Giant Lymph Node Hyperplasia
Lymph Nodes
Human herpesvirus 8 in hematologic diseases. (1/254)
Human herpesvirus type 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV) is a new member of the g-herpesvirus family. It is an unusual herpesvirus in that it carries a large number of genes that encode oncoproteins or cell signaling proteins. In addition to being the causative agent of both HIV-associated and non-HIV-associated Kaposi's sarcoma this DNA tumor virus has been implicated in the pathogenesis of several diseases. These include multiple myeloma (MM), Waldenstom's macroglobulinemia (WM), multicentric Castleman's disease (MCD), body cavity-based lymphoma (BCBL), and various other conditions such as sarcoidosis and pemphigus. While the causative role of the viral infection is fairly certain in the development of BCBL and multicentric Castleman's disease, HHV-8 may act through a different mechanism to induce plasma cell malignancies. It has been suggested though the finding is still controversial - that infection of bone marrow stromal dendritic cells by HHV-8 might be a key factor in the etiology and pathogenesis of monoclonal gammopathies. The aim of this review is to provide a short introduction into the tumorigenic potential of HHV-8 as well as to detail the available data and possible mechanisms on the involvement of this virus in different hematologic diseases. (+info)Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (2/254)
Human herpesvirus 8 (HHV-8) infection has been implicated in the etiology of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), three diseases that frequently develop in immunocompromised, human immunodeficiency virus-positive individuals. One hypothesis that would account for different pathological manifestations of infection by the same virus is that viral genes are differentially expressed in heterogeneous cell types. To test this hypothesis, we analyzed the localization and levels of expression of two viral genes expressed in latent and lytic infections and the viral homologue of interleukin-6 (vIL-6). We show that PEL parallels KS in the pattern of latent and lytic cycle viral gene expression but that the predominant infected cell type is a B cell. We also show that MCD differs from KS not only in the infected cell type (B-cell and T-cell lineage) but also in the pattern of viral gene expression. Only a few cells in the lesion are infected and all of these cells express lytic-cycle genes. Of possibly greater significance is the fact that in a comparison of KS, PEL, and MCD, we found dramatic differences in the levels of expression of vIL-6. Interleukin-6 is a B-cell growth and differentiation factor whose altered expression has been linked to plasma cell abnormalities, as well as myeloid and lymphoid malignancies. Our findings support the hypothesis that HHV-8 plays an important role in the pathogenesis of PEL and MCD, in which vIL-6 acts as an autocrine or paracrine factor in the lymphoproliferative processes common to both. (+info)Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. (3/254)
Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) of HHV-8 encoded by ORF73 to study the distribution of the cell types latently infected by HHV-8 in patch, plaque, and nodular KS, MCD, and PEL. In early KS, HHV-8 is present in <10% of cells forming the walls of ectatic vessels. In nodular KS, HHV-8 is present in cells surrounding slit-like vessels and in >90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in mantle zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8. (+info)Kaposi's sarcoma-associated herpesvirus infection in the lung in multicentric Castleman's disease. (4/254)
A 32-year-old female was admitted for evaluation of multiple infiltrates on a chest radiograph. A diagnosis of multicentric Castleman's disease was made on the basis of typical clinical manifestations. Transbronchial lung biopsy (TBLB) revealed histological findings reported in lymphocytic interstitial pneumonia. Both the polymerase chain reaction and in situ hybridization with a probe specific for Kaposi's sarcoma-associated herpesvirus (KSHV) sequences demonstrated the presence of KSHV in the TBLB sample. (+info)Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. (5/254)
The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodeficiency virus (HIV)-negative patients with MCD, and in bone marrow stromal cells of patients with multiple myeloma. Considering these data, we investigated the presence of HHV-8 in 18 patients with POEMS syndrome (9 with MCD), by nested polymerase chain reaction (N-PCR) to detect DNA sequenses in various cells and tissues obtained by biopsy or at autopsy (13 patients, of whom 7 had MCD), and by an immunofluorescence assay to detect anti-HHV-8 IgG antibodies in blood (18 patients, of whom 9 had MCD). Detection of HHV-8 DNA was performed using three different N-PCR, targeting nonoverlapping regions in open reading frame (ORF) 25 and ORF26. Seven of 13 (54%) POEMS patients had HHV-8 DNA sequences in their tissues, as assessed by all three N-PCR, and 9 of 18 (50%) had circulating anti-HHV-8 antibodies. HHV-8 was mainly detected in the subset of POEMS patients with MCD (6 of 7 [85%] for DNA sequences; 7 of 9 [78%] for antibodies). The percentage of positive N-PCR was higher in lymph nodes than in bone marrow samples (P <.02). Sequencing of amplicons showed a homogeneous restricted variability in the ORF26 region, characteristic of the minority subgroup B defined by Zong, and responsible for isoleucine and glycine substitutions at amino acid positions 134 and 167. These findings strongly suggest an association of HHV-8 infection with POEMS syndrome-associated MCD. (+info)Treatment of multicentric Castleman's disease complicated by the development of non-Hodgkin's lymphoma with high-dose chemotherapy and autologous peripheral stem-cell support. (6/254)
