abnormal growth developing. Once developed, the abnormal growth is called a neoplasm or tumor. Tumors can be ... Epilepsy is a disorder of the brain causing physical attacks that come on suddenly and without control. The cat may be ... Other insulin-resistant disorders, e.g. Pancreatitis. • Obesity. • Certain medications. Between 0.2% to 1.0% of dogs develop ... Epilepsy is often an inherited condition and is the most common brain disorder in dogs. The incidence is much higher in some ...
*  Short stature | Nicklaus Children's Hospital
TREATMENT WITH GROWTH HORMONE INJECTIONS. If your child has no or low levels of growth hormone, your provider may talk about ... Cancer & Blood Disorders Center * Cardiology and Cardiovascular Surgery * Clinical Research * Craniofacial Center ... The growth curve shows that the child will be a very short adult. Using growth hormone will usually increase the child's final ... Poor growth of a baby while in the womb (. intrauterine growth restriction. ) or small for gestational age. ...
*  Short Children and Normal Growth
Growth hormone treatment of non-growth hormone-deficient growth disorders. Endocrinol Metab Clin North Am, March 2007; 36(1): ... Growth hormone is required for normal growth, and children with growth hormone deficiency are short, often look younger than ... Treatments for growth hormone deficiency include growth hormone replacement. Other conditions for which growth hormone is ... children with growth hormone deficiency will have a slow rate of growth and they will have a growth curve that falls away from ...
*  Karen Tsuchiya, MD - Faculty - UW Laboratory Medicine
My main interest is implementing new technology in the clinical laboratory for the diagnosis of pediatric disorders. ... duplications of NSD1 causes growth retardation. Submitted to Molecular Syndromology. [Karger] ...
*  Growth Disorders
A growth disorder, however, means that a kid has abnormal growth - for example, growing a lot slower or a lot faster than other ... A growth disorder, however, means that a kid has abnormal growth - for example, growing a lot slower or a lot faster than other ... Hormones and Growth Disorders. One of the glands in your body is called the pituitary gland (say: pih-TOO-ih-tare-ee). It's ... What's a Growth Disorder?. Everyone grows and matures differently. You may be taller than your best friend in fourth grade. But ...
*  What Is a Growth Disorder?
... but your child's growth seems to be lagging behind. Could a growth disorder be the cause? ... Growth disorders include:. Failure to thrive, which isn't a specific growth disorder itself, but can be a sign of an underlying ... Diagnosing a Growth Disorder. The tests a doctor may recommend to detect a growth disorder depend on the findings at each step ... Treating a Growth Disorder. Although the treatment of a growth problem usually isn't urgent, earlier diagnosis and treatment ...
*  Gene Therapy Could Cure Genetic Growth Disorder
... new gene therapy has been developed by researchers at the Vanderbilt University that could be the answer to a genetic disorder ... called Isolated Growth Hormone Deficiency type II (IGHD-II). ... Gene Therapy Could Cure Genetic Growth Disorder. by Medindia ... IGHD-II is a dominant negative disorder, which is caused by a defective form of human growth hormone that not only can't kindle ... Achondroplasia is a rare genetic disorder of bone growth that causes short-limbed dwarfism. It occurs due to mutations in a ...
*  Hybrid growth disorders - Wikipedia
However, a hybrid growth disorder is not caused by cancer. Hybrid growth disorders are exhibited among a variety organisms, ... Hybrid growth disorders refer to reduced growth or overgrowth in an organism that is a hybrid of two different species. In some ... Hybrid growth disorders may be referred to as a growth dysplasia, especially when resulting in overgrowth, although this ... This would also explain why hybrid growth disorders often appear to affect one sex more than the other. Similarly, a study of ...
*  Hair Growth and Disorders, Book by Ulrike Blume-Peytavi (Paperback) |
