Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Synteny: The presence of two or more genetic loci on the same chromosome. Extensions of this original definition refer to the similarity in content and organization between chromosomes, of different species for example.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Databases, Nucleic Acid: Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.Genome, Fungal: The complete gene complement contained in a set of chromosomes in a fungus.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Individualized Medicine: Therapeutic approach tailoring therapy for genetically defined subgroups of patients.Metagenomics: The genomic analysis of assemblages of organisms.Genetic Variation: Genotypic differences observed among individuals in a population.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.High-Throughput Nucleotide Sequencing: Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.Genetic Research: Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Genetics, Medical: A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Contig Mapping: Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Genes, Plant: The functional hereditary units of PLANTS.Genome, Insect: The genetic complement of an insect (INSECTS) as represented in its DNA.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Genetics: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Proteome: The protein complement of an organism coded for by its genome.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Genome, Archaeal: The genetic complement of an archaeal organism (ARCHAEA) as represented in its DNA.Gene Order: The sequential location of genes on a chromosome.Genome, Helminth: The genetic complement of a helminth (HELMINTHS) as represented in its DNA.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Comparative Genomic Hybridization: A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Gene Duplication: Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.Genome, Protozoan: The complete genetic complement contained in a set of CHROMOSOMES in a protozoan.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Microbiology: The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Gene Transfer, Horizontal: The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.Crops, Agricultural: Cultivated plants or agricultural produce such as grain, vegetables, or fruit. (From American Heritage Dictionary, 1982)DNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Physical Chromosome Mapping: Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Nutrigenomics: The study of the relationship between NUTRITIONAL PHYSIOLOGY and genetic makeup. It includes the effect of different food components on GENE EXPRESSION and how variations in GENES effect responses to food components.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Bacterial Proteins: Proteins found in any species of bacterium.National Human Genome Research Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.Genetic Testing: Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.Genetic Techniques: Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.Structural Homology, Protein: The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.Sorghum: A plant genus of the family POACEAE. The grain is used for FOOD and for ANIMAL FEED. This should not be confused with KAFFIR LIME or with KEFIR milk product.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Adaptation, Biological: Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Toxicogenetics: The study of existing genetic knowledge, and the generation of new genetic data, to understand and thus avoid DRUG TOXICITY and adverse effects from toxic substances from the environment.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

*  Home|Genomics|CDC

The mission of the Public Health Genomics is to integrate advances in human genetics into public health research, policy, and ... Genomics and Diseases. Genomics is important for many diseases of public health significance ... Genomics & Health Impact Blog. A blog devoted to genomic issues in research, policy and practice ... Pathogen Genomics New tools are changing the landscape in the fight against infectious diseases ...
https://cdc.gov/genomics/default.htm

*  HuGENet|Genomics|CDC

Public Health Genomics Knowledge Base. CDC curated database that features epidemiologic studies of human and pathogen genomics. ... Check out all CDC publications in epidemiology and public health genomics.. Epidemiology Resources. * HuGE Navigator. A ... The Office of Public Health Genomics tracks epidemiologic study results in our weekly horizon scan and Advanced Molecular ... Transforming epidemiology for 21st century population health in the age of genomics and big data, CEBP (2013) ...
https://cdc.gov/genomics/hugenet/

*  Genomics

Axygen genomics products are right at home in virtually every area of genomics research-in the U.S. and around the world. ... Genomics. From collection to purification, our comprehensive portfolio of Axygen® products can simplify your workflow across ... No matter how diverse your requirements, stay focused on the complex science of genomics, while we take care of those little ... Unsure about a specific product or preference for your genomics application? Try Axygen first, at no risk. Request a free ...
https://corning.com/asean/en/products/life-sciences/products/genomics.html

*  Sackler Institute for Comparative Genomics

Science and Genomics at the American Museum of Natural History. Throughout its history, the Museum has made many contributions ... To effectively organize and build upon these remarkable gains in genomics research, the Museum established, in spring 2001, the ... position the Museum to enhance its important contributions to genomics research. ... Sackler Institute for Comparative Genomics (SICG). The Museum and the Institute's approach considers the 3.8 billion year ...
https://amnh.org/our-research/sackler-institute-for-comparative-genomics?action=browse&phylum_id=1

*  Genomics Data | 2213-5960 | Elsevier

Genomics Data is now merging with Data in BriefTo offer improved discoverability and accessibility to our authors' research, ...
https://elsevier.com/journals/genomics-data/2213-5960/open-access-journal