BACKGROUND: Castleman's disease or angiofollicular lymph node hyperplasia is a rare entity with a localized/unicentric or a generalized/multicentric presentation. While surgery is curable for most localized presentations, there is limited information regarding the optimal management of the multicentric type. The latter type is associated with a poor prognoses and can be associated with the development of lymphoma and infections. PATIENTS AND METHODS: In this report we describe a case of multicentric Castleman's disease who failed steroids and chemotherapy and developed a follicular mixed lymphoma. He was treated with high-dose chemotherapy with autologous stem-cell support and remains disease at four years of follow-up. CONCLUSIONS: A long-term durable remission may be possible with high dose chemotherapy with stem-cell support. This treatment modality should be considered an option in the management of multicentric Castleman's disease. (+info)Development of a calcifying fibrous pseudotumour within a lesion of Castleman disease, hyaline-vascular subtype. (7/254)
A nine year old boy with localised Castleman disease of the hyaline-vascular subtype developed a calcifying fibrous pseudotumour. This pathological association does not appear to have been described before. In this case, the development of this very unusual soft tissue tumour-like process was thought to be related to a previous fine needle aspiration biopsy, which was performed because of lymphadenopathy localised to the right inguinal area. This case provides further evidence of the reactive nature of calcifying fibrous pseudotumour and also broadens the pathological spectrum of the stromal cell proliferation that occasionally supervenes within lesions of Castleman disease, hyaline-vascular type. (+info)Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. (8/254)
Castleman's disease, an atypical lymphoproliferative disorder, can be classified into 2 types: hyaline-vascular and plasma cell types according to the histologic features of the affected lymph nodes. The plasma cell type is frequently associated with systemic manifestations and is often refractory to systemic therapy including corticosteroids and chemotherapy, particularly in multicentric form. Dysregulated overproduction of interleukin-6 (IL-6) from affected lymph nodes is thought to be responsible for the systemic manifestations of this disease. Therefore, interference with IL-6 signal transduction may constitute a new therapeutic strategy for this disease. We used humanized anti-IL-6 receptor antibody (rhPM-1) to treat 7 patients with multicentric plasma cell or mixed type Castleman's disease. All patients had systemic manifestations including secondary amyloidosis in 3. With the approval of our institution's ethics committee and the consent of the patients, they were treated with 50 to 100 mg rhPM-1 either once or twice weekly. Immediately after administration of rhPM-1, fever and fatigue disappeared, and anemia as well as serum levels of C-reactive protein (CRP), fibrinogen, and albumin started to improve. After 3 months of treatment, hypergammaglobulinemia and lymphadenopathy were remarkably alleviated, as were renal function abnormalities in patients with amyloidosis. Treatment was well tolerated with only transient leukopenia. Histopathologic examination revealed reduced follicular hyperplasia and vascularity after rhPM-1 treatment. The pathophysiologic significance of IL-6 in Castleman's disease was thus confirmed, and blockade of the IL-6 signal by rhPM-1 is thought to have potential as a new therapy based on the pathophysiologic mechanism of multicentric Castleman's disease. (Blood. 2000;95:56-61) (+info)Giant lymph node hyperplasia, also known as Castleman disease, is a benign but rare disorder characterized by an abnormal overgrowth of lymphoid tissue within lymph nodes, leading to their enlargement and potential compression of surrounding structures.
Giant lymph node hyperplasia, also known as Castlemans disease, is a rare benign condition characterized by the abnormal enlargement of lymph nodes due to an overgrowth of cells. It can affect people of any age but is more commonly seen in young adults and children.
The enlarged lymph nodes caused by this condition are typically round, firm, and mobile, and they may be found in various locations throughout the body, including the neck, chest, abdomen, and pelvis. In some cases, the enlarged lymph nodes may cause symptoms such as pain, pressure, or difficulty swallowing, depending on their location.
Giant lymph node hyperplasia can be classified into two main types: unicentric and multicentric. Unicentric Castleman's disease affects a single group of lymph nodes, while multicentric Castleman's disease affects multiple groups of lymph nodes throughout the body.
The exact cause of giant lymph node hyperplasia is not fully understood, but it is thought to be related to an overactive immune response. In some cases, it may be associated with viral infections such as HIV or HHV-8. Treatment for this condition typically involves surgical removal of the affected lymph nodes, along with medications to manage any associated symptoms and prevent recurrence.
Lymph nodes are specialized oval-shaped tissues that constitute an essential part of the immune system, functioning as sites for production and activation of immune cells (lymphocytes) and as filters for lymph fluid to remove foreign substances, cellular debris, and cancer cells.