Buy the Paperback Book Hair Growth and Disorders by Ulrike Blume-Peytavi at, Canada's largest bookstore. + Get Free ... Hair Growth and Disorders. EditorUlrike Blume-Peytavi, David A. Whiting, Ralph M. Trüeb. Paperback , October 14, 2010. ... Title:Hair Growth and DisordersFormat:PaperbackDimensions:590 pages, 10.24 × 7.6 × 0 inPublished:October 14, 2010Publisher: ... The content is divided into three sections: basic aspects of hair growth; hair and scalp disorders; and fotoepilation, surgery ...
*  RNA interference therapy heals growth deficiency disorder in a live animal
IGHD-II is what geneticists call a dominant negative disorder. It is caused by a defective form of human growth hormone that ... RNA interference therapy heals growth deficiency disorder in a live animal. 19.12.2007 ... The cells that produce growth hormone have special receptors that signal the cells to release their stocks of growth hormone. ... defective human growth hormone not only stunted their growth but actually killed the cells in the pituitary that produce growth ...
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*  PPP: Child Growth & Development || Hearing Disorders || What causes hearing disorders
Some children with hearing disorders can hear a little, while others hear nothing at all. Some children with hearing disorders ... One reason for such behavior could be a disorder such as Attention Deficit Disorders (ADD). A second reason could be discipline ... Some children with hearing disorders can hear a little, while others hear nothing at all. Some children with hearing disorders ... Hearing Disorders. Authors: Saraswathy Ramamoorthy with Judith A. Myers-Walls, PhD, CFLE. There are several types of hearing ...
*  Autism Spectrum Disorder: Embodying Development For Growth - Special Needs Resource
... glance at the common symptomology that links across the spectrum of children and adults diagnosed with Autism Spectrum Disorder ... Autism Spectrum Disorder: Embodying Development For Growth. Autism, Featured Topics April 12, 2017April 12, 2017 admin ... and comorbid disorders such as obsessive compulsive disorder and attention deficit disorder, to name a few. ... EMPOWERING STRATEGIES FOR GROWTH. When you decide what factors, stated above, play into your experience with an individual ...
*  Panic Disorders Market- Global Industry Growth, Trends and Forecast | Jan 11, 2018 - ReleaseWire
Panic disorders may last for 5-10 minutes, but it can linger for hours. If it is left untreated, panic disorders progress to ... Panic disorders diagnosed in patients who experience spontaneous attacks and preoccupied with the anxiety of a recurring panic ... Panic disorders usually appear in adolescents and rarely observed in children's. Treatment includes psychological therapy, ... Panic Disorders Market- Global Industry Growth, Trends and Forecast. Panic disorder is an intensive surge of fear and anxiety. ...
*  List of Endocrine Disorders | Thyroid & Endocrine System Diseases
List of all possible Endocrine disorders and diseases affecting the Endocrine System. The endocrine system is a network of ... growth disorders, sexual dysfunction, and a host of other hormone-related disorders. ... List of all possible Endocrine disorders and diseases affecting the Endocrine System. The endocrine system is a network of ... Diabetes mellitus type 2 is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance ...
*  Thiazolidinedione
Growth Disorders * Human Growth Hormone Geriatric Medicine * Medications Associated with Unintentional Weight Loss ... Rosiglitazone stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type ... thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription ... thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription ...
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Growth Disorders * Human Growth Hormone Geriatric Medicine *Medications Associated with Unintentional Weight Loss ...
*  Neurological Disorder Drugs Market - Europe Industry Analysis, Size, Share, Growth, Trends, and
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*  Frontiers | Neural Stem Cell Regulation, Fibroblast Growth Factors, and the Developmental Origins of Neuropsychiatric Disorders...