*  BRIEF-Genomics BioSci&Tech receives patent | Reuters

Sept 12 (Reuters) - Genomics BioSci&Tech Co Ltd : * Says it received patent for molecular marker method for screening variation ...
https://in.reuters.com/article/brief-genomics-bioscitech-receives-paten/brief-genomics-bioscitech-receives-patent-idINL4N1LT1JW

*  Paradise Genomics, Inc.: CEO and Executives - Bloomberg

Get to know Paradise Genomics, Inc. CEO & other corporate executives. Learn about the Board of Directors, Executive Committees ... Paradise Genomics, Inc. Board Members*. Name. Board Relationships. Primary Company. Age. Joseph P. Nolan MBA. 2 Relationships. ... Key Executives for Paradise Genomics, Inc.. Name. Board Relationships. Title. Age. Michael T. Falduto Ph.D.. No Relationships. ... To contact Paradise Genomics, Inc., please visit . Company data is provided by S&P Global Market Intelligence. Please use this ...
bloomberg.com/research/stocks/private/people.asp?privcapid=253756407

*  Rubicon Genomics, Inc.: Private Company Information - Bloomberg

Rubicon Genomics, Inc. company research & investing information. Find executives and the latest company news. ... To contact Rubicon Genomics, Inc., please visit . Company data is provided by S&P Global Market Intelligence. Please use this ...
bloomberg.com/research/stocks/private/relationship.asp?personId=247553&privcapId=620917&previousCapId=37559039&previousTitle=Electro-Motion, Inc

*  Biologists Struggle to Make Sense of Genomics

And this summer, Complete Genomics, a biotech firm in Mountain View, California, plans to announce that it will sequence an ... Biologists Struggle to Make Sense of Genomics. By Newsweek Staff On 6/26/09 at 8:00 PM ... And this summer, Complete Genomics, a biotech firm in Mountain View, California, plans to announce that it will sequence an ...
newsweek.com/biologists-struggle-make-sense-genomics-80813

*  Lobbying Spending Database-Synthetic Genomics, 2009 | OpenSecrets

Synthetic Genomics Podesta Group. FIRST QUARTER REPORT. $80,000. Synthetic Genomics Podesta Group. SECOND QUARTER REPORT. $ ... Synthetic Genomics Podesta Group. THIRD QUARTER REPORT. $80,000. Synthetic Genomics Podesta Group. FOURTH QUARTER REPORT. $ ...
opensecrets.org/lobby/client_reports.php?id=D000057360&year=2009

*  CSHL study finds short- and long-term memories require same gene but in differen... ( Cold Spring Harbor N.Y. Why is it t...)

...Cold Spring Harbor N.Y. Why is it that you can instantly recall your...Assistant Professor Josh Dubnau Ph.D. of Cold Spring Harbor Laborato...The CSHL team has found that when fruit flies learn a task each of tw... A tale of two lobes ...,CSHL,study,finds,short-,and,long-term,memories,require,same,gene,but,in,different,circuits,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
bio-medicine.org/biology-news-1/CSHL-study-finds-short--and-long-term-memories-require-same-gene-but-in-different-circuits-9605-1/

*  New book gives a human face to children with congenital hea... ( COLD SPRING HARBOR N.Y. Despite t...)

... COLD SPRING HARBOR N.Y. Despite the fact that congenital hear...The author of the book Max Gerber is a CHD patient himself. I remem...Ten chapters each spotlight a single child. The photographs show the ...With structural and developmental abnormalities that include heart val...,New,book,gives,a,human,face,to,children,with,congenital,heart,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
bio-medicine.org/biology-news-1/New-book-gives-a-human-face-to-children-with-congenital-heart-disease-2286-1/

*  Structure of Human Protein Critical for Silencing Genes Solved Cold Spring Harbor Laboratory Study

In a study published in the journal Cell on May 24, Cold Spring Harbor Laboratory scientists describe the three-dimensional atomic structure of a human
biospace.com/News/structure-of-human-protein-critical-for-silencing/261721

*  Home - Clinical Genomics

The Clinical Genomics Centre provides a broad range of services from upstream study design and grant writing support through to downstream data analysis. We are a state-of-the-art, full service genomics technology facility that operates under cGLP guidelines to meet the rigorous standards necessary for DNA/RNA analysis and generating quality data.. Sample handling and processing are fully automated where applicable, and are performed by advanced robotics which allow for high throughput and improved precision.. The facility is equipped with a comprehensive technology portfolio and exceptional diversity in each technology platform, thereby enabling optimal capacity, economy, efficiency, flexibility, and agility.. ...
clinicalgenomics.ca