Lymph nodes are small, bean-shaped organs that are part of the immune system. They are found throughout the body, especially in the neck, armpits, groin, and abdomen. Lymph nodes filter lymph fluid, which carries waste and unwanted substances such as bacteria, viruses, and cancer cells. They contain white blood cells called lymphocytes that help fight infections and diseases by attacking and destroying the harmful substances found in the lymph fluid. When an infection or disease is present, lymph nodes may swell due to the increased number of immune cells and fluid accumulation as they work to fight off the invaders.
Hyperplasia is an abnormal multiplication and growth of cells leading to an increase in the size of a tissue or organ, which can be physiological or pathological, responding to various stimuli such as hormones, mitogens, or chronic irritation.
Hyperplasia is a medical term that refers to an abnormal increase in the number of cells in an organ or tissue, leading to an enlargement of the affected area. It's a response to various stimuli such as hormones, chronic irritation, or inflammation. Hyperplasia can be physiological, like the growth of breast tissue during pregnancy, or pathological, like in the case of benign or malignant tumors. The process is generally reversible if the stimulus is removed. It's important to note that hyperplasia itself is not cancerous, but some forms of hyperplasia can increase the risk of developing cancer over time.
Rangelia
Langhans type multinucleate giant cells may be present in the lymph nodes and the choroid plexus. Erythroid hyperplasia may be ...
Castleman disease
Keller AR, Hochholzer L, Castleman B (March 1972). "Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of ... of tissue from enlarged lymph nodes. Variations in the lymph node tissues of patients with CD have led to 4 histological ... involves a single enlarged lymph node or multiple enlarged lymph nodes within a single region of the body that display ... Castleman disease (CD) can involve one or more enlarged lymph nodes in a single region of the body (unicentric CD, UCD) or it ...
Unicentric Castleman disease
... also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of ... have an enlarged lymph node or multiple enlarged lymph nodes in a single lymph node region. It is the most common subtype of ... Keller AR, Hochholzer L, Castleman B (March 1972). "Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of ... Radiologic imaging shows an enlarged lymph node or multiple enlarged lymph nodes in a single region, which are typically 18F- ...
Kinase
June 1996). "The role of human herpesvirus 8 and Epstein-Barr virus in the pathogenesis of giant lymph node hyperplasia ( ...
Idiopathic multicentric Castleman disease
... also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of ... Patients with iMCD may experience enlarged lymph nodes in multiple lymph node regions; systemic symptoms (fever, night sweats, ... and a lymph node biopsy showing features consistent with Castleman disease. A lymph node biopsy alone is not sufficient to make ... enlarged lymph nodes with characteristic findings are present in multiple lymph node regions. The multicentric variants of ...
HHV-8-associated MCD
... also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of rare ... People with HHV-8-associated MCD may experience enlarged lymph nodes in multiple lymph node regions; systemic symptoms, such as ... enlarged lymph nodes with characteristic findings are present in multiple lymph node regions. The multicentric variants of ... diagnosis requires enlargement of lymph nodes in multiple lymph node regions (typically confirmed with radiologic imaging), ...
List of MeSH codes (C20)
... giant lymph node hyperplasia MeSH C20.683.515.501 - immunoblastic lymphadenopathy MeSH C20.683.515.512 - immunoproliferative ...
List of MeSH codes (C15)
... giant lymph node hyperplasia MeSH C15.604.515.292 - granuloma MeSH C15.604.515.292.007 - angiolymphoid hyperplasia with ... lymph node MeSH C15.604.360.500 - lymphangiectasis, intestinal MeSH C15.604.451.500 - lymphangiectasis, intestinal MeSH C15.604 ... angiolymphoid hyperplasia with eosinophilia MeSH C15.378.553.231.335 - eosinophilia-myalgia syndrome MeSH C15.378.553.231.348 ...
Cat-scratch disease
The regional lymph nodes demonstrate follicular hyperplasia with central stellate necrosis with neutrophils, surrounded by ... often accompanied by multinucleated giant cells, lymphocytes, and eosinophils. ... Symptoms typically include a non-painful bump or blister at the site of injury and painful and swollen lymph nodes. People may ... Cat-scratch disease commonly presents as tender, swollen lymph nodes near the site of the inoculating bite or scratch or on the ...
Epstein-Barr virus-associated lymphoproliferative diseases
... this disorder is characterized by hyperplasia of plasma cells, florid hyperplasia of lymph node follicles, and infectious ... Chronic autoimmune or inflammatory diseases (e.g. rheumatoid arthritis, Graves' disease, Giant-cell arteritis, sarcoidosis, or ... slowly progressive swelling of cervical lymph nodes. About 33% of cases exhibit (with or without cervical lymph node swelling) ... lymph nodes have areas of hyperplasia, focal necrosis, and small granulomas; spleen shows atrophy of white pulp with congested ...