Disorders that begin in childhood such as autism, language disorders or mental retardation as well as adult-onset mental ... Disorders that begin in childhood such as autism, language disorders or mental retardation as well as adult-onset mental ... brain-derived growth factor (BDNF) and fibroblast growth factors (FGF), all of which have been shown to play important roles in ... brain-derived growth factor (BDNF) and fibroblast growth factors (FGF), all of which have been shown to play important roles in ...
*  Growth hormone treatment improves symptoms of metabolic disorder in postmenopa...( Researchers in Sweden have discovered t...)
Growth,hormone,treatment,improves,symptoms,of,metabolic,disorder,in,postmenopausal,women,medicine,medical news today,latest ... Typically GH is known for its importance in the growth of a child...Dr. Gudmundur Johannsson and his research team at the ... Researchers in Sweden have discovered that growth hormone (GH) treatme... ... Growth factor grows stem cells that help heal hearts. 2. Growth hormone, sex steroid combination not ready for prime time. 3. ...
*  Fetal growth and the lifetime risk of generalized anxiety disorder - Vasiliadis - 2010 - Depression and Anxiety - Wiley Online...
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*  PPP: Child Growth & Development || What are Some Types of Speech & Language Disorders
Voice disorders. A voice disorder happens because the vocal cords that produce sound are damaged. The vocal cords are the ... Voice disorders are sometimes called "voice abuse." Voice disorders in children can be corrected with speech therapy. In speech ... What are Some Types of Speech and Language Disorders. Authors: Saraswathy Ramamoorthy with Judith A. Myers-Walls, PhD, CFLE. ... Articulation disorders. Articulation means making sounds and words. To do this, the lips, teeth, tongue, jaw, and palate (roof ...
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Idiopathic short statureAlan Beckwith: Alan Beckwith is an American actor born in Tyrone, Pennsylvania on January 2, 1952. Graduated from high school in 1969 & Penn State University in 1972 with a B.Dwarfism: Dwarf}}Beckwith–Wiedemann syndromeHair follicle nevus: Hair follicle nevus (also known as a "Vellus hamartoma") is a cutaneous condition that presents as a small papule from which fine hairs protrude evenly from the surface.Waterladder pumpInsulin-like growth factor II IRESBipolar disorderMental disorderSocial anxiety disorderSchizophreniaBrexpiprazoleAdult attention deficit hyperactivity disorderRelationship obsessive–compulsive disorder: In psychology, relationship obsessive–compulsive disorder (ROCD) is a form of obsessive-compulsive disorder focusing on intimate relationships (whether romantic or non-romantic). Such obsessions can become extremely distressing and debilitating, having negative impacts on relationships functioning.Oneirology: Oneirology (; from Greek [oneiron, "dream"; and -λογία], ["the study of") is the scientific study of [[dream]s. Current research seeks correlations between dreaming and current knowledge about the functions of the brain, as well as understanding of how the brain works during dreaming as pertains to memory formation and mental disorders.Focus on Autism and Other Developmental Disabilities: Focus on Autism and Other Developmental Disabilities is a peer-reviewed academic journal covering the field of special education. The editors-in-chief are Alisa K.Claustrophobia: Claustrophobia is the fear of having no escape and being in closed or small space or room It is typically classified as an anxiety disorder and often results in panic attack, and can be the result of many situations or stimuli, including elevators crowded to capacity, windowless rooms, and even tight-necked clothing. The onset of claustrophobia has been attributed to many factors, including a reduction in the size of the amygdala, classical conditioning, or a genetic predisposition to fear small spaces.Relationship Development Intervention: Relationship Development Intervention (RDI) is a trademarked proprietary treatment program for autism spectrum disorders (ASD), based on the belief that the development of dynamic intelligence is the key to improving the quality of life for individuals with autism. The program's core philosophy is that individuals with autism can participate in authentic emotional relationships if they are exposed to them in a gradual, systematic way.DSM-IV Codes (alphabetical): __FORCETOC__Substance-related disorder