*  ARTICLES | Physiological Genomics

Thank you for your interest in spreading the word on Physiological Genomics.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
physiolgenomics.physiology.org/content/early/2017/08/16/physiolgenomics.00078.2017.article-info

*  ARTICLES | Physiological Genomics

Thank you for your interest in spreading the word on Physiological Genomics.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
physiolgenomics.physiology.org/content/early/2017/08/31/physiolgenomics.00034.2017.article-info

*  Landmarks in the History of Genetics

Related links and literature Blanchard, Susan M. (1998). Friedrich Miescher, 1868. The early history of cell biology. Full text (external). Cairns, John, Gunther Stent, and James Watson (eds.) (1992/1966). Phage and the Origins of Molecular Biology." New York: Cold Spring Harbor Press. A Dictionary of Scientists (1999). New York, NY: Oxford University Press. Miescher entry (external). Hewlett, Martin (1998). From Mendel to Biotechnology: A Critical Look at the Historical Development and Philosophical Foundations of Modern Biology. Full text (external). Judson, Horace F. (1996). The Eighth Day of Creation. Cold Spring Harbor Press, New York. An excellent source on the early history of biology. Lane, Jo Ann (1994). History of Genetics Timeline. Schrödinger, Erwin (1944). What is Life. Cambridge, UK: Cambridge University Press. Stent, Gunther S. (1978). Paradoxes of Progress. San Francisco: Freeman. 95-109. Tijan, Rober and Michael C. Holmes (2000). Science 5 May 2000. Press release ...
cogweb.ucla.edu/ep/DNA_history.html

*  Division of Functional Genomics & Systems Medicine

Although human genome sequence has completed in April 2003, the whole gene annotation and functional annotation of each gene is yet to be done. In our laboratory we are focusing more on the functional genomics based on the genome-wide approach combined with genetic approach. We are also targeting on a research of gene network and pathological network of diseased conditions by analyzing the genome-wide data derived from many model organisms using bioinformatics. By using a comparative genomics approach, we will try to understand the pathophysiological condition and to find a cure for common diseases. We are hoping to bridge the gap between basic science and clinical medicine.. ...
saitama-med.ac.jp/genome/eng/Div05_FGSM/index.html

*  Data Integration for Cancer Genomics

... Personalized Medicine Tumor Board Question: given all we know about a patient, what is the "optimal" treatment? The Cancer Genome Atlas Project (TCGA) SNP Structural variations DNA methylation Gene expression microRNA expression Paired samples/unpaired samples Data Processing Challenges Contamination Subclones Biological questions • Changes in genes between cancer and normals • Disease heterogeneity, subtypes • Joint modeling, mechanisms Integrative approach Meta-analytical approach PARADIGM: PAthway Recognition Algorithm using Data Integration on Genomic Models Xpxn = Wpx(k-1) Z(k-1)xn + epxn cov(e) = diag(ψ1, ψ2,…, ψp) Non-negative matrix factorization XMxN = WMxK x HKxN All matrix entries are nonnegative Minimize X1: an M x N1 matrix X2: an M x N2 matrix X3: an M x N3 matrix X1 = W x H1 X2 = W x H2 X3 = W x H3 TCGA and GWAS, and ENCODE Cancer Treatment Examples http://discover.nci.nih.gov/cellminer/ Gene expression data: HG-U133A chip, mapped to ...
slidegur.com/doc/62153/data-integration-for-cancer-genomics

*  In Silico RAPD Priming Sites in Expressed Sequences and iSCAR Markers for Oil Palm

International Journal of Genomics is a peer-reviewed, Open Access journal that publishes research articles as well as review articles in all areas of genome-scale analysis. Topics covered by the journal include, but are not limited to: bioinformatics, clinical genomics, disease genomics, epigenomics, evolutionary genomics, functional genomics, genome engineering, and synthetic genomics.
https://hindawi.com/journals/ijg/2012/913709/

*  New Tests Available - Genomics and other omics tools for enabling Medical Decisions (GOMED)

The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
gomed.igib.in/new-tests-available

*  Genetic testing for Tuberous Sclerosis - Genomics and other omics tools for enabling Medical Decisions (GOMED)

The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
gomed.igib.in/new-tests-available/genetictestingfortuberoussclerosis