Santosh G. Honavar
"Fine needle aspiration cytology in diagnosis of metastatic sebaceous gland carcinoma of the eyelid to the lymph nodes with ... "Isolated giant xanthogranuloma of the orbit". Indian J Ophthalmol. 55 (2): 156-8. doi:10.4103/0301-4738.30718. PMID 17322614.{{ ... "Pseudoepitheliomatous hyperplasia mimicking ocular surface squamous neoplasia following cultivated limbal epithelium ... "Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis". ...
Ovarian cancer
They frequently metastasize to nearby lymph nodes, especially para-aortic and pelvic lymph nodes. The most common symptom of ... Syncytiotrophoblast giant cells also occur in polyembryomas. Primary ovarian squamous cell carcinomas are rare and have a poor ... endometrial hyperplasia; tender, enlarged breasts; postmenopausal bleeding; and secondary amenorrhea. The mass of the tumor can ... Common areas to which the cancer may spread include the lining of the abdomen, lymph nodes, lungs, and liver. The risk of ...
Transitional epithelium
... lymph nodes and other organs, including bone. Common risk factors of transitional cell carcinoma include long-term misuse of ... Papillary urothelial lesions Papillary urothelial hyperplasia Urothelial papilloma Papillary urothelial neoplasm of low ... with syncitiotrophoblastic giant cells Urothelial carcinoma with rhabdoid differentiation Urothelial carcinoma similar to giant ... Transitional cell carcinoma can metastasize, or spread to other parts of the body via the surrounding tissues, the lymph system ...
Index of oncology articles
... lymph gland - lymph node - lymph node dissection - lymph node drainage - lymph node mapping - lymph vessel - lymphadenectomy - ... giant cell fibroblastoma - gimatecan - GIST - Gleason score - Gleevec - Gliadel Wafer - glial cell - glial tumor - glioblastoma ... atypical hyperplasia - ATRT atypical teratoid/rhabdoid tumor - augmerosen - autoimmune disease - autologous - autologous bone ... sentinel lymph node - sentinel lymph node biopsy - sentinel lymph node mapping - seocalcitol - SERM - serotonin - sertraline - ...
Invasive carcinoma of no special type
4 positive lymph nodes, respectively. Another study showed "90% of recurrences occurred within 9, 7, and 5 years for patients ... Atypical ductal hyperplasia Collagenous spherulosis Male breast cancer Lakhani SR (2012). WHO classification of tumours of the ... carcinoma with osteoclast-like stromal giant cells, carcinoma with choriocarcinomatous features, and carcinoma with melanotic ... Regardless of the histological subtype, the prognosis of IDC depends also on tumor size, presence of cancer in the lymph nodes ...
Dog health
Signs include weight loss, fever, cough, enlarged lymph nodes, and lameness. Veterinary parasitology studies both external and ... Panosteitis occurs in large and giant breed dogs usually between the age of five and fourteen months and manifests as fever, ... and benign prostatic hyperplasia. Psychological anxieties affecting dogs include noise phobia and separation anxiety. Some ... Signs include weight loss, cough, fever, enlarged lymph nodes, draining skin lesions, eye inflammation with discharge, ...
Melanoma
If a lymph node is positive, depending on the extent of lymph node spread, a radical lymph node dissection will often be ... Fair- and red-haired people, persons with multiple atypical nevi or dysplastic nevi and persons born with giant congenital ... a medial right temple with adjacent sebaceous hyperplasia, lateral Malignant Melanoma in situ, left anterior shoulder marked ... lymph node biopsies and examination of the lymph nodes are also performed in patients to assess spread to the lymph nodes. A ...
List of skin conditions
... giant condyloma of Buschke-Löwenstein tumor) Hand-foot-and-mouth disease Heck's disease (focal epithelial hyperplasia) ... mucocutaneous lymph node syndrome) Levamisole-induced vasculitis Lichen aureus (lichen purpuricus) Livedo racemosa Livedo ... Giant cell fibroblastoma Giant cell tumor of the tendon sheath (giant cell synovioma, localized nodular tenosynovitis, ... Actinic granuloma (O'Brien granuloma) Annular elastolytic giant cell granuloma (giant cell elastophagocytosis, Meischer's ...
List of dog diseases
In dogs it affects the gastrointestinal system and lymph nodes, and rarely the skin. Mucormycosis is a collection of fungal and ... It is more common in large and giant breed dogs. Histiocytoma is a benign skin tumor that is more frequent in young dogs (. ... Reproductive diseases Prostate disease* in dogs includes benign prostatic hyperplasia (BPH), prostatitis (infection of the ... It is characterized by sinoatrial node dysfunction and may include atrioventricular node disease and bundle branch block. ...
The clinicopathological analysis of pulmonary parenchymal involvement of multicentric giant lymph node hyperplasia (Castleman's...