(1/1579) Pathological changes in chickens, ducks and turkeys fed high levels of rapeseed oil.

Rations containing 25% of either regular rapeseed oil (36% erucic acid), Oro rapeseed oil (1.9% erucic acid), soybean oil or a mixture of lard and corn oil were fed to chickens, ducks and turkeys. The regular rapeseed oil ration caused growth depression, increased feed conversion and anemia in all species. All the ducks and some of the chickens fed the regular rapeseed oil ration died. These dead birds were affected with hydropericardium and ascites. No deaths in the turkeys could be attributed to the regular rapeseed oil ration but some turkeys fed this ration had degenerative foci characterized by infiltrations of histiocytic and giant cells in the myocardium. Severe fatty change in the heart, skeletal muscles, spleen and kidney was found at an early age in all birds fed the regular rapeseed oil ration. Less severe fatty change but no other lesions were found in birds fed the Oro rapeseed oil and soybean oil rations.  (+info)

(2/1579) Changes in body composition and leptin levels during growth hormone (GH) treatment in short children with various GH secretory capacities.

OBJECTIVE: The aim of this study was to follow changes in body composition, estimated by dual-energy X-ray absorptiometry (DXA), in relation to changes in leptin during the first year of GH therapy in order to test the hypothesis that leptin is a metabolic signal involved in the regulation of GH secretion in children. DESIGN AND METHODS: In total, 33 prepubertal children were investigated. Their mean (S.D.) chronological age at the start of GH treatment was 11.5 (1.6) years, and their mean height was -2.33 (0.38) S.D. scores (SDS). GH was administered subcutaneously at a daily dose of 0.1 (n=26) or 0.2 (n=7) IU/kg body weight. Ten children were in the Swedish National Registry for children with GH deficiency, and twenty-three children were involved in trials of GH treatment for idiopathic short stature. Spontaneous 24-h GH secretion was studied in 32 of the children. In the 24-h GH profiles, the maximum level of GH was determined and the secretion rate estimated by deconvolution analysis (GHt). Serum leptin levels were measured at the start of GH treatment and after 10 and 30 days and 3, 6 and 12 months of treatment. Body composition measurements, by DXA, were performed at baseline and 12 months after the onset of GH treatment. RESULTS: After 12 months of GH treatment, mean height increased from -2.33 to -1.73 SDS and total body fat decreased significantly by 3.0 (3.3)%. Serum leptin levels were decreased significantly at all time points studied compared with baseline. There was a significant correlation between the change in total body fat and the change in serum leptin levels during the 12 months of GH treatment, whereas the leptin concentration per unit fat mass did not change. In a multiple stepwise linear regression analysis with 12 month change in leptin levels as the dependent variable, the percentage change in fat over 12 months, the baseline fat mass (%) of body mass and GHt accounted for 24.0%, 11.5% and 12.2% of the variability respectively. CONCLUSIONS: There are significant correlations between changes in leptin and fat and endogenous GH secretion in short children with various GH secretory capacities. Leptin may be the messenger by which the adipose tissue affects hypothalamic regulation of GH secretion.  (+info)

(3/1579) Separate and joint effects of micronutrient deficiencies on linear growth.

Recent studies have investigated the effect of micronutrient deficiencies on growth stunting, with special attention toward the effect of zinc, iron, vitamin A and iodine deficiencies. In Mexico, the prevalence of growth stunting in children <5 y old is approximately 24%; it is higher in rural areas and lower in urban areas. In an initial study, the effect of zinc and/or iron supplementation on linear growth was investigated in a longitudinal, placebo-controlled design. After 12 mo of supplementation, there was no difference between the groups supplemented with zinc, iron or zinc plus iron and the placebo group. At baseline, 82% of the children in this study were deficient in at least two out of the five micronutrients that were determined, and 73% were anemic. In another study, a mixture of those micronutrients that were documented to be lacking in Mexican children was formulated in a supplement and given to Mexican children over a period of 12 mo in a longitudinal, placebo-controlled, supplementation design. Children in the low and medium socioeconomic status grew about 1 cm more than similar children in the placebo group. This difference was not found in children of high socioeconomic status. It is suggested that, in most cases, growth stunting is associated with marginal deficiencies of several micronutrients and that in populations with multiple micronutrient deficiencies, the effect on linear growth of supplementation with single nutrients will not be significant. Supplementation with multiple micronutrients is expected to be more effective, but even in that case the actual increment in height was less than the expected potential increment.  (+info)

(4/1579) Burden of infection on growth failure.

The high prevalence of infections among children living in poor areas of developing countries impairs linear growth in these populations. Acute, invasive infections, which provoke a systemic response (e.g., dysentery and pneumonia), and chronic infections, which affect the host over a sustained period (e.g., gut helminth infections), have a substantial effect on linear growth. Such infections can diminish linear growth by affecting nutritional status. This occurs because infections may decrease food intake, impair nutrient absorption, cause direct nutrient losses, increase metabolic requirements or catabolic losses of nutrients and, possibly, impair transport of nutrients to target tissues. In addition, induction of the acute phase response and production of proinflammatory cytokines may directly affect the process of bone remodeling that is required for long bone growth. Infection of cells directly involved in bone remodeling (osteoclasts or osteoblasts) by specific viruses may also directly affect linear growth. Many interventions are possible to diminish the effect of infection on growth. Prevention of disease through sanitation, vector control, promotion of breast-feeding and vaccination is crucial. Appropriate treatment of infections (e.g., antibiotics for pneumonia) as well as supportive nutritional therapy (again including breast-feeding) during and after recovery, is also important. Targeted therapeutic interventions to decrease the prevalence of gut helminth infections may also be appropriate in areas in which such infections are widespread. Such interventions are of public health benefit not only because they reduce the incidence or severity of infections, but also because they decrease the long-term detrimental effect of malnutrition on populations.  (+info)