*  Pharmacogenetic testing for 5-Fluorouracil - Genomics and other omics tools for enabling Medical Decisions (GOMED)

The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
gomed.igib.in/new-tests-available/pharmacogenomics-of-5-fluorouracil

*  Pharmacogenetic testing of 5-Fluorouracil - Genomics and other omics tools for enabling Medical Decisions (GOMED)

The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
gomed.igib.in/new-tests-available/untitledpost

*  BibMe: Generate Functional & Integrative Genomics miscellaneous citations for your bibliography

The month, day, and year a content piece was published electronically (as opposed to in print). Depending on the webpage, it may or may not be shown ...
bibme.org/functional-and-integrative-genomics/miscellaneous-citation/new

*  Genome sequencing is for ecologists, too ( An organism widely used for genetics-ve...)

An organism widely used for genetics-versus-environment studies has jo...At the Daphnia Genomics Consortium's annual meeting in Bloomington thi... Daphnia is important to the environmental sciences where the goal is...Colbourne is a founding member of the Daphnia Genomics Consortium and ...The U.S. Department of Energy and the National Science Foundation fund...,Genome,sequencing,is,for,ecologists,,too,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
bio-medicine.org/biology-news/Genome-sequencing-is-for-ecologists--too-2405-1/

*  Wiley: Principles of Gene Manipulation and Genomics, 7th Edition - Sandy B. Primrose, Richard Twyman

Preface. 1. Gene Manipulation in the Post-Genomics Era.. Part I: Fundamental Techniques of Gene Manipulation:.. 2. Basic Techniques.. 3. Cutting and Joining DNA Molecules.. 4. Basic Biology of Plasmid and Phage Vectors.. 5. Cosmids, Phasmids and Other Advanced Vectors.. 6. Gene Cloning Strategies.. 7. Sequencing Genes and Short Stretches of DNA.. 8. Changing Genes: Site-directed Mutagenesis and Protein Engineering.. 9. Bioinformatics.. Part II: Manipulating DNA in Microbes, Plants and Animals:.. 10. Cloning in Bacteria Other Than Escherichia coli.. 11. Cloning in Saccharomyces cerevisiaea and Other Fungi.. 12. Gene Transfer to Animal Cells.. 13. Genetic Manipulation of Animals.. 14. Gene Transfer to Plants.. 15. Advanced Transgenic Technology.. Part III: Genome Analysis, Genomics and Beyond:.. 16. The Organization and Structure of Genomes.. 17. Mapping and Sequencing Genomes.. 18. Comparative Genomics.. 19. Large-Scale Mutagenesis and Interference.. 20. ...
wiley.com/WileyCDA/WileyTitle/productCd-EHEP002330.html

*  Physiological Genomics

Christopher A. Drummond, Laura E. Crotty Alexander, Steven T. Haller, Xiaoming Fan, Jeffrey X. Xie, David J. Kennedy, Jiang Liu, Yanling Yan, Dawn-Alita Hernandez, Denzil P. Mathew, Christopher J. Cooper, Joseph I. Shapiro, Jiang ...
physiolgenomics.physiology.org

*  Illumina to open app store for genomics, releas...

Illumina to open app store for genomics, releases iPad appFierceBiotech ITIllumina ($ILMN) has ripped a page from Apple's playbook and begun development of an app store for genomics software. | Plant Genomics
scoop.it/t/plant-genomics/p/1677859318/2012/04/29/illumina-to-open-app-store-for-genomics-releases-ipad-app-fiercebiotech-it

*  User:Bmoore - GMOD

Broadly speaking I am a molecular biologist who has converted to bioinformatics. The first 10 years of my career I was doing molecular biology and biochemistry bench work on problems associated with translational recoding. Since 2003 I have mutated into a bioinformatics geek. My work is currently focused broadly in the field of genomics with projects in comparative genomics, genome annotation, biomedical ontologies, personal genomics and human genetic variation, and high throughput imaging. I am enthralled by the opportunities that are being opened by the low cost/high throughput sequencing and imaging technologies available today and thoroughly enjoy working on problems that span the gap between wrangling the technologies needed to manage large genomic datasets and pondering the biology that makes it all interesting and relevant. ...
gmod.org/wiki/User:Bmoore

*  CSHL Cocktails, Chromosomes....and CONFIDENCE

Cold Spring Harbor Laboratory - Founded in 1890, CSHL is a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and a broad educational mission.
cshl.edu/events-calendar/cocktails-chromosomes/418/

*  CSHL Jan Witkowski | Banbury Center

Cold Spring Harbor Laboratory - Founded in 1890, CSHL is a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and a broad educational mission.
https://cshl.edu/Banbury/Witkowski.html

*  CSHL Glenn Turner

Cold Spring Harbor Laboratory - Founded in 1890, CSHL is a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and a broad educational mission.
cshl.edu/Faculty/Glenn-Turner.html

*  Career & Professional Development - Helping Gonzaga University Students and Alumni Clarify and Achieve Their Academic and...