The clinicopathological analysis of pulmonary parenchymal involvement of multicentric giant lymph node hyperplasia (Castlemans ... It shows similar morphological characteristics to those found in lymph nodes. Immunohistochemistry and gene rearrangement test ... In the thorax, Castlemans disease usually manifests as hilar and mediastinal lymph node enlargement. Pulmonary parenchymal ...
Rangelia - Wikipedia
Orphanet: Search a disease
Cat Scratch Disease (Cat Scratch Fever): Background, Pathophysiology, Etiology
... is a bacterial infection affecting lymph nodes that drain the sites of inoculation. Bartonella henselae, a gram-negative rod, ... Lymph nodes. In general, lymph nodes become enlarged in the 1-2 weeks after exposure. They are often tender and occasionally ... Histiocytes and multinucleated giant cells are often present. Finally, stellate microabscesses form, and nodes can become ... Lymphoid hyperplasia with arteriolar proliferation and reticular cell hyperplasia is seen early in the disease. As the disease ...
POEMS syndrome | DermNet
Castleman disease (giant cell or angiofollicular lymph node hyperplasia). *Increased vascular endothelial growth factor (VEGF) ... Lymph node biopsy of enlarged nodes. *Skin biopsy results are usually nonspecific *Scleroderma-like lesions show nonspecific ... Biopsy of an enlarged lymph node may show Castleman disease. *Lumbar puncture in those with neuropathy may show increased ...
Biologics
NIOSHTIC-2 Search Results - Full View
Pulmonary inflammation, epithelial hyperplasia, and lymph node translocation after multi-walled carbon nanotube inhalation. ... Peribronchiolar inflammation was principally histiocytic and neutrophilic with occasional giant cells. In many macrophages, ... Histopathologic sections of lung and tracheobronchial lymph nodes were examined at all time points and sections of nose (4 ... MWCNT translocation to the tracheobronchial lymph node progressed with time and localized to the deep paracortex, the normal ...
HuGE Navigator|Genopedia|PHGKB
DeCS 2018 - Changed terms
DeCS 2018 - Changed terms
DeCS 2018 - Changed terms
DeCS 2018 - Changed terms
Hyperplasia. Medical search
The condition is also known as "Benign Giant Lymph Node Hyperplasia" or "Malignant Giant Lymph Node Hyperplasia," depending on ... Giant Lymph Node Hyperplasia. Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized ... The definition of "Giant Lymph Node Hyperplasia" is a rare condition characterized by an abnormal growth of lymph nodes, which ... HyperplasiaProstatic HyperplasiaEndometrial HyperplasiaAdrenal Hyperplasia, CongenitalGingival HyperplasiaThymus Hyperplasia ...
Angioimmunoblastic Lymphoma: Overview, Pathophysiology, Etiology
Multicentric giant lymph node hyperplasia. * Acute viral lymphadenitis. * Hypersensitivity syndrome (eg, dapsone) [31] ... lymph node, and skin are key in diagnosing AILD. AILD is diagnosed by a positive biopsy result obtained from an affected lymph ... Biopsies of the bone marrow, lymph node, and skin are key in diagnosing AILD (see Workup). Many agents have been used to treat ... Stage II - Involvement of 2 or more lymph node regions on the same side of the diaphragm (II) or localized involvement of an ...
Aims and Scope
Alternative Treatment for SacroIliac Joint Dysfunction with Ayurveda
Female Health Archives | Page 3 of 55 | Dr. Vikram Chauhan's Blog
Persistent Night Sweats: Diagnostic Evaluation | AAFP
Lymph node biopsy. Generalized sweating, headache, labile hypertension, paroxysms of palpitations. Pheochromocytoma. 24-hour ... Other autoimmune conditions associated with night sweats include sarcoidosis and giant cell arteritis. ... Palpable nodes that are associated with systemic symptoms such as night sweats or that have been present longer than four to ... Osler nodes, splinter hemorrhages, travel, weight loss. Endocarditis. HIV. Tuberculosis. Complete blood count, purified protein ...
International Journal of Head and Neck Surgery
asia - Search Results | Abbreviation Finder
Understanding the different types of Castleman disease - Healthhandbook.online
Alternatively known as giant lymph node hyperplasia and angiofollicular lymph node hyperplasia, Castleman disease is not cancer ... The chest or abdomen lymph nodes are affected and the condition prompts unnatural growth of the lymph nodes. The enlarged ... a subtype of the lymph node condition as the lymph tissue is found in many places throughout the body including the lymph nodes ... The lymph nodes in the neck, groin, and underarm area are also affected by visible indicators including the growth of lumps ...
Case of the Week
Castleman disease otherwise known as angiofollicular or benign giant lymph node hyperplasia is an uncommon benign ... 7.Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H. Multicentric angiofollicular lymph node hyperplasia: a ... HPR - lymph node showing partially effaced architecture with preserved marginal sinuses. Scattered follicles showing onion ... No other significantly enlarged lymph nodes were detected. Based on the imaging features, differential diagnostic possibilities ...