(5/1579) Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

Glial cell line-derived neurotrophic factor (GDNF) and a related protein, neurturin (NTN), require a GPI-linked coreceptor, either GFR alpha1 or GFR alpha2, for signaling via the transmembrane Ret tyrosine kinase. We show that mice lacking functional GFR alpha2 coreceptor (Gfra2-/-) are viable and fertile but have dry eyes and grow poorly after weaning, presumably due to malnutrition. While the sympathetic innervation appeared normal, the parasympathetic cholinergic innervation was almost absent in the lacrimal and salivary glands and severely reduced in the small bowel. Neurite outgrowth and trophic effects of NTN at low concentrations were lacking in Gfra2-/- trigeminal neurons in vitro, whereas responses to GDNF were similar between the genotypes. Thus, GFR alpha2 is a physiological NTN receptor, essential for the development of specific postganglionic parasympathetic neurons.  (+info)

(6/1579) Cloning and expression of a novel chicken sulfotransferase cDNA regulated by GH.

We have used mRNA differential display to compare gene expression in normal and GH receptor-deficient dwarf chickens, and report here the characterization of one differentially expressed gene, which shows significant sequence identity to the sulfotransferase gene family. Partial cDNA clones were isolated from a chicken liver cDNA library and an additional sequence was obtained using 5' rapid amplification of cDNA ends. A complete cDNA probe hybridizes to three transcripts (2.4, 2.0 and 1.45 kb) on Northern blots of chicken liver RNA, which differ in the length of the 3' untranslated region. All three transcripts are expressed at higher levels in normal vs dwarf chickens, as expected for a GH-regulated gene. The expression of this sulfotransferase mRNA was also detected in skeletal muscle, but not other tissues. The administration of GH to chickens increased the hepatic expression within 1 h, suggesting this sulfotransferase could be directly regulated by GH. Sulfotransferase activity, using estradiol or corticosterone as substrate, is detected in cells transfected with an expression vector containing the full-length cDNA. The sequence of this sulfotransferase does not show significant similarity with any subfamily of the sulfotransferases and its endogenous substrate is presently unknown. However, we speculate that GH activation of sulfotransferase activity could play a role in reducing concentrations of growth-antagonistic steroid hormones in GH target tissues. These results demonstrate the usefulness of differential display in this model system to identify genes that play a role in mediating GH action.  (+info)

(7/1579) Growth hormone treatment in young children with Down's syndrome: effects on growth and psychomotor development.

BACKGROUND: Learning disability and short stature are cardinal signs of Down's syndrome. Insulin-like growth factor I (IGF-I), regulated by growth hormone (GH) from about 6 months of age, may be involved in brain development. AIMS: To study long term effects of GH on linear growth and psychomotor development in young children with Down's syndrome. Study design-Fifteen children with Down's syndrome were treated with GH for three years from the age of 6 to 9 months (mean, 7.4). Linear growth, psychomotor development, skeletal maturation, serum concentrations of IGF-I and its binding proteins (BPs), and cerebrospinal fluid (CSF) concentrations of IGF-II were studied. RESULTS: The mean height of the study group increased from -1.8 to -0.8 SDS (Swedish standard) during treatment, whereas that of a Down's syndrome control group fell from -1.7 to -2.2 SDS. Growth velocity declined after treatment stopped. Head growth did not accelerate during treatment. No significant difference in mental or gross motor development was found. The low concentrations of serum IGF-I and IGFBP-3 became normal during GH treatment. CONCLUSIONS: GH treatment results in normal growth velocity in Down's syndrome but does not affect head circumference or mental or gross motor development. Growth velocity declines after treatment stops.  (+info)

(8/1579) Generalised uridine diphosphate galactose-4-epimerase deficiency.