According to Alec Ross, the next trillion dollar industry will be created out of our very own genetic makeup. This industry is referred to as genomics. By definition, genomics is the study of genes and their function in recumbent DNA.. As described by Ross, genomic research has been present since Gregory Mendel, a Czech monk, located the foundations of heredity in the mid-19th century. In 1995, Haemophilus influenza, an infection causing bacteria, was sequenced for the very first time. Shortly after, in 2000, the first "draft" of a human genome was created. This draft cost a staggering $2.7 billion. However, Eric Lander, a human genomics researcher currently believes that the expensive price will drastically drop, allowing commercialization.. Understanding genetic makeups, is and will continue to significantly impact humanity.. In 2013, the genomics market was estimated to be just over $11 billion and is continuing to grow rapidly. According ...
blogs.gonzaga.edu/careercenter/

Ontario Genomics Institute: The Ontario Genomics Institute (OGI) is a not-for-profit organization that manages cutting-edge genomics research projects and platforms.The Ontario Genomics Institute OGI also helps scientists find paths to the marketplace for their discoveries and the products to which they lead, and it works through diverse outreach and educational activities to raise awareness and facilitate informed public dialogue about genomics and its social impacts.Extracellular: In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid.PSI Protein Classifier: PSI Protein Classifier is a program generalizing the results of both successive and independent iterations of the PSI-BLAST program. PSI Protein Classifier determines belonging of the found by PSI-BLAST proteins to the known families.Global microbial identifier: The genomic epidemiological database for global identification of microorganisms or global microbial identifier (GMI) is a platform for storing whole genome sequencing (WGS) data of microorganisms, for the identification of relevant genes and for the comparison of genomes to detect and track-and-trace infectious disease outbreaks and emerging pathogens. The database holds two types of information: 1) genomic information of microorganisms, linked to, 2) metadata of those microorganism such as epidemiological details.List of sequenced eukaryotic genomesDNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Molecular evolution: Molecular evolution is a change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes.Mac OS X Server 1.0Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?Internet organizations: This is a list of Internet organizations, or organizations that play or played a key role in the evolution of the Internet by developing recommendations, standards, and technology; deploying infrastructure and services; and addressing other major issues.Sequence clustering: In bioinformatics, sequence clustering algorithms attempt to group biological sequences that are somehow related. The sequences can be either of genomic, "transcriptomic" (ESTs) or protein origin.Immersive technologyCellular microarray: A cellular microarray is a laboratory tool that allows for the multiplex interrogation of living cells on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots.Chromosome regionsProteomics Standards Initiative: The Proteomics Standards Initiative (PSI) is a working group of Human Proteome Organization. It aims to define data standards for proteomics in order to facilitate data comparison, exchange and verification.Coles PhillipsCS-BLASTClonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.Microbiota: A microbiota is "the ecological community of commensal, symbiotic and pathogenic microorganisms that literally share our body space". Joshua Lederberg coined the term, emphasising the importance of microorganisms inhabiting the human body in health and disease.Genetic variation: right|thumbConference and Labs of the Evaluation Forum: The Conference and Labs of the Evaluation Forum (formerly Cross-Language Evaluation Forum), or CLEF, is an organization promoting research in multilingual information access (currently focusing on European languages). Its specific functions are to maintain an underlying framework for testing information retrieval systems and to create repositories of data for researchers to use in developing comparable standards.SciDBMassive parallel sequencing: Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged in 1994-1998 and became commercially available since 2005.Return of results: Return of results is a concept in research ethics which describes the extent of the duty of a researcher to reveal and explain the results of research to a research participant.ParaHox: The ParaHox gene cluster is an array of homeobox genes (involved in morphogenesis, the regulation of patterns of anatomical development) from the Gsx, Xlox (Pdx) and Cdx gene families.Human Proteinpedia: Human Proteinpedia is a portal for sharing and integration of human proteomic data,.Kandasamy et al.David Rimoin: David Lawrence Rimoin (November 9, 1936 – May 27, 2012) was a Canadian American geneticist. He was especially noted for his research into the genetics of skeletal dysplasia (dwarfism), inheritable diseases such as Tay–Sachs disease, and diabetes.Pharmacogenetics: Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.List of molecular graphics systems: This is a list of software systems that are used for visualizing macromolecules.Library (biology): In molecular biology, a library is a collection of DNA fragments that is stored and propagated in a population of micro-organisms through the process of molecular cloning. There are different types of DNA libraries, including cDNA libraries (formed from reverse-transcribed RNA), genomic libraries (formed from genomic DNA) and randomized mutant libraries (formed by de novo gene synthesis where alternative nucleotides or codons are incorporated).Walter Reed Army Institute of ResearchLattice protein: Lattice proteins are highly simplified computer models of proteins which are used to investigate protein folding.