Kochi City Chapter - IRIA
Castleman disease otherwise known as angiofollicular or benign giant lymph node hyperplasia is an uncommon benign ... 7.Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H. Multicentric angiofollicular lymph node hyperplasia: a ... HPR - lymph node showing partially effaced architecture with preserved marginal sinuses. Scattered follicles showing onion ... No other significantly enlarged lymph nodes were detected. Based on the imaging features, differential diagnostic possibilities ...
EurekaMag PDF full texts Chapter 5873
Mediastinal giant lymph node hyperplasia accompanied by hypergammaglobulinemia. Nihon Kyobu Shikkan Gakkai Zasshi 18(11): 823- ... Quint, L.E.; Glazer, G.M.; Orringer, M.B.; Francis, I.R.; Bookstein, F.L. 1986: Mediastinal lymph node detection and sizing at ... Tan, Y.L. 1984: Mediastinoscopy for the diagnosis of tuberculosis of mediastinal lymph nodes. Zhonghua Jie He He Hu Xi Xi Ji ... Libshitz, H.I.; McKenna, R.J. 1984: Mediastinal lymph node size in lung cancer. Ajr. American Journal of Roentgenology 143(4): ...
Castleman Disease in the Buccal Space Mimicking Lymphoma: A Case Report | Hashemi | Advances in Bioscience and Clinical Medicine
Castleman Disease | medtigo
... also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, is a rare disorder that affects the lymph ... also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, is a rare disorder that affects the lymph ... also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, is a rare disorder that affects the lymph ... Unicentric Castleman disease (UCD) is usually localized to a single lymph node or a group of lymph nodes in one region of the ...
AICDAbase: Non-X-linked hyper-IgM syndrome | Main page
Registration Dossier - ECHA
A lymphoid hyperplasia was observed in the lung-associated lymph nodes starting at 0.3 mg/m3 at the end of the exposure period ... Furthermore, there was an accumulation of macrophages/giant cells/granuloma in the lung associated lymph nodes starting at 1.5 ... A lymphoid hyperplasia was observed in the lung-associated lymph nodes starting at 0.3 mg/m3 at the end of the exposure period ... Lung-associated lymph nodes (LALN) showed lymphoid hyperplasia starting in females at 0,3 mg/m3, in males at 1.5 mg/m3 ( ...
International Classification of Diseases - Diseases of the Circulatory System
... ascites cyst Lymph node or vessel: fistula infarction rupture Excludes: chylocele: filarial (125.0-125.9) tunica vaginalis ( ... 447.3 Hyperplasia of renal artery Fibromuscular hyperplasia of renal artery 447.4 Celiac artery compression syndrome Celiac ... Fiedlers giant cell isolated (diffuse) (granulomatous) nonspecific granulomatous 422.92 Septic myocarditis Myocarditis, acute ... 446.1 Acute febrile mucocutaneous lymph node syndrome [MCLS] Kawasaki disease 446.2 Hypersensitivity angiitis Excludes: ...
SpleenCastlemanAxillaryBenign prostatic hLymphoidSurrounding tissuesHistopathologyCastleman'sMesentericHypertrophyMalignantLymphaticHistiocyticTumorSuperficialInflammationReactiveExcisionFocalCarcinomasNecrosisCellsDiagnosisBonePatientsJunctionLungPresentChestInfectionsCommonVirusesRegionalPrimaryNormalClinicalFoundBodyMadeStudyRare
Spleen4
- The liver, the lymph nodes, and the spleen are the organs most frequently involved. (medscape.com)
- Enlargement of the lymph nodes and spleen is secondary to changes consistent with Castleman disease (giant angiofollicular hyperplasia, multicentric plasma cell variant) in most patients. (medscape.com)
- We detected no acid-fast bacilli in the mesenteric lymph nodes, the spleen, or the liver. (cdc.gov)
- 1990. Spleen, lymph nodes, and thymus. (nih.gov)
Castleman5
- One of disorders related to lymph nodes is Castleman tumor. (planetayurveda.net)
- Castleman tumor is a rare condition that involves the excess and rapid growth of cells in lymph nodes and related tissues. (planetayurveda.net)
- Castleman tumor was firstly described by Dr.Benjamin Castleman in 1950, when he detected uncommon lymph-node disorder in one of his patients. (planetayurveda.net)
- Multicentric castleman disease is the type of disease affecting numerous areas of lymph nodes or lymph nodes throughout the body. (planetayurveda.net)
- Lymph nodes of the neck, underarm, groin areas and collarbone become enlarged in a multicentric castleman tumor. (planetayurveda.net)
Axillary2
- The medical anamnesis revealed that the patient was operated (modified radical mastectomy with axillary lymph node dissection) 16 years ago for breast carcinoma of the right breast. (hasekidergisi.com)
- We report a case of total excision of a rare giant axillary mass classified as ectopic breast tissue in a male patient and suggest the need to reconsider the possibility of various diseases rarely reported in men and the need for further research. (jbd.or.kr)
Benign prostatic h2
- Prostate embolization in the treatment of benign prostatic hyperplasia: what s the point? (rb.org.br)