The generalised form of epimerase deficiency galactosaemia has been described in only two children from unrelated families. Their progress is reported and three other affected children from these families are described. The initial presentation was similar to classic galactosaemia. Despite treatment all have shown poor growth and moderate learning difficulties. Three have sensorineural deafness and four have pronounced dysmorphic features. The two older female patients have normal pubertal development.  (+info)

  • Etiology
  • Etiology of panic disorders can be neurochemical dysfunction of decreased gamma-amino butyric acidergic tone, diminished benzodiazepine receptor function, autonomic imbalance, disturbances in serotonin, and increased adenosine receptor function. (
  • We will discuss here stem cell biology, signaling factors that affect these cells, and the potential contribution of these processes to the etiology of neuropsychiatric disorders. (
  • menstrual
  • Puberty is the stage of your life when sexual development happens, like breast development and menstrual periods in girls and growth of the penis and testicles in boys. (
  • clinical
  • Published in today in the March issue of The Journal of Clinical Endocrinology & Metabolism, these findings demonstrate the important role growth hormone treatment may play in reducing serious metabolic conditions, such as diabetes and heart disease. (
  • Epstein's Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. (
  • The term fibromatosis refers to a group of soft tissue tumors which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence. (
  • The syndrome is a rare clinical disorder. (
  • CAGR
  • The future of Panic Disorders market is anticipated to grow at double CAGR during the forecast period. (
  • This report on the neurological disorder drugs market also provides the compound annual growth rate (CAGR %) for each market segment for the forecast period from 2016 to 2024, considering 2015 as the base year. (
  • children
  • But some children who are under the 3rd percentile or over the 97th percentile, or who are growing a lot slower or faster than most other kids, may have a growth problem. (
  • But others may have an actual growth disorder, which is any type of problem that prevents kids from meeting realistic expectations of growth , from failure to gain height and weight in young children to short stature or delayed sexual development in teens. (
  • Hair Disorders in Children. (
  • Some children with hearing disorders can hear a little, while others hear nothing at all. (
  • Some children with hearing disorders may be able to hear sounds well, but they will not be able to understand what they are hearing. (
  • This article will glance at the common symptomology that links across the spectrum of children and adults diagnosed with Autism Spectrum Disorder (ASD). (
  • I am proud to say that while that is a loaded question with many variabilities, I respond by asking, "what would you like to have happen" "what are you hoping your children or your family member can achieve/experience," and with this information together we can find important, creative, and whole body interventions to support growth and development. (
  • For children surgery is particularly difficult, given the potential for growth disorders. (
  • Pediatric endocrinologists are usually the primary physicians involved in the medical care of infants and children with intersex disorders. (
  • National Cooperative Growth Study (NCGS) is the largest observational database in the U.S. of children with growth disorders. (
  • depends
  • This suggests that the extent of a disorder depends on the combination of parental species and their respective sexes, as demonstrated by the Vrana study. (
  • It is also becoming clear that mitosis and apoptosis are toggled or linked in some way and that the balance achieved depends on signals received from appropriate growth or survival factors. (
  • Additionally
  • In terms of treatment/management for those with Mulibrey nanism should have routine medical follow-ups, additionally the following can be done: Growth hormone treatment Regular pelvic exams Pericardiectomy Worldwide, it has been documented in 110 persons, 85 of them Finnish. (
  • percentile
  • If you are in the 50th percentile on the growth chart, it means half of the kids your age are taller than you are and half are shorter. (
  • Most kids whose heights are between the 3rd percentile and the 97th percentile and who are growing at a steady rate are considered to have normal growth. (
  • insufficient
  • Serotonergic model of panic disorders suggests that insufficient or exaggerated receptor response to synaptic serotonin. (
  • On the other hand, insufficient nutrition to mare or foal can cause stunted growth and other health problems for the foal as it gets older. (
  • anxiety
  • Panic disorder is an intensive surge of fear and anxiety. (
  • Panic disorders diagnosed in patients who experience spontaneous attacks and preoccupied with the anxiety of a recurring panic disorder. (
  • According to Anxiety and Depression Association of America, 2-3% of Americans always experience panic disorders in a given year. (
  • genes