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.Plant Proteome Database: The Plant Proteome Database is a National Science Foundation-funded project to determine the biological function of each protein in plants.Sun Q, Zybailov B, Majeran W, Friso G, Olinares PD, van Wijk KJ.WGAViewer: WGAViewer is a bioinformatics software tool which is designed to visualize, annotate, and help interpret the results generated from a genome wide association study (GWAS). Alongside the P values of association, WGAViewer allows a researcher to visualize and consider other supporting evidence, such as the genomic context of the SNP, linkage disequilibrium (LD) with ungenotyped SNPs, gene expression database, and the evidence from other GWAS projects, when determining the potential importance of an individual SNP.Biological network: A biological network is any network that applies to biological systems. A network is any system with sub-units that are linked into a whole, such as species units linked into a whole food web.List of systems biology conferences: Systems biology is a biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences.De novo transcriptome assembly: De novo transcriptome assembly is the method of creating a transcriptome without the aid of a reference genome.Gene duplication: Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene.Weedy rice: Weedy rice, also known as red rice, is a variety of rice (Oryza) that produces far fewer grains per plant than cultivated rice and is therefore considered a pest. The name "weedy rice" is used for all types and variations of rice which show some characteristic features of cultivated rice and grow as weeds in commercial rice fields.PlasmoDB: PlasmoDB is a biological database for the genus Plasmodium. The database is a member of the EuPathDB project.Flux (metabolism): Flux, or metabolic flux is the rate of turnover of molecules through a metabolic pathway. Flux is regulated by the enzymes involved in a pathway.Indian Journal of Medical Microbiology: The Indian Journal of Medical Microbiology is a peer-reviewed open-access medical journal published by Medknow Publications on behalf of the Indian Association of Medical Microbiology. The journal publishes articles on medical microbiology including bacteriology, virology, phycology, mycology, parasitology, and protozoology.Protein subcellular localization prediction: Protein subcellular localization prediction (or just protein localization prediction) involves the computational prediction of where a protein resides in a cell.Horizontal gene transfer in evolutionProtein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Genetic predisposition: A genetic predisposition is a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or population under the influence of environmental conditions. In medicine, genetic susceptibility to a disease refers to a genetic predisposition to a health problem,What does it mean to have a genetic predisposition to a disease?Population stratification: Population stratification is the presence of a systematic difference in allele frequencies between subpopulations in a population possibly due to different ancestry, especially in the context of association studies. Population stratification is also referred to as population structure, in this context.Plant breeders' rights: Plant breeders' rights (PBR), also known as plant variety rights (PVR), are rights granted to the breeder of a new variety of plant that give the breeder exclusive control over the propagating material (including seed, cuttings, divisions, tissue culture) and harvested material (cut flowers, fruit, foliage) of a new variety for a number of years.Nutrigenetics: Nutrigenetics is a branch of nutritional genomics which aims to identify genetic susceptibility to diseases and genetic variation in the effects of nutrient intake on the genome. Nutrigenetics is not to be confused with nutrigenomics, which focuses on the role specific foods have in activating genes that affect susceptibility to certain illnesses such as Alzheimer’s Disease and cancer.Biotechnology Industry Organization: The Biotechnology Industry Organization (BIO) is the largest trade organization to serve and represent the biotechnology industry in the United States and around the world.Anna Edney, "Biosciences Defy U.Ferric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.National Human Genome Research Institute: 240px|right The National Human Genome Research Institute (NHGRI) is a division of the National Institutes of Health, located in Bethesda, Maryland.MIPModDB: MIPModDB is a database of comparative protein structure models of MIP (Major intrinsic proteins) family of proteins.Sweet sorghumExogenous bacteria: Exogenous bacteria are microorganisms introduced to closed biological systems from the external world. They exist in aquatic and terrestrial environments, as well as the atmosphere.Andrew Dickson WhiteAcheiropodiaProcess mining: Process mining is a process management technique that allows for the analysis of business processes based on event logs. The basic idea is to extract knowledge from event logs recorded by an information system.Metabolomics: Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles.Open reading frame: In molecular genetics, an open reading frame (ORF) is the part of a reading frame that has the potential to code for a protein or peptide. An ORF is a continuous stretch of codons that do not contain a stop codon (usually UAA, UAG or UGA).Dda (DNA-dependent ATPase): Dda (short for DNA-dependent ATPase; also known as Dda helicase and Dda DNA helicase) is the 439-amino acid 49,897-atomic mass unit protein coded by the Dda gene of the bacteriophage T4 phage, a virus that infects enterobacteria.GAI (Arabidopsis thaliana gene)