- By far and away the most common cause is a hormonally fed enlargement of the prostate called benign prostatic hyperplasia or BPH (more of this later). (pawdiet.com)
Lymphoid1
- Tentative characterization of new described ( 1-6 ), but most reports have showed hemorrhages, lymphoid environmental giant viruses by MALDI- discussed experimental infections or hyperplasia, and small foci of TOF mass-spectrometry. (cdc.gov)
Surrounding tissues1
- The peripheral lymphatic system originates from the primary lymph sacs, then spreads by endothelial sprouting into the surrounding tissues and organs, where local capillaries are formed. (slideshare.net)
Histopathology1
- 2006. Enhanced histopathology of the lymph nodes. (nih.gov)
Castleman's2
Mesenteric3
- and enlarged mesenteric lymph nodes. (cdc.gov)
- Histologically, the nodular lesions in the ileum showed severe granulomatous enteritis with large areas of necrosis and numerous multinucleated giant cells (Figure, panel A). Ziehl-Neelsen stain demonstrated large numbers of acid-fast bacilli in macrophages and multinucleated giant cells in the intestine ( Figure , panel B). The mesenteric lymph node also exhibited a granulomatous inflammation with multinucleated giant cells. (cdc.gov)
- Pigment is a common finding in lymph nodes of control and treated rodents, particularly in the mesenteric and mandibular lymph nodes. (nih.gov)
Hypertrophy3
- In lung, the principal changes were 1) inflammation centered around the bronchioloalveolar junction, 2) vasculitis, and 3) bronchiolar epithelial hypertrophy and hyperplasia. (cdc.gov)
- Bronchiolar hypertrophy and hyperplasia were present after 4 days and persisted. (cdc.gov)
- Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (lookformedical.com)
Malignant2
- The majority were nonspecific reactive hyperplasia with a polymorphic, high cell density pattern and without malignant features, followed by pyogenic tuberculous lymphadenitis. (who.int)
- Giant cell carcinomas are composed mostly of malignant giant cells, without differentiated carcinomatous elements 4 . (radiopaedia.org)
Lymphatic2
- Though MCD is classified as a non-cancerous disorder, it causes an overproduction of benign lymphatic cells in the lymph nodes and lymphatic tissues, which puts patients at high risk of developing certain forms of cancer. (keefelaw.com)
- Lymphatic drainage of the ovaries is through the pelvic and para-aortic lymph nodes. (esehospitaldebaranoa.gov.co)
Histiocytic1
- Peribronchiolar inflammation was principally histiocytic and neutrophilic with occasional giant cells. (cdc.gov)
Tumor1
- Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. (endocrine-abstracts.org)
Superficial1
- Fine needle aspirates (FNA) of superficial lymph nodes were obtained from 150 patients complaining of lymphadenopathy. (who.int)
Inflammation1
- Pulmonary inflammation, epithelial hyperplasia, and lymph node translocation after multi-walled carbon nanotube inhalation. (cdc.gov)
Reactive3
- Benign lesions were found in more than half of the patients (55.3%), the majority of which were nonspecific reactive hyperplasia followed by tuberculous lymphadenitis. (who.int)
- Aspirates of the remaining 13 revealed nothing more than pyogenic infection [4], nonspecific reactive hyperplasia [5], or else they were inconclusive. (who.int)
- indicate that a factor secreted by fibroblast/osteoblast (receptor activator of nuclear factor ligand (RANKL)) binds to stromal-monocyte derived cells to induce giant cell formation that might be reactive [ 8 ]. (hindawi.com)
Excision1
- Surgical excision of the same lymph node was carried out immediately after aspiration, and finally the results of cytological and histological diagnosis were tabulated and compared. (who.int)
Focal1
- Additionally, the rabbit had mild suppurative splenitis, mild lymphohistiocytic to granulomatous hepatitis, mild focal lymphocytic interstitial orchitis, and a hyperplasia of the myeloic cell line in the femoral and sternal bone marrow. (cdc.gov)
Carcinomas2
- Giant cell carcinomas of the lung are a rare type of non-small cell lung carcinomas ( NSCLC ) classified under sarcomatoid carcinomas of the lungs . (radiopaedia.org)
- Giant cell carcinomas often present with peripheral neutrophilia and fever related to the production of granulocyte colony-stimulating factor (G-CSF) 3 . (radiopaedia.org)
Necrosis1
- Cytologically, changes suggestive of tuberculous lymphadenitis were in the form of granulomatous reactions, and included eosinophilic caseous necrosis, epithelioid and multinucleated giant cells. (who.int)
Cells7
- Langhans type multinucleate giant cells may be present in the lymph nodes and the choroid plexus. (wikipedia.org)
- MWCNT translocation to the tracheobronchial lymph node progressed with time and localized to the deep paracortex, the normal location of T lymphocytes and dendritic cells. (cdc.gov)