  • For example, candidate susceptibility genes for schizophrenia, autism and major depression include the signaling molecule Disrupted In Schizophrenia-1 (DISC-1), the homeodomain gene engrailed-2 (EN-2), and several receptor tyrosine kinases, including brain-derived growth factor and fibroblast growth factors, all of which have been shown to play important roles in NSCs or neuronal precursors. (
  • disease
  • With both constitutional growth delay and familial short stature, kids and families need to be reassured that the child does not have a disease or medical condition that poses a threat to health or that requires treatment. (
  • The disorder segment has been sub-segmented into Epilepsy, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, Cerebrovascular disease and others. (
  • often
  • If they don't, daily shots of growth hormone can often help them grow to be normal-sized adults. (
  • One or both parents or other close relatives often had a similar "late-bloomer" growth pattern. (
  • This would also explain why hybrid growth disorders often appear to affect one sex more than the other. (
  • episcleritis - most often a mild, inflammatory disorder of the 'white' of the eye unassociated with eye complications in contrast to scleritis, and responding to topical medications such as anti-inflammatory drops. (
  • rare
  • From the reviews:"The book covers the full range of topics from basic principles of hair biology to rare genodermatoses that manifest as hair disorders. (
  • Spondylocostal dysostosis is a rare, heritable axial skeleton growth disorder. (
  • puberty
  • Kids with familial short stature still have growth spurts and enter puberty at normal ages, but they usually will only reach a height similar to that of their parents. (
  • Drugs
  • This research report provides a detailed analysis of the neurological disorder drugs market and helps understand the various driving factors for the growth of the market. (
  • Market dynamics factors such as market attractiveness analysis have also been explained in order to deliver a thorough analysis of the overall competitive scenario of the Europe neurological disorder drugs market. (
  • The neurological disorder drugs market has been segmented by disorder, by drug class, by distribution channel and by countries. (
  • This elaborate executive summary provides a glimpse into the present scenario of the Europe neurological disorder drugs market, which includes a market snapshot that provides overall information of various segments and sub-segments. (
  • The executive summary also provides overall information and data analysis of the Europe neurological disorder drugs market with respect to market segments based on disorder, drug class, distribution channel as well as geographic regions. (
  • The market for neurological disorder drugs has been extensively analyzed based on their usefulness, effectiveness, sales revenue and geographic presence. (
  • The report also profiles major players in the neurological disorder drugs market based on various attributes such as company overview, financial overview, business strategies, product portfolio and recent developments. (
  • function
  • In order to expand our understanding of these origins, the National Institute of Mental Health (NIMH) is investing in studies of developmental neurobiology, choosing one of its strategies to be the support of "research to improve our basic understanding of the development, structure, and function of neural circuits, with a focus on those most relevant to mental disorders" ( NAMHC, 2008 ). (
  • Reduced thoracic size can restrict lung growth and reduce pulmonary function. (
  • treatment
  • The present treatment for IGHD-III consists of daily injections of growth hormone until the patients reach their adult height. (
  • Due lack of effective treatment for panic disorders they are a huge demand for medicinal treatment. (
  • Because of this reason, key market players are majorly focused on R&D to develop a safe and effective treatment for panic disorders. (
  • Due to lack of awareness and effective evidence-based medicinal treatment, the growth of the panics disorders market is restrained. (
  • Researchers in Sweden have discovered that growth hormone (GH) treatment may result in the reduction of multiple metabolic disorders associated with abdominal obesity in postmenopausal women. (
  • The next most common problem is growth disorders, especially those amenable to growth hormone treatment. (
  • Started in 1985, NCGS was a long term longitudinal study following patients undergoing growth hormone treatment in North America (the U.S. and Canada). (
  • common
  • Although it's common for newborns to lose a little weight in the first few days, failure to thrive is a condition in which some infants continue to show slower-than-expected weight gain and growth. (
  • Panic disorders more common in women than men. (
  • usually
  • Kids who are higher or lower than this on the growth chart are usually normal, too. (
  • It is usually injection and prominence of the superficial blood vessels of the conjunctiva, or sclera, which may be caused by disorders of these or adjacent structures. (
  • type
  • In some sense, it is a type of hybrid dysgenesis when the growth disorder proves deleterious, making it the opposite of heterosis or hybrid vigour. (
  • causes
  • Your doctor or an endocrinologist will look for signs of the many possible causes of short stature and growth failure. (
  • adults
  • Typically, GH is known for its importance in the growth of a child, but it also has powerful metabolic effects in adults. (