(1/10766) Analysis of flanking sequences from dissociation insertion lines: a database for reverse genetics in Arabidopsis.

We have generated Dissociation (Ds) element insertions throughout the Arabidopsis genome as a means of random mutagenesis. Here, we present the molecular analysis of genomic sequences that flank the Ds insertions of 931 independent transposant lines. Flanking sequences from 511 lines proved to be identical or homologous to DNA or protein sequences in public databases, and disruptions within known or putative genes were indicated for 354 lines. Because a significant portion (45%) of the insertions occurred within sequences defined by GenBank BAC and P1 clones, we were able to assess the distribution of Ds insertions throughout the genome. We discovered a significant preference for Ds transposition to the regions adjacent to nucleolus organizer regions on chromosomes 2 and 4. Otherwise, the mapped insertions appeared to be evenly dispersed throughout the genome. For any given gene, insertions preferentially occurred at the 5' end, although disruption was clearly possible at any intragenic position. The insertion sites of >500 lines that could be characterized by reference to public databases are presented in a tabular format at http://www.plantcell. org/cgi/content/full/11/12/2263/DC1. This database should be of value to researchers using reverse genetics approaches to determine gene function.  (+info)

(2/10766) Microbial genomics: from sequence to function.

The era of genomics (the study of genes and their function) began a scant dozen years ago with a suggestion by James Watson that the complete DNA sequence of the human genome be determined. Since that time, the human genome project has attracted a great deal of attention in the scientific world and the general media; the scope of the sequencing effort, and the extraordinary value that it will provide, has served to mask the enormous progress in sequencing other genomes. Microbial genome sequencing, of particular interest to the community studying emerging infectious diseases, prompted the series of articles presented in the following pages. These articles review technological and scientific advances that have occurred since publication of the Haemophilus influenzae genome sequence in July 1995; that was the first demonstration that an entire genome sequence could be deciphered by a "shotgun" approach, i.e., the sequencing and assembly of random fragments of the genome. This is now the method of choice for sequencing of most other genomes, including human (as performed by Celera Genomics).  (+info)

(3/10766) Genomics and bacterial pathogenesis.

Whole-genome sequencing is transforming the study of pathogenic bacteria. Searches for single virulence genes can now be performed on a genomewide scale by a variety of computer and genetic techniques. These techniques are discussed to provide a perspective on the developing field of genomics.  (+info)

(4/10766) Comparative genomics and understanding of microbial biology.

The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.  (+info)

(5/10766) Using DNA microarrays to study host-microbe interactions.

Complete genomic sequences of microbial pathogens and hosts offer sophisticated new strategies for studying host-pathogen interactions. DNA microarrays exploit primary sequence data to measure transcript levels and detect sequence polymorphisms, for every gene, simultaneously. The design and construction of a DNA microarray for any given microbial genome are straightforward. By monitoring microbial gene expression, one can predict the functions of uncharacterized genes, probe the physiologic adaptations made under various environmental conditions, identify virulence-associated genes, and test the effects of drugs. Similarly, by using host gene microarrays, one can explore host response at the level of gene expression and provide a molecular description of the events that follow infection. Host profiling might also identify gene expression signatures unique for each pathogen, thus providing a novel tool for diagnosis, prognosis, and clinical management of infectious disease.  (+info)

(6/10766) Automatic detection of conserved gene clusters in multiple genomes by graph comparison and P-quasi grouping.