- Additionally, the disease seems to target individuals who are already ill, as it is often diagnosed in patients who also have the human herpes virus 8 (HHV8) infection, HIV, or who develop Kaposi sarcoma, which is a type of cancer that develops from cells lining the lymph nodes and blood vessels. (keefelaw.com)
- Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15-30 nuclei. (hindawi.com)
- According to WHO, it is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells, and occasional trabeculae of woven bone [ 2 ]. (hindawi.com)
- Sabin's Model : The isolated primitive lymph sacs originate from endothelial cells that bud from the veins during early development. (slideshare.net)
- Histiocytosis, histiocytosis, or histiocytosis syndrome is a group of diseases caused by abnormal proliferation of histocytes, such as giant cells, in various parts of the body. (drleepediatrics.com)
Diagnosis2
- Cytological findings were analysed in correlation with the corresponding histopathological diagnosis of the same excised nodes. (who.int)
- Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. (hindawi.com)
Bone2
- Erythroid hyperplasia may be present in the bone marrow. (wikipedia.org)
- Central giant cell granuloma (CGCG) is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. (hindawi.com)
Patients3
- Patients who present with a central giant cell lesion in the maxilla or mandible should be screened for hyperparathyroidism (HPT) to differentiate the lesion as a brown tumour. (hindawi.com)
- Patterns B and C patients also mostly presented at stage I with negative lymph nodes but had greater frequency of recurrence. (stanford.edu)
- Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database. (radiopaedia.org)
Junction2
- The two jugular lymph sacs were proposed to develop in the junction of the sub-clavian and anterior cardinal veins by endothelial budding from the anterior cardinal veins. (slideshare.net)
- The remaining lymph sacs originate from the mesonephric vein and those in the dorsomedial edge of the Wolffian bodies in the junction of the subclavian and anterior cardinal veins. (slideshare.net)
Lung1
- Histopathologic sections of lung and tracheobronchial lymph nodes were examined at all time points and sections of nose (4 levels) were examined after the 12 day exposure. (cdc.gov)
Present3
- Electron microscopic studies reveal giant mitochondria, a finding not present in any other type of pituitary gland adenomas. (nih.gov)
- Lymph glands are present in small groups in various parts of the body. (planetayurveda.net)
- A giant mass measuring more than 10 cm in diameter was present in the patient's right axilla. (jbd.or.kr)
Chest1
- In this type, only one group of lymph nodes are getting infected and most affected areas are of chest and belly. (planetayurveda.net)
Infections2
- Most of the reports were of all examined animals, as well as large experimental or isolated spontaneous lymph nodes of the cervical region, infections in pets ( 1 , 2 ), zoo ( 3 ), mainly retropharyngeal. (cdc.gov)
- Lymph nodes are tiny, bean-shaped glands which defend the body against infections and by filtering germs from the body. (planetayurveda.net)
Common1
- Moreover, lymph nodes are a common site of metastasis for different cancers. (who.int)
Viruses1
- Lymph nodes act as filters to trap bacteria, viruses and other harmful pathogens in it. (planetayurveda.net)
Regional3
- When specifically related to treatment, exogenous pigment is generally most prominent in lymph nodes regional to the route of test article administration. (nih.gov)
- On palpation, there were no visible subcutaneous nodules in areas adjacent to ulcers and regional lymph nodes seemed normal. (scialert.net)
- Regional lymph nodes were not palpable. (hasekidergisi.com)
Primary2
- Primary HPT results from autonomous hyperplasia or tumour, usually an adenoma. (hindawi.com)
- They suggested that the primary lymph sacs arise in the mesenchyme, independent of the veins, and secondarily establish venous connections. (slideshare.net)
Normal1
- But sometimes, lymph nodes have to suffer from unwell conditions which interfere with their normal functioning. (planetayurveda.net)
Clinical1
- In this case report, we describe a rare clinical case of a giant unilateral mass of ectopic breast tissue occurring in the axilla of a male patient. (jbd.or.kr)
Found1
- Melanin is another endogenous pigment that can be found within lymph nodes. (nih.gov)
Body2
- Our body consists of lymph nodes which plays a vital role in supporting the body to fight with infection causing microbes. (planetayurveda.net)
- So, we can understand the importance of lymph nodes in our body. (planetayurveda.net)
Made1
- Pictures of lymph nodes are made by strong magnet and radio waves. (planetayurveda.net)
Study1
- Lymph node, Medullary sinuses - Pigment in a male Harlan Sprague-Dawley rat from a chronic study. (nih.gov)
Rare1
- MCD-also known as giant lymph node hyperplasia and angiofollicular lymph node hyperplasia-is a rare condition that severely weakens the immune system. (keefelaw.com)