We previously reported two graph algorithms for analysis of genomic information: a graph comparison algorithm to detect locally similar regions called correlated clusters and an algorithm to find a graph feature called P-quasi complete linkage. Based on these algorithms we have developed an automatic procedure to detect conserved gene clusters and align orthologous gene orders in multiple genomes. In the first step, the graph comparison is applied to pairwise genome comparisons, where the genome is considered as a one-dimensionally connected graph with genes as its nodes, and correlated clusters of genes that share sequence similarities are identified. In the next step, the P-quasi complete linkage analysis is applied to grouping of related clusters and conserved gene clusters in multiple genomes are identified. In the last step, orthologous relations of genes are established among each conserved cluster. We analyzed 17 completely sequenced microbial genomes and obtained 2313 clusters when the completeness parameter P: was 40%. About one quarter contained at least two genes that appeared in the metabolic and regulatory pathways in the KEGG database. This collection of conserved gene clusters is used to refine and augment ortholog group tables in KEGG and also to define ortholog identifiers as an extension of EC numbers.  (+info)

(7/10766) The gene guessing game.

A recent flurry of publications and media attention has revived interest in the question of how many genes exist in the human genome. Here, I review the estimates and use genomic sequence data from human chromosomes 21 and 22 to establish my own prediction.  (+info)

(8/10766) Featured organism: Danio rerio, the zebrafish.

The zebrafish has long been a favourite model for the study of vertebrate development. Here we provide an overview of the current state of knowledge and resources for the study of this fish, with comments on the future direction of zebrafish genomics from Professor Mark Fishman and Dr Stephen Wilson.  (+info)



Office of Public Health G


  • The CDC Office of Public Health Genomics provides timely and credible information for the effective and responsible translation of genomics research into population health benefits. (cdc.gov)
  • The Office of Public Health Genomics tracks epidemiologic study results in our weekly horizon scan and Advanced Molecular Detection Clips and deposits relevant publications in the Public Health Genomics Knowledge Base . (cdc.gov)

Complete Genomics


  • And this summer, Complete Genomics, a biotech firm in Mountain View, California, plans to announce that it will sequence an individual genome for $5,000. (newsweek.com)
  • When little known start-up Complete Genomics announced last fall that it planned to offer a human genome sequencing service for $5000 a pop, the sequencing community responded with a mixture of excitement and skepticism. (technologyreview.com)
  • Like other new sequencing technologies, Complete Genomics' process reads the sequence of very short pieces of DNA, which then must be computationally synthesized to create a whole genome. (technologyreview.com)
  • Complete Genomics' CEO Cliff Reid presented the research at a conference in Florida last night. (technologyreview.com)
  • Complete Genomics' technology is centered on two innovations: a way to densely pack DNA, developed by Rade Drmanac, the company's chief scientific officer, and a method to randomly read DNA letters, based on sequencing technology developed at George Church's lab at Harvard . (technologyreview.com)
  • In preparation for its service launch, Complete Genomics is rapidly scaling up its commercial genome center. (technologyreview.com)

Pathogen Genomics


  • Links to epidemiology articles relevant to pathogen genomics. (cdc.gov)
  • CDC curated database that features epidemiologic studies of human and pathogen genomics. (cdc.gov)

Synthetic Genomics


  • A former Synthetic Genomics attorney alleges that the firm discriminated against her and other female employees, according to the San Diego Union-Tribune . (genomeweb.com)

pharmaceutical


  • From academic research labs to pharmaceutical drug development, Axygen genomics products are right at home in virtually every area of genomics research - in the U.S. and around the world. (corning.com)

research


  • To effectively organize and build upon these remarkable gains in genomics research, the Museum established, in spring 2001, the Sackler Institute for Comparative Genomics (SICG). (amnh.org)
  • These, together with research collaborations with other prominent scientific institutions, position the Museum to enhance its important contributions to genomics research. (amnh.org)
  • With the publication of the Animal Genomics Blueprint by USDA, and the development of a strategic research agenda for Farm Animal Breeding and Reproduction in the EU, this workshop comes at an important time for farm animal genomics. (europa.eu)

Overview


science


  • No matter how diverse your requirements, stay focused on the complex science of genomics, while we take care of those little details that can make a huge difference. (corning.com)

offer


  • Select distributors offer Axygen Genomics products. (corning.com)

people


  • When a deadly foodborne strain of Escherichia coli recently killed dozens of people in Europe, researchers at BGI (formerly Beijing Genomics Institute) teamed up with collaborators at the University Medical Centre Hamburg-Eppendorf to sequence the microbe's genome. (genengnews.